KR20170058901A - Composition of skin external application for skin homeostasis containing ginseng berry extracts - Google Patents

Abstract

The present invention relates to an external skin application composition, comprising a ginseng berry extract and, more specifically, to an external skin application composition having a skin homeostasis maintaining effect by inhibiting proliferation of harmful skin bacteria through containing the ginseng berry extract having a unique composition and a unique ingredient among a ginseng ground part, as an active ingredient.

Description

Technical Field [0001] The present invention relates to a composition for external application for skin homeostasis containing ginseng fruit extract,

The present invention relates to a composition for external application for skin containing ginseng fruit extract, and more particularly, to a composition for external application for skin containing ginseng fruit extract, which contains, as an active ingredient, ginseng fruit extract having a unique composition and composition from the above- And an excellent external preparation for skin.

Ginseng (Panax ginseng C.A. Meyer) is a herb that belongs to the genus Ogawa and Ginseng. It has been used in Korea, China and Japan for over 2,000 years and has been used empirically to prevent disease and prolong the life span. The efficacy and effect of ginseng which has been known so far can be determined by the action of the central nervous system, the anticarcinogenic action, the anticancer activity, the immune function regulating action, the anti-diabetic action, the hyperfunction of liver function, the improvement of cardiovascular disorder, (Korean Ginseng & Tobacco Research Institute, 56-112, 1996). In addition, it has been reported that the antioxidant activity and antioxidant activity of osteoporosis are improved.

Ginsenoside, which is a representative physiologically active ingredient of ginseng, is distributed evenly on the ground and underground of ginseng. Especially, ginsenoside (root), ginseng leaf and ginseng berries have not only ginsenoside content but also composition (Attele AS et al, Biochem Pharmacol, 58: 1685-1693, 1999). Recently, consumers are interested in natural cosmetics. At the same time, many cosmetics using herbal materials have been launched, and ginseng has been studied as a plant material having important skin effect of cosmetics. However, most of them are ginseng root extract or ginseng root ginsenoside Only side effects and ginseng polysaccharides are utilized, and there is no research on the efficacy of maintaining the skin homeostasis by the ingredients of ginseng fruit.

Accordingly, the inventors of the present invention found that the extract of ginseng fruit has an excellent skin homeostasis effect due to ingredients and compositions different from those of general ginseng and red ginseng, while searching for a natural substance capable of maintaining the homeostasis of the skin. It was completed.

Accordingly, it is an object of the present invention to provide a composition for external application for skin which is excellent in the effect of maintaining skin homeostasis by using a natural material safe for human body.

In order to achieve the above object, the present invention provides an external composition for skin homeostasis for skin homeostasis comprising an extract of ginseng fruit as an active ingredient.

In the present invention, ginseng root extract and ginseng extract having different composition and composition from ginseng root are included as an effective ingredient in the top part of ginseng to balance skin bacteria, lower skin temperature, increase blood flow and skin moisture content, A skin external composition composition could be provided.

FIG. 1 is a graph showing the skin temperature reduction effect of the ginseng fruit extract according to the present invention.
FIG. 2 is a graph showing the skin blood flow increasing effect of the ginseng fruit extract according to the present invention.
FIG. 3 is a graph showing the skin moisture content increasing effect of the ginseng fruit extract according to the present invention.

The present invention provides a composition for external application for skin, which contains a ginseng fruit extract as an active ingredient.

Hereinafter, the present invention will be described in more detail.

The ginseng fruit extract according to the present invention is prepared by extracting the flesh and the skin of ginseng fruit which have been separated from seeds by sunlight drying or hot air drying and extracting with water or ethanol.

The composition comprising the extract of fruit ginseng according to the present invention as an active ingredient has an inhibitory effect on skin-harmful bacteria and maintains the normal pH of the skin, thereby increasing the proliferation of normal skin fungus, And exhibits antimicrobial activity. In addition, it has an effect of maintaining the normal microorganism balance of the skin through selective antimicrobial activity that inhibits the proliferation of causative bacteria of skin diseases and increases the growth of microorganisms constituting a healthy skin environment.

In addition, the composition comprising the ginseng fruit extract of the present invention as an active ingredient is excellent in skin homeostasis maintenance effect by lowering skin temperature, increasing blood flow, and increasing skin moisture content.

The ginseng fruit extract of the present invention may be mixed in an amount of 0.0001 to 50% by weight based on the total weight of the composition, depending on the form of the composition for external application for skin. If the amount of the ginseng fruit extract is less than 0.0001% by weight, the effect is insignificant, while if it exceeds 50% by weight, the formulation stability is deteriorated.

The cosmetic form according to the invention contains a cosmetically or dermatologically acceptable medium or base. It may be in any form suitable for topical application, for example as a solution, a gel, a solid, a paste anhydrous product, an emulsion obtained by dispersing the oil phase in water, a suspension, a microemulsion, a microcapsule, a microgranule, In the form of a non-ionic follicle dispersing agent, or in the form of creams, skins, lotions, powders, ointments, sprays or conical sticks. These compositions may be prepared according to conventional methods in the art. The composition according to the invention may also be used in the form of a foam or in the form of an aerosol composition further containing a compressed propellant.

The cosmetic composition of the present invention can be used in the form of a cosmetic or dermatological composition comprising a lipid, an organic solvent, a solubilizing agent, a thickening agent, a gelling agent, a softening agent, an antioxidant, a suspending agent, a stabilizer, a foaming agent, a fragrance, , Cosmetics such as fillers, sequestering agents, chelating agents, preservatives, vitamins, blocking agents, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, lipid vesicles or any other ingredient commonly used in cosmetics May contain adjuvants conventionally used in the field of dermatology. Such adjuvants are introduced in amounts commonly used in the cosmetics or dermatological fields.

The external preparation for skin including the extract of fruit ginseng according to the present invention is not particularly limited in its formulation, and examples thereof include softening agents, convergent lotion, nutritional lotion, nutritional cream, massage cream, essence, eye cream, eye essence, Cream, cleansing foam, cleansing water, pack, powder, body lotion, body cream, body oil and body essence.

Hereinafter, the constitution and effects of the present invention will be described in more detail with reference to examples and test examples. However, these examples and examples are provided for illustrative purposes only in order to facilitate understanding of the present invention, and the scope and scope of the present invention are not limited by the following examples.

[Production Example 1] Preparation of ginseng fruit extract

1) Ginseng fruit pretreatment: The raw ginseng fruit was harvested and the seeds were separated and removed. Then, the ginseng fruit and the peel were dried in daylight or hot air to prepare ginseng fruit raw material.

2) Preparation of ginseng fruit extract: 1 kg of dried ginseng fruit was refluxed by adding 3 L of water, and then filtered and concentrated under reduced pressure at 40 to 45 ° C. to obtain 300 g of ginseng fruit extract.

[Production Example 2] Production of ginseng muscle root extract

In the same manner as in Preparation Example 1 except that ginseng roots (roots) were used instead of the ginseng fruit in Production Example 1 described above.

[Test Example 1] Comparison of components of ginseng fruit extract

<Analysis of Ginsenoside (Ginseng Saponin) Components of Ginseng Fruit and Ginseng Root>

The extracts of ginseng and ginseng roots were prepared in Preparation Examples 1 and 2, respectively. Then, the extracts were treated with ether to remove fat-soluble components, and then crude saponin was extracted and concentrated with butanol (BuOH) Side component analysis was carried out, and the results are shown in Table 1.

Production Example 1 Production Example 2 Crude saponin content
(Dry weight) 33.42% 16.70% PD / PT ratio 0.73 3.23

As can be seen from Table 1, the ginseng fruit extract prepared in Preparation Example 1 contained about twice the crude saponin content of the ginseng root extract prepared in Preparation Example 2, and the ginsenoside was classified into Protopanaxadiol (PD) - "Ginsenosides Rb1, Rb2, Rc and Rd" and PT (Protopanaxatriol) - "Ginsenoside Re, Rg1 and Rg2" were 0.73 and 3.23, respectively, Showed distinct differences and features.

<Mineral composition analysis of ginseng fruit extract>

In order to distinguish the ginseng fruit extract prepared in Preparation Example 1 from the ginseng, the minerals including vitamins were analyzed. The results are shown in Table 2 below.

ingredient content ingredient content Potassium (mg / 100g) 5865.57 Magnesium (mg / 100 g) 354.38 Calcium (mg / 100g) 819.26 Zinc (mg / 100g) 178.49 Iron (mg / 100g) 59.31 Vitamin A (㎍ / 100 g, RE) 213.11 Phosphorus (mg / 100 g) 187.17 Vitamin B1 (mg / 100g) 12.29 Vitamin B2 (mg / 100g) 8.45 Vitamin B6 (mg / 100g) 10.50 Vitamin C (mg / 100g) 4.91 Vitamin E (mg / 100 g, a-TE) 23.61 Vitamin K (㎍ / 100g) 232.12 Niacin (mg / 100 g, NE) 5.76 Pantothenic acid (mg / 100g) 5.87 Folate (㎍ / 100g) 349.97

As described above, the constituent characteristics of the ginseng fruit used in the present invention is that the ginseng saponin is contained in a larger amount than that of the ginseng root, and the saponin composition properties are opposite to each other. Also, unlike the ginseng root, the content of 16 kinds of vitamins and minerals is rich , And based on this, the following experiments on skin efficacy were conducted.

[Test Example 2] Evaluation of antibacterial effect using a broth dilution method

In order to evaluate the antimicrobial effect of the present invention, P. acnes ATCC 6919 and S. epidermidis ATCC 12228 were used as test strains. Peptone 1% aqueous solution was added with the two samples prepared in the above Preparation Example and sterilized. The test bacteria were inoculated and cultured for 24 hours. In the case of P. acnes ATCC 6919, anaerobically cultured. The incubated solution was then diluted. S. epidermidis ATCC 12228 diluted solution was plated on TS agar surface and cultured for 24 hours. Bacterial dilution of P. acnes ATCC 6919 was applied to BHI agar and incubated for 3 days. The control group was the result of measuring the number of bacteria in the diluted solution in which only the test strain was cultured without adding the sample. The measurement results are shown in Table 3.

Sample name Measured number of bacteria (cfu / ml) S. epidermidis ATCC 12228 P. acnes ATCC 6919 Ginseng fruit extract (Preparation Example 1) 1% 3 x 10 ⁹ <10 ⁵ Ginseng root extract (Preparation Example 2) 1% 1.02 x 10 ⁹ 1 x 10 ⁵ Control group 4.0 x 10 ⁸ 3.6 x 10 ⁷

* The minimum detection limit for bacteria is <10 ⁵ .

As shown in Table 3, all the test samples exhibited an inhibitory effect on P. acnes and a proliferative effect on S. epidermidis. However, in the case of using the extract of the ginseng fruit of the present invention, P. acnes The proliferation inhibitory effect and the proliferative effect of S. epidermidis on the skin were higher or similar to those of the control group.

[Experimental Example 3] Experiment on improvement of skin homeostasis

Examples of the cosmetic formulation containing the ginseng fruit extract obtained in Preparation Example 1 were prepared according to the composition shown in Table 4 below.

Compounding ingredient Example
Content (% by weight) Purified water Balance Ginseng fruit extract (Preparation Example 1) 0.1 Vegetable hydrogenated oil 1.5 Stearic acid 0.6 Polyglycerol-10 penta stearic / behenyl alcohol / sodium stearoyl lactylate
It 1.0 Arachidyl behenyl alcohol / arachidyl glucoside 1.0 Cetylaryl alcohol / cetearyl glucoside 2.0 PEG-100 stearate / glycerol oleate / propylene glycol 1.5 Caprylic / Carrick Triglyceride 4.0 Meadow Foam Berry Oil 3.0 Cetyl octanoate 4.0 Cyclomethicone 6.0 Methyl paraben 0.2 Propylparaben 0.1 Disodium EDTA 0.02 Triethanolamine 0.13 glycerin 8.0 Carbomer 0.13

Ten women in their 40s and 50s who needed skin improvement were allowed to use the lotion of the example twice daily for 30 days. The skin temperature, blood flow, and water content were measured after washing using a cleansing bar, followed by constant temperature and humidity (24 ° C, 40% humidity) for 15 minutes. For comparison, the condition before use of the lotion was measured in advance, and the condition of the skin was measured at 10 days, 21 days, and 30 days after use.

Skin temperature was measured using the IR camera (ThermaCAM TM PM575, FLIR System TM, Sweden) on the forehead, the left cheek, the right cheek and the jaw. Skin blood flow was measured using the LDI Periscan PIMII (Perimed AB, Sweden) Jaw area was measured. Skin moisture was measured using the Corneometer CM825 (C + K, Germany) on the forehead, left cheek, right cheek, and chin.

At the end of the test, subjects were asked to fill out questionnaires and perform subjective evaluation of efficacy at the same time.

As a result of measuring the skin temperature, the skin temperature on the forehead, cheeks and chin gradually decreased as shown in FIG. In the case of women aged 40-50, there are many opportunities to be exposed to ultraviolet rays due to the large amount of activity during the daytime, and there are many cases in which menopausal symptoms are caused by the imbalance of hormones caused by menopausal age, Of the skin temperature is high. Therefore, the skin temperature lowering effect of the ginseng fruit extract can help maintain the homeostasis of the skin.

As a result of skin blood flow measurement, the blood flow in the cheeks and jaws gradually increased as seen in FIG. This indicates that the blood circulation for promoting the maintenance of skin homeostasis is promoted by the ginseng fruit extract. In the case of women aged 40-50, there are many cases where the blood circulation is reduced from the viewpoint of Oriental medicine and the blood collects. This hemolysis may cause a disproportion of the nutritional supply of the skin, which may be a main cause of breaking the homeostasis of the skin. Therefore, the blood flow increase effect of the ginseng fruit extract can help maintain the skin homeostasis by keeping the nutrition supply of the skin smooth.

As a result of skin moisture measurement, the moisture content of the skin on the forehead, cheeks and chin gradually increased as shown in Fig. This indicates that the water content of the skin for maintaining the skin homeostasis is increased by the extract of the ginseng fruit.

 [Formulation Example 1] Nutritional lotion (milk lotion)

Compounding ingredient Content (% by weight) Purified water Balance Ginseng fruit extract 0.1 Wax 4.0 Polysorbate 60 1.5 Sorbitan sesquioleate 1.5 Liquid paraffin 0.5 Montana 202 (Manufacturer: Seppic) 5.0 glycerin 3.0 Butylene glycol 3.0 Propylene glycol 3.0 Carboxyvinyl polymer 0.1 Triethanolamine 0.2 Preservative, coloring, fragrance Suitable amount

[Formulation Example 2] Massage cream

Compounding ingredient Content (% by weight) Purified water Balance Ginseng fruit extract 0.1 Wax 10.0 Polysorbate 60 1.5 Piggy 60 hardened castor oil 2.0 Sorbitan sesquioleate 0.8 Liquid paraffin 40.0 Squalane 5.0 Montana 202 (Manufacturer: Seppic) 4.0 glycerin 5.0 Butylene glycol 3.0 Propylene glycol 3.0 Triethanolamine 0.2 Preservative, coloring, fragrance Suitable amount

[Formulation Example 3] Pack

Compounding ingredient Content (% by weight) Purified water Balance Ginseng fruit extract 0.1 Polyvinyl alcohol 13.0 Sodium carboxymethylcellulose 0.2 glycerin 5.0 Allantoin 0.1 ethanol 6.0 Pingyi-12 nonylphenyl ether 0.3 Polysorbate 60 0.3 Preservative, coloring, fragrance Suitable amount

Claims (2)

A composition for external application for skin for maintaining homeostasis of skin, which contains ginseng fruit extract as an active ingredient. The composition for external application for skin homeostasis according to claim 1, wherein the ginseng fruit extract is contained in an amount of 0.0001 to 50% by weight based on the total weight of the composition.

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