KR20170114534A - Composition for improving woman menopause symptom comprising extract of Sasa quelpaertensis Nakai - Google Patents

Abstract

The present invention relates to a composition for improving female menopausal symptoms or an agent for the prophylaxis or treatment of female menopausal diseases, which comprises an extract of Jeju Bacillus sake as an active ingredient, wherein the extract contains water, a C ₁ -C ₅ alcohol or a C ₁ -C ₅ alcohol aqueous solution And the composition can be used as a food or a pharmaceutical composition. The composition has an effect of improving body heat balance of women in menopausal age, alleviating women's menopausal symptoms or preventing or treating female menopausal diseases.

Description

TECHNICAL FIELD The present invention relates to a composition for improving the symptoms of women's menopausal symptoms,

The present invention relates to a composition for the amelioration of female menopausal symptoms comprising an extract of Jeju Soso as an active ingredient, or a composition for the prevention or treatment of female menopausal disease.

Sasa borealis Makino is the smallest bamboo among bamboos, and it grows in the mountains of the southernmost part of Korea. Sasa bamboo is one of the strongest in the bamboo, so it is effective in diabetes, hypertension, gastritis, gastric ulcer, chronic hepatitis and cancer. In addition, it is said that the bacillus has the effect of lowering heat, releasing poison, eliminating phlegm, urinating well, treating inflammation and suppressing cancer cells. Among them, Sasa quelpaertensis Nakai ) is a limited endemic species distributed only in the area of Halla Mountain. It grows in a large scale in the distribution area, and is distinguished from the feature of the inland region.

However, there have been no direct effects on the improvement of women's menopausal symptoms and the treatment and prevention of women's menopausal symptoms in relation to Sasa, especially in Jeju Sasa.

Korean Patent No. 10-0720971 Korean Patent No. 10-0672842

In view of the above problems, the inventors of the present invention have conducted studies on the extract of Jeju Soseki, and found that the extract of Jeju Sori extract has the effect of improving the female menopausal symptoms, preventing and treating the female menopausal disease and improving the body heat balance of menopausal women Which led to the present invention.

One aspect of the present invention is to provide a composition for improving female menopausal symptoms comprising an extract of Jeju Soserom as an active ingredient, or a composition for preventing or treating female menopausal disease.

An aspect of the present invention is to provide a composition for improving the body heat balance of a woman who is a menopausal woman comprising an extract of Jeju Soser as an active ingredient.

An aspect of the present invention provides a composition for improving female menopausal symptoms or preventing or treating female menopausal disease, comprising an extract of Jeju Sauce as an active ingredient.

In one aspect of the present invention, the composition is a composition further comprising a pseudo-extract.

In one aspect of the present invention, the composition further comprises at least one selected from the group consisting of Sorghum extract, Fenugreek extract, Angelica keiskei radix extract, Corn oil extract, Cinnamon extract, Lilium root extract, Fennel extract and licorice extract .

In one aspect of the invention, the extract is a water extract, a C _{1 -} C ₅ alcohol extract or a C _{1 -} C ₅ alcohol aqueous solution extract.

In one aspect of the present invention, the Jeju berry extract is a composition in an amount of 0.001 to 90% by weight based on the total weight of the composition.

In one aspect of the invention, the composition for ameliorating female menopausal symptoms is a composition that improves the body heat balance of the menopausal woman.

In one aspect of the present invention, the female climacteric symptom is selected from the group consisting of skin flushing, facial flushing, fever, sweating, limp, joint pain, muscle pain, skin elasticity reduction, skin dryness, fatigue, chest throbbing, insomnia, Headache, nervousness, vaginal discharge, vaginal dryness, vasoconstriction, intercourse pain, and sexual dyspnea.

In one aspect of the invention, the female menopausal disease is a composition that is a muscular, bone, or heart disease caused by menopause.

In one aspect of the invention, the bone disease is rheumatoid arthritis due to menopause, degenerative arthritis, osteoporosis, rickets, bone softening disease or Paget's disease of bone; Or the heart disease may be menopausal or arteriosclerosis due to menopause.

In one aspect of the invention, the composition may be a pharmaceutical composition.

In one aspect of the present invention, the composition for improving female menopausal symptoms may be a health functional food composition.

The composition according to one aspect of the present invention is effective for improving female menopausal symptoms, or for preventing or treating female menopausal symptoms.

The composition according to one aspect of the present invention has an effect of improving vaginal dryness in menopausal women.

The composition according to one aspect of the present invention has the effect of alleviating the rapid body temperature change of menopausal women.

The composition according to one aspect of the present invention has the effect of alleviating rapid body temperature rise or abrupt body temperature lowering of menopausal women.

The composition according to one aspect of the present invention has facial flushing or skin flushing effect of menopausal women.

The composition according to one aspect of the present invention has the effect of improving the inconvenience symptoms due to the hot sensation of menopausal women.

The composition according to one aspect of the present invention is effective for treating or preventing muscular diseases, bone diseases, heart diseases, skin diseases, neuropsychiatric diseases or sexual function diseases of menopausal women.

The composition according to one aspect of the present invention is useful for the prevention and treatment of menopausal symptoms such as skin flushing, facial flushing, fever, sweating, limp, joint pain, muscle pain, skin elasticity reduction, skin dryness, fatigue, chest throbbing, insomnia, It is effective to ameliorate at least one of headache, nervousness, vaginal discharge, vaginal dryness, vasoconstriction, intercourse pain and insensitivity to sex.

The composition according to one aspect of the present invention has the effect of improving body heat balance of menopausal women.

1 is a Kuppperman Index evaluation item according to Experimental Example 1 of the present invention.
2 is a menopause rating scale evaluation item according to Experimental Example 1 of the present invention.
FIG. 3A-b are photographs showing the effect of heat-relieving effect on the upper body according to Experimental Example 3 of the present invention. FIG.
Figs. 4A and 4B are photographs showing the effect of heat-relieving on the face according to Experimental Example 3 of the present invention. Fig.
Figs. 5A and 5B are photographs showing the effect of reducing the body temperature in the hand area according to Experimental Example 3 of the present invention.
6 is a quality symptom evaluation item according to Experimental Example 6 of the present invention.

Hereinafter, the present invention will be described in detail.

An aspect of the present invention provides a composition for improving female menopausal symptoms or preventing or treating female menopausal disease, comprising an extract of Jeju Sauce as an active ingredient.

In this specification "Jeju Sasa" is the scientific name Sasa quelpaertensis It is Nakai . Sasa quelpaertensis Nakai ) is a limited endemic species distributed only in the area of Halla Mountain. It grows in a large scale in the distribution area, and is distinguished from the feature of the inland region. Jeju Sori is a plant that has been used as an important nutrient for the food famine in Jeju region because it contains a lot of starch stored in fruit as a resource botanically.

As used herein, the term "extract" refers to a substance obtained by extracting a component contained therein from a natural product, regardless of the method of extraction or the kind of the component. For example, it is a broad concept including both extracts of components dissolved in a solvent from natural products using water or an organic solvent, and extracts obtained by extracting only specific components of natural products. In one embodiment of the present invention, the organic solvent is not particularly limited, and may be a C1 to C5 lower alcohol such as methanol, ethanol, isopropyl alcohol, n-propyl alcohol, n-butanol and isobutanol, Polyhydric alcohols such as ethylene glycol, propylene glycol and 1,3-butylene glycol; hydrocarbon solvents such as methyl acetate, ethyl acetate, benzene, n-hexane, diethyl ether, dichloromethane and chloroform; And nonpolar organic solvents such as benzene, hexane, chloroform, methylene chloride, dimethyl ether, ethyl acetate and the like.

In one embodiment, the extract may be an extract that is extracted using water. In another embodiment, the extract may be an extract that is extracted using a C ₁ -C ₅ alcohol. In another embodiment, the extract may be, but is not limited to, extracts extracted with ethanol.

In one aspect of the invention, the extract may be included in the composition in the form of a dried powder.

In one aspect of the present invention, the extract provides an extract obtained by using water, a C ₁ -C ₅ alcohol or a C ₁ -C ₅ alcohol aqueous solution.

In one aspect of the present invention, the composition is a composition further comprising a pseudo-extract.

In this specification, "luniscent heart" is the seed of lotus flower, and is called Nelumbinis Plumula in scientific name.

In one aspect of the present invention, the composition may further comprise at least one selected from the group consisting of Sorghum extract, Fenugreek extract, Angelica keiskei extract, Corn oil extract, Cinnamon leaf extract, A composition for preventing or treating symptoms. "Tsaja" is known as the nematode seeds, and its scientific name is Cuscuta chinensis Lam. to be. "Huropa" is known as a large yellow flower garden, and its name is Trigonella foenum - graecum L. "東方" is known as Korean angelica, and its scientific name is Angelica gigas N. "Mountain juice" is known as Hwangjae, Silasia, Stone, Chungsanjo, cornus fruit or royal jelly, and its scientific name is Cornus officinalis Siebold et Zucc . to be. In the present invention, corn oil may be corn oil. Cinnamon is also called broiler (肉桂), and its scientific name is Cinnamomum aromaticum Nees . The root is called Puerariae Radix, Pueraria lobata ( Willd .) Ohwi Or Pueraria thunbergii ( Siebold & Zucc.) Benth . Can be used. The small-scale (Foeniculi Fructus) is called Foeniculum vulgare Mill. Can be used. Licorice (licorice) is Glycyrrhiza glabra Linne can be used.

In one aspect of the invention, the extract is a water extract, a C _{1 -} C ₅ alcohol extract or a C _{1 -} C ₅ alcohol aqueous solution extract.

In one aspect of the present invention, the concentration of the aqueous C ₁ -C ₅ alcohol solution may be 40% to 90% (v / v). In one embodiment, the concentration of the aqueous C ₁ -C ₅ alcohol solution is greater than 40%, greater than 45%, greater than 50%, greater than 55%, greater than 60%, greater than 65%, greater than 66%, greater than 67%, greater than 68% , 69% or more, 70% or more, 71% or more, 72% or more, 73% or more, 74% or more, 75% or more or 80% or more. The concentration of the aqueous C ₁ -C ₅ alcohol solution may be 90% or less, 85% or less, 80% or less, 75% or less, 74% or less, 73% or less, 72% or less, 71% or less, Or less, 68% or less, 67% or less, 65% or less, or 60% or less. When the concentration of the aqueous C _{1 -} C ₅ alcohol solution is within the above range, improvement of female menopausal symptoms or treatment or prevention of female menopausal disease is excellent.

In one aspect of the present invention, the C ₁ -C ₅ alcohol is one or more selected from the group consisting of methanol, ethanol, isopropyl alcohol, n-propyl alcohol, n-butanol and isobutanol. .

In one aspect of the present invention, the Jeju berry extract is a composition in an amount of 0.001 to 90% by weight based on the total weight of the composition. In one embodiment, the Jeju bamboo sage extract may comprise from 0.1 to 60% by weight, based on the total weight of the composition. In one embodiment, the Jeju bamboo sage extract may comprise from 0.1 to 30% by weight based on the total weight of the composition. In another embodiment, the Jeju bamboo sage extract may comprise from 1 to 20% by weight based on the total weight of the composition. Specifically, the extract of Jeju Soser is selected from the group consisting of at least 0.001 wt%, at least 0.01 wt%, at least 0.1 wt%, at least 1 wt%, at least 2 wt%, at least 2.5 wt%, at least 3 wt% At least 7% by weight, at least 8% by weight, at least 8.5% by weight, at least 10% by weight, at least 13% by weight, at least 15% by weight, at least 17% by weight, at least 17.5% by weight, at least 20% % ≪ / RTI > In addition, the extract of Jeju Soser is contained in an amount of 90 wt% or less, 60 wt% or less, 50 wt% or less, 40 wt% or less, 30 wt% or less, 20 wt% or less, 19 wt% or less, 17 wt% Or less, 15 wt% or less, 10 wt% or less, 9.5 wt% or less, 8 wt% or less, 5 wt% or less, or 3 wt% or less. When the content of Jeju Sori extract is within the above range, improvement of female menopausal symptoms or treatment or prevention of female menopausal disease is excellent.

In one aspect of the present invention, the shrub core extract may be contained in an amount of 0.1 to 15% by weight based on the total weight of the composition. Concretely, the extract of Pyrrhiza extract may be present in an amount of 0.1% by weight or more, 1% by weight, 2% by weight, 2.5% by weight, 3% by weight, 5% by weight, 7% % Or more, or more than 8.5% by weight. In addition, the extract may comprise not more than 15 wt%, not more than 10 wt%, not more than 9.5 wt%, not more than 8 wt%, or not more than 5 wt%, based on the total weight of the composition. When the content of the extract is within the above range, improvement of female climacteric symptoms or treatment or prevention of female climacteric diseases is excellent.

In one aspect of the present invention, the soil extract, fenugreek extract, angelica guinea gruet extract or corn oil extract may be contained in an amount of 0.1 to 5% by weight based on the total weight of the composition. In one aspect of the present invention, the cinnamon extract or cinnamon root extract may be contained in an amount of 0.1 to 3% by weight based on the total weight of the composition. In one aspect of the present invention, the small fescue extract or the licorice extract may be contained in an amount of 0.1 to 2% by weight based on the total weight of the composition. Within the above range, when the content of the above extracts is within the above range, the improvement of the female menopausal symptoms or the treatment or prevention of the female menopausal disease is excellent .

An aspect of the present invention provides a composition comprising 50 to 150 parts by weight of the extract of Jeju Soseki and 50 to 150 parts by weight of the extract of Pseudomonas sp. As an active ingredient.

In one aspect of the present invention, there is provided a pharmaceutical composition comprising 50 to 150 parts by weight of an extract of Jeju Sauce Extract, 50 to 150 parts by weight of extracts of Psychedelic Seed Extract, 60 to 120 parts by weight of Sorghum extract, 60 to 120 parts by weight of Fenugreek extract, Wherein the composition contains 60 to 120 parts by weight of an extract of corn oil, 30 to 70 parts by weight of a cinnamon extract, 30 to 70 parts by weight of an extract of Aspergillus oryzae, 10 to 40 parts by weight of an extract of a small fir twin, and 5 to 20 parts by weight of a licorice extract as an active ingredient. Or a composition for the treatment or prevention of female menopausal diseases.

In one aspect of the invention, the composition for ameliorating the female menopausal symptoms may be a composition that is characterized by improving the body heat balance of the menopausal woman.

In one aspect of the present invention, the female climacteric symptom is selected from the group consisting of skin flushing, facial flushing, fever, sweating, limp, joint pain, muscle pain, skin elasticity reduction, skin dryness, fatigue, chest throbbing, insomnia, Headache, nervousness, decreased vaginal discharge, vaginal dryness, vasoconstriction, sexual pain, and / or impaired sexuality.

In one aspect of the invention, the female menopausal disease may be a muscular disease, bone disease or heart disease due to menopause. Specifically, the bone disease is rheumatoid arthritis, degenerative arthritis, osteoporosis, rickets, bone softening disease or Paget's disease of bone disease due to menopause; Or the heart disease may be menopausal or arteriosclerosis due to menopause.

In one aspect of the invention, the composition may be a pharmaceutical composition.

In one aspect of the present invention, the composition provides a composition formulated in the form of a powder, granule, tablet, capsule, suspension, emulsion, syrup, aerosol, external preparation, suppository and sterile injectable solution.

In one aspect of the invention, the pharmaceutical composition may further comprise, in one aspect, suitable carriers, excipients and diluents conventionally used in the manufacture of pharmaceutical compositions. In one aspect, the carrier, excipient and diluent which may be included in the composition include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, Cellulose, methylcellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil.

The pharmaceutical composition may be formulated in the form of oral, granule, tablet, capsule, suspension, emulsion, syrup, aerosol or the like, oral preparation, suppository and sterilized injection solution according to a conventional method .

In the case of formulation, a diluent such as a filler, an extender, a binder, a wetting agent, a disintegrant, a surfactant, or an excipient is usually used. Solid formulations for oral administration may include tablets, pills, powders, granules, capsules, and the like. Such solid preparations may contain at least one excipient such as starch, calcium carbonate, sucrose or lactose, and gelatin in addition to the active ingredient. In addition to simple excipients, lubricants such as magnesium stearate talc may also be included. Examples of the liquid preparation for oral use include suspensions, solutions, emulsions, syrups and the like. In addition to water and liquid paraffin which are commonly used simple diluents, various excipients such as wetting agents, sweeteners, fragrances, preservatives and the like may be included. Formulations for parenteral administration may include sterile aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations, and suppositories. Examples of the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like. Examples of suppositories include witepsol, macrogol, tween 61, laurin, cacao butter, glycerogelatin and the like.

Dosages of the extracts disclosed herein may vary depending on the condition and the weight of the patient, the degree of disease, the type of drug, the route of administration, and the period of time, and may be selected within a range generally used in the art. In one aspect, the daily dose of the active ingredient may be from 0.0001 to 0.5 g / kg on a dry weight basis, and in one aspect from 0.001 to 0.1 g / kg.

In one aspect of the invention, the composition may be a food composition.

In one aspect of the present invention, the composition for improving female menopausal symptoms may be a health functional food composition. For example, various foods, beverages, gums, tea, vitamin complexes, health supplement foods and the like can be used, and they can be used as powder, granule, tablet, capsule or beverage. The food composition of each formulation can be blended with the ingredients commonly used in the field in addition to the active ingredient without difficulty by those skilled in the art depending on the purpose of formulation or use, and synergistic effect can be obtained when the composition is applied simultaneously with other ingredients.

Here, the amount of the active ingredient contained in the food or beverage may include, but is not limited to, 0.001 to 90% by weight of the total food weight in the case of a general food composition. In the case of a health food composition, it may include 10 to 90% by weight of the total food weight, but is not limited thereto. In one aspect, the daily dosage of the active ingredient upon ingestion with the food composition may be, but is not limited to, 0.0001-0.1 g / kg on a dry weight basis.

In one embodiment, the composition may contain other ingredients, etc., which may give rise to synergistic effects on the main effect, to the extent that the main effect of the present invention is not impaired. For example, additives such as perfume, coloring agent, bactericide, antioxidant, preservative, moisturizing agent, thickening agent, inorganic salt, emulsifier and synthetic polymer substance may be further added for improvement of physical properties. In addition, it may further contain auxiliary components such as water-soluble vitamins, oil-soluble vitamins, polymer peptides, polymeric polysaccharides and seaweed extract. The above components may be mixed and selected without difficulty by those skilled in the art depending on the purpose of formulation or use, and the amount thereof may be selected within a range that does not impair the objects and effects of the present invention. For example, the addition amount of the above components may be in the range of 0.01-5 wt%, more specifically 0.01-3 wt%, based on the total weight of the composition.

The formulations of the compositions according to the present invention may be in a variety of forms such as solutions, emulsions, viscous mixtures, tablets, powders, tablets, kills, liquids, granules, pills, flakes, pastes, syrups, gels, jellies, , Which can be administered by various methods such as simple drinking, injection administration, spraying or squeezing.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are only for illustrating the present invention and that the scope of the present invention is not construed as being limited by these embodiments.

Example  1 to 3

After washing the Jeju Sauce purchased from Samyoung Food Industry Co., Ltd., the leaves of the Jeju Sage were separated. The weight ratio of the washed bamboo sake leaves to purified water is 1: 8, and the extract is taken at 95 ° C ± 2 ° C for 4 hours. The extract is cooled to 75 ° C ± 2 ° C and filtered using a microfilter (5 μm). The filtered solution is concentrated under reduced pressure to 35-40 Brix. The concentrate is dried on a spray drier to prepare a Jeju sake bran extract powder.

In the same manner as the preparation of the extract of Jeju berry, the extracts of the strawberry seeds, the strawberry, the fenugreek, the ginseng, the soybean soup, the cinnamon, the roots, the bean curd and the licorice extract were prepared.

Examples 1 to 3 were prepared with the extracts prepared as described in Table 1 below. In Table 1, excipients include tapioca starch, glycerin, honey, crystalline cellulose and sweeteners.

Example 1 Example 2 Example 3 Jeju Sori extract 700 mg 350 mg 105 mg Sumatra extract - 350 mg 105 mg Tozan extract - - 84 mg Fenugreek extract - - 84 mg Angelica extract - - 84 mg Corn oil extract - - 84 mg Cinnamon extract - - 56 mg 칡 root extract - - 56 mg Small Fibers Extract - - 28 mg Licorice extract - - 14 mg Excipient 3050 mg 3050 mg 3050 mg Total (mg) 3750 mg 3750 mg 3750 mg

The compositions of Examples 1 to 3 were prepared in the form of a 3.75 g ring, and the results were measured before and after ingestion for 1 week and 4 weeks for the subjects of the following experimental examples.

Experimental Example  One : Kuppperman  Index and MRS (Menopause Rating Scale) questionnaire evaluation

[Menopause Syndrome Questionnaire]

The Kupperman Index and the Menopause Rating Scale (MRS) are one of the typical indicators used in the menopausal syndrome questionnaire. Recently, there has been an increasing trend of clinical trials using MRS. However, The index is being used more. In other words, both the Cooperman index and the MRS are used as clinical indices in the KFDA menopausal women health functional approval. Therefore, the Cooperman index or MRS assessment against the experimenter can prove that the substance is effective in improving female menopausal symptoms, or in preventing or treating female menopausal symptoms.

Menopausal women were selected according to the following criteria.

Among women aged 47 to 56 years, menstrual irregularities during the last 6 months or amenorrhea persist for more than 2 months

- Healthy person who does not have acute and chronic physical illness including skin disease

- Those who do not get sick (cold, flu)

Women who meet the above criteria, who have received hormone therapy within the last three months, or who have undergone surgical menopause, who are taking medications to improve menopausal symptoms, or who are being treated or are taking medication , And a total of 60 women were selected as menopausal women. The ages of the selected women were 50.76 ± 2.52 years old and had an experimental period of 4 weeks.

Kuppperman  Index

This is a commonly used questionnaire to assess the symptoms of menopausal symptoms and records the severity of menopausal symptoms. The questionnaire consists of 12 questions and uses a 4-point scale (0-No, 1-little, 2-moderate, 3-severe) and the higher the score, the more severe the symptoms of menopause. The Cooperman index rating item is shown in FIG.

Examples 1 to 3 were evaluated for changes in KI score and item-specific scores before and after ingestion of the above-mentioned menopausal women.

As a result of the experiment, it was confirmed that the effect of improving the menopausal symptom was shown in the complex (Examples 1 to 3) containing the extract of Jeju Soser and the component of Jeju berry extract as shown in Table 2 below. In the case of menopausal women, the Coffman index score was lower in the case of ingestion of Examples 1 to 3 than in the case of ingestion. In particular, the effect of Example 3 was the best.

KI score Example 1 (n = 20) Example 2 (n = 20) Example 3 (n = 20) Week 0 18.12 ± 0.26 18.31 + - 0.56 18.27 ± 0.20 Week 4 14.31 + - 0.45 11.91 + 0.14 9.03 + - 0.97

MRS (Menopause Rating Scale)

This is a commonly used questionnaire to assess the symptoms of menopausal symptoms and records the severity of menopausal symptoms. The questionnaire consists of 11 questions and uses a 5-point scale (0-, 1-slight, 2-moderate, 3-severe, and 4-severe) and the higher the score, the more severe the symptoms of menopause. The MRS evaluation items are shown in Fig.

Examples 1 to 3 were evaluated for changes in MRS score and item-specific scores before and after ingestion of the menopausal women.

MRS score Example 1 (n = 20) Example 2 (n = 20) Example 3 (n = 20) Week 0 24.91 + - 3.24 25.25 ± 2.16 25.80 ± 2.83 Week 4 16.98 ± 3.03 14.98 ± 3.05 10.32 + - 2.12

As a result of the experiment, it was confirmed that the effect of improving the menopausal symptom was shown in the complex (Examples 1 to 3) containing the extract of Jeju Soser and the component of Jeju sorghum as shown in Table 3 above. In the case of menopausal women, the MRS score was lower in the case of the ingestion of Examples 1 to 3 than in the case of ingestion. In particular, the effect of Example 3 was the best.

Experimental Example 2: 24h  Measurement of body temperature change

In the case of menopausal women, frequent rapid changes in body temperature occur in everyday life, resulting in facial flushing and sleep disturbances. To confirm the improvement effect of the compositions of Examples 1 to 3, the menopausal women 60 Were measured.

To body temperature before and after the subjects have ingested the composition intakes, each of three days (72H) temperature tracker patch to the chest center ^(TM Temptraq ), And the body temperature control effect was evaluated by changing the body average temperature and standard deviation. Body temperature data are analyzed to obtain the mean body temperature and standard deviation of each subject.

Experimental Results As shown in Table 4, it was confirmed that the body temperature deviation reduction effect was improved in the composite containing the extract of Jeju Soser and the component of Jeju sorghum (Examples 1 to 3). Therefore, the compositions of the present invention were excellent in improving the body heat balance of menopausal women, and Example 3 was the most excellent.

Body Temperature Deviation (℃) Example 1 Example 2 Example 3 Week 0 2.12 + 0.08 2.08 ± 0.12 2.29 ± 0.21 Week 4 1.84 0.31 1.01 + - 0.61 0.81 ± 0.55

Experimental Example  3: Measurement of body temperature _ Confirmation of body heat balance and heat relief effect

In order to confirm the effect of relieving the heat sensation and improving the thermal balance of the body during the menopausal period, the body, face and hands were photographed using a thermal camera R300S (NEC, Japan) And skin temperature was evaluated for each site. Infrared thermal cameras always maintain constant angles and distances when shooting test sites.

Upper body, face: warming up (climacteric symptom representative inconvenience symptom) mitigation effect confirmation

The subjects who ingested the Example 1 and the Example 3 were examined for heat-relieving effect on the upper body and the face. The experimental results are shown in Figs. 3A-3B and Figs. 4A-4B. FIGS. 3A and 4A are subjects who took Example 1, and FIGS. 3B and 4B are subjects who took Example 3.

As a result of the experiment, as shown in FIG. 3 to FIG. 4, the area indicated by the red color of the body after the ingestion was reduced, indicating that there is an effect of relieving heat in the upper body and the face The more the temperature is higher).

Hand: Heat transfer It's not good.  Confirming the effect of temperature rise on the hand area measured at low temperature

The effect of temperature elevation in the hand region was confirmed by the subjects who ingested the first and third embodiments. Experimental results are shown in Figures 5a-5b. FIG. 5A is a subject who took Example 1, and FIG. 5B is a subject who took Example 3.

As a result of the experiment, it was confirmed that the temperature was raised due to the good heat transfer to the end of the body part in the case of Example 1 and Example 3, Respectively.

 As described above, when menopausal women take Examples 1 and 3 according to one aspect of the present invention, the temperature of the upper body is lowered, the temperature of the cold body is increased, and the heat balance across the body is improved The effect was confirmed.

Experimental Example  4 : Visia - CR  Using facial photography and skin of the ball area Red flag  evaluation

In order to confirm the effect of improving the reddening of the face due to the heat rise of the upper body (heat sensation), the skin color change of the facial region of 60 menopausal women taking the compositions of Examples 1 to 3 was measured. Measurements should be taken without facial flushing or sweating.

For the analysis of facial skin color change, the side of the face is photographed using a high-resolution digital camera (Visa-CR (Canfield Imaging System, USA)). Use a chin rest and a forehead rest to maintain a constant angle of view and keep the distance between the subject and the camera constant.

In order to analyze skin redness, facial photographs taken in cross-polarized mode were converted to RBX Red, and then the ball area was designated as a test area. Then, S (Saturation) was determined using an image analysis program (Image- Is derived. This means that as the S value decreases, the skin redness decreases.

Skin red (S) Example 1 Example 2 Example 3 Week 0 45.23 + - 13.09 46.04 ± 21.25 45.88 ± 18.31 Week 4 38.11 ± 9.97 37.07 ± 10.20 30.09 + - 8.79

As a result of the experiment, it was confirmed that skin redness (flushing) reduction effect was exhibited in the complexes (Examples 1 to 3) including the extract of Jeju Soser and the component of Jeju sorghum as shown in Table 5 above.

Experimental Example  5: Corneometer  Used ball site Skin moisturizing  Measure

In order to confirm the effect of improving the symptom of the skin dryness (moisture reduction) caused by the heat of the menopausal symptom, especially the heat of the facial area, the moisturization of the ball area of 60 menopausal women who took the compositions of the above Examples 1 to 3 Respectively.

Measure the skin moisturization of the ball area using a Corneometer CM825 (Courage and Khazaka, Germany). The principle of measuring the static load capacitance of the electric current passing through the electrode gap adhered to the surface of the skin is obtained by evaluating the average value obtained by measuring the moisturizing amount three times. The higher the moisture content of the skin, the higher the level.

Skin moisturizing (A.U.) Example 1 Example 2 Example 3 Week 0 63.90 ± 12.99 61.34 ± 15.10 61.87 ± 15.38 Week 4 68.30 ± 13.17 69.92 + - 14.70 73.16 ± 13.28

As a result of the experiment, it was confirmed that the moisturization of the facial area was improved in the complexes (Example 1 to 3) including the extract of Jeju Soser and the component of Jeju sorghum as shown in Table 6 above.

[ Experimental Example 6: Vaginal Symptom Survey]

A questionnaire was administered to the representative symptoms of menopausal changes in menopausal women. Sixty subjects of the menopausal women who ingested the compositions of Examples 1 to 3 were asked about the symptoms of menopausal changes in menopausal women.

The questionnaire was composed of 5 questions, and it was judged that 4 points scale (0- None, 1-little, 2-moderate, 3-severe) The evaluation items of FIG. 6 are shown in FIG.

Vaginal symptoms Example 1 (n = 20) Example 2 (n = 20) Example 3 (n = 20) Week 0 6.51 ± 3.90 6.73 ± 3.11 6.03 ± 2.97 Week 4 4.08 ± 3.01 3.81 ± 2.66 2.64 ± 2.03

As a result of the experiment, it was confirmed that the vaginal symptoms were improved in the complex (Examples 1 to 3) containing the extract of Jeju Soser and the component of Jeju sorghum as shown in Table 7 above.

Claims (11)

A composition for preventing or treating female menopausal symptoms, or a method for preventing or treating female menopausal symptoms, comprising the extract of Jeju Sosar as an effective ingredient.
The method according to claim 1,
≪ / RTI > wherein said composition further comprises a soft drink extract.
3. The method of claim 2,
Wherein the composition further comprises at least one selected from the group consisting of alum extract, fenugreek extract, Angelica keiskei extract, corn oil extract, cinnamon extract, bamboo shoot extract, bamboo shoot extract and licorice extract.
The method according to claim 1,
Wherein the extract is a water extract, a C _{1 -} C ₅ alcohol extract or a C _{1 -} C ₅ alcohol aqueous solution extract.
The method according to claim 1,
Wherein said Jeju berry extract is 0.001-90 wt.%, Based on the total weight of the composition.
The method according to claim 1,
Wherein the composition for ameliorating the female menopausal symptoms improves the body heat balance of the menopausal woman.
The method according to claim 1,
The female menopausal symptom may include skin flushing, facial flushing, fever, sweating, limp, joint pain, muscle pain, skin elasticity reduction, skin dryness, fatigue, chest throbbing, insomnia, depression, anxiety, headache, nervousness, , Vaginal dryness, vasoconstriction, intercourse pain, and / or anorexia.
The method according to claim 1,
Wherein the female menopausal disease is a muscular disease, bone disease or heart disease caused by menopause.
9. The method of claim 8,
Said bone disease is rheumatoid arthritis, degenerative arthritis, osteoporosis, rickets, bone softening disease or Paget's disease of bone disease due to menopause; or
Wherein the heart disease is menopausal or atherosclerosis due to menopause.
10. The method according to any one of claims 1 to 9,
Wherein the composition is a pharmaceutical composition.
8. The method according to any one of claims 1 to 7,
Wherein the composition for improving female menopausal symptoms is a health functional food composition.

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