KR20170140316A - 항-pd-1 항체를 사용한 pd-l1-양성 흑색종의 치료 - Google Patents
항-pd-1 항체를 사용한 pd-l1-양성 흑색종의 치료 Download PDFInfo
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- KR20170140316A KR20170140316A KR1020177033883A KR20177033883A KR20170140316A KR 20170140316 A KR20170140316 A KR 20170140316A KR 1020177033883 A KR1020177033883 A KR 1020177033883A KR 20177033883 A KR20177033883 A KR 20177033883A KR 20170140316 A KR20170140316 A KR 20170140316A
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70532—B7 molecules, e.g. CD80, CD86
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Applications Claiming Priority (3)
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|---|---|---|---|
| US201562153954P | 2015-04-28 | 2015-04-28 | |
| US62/153,954 | 2015-04-28 | ||
| PCT/US2016/029878 WO2016176504A1 (fr) | 2015-04-28 | 2016-04-28 | Traitement du mélanome pd-l1 positif à l'aide d'un anticorps anti-pd-1 |
Publications (1)
| Publication Number | Publication Date |
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| KR20170140316A true KR20170140316A (ko) | 2017-12-20 |
Family
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Family Applications (1)
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| KR1020177033883A KR20170140316A (ko) | 2015-04-28 | 2016-04-28 | 항-pd-1 항체를 사용한 pd-l1-양성 흑색종의 치료 |
Country Status (6)
| Country | Link |
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| US (3) | US20160362489A1 (fr) |
| EP (1) | EP3288980B1 (fr) |
| JP (3) | JP2018515474A (fr) |
| KR (1) | KR20170140316A (fr) |
| ES (1) | ES2861352T3 (fr) |
| WO (1) | WO2016176504A1 (fr) |
Families Citing this family (29)
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| US9550830B2 (en) | 2012-02-15 | 2017-01-24 | Novo Nordisk A/S | Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1) |
| BR122022015975B1 (pt) | 2012-05-15 | 2024-01-02 | Bristol-Myers Squibb Company | Anticorpos monoclonais, kit para o tratamento de um indivíduo afligido com um câncer, processo para medir pd-l1 membranoso em células tumorais isoladas e uso do anticorpo ou uma porção que se liga ao antígeno do mesmo |
| WO2016176503A1 (fr) | 2015-04-28 | 2016-11-03 | Bristol-Myers Squibb Company | Traitement du mélanome pd-l1 négatif à l'aide d'un anticorps anti-pd-1 et d'un anticorps anti-ctla-4 |
| KR20180040138A (ko) | 2015-07-13 | 2018-04-19 | 싸이톰스 테라퓨틱스, 인크. | 항pd-1 항체, 활성화 가능한 항pd-1 항체, 및 이들의 사용 방법 |
| IL293385A (en) | 2015-08-11 | 2022-07-01 | Omniab Inc | New anti–pd–1 antibodies |
| MX2018002315A (es) | 2015-09-01 | 2018-04-11 | Agenus Inc | Anticuerpos anti muerte programada 1 (pd 1) y metodos de uso de los mismos. |
| TWI795347B (zh) * | 2015-11-18 | 2023-03-11 | 美商必治妥施貴寶公司 | 使用抗ｐｄ-１抗體與抗ｃｔｌａ-４抗體之組合以治療肺癌 |
| US11291666B2 (en) | 2016-09-12 | 2022-04-05 | Intra-Cellular Therapies, Inc. | Uses |
| JP7106538B2 (ja) | 2016-12-07 | 2022-07-26 | アジェナス インコーポレイテッド | 抗体およびその使用方法 |
| ES2945745T3 (es) * | 2017-01-09 | 2023-07-06 | Tesaro Inc | Métodos de tratamiento de cánceres con anticuerpos anti-PD-1 |
| EP3589652A4 (fr) * | 2017-03-04 | 2021-05-05 | Xiangtan Tenghua Bioscience | Anticorps recombinants dirigés contre la mort programmée 1 (pd-1) et leurs utilisations |
| KR20190133213A (ko) * | 2017-03-31 | 2019-12-02 | 브리스톨-마이어스 스큅 컴퍼니 | 종양을 치료하는 방법 |
| EP3600426A4 (fr) * | 2017-03-31 | 2021-01-20 | Merck Sharp & Dohme Corp. | Compositions et procédés de traitement du cancer avec une combinaison d'un antagoniste de pd-1 et d'un anticorps anti-ctla4 |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| CN110913906A (zh) | 2017-05-02 | 2020-03-24 | 默沙东公司 | 抗lag3抗体的制剂和抗lag3抗体与抗pd-1抗体的共制剂 |
| HUE065242T2 (hu) | 2017-05-30 | 2024-05-28 | Bristol Myers Squibb Co | LAG-3-pozitív tumorok kezelése |
| CA3065304A1 (fr) | 2017-05-30 | 2018-12-06 | Bristol-Myers Squibb Company | Compositions comprenant un anticorps anti-lag-3 ou un anticorps anti-lag-3 et un anticorps anti-pd-1 ou anti-pd-l1 |
| EP3421607A1 (fr) * | 2017-06-29 | 2019-01-02 | Fundación Centro Nacional de Investigaciones Oncológicas Carlos III | Identification et élimination de cellules endommagées et/ou sénescentes |
| US20200239577A1 (en) | 2017-10-15 | 2020-07-30 | Bristol-Myers Squibb Company | Methods of treating tumor |
| WO2019083971A1 (fr) | 2017-10-23 | 2019-05-02 | Children's Medical Center Corporation | Méthodes de traitement du cancer à l'aide d'inhibiteurs de lsd1 en combinaison avec une immunothérapie |
| US11767564B2 (en) | 2017-10-27 | 2023-09-26 | Board Of Regents, The University Of Texas System | Use of SDHA as a prognostic marker and therapeutic target in uveal melanoma |
| JP2021506968A (ja) * | 2017-12-18 | 2021-02-22 | デビオファーム・インターナショナル・エス・アーＤｅｂｉｏｐｈａｒｍ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｓ．Ａ． | 癌を治療するためのアゴニスト抗ＰＤ−１抗体とＧｎＲＨアゴニスト又はアンタゴニストとの併用 |
| MA52789A (fr) | 2018-02-13 | 2021-04-14 | Merck Sharp & Dohme | Méthodes de traitement du cancer avec des anticorps anti-pd-1 |
| JP2021513540A (ja) * | 2018-02-13 | 2021-05-27 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | 抗ｐｄ−１抗体及び抗ｃｔｌａ４抗体によるがんの処置方法 |
| MX2020009552A (es) | 2018-03-21 | 2020-10-05 | Olatec Therapeutics Llc | Composiciones para prevenir y/o tratar melanoma. |
| WO2020096917A1 (fr) * | 2018-11-05 | 2020-05-14 | Merck Sharp & Dohme Corp. | Schéma posologique d'un anticorps anti-lag3 et polythérapie avec un anticorps anti-pd-1 pour le traitement du cancer |
| WO2020118208A1 (fr) * | 2018-12-07 | 2020-06-11 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Procédé de détermination du risque de développement du cancer de la peau et de prévention thérapeutique du cancer de la peau par mesure des membres de la voie de signalisation pd-1/pd-l1 |
| US20220072003A1 (en) * | 2019-01-07 | 2022-03-10 | Intra-Cellular Therapies, Inc. | Organic compounds |
| CN113244386A (zh) * | 2020-02-13 | 2021-08-13 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体在治疗肿瘤中的用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5851795A (en) | 1991-06-27 | 1998-12-22 | Bristol-Myers Squibb Company | Soluble CTLA4 molecules and uses thereof |
| US6051227A (en) | 1995-07-25 | 2000-04-18 | The Regents Of The University Of California, Office Of Technology Transfer | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US6682736B1 (en) | 1998-12-23 | 2004-01-27 | Abgenix, Inc. | Human monoclonal antibodies to CTLA-4 |
| JP4896327B2 (ja) | 1999-08-23 | 2012-03-14 | ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド | Ｐｄ−１、ｂ７−４の受容体、およびその使用 |
| US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| EP1792991A1 (fr) | 1999-08-24 | 2007-06-06 | Medarex, Inc. | Anticorps humains contre CTLA-4 et leur utilisation |
| US7034121B2 (en) | 2000-01-27 | 2006-04-25 | Genetics Institue, Llc | Antibodies against CTLA4 |
| ES2367430T3 (es) | 2002-12-23 | 2011-11-03 | Wyeth Llc | Anticuerpos contra pd-1 y sus usos. |
| CN101213297B (zh) | 2005-05-09 | 2013-02-13 | 小野药品工业株式会社 | 程序性死亡-1(pd-1)的人单克隆抗体及单独使用或与其它免疫治疗剂联合使用抗pd-1抗体来治疗癌症的方法 |
| KR101411165B1 (ko) | 2005-07-01 | 2014-06-25 | 메다렉스, 엘.엘.시. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날항체 |
| EP2007423A2 (fr) | 2006-04-05 | 2008-12-31 | Pfizer Products Incorporated | Polythérapie à base d'un anticorps anti-ctla4 |
| KR101586617B1 (ko) | 2007-06-18 | 2016-01-20 | 머크 샤프 앤 도메 비.브이. | 사람 프로그램된 사멸 수용체 ｐｄ-1에 대한 항체 |
| EP2262837A4 (fr) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | Protéines de liaison avec pd-1 |
| NZ591130A (en) | 2008-08-25 | 2012-09-28 | Amplimmune Inc | Compositions comprising a PD-1 antagonists and cyclophosphamide and methods of use thereof |
| PE20120341A1 (es) | 2008-12-09 | 2012-04-24 | Genentech Inc | Anticuerpos anti-pd-l1 y su uso para mejorar la funcion de celulas t |
| WO2011066342A2 (fr) | 2009-11-24 | 2011-06-03 | Amplimmune, Inc. | Inhibition simultanée de pd-l1/pd-l2 |
| CN103476943A (zh) | 2011-03-10 | 2013-12-25 | 普罗维克图斯药品公司 | 用于增强治疗癌症的局部和全身性免疫调节疗法的组合 |
| SI2699264T1 (en) | 2011-04-20 | 2018-08-31 | Medimmune Llc | Antibodies and other molecules that bind B7-H1 and PD-1 |
| RU2604814C2 (ru) | 2011-07-24 | 2016-12-10 | Кьюртек Лтд. | Варианты гуманизированных иммуномодулирующих моноклональных антител |
| BR122022015975B1 (pt) * | 2012-05-15 | 2024-01-02 | Bristol-Myers Squibb Company | Anticorpos monoclonais, kit para o tratamento de um indivíduo afligido com um câncer, processo para medir pd-l1 membranoso em células tumorais isoladas e uso do anticorpo ou uma porção que se liga ao antígeno do mesmo |
| MX2016003292A (es) | 2013-09-13 | 2016-06-24 | Beigene Ltd | Anticuerpos anti-muerte programada 1 y su uso como terapeuticos y diagnosticos. |
| BR122023024195A2 (pt) * | 2013-09-20 | 2023-12-26 | Bristol-Myers Squibb Company | Usos de anticorpos anti-lag-3 e anticorpos anti-pd-1 |
| CA2949121A1 (fr) | 2014-05-15 | 2015-11-19 | Bristol-Myers Squibb Company | Traitement du cancer du poumon a l'aide d'une combinaison d'un anticorps anti-pd-1 et d'un autre agent anticancereux |
| WO2016011357A1 (fr) * | 2014-07-18 | 2016-01-21 | Advaxis, Inc. | Combinaison d'un antagoniste de pd-1 et d'un vaccin à base de listeria pour le traitement du cancer |
| EP3283107B1 (fr) | 2015-04-17 | 2020-05-27 | Bristol-Myers Squibb Company | Compositions comprenant une combinaison de ipilimumab et nivolumab |
-
2016
- 2016-04-28 EP EP16724512.5A patent/EP3288980B1/fr active Active
- 2016-04-28 JP JP2017556652A patent/JP2018515474A/ja active Pending
- 2016-04-28 WO PCT/US2016/029878 patent/WO2016176504A1/fr unknown
- 2016-04-28 US US15/141,772 patent/US20160362489A1/en not_active Abandoned
- 2016-04-28 KR KR1020177033883A patent/KR20170140316A/ko not_active Application Discontinuation
- 2016-04-28 ES ES16724512T patent/ES2861352T3/es active Active
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2019
- 2019-06-03 US US16/430,106 patent/US20200010549A1/en not_active Abandoned
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2021
- 2021-03-09 JP JP2021037372A patent/JP2021105001A/ja active Pending
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2022
- 2022-03-22 US US17/701,436 patent/US20220281974A1/en active Pending
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2024
- 2024-02-09 JP JP2024018859A patent/JP2024063028A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3288980B1 (fr) | 2021-03-10 |
| JP2024063028A (ja) | 2024-05-10 |
| US20160362489A1 (en) | 2016-12-15 |
| US20220281974A1 (en) | 2022-09-08 |
| JP2021105001A (ja) | 2021-07-26 |
| EP3288980A1 (fr) | 2018-03-07 |
| JP2018515474A (ja) | 2018-06-14 |
| WO2016176504A1 (fr) | 2016-11-03 |
| ES2861352T3 (es) | 2021-10-06 |
| US20200010549A1 (en) | 2020-01-09 |
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