KR20170135416A - A chinese medicine composition and preparation method thereof - Google Patents

Abstract

A Chinese medicine composition for the treatment of gallstones comprises by weight: 70 to 175 g of Bupleurum falcatum, 110 to 120 g of Paeonia lactiflora, 130 to 135 g of Pseudostellaria heterophylla, 50 to 55 g of Poncirus trifoliata, 65 to 70 g of Lonicera japonica, 30 to 40 g of Tetrapanax papyrifer, 30 to 40 g of Auricularia auricula-judae, 20 to 25 g of Astragalus propinquus, 65 to 70 g of Codonopsis pilosula, 25 to 30 g of Scutellaria baicalensis, 40 to 45 g of Curcuma longa, 65 to 70 g of Lygodium japonicum, 140 to 150 g of Forsythia viridissima and 30 to 40 g of Taraxacum platycarpum. The Chinese medicine composition of the present invention has effects of dispersing energy of a stagnant liver to promote bile flow and promoting circulation to alleviate pain.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a Chinese medicine composition,

The present invention relates to a Chinese medicine composition for treating gallstones and a method for producing the same.

Gallstone is a common disease that occurs mainly in gallbladder and intrahepatic bile duct sites. Gallstones are primarily treated by surgical therapy, gallstone-breaking therapy, and lithogogue therapy, where both surgery and the stone therapy can be effective immediately, It has not solved the problem at all, and it can cause pain to the patient. Although the treatment of gallstones by Chinese traditional medicines has a long history and traditional Chinese medicines are getting more and more popular, there is still no Chinese medicinal composition with rapid pharmacological effect.

The present invention discloses a Chinese medicinal composition for treating gallstones, which has the effect of dispersing stagnant liver (Qi: Ki) to promote bile flow, facilitating circulation and alleviating pain, and hepatolith ) And gallstones, and has a rapid pharmacological effect.

The present invention is realized as follows: This includes by weight: Radix Bupleuri 170-175 g, Radix Paeoniae Rubra 110-120 g Radix Pseudostellariae 130-135 g, Fructus Aurantii Immaturus, Lonicera japonica, 30 to 40 g Ricepaperplant Pith, 30 to 40 g Tremella fuciformis, 20-25 g of Astragalus membranaceus, ), 65 to 70 g of Codonopsis pilosula, 25 to 30 g of Scutellaria baicalensis, 40 to 45 g of Radix Curcumae, 65 to 70 g of Lygodium japonicum, 140 to 150 g of Fructus Forsythiae ), And 30 to 40 g of dandelion. The preparation method comprises: pulverizing alum, mandarin and peony, and sieving it with a 120-mesh sieve to obtain a fine powder; Boiling the seaweed together with water, filtering to obtain a filtrate, and concentrating the filtrate to obtain a stiff paste having a relative density of 1.02 to 1.03 as measured at 60 ° C; Volatile oil is extracted by steam distillation from a mixture of glacial acetic acid, glacial acetic acid, ginseng, sugar bean ginseng, gilt earthen, golden ginseng and golden ginseng, clathration of the volatile oil with? -Cyclodextrin, compound, drying the inclusion compound, pulverizing it into a powder, and placing the powder in a container; And a mixture of dreg, ylang, kaolin, and sea liquor obtained after steam distillation with water for 1 hour for 3 hours to obtain a bath liquid, mixing the bath liquid and filtering to obtain a filtrate, And concentrated to obtain a concentrate having a relative density of 1.25 to 1.30 as measured at 60 캜, adding the above-mentioned fine granules and the fine powder of the granules, the granules and the granules, uniformly mixing, adding a 4% starch slurry, Uniformly stirring, drying, performing size stabilization, and adding volatile oil-containing compound fine powder and 1% stearic acid to make capsules, tablets or granules.

The Chinese medicine composition of the present invention has an effect of dispersing stagnant liver groups to promote bile flow and promoting circulation to alleviate pain; Can be used for the treatment of gastrointestinal stones, intrahepatic bile duct stones, and costalgia due to gallstones; Capsules, tablets or granules; Have advantages of reasonable prescription, convenient and safe dosing, rapid pharmacological effect, short term treatment process, excellent stone discharging effect, no patient suffering, and no significant toxicity and side effects.

The present invention will be explained in more detail by the following examples.

Example 1

The raw materials were weighed on a weight basis as follows: 173 g of Sepharose, 115 g of peony, 133 g of Fenugreek, 52 g of flaxseed, 68 g of gold silver, 34 g of gum, 34 g of Baek, Of gold, 41g of corn, 68g of Haegeum, 141g of bridle, and 34g of porpoise. A Chinese medicinal composition comprising the above ingredients is prepared by: pulverizing alum, mandarin, peanut and peony and sieving it with a 120 mesh sieve to obtain a fine powder; Boiling the persimmon with water, filtering to obtain a filtrate, and concentrating the filtrate to obtain a hypercholesterol having a relative density of 1.02 to 1.03 as measured at 60 ° C; The volatile oil is extracted by steam distillation of the petroleum jelly, the bean sprout, the sugar bean ginseng, the persimmon ginseng, the golden ginseng, the golden ginseng, the golden ginseng, and the gilt wolf to obtain the inclusion compound by drying the volatile oil with? -Cyclodextrin, And placing the powder in a vessel; And a mixture of the residue, ylang, white lime and sea lime obtained after steam distillation was dwelling together with water for 3 hours to obtain a bath liquid, mixing the bath liquid and filtering to obtain a filtrate, and concentrating the filtrate A dense cake having a relative density of 1.25 to 1.30 as measured at 60 캜 is obtained, and the fine powder of the above-mentioned dense granules, Drying, sizing, and adding volatile oil inclusion compound micropowder and 1% stearic acid to make capsules, tablets or granules.

Example 2

The raw materials were weighed on a weight basis as follows: 170 g Sepharose, 110 g Peony root, 130 g Prunus mume, 50 g Seaweed, 65 g Gold silver, 30 g Prunus, 30 g Baekmu, 20 g Huanggi, 65 g sugar, 25 g Of gold, 40 grams of wool, 65 grams of Haegeum, 140 grams of brassiere, and 30 grams of porpoise. A Chinese medicinal composition comprising the above ingredients is prepared by: pulverizing alum, mandarin, peanut and peony and sieving it with a 120 mesh sieve to obtain a fine powder; Boiling the persimmon with water, filtering to obtain a filtrate, and concentrating the filtrate to obtain a hypercholesterol having a relative density of 1.02 to 1.03 as measured at 60 ° C; The volatile oil is extracted by steam distillation of the petroleum jelly, the bean sprout, the sugar bean ginseng, the persimmon ginseng, the golden ginseng, the golden ginseng, the golden ginseng, and the gilt wolf to obtain the inclusion compound by drying the volatile oil with? -Cyclodextrin, And placing the powder in a vessel; And a mixture of the residue, ylang, white lime and sea lime obtained after steam distillation was dwelling together with water for 3 hours to obtain a bath liquid, mixing the bath liquid and filtering to obtain a filtrate, and concentrating the filtrate A dense cake having a relative density of 1.25 to 1.30 as measured at 60 캜 is obtained, and the fine powder of the above-mentioned dense granules, Drying, sizing, and adding volatile oil inclusion compound micropowder and 1% stearic acid to make capsules, tablets or granules.

Example 3

The raw materials were weighed on a weight basis as follows: 175 g Sepharose, 120 g of peony root, 135 g of fenugreek, 55 g of flaxseed, 70 g of gold silver, 40 g of pine needle, 40 g of white pine, Of gold, 45 grams of ugly, 70 grams of Haegeum, 150 grams of bridle, and 40 grams of porpoise. A Chinese medicinal composition comprising the above ingredients is prepared by: pulverizing alum, mandarin, peanut and peony and sieving it with a 120 mesh sieve to obtain a fine powder; Boiling the persimmon with water, filtering to obtain a filtrate, and concentrating the filtrate to obtain a hypercholesterol having a relative density of 1.02 to 1.03 as measured at 60 ° C; The volatile oil is extracted by steam distillation of the petroleum jelly, the bean sprout, the sugar bean ginseng, the persimmon ginseng, the golden ginseng, the golden ginseng, the golden ginseng, and the gilt wolf to obtain the inclusion compound by drying the volatile oil with? -Cyclodextrin, And placing the powder in a vessel; And a mixture of the residue, ylang, white lime and sea lime obtained after steam distillation was dwelling together with water for 3 hours to obtain a bath liquid, mixing the bath liquid and filtering to obtain a filtrate, and concentrating the filtrate A dense cake having a relative density of 1.25 to 1.30 as measured at 60 캜 is obtained, and the fine powder of the above-mentioned dense granules, Drying, sizing, and adding volatile oil inclusion compound micropowder and 1% stearic acid to make capsules, tablets or granules.

The 58 patients suffering from gallstones were clinically administered with capsules, tablets and granules prepared by the above method with the above prescription, and the therapeutic result was the total efficacy of the Chinese medicinal composition of the present invention for the treatment of gallstone patients 89.7%.

Clinical observations of patients administered with capsules are shown in Table 1:

Remarkable effect Mitigation effect no effect Total Effective Rate disease Number of patients Number of patients
(%) Number of patients
(%) Number of patients
(%) Number of patients
(%) gallstone 58 42 (72.4) 10 (17.3) 6 (10.3) 52 (89.7)

Claims (2)

Radix Bupleuri, 110 to 120 g Radix Paeoniae Rubra, 130 to 135 g Radix Pseudostellariae, 50 to 55 g Fructus Aurantii Immaturus, 65 to 70 g, 30 to 40 grams of Tremella fuciformis, 20 to 25 grams of Astragalus membranaceus, 65 to 70 grams of Codonopsis pilosula, 25 to 40 grams of Rice paper plant Pith, 30 to 40 grams of Ricepaper plant Pith, 30 to 40 grams of Tremella fuciformis, 20 to 25 grams of Astragalus membranaceus, 65 to 70 grams of Codonopsis pilosula, The composition of the present invention comprises 30 g of gold (Scutellaria baicalensis), 40 to 45 g of Radix Curcumae, 65 to 70 g of Lygodium japonicum, 140 to 150 g of Fructus Forsythiae and 30 to 40 g of dandelion Chinese medicine composition for gallstone treatment. A method for producing a Chinese medicine composition for treating gallstones according to claim 1, which comprises:
Pulverizing alum, alfalfa, fennel, and peony, and sieving it with a 120-mesh sieve to obtain a fine powder;
Boiling the seaweed together with water, filtering to obtain a filtrate, and concentrating the filtrate to obtain a stiff paste having a relative density of 1.02 to 1.03 as measured at 60 ° C;
Volatile oil is extracted by steam distillation from a mixture of glacial acetic acid, glacial acetic acid, ginseng, sugar bean ginseng, gilt earthen, golden ginseng and golden ginseng, clathration of the volatile oil with? -Cyclodextrin, compound, drying the inclusion compound, pulverizing it into a powder, and placing the powder in a container; And
A mixture of dreg, ylang, kaolin, and sea liquor obtained after steam distillation was dewatered three times with water for one hour to obtain a bath liquid. The bath liquid was mixed and filtered to obtain a filtrate. Concentrated to obtain a dense solution having a relative density of 1.25 to 1.30 as measured at 60 캜, adding the above-mentioned dense granules and the fine powder of dried granules, (Size stabilization), and adding volatile oil-containing compound fine powder and 1% stearic acid to make capsules, tablets or granules.