JP6397550B1 - Constitution improver - Google Patents

Abstract

An object of the present invention is to provide a constitution improving agent containing a natural-derived highly safe active ingredient that has an excellent improving effect on symptoms such as daily fatigue and can be continuously ingested. [Solution] A constitution improving agent comprising plants of Lingonberry (also known as bilberry) and Amla (also known as citrus, oil citrus, ammarok, Indian gooseberry) or an extract thereof. [Selection] Figure 1

Description

  The present invention relates to a constitution improving agent useful for foods or pharmaceuticals, which contains plants of Lingonberry (Vaccinium vitis-idaea) and Amla (Phyllanthus emblica or Emblica officinale) or extracts thereof.

  Many working people suffer from fatigue, dullness, chronic gastrointestinal discomfort, sleep deprivation, etc. Especially women have symptoms such as cold limbs and skin problems in addition to these symptoms. , Has become a daily trouble.

  Kampo medicine is often taken to comprehensively relieve or treat such daily and chronic symptoms, but the effect gradually appears after long-term use, and prompt improvement of symptoms is sought. It is difficult.

  On the other hand, it is possible to take western medicine for each symptom, but it is difficult to take it as a preventive medicine on a daily basis, and there is a risk that adverse effects such as side effects will occur if taken for a long time. It is done.

  For this reason, it is necessary to develop a constitution improving agent that has an excellent effect on daily symptoms such as fatigue and that contains a naturally-derived and safe active ingredient that can be continuously taken orally. .

JP 2009-292738

  The object of the present invention is to provide a constitution improving agent containing a naturally occurring and highly safe active ingredient that has an excellent improving effect on symptoms such as daily fatigue and can be continuously ingested. There is to do.

As a result of intensive studies to solve the above problems, the present inventor has found that the Vaccinium genus Vaccinium (Vaccinium vitis-idaea) and the Euphorbiaceae Emblica Amla (Phyllanthus emblica or Emblica) The present inventors have found that fatigue, sleep, swelling, stiff shoulders, and cold hands and feet are effectively improved when an officinale) plant or an extract thereof is continuously taken, and the present invention has been completed.

That is, the present invention comprises fatigue, sleep, swelling, stiff shoulders, limbs or limbs characterized by containing plant bodies of Lingonberry (Vaccinium vitis-idaea) and Amla (Phyllanthus emblica or Emblica officinale) or extracts thereof. It is a constitution improving agent for improving any of the cold .

According to the constitution-improving agent of the present invention, when taken continuously, it effectively improves fatigue, sleep, swelling, stiff shoulders, or cold limbs, and maintains a healthy and good state. Is possible.

Graph showing the effect of constitution improvement

  The constitution improving agent of the present invention is obtained from a Vaccinium lingonberry (Vaccinium vitis-idaea) that can be taken orally and an Amla (Phyllanthus emblica or Emblica officinale). The obtained plant body or its extract is contained as an active ingredient.

  Lingonberry (Vaccinium vitis-idaea), also known as cowberry, is known to be abundant in the Arctic Circle of Canada and Canada, and is rich in vitamin C and citric acid. Fruits are eaten raw and are commonly used in processed foods such as juice and jam.

  The part of the lingonberry used in the present invention is not particularly limited, but can be arbitrarily used for fruits (immature fruit, ripe fruit, dried fruit), leaves, tuberous roots, flowers, seeds and the like. Of these, fruits are preferably used.

  The lingon berries used in the present invention can be used as raw or dried, but are preferably used as a dry powder or a solvent extract from the viewpoints of usability and formulation.

  As a method for obtaining a dry powder, various parts of plants (fruits, leaves, tuberous roots, flowers, seeds, etc.) or whole plants are shredded or pulverized, and then dried or chopped or ground after the plants are dried. There is a method to obtain a dry powder. Moreover, after chopping or grinding | pulverizing a plant, performing fermentation or an enzyme treatment, it can dry, and also the method of grind | pulverizing so that it may become a predetermined particle size as needed can be taken suitably.

  The extract of lingonberry can be obtained by a conventional method. For example, after the lingonberry is dried as necessary, it is immersed in an extraction solvent for a certain period of time, or is contacted with an extraction solvent that is heated to reflux, and then filtered. It can be obtained by concentrating. As the extraction solvent, any solvent that is usually used for extraction can be used. For example, water, methanol, ethanol, propylene glycol, 1,3-butylene glycol, glycerol and other alcohols, chloroform, dichloroethane, four Organic solvents such as carbon chloride, acetone and ethyl acetate can be used alone or in combination. The extract obtained by extraction with the above solvent is used as it is, or concentrated extracts are used, or these extracts are removed by using an adsorption method, for example, ion exchange resin, or a porous polymer (for example, Amberlite XAD- After adsorbing on the column of 2), elution with methanol or ethanol and concentration can also be used. Further, a partitioning method, for example, an extract extracted with water / ethyl acetate can be used. The lingonberry extract is commercially available, for example, as “Lingonberry extract” (manufactured by Oriza Oil Chemical Co., Ltd.), and these commercially available products may be used.

  Amla (Phyllanthus emblica or Emblica officinale) used in the present invention is a deciduous sub-tree belonging to the genus Emblica, distributed from India to Malaysia and southern China, and is considered to be the origin of India . Amla has a unique name depending on each region or language, and is also called, for example, citrus citrus, oil citrus, ammarok, malach, Indian gooseberry, and the like.

  The use site of Amla is not particularly limited, and can be used arbitrarily such as fruits (immature fruits, ripe fruits, dried fruits), leaves, tuberous roots, flowers, seeds, among which fruits are preferably used. .

  Amla can be used raw or dried, but it is preferably used as a dry powder or a solvent extract from the viewpoints of usability and formulation. The method for obtaining the dry powder or the extract is not particularly limited, and the method described in the above lingon berry can be employed. Amla extract is also commercially available, for example, as “San Amla” from Taiyo Kagaku Co., Ltd., and these commercially available products may be used.

  The constitution improving agent of the present invention can be mixed with various foods and drinks and taken as food, and can be administered as a pharmaceutical preparation.

  The constitution improving agent of the present invention can be obtained by blending various lingon berry and amla plants or extracts thereof into various foods and drinks, but in the mass production process, the constitution improving agent is used as an in-process item. You may mix | blend with various food-drinks.

  The amount of Lingonberry and Amla to be ingested (administered) can be appropriately determined according to the method of ingestion (administration), dosage form, etc., but the amount of ingestion (administration) per day can be determined in terms of dry mass. 0.1 mg to 10 g, preferably 1 to 1000 mg, most preferably 10 to 100 mg. Amla is prepared to 0.1 mg to 10 g, preferably 1 to 1000 mg, most preferably 10 to 100 mg. It is desirable.

  When mix | blending the constitution improving agent of this invention with food-drinks, an additive can be arbitrarily selected as needed and used together. As additives, functional materials, excipients, and flavoring agents can be included.

  Functional materials include various vitamins such as pantothenic acid, folic acid and biotin, various minerals such as zinc, calcium, magnesium and iron, amino acids, oligosaccharides, propolis, royal jelly, ginkgo biloba, turmeric, EPA, DHA, coenzyme Q10, Chondroitin, lactic acid bacteria, lactoferrin, isoflavone, prunes, chitin, chitosan, glucosamine, α-lipoic acid, agaricus, garcinia, propolis, collagen, astaxanthin, forthrin, catechin, sesamin, ceramide, moroheiya, spirulina, cats claw, etc. . These functional materials can be used alone or in combination of two or more.

  The excipient may be anything that is usually used in the desired dosage form, for example, starches such as wheat starch, rice starch, corn starch, potato starch, dextrin, cyclodextrin, and crystalline celluloses. , Sugars such as lactose, glucose, sugar, reduced maltose, starch syrup, fructooligosaccharide, emulsified oligosaccharide, and sugar alcohols such as sorbitol, erythritol, xylitol, lactitol, mannitol. These excipients can be used alone or in combination of two or more.

  As a flavoring agent, various fruit juice extracts such as Bontang extract, lychee extract and yuzu extract, various fruit juices such as apple juice, orange juice and lemon juice, various flavors such as peach flavor, ume flavor and yogurt flavor, acesulfame K, sucralose , Erythritol, oligosaccharides, mannose, xylitol, isomerized sugars, and other sweeteners, citric acid, malic acid, tartaric acid, gluconic acid, and other acidulants, green tea, oolong tea, banaba tea, Tochu tea, iron kannon tea, pearl barley Various tea ingredients such as tea, amacha mul tea, macomo tea, and kelp tea are listed. These taste agents can be used alone or in combination of two or more.

  Other colorants, preservatives, thickeners, binders, disintegrants, dispersants, stabilizers, gelling agents, antioxidants, surfactants, preservatives, pH adjusters, etc. A known one to be used can be appropriately selected and used.

  The form of the food or drink can be arbitrarily selected from, for example, liquid, solid, granule, granular, paste, and gel.

  Specific examples of foods and beverages include, for example, fruit juice beverages, vegetable juices, soft drinks, beverages such as tea, soups, pudding, yogurt, cake premix products, confectionery, cookies, candy, gummi, gum, and other general processing In addition to foods, food supplements such as drinks, foods and drinks for specified health use, functional foods and drinks, and health foods and drinks are included. However, it is not limited to these examples.

  When the constitution improving agent of the present invention is used as a pharmaceutical preparation, the dosage form can be appropriately selected. For example, it can be a solid preparation such as a tablet, a granule, a powder or a capsule, or a liquid preparation such as an internal solution or a syrup. These pharmaceutical preparations include commonly used binders, disintegrants, thickeners, dispersants, reabsorption accelerators, taste-masking agents, buffers, surfactants, solubilizers, preservatives, emulsifiers, Excipients such as isotonic agents, stabilizers and pH adjusters may be used as appropriate.

  Hereinafter, although the test and result which were performed in order to confirm the effect of the present invention are explained in detail, the present invention is not limited to the following test examples or examples.

  A panel test was conducted, and the effects of the present invention were confirmed by the following tests. In the continuous test, four types of test samples (drinks) were prepared and divided into groups A to D. The number of panelists is A group 39 people, B group 8 people, C group 14 people, D group 39 people. Each paneler took a test sample (drink) by ingestion once a day.

  Table 1 shows the formulation of the test sample (drink).

Test 1 “Questionnaire Evaluation”
(Test method)
Before the start of the continuous test and 28 days after the start of the continuous test, “Ease of fatigue”, “Degree of recovery from fatigue”, “Ease of waking up in the morning”, “Sleep well”, “Heavily heavy”, “Muscle pain” Surveys were conducted on items related to ease, swelling of feet, swelling of morning faces, stiff shoulders, cold limbs, hot flashes and hot flashes, and hangover proneness. did.

  The questionnaire was evaluated by VAS (abbreviation for visual analogue scale) which is widely used as an evaluation scale. That is, on each survey day, a paper describing a straight line drawn in a 10 cm horizontal line is distributed to the subjects, and the left end of the straight line is “worst state” and the right end is “best state”. Was entered as a position on the straight line (subject marked a place on the line segment), and the distance moved to the right (or left) from the test start position was evaluated as a scale value. In addition, statistical analysis for verifying the difference between groups was performed by Tukey.

  As shown in FIG. 1, Group D (Lingonberry and Amla combination) is all compared to Group A (placebo), Group B (Amla alone combination), and Group C (Lingonberry alone combination). It was confirmed that an excellent effect was exhibited in the item.

Table 2 shows the results of statistical analysis of the differences between group A (placebo), group B (amla alone), group C (lingonberry alone), and group D (lingonberry and amla). . In the table, *** indicates a significant difference with significance probability p <0.001, ** indicates a significant difference with significance established p <0.01, * indicates a significant difference with significance probability p <0.05, + indicates a significance probability p <0.1. It shows that a significant trend difference was observed.

  From the results of Table 2, it was recognized that the D group (containing Lingonberry and Amla) was significantly different from the A group (placebo) in all items. In addition, Group D (Lingonberry and Amla combination) is significantly different from Group B (Amla alone) and Group C (Lingonberry alone) in almost all items. The synergistic effect by combining lingonberry and amla could be confirmed.

  Although the example of a constitution improving agent other than a drink is shown below, these are only examples and do not limit the present invention.

Formulation Example 1: Tablet (for 1 day)
(1) Lingonberry extract (dry mass conversion) 25mg
(2) Amla extract (dry mass conversion) 30mg
(3) Adjusted oil (contains jar E) (processed starch) 36mg
(4) Vitamin C 200mg
(5) Vitamin B2 8mg
(6) Vitamin B6 20mg
(7) Sucrose ester 40mg
(8) Crystalline cellulose 126mg
(9) Cornstarch proper amount total 2g

Formulation Example 2: Capsule (for 1 day)
(1) Lingonberry extract (dry mass conversion) 25mg
(2) Amla extract (dry mass conversion) 30mg
(3) Calcium stearate 24mg
(4) Silicon dioxide 12mg
(5) Appropriate amount of starch
(6) Encapsulation 192mg
Total 1.2g

Formulation Example 3: Jelly (for 1 day)
(1) Lingonberry extract (dry mass conversion) 25mg
(2) Amla extract (dry mass conversion) 30mg
(3) Erythritol 6.75g
(4) Gelling agent 1.35g
(5) Vitamin C 360mg
(6) Vitamin B2 0.75mg
(7) Vitamin B6 0.75mg
(8) Sweetener 45mg
(9) Acidulant 195mg
(10) Fragrance 165mg
(11) Appropriate amount of purified water 150g in total

Claims (1)

Any of fatigue, sleep, swelling, stiff shoulders, or cold limbs , characterized by containing Lingonberry (Vaccinium vitis-idaea) and Amla (Phyllanthus emblica or Emblica officinale) plants or extracts thereof Constitution improver to improve.

Images