KR20170075775A - 백신 및 진단제 개발을 위한 재조합 뎅기 바이러스에 대한 방법 및 조성물 - Google Patents

백신 및 진단제 개발을 위한 재조합 뎅기 바이러스에 대한 방법 및 조성물 Download PDF

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KR20170075775A
KR20170075775A KR1020177014337A KR20177014337A KR20170075775A KR 20170075775 A KR20170075775 A KR 20170075775A KR 1020177014337 A KR1020177014337 A KR 1020177014337A KR 20177014337 A KR20177014337 A KR 20177014337A KR 20170075775 A KR20170075775 A KR 20170075775A
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glycoprotein
dengue virus
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gly
thr
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랄프 배릭
더글라스 위드맨
보이드 욘트
에밀리 갈리초트
스코트 로열
아라빈다 데실바
제시카 스완스트롬
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더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • C07K16/10—RNA viruses
    • C07K16/112—Retroviridae (F), e.g. leukemia viruses
    • C07K16/114—Lentivirus (G), e.g. human immunodeficiency virus [HIV], feline immunodeficiency virus [FIV] or simian immunodeficiency virus [SIV]
    • C07K16/1145—Env proteins, e.g. gp41, gp110/120, gp160, V3, principal neutralising domain [PND] or CD4-binding site
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
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KR1020177014337A 2014-11-02 2015-11-02 백신 및 진단제 개발을 위한 재조합 뎅기 바이러스에 대한 방법 및 조성물 Withdrawn KR20170075775A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462074053P 2014-11-02 2014-11-02
US62/074,053 2014-11-02
PCT/US2015/058610 WO2016070178A1 (en) 2014-11-02 2015-11-02 Methods and compositions for recombinant dengue viruses for vaccine and diagnostic development

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KR20170075775A true KR20170075775A (ko) 2017-07-03

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US (2) US10398768B2 (cg-RX-API-DMAC10.html)
EP (1) EP3212672A4 (cg-RX-API-DMAC10.html)
JP (1) JP6671364B2 (cg-RX-API-DMAC10.html)
KR (1) KR20170075775A (cg-RX-API-DMAC10.html)
CN (1) CN107207619A (cg-RX-API-DMAC10.html)
AU (1) AU2015338859A1 (cg-RX-API-DMAC10.html)
BR (1) BR112017008952A2 (cg-RX-API-DMAC10.html)
CA (1) CA2966198A1 (cg-RX-API-DMAC10.html)
MX (1) MX2017005524A (cg-RX-API-DMAC10.html)
MY (1) MY179251A (cg-RX-API-DMAC10.html)
SG (1) SG11201703366RA (cg-RX-API-DMAC10.html)
WO (1) WO2016070178A1 (cg-RX-API-DMAC10.html)

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Publication number Priority date Publication date Assignee Title
WO2018026845A1 (en) * 2016-08-01 2018-02-08 Inbios International, Inc. Immunoassay methods and compositions for detecting infection involving use of test antigens as cross-reactive control antigens
CN106632620B (zh) * 2016-11-29 2019-08-23 菲鹏生物股份有限公司 登革病毒重组抗原及其制备方法和应用
US11370830B2 (en) 2017-04-07 2022-06-28 The Rockefeller University Neutralizing antibodies that bind to the zika virus domain III envelope region
CN110568190A (zh) * 2019-08-30 2019-12-13 深圳国际旅行卫生保健中心 登革热病毒抗原、检测试剂、检测试纸、检测试剂盒及其使用方法
US12600752B2 (en) 2019-11-20 2026-04-14 The University Of North Carolina At Chapel Hill Methods and compositions for recombinant dengue viruses or vaccine and diagnostic development
WO2023178310A1 (en) * 2022-03-17 2023-09-21 The University Of North Carolina At Chapel Hill Compositions comprising modified flavivirus e glycoproteins and methods of making and using the same
CN116716322B (zh) * 2023-05-12 2024-05-31 中山大学 一种denv-3全长感染性克隆及其构建方法与应用
WO2024238948A2 (en) * 2023-05-17 2024-11-21 University Of Iowa Research Foundation Dengue virus serotype-specific modulation of t cell responses

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4501729A (en) 1982-12-13 1985-02-26 Research Corporation Aerosolized amiloride treatment of retained pulmonary secretions
CA1247080A (en) 1983-03-08 1988-12-20 Commonwealth Serum Laboratories Commission Antigenically active amino acid sequences
DE69313134T2 (de) 1992-06-25 1998-02-26 Smithkline Beecham Biolog Adjuvantien enthaltende impfstoffzusammensetzung
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
WO2003102166A2 (en) * 2002-02-26 2003-12-11 Maxygen, Inc. Novel flavivirus antigens
AU2005327198B2 (en) 2004-07-09 2011-03-31 University Of North Carolina At Chapel Hill Viral adjuvants
DK2054428T3 (da) * 2006-08-15 2013-08-26 Government Of The U S A As Repr By The Secretary Dept Of Health & Human Services The Nat Inst Of Hea Udvikling af bestanddele til denque-virus-vaccine
EP2834265A4 (en) * 2012-04-02 2015-10-14 Univ North Carolina METHOD AND COMPOSITIONS FOR DENGUE VIRUS EPITOPES
BR112015032388A8 (pt) * 2013-06-26 2020-01-14 Univ North Carolina Chapel Hill glicoproteína e do vírus quimérico da dengue, seus usos, partícula de flavivírus, molécula de ácido nucleico isolado, e composições

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US20200230224A1 (en) 2020-07-23
CA2966198A1 (en) 2016-05-06
MX2017005524A (es) 2018-01-26
MY179251A (en) 2020-11-02
AU2015338859A1 (en) 2017-06-01
SG11201703366RA (en) 2017-05-30
WO2016070178A1 (en) 2016-05-06
CN107207619A (zh) 2017-09-26
BR112017008952A2 (en) 2018-01-16
US20170333548A1 (en) 2017-11-23
EP3212672A4 (en) 2018-04-25
EP3212672A1 (en) 2017-09-06
US10398768B2 (en) 2019-09-03
JP6671364B2 (ja) 2020-03-25
JP2018500878A (ja) 2018-01-18

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