KR20180015126A - 자폐증을 치료하기 위한 조성물 및 방법 - Google Patents

자폐증을 치료하기 위한 조성물 및 방법 Download PDF

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Publication number
KR20180015126A
KR20180015126A KR1020177032439A KR20177032439A KR20180015126A KR 20180015126 A KR20180015126 A KR 20180015126A KR 1020177032439 A KR1020177032439 A KR 1020177032439A KR 20177032439 A KR20177032439 A KR 20177032439A KR 20180015126 A KR20180015126 A KR 20180015126A
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KR
South Korea
Prior art keywords
tyrosine
methyl
administered
alpha
pyrethroid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020177032439A
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English (en)
Korean (ko)
Inventor
스티븐 호프만
Original Assignee
스티븐 호프만
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Filing date
Publication date
Priority claimed from US14/686,545 external-priority patent/US9308188B2/en
Priority claimed from US15/059,602 external-priority patent/US9763903B2/en
Application filed by 스티븐 호프만 filed Critical 스티븐 호프만
Publication of KR20180015126A publication Critical patent/KR20180015126A/ko
Withdrawn legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41661,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
KR1020177032439A 2015-04-14 2016-03-28 자폐증을 치료하기 위한 조성물 및 방법 Withdrawn KR20180015126A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US14/686,545 2015-04-14
US14/686,545 US9308188B2 (en) 2013-10-22 2015-04-14 Compositions and methods for treating intestinal hyperpermeability
US15/059,602 2016-03-03
US15/059,602 US9763903B2 (en) 2013-10-22 2016-03-03 Compositions and methods for treating intestinal hyperpermeability
PCT/US2016/024432 WO2016167944A2 (en) 2015-04-14 2016-03-28 Compositions and methods for treating intestinal hyperpermeability

Publications (1)

Publication Number Publication Date
KR20180015126A true KR20180015126A (ko) 2018-02-12

Family

ID=57126753

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020177032439A Withdrawn KR20180015126A (ko) 2015-04-14 2016-03-28 자폐증을 치료하기 위한 조성물 및 방법

Country Status (12)

Country Link
EP (2) EP3283115B1 (https=)
JP (1) JP6858131B2 (https=)
KR (1) KR20180015126A (https=)
CN (1) CN107835695B (https=)
AU (1) AU2016247301A1 (https=)
BR (1) BR112017022184A2 (https=)
CA (1) CA2982442A1 (https=)
EA (1) EA038339B1 (https=)
IL (1) IL254963A0 (https=)
MX (1) MX2017013176A (https=)
PH (1) PH12017501864A1 (https=)
WO (1) WO2016167944A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200095669A (ko) 2019-02-01 2020-08-11 스핑고브레인 주식회사 자폐증의 예측방법

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10813901B2 (en) 2013-10-22 2020-10-27 Yamo Pharmaceuticals Llc Compositions and methods for treating autism
US10751313B2 (en) 2013-10-22 2020-08-25 Yamo Pharmaceuticals Llc Compositions and methods for treating autism
WO2020018292A1 (en) * 2018-07-19 2020-01-23 Yamo Pharmaceuticals Llc Compositions and methods for treating autism
CN112789045A (zh) 2018-07-19 2021-05-11 亚莫制药有限公司 用于治疗孤独症的组合物和方法
WO2020232227A1 (en) 2019-05-14 2020-11-19 Tyme, Inc. Compositions and methods for treating cancer
US10905698B1 (en) 2020-05-14 2021-02-02 Tyme, Inc. Methods of treating SARS-COV-2 infections

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4165382A (en) * 1977-10-17 1979-08-21 Jose Pozuelo Method of pharmacologically treating schizophrenia with alpha-methyl-para-tyrosine
US6498247B2 (en) * 2000-04-13 2002-12-24 Pro-Health, Inc. Alkali or alkaline earth metal of n-butyric acid for treatment of cognitive and emotional conditions
US20060088607A1 (en) * 2004-10-01 2006-04-27 Stefano George B Nutritional supplement compositions
WO2012123819A1 (en) * 2011-03-15 2012-09-20 Optinose As Et Al Nasal delivery
PL220308B1 (pl) * 2011-06-03 2015-10-30 Kobel Buys Krystyna Zastosowanie klenbuterolu do leczenia objawów autyzmu dziecięcego oraz klenbuterol do zastosowania w leczeniu objawów autyzmu dziecięcego
WO2013103746A1 (en) * 2012-01-03 2013-07-11 Curemark, Llc Methods of treating behavioral symptoms of neurological and mental disorders
US20130183263A1 (en) * 2012-01-17 2013-07-18 Steven Hoffman Pharmaceutical compositions and methods
US20150111878A1 (en) * 2013-10-22 2015-04-23 Steven Hoffman Compositions and methods for treating intestinal hyperpermeability
US9326962B2 (en) * 2013-10-22 2016-05-03 Steven Hoffman Compositions and methods for treating intestinal hyperpermeability

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200095669A (ko) 2019-02-01 2020-08-11 스핑고브레인 주식회사 자폐증의 예측방법

Also Published As

Publication number Publication date
CA2982442A1 (en) 2016-10-20
IL254963A0 (en) 2017-12-31
JP6858131B2 (ja) 2021-04-14
EP4438059A2 (en) 2024-10-02
CN107835695B (zh) 2021-07-09
JP2018511639A (ja) 2018-04-26
WO2016167944A3 (en) 2017-08-10
EP3283115A2 (en) 2018-02-21
EP4438059A3 (en) 2025-01-01
PH12017501864A1 (en) 2018-03-05
EP3283115C0 (en) 2024-06-12
MX2017013176A (es) 2018-01-30
CN107835695A (zh) 2018-03-23
WO2016167944A8 (en) 2017-11-02
EA038339B1 (ru) 2021-08-11
AU2016247301A1 (en) 2017-10-26
EA201792278A1 (ru) 2018-04-30
BR112017022184A2 (pt) 2018-07-03
WO2016167944A2 (en) 2016-10-20
EP3283115B1 (en) 2024-06-12

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Date Code Title Description
PA0105 International application

Patent event date: 20171109

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination