JP4784294B2 - Sensor device and sensor chip measurement system - Google Patents

Description

  The present invention relates to a sensor device used for quantitative determination of a specific component in a trace sample, and more particularly to a biosensor device. The present invention also relates to a sensor chip measurement system using this sensor device.

  A biosensor device is a measuring machine having a function of detachably holding a biosensor chip and obtaining a measurement result based on information from the biosensor chip. In the measurement using this biosensor device, a sample is introduced into a reaction part in the chip, a biochemical reaction such as an enzyme reaction or an antigen-antibody reaction is caused in the reaction part, and information obtained by this chemical reaction is obtained from the biosensor device. Is output.

  A biosensor chip uses an excellent molecular identification function of a living body, and has attracted attention as a device that enables quick and simple measurement of a small amount of chemical substances. For example, the amount of glucose in blood (blood glucose Value) and blood glucose level sensor for measuring urine sugar level, etc., it is used for home health diagnosis (self-care) for self-management and prevention of diabetes and is commercially available.

  Conventionally, in a commercially available biosensor device, it is necessary to insert the sensor chip into the connector in the correct orientation. Therefore, many commercially available biosensor devices and biosensor chips are provided with a structure for preventing insertion in the wrong direction.

  For example, in Japanese Patent Laid-Open No. 4-357449 (Patent Document 1), if a sensor chip is provided with an asymmetric protrusion and the insertion direction is not correct, the chip electrode cannot be physically connected to the connector. In addition, a biosensor measurement apparatus (biosensor device) having a structure in which the drive power supply of the apparatus is not turned on is disclosed.

  However, in such a sensor device, it is impossible to prevent the mistake itself to be inserted in the wrong direction. When the sensor device is inserted in the wrong direction, an operation of reinserting the chip is required. Also, if the chip is inserted in the wrong direction and the user does not check the display on the measuring machine, there is a possibility that blood sampling will be started as it is. After that, you will notice the insertion error for the first time, which is a loss of time and chips.

  In Japanese Patent Laid-Open No. 11-83787 (Patent Document 2), an oxidoreductase-immobilized biosensor (biosensor chip) in which a working electrode and a counter electrode are arranged so as to have a facing structure and each electrode thereof are inserted. Or a biosensor device having a connector inserted between the electrodes (Claims 1 and 3).

  In this biosensor device, each electrode is arranged so as to have a face-to-face structure, so conduction is possible regardless of the insertion direction of the chip, and even if the insertion direction is incorrect, measurement is performed without reinserting the chip. Is possible. However, in this biosensor device, only a chip having a facing structure of the working electrode and the counter electrode, that is, a chip having a special structure called a counter electrode can be used, and a chip having a general single-sided electrode structure cannot be used.

  Japanese Patent Application Laid-Open No. 11-248667 (Patent Document 3) describes the width of the substrate so that the end portions of the two substrates provided on the inside so that the working electrode and the counter electrode have a facing structure are staggered. A biosensor device is described in which a biosensor chip cut into half or less and a connector having a leaf spring-like terminal portion connectable to each exposed electrode lead portion is provided (Claim 1).

Even with this biosensor device, conduction is possible regardless of the insertion direction of the chip, but only a chip having a counter electrode on the inner side and having an end with a special structure as described above can be used. A single-sided electrode structure chip cannot be used. In addition, the chip having such a special structure is difficult to manufacture as compared with a chip having a general single-sided electrode structure, and the cost is increased.
JP-A-4-357449 Japanese Patent Laid-Open No. 11-83787 (Claims 1 and 3) JP-A-11-248667 (Claim 1)

  The present invention has been made to solve the above-described problems of the prior art, and even when a sensor chip having a general single-sided electrode structure is used, it is electrically connected to the electrode of the sensor chip regardless of the direction of insertion. It is an object to provide a sensor device that can perform the same measurement (Problem 1).

  Another object of the present invention is to provide a sensor device that can be changed to measurement under different conditions only by changing the direction of insertion of the sensor chip (Problem 2).

  It is another object of the present invention to provide a sensor device that can perform measurement under conditions corresponding to each of two types of sensor chips by simply inserting the sensor chip into the connector. 3).

  Another object of the present invention is to provide a sensor chip measurement system that facilitates management of measurements using this sensor device (Problem 4).

  The above-described problem has a connector that is electrically connected to an electrode of a sensor chip having at least a pair of electrodes on one side, and the connector is a pair of elastically deformable conductive terminals that are arranged to face each other in a non-contact state. This is solved by a sensor device (claim 1) characterized in that the sensor chip is gripped and fixed by the conduction terminal and is conducted regardless of the orientation of the sensor chip.

  The connector of the sensor device has a recess into which the sensor chip is inserted. The sensor device of the present invention means an upper surface and a lower surface of the recess (one and the other of the surfaces parallel to the inserted sensor chip surface). ) Have elastically deformable conductive terminals so as to face each other, and have two or more pairs of the conductive terminals. That is, since there are two or more conducting terminals on both the upper surface and the lower surface, the sensor chip can be inserted in any direction if each is arranged so as to correspond to a plurality of electrodes such as a counter electrode and a working electrode of the sensor chip. Even if it does, the conduction | electrical_connection terminal corresponding to each electrode exists and it will conduct | electrically_connect. Therefore, if the upper and lower conductive terminals are configured to be equivalent in terms of circuit, even if they are inserted face down, they will conduct as if they were inserted face up and perform the same measurement. (I.e., Problem 1 is achieved).

  In the sensor device of the present invention, it is preferable that the sensor chip inserted between the opposing conductive terminals is held and fixed only by the conductive terminals. In this case, the conduction terminal is elastically deformed by the insertion of the sensor chip, but the sensor chip is gripped and fixed only by the pressure due to the elastic deformation of the conduction terminals on both sides. As a result, the same contact pressure is applied to the contacts on both sides, so that one contact does not cause poor contact compared to the other contact.

  The fact that the conductive terminals are arranged to face each other means that the horizontal positions of the two conductive terminals facing each other (positions in the direction of the inserted sensor chip surface) are close to each other. It is preferable that the horizontal position is closer, and it is particularly preferable that the opposing conductive terminals are arranged so as to be aligned in a direction perpendicular to the sensor chip surface to be inserted.

  That is, in the sensor device, since various measurements are performed in a state where the chip is connected to the connector, the sensor chip needs to be firmly held and fixed. For this reason, the elastic force of the conduction terminal needs to be increased to some extent. On the other hand, some sensor chips are made of a soft material such as a relatively thin resin plate. Therefore, when the horizontal positions of the conductive terminals are separated from each other, the sensor chip is deformed to be warped. there is a possibility. By arranging the opposing conductive terminals so as to be aligned in a direction perpendicular to the surface of the sensor chip to be inserted, the occurrence of warpage can be prevented. Claim 2 corresponds to this preferable mode.

  If the number of conducting terminals provided on each of the upper and lower surfaces of the concave portion of the connector is equal to the number of electrodes (2 in the case of only two electrodes, the counter electrode and the working electrode), the current necessary for measurement is conducted. Can be measured. However, it is preferable to increase the number of conductive terminals in contact with each electrode to more than two, because gripping and fixing become stronger and the posture of the chip is stabilized, and the possibility of poor conduction is reduced.

  The elastically deformable conductive terminal can be formed from an electrically conductive material such as copper, silver, gold, or platinum. In particular, phosphor bronze is a preferable material from the viewpoint of elastic deformation and conductivity. In order to increase the durability of the contact portion with the chip, a coating such as gold or chrome may be applied. In addition, the conductive terminals facing each other as described later (FIG. 5) can be manufactured by punching a single metal plate. Therefore, the connector can be manufactured with high productivity. In addition, since the connector which has such a conduction terminal is marketed as a connector for FPC which is an electronic circuit component, it is also possible to utilize it.

  As described above, the conductive terminals on the upper surface and the lower surface need to be configured to be equivalent in terms of circuit in order to conduct the same and perform the same measurement even if the insertion direction of the sensor chip is different. There is. Taking a biosensor device using an electrode reaction as an example, a conduction terminal that contacts the working electrode / counter electrode when inserted in one direction (hereinafter referred to as the front direction), and the other direction (hereinafter referred to as the back direction) The conductive terminal that contacts the working electrode / counter electrode when inserted in step 2) is equivalent to the circuit, and even if the front and back of the biosensor chip are reversed, the working electrode and the counter electrode are not switched. It is necessary to keep it.

  A third aspect of the present invention corresponds to this aspect, wherein the sensor device includes a circuit to which a conductive terminal that contacts each electrode of the sensor chip is connected when the sensor chip is inserted face-up, and the sensor chip is backside. It is an object of the present invention to provide a sensor device characterized in that a circuit to which a conductive terminal that comes into contact with each electrode of the sensor chip is connected when inserted in a direction is equivalent. Note that the front and back directions do not mean a specific direction, but when one of the surfaces of the sensor chip 2 faces the upper surface of the connector recess, when facing up, it faces the lower surface Means to face down.

  As described above, in order to conduct the same and perform the same measurement even if the direction of insertion of the sensor chip is different, the conductive terminals on the upper and lower surfaces of the concave portion of the connector should be equivalent in circuit. On the other hand, a sensor device that can perform different measurements by changing the direction of insertion of the sensor chip by making the circuit to which the conductive terminals on the upper and lower surfaces connect non-equivalent. (Problem 2 is achieved).

  Claim 4 corresponds to this sensor device, and is the sensor device according to claim 1 or 2, wherein the sensor chip is in contact with each electrode of the sensor chip when the sensor chip is inserted face up. Provided is a sensor device characterized in that a circuit to which a conducting terminal is connected and a circuit to which a conducting terminal that contacts each electrode of the sensor chip is connected when the sensor chip is inserted face down are not equivalent This is a developmental form of the invention described above.

  By connecting to a non-equivalent circuit, measurement conditions such as applied voltage and measurement time can be changed depending on the insertion direction of the chip. For example, depending on the user's intention, there may be a case where the user wants to know the result in a short time even if there is a large amount of measurement error, and a case where a more accurate measurement value is desired even if the time is long. In the sensor device according to the fourth aspect, for example, it is possible to set the measurement mode in a short time when it is inserted face-up, and the measurement mode with high accuracy when it is inserted face-down. Therefore, the measurement mode can be switched and the measurement can be performed simply by changing the insertion direction by the user without attaching a switching button or the like, which is very convenient.

  The sensor device according to the fourth aspect can be effectively used when measuring two types of sensor chips having different functions with the same sensor device. In the case of sensor chips having different functions, the measurement conditions such as applied voltage and measurement time are usually different, but a conductive terminal corresponding to one sensor chip is provided on the upper surface of the concave portion of the connector, and the other sensor chip If a corresponding conduction terminal is provided on the lower surface, one sensor chip is inserted face up, and the other sensor chip is inserted face down, so that there is a difference corresponding to each sensor chip without attaching a switching button or the like. The measurement conditions can be switched.

  In this case, it is preferable to include means for preventing malfunction when each sensor chip is inserted in a direction opposite to a predetermined direction. As a sensor device having a malfunction prevention means, for example, one type of sensor among the two types of sensor chips in which the conductive terminal on one side of the opposing conductive terminal is different in electrode arrangement position and / or electrode shape is used. A sensor device is characterized in that it makes measurable contact with only the electrode of the chip, and the conducting terminal on the other side makes measurable contact with only the electrode of the other sensor chip. Claim 5 corresponds to this aspect.

  Here, when the conducting terminal on one side makes measurable contact, all the electrodes necessary for measurement come into contact with at least a part of the conducting terminal on one side and become measurable. Meaning. The measurable contact is limited to the case where the sensor chip is inserted in the correct direction. When the sensor chip is inserted in the reverse direction, the measurable contact is not performed. To do this, when the sensor chip is inserted in the reverse direction, some of the electrodes required for measurement do not come into contact with the conduction terminal, or the chip detection function does not operate and the power is not turned on. There is a method of making the structure.

  As the sensor device of the present invention, in addition to the sensor device described above, a device having a set of conductive terminals that make measurable contact for each of a plurality of types of sensor chips having different electrode placement positions and / or electrode shapes. Can be mentioned. In this case, if the circuits connected to each of the plurality of sets of conductive terminals are not equivalent to each other, measurement corresponding to each of a number of different types of sensor chips can be performed. The sixth aspect provides a sensor device corresponding to this aspect.

  As a simple example of such a sensor device, there are three conductive terminals a, b and c on the upper surface of the concave portion of the connector, and three conductive terminals a ′, b ′ and c ′ on the lower surface. When the sensor chip A is inserted face up, a and b make measurable contact, and when the sensor chip B is inserted face up, a and c make measurable contact. . By making the circuit connecting a and b and the circuit connecting a and c non-equivalent to each other, measurement corresponding to each of the sensor chip A and the sensor chip B can be performed.

  Further, when the sensor chip A is inserted face down, a ′ and b ′ make measurable contact, and when the sensor chip B is inserted face down, a ′ and c ′ can be measured. By making contact and making all circuits connected to each other non-equivalent, four types of measurements can be performed using two types of sensor chips.

  On the other hand, if the circuit connecting a and b is equivalent to the circuit connecting a 'and b', the same measurement can be performed regardless of the insertion direction of the sensor chip A. The same applies to the sensor chip B.

  Some of the above sensor devices can perform the same measurement regardless of the insertion direction of the sensor chip. However, even in this case, the sensor device has a function of detecting and displaying the direction when the sensor chip is inserted. This is convenient for the user. For example, the overall structure of the sensor chip including the sample introduction port is often not symmetrical on the front and back sides, and there are many chips where the sample introduction port exists only on one side surface. Since the position of the inlet is reversed, the direction of contact between the sample and the sensor chip differs depending on the direction of the inlet, so that information on the direction of insertion is useful to the user.

  As a sensor device having a function of detecting and displaying a direction when a sensor chip is inserted, a plurality of conduction terminals that can simultaneously contact one electrode of the sensor chip when the sensor chip is inserted, and between the plurality of conduction terminals A sensor device having a means for confirming the continuity of is included. The seventh aspect provides a sensor device corresponding to this aspect.

  When the sensor chip is inserted, the sensor device has two or more conduction terminals that may simultaneously contact one electrode of the sensor chip and two or more means for confirming conduction between the plurality of conduction terminals. May be. For example, in the sensor device according to claim 5 or 6, the means for checking is provided for each of the different types of sensor chips and for each of the insertion directions, so that the type of sensor chip and the direction of insertion are provided. Can be accurately discriminated, and an operation (measurement) corresponding to each can be performed.

  In addition, as a sensor chip used for the sensor device of this invention, the same thing as the conventional sensor chip, especially the sensor chip of a single-sided electrode structure can be used. As for the sensor device, the same sensor device as that of the conventional sensor device can be used except that the connector and the circuit connected thereto have the above-described characteristics.

  The sensor device of the present invention described above is preferably used as a biosensor device using a biosensor chip, for example, in a blood glucose level sensor for measuring glucose level (blood glucose level) or urine sugar level in blood. Can do. Claim 8 corresponds to this preferred embodiment, and provides the sensor device, which is the biosensor device.

  When the sensor device of the present invention has three or more conduction terminals, some of the terminals are not connected to the circuit, so that they are compatible with the terminals connected to the circuit (connecting to be conductive). Only the sensor chip can be measured, and other sensor chips that are not compatible with this terminal can be disabled. In addition, the terminal connected to the circuit can be changed only by changing the wiring in the sensor device, and therefore the type of sensor chip that can be measured can be changed.

  For example, in order to improve safety, legal compliance, sales management, etc., only specific sensor chips can be used in specific areas, and other sensor chips may not be measurable. Since the wiring in the device can be easily changed, this management can be easily performed by the above-described method, and the above problem 4 can be achieved.

  That is, the present invention has three or more elastically deformable conductive terminal pairs arranged to face each other in a non-contact state, a connector for gripping and fixing a sensor chip by the conductive terminals, and some conductive terminals Multiple types of wiring that makes the other conductive terminals non-measurable mode, multiple types of sensor chips that have at least a pair of electrodes on one side and can be measured only with a part of the conductive terminals A sensor device having one type of wiring selected from among the plurality of types of the connector and the wiring is mounted with one type of sensor chip selected from the plurality of types of the sensor chip. The present invention provides a sensor chip measuring system (claim 9).

  The sensor device used here is included in the sensor device according to the first to eighth aspects of the present invention, further including three or more pairs of conduction terminals, and wiring having only a part of the conduction terminals in a measurable mode. It is characterized by. Note that the measurable mode refers to being electrically connected to a circuit so that measurement can be performed by attaching a suitable sensor chip, and the non-measurable mode is electrically connected to the circuit. Say nothing.

  The sensor device of the present invention, wherein when the sensor chip is inserted face up, a circuit to which a conductive terminal that contacts each electrode of the sensor chip is connected, and when the sensor chip is inserted face down, the sensor chip By using an equivalent circuit to which the conductive terminals in contact with each of the electrodes are connected, the same measurement can be made accurate regardless of which direction the sensor chip having the one-side electrode structure is inserted. Therefore, even if the chip is inserted in the wrong direction, there is no need to replace the chip.

  In addition, when the sensor chip is inserted face up and when it is inserted face down, the circuit to which the conductive terminal that contacts each electrode of the sensor chip is connected is non-equivalent. Only by changing the direction of insertion, the measurement can be changed to different conditions. In addition, it is possible to perform measurement under conditions corresponding to each of two different sensor chips by using one sensor device.

  According to the sensor chip measurement system of the present invention, it is possible to easily manage such that only a specific sensor chip can be used and other sensor chips cannot be measured.

  Next, the best mode for carrying out the present invention will be described with reference to the drawings. Note that the present invention is not limited to this form, and can be changed to other forms as long as the gist of the present invention is not impaired.

  FIG. 1 shows an example of a connector of a sensor device of the present invention. FIG. 1a is a schematic sectional view taken along a plane perpendicular to the sensor chip insertion direction, and FIG. 1b is parallel to the sensor chip insertion direction. FIG.

  The conductive terminals 2a, 2b, 2c and 2d are obtained by bending or punching an elastically deformable metal plate, and one end of each of the conductive terminals 2a, 2b, 2c and 2d is a groove of the housing 1 formed of an insulating material (for example, resin). The other end is fixed in 1a, and 2a and 2c, 2b and 2d face each other and are not in contact with each other in order to grip and fix the sensor device. The method of fixing the conductive terminals 2a, 2b, 2c, and 2d in the groove 1a is not particularly limited, but it is integrated by a method of mechanically fitting, a method of fixing with an adhesive or the like, and a method such as insert molding at the time of injection molding. Methods and the like.

  FIG. 2 shows a state in which the sensor chip 3 is inserted into the sensor device of the example of FIG. 1, and FIG. 2a shows a state perpendicular to the sensor chip insertion direction when the sensor chip 3 is inserted face up. FIG. 2B is a schematic cross-sectional view, and FIG. 2B is a schematic cross-sectional view taken along a plane parallel to the sensor chip insertion direction when the sensor chip 3 is inserted face up. FIG. FIG. 2D is a schematic cross-sectional view taken along a plane perpendicular to the sensor chip insertion direction when inserted, and FIG. 2D is a cross-section taken along a plane parallel to the sensor chip insertion direction when the sensor chip 3 is inserted face down. FIG.

  When the sensor chip 3 is inserted, the conduction terminals 2a, 2b, 2c and 2d are elastically deformed, and the sensor chip 3 is held and fixed by the elastic force. As shown in FIG. 2a, when the sensor chip 3 is inserted face up, the working electrode 4 is in contact with the conducting terminal 2a and the counter electrode 4 'is in contact with the conducting terminal 2b. On the other hand, as shown in FIG. 2c, when the sensor chip 3 is inserted backward, the working electrode 4 is in contact with the conduction terminal 2d and the counter electrode 4 'is in contact with the conduction terminal 2c. Therefore, when the circuit to which the conduction terminals 2a and 2b are connected and the circuit to which the conduction terminals 2c and 2d are connected are equivalent, even if the sensor chip 3 is inserted in different directions, the same conduction is performed and the same measurement can be performed. it can. Further, since the sensor chip 3 is held and fixed only by the elastic force of the conduction terminals 2a, 2b, 2c and 2d, the same elastic force is applied to the conduction terminals on both sides. Further, by making the shapes, materials, etc. of 2a and 2b, 2c and 2d equivalent, there is no difference in the elastic force between them, so that some of the conductive terminals do not cause poor contact. .

  Further, when the circuit connected to the conduction terminals 2a and 2b and the circuit connected to the conduction terminals 2c and 2d are not equivalent, the measurement is performed under different measurement conditions by changing the direction in which the sensor chip 3 is inserted. be able to. For example, it is possible to switch to a measurement mode in which measurement conditions such as applied voltage and measurement time are different by simply changing the insertion direction. Further, in the case of sensor chips having different functions, usually, measurement conditions such as applied voltage and measurement time are different, but two different sensor chips can be used properly by this type of sensor device. That is, one sensor chip of two types of sensor chips having different electrode arrangement positions and / or electrode shapes can be measured by a circuit connected to the conduction terminals 2a and 2b, and the other sensor chip can be measured with the conduction terminal 2c, By making measurement possible by a circuit connected to 2d, it is possible to perform measurement under different conditions by properly using the two types of sensor chips by simply inserting the sensor chip in a different orientation.

  FIG. 3 shows an example of a connector in which opposing conductive terminals are arranged so as to be aligned in a direction perpendicular to the surface of the sensor chip to be inserted, that is, an example of the connector according to the aspect of claim 2. It is the cross-sectional schematic cut | disconnected by the surface perpendicular | vertical to. As shown in FIG. 3, 2a and 2c, 2b and 2d are provided at positions aligned in a direction perpendicular to the sensor chip surface. With such an arrangement, it is possible to solve the problem that the sensor chip manufactured from a soft material such as a relatively thin resin plate is deformed to be warped by the elastic force of the conduction terminal. Except for the position of the conductive terminal, this connector is equivalent to the connector in the example of FIG.

  FIG. 4 shows an example of a connector in which the number of conductive terminals in contact with one electrode is two. 4a is a schematic cross-sectional view taken along a plane perpendicular to the sensor chip insertion direction, and FIG. 4b is a cross-sectional view taken along a plane perpendicular to the sensor chip insertion direction when the sensor chip 3 is inserted face up. FIG. As shown in FIG. 4b, the working electrode 4 of the sensor chip 3 is in contact with the conduction terminals 2a and 2a ′, the counter electrode 4 ′ is in contact with the conduction terminals 2b and 2b ′, and the sensor chip 3 Since the opposite surface is in contact with the conduction terminals 2c, 2c ′, 2d, and 2d ′, the sensor chip is more firmly gripped and fixed, and the orientation of the chip is stabilized, as well as the possibility of conduction failure. Is also a desirable form.

  Also, as shown in FIG. 4a, in this example, conduction monitors 5 and 5 ', that is, means for confirming conduction, are provided between the conduction terminals 2a and 2a' and between the conduction terminals 2c and 2c ', respectively. ing. When the sensor chip 3 is inserted face up (that is, in the case shown in FIG. 4b), the conductive terminals 2a and 2a 'are electrically connected by the working electrode 4, while the conductive terminals 2c and 2c' are not electrically connected. When the sensor chip 3 is inserted face down, the conduction terminals 2c and 2c 'are conducted by the counter electrode 4', while the conduction terminals 2a and 2a 'are not conducted. Therefore, by confirming this continuity with the continuity monitors 5, 5 ', it can be confirmed whether the chip is inserted face up or face down.

  FIG. 5 is a schematic cross-sectional view taken along a plane parallel to the insertion direction of the sensor chip, showing an example in which the opposing conductive terminals have an integral structure. The conduction terminal 2 in this example is manufactured by punching out a single elastically deformable metal plate and is fitted into the groove 1 a of the housing 1.

  FIG. 6 shows a sensor device capable of measuring by using two types of sensor chips 6 and 7 having different electrode arrangement positions and / or electrode shapes, when the sensor chip is inserted in a direction opposite to a predetermined direction. It is a figure which shows an example of the connector provided with the malfunction prevention means, and is the cross-sectional schematic cut | disconnected by the surface perpendicular | vertical to the insertion direction of a sensor chip. FIG. 6a shows a case where the sensor chip 6 is inserted face up (correct orientation), FIG. 6b shows a case where the sensor chip 7 is inserted face up (incorrect orientation), and FIG. FIG. 6D shows a case where the sensor chip 7 is inserted in the reverse direction (correct direction). In FIG. 6a, the working electrode 8 and the counter electrode 8 ′ are in contact with the conducting terminals 2a and 2b, respectively. In FIG. 6b, the working electrode 9 is in contact with the conducting terminal 2b, but the counter electrode 9 ′ is There is no contact with the conducting terminal, so no measurement is performed. The same applies to the case where the sensor chip 6 or 7 is inserted backward as shown in FIGS. 6c and 6d.

  FIG. 7 shows that the number of conducting terminals is increased and the two types of sensor chips 10 and 11 are inserted in any direction to accurately determine the type of sensor chip and the direction of insertion, and the operation corresponding to each. An example of the form which can make a measuring machine be shown. FIG. 7 is a schematic cross-sectional view taken along a plane perpendicular to the sensor chip insertion direction when the sensor chip 10 is inserted face up. In such a form, since the number of conductive terminals is large, in order to increase the productivity of the connector and to avoid complication of wiring around the connector, it is preferable to use the conductive terminal having an integral structure shown in FIG. In this example as well, five conductive terminals with an integral structure are used, and each is connected to terminals A, B, C, D and E.

  FIG. 8 is a schematic cross-sectional view of the two types of sensor chips 10 and 11 taken along a plane perpendicular to the insertion direction. As shown in the figure, the shapes and positions of the electrodes (working electrode 12 and counter electrode 12 ′, working electrode 13 and counter electrode 13 ′) are different between the sensor chips 10 and 11.

  FIG. 9 schematically shows the positional relationship between the sensor chip electrodes and the respective conduction terminals of the sensor device (indicated by the names of terminals to be connected) when the six types of sensor chips are inserted into the sensor device of FIG. FIG. The thick line in FIG. 9 corresponds to the position of each electrode. For each of the six types of sensor chips, there are shown a case where it is inserted face up and a case where it is inserted face down.

  Specifically, a in FIG. 9 represents the positional relationship between each electrode position and each terminal when the sensor chip 10 is inserted face up, and e is the sensor chip 11 inserted face up. Represents the positional relationship between each electrode position and each terminal when the sensor chip 11 is inserted, h represents the positional relationship between each electrode position and each terminal when the sensor chip 11 is inserted face down, l is The positional relationship between the position of each electrode and each terminal when the sensor chip 10 is inserted face down is shown.

  FIG. 9 is a sensor chip that can be inserted into the connector of the sensor device of FIG. 7 in the same manner as the sensor chips 10 and 11, and has an electrode at a position different from the sensor chips 10 and 11, The positional relationship between each electrode and each conduction terminal of the sensor chip (b), sensor chip (c), sensor chip (d) is also schematically shown. Specifically, each figure in FIG. 9 corresponds to each sensor chip as shown below.

b: When the sensor chip (A) is inserted face up.
c: When the sensor chip (b) is inserted face up.
d: When the sensor chip (C) is inserted face up.
f: When the sensor chip (d) is inserted face up.
g: When the sensor chip (d) is inserted face down.
i: When the sensor chip (C) is inserted face down.
j: When the sensor chip (b) is inserted face down.
k: When the sensor chip (A) is inserted face down.

  As is clear from FIG. 9, when the sensor chip 10 is inserted face up, the working electrode 12 contacts the terminals A and B, the terminals A and B are electrically connected, and the counter electrode 12 ′ contacts the terminal C. To do. On the other hand, when the sensor chip 11 is inserted face up, the working electrode 13 contacts the terminals B and C, the terminals B and C are electrically connected, and the counter electrode 13 ′ contacts the terminal D.

  Further, when the sensor chip 10 is inserted face down, the working electrode 12 contacts the terminals D and E, the terminals D and E are electrically connected, and the counter electrode 12 ′ contacts the terminal C. When 11 is inserted face down, the working electrode 13 contacts the terminals C and D, the terminals C and D are electrically connected, and the counter electrode 13 ′ contacts the terminal B.

  Therefore, when the sensor device has means (not shown) for confirming conduction between the terminals, it is confirmed which of the sensor chips 10 and 11 is inserted by confirming which terminal is conducted. Also, it can be confirmed in which direction it is inserted. Similarly, for other sensor chips, it is possible to determine the type and insertion direction of the sensor chip.

  FIG. 9 shows 12 types of terminal combinations. If each of these 12 types of combinations is designed to be connected to a non-equivalent circuit, 12 types of measurements can be performed. .

  On the other hand, if the circuit in the symmetrical conduction pattern (for example, a and l, b and k) is designed to be equivalent, the same measurement can be performed regardless of the insertion direction of the sensor chip. In this case, six types of measurement using different sensor chips are possible.

  Even in the case of the connector having the structure shown in FIG. 4, even when the conductive terminals facing each other are not integrated, it is possible to determine the chip type and the insertion direction by monitoring all the conductive terminals. However, in that case, it is necessary to connect eight lead wires to both surfaces of one small connector, and wiring becomes complicated. With the configuration as shown in FIG. 7, the number of lead wires connected to the connector is five and only one side of the connector is wired, so the wiring work is extremely simple. For example, the contact of this connector can be directly connected by soldering or the like on a substrate on which five electrical contacts are exposed, without using lead wires, so that extremely high productivity can be achieved.

  Furthermore, in the sensor device in the example of FIG. 7, by not connecting some terminals to the circuit, only some sensor chips can be measured, and other sensor chips may not be measurable. it can. For example, if the terminals D and E are not connected to the circuit, as shown in FIG. 9, in the case of a and d, that is, the sensor chip 10 (front side) and the sensor chip (c) (front side) ) Only can be measured, and cannot be measured with other sensor chips.

  Therefore, according to this sensor device, the type of usable sensor chip can be easily changed by simply changing the wiring and changing the terminal connected to the circuit, and other sensor chips can be disabled. . In other words, with the sensor chip measurement system of the present invention that uses sensor devices and sensor chips in this way, only specific sensor chips can be used in specific regions for safety improvement, legal compliance, sales management, etc. Yes, it is possible to easily manage other sensor chips so that they cannot be measured.

  The wiring of the sensor device can be easily changed. In addition, in the case of the above-mentioned purpose, since the various types of sensor chips used are different only in the position of the electrodes and are equivalent in other configurations, only by changing the printing position of the electrodes in the manufacturing process. Many types of sensor chips can be easily manufactured. Therefore, even when many types of combinations of sensor devices and sensor chips that are compatible (measurable with each other) are manufactured, the productivity is not impaired.

It is a section schematic diagram showing an example of a connector of a sensor device of the present invention. It is the cross-sectional schematic which shows the other example of the connector of the sensor device of this invention. It is the cross-sectional schematic which shows the other example of the connector of the sensor device of this invention. It is the cross-sectional schematic which shows the other example of the connector of the sensor device of this invention. It is the cross-sectional schematic which shows the other example of the connector of the sensor device of this invention. It is the cross-sectional schematic which shows the other example of the connector of the sensor device of this invention. It is the cross-sectional schematic which shows the other example of the connector of the sensor device of this invention. It is a section schematic diagram showing an example of a sensor chip used for a sensor device of the present invention. It is explanatory drawing which represented typically the positional relationship of each electrode of a sensor chip, and each terminal of a sensor device.

Explanation of symbols

1 Housing 2, 2a, 2b, 2c, 2d Conductive terminal 3, 6, 7, 10, 11 Sensor chip 4, 8, 9, 12, 13 Working electrode 4 ', 8', 9 ', 12', 13 'Counter electrode 5 Continuity monitor

Claims (4)

It has a connector which conducts with the electrode of the sensor chip having at least one pair of electrodes on one side, and the connector has two or more pairs of elastically deformable conducting terminals which are arranged to face each other in a non-contact state. , A sensor device that holds and fixes the sensor chip by the conduction terminal and conducts regardless of whether the insertion of the sensor chip is face-up or face- down,
A circuit for connecting a conductive terminal that contacts each electrode of the sensor chip when the sensor chip is inserted face up, and a conductive terminal that contacts each electrode of the sensor chip when the sensor chip is inserted face down are provided. A sensor device characterized in that a circuit to be connected is not equivalent . The conductive terminal on one side of the opposing conductive terminal makes measurable contact with only one type of sensor chip electrode out of two types of sensor chips having different electrode placement positions and / or electrode shapes, The sensor device according to claim 1 , wherein the conductive terminal on the side makes a measurable contact only with an electrode of another sensor chip. The sensor device according to claim 1 , wherein the sensor device is a biosensor device. Multiple types of sensor chips having at least a pair of electrodes on one side;
Having three or more elastically deformable conductive terminal pairs arranged to face each other in a non-contact state, and having a connector for holding and fixing the sensor chip by the conductive terminals,
Each of the sensor chips has a measurable connection with only a part of the conduction terminal,
When the sensor chip is inserted face up, a circuit that connects the conductive terminals that contact each electrode of the sensor chip is connected, and when the sensor chip is inserted face down, the conductive terminals that contact the electrodes of the sensor chip connect. A sensor device configured to be non-equivalent, and one type of sensor chip selected from the plurality of types of sensor chips is inserted in either the front side or the back side of the sensor device. In addition, the sensor chip measuring system can perform measurement by specifying the type and insertion direction of the sensor chip.

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