KR20170043509A - 헵시딘 및 미니-헵시딘 유사체 및 그의 용도 - Google Patents
헵시딘 및 미니-헵시딘 유사체 및 그의 용도 Download PDFInfo
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- KR20170043509A KR20170043509A KR1020177002630A KR20177002630A KR20170043509A KR 20170043509 A KR20170043509 A KR 20170043509A KR 1020177002630 A KR1020177002630 A KR 1020177002630A KR 20177002630 A KR20177002630 A KR 20177002630A KR 20170043509 A KR20170043509 A KR 20170043509A
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- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
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- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462018382P | 2014-06-27 | 2014-06-27 | |
| US62/018,382 | 2014-06-27 | ||
| PCT/US2015/038370 WO2015200916A2 (en) | 2014-06-27 | 2015-06-29 | Hepcidin and mini-hepcidin analogues and uses therof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20170043509A true KR20170043509A (ko) | 2017-04-21 |
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|---|---|
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| EP (1) | EP3161164A4 (enExample) |
| JP (1) | JP2017523959A (enExample) |
| KR (1) | KR20170043509A (enExample) |
| CN (1) | CN107075574A (enExample) |
| AU (1) | AU2015279571A1 (enExample) |
| CA (1) | CA2953721A1 (enExample) |
| IL (1) | IL249692A0 (enExample) |
| SG (1) | SG11201610799WA (enExample) |
| WO (1) | WO2015200916A2 (enExample) |
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| EP2186524B1 (en) | 2001-05-25 | 2018-02-21 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of hepcidin for preparing a medicament for treating disorders of iron homeostasis |
| EP4091624A1 (en) | 2013-03-15 | 2022-11-23 | Protagonist Therapeutics, Inc. | Hepcidin analogues and uses thereof |
| US12383518B2 (en) | 2013-11-03 | 2025-08-12 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Disulfide-masked pro-chelator compositions and methods of use |
| WO2019018377A1 (en) * | 2017-07-18 | 2019-01-24 | Arizona Board Of Regents On Behalf Of The University Of Arizona | DISULFIDE-MASKED PRO-CHELATE COMPOSITIONS AND METHODS OF USE |
| US11504346B2 (en) | 2013-11-03 | 2022-11-22 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Redox-activated pro-chelators |
| CA2949215C (en) | 2014-05-16 | 2023-03-14 | Protagonist Therapeutics, Inc. | .alpha.4.beta.7 integrin thioether peptide antagonists |
| SG10201810154WA (en) | 2014-07-17 | 2018-12-28 | Protagonist Therapeutics Inc | Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases |
| JP2017535527A (ja) | 2014-10-01 | 2017-11-30 | プロタゴニスト セラピューティクス， インコーポレイテッド | 新規のα４β７ペプチド単量体及び二量体拮抗薬 |
| WO2016054445A1 (en) | 2014-10-01 | 2016-04-07 | Protagonist Therapeutics, Inc. | Novel cyclic monomer and dimer peptides having integrin antagonist activity |
| US10787490B2 (en) | 2015-07-15 | 2020-09-29 | Protaganist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| CA3009834A1 (en) | 2015-12-30 | 2017-07-06 | Protagonist Therapeutics, Inc. | Analogues of hepcidin mimetics with improved in vivo half lives |
| EP3399996A4 (en) * | 2016-01-08 | 2019-10-16 | La Jolla Pharmaceutical Company | METHOD FOR THE ADMINISTRATION OF HEPCIDINE |
| CA3017926C (en) | 2016-03-23 | 2023-10-10 | Protagonist Therapeutics, Inc. | Methods for synthesizing .alpha.4.beta.7 peptide antagonists |
| WO2018022937A1 (en) | 2016-07-27 | 2018-02-01 | Protagonist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 and their use to treat inflammatory diseases |
| AU2017324446A1 (en) * | 2016-09-06 | 2019-03-28 | La Jolla Pharmceutical Company | Methods of treating iron overload |
| CA3047320A1 (en) * | 2016-12-19 | 2018-06-28 | La Jolla Pharmaceutical Company | Methods of administering hepcidin |
| WO2018128828A1 (en) | 2016-12-23 | 2018-07-12 | Bayer Healthcare Llc | Novel hepcidin mimetics and uses thereof |
| EP3681900A4 (en) | 2017-09-11 | 2021-09-08 | Protagonist Therapeutics, Inc. | OPIOID AGONIST PEPTIDES AND THEIR USES |
| WO2019157268A1 (en) * | 2018-02-08 | 2019-08-15 | Protagonist Therapeutics, Inc. | Conjugated hepcidin mimetics |
| CA3104418A1 (en) | 2018-07-12 | 2020-01-16 | Protagonist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| ES2934492T3 (es) | 2018-12-13 | 2023-02-22 | Global Blood Therapeutics Inc | Inhibidores de ferroportina y métodos de uso |
| CA3139209A1 (en) | 2019-05-07 | 2020-11-12 | Bayer Aktiengesellschaft | Masp inhibitory compounds and uses thereof |
| AU2020311395A1 (en) | 2019-07-10 | 2022-02-03 | Protagonist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| US20220372099A1 (en) | 2019-09-03 | 2022-11-24 | Protagonist Therapeutics, Inc. | Conjugated hepcidin mimetics |
| CA3156007A1 (en) * | 2019-09-27 | 2021-04-01 | Disc Medicine, Inc. | METHODS OF TREATING MYELOFIBROSE AND ASSOCIATED CONDITIONS |
| US20220372136A1 (en) * | 2019-09-27 | 2022-11-24 | Disc Medicine, Inc. | Methods for treating anemia of chronic disease |
| MX2022008740A (es) | 2020-01-15 | 2022-09-23 | Janssen Biotech Inc | Peptidos inhibidores del receptor de interleucina-23 y su uso para tratar enfermedades inflamatorias. |
| SMT202500254T1 (it) | 2020-01-15 | 2025-09-12 | Janssen Biotech Inc | Inibitori peptidici del recettore dell'interleuchina-23 e loro uso per trattare malattie infiammatorie |
| CA3181577A1 (en) | 2020-04-28 | 2021-11-04 | Global Blood Therapeutics, Inc. | Thieno pyrimidines as ferroportin inhibitors |
| CA3181583A1 (en) | 2020-04-28 | 2021-11-04 | Global Blood Therapeutics, Inc. | Methods of use for pyrimidines as ferroportin inhibitors |
| US11746100B2 (en) | 2020-04-28 | 2023-09-05 | Global Blood Therapeutics, Inc. | Cycloalkyl pyrimidines as ferroportin inhibitors |
| ES3075793T3 (en) | 2020-05-13 | 2026-08-07 | Disc Medicine Inc | Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis |
| AU2021273014A1 (en) | 2020-05-13 | 2022-11-17 | AbbVie Deutschland GmbH & Co. KG | Anti-hemojuvelin (HJV) antibodies for treating anemia of chronic disease |
| CN111560051B (zh) * | 2020-05-26 | 2022-11-25 | 大连工业大学 | 一种具有促铁吸收活性的虾源九肽及其应用 |
| KR20230035082A (ko) * | 2020-07-02 | 2023-03-10 | 탐페레 유니버시티 파운데이션 에스알 | 헵시딘의 레닌-기반 분석 |
| IL299530A (en) * | 2020-07-28 | 2023-02-01 | Protagonist Therapeutics Inc | Psidine is a conjugated mimetic |
| CN114252627A (zh) * | 2020-09-24 | 2022-03-29 | 首都医科大学附属北京世纪坛医院 | 尿液铁调素及其多肽片段在过敏性疾病中的应用 |
| AU2021383828A1 (en) | 2020-11-20 | 2023-07-06 | Janssen Pharmaceutica Nv | Compositions of peptide inhibitors of interleukin-23 receptor |
| WO2022212696A1 (en) * | 2021-04-01 | 2022-10-06 | Protagonist Therapeutics, Inc. | Conjugated hepcidin mimetics |
| CA3220871A1 (en) * | 2021-06-14 | 2022-12-22 | Protagonist Therapeutics, Inc. | Hepcidin mimetics for treatment of hereditary hemochromatosis |
| KR20240034224A (ko) | 2021-07-14 | 2024-03-13 | 얀센 바이오테크 인코포레이티드 | 인터류킨-23 수용체의 지질화된 펩티드 억제제 |
| CN115703826B (zh) * | 2021-08-03 | 2025-05-06 | 浙江大学 | 铁调素改造体及其应用 |
| EP4536683A4 (en) * | 2022-06-07 | 2026-06-10 | Protagonist Therapeutics Inc | HEPCIDINE MIMETIC AGENTS FOR THE TREATMENT OF SICKLE CELL DISEASE |
| US20260224514A1 (en) * | 2022-09-15 | 2026-08-06 | Migal Galilee Research Institute Ltd. | Site-specific activation of regulatory t cells |
| WO2025224128A1 (en) | 2024-04-24 | 2025-10-30 | Institut National de la Santé et de la Recherche Médicale | Methods of treatment of iron overload associated diseases by administration hepcidin locally in the gut |
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| PE20130588A1 (es) * | 2007-02-02 | 2013-05-21 | Amgen Inc | Hepcidina, antagonistas de la hepcidina y metodos de uso |
| CN101358201A (zh) * | 2007-07-31 | 2009-02-04 | 钱忠明 | 重组人铁调素腺病毒、其制备方法及应用 |
| CN101307085B (zh) * | 2007-08-01 | 2012-06-13 | 香港理工大学深圳研究院 | 抑制铁调素调节蛋白的siRNA、重组慢病毒及其应用 |
| GR1006896B (el) * | 2007-08-24 | 2010-07-20 | Ελληνικο Ινστιτουτο Παστερ, | Μεθοδος παραγωγης μιας πεπτιδικης ορμονης |
| WO2010065815A2 (en) * | 2008-12-05 | 2010-06-10 | The Regents Of The University Of California | Mini-hepcidin peptides and methods of using thereof |
| US20130236977A1 (en) * | 2010-05-24 | 2013-09-12 | Children's Medical Center Corporation | Compositions and methods for plasma peptide analysis |
| BR112014013697A2 (pt) * | 2011-12-09 | 2020-11-03 | The Regents Of The University Of California | peptídeos mini-hepcidina modificados e métodos de uso dos mesmos |
| EP4091624A1 (en) * | 2013-03-15 | 2022-11-23 | Protagonist Therapeutics, Inc. | Hepcidin analogues and uses thereof |
-
2015
- 2015-06-29 AU AU2015279571A patent/AU2015279571A1/en not_active Abandoned
- 2015-06-29 US US15/321,124 patent/US20170313754A1/en not_active Abandoned
- 2015-06-29 CA CA2953721A patent/CA2953721A1/en not_active Abandoned
- 2015-06-29 CN CN201580043057.2A patent/CN107075574A/zh active Pending
- 2015-06-29 EP EP15812513.8A patent/EP3161164A4/en not_active Withdrawn
- 2015-06-29 SG SG11201610799WA patent/SG11201610799WA/en unknown
- 2015-06-29 KR KR1020177002630A patent/KR20170043509A/ko not_active Withdrawn
- 2015-06-29 JP JP2016575360A patent/JP2017523959A/ja not_active Withdrawn
- 2015-06-29 WO PCT/US2015/038370 patent/WO2015200916A2/en not_active Ceased
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2016
- 2016-12-21 IL IL249692A patent/IL249692A0/en unknown
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2019
- 2019-06-12 US US16/439,435 patent/US20200017566A1/en not_active Abandoned
Also Published As
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| SG11201610799WA (en) | 2017-01-27 |
| US20200017566A1 (en) | 2020-01-16 |
| IL249692A0 (en) | 2017-02-28 |
| CA2953721A1 (en) | 2015-12-30 |
| WO2015200916A2 (en) | 2015-12-30 |
| EP3161164A2 (en) | 2017-05-03 |
| EP3161164A4 (en) | 2018-04-25 |
| US20170313754A1 (en) | 2017-11-02 |
| AU2015279571A1 (en) | 2017-02-02 |
| CN107075574A (zh) | 2017-08-18 |
| JP2017523959A (ja) | 2017-08-24 |
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