KR20170036727A - 혼성화를 이용한 표적 핵산 검출 방법 - Google Patents

혼성화를 이용한 표적 핵산 검출 방법 Download PDF

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Publication number
KR20170036727A
KR20170036727A KR1020177004719A KR20177004719A KR20170036727A KR 20170036727 A KR20170036727 A KR 20170036727A KR 1020177004719 A KR1020177004719 A KR 1020177004719A KR 20177004719 A KR20177004719 A KR 20177004719A KR 20170036727 A KR20170036727 A KR 20170036727A
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South Korea
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region
oligonucleotides
regions
sequence
oligonucleotide
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KR1020177004719A
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English (en)
Korean (ko)
Inventor
아놀드 올리팬트
제이콥 잔
카라 쥬노
패트릭 보가드
스테파니 황
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아리오사 다이어그노스틱스, 아이엔씨.
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Priority claimed from US14/450,144 external-priority patent/US20140342940A1/en
Application filed by 아리오사 다이어그노스틱스, 아이엔씨. filed Critical 아리오사 다이어그노스틱스, 아이엔씨.
Publication of KR20170036727A publication Critical patent/KR20170036727A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6862—Ligase chain reaction [LCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/16—Assays for determining copy number or wherein the copy number is of special importance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/50—Detection characterised by immobilisation to a surface
    • C12Q2565/519—Detection characterised by immobilisation to a surface characterised by the capture moiety being a single stranded oligonucleotide

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020177004719A 2014-08-01 2015-07-29 혼성화를 이용한 표적 핵산 검출 방법 Ceased KR20170036727A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US14/450,144 2014-08-01
US14/450,144 US20140342940A1 (en) 2011-01-25 2014-08-01 Detection of Target Nucleic Acids using Hybridization
US14/453,396 2014-08-06
US14/453,396 US9567639B2 (en) 2010-08-06 2014-08-06 Detection of target nucleic acids using hybridization
PCT/US2015/042604 WO2016018986A1 (en) 2014-08-01 2015-07-29 Detection of target nucleic acids using hybridization

Publications (1)

Publication Number Publication Date
KR20170036727A true KR20170036727A (ko) 2017-04-03

Family

ID=55218263

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020177004719A Ceased KR20170036727A (ko) 2014-08-01 2015-07-29 혼성화를 이용한 표적 핵산 검출 방법

Country Status (10)

Country Link
EP (1) EP3175236B1 (cg-RX-API-DMAC10.html)
JP (1) JP6793112B2 (cg-RX-API-DMAC10.html)
KR (1) KR20170036727A (cg-RX-API-DMAC10.html)
CN (1) CN106537142B (cg-RX-API-DMAC10.html)
AU (1) AU2015296602B2 (cg-RX-API-DMAC10.html)
CA (1) CA2955740A1 (cg-RX-API-DMAC10.html)
ES (1) ES2752237T3 (cg-RX-API-DMAC10.html)
MX (1) MX376755B (cg-RX-API-DMAC10.html)
SG (1) SG11201700765WA (cg-RX-API-DMAC10.html)
WO (1) WO2016018986A1 (cg-RX-API-DMAC10.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026071688A1 (ko) * 2024-09-26 2026-04-02 주식회사 씨젠 경쟁적 혼성화물 기반 시그널링 어세이에 의한 타겟 핵산의 검출

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11203786B2 (en) 2010-08-06 2021-12-21 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US20140342940A1 (en) 2011-01-25 2014-11-20 Ariosa Diagnostics, Inc. Detection of Target Nucleic Acids using Hybridization
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
US20130261003A1 (en) 2010-08-06 2013-10-03 Ariosa Diagnostics, In. Ligation-based detection of genetic variants
US10533223B2 (en) 2010-08-06 2020-01-14 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US20130040375A1 (en) 2011-08-08 2013-02-14 Tandem Diagnotics, Inc. Assay systems for genetic analysis
US8700338B2 (en) 2011-01-25 2014-04-15 Ariosa Diagnosis, Inc. Risk calculation for evaluation of fetal aneuploidy
US10829816B2 (en) 2012-11-19 2020-11-10 Apton Biosystems, Inc. Methods of analyte detection
CN105659091A (zh) 2013-08-19 2016-06-08 卓异生物公司 用于单分子检测的测定及其应用
WO2016134191A1 (en) 2015-02-18 2016-08-25 Singular Bio, Inc. Assays for single molecule detection and use thereof
EP3601599A4 (en) * 2017-03-23 2020-12-23 Apton Biosystems, Inc. POLYMORPHISM DETECTION WITH INCREASED ACCURACY
WO2018223055A1 (en) * 2017-06-02 2018-12-06 Affymetrix, Inc. Array-based methods for analysing mixed samples using differently labelled allele-specific probes
WO2018223057A1 (en) * 2017-06-02 2018-12-06 Affymetrix, Inc. Array-based methods for analysing mixed samples using different allele-specific labels, in particular for detection of fetal aneuploidies
US11441174B2 (en) 2017-06-02 2022-09-13 Affymetrix, Inc. Array-based methods for analysing mixed samples using differently labelled allele-specific probes
WO2020076474A1 (en) * 2018-10-12 2020-04-16 Nantomics, Llc Prenatal purity assessments using bambam

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
US6506594B1 (en) * 1999-03-19 2003-01-14 Cornell Res Foundation Inc Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US20020042681A1 (en) * 2000-10-03 2002-04-11 International Business Machines Corporation Characterization of phenotypes by gene expression patterns and classification of samples based thereon
EP1685380A2 (en) * 2003-09-18 2006-08-02 Parallele Bioscience, Inc. System and methods for enhancing signal-to-noise ratios of microarray-based measurements
EP1689884A4 (en) * 2003-10-08 2007-04-04 Univ Boston PROCESS FOR THE PRENATAL DIAGNOSIS OF CHROMOSOMAL ABNORMALITIES
EP2024509A4 (en) * 2006-05-22 2010-08-04 Clinical Genomics Pty Ltd DETECTION METHOD
US20110159499A1 (en) * 2009-11-25 2011-06-30 Quantalife, Inc. Methods and compositions for detecting genetic material
CA2780016C (en) * 2009-11-06 2017-09-19 The Chinese University Of Hong Kong Size-based genomic analysis
US20120034603A1 (en) * 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
US10131947B2 (en) * 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
JP6153874B2 (ja) * 2011-02-09 2017-06-28 ナテラ， インコーポレイテッド 非侵襲的出生前倍数性呼び出しのための方法
AU2012281242B2 (en) * 2011-07-08 2016-12-22 Keygene N.V. Sequence based genotyping based on oligonucleotide ligation assays
US10196681B2 (en) * 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CN104204228A (zh) * 2012-02-14 2014-12-10 康奈尔大学 使用组合的核酸酶、连接和聚合酶反应用于核酸序列的相对定量、表达或拷贝变化的方法
WO2013192292A1 (en) * 2012-06-21 2013-12-27 Justin Lamb Massively-parallel multiplex locus-specific nucleic acid sequence analysis
CN104583421A (zh) * 2012-07-19 2015-04-29 阿瑞奥萨诊断公司 遗传变体的基于多重的顺序连接的检测

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026071688A1 (ko) * 2024-09-26 2026-04-02 주식회사 씨젠 경쟁적 혼성화물 기반 시그널링 어세이에 의한 타겟 핵산의 검출

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Publication number Publication date
CA2955740A1 (en) 2016-02-04
JP2017526347A (ja) 2017-09-14
CN106537142A (zh) 2017-03-22
SG11201700765WA (en) 2017-02-27
EP3175236A4 (en) 2017-12-27
MX376755B (es) 2025-03-07
MX2017001405A (es) 2017-05-17
AU2015296602A1 (en) 2017-02-16
EP3175236B1 (en) 2019-08-21
AU2015296602B2 (en) 2021-09-16
CN106537142B (zh) 2019-11-19
WO2016018986A1 (en) 2016-02-04
JP6793112B2 (ja) 2020-12-02
ES2752237T3 (es) 2020-04-03
EP3175236A1 (en) 2017-06-07

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