KR20180003677A - 인간 성장호르몬 변이 단백질 또는 이의 트랜스페린 융합 단백질을 유효성분으로 포함하는 약학적 조성물 - Google Patents

인간 성장호르몬 변이 단백질 또는 이의 트랜스페린 융합 단백질을 유효성분으로 포함하는 약학적 조성물 Download PDF

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Publication number
KR20180003677A
KR20180003677A KR1020160082451A KR20160082451A KR20180003677A KR 20180003677 A KR20180003677 A KR 20180003677A KR 1020160082451 A KR1020160082451 A KR 1020160082451A KR 20160082451 A KR20160082451 A KR 20160082451A KR 20180003677 A KR20180003677 A KR 20180003677A
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KR
South Korea
Prior art keywords
protein
growth hormone
leu
human growth
lys
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KR1020160082451A
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English (en)
Korean (ko)
Inventor
윤정혁
장병하
김순남
정인혜
박경수
남기엽
Original Assignee
주식회사 크레아플래닛
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Priority to KR1020160082451A priority Critical patent/KR20180003677A/ko
Priority to PCT/KR2017/006953 priority patent/WO2018004294A2/fr
Publication of KR20180003677A publication Critical patent/KR20180003677A/ko

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/61Growth hormone [GH], i.e. somatotropin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79Transferrins, e.g. lactoferrins, ovotransferrins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/31Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020160082451A 2016-06-30 2016-06-30 인간 성장호르몬 변이 단백질 또는 이의 트랜스페린 융합 단백질을 유효성분으로 포함하는 약학적 조성물 KR20180003677A (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1020160082451A KR20180003677A (ko) 2016-06-30 2016-06-30 인간 성장호르몬 변이 단백질 또는 이의 트랜스페린 융합 단백질을 유효성분으로 포함하는 약학적 조성물
PCT/KR2017/006953 WO2018004294A2 (fr) 2016-06-30 2017-06-30 Composition pharmaceutique comprenant une protéine mutante d'hormone de croissance humaine ou une protéine de fusion de transferrine de celle-ci en tant qu'ingrédient actif

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020160082451A KR20180003677A (ko) 2016-06-30 2016-06-30 인간 성장호르몬 변이 단백질 또는 이의 트랜스페린 융합 단백질을 유효성분으로 포함하는 약학적 조성물

Publications (1)

Publication Number Publication Date
KR20180003677A true KR20180003677A (ko) 2018-01-10

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KR1020160082451A KR20180003677A (ko) 2016-06-30 2016-06-30 인간 성장호르몬 변이 단백질 또는 이의 트랜스페린 융합 단백질을 유효성분으로 포함하는 약학적 조성물

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KR (1) KR20180003677A (fr)
WO (1) WO2018004294A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116554343A (zh) * 2022-01-30 2023-08-08 领诺(上海)医药科技有限公司 一种长效重组人生长激素及其应用
WO2023142109A1 (fr) * 2022-01-30 2023-08-03 领诺(上海)医药科技有限公司 Hormone de croissance humaine recombinante à action prolongée et son utilisation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68929273T2 (de) * 1988-08-24 2001-07-05 American Cyanamid Co Stabilisierung von Somatotropinen durch Modifikation von Cystein-Resten durch orts-spezifische Mutagenese oder chemische Derivatisierung
JPH1192499A (ja) * 1997-09-22 1999-04-06 Sumitomo Pharmaceut Co Ltd ヒト成長ホルモン変異体
CA2787895A1 (fr) * 2010-01-22 2011-07-28 Novo Nordisk Health Care Ag Composes stables d'hormone de croissance
CN103509102B (zh) * 2012-06-15 2015-07-22 郭怀祖 野生型人生长激素突变体

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WO2018004294A2 (fr) 2018-01-04
WO2018004294A9 (fr) 2018-02-22
WO2018004294A3 (fr) 2018-08-09

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