KR20170042373A - 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템 - Google Patents

영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템 Download PDF

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KR20170042373A
KR20170042373A KR1020177009313A KR20177009313A KR20170042373A KR 20170042373 A KR20170042373 A KR 20170042373A KR 1020177009313 A KR1020177009313 A KR 1020177009313A KR 20177009313 A KR20177009313 A KR 20177009313A KR 20170042373 A KR20170042373 A KR 20170042373A
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imaging agent
salt
imaging
formula
compound
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Korean (ko)
Inventor
아자이 푸로히트
페드로 베니테스
에드워드 에이치. 치스먼
조엘 레이즈왓스키
버라니커 리
리처드 알. 3세 세사티
리처드 루비
하이케 에스. 라데케
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랜티우스 메디컬 이메징, 인크.
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/30—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reactions not involving the formation of esterified sulfo groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
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    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
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    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
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    • C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
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    • C07C279/10—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by doubly-bound oxygen atoms
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    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
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    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
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    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
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    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
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    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
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    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
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KR1020177009313A 2010-05-11 2011-05-11 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템 Ceased KR20170042373A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US33361810P 2010-05-11 2010-05-11
US61/333,618 2010-05-11
US40557110P 2010-10-21 2010-10-21
US40552410P 2010-10-21 2010-10-21
US61/405,571 2010-10-21
US61/405,524 2010-10-21
PCT/US2011/036142 WO2011143360A2 (en) 2010-05-11 2011-05-11 Compositions, methods and systems for the synthesis and use of imaging agents

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KR1020177009313A Ceased KR20170042373A (ko) 2010-05-11 2011-05-11 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템
KR1020127032221A Expired - Fee Related KR101726471B1 (ko) 2010-05-11 2011-05-11 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템
KR1020197022611A Expired - Fee Related KR102136503B1 (ko) 2010-05-11 2011-05-11 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템
KR1020187015363A Expired - Fee Related KR102008635B1 (ko) 2010-05-11 2011-05-11 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템

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KR1020197022611A Expired - Fee Related KR102136503B1 (ko) 2010-05-11 2011-05-11 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템
KR1020187015363A Expired - Fee Related KR102008635B1 (ko) 2010-05-11 2011-05-11 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템

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US (5) US9388125B2 (enExample)
EP (2) EP3653230B1 (enExample)
JP (2) JP5992399B2 (enExample)
KR (4) KR20170042373A (enExample)
CN (2) CN103002924A (enExample)
AU (1) AU2011253052B2 (enExample)
BR (4) BR122020018186B1 (enExample)
CA (2) CA2798488C (enExample)
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EP3323810B1 (en) 2010-02-08 2022-01-05 Lantheus Medical Imaging, Inc. Automated reaction system, cassette and apparatus for synthesizing imaging agents
BR122020018186B1 (pt) * 2010-05-11 2021-07-27 Lantheus Medical Imaging, Inc Uso de agentes de imagiologia para preparação de uma composição para detecção do transportador de norepinefrina (net) e método para a detecção de net
BR122019017259B1 (pt) 2011-09-09 2022-05-10 Lantheus Medical Imaging, Inc Compostos úteis como agentes de imageamento, composições que os compreende, métodos, e uso de agentes de imageamento
WO2013070471A1 (en) 2011-11-11 2013-05-16 Lantheus Medical Imaging, Inc. Evaluation of presence of and vulnerability to atrial fibrillation and other indications using matrix metalloproteinase-based imaging
PT2836241T (pt) 2012-04-10 2019-05-30 Lantheus Medical Imaging Inc Métodos de síntese de radiofármacos
AU2013203000B9 (en) * 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
US20150246142A1 (en) 2012-09-25 2015-09-03 The Regents Of The University Of Michigan Imaging agents
CN107106710A (zh) * 2014-10-24 2017-08-29 分子制药洞察公司 间‑碘苄基胍及其前体的制剂
WO2016138448A1 (en) * 2015-02-27 2016-09-01 Schmitthenner Hans F Transmetalation methods for the synthesis of pet and spect imaging agents
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WO2017053834A1 (en) * 2015-09-25 2017-03-30 Board Of Regents Of The University Of Nebraska Mibg analogs and uses thereof
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