KR20170077980A - Antioxidant or anti-aging composition comprising extracts of fresh sprouts of Xanthium canadense Mill. - Google Patents
Antioxidant or anti-aging composition comprising extracts of fresh sprouts of Xanthium canadense Mill. Download PDFInfo
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- KR20170077980A KR20170077980A KR1020150188025A KR20150188025A KR20170077980A KR 20170077980 A KR20170077980 A KR 20170077980A KR 1020150188025 A KR1020150188025 A KR 1020150188025A KR 20150188025 A KR20150188025 A KR 20150188025A KR 20170077980 A KR20170077980 A KR 20170077980A
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- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/302—Foods, ingredients or supplements having a functional effect on health having a modulating effect on age
Abstract
The present invention relates to a process for the production of Xanthium canadense Mill.) The present invention relates to a composition for antioxidant or anti-aging containing an extract of lycopersicum, and more particularly to a composition comprising an extract of Lycoris xanthium (DPPH) free radical scavenging, superoxide (DPPH) radical scavenging, and high molecular weight polyphenol contents were investigated in the extracts of the seeds, strumanium , corn seed, cinnamon bark, The composition containing the extract is useful as a food or health food for the purpose of antioxidant or anti-aging, since it exhibits high activity in superoxide radical scavenging, hydroxyl radical scavenging and ferric reducing / antioxidant power (FRAP) Functional foods, beverages, cosmetics and the like.
Description
The invention relates to antioxidants or anti nohwayong composition, specifically, large Xanthium strumarium (Xanthium canadense Mill.) Extracts, and beverages and foods containing them.
The basic tritiated oxygen, which is a stable molecular state generally present in the air, is a free radical which is highly reactive due to environmental and biochemical factors such as in vivo enzymes, reducing metabolism, chemicals, pollutants, It is converted to active oxygen and irreversibly destroys cellular components.
The active oxygen is an antioxidant enzyme such as superoxide dismutase (SOD), catalase, peroxidase, glutathione, and vitamin C, ascorbic acid, Vitamin E (tocopherol) can be minimized by the action of antioxidants. However, when exposed to excessively active oxygen or an abnormality in bio-defense, the balance is broken and active oxygen causes lethal oxygen toxicity to the living body.
Excessively active oxygen in the body reacts with cellular components such as lipids, proteins, sugars, and DNA to destroy it, thereby causing aging, brain diseases such as cancer, stroke and Parkinson's disease, heart disease, ischemia, atherosclerosis, , Rheumatism, autoimmune diseases, and the like.
As such oxidative stress is found to be an important cause of various diseases including aging, researches are actively conducted to develop antioxidants that remove active oxygen in vivo.
BHA (butylated hydroxy anisol) and BHT (butylated hydroxy toluene), which are widely used as synthetic antioxidants, have been widely used because of their effectiveness, economical efficiency and safety. However, not only general avoidance phenomena of synthetic additives but also gastrointestinal mucosa, lung, And it is known that it causes serious toxic effects on the environment and its usage is legally regulated.
Natural antioxidants such as tocopherol, which are harmless to humans and excellent in antioxidant activity, have been studied for a long time. However, natural antioxidants such as tocopherol are safe for human body, .
Therefore, it is urgently required to develop antioxidants that are safer and have excellent antioxidant efficacy and economic properties.
Korean Patent No. 1,056,756 discloses a cosmetic composition for antioxidant, whitening or moisturizing, which comprises as an active ingredient an extract of Sangbu, Seokchangpo, Milky white, Changbai, Hyangbuja, Nanchang, Chunma, , Which discloses the antioxidant activity of herbal medicine extracts including Tocopherol (Genus).
Korean Patent No. 1,130,245 relates to a composite herbal composition for improvement of aging comprising musk extract obtained from muskmelon and rhubarb, white blanket, angelica, chrysanthemum, gilt ewing, Free radical scavenging activity, NF-kB inhibitory effect, moisturizing effect and collagen fiber biosynthesis effect of herbal medicine extracts.
Korean Patent No. 1,315,265 discloses a mixed herbal extract which is formed by mixing a germination seed extract, a wild flower extract and a sorghum extract; The present invention relates to a composition for improving skin aging, which comprises a mixed fruit / seed extract which is formed by blending an extract of Ganoderma lucidum, Ganoderma lucidum extract, Ganoderma extract, Ganoderma extract, Ganoderma extract, And the effect of improving skin aging such as antioxidation, skin wrinkle improvement, skin whitening, and moisturizing.
In addition, in December 2013, it published in the Journal of the Korea Food and Nutrition (No. 26, No. 4, pp.609-614) has Xanthium strumarium (Xanthium strumanium ) were extracted with methanol, respectively, to examine the antioxidant activity of each region.
As always, Xanthium strumanium ) or herbal extracts containing it have existed prior art documents on the antioxidant activity, but Xanthium canadense Mill.) And the antioxidant effect of the jujitsu is not known.
The present inventors have large Xanthium strumarium (Xanthium canadense Mill.) Extract of Larvae or Larger Larvae In addition to Larvae, Larvae of Xanthium strumanium ) fruit, corn oil, cinnamon bark, crown root, yulmu seed, and jujube fruit showed excellent antioxidative effects. Therefore, the extract is safe and easy to extract from natural products, and can be used as an antioxidant composition having excellent antioxidative activity and high economic efficiency. Thus, the present invention has been completed.
It is an object of the present invention to provide a method for the production of Xanthium canadense Mill.) Extract of Larvae or Larger Larvae In addition to Larvae, Larvae of Xanthium The present invention relates to a composition for antioxidant or antioxidant containing an extract obtained by mixing strumanium fruit, cornstarch fruit, cinnamon bark, celadon root, yulmu seed, and jujube fruit, and beverages and foods containing the same.
In order to achieve the above object, the present invention is large Xanthium strumarium (Xanthium canadense Mill.) Extracts of Xanthium strumanium , cinnamon fruit, cinnamon bark, tsunami root, yulmu seed and jujube fruit in addition to lentil extract or larvae exhibit high polyphenol contents as well as free radicals free radical scavenging activity and ferric reducing / antioxidant power (FRAP) activity are also high, thereby providing an antioxidant or anti-aging composition containing the extract, a beverage and a food containing the extract.
The Xanthium canadense Mill.) Extract of Larvae or Larger Larvae In addition to Larvae, Larvae of Xanthium The extracts obtained by mixing strumium , cinnamon fruit, cinnamon, cinnamon root, yulmu, and jujube fruit were extracted by easy hot water extraction method and high polyphenol content and DPPH (2,2-diphenyl- picryl-hydrazyl) free radical scavenging, superoxide radical scavenging, hydroxyl radical scavenging and ferric reducing / antioxidant power (FRAP) Or an anti-aging composition.
Figure 1 is a schematic representation of the Xanthium canadense Mill.) Xanthium strumanium ) fruit, cornstarch fruit, cinnamon bark, crown root, yulmu seed, and jujube fruit mixture.
FIG. 2 is a flowchart illustrating a method for preparing a large-billed goat's mushroom extract according to the present invention.
FIG. 3 is a flowchart illustrating a method of preparing a mixture of a big-throat lobster, a toadstool, a cornflakes, a cinnamon bark, a tsunami root, a rhizome, and a jujube fruit extract according to the present invention.
Hereinafter, the present invention will be described in detail.
The present invention relates to a process for the production of Xanthium canadense Mill.). The present invention provides an antioxidant or an anti-aging health food containing an extract of lupine.
The large cockle extract is preferably, but not limited to, prepared by a method comprising the steps of:
1) extracting a large cockle with an extraction solvent;
2) filtering the extract of step 1);
3) concentrating the filtrate of step 2) under reduced pressure; And
4) drying the concentrate of step 3).
In the production method of the present invention, the large cockle of step 1) may be cultivated or commercially available.
In the production method of the present invention, it is preferable to use water, an alcohol or a mixture thereof as the extraction solvent in the step 1), and it is most preferable to use water for extraction. As the alcohol, C 1 to C 2 lower alcohols are preferably used, and as the lower alcohol, ethanol or methanol is preferably used. As the extraction method, it is preferable to use shaking extraction, Soxhelt extraction or reflux extraction, but not limited thereto. The extraction solvent is preferably added by 1 to 10 times the amount of the dried big horses, and it is more preferable that the extraction solvent is added by 2 to 3 times. The extraction temperature is preferably 20 ° C to 150 ° C, and most preferably 100 ° C to 125 ° C, but is not limited thereto. The extraction time is preferably 1 to 48 hours, more preferably 2 to 10 hours, most preferably 2 to 5 hours, but is not limited thereto. The number of times of extraction is preferably 1 to 5 times, more preferably 3 to 4 times, more preferably 3 times, but is not limited thereto.
The composition may exhibit activity of at least one of free radical removal and ferric reducing / antioxidant power (FRAP). More specifically, the free radical scavenging activity is DPPH 2,2-diphenyl-1-picryl-hydrazyl) free radical scavenging, Superoxide radical scavenging, or hydroxyl radical scavenging activity.
The composition was prepared by mixing Xanthium struminium ) fruit, corn oil, cinnamon bark, crown mantle root, rhizome seed, and jujube fruit.
When the above-mentioned fruit, cornstarch fruit, cinnamon bark, tsunami root, jujube seeds and jujube fruit are further mixed in the large weevil lemur, 10 to 30 parts by weight of the big weevil lemur; 5 to 25 parts by weight of dried fruit; 10 to 30 parts by weight of corn oil; 5 to 25 parts by weight of cinnamon bark; 5 to 25 parts by weight of crown root; From 2 to 22 parts by weight; And jujube fruit may be mixed in an amount of 1 to 5 parts by weight. More specifically, 15 to 25 parts by weight of Lycopersicon esculentum; 10 to 20 parts by weight; 15 to 25 parts by weight of corn oil; 10 to 20 parts by weight of cinnamon bark; 10 to 20 parts by weight of crown root; 8 to 16 parts by weight of yulmu; And jujube fruit may be mixed in 2 to 4 parts by weight.
The composition comprising the extract of a large-billed infant of the present invention, wherein the extract contains a mixture of fruit-bearing fruit, cornstarch fruit, cinnamon bark, cinnamon root, truffle seed, and jujube fruit may exhibit at least one activity . More specifically, the harmful active oxygen scavenging activity may be DPPH free radical scavenging, superoxide radical scavenging, or hydroxyl radical scavenging activity.
In a specific embodiment of the present invention, the present inventors have separately prepared extracts of Tohmari fruit, corn oil, cinnamon bark, Tangmu root, Yulmu seed and jujube fruit, respectively, As a result of confirming antioxidant activity, it was confirmed that the extract had a high polyphenol content and high activity in DPPH free radical scavenging, superoxide radical scavenging, hydroxyl radical scavenging and ferric reducing.
Accordingly, the composition comprising the extract of the present invention of the present invention or the extract obtained by mixing the fruit of the present invention, the fruit of the genus Natto, the fruit of the natto fruit, the fruit of the cinnamon, the cinnamon bark, It can be used as an anti-aging composition.
The food according to the present invention may contain an appropriate food supplementary additive in addition to a large-sized and / or big-throated young lobster extract, an extract obtained by mixing a nutritional fruit, a cornstarch fruit, a cinnamon bark, a tungsten root, a rhubarb seed and a jujube fruit .
The term "food-aid additive " in the present invention refers to a component that can be added to foods in a supplementary manner, and is appropriately selected and used by those skilled in the art as being added to produce health functional foods of each formulation. Coloring agents and fillers such as various nutrients, vitamins, minerals (electrolytes), synthetic flavors and natural flavors, colorants and fillers, pectic acid and its salts, alginic acid and its salts, organic acids, protective colloid thickeners, , A preservative, a glycerin, an alcohol, a carbonating agent used in a carbonated drink, and the like. However, the types of the food-aid additive of the present invention are not limited by the above examples.
The food is preferably a health functional food, and the health functional food refers to a food prepared and processed in the form of tablets, capsules, powders, granules, liquids, and rings using raw materials and components having useful functions for human body . Here, the term "functionality" means that the structure and function of the human body are controlled to obtain nutritional effects or effects useful for health use such as physiological actions. The health functional food of the present invention can be prepared by a method commonly used in the art and can be prepared by adding raw materials and ingredients that are conventionally added in the art. In addition, unlike general medicines, there is an advantage that there are no side effects that may occur when a medicine is taken for a long time by using food as a raw material, and it is excellent in portability. Thus, the health functional food of the present invention is excellent in antioxidant or anti- It is possible to ingest.
The amount of the active ingredient to be mixed can be suitably determined according to the intended use (prevention, health or therapeutic treatment). In general, when the food is prepared, the extract obtained by mixing the fruit of Tohomari fruit, the fruit of Sansori, the fruit of cinnamon, the fruit of the cinnamon, the fruit of Tungmu, and the jujube fruit according to the present invention, To 20% by weight, preferably 5 to 15% by weight. However, in the case of long-term ingestion intended for health and hygiene purposes or for the purpose of controlling health, the amount can also be used in the above-mentioned range.
There is no particular limitation on the kind of the food. Examples of the food to which the above substance can be added include dairy products including meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gums, ice cream, various soups, drinks, tea, Alcoholic beverages, and vitamin complexes, all of which include healthy foods in a conventional sense.
The health food of the present invention may contain various flavors or natural carbohydrates as an additional ingredient such as ordinary foods. The above-mentioned natural carbohydrates are sugar saccharides such as monosaccharides such as glucose and fructose, disaccharides such as maltose and sucrose, polysaccharides such as dextrin and cyclodextrin, and xylitol, sorbitol and erythritol. As the sweetening agent, natural sweetening agents such as tau Martin and stevia extract, synthetic sweetening agents such as saccharine and aspartame, and the like can be used. The ratio of the natural carbohydrate is generally about 0.1 to 10 g, preferably about 0.5 to 5 g per 100 g of the composition of the present invention.
The present invention also provides a beverage comprising the composition of the present invention.
In addition to the above-mentioned beverages, there are no particular limitations on the liquid component in addition to the extracts obtained by mixing the dried bean sprouts, big bean sprouts, cinnamon sprouts, cinnamon bark, Various flavors or natural carbohydrates such as beverages may be added as an additional ingredient. Examples of such natural carbohydrates include conventional saccharides such as monosaccharides such as disaccharides such as glucose and fructose such as maltose and sucrose and polysaccharides such as dextrin and cyclodextrin and xylitol such as sorbitol , Erythritol, and the like. As a flavor other than the above, a natural flavoring agent (tau Martin, a stevia compound (e.g., rebaudioside A, glycyrrhizin, etc.) and synthetic flavorings (e.g., saccharin, aspartame etc.) The ratio of the natural carbohydrate is generally about 1 to 20 g, more specifically about 5 to 12 g per 100 ml of the beverage of the present invention.
In addition, the present invention provides a pharmaceutical composition for antioxidant or anti-aging which contains a large cockle leaf extract.
The composition may further contain one or more extracts selected from the group consisting of green beans, cornflakes, cinnamon bark, crown root, yamu seed, and jujube fruit.
When the above-mentioned fruit, cornstarch fruit, cinnamon bark, tsunami root, jujube seeds and jujube fruit are further mixed in the large weevil lemur, 10 to 30 parts by weight of the big weevil lemur; 5 to 25 parts by weight of dried fruit; 10 to 30 parts by weight of corn oil; 5 to 25 parts by weight of cinnamon bark; 5 to 25 parts by weight of crown root; From 2 to 22 parts by weight; And jujube fruit may be mixed in an amount of 1 to 5 parts by weight. More specifically, 15 to 25 parts by weight of Lycopersicon esculentum; 10 to 20 parts by weight; 15 to 25 parts by weight of corn oil; 10 to 20 parts by weight of cinnamon bark; 10 to 20 parts by weight of crown root; 8 to 16 parts by weight of yulmu; And jujube fruit may be mixed in 2 to 4 parts by weight.
The composition comprising the extract of a large-billed infant of the present invention, wherein the extract contains a mixture of fruit-bearing fruit, cornstarch fruit, cinnamon bark, cinnamon root, truffle seed, and jujube fruit may exhibit at least one activity . More specifically, the harmful active oxygen scavenging activity may be DPPH free radical scavenging, superoxide radical scavenging, or hydroxyl radical scavenging activity.
In a specific embodiment of the present invention, the inventors of the present invention prepared extracts of a mixture of a big-nosed lobster extract or a big-noodle lobster, a mixture of fruit-bearing fruit, corn oil, cinnamon bark, . As a result, it was confirmed that the extract had high polyphenol content and high activity in DPPH free radical scavenging, superoxide radical scavenging, hydroxyl radical scavenging and ferric reducing.
Accordingly, the composition comprising the extract of the present invention of the present invention or the extract obtained by mixing the fruit of the present invention, the fruit of the genus Natto, the fruit of the natto fruit, the fruit of the cinnamon, the cinnamon bark, It can be used as a pharmaceutical composition for anti-aging.
The composition of the present invention can be administered orally or parenterally (e.g., applied or intravenously, subcutaneously, intraperitoneally), but oral administration is preferred. As the agent for parenteral administration, the external preparation such as powders, granules, tablets, capsules, sterilized aqueous solutions, liquid preparations, non-aqueous solutions, suspensions, emulsions, syrups, suppositories and aerosols, The composition may be formulated in the form of a cream, a gel, a patch, a spray, an ointment, a warning agent, a lotion, a liniment, a pasta or a cataplasma, , But is not limited thereto. The composition for topical administration may be anhydrous or water-based, depending on the clinical formulation. Examples of the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like. Examples of the suppository base include witepsol, macrogol, tween 61, cacao butter, laurin, glycerogelatin and the like. Solid form preparations for oral administration include powders, granules, tablets, capsules, soft capsules, and the like. Examples of liquid formulations for oral use include suspensions, solutions, emulsions, syrups and aerosols. In addition to water and liquid paraffin, which are commonly used simple diluents, various excipients such as wetting agents, sweeteners, fragrances and preservatives .
For the administration of the composition, in addition to the extracts of T. japonicus extract or L. japonica extract, which are a mixture of T. japonica fruit, C. natto fruit, C. cinerea skin, C. tsubuni root, B. japonica and jujube fruit, Or more. The pharmaceutically acceptable carrier may be a mixture of saline, sterilized water, Ringer's solution, buffered saline, dextrose solution, maltodextrin solution, glycerol, ethanol and one or more of these components. If necessary, an antioxidant, , And other conventional additives such as a bacteriostatic agent may be added. In addition, a diluent, a dispersant, a surfactant, a binder and a lubricant may be additionally added to formulate the composition for injectable use such as an aqueous solution, a suspension or an emulsion.
The pharmaceutically acceptable additives according to the present invention are preferably contained in an amount of 0.1 to 90 parts by weight based on the composition.
The preferred dosage of the composition of the present invention varies depending on the degree of absorption of the active ingredient in the body, the age of the patient, the sex, and the degree of obesity, but can be appropriately selected by those skilled in the art. However, in order to obtain the desired effect, in the case of an oral administration agent, it is generally practiced to administer the composition of the present invention to an adult at a dose of 0.0001 to 100 mg / kg per day, preferably 0.001 to 100 mg / kg per kilogram of body weight per day good. The administration may be carried out once a day or divided into several times. The dose is not intended to limit the scope of the invention in any way.
The composition of the present invention may further comprise an effective ingredient which exhibits the same or similar function, in addition to the extract of Larval toadstock or Larval toadstool, in addition to extracts of Tohomari fruit, Sansui fruit, Cinnamon bark, Tangmu root, Yulmu seed and Jujube fruit And may contain one or more species.
In addition,
(a) adding and mixing purified water of at least twice the weight of the larvae of the big-weevils; And
and (b) subjecting the mixed solution to hot water extraction at 90 to 125 캜 for 1 hour or more to prepare an antioxidant or anti-aging composition.
The step (a) may further include one or more kinds of extracts selected from the group consisting of fruit, fruit, fruit juice, cinnamon bark, root, root juice and jujube fruit. 10 to 30 parts by weight of the big-throated young louse, if further comprising said components; 5 to 25 parts by weight of dried fruit; 10 to 30 parts by weight of corn oil; 5 to 25 parts by weight of cinnamon bark; 5 to 25 parts by weight of crown root; From 2 to 22 parts by weight; And jujube fruit may be mixed in an amount of 1 to 5 parts by weight. More specifically, 15 to 25 parts by weight of Lycopersicon esculentum; 10 to 20 parts by weight; 15 to 25 parts by weight of corn oil; 10 to 20 parts by weight of cinnamon bark; 10 to 20 parts by weight of crown root; 8 to 16 parts by weight of yulmu; And jujube fruit may be mixed in 2 to 4 parts by weight. When extracting such a mixture, the amount of purified water added in step (a) may be at least twice the weight of the mixture.
Hereinafter, the present invention will be described in more detail with reference to the following Examples, Experimental Examples and Preparation Examples. It should be understood, however, that the same is by way of illustration and example only and is not intended to limit the scope of the present invention.
< Example 1> Big chick ( Xanthium canadense Mill.) Preparation of Young Seed Extract
500 g of distilled water was added to 50 g of the larvae and the mixture was extracted at 95 ° C for 5 hours. After filtration in a hot state in a vacuum filtration apparatus, the filtrate was concentrated to a solid content of 1.1% to prepare a larvae.
< Example 2> Big chick Preparation of Mixed Extracts Containing Young Seeds Extract
900 g (20% by weight) of the big thighs; Xanthium strumanium) fruit 670 g (15 wt%), Cornus fruit 900 g (20 wt%), Cinnamon Bark 670 g (15 wt%), Firmament roots 670 g (15 wt%), seeds 540 g (12% by weight of Coix) , 130 g (3% by weight) of jujube fruit and 60 L of purified water were added to a high-speed vacuum low-temperature extractor (COSMOS-660, Kyungseo machine, Incheon, Korea) and extracted at 103 ° C for 5 hours. (SPS-A430, Sungil system corp, Daegu, Korea) and packaged in a spout pouch automatic packing machine (SPS-A430, Daegu, Korea).
< Example 3> Statistical processing of experimental results
The data obtained from the experiments were expressed as mean standard deviation using the Excel program.
< Experimental Example 1> Measurement of solid content
The solid contents of the extracts or the mixed extracts prepared in Examples 1 and 2 were measured three times using a reflex curvature meter (GMK-703AC, Gi-won hightech Co., Ltd. Seoul, Korea) And repeatedly measured.
As a result, as shown in the following Table 1, it was confirmed that the solid content of the mixed extracts containing the larvae of Larger Toadlings and Larvae of Larvae was 1.10 ± 0.01% (Table 1).
1) The value is the mean value ± standard deviation (repeating experiment 3 times).
< Experimental Example 2> Total polyphenol content measurement
The content of total polyphenol compounds in the extracts prepared in Example 1 and Example 2 was measured by applying the Folin-Denis method.
Specifically, 0.2 mL of the mixed extracts of the large-sized Tochomisan japonica extract and the large-twig lotus extract prepared in Examples 1 and 2 were placed in a test tube, and 1.8 mL of distilled water and a solution of Folin-ciocalteus phenol reagent) was added, mixed, and then allowed to stand at room temperature for 3 minutes. Then, 0.4 mL of 10% Na 2 CO 3 saturated solution and 1.4 mL of distilled water were added and reacted at room temperature for 1 hour. Absorbance of the supernatant was measured at 700 nm. Caffeic acid was prepared at a concentration of 0 ~ 100 g / mL and analyzed by the same method as the sample. The total phenol content of the extract was calculated from the standard calibration curve.
As a result, as shown in the following Table 2, the polyphenol content of the larvae of the Larvae was 20.15 ± 4.51 mg%, and the polyphenol content of the mixed extracts containing Larvae Larvae was 33.90 ± 3.19 mg% (Table 2).
1) The value is the mean value ± standard deviation (repeating experiment 3 times).
< Experimental Example 3> DPPH Free radical Scatters Confirm
DPPH (2,2-diphenyl-1-picryl-hydrazyl) free radical In order to confirm the scavenging activity, 0.4 mL of each of the mixed extracts containing the big-throated farinacea extract and the big-throated farinacea extract prepared in Examples 1 and 2 was added to 1 x 10-4 5.6 mL of M DPPH solution (methanol) was added, and the solution was allowed to stand for 10 minutes, and the absorbance was measured at 525 nm. At this time, ascorbic acid was used as a positive control standard for the activity comparison, and the DPPH free radicals Respectively.
As a result, as shown in Table 3 below, the DPPH radical scavenging ability of the mixed extract containing the larvae of Larvae was 73.64 ± 1.38%, which was measured at a concentration of 75 μg / mL of the positive control ascorbic acid (DPPH) radical scavenging activity (67.85 ± 2.82%). In addition, DPPH radical scavenging activity was 42.71 ± 2.24%, indicating that DPPH extract showed significant antioxidant activity (Table 3).
1) The value is the mean value ± standard deviation (repeating experiment 3 times).
< Example 4> Superoxide ( Superoxide ) Radical Scatters
In order to confirm superoxide radical scavenging ability, 0.25 mL of each of the mixed extracts containing the large-sized Tochoma japonica extract prepared in Example 1 and Example 2, and the large-sized Tochoma japonica extract was added to 30 mM tris-hydrogen chloride To this solution, add 50 μL of buffer (Tri-HCl buffer, pH 8.0), 100 μL of 0.1 mM phenazine methosulfate (PMS), 200 μL of 0.5 mM nicotinamide adenine dinucleotide (NADH) 100 μL of nitrotetrazolium blue chloride (NBT) was mixed and allowed to stand at 37 ° C for 10 minutes, and the absorbance was measured at 560 nm. At this time, ascorbic acid was used as a positive control standard for the activity comparison, and superoxide radical scavenging ability was shown by the absorbance ratio of the addition group to the no-added group.
As a result, as shown in Table 4, the superoxide radical scavenging activity of the mixed extract containing the larvae of Larvae was 56.61 ± 1.85%, indicating that the positive control group, ascorbic acid, at a concentration of 250 μg / mL (56.97 ± 0.24%) of the measured superoxide radical scavenging activity. Therefore, it was confirmed that the mixed extract containing the larvae of the larvae showed remarkable superoxide radical scavenging activity. In addition, it was also confirmed that the superoxide radical scavenging activity of the larvae of the larvae was 34.38 ± 4.08%, indicating superoxide radical scavenging activity (Table 4).
1) The value is the mean value ± standard deviation (repeating experiment 3 times).
< Example 5> Hydroxyl (Hydroxyl) Radical Scatters
Hydroxyl To confirm the radical scavenging activity, 0.2 mL of 10 mM FeSO 4 · 7H 2 O / EDTA solution, 0.2 mL of 10 mM 2-deoxyribose, 0.2 mL of sample, and 0.1 M sodium phosphate buffer pH 7.4) and 0.2 mL of 10 mM H 2 O 2 in that order, followed by reaction at 38 ° C for 1 hour. Then, 1 mL of 10% TCA solution and 1 mL of 1% TBA were added, heated at 95 ° C for 10 minutes in a water bath, quenched, and absorbance measured at 532 nm. At this time, ascorbic acid was used as a positive control standard for the activity comparison, and the hydroxyl radical scavenging ability was shown by the absorbance ratio of the addition group to the sample-free addition group.
As a result, as shown in Table 5, the hydroxyl radical scavenging ability of the mixed extract containing the larvae of Larvae was 33.46 ± 4.22%, which was measured at a concentration of 5 mg / mL of ascorbic acid as a positive control (29.06 ± 1.10%) than that of the control group. Thus, the mixed extract containing the larvae of the larvae has excellent hydroxyl Radical scavenging ability. In addition, it was confirmed that the larvae of L. japonica showed a hydroxyl radical scavenging ability of 8.52 ± 3.74% (Table 5).
1) The value is the mean value ± standard deviation (repeating experiment 3 times).
< Experimental Example 5> ferric reducing / antioxidant power, FRAP ) Active (reducing power)
To measure ferric reducing activity, 0.2 M sodium phosphate buffer (pH 6.6) and 1% potassium ferricyanide were added in the order of 1 mL, followed by reaction at 50 ° C for 20 minutes. Then add 1 mL of 10% TCA solution and centrifuge at 2,000 rpm for 15 minutes. Add 0.1 mL of ferric chloride (FeCl 3 ) to 1 mL of supernatant and 1 mL of distilled water. And the absorbance was measured at 700 nm. At this time, ascorbic acid was used as a standard substance for positive control for activity comparison, and the reducing power was expressed by absorbance value.
As a result, as shown in Table 6, the absorbance of the mixed extract containing the larvae of Larvae was 2.307 ± 0.034, which was the absorbance at the concentration of 200 μg / mL of ascorbic acid (2.316 ± 0.018%) than the others. Therefore, it was confirmed that the mixed extracts containing the larvae of the larvae showed excellent reducing power. In addition, it was confirmed that the extract of L. japonica showed a reducing power by showing an absorbance of 1.324 ± 0.027 (Table 6).
1) The value is the mean value ± standard deviation (repeating experiment 3 times).
< Manufacturing example 1> Manufacture of Flour Food
1 to 20.0 parts by weight of a mixed extract powder containing the large-throat larva extract of the present invention or the large-edible larvae extract of the present invention is added to wheat flour, and the mixture is used to prepare bread, cake, cookie, cracker and noodle.
< Manufacturing example 2> soup And juices
1 to 20.0 parts by weight of a mixed extract powder containing the large-throat larva extract of the present invention or the large-throated larva extract of the present invention is added to the soup and the juice to prepare a meat product for health promotion, soup of the noodle and juice.
< Manufacturing example 3> Manufacture of dairy products
5 to 10 parts by weight of a mixed extract powder containing the large-throat larvae extract of the present invention or the large-throated larvae extract of the present invention was added to milk, and various dairy products such as butter and ice cream were prepared using the milk.
< Manufacturing example 4> Manufacture of Health Functional Foods
20 ㎎ of the mixed extract powder containing the large doenjang extract of the present invention or the large doejang extract, 70 ㎍ of vitamin A acetate, 0.1 mg of vitamin B1, 0.15 mg of vitamin B2, 0.5 mg of vitamin B6, 0.2 mg of vitamin B12, 10 mg of vitamin C, 10 mg of biotin, 1.7 mg of nicotinic acid amide, 50 mg of folic acid, 0.5 mg of calcium pantothenate, 1.75 mg of ferrous sulfate, 0.82 mg of zinc oxide, 25.3 mg of magnesium carbonate, 15 mg of potassium phosphate monohydrate, 55 mg of calcium dihydrogenphosphate, 90 mg of potassium citrate, 100 mg of calcium carbonate and 24.8 mg of magnesium chloride are mixed to prepare a general health food.
< Manufacturing example 5> Manufacture of health drinks
A method for preparing a conventional health drink by mixing 20 mg of a mixed extract powder comprising a large doenjang extract of the present invention or a large doenjang extract of the present invention, 1,000 mg of citric acid, 100 g of oligosaccharide, 2 g of a plum concentrate, 1 g of taurine, .
Claims (10)
Wherein the extract is a hot-water extract.
Wherein the composition exhibits a free radical scavenging activity or a ferric reducing / antioxidant power (FRAP) activity.
Xanthium wherein the extract further comprises at least one extract selected from the group consisting of alfalfa , alfalfa , alfalfa , alfalfa , alfalfa , alfalfa , alfalfa , alfalfa ,
10 to 30 parts by weight of Larvae; 5 to 25 parts by weight of a nutella fruit; 10 to 30 parts by weight of corn oil; 5 to 25 parts by weight of cinnamon bark; 5 to 25 parts by weight of celadon root; 2 to 22 parts by weight of rhizome seeds; And 1 to 5 parts by weight of jujube fruit.
Said mixture comprising 15 to 25 parts by weight of a larva; 10 to 20 parts by weight of a nutrient fruit; 15 to 25 parts by weight of corn oil; 10 to 20 parts by weight of cinnamon bark; 10 to 20 parts by weight of root crown; 8 to 16 parts by weight of yulmu; And 2 to 4 parts by weight of jujube fruit.
Wherein the composition exhibits at least one activity of removing harmful free radicals and reducing ferric reducing / antioxidant power (FRAP).
Wherein the composition further comprises at least one extract selected from the group consisting of fruit, fruit juice, cinnamon bark, root, root, fruit juice and jujube fruit.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020150188025A KR20170077980A (en) | 2015-12-29 | 2015-12-29 | Antioxidant or anti-aging composition comprising extracts of fresh sprouts of Xanthium canadense Mill. |
| KR1020180027007A KR102306737B1 (en) | 2015-12-29 | 2018-03-07 | Antioxidant food comprising extracts of fresh sprouts of Xanthium canadense Mill. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020150188025A KR20170077980A (en) | 2015-12-29 | 2015-12-29 | Antioxidant or anti-aging composition comprising extracts of fresh sprouts of Xanthium canadense Mill. |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020180027007A Division KR102306737B1 (en) | 2015-12-29 | 2018-03-07 | Antioxidant food comprising extracts of fresh sprouts of Xanthium canadense Mill. |
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| Publication Number | Publication Date |
|---|---|
| KR20170077980A true KR20170077980A (en) | 2017-07-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| KR1020150188025A KR20170077980A (en) | 2015-12-29 | 2015-12-29 | Antioxidant or anti-aging composition comprising extracts of fresh sprouts of Xanthium canadense Mill. |
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| Country | Link |
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| KR (1) | KR20170077980A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210047588A (en) * | 2019-10-22 | 2021-04-30 | 국립낙동강생물자원관 | Skin-lightening Composition Using an Extract of Xanthium canadense |
| KR102606838B1 (en) * | 2023-01-20 | 2023-11-29 | 그린코스 주식회사 | Antioxidative and antiinflammatory compostion comprising the extract of plant root |
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2015
- 2015-12-29 KR KR1020150188025A patent/KR20170077980A/en active Search and Examination
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210047588A (en) * | 2019-10-22 | 2021-04-30 | 국립낙동강생물자원관 | Skin-lightening Composition Using an Extract of Xanthium canadense |
| KR102606838B1 (en) * | 2023-01-20 | 2023-11-29 | 그린코스 주식회사 | Antioxidative and antiinflammatory compostion comprising the extract of plant root |
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