KR20180084335A - 적색형광단백질을 발현하는 유전자 및 틴 에틸 에티오푸르푸린을 이용한 광역학 치료용 조성물 및 이를 이용한 광역학 치료방법 - Google Patents
적색형광단백질을 발현하는 유전자 및 틴 에틸 에티오푸르푸린을 이용한 광역학 치료용 조성물 및 이를 이용한 광역학 치료방법 Download PDFInfo
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- KR20180084335A KR20180084335A KR1020170007301A KR20170007301A KR20180084335A KR 20180084335 A KR20180084335 A KR 20180084335A KR 1020170007301 A KR1020170007301 A KR 1020170007301A KR 20170007301 A KR20170007301 A KR 20170007301A KR 20180084335 A KR20180084335 A KR 20180084335A
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- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
- A61M1/3683—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation using photoactive agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/067—Radiation therapy using light using laser light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0662—Visible light
- A61N2005/0663—Coloured light
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
본 발명은 적색형광단백질을 발현하는 유전자 및 틴 에틸 에티오푸르푸린을 이용한 광역학 치료용 조성물 및 이를 이용한 광역학 치료방법에 관한 것으로, 구체적으로 적색형광단백질이 도입된 암세포에 광감작제로서 틴 에틸 에티오푸르푸린(tin ethyl etiopurpurin)을 처리한 후 황색광을 조사하여 정상세포에는 영향을 미치지 않고 적색형광단백질이 도입된 암세포만을 선택적으로 사멸시킬 수 있는 광역학 치료용 조성물 및 이를 이용한 광역학 치료방법을 제공한다.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020170007301A KR101911725B1 (ko) | 2017-01-16 | 2017-01-16 | 적색형광단백질을 발현하는 유전자 및 틴 에틸 에티오푸르푸린을 이용한 광역학 치료용 조성물 및 이를 이용한 광역학 치료방법 |
PCT/KR2018/000759 WO2018131989A1 (ko) | 2017-01-16 | 2018-01-16 | 형광단백질을 발현하는 유전자 및 광감작제를 이용한 광역학 치료용 조성물 및 이를 이용한 광역학 치료방법 |
JP2019559250A JP6940185B2 (ja) | 2017-01-16 | 2018-01-16 | 蛍光タンパク質を発現する遺伝子及び光感作剤を用いた光力学治療用組成物及びこれを用いた光力学治療方法 |
CN201880007163.9A CN110198741B (zh) | 2017-01-16 | 2018-01-16 | 利用表达荧光蛋白的基因及光敏剂的光动力治疗用组合物及利用其的光动力治疗方法 |
EP18739276.6A EP3572094A4 (en) | 2017-01-16 | 2018-01-16 | COMPOSITION FOR PHOTODYNAMIC THERAPY USING A GENE EXPRESSING FLUORESCENCE PROTEIN AND A PHOTOSENSITIZER AND A PHOTODYNAMIC THERAPY PROCEDURE WITH IT |
US16/478,175 US20190365927A1 (en) | 2017-01-16 | 2018-01-16 | Composition for photodynamic therapy using gene expressing fluorescent protein and photosensitizer, and photodynamic therapy method using same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020170007301A KR101911725B1 (ko) | 2017-01-16 | 2017-01-16 | 적색형광단백질을 발현하는 유전자 및 틴 에틸 에티오푸르푸린을 이용한 광역학 치료용 조성물 및 이를 이용한 광역학 치료방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20180084335A true KR20180084335A (ko) | 2018-07-25 |
KR101911725B1 KR101911725B1 (ko) | 2018-12-28 |
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Family Applications (1)
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KR1020170007301A KR101911725B1 (ko) | 2017-01-16 | 2017-01-16 | 적색형광단백질을 발현하는 유전자 및 틴 에틸 에티오푸르푸린을 이용한 광역학 치료용 조성물 및 이를 이용한 광역학 치료방법 |
Country Status (6)
Country | Link |
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US (1) | US20190365927A1 (ko) |
EP (1) | EP3572094A4 (ko) |
JP (1) | JP6940185B2 (ko) |
KR (1) | KR101911725B1 (ko) |
CN (1) | CN110198741B (ko) |
WO (1) | WO2018131989A1 (ko) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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ES2924861T3 (es) | 2017-03-28 | 2022-10-11 | Univ Keio | Célula madre tisular humana y uso de la misma |
CN111855541A (zh) * | 2019-04-26 | 2020-10-30 | 朱德新 | 循环肿瘤细胞检测试剂、试剂盒和检测方法 |
WO2021192113A1 (ja) * | 2020-03-25 | 2021-09-30 | 大塚メディカルデバイス株式会社 | がんの処置方法およびそのためのシステム |
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KR101288460B1 (ko) | 2009-06-26 | 2013-07-26 | 주식회사 진코스 | 양자점-클로린 유도체의 접합체를 함유하는 광감작제 및 이를 포함하는 광역학 치료에 사용하기 위한 암 치료 및 진단용 조성물 |
KR101405403B1 (ko) | 2010-01-20 | 2014-06-11 | 주식회사 진코스 | 클로린 유도체와 불포화 지방산의 접합체, 이를 함유하는 광감작제, 및 이를 포함하는 광역학 치료에 사용하기 위한 암 치료용 조성물 |
KR101419124B1 (ko) | 2011-09-16 | 2014-07-11 | 가톨릭대학교 산학협력단 | 폴리에틸렌옥사이드-폴리프로필렌옥사이드 블록공중합체와 광감작제가 공유 결합된 광역학 치료용 복합체 |
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EP2189528A4 (en) * | 2007-08-03 | 2010-09-22 | Univ Hokkaido Nat Univ Corp | FLUORESCENCE PROTEIN WITH DEEP BLUE COLOR |
KR20140007976A (ko) * | 2008-05-14 | 2014-01-20 | 노바다크 테크놀러지즈 인코포레이티드 | 신경 영상 진단용 바이러스 성분들과 결합된 형광 염료를 포함하는 조성물 |
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2017
- 2017-01-16 KR KR1020170007301A patent/KR101911725B1/ko active IP Right Grant
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2018
- 2018-01-16 JP JP2019559250A patent/JP6940185B2/ja active Active
- 2018-01-16 US US16/478,175 patent/US20190365927A1/en not_active Abandoned
- 2018-01-16 CN CN201880007163.9A patent/CN110198741B/zh active Active
- 2018-01-16 EP EP18739276.6A patent/EP3572094A4/en not_active Withdrawn
- 2018-01-16 WO PCT/KR2018/000759 patent/WO2018131989A1/ko active Application Filing
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KR101288460B1 (ko) | 2009-06-26 | 2013-07-26 | 주식회사 진코스 | 양자점-클로린 유도체의 접합체를 함유하는 광감작제 및 이를 포함하는 광역학 치료에 사용하기 위한 암 치료 및 진단용 조성물 |
KR101405403B1 (ko) | 2010-01-20 | 2014-06-11 | 주식회사 진코스 | 클로린 유도체와 불포화 지방산의 접합체, 이를 함유하는 광감작제, 및 이를 포함하는 광역학 치료에 사용하기 위한 암 치료용 조성물 |
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Also Published As
Publication number | Publication date |
---|---|
EP3572094A1 (en) | 2019-11-27 |
CN110198741B (zh) | 2022-02-08 |
KR101911725B1 (ko) | 2018-12-28 |
EP3572094A4 (en) | 2020-10-21 |
JP2020513212A (ja) | 2020-05-07 |
US20190365927A1 (en) | 2019-12-05 |
JP6940185B2 (ja) | 2021-09-22 |
CN110198741A (zh) | 2019-09-03 |
WO2018131989A1 (ko) | 2018-07-19 |
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