KR20180086301A - 기질 없는 조건 하에서 인간 배아줄기세포로부터 기능적 거핵구 및 혈소판의 대규모 생성 - Google Patents

기질 없는 조건 하에서 인간 배아줄기세포로부터 기능적 거핵구 및 혈소판의 대규모 생성 Download PDF

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KR20180086301A
KR20180086301A KR1020187021160A KR20187021160A KR20180086301A KR 20180086301 A KR20180086301 A KR 20180086301A KR 1020187021160 A KR1020187021160 A KR 1020187021160A KR 20187021160 A KR20187021160 A KR 20187021160A KR 20180086301 A KR20180086301 A KR 20180086301A
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cells
platelets
stem cells
medium
megakaryocytes
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Korean (ko)
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펭 리
쉬-지앙 루
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스템 셀 앤드 리제너러티브 메디신 인터내셔날, 인크.
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0644—Platelets; Megakaryocytes
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020187021160A 2009-12-04 2010-12-03 기질 없는 조건 하에서 인간 배아줄기세포로부터 기능적 거핵구 및 혈소판의 대규모 생성 Ceased KR20180086301A (ko)

Applications Claiming Priority (5)

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US26693909P 2009-12-04 2009-12-04
US61/266,939 2009-12-04
US38416510P 2010-09-17 2010-09-17
US61/384,165 2010-09-17
PCT/US2010/058990 WO2011069127A1 (en) 2009-12-04 2010-12-03 Large scale generation of functional megakaryocytes and platelets from human embryonic stem cells under stromal-free conditions

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KR1020127017368A Division KR20120128605A (ko) 2009-12-04 2010-12-03 기질 없는 조건 하에서 인간 배아줄기세포로부터 기능적 거핵구 및 혈소판의 대규모 생성

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KR1020197037186A Division KR20190142424A (ko) 2009-12-04 2010-12-03 기질 없는 조건 하에서 인간 배아줄기세포로부터 기능적 거핵구 및 혈소판의 대규모 생성

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KR1020187021160A Ceased KR20180086301A (ko) 2009-12-04 2010-12-03 기질 없는 조건 하에서 인간 배아줄기세포로부터 기능적 거핵구 및 혈소판의 대규모 생성
KR1020197037186A Ceased KR20190142424A (ko) 2009-12-04 2010-12-03 기질 없는 조건 하에서 인간 배아줄기세포로부터 기능적 거핵구 및 혈소판의 대규모 생성
KR1020127017368A Ceased KR20120128605A (ko) 2009-12-04 2010-12-03 기질 없는 조건 하에서 인간 배아줄기세포로부터 기능적 거핵구 및 혈소판의 대규모 생성
KR1020217016080A Ceased KR20210066020A (ko) 2009-12-04 2010-12-03 기질 없는 조건 하에서 인간 배아줄기세포로부터 기능적 거핵구 및 혈소판의 대규모 생성

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KR1020197037186A Ceased KR20190142424A (ko) 2009-12-04 2010-12-03 기질 없는 조건 하에서 인간 배아줄기세포로부터 기능적 거핵구 및 혈소판의 대규모 생성
KR1020127017368A Ceased KR20120128605A (ko) 2009-12-04 2010-12-03 기질 없는 조건 하에서 인간 배아줄기세포로부터 기능적 거핵구 및 혈소판의 대규모 생성
KR1020217016080A Ceased KR20210066020A (ko) 2009-12-04 2010-12-03 기질 없는 조건 하에서 인간 배아줄기세포로부터 기능적 거핵구 및 혈소판의 대규모 생성

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US (2) US9988603B2 (https=)
EP (1) EP2507359A4 (https=)
JP (4) JP2013512676A (https=)
KR (4) KR20180086301A (https=)
AU (4) AU2010325811A1 (https=)
BR (1) BR112012013497A2 (https=)
CA (2) CA2782013C (https=)
IN (1) IN2012DN05054A (https=)
RU (1) RU2012127810A (https=)
WO (1) WO2011069127A1 (https=)

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CN106434527A (zh) 2006-04-14 2017-02-22 安斯泰来再生医药协会 血管瘤集落形成细胞
KR20180086301A (ko) 2009-12-04 2018-07-30 스템 셀 앤드 리제너러티브 메디신 인터내셔날, 인크. 기질 없는 조건 하에서 인간 배아줄기세포로부터 기능적 거핵구 및 혈소판의 대규모 생성
SI2785359T1 (sl) 2011-11-30 2018-11-30 Astellas Institute For Regenerative Medicine Mezenhimske stromalne celice in uporabe povezane z njimi
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HK1208054A1 (en) 2012-07-12 2016-02-19 爱姆斯坦生物技术公司 Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
US9074186B2 (en) 2012-08-15 2015-07-07 Boston Medical Center Corporation Production of red blood cells and platelets from stem cells
CA2896053A1 (en) 2012-12-21 2014-06-26 Ocata Therapeutics, Inc. Methods for production of platelets from pluripotent stem cells and compositions thereof
JP6580329B2 (ja) 2014-03-31 2019-09-25 シスメックス株式会社 未分化細胞から分化細胞および／または分化細胞の産生物を取得する方法
US10538738B2 (en) 2014-05-19 2020-01-21 Eleftherios Papoutsakis Megakaryocytic particles and microparticles for cell therapy and fate modification of stem and progenitor cells
US20180237797A1 (en) * 2015-03-30 2018-08-23 Jeffrey Thomas Loh Methods for in vitro production of platelets and compositions and uses thereof
CN108697641A (zh) 2015-08-18 2018-10-23 安斯泰来再生医药协会 临床制剂
JP7287634B2 (ja) * 2015-10-14 2023-06-06 株式会社メガカリオン 精製血小板の製造方法
JP2021509812A (ja) 2018-01-05 2021-04-08 プレートレット バイオジェネシス， インコーポレイテッド 巨核球を産生するための組成物および方法
EP3813853A4 (en) 2018-06-29 2022-04-06 Platelet Biogenesis, Inc. DELIVERY COMPOSITIONS AND METHODS OF USE
US20230190815A1 (en) 2020-05-11 2023-06-22 Strm.Bio Incorporated Compositions and methods related to megakaryocyte-derived extracellular vesicles
AU2022264498A1 (en) 2021-04-26 2023-09-28 Strm.Bio Incorporated Compositions and methods related to megakaryocyte-derived extracellular vesicles for fanconi anemia

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KR20180086301A (ko) 2009-12-04 2018-07-30 스템 셀 앤드 리제너러티브 메디신 인터내셔날, 인크. 기질 없는 조건 하에서 인간 배아줄기세포로부터 기능적 거핵구 및 혈소판의 대규모 생성

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US20120315338A1 (en) 2012-12-13
AU2019203670A1 (en) 2019-06-13
AU2022200188A1 (en) 2022-02-10
EP2507359A4 (en) 2015-05-13
CA2782013C (en) 2021-06-08
US20190002829A1 (en) 2019-01-03
US9988603B2 (en) 2018-06-05
CA2782013A1 (en) 2011-06-09
JP2022064953A (ja) 2022-04-26
KR20210066020A (ko) 2021-06-04
WO2011069127A1 (en) 2011-06-09
AU2017201995A1 (en) 2017-04-13
EP2507359A1 (en) 2012-10-10
AU2017201995B2 (en) 2019-06-06
IN2012DN05054A (https=) 2015-10-09
RU2012127810A (ru) 2014-01-10
KR20120128605A (ko) 2012-11-27
JP2016135138A (ja) 2016-07-28
JP2013512676A (ja) 2013-04-18
CA3115233A1 (en) 2011-06-09
AU2019203670B2 (en) 2021-10-14
KR20190142424A (ko) 2019-12-26
BR112012013497A2 (pt) 2016-05-31
JP2019122385A (ja) 2019-07-25
AU2010325811A1 (en) 2012-06-21

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