KR20160105822A - 트랜스-척추 직류 조절 시스템 - Google Patents
트랜스-척추 직류 조절 시스템 Download PDFInfo
- Publication number
- KR20160105822A KR20160105822A KR1020167020164A KR20167020164A KR20160105822A KR 20160105822 A KR20160105822 A KR 20160105822A KR 1020167020164 A KR1020167020164 A KR 1020167020164A KR 20167020164 A KR20167020164 A KR 20167020164A KR 20160105822 A KR20160105822 A KR 20160105822A
- Authority
- KR
- South Korea
- Prior art keywords
- nerve
- electrode
- stimulation
- electrodes
- stimulus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000000638 stimulation Effects 0.000 claims abstract description 216
- 230000001537 neural effect Effects 0.000 claims abstract description 62
- 239000012636 effector Substances 0.000 claims abstract description 57
- 210000000278 spinal cord Anatomy 0.000 claims abstract description 48
- 230000006870 function Effects 0.000 claims abstract description 40
- 210000000056 organ Anatomy 0.000 claims abstract description 40
- 230000007383 nerve stimulation Effects 0.000 claims abstract description 37
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims abstract description 9
- 210000005036 nerve Anatomy 0.000 claims description 285
- 238000000034 method Methods 0.000 claims description 224
- 210000003205 muscle Anatomy 0.000 claims description 76
- 230000002889 sympathetic effect Effects 0.000 claims description 44
- 230000001276 controlling effect Effects 0.000 claims description 40
- 210000005070 sphincter Anatomy 0.000 claims description 40
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 39
- 230000000694 effects Effects 0.000 claims description 38
- 238000011282 treatment Methods 0.000 claims description 33
- 210000003734 kidney Anatomy 0.000 claims description 27
- 210000005037 parasympathetic nerve Anatomy 0.000 claims description 25
- 230000002093 peripheral effect Effects 0.000 claims description 24
- 230000033228 biological regulation Effects 0.000 claims description 23
- 208000035475 disorder Diseases 0.000 claims description 23
- 210000003403 autonomic nervous system Anatomy 0.000 claims description 20
- 230000001105 regulatory effect Effects 0.000 claims description 18
- 208000003098 Ganglion Cysts Diseases 0.000 claims description 14
- 208000005400 Synovial Cyst Diseases 0.000 claims description 14
- 230000004936 stimulating effect Effects 0.000 claims description 14
- 210000001186 vagus nerve Anatomy 0.000 claims description 12
- 230000003187 abdominal effect Effects 0.000 claims description 11
- 208000014094 Dystonic disease Diseases 0.000 claims description 10
- 206010046543 Urinary incontinence Diseases 0.000 claims description 10
- 230000003767 neural control Effects 0.000 claims description 10
- 210000000813 small intestine Anatomy 0.000 claims description 10
- 208000011580 syndromic disease Diseases 0.000 claims description 10
- 208000010515 dystocia Diseases 0.000 claims description 9
- 208000010118 dystonia Diseases 0.000 claims description 9
- 230000003907 kidney function Effects 0.000 claims description 9
- 201000006549 dyspepsia Diseases 0.000 claims description 8
- 230000007661 gastrointestinal function Effects 0.000 claims description 8
- 210000002784 stomach Anatomy 0.000 claims description 8
- 230000001684 chronic effect Effects 0.000 claims description 7
- 210000000133 brain stem Anatomy 0.000 claims description 6
- 230000007433 nerve pathway Effects 0.000 claims description 6
- 206010007559 Cardiac failure congestive Diseases 0.000 claims description 5
- 208000034347 Faecal incontinence Diseases 0.000 claims description 5
- 206010019280 Heart failures Diseases 0.000 claims description 5
- 210000003195 fascia Anatomy 0.000 claims description 5
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 5
- 210000004392 genitalia Anatomy 0.000 claims description 5
- 230000001404 mediated effect Effects 0.000 claims description 5
- 210000003625 skull Anatomy 0.000 claims description 5
- 210000000273 spinal nerve root Anatomy 0.000 claims description 5
- 210000000331 sympathetic ganglia Anatomy 0.000 claims description 5
- 208000008589 Obesity Diseases 0.000 claims description 4
- 208000002193 Pain Diseases 0.000 claims description 4
- 208000005793 Restless legs syndrome Diseases 0.000 claims description 4
- 210000001072 colon Anatomy 0.000 claims description 4
- 210000001363 mesenteric artery superior Anatomy 0.000 claims description 4
- 235000020824 obesity Nutrition 0.000 claims description 4
- 210000000664 rectum Anatomy 0.000 claims description 4
- 210000005250 spinal neuron Anatomy 0.000 claims description 4
- 206010010774 Constipation Diseases 0.000 claims description 3
- 208000018522 Gastrointestinal disease Diseases 0.000 claims description 3
- 206010020772 Hypertension Diseases 0.000 claims description 3
- 210000003238 esophagus Anatomy 0.000 claims description 3
- 230000002757 inflammatory effect Effects 0.000 claims description 3
- 230000000977 initiatory effect Effects 0.000 claims description 3
- 230000035900 sweating Effects 0.000 claims description 3
- 210000005239 tubule Anatomy 0.000 claims description 3
- 206010000060 Abdominal distension Diseases 0.000 claims description 2
- 206010000087 Abdominal pain upper Diseases 0.000 claims description 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 2
- 206010010539 Congenital megacolon Diseases 0.000 claims description 2
- 208000011231 Crohn disease Diseases 0.000 claims description 2
- 206010051153 Diabetic gastroparesis Diseases 0.000 claims description 2
- 208000008279 Dumping Syndrome Diseases 0.000 claims description 2
- 208000004592 Hirschsprung disease Diseases 0.000 claims description 2
- 206010021518 Impaired gastric emptying Diseases 0.000 claims description 2
- 208000032395 Post gastric surgery syndrome Diseases 0.000 claims description 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 2
- 206010047700 Vomiting Diseases 0.000 claims description 2
- 230000001154 acute effect Effects 0.000 claims description 2
- 208000024330 bloating Diseases 0.000 claims description 2
- 210000005071 external anal sphincter Anatomy 0.000 claims description 2
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims description 2
- 208000001288 gastroparesis Diseases 0.000 claims description 2
- 230000008991 intestinal motility Effects 0.000 claims description 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims description 2
- 230000000291 postprandial effect Effects 0.000 claims description 2
- 230000008673 vomiting Effects 0.000 claims description 2
- 208000017228 Gastrointestinal motility disease Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 208000010643 digestive system disease Diseases 0.000 claims 2
- 210000005095 gastrointestinal system Anatomy 0.000 claims 2
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 2
- 230000002485 urinary effect Effects 0.000 claims 2
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 claims 1
- 201000000708 eosinophilic esophagitis Diseases 0.000 claims 1
- 230000000574 ganglionic effect Effects 0.000 claims 1
- 208000008384 ileus Diseases 0.000 claims 1
- 230000003387 muscular Effects 0.000 claims 1
- 230000004007 neuromodulation Effects 0.000 abstract description 23
- 210000000578 peripheral nerve Anatomy 0.000 abstract description 19
- 206010001497 Agitation Diseases 0.000 abstract description 18
- 230000001976 improved effect Effects 0.000 abstract description 7
- 230000001965 increasing effect Effects 0.000 description 43
- 210000002569 neuron Anatomy 0.000 description 38
- 210000003932 urinary bladder Anatomy 0.000 description 31
- 206010029216 Nervousness Diseases 0.000 description 24
- 239000000835 fiber Substances 0.000 description 21
- 230000010287 polarization Effects 0.000 description 19
- 201000010099 disease Diseases 0.000 description 16
- 230000001734 parasympathetic effect Effects 0.000 description 16
- 210000002820 sympathetic nervous system Anatomy 0.000 description 16
- 210000002161 motor neuron Anatomy 0.000 description 15
- 230000008602 contraction Effects 0.000 description 13
- 230000005284 excitation Effects 0.000 description 13
- 210000001002 parasympathetic nervous system Anatomy 0.000 description 12
- 230000002829 reductive effect Effects 0.000 description 12
- 230000002496 gastric effect Effects 0.000 description 10
- 230000005764 inhibitory process Effects 0.000 description 10
- 210000001617 median nerve Anatomy 0.000 description 10
- 230000009467 reduction Effects 0.000 description 10
- 238000002560 therapeutic procedure Methods 0.000 description 10
- 230000002567 autonomic effect Effects 0.000 description 9
- 230000004064 dysfunction Effects 0.000 description 9
- 238000003780 insertion Methods 0.000 description 9
- 230000037431 insertion Effects 0.000 description 9
- 208000020431 spinal cord injury Diseases 0.000 description 9
- 208000002740 Muscle Rigidity Diseases 0.000 description 8
- 210000004556 brain Anatomy 0.000 description 8
- 230000028327 secretion Effects 0.000 description 8
- 210000002700 urine Anatomy 0.000 description 8
- 230000003750 conditioning effect Effects 0.000 description 7
- 230000003828 downregulation Effects 0.000 description 7
- 210000003811 finger Anatomy 0.000 description 7
- 210000000609 ganglia Anatomy 0.000 description 7
- 210000001428 peripheral nervous system Anatomy 0.000 description 7
- 230000001953 sensory effect Effects 0.000 description 7
- 201000010374 Down Syndrome Diseases 0.000 description 6
- 241000282412 Homo Species 0.000 description 6
- 230000004913 activation Effects 0.000 description 6
- 210000003169 central nervous system Anatomy 0.000 description 6
- 206010008129 cerebral palsy Diseases 0.000 description 6
- 230000007423 decrease Effects 0.000 description 6
- 238000002567 electromyography Methods 0.000 description 6
- 210000002683 foot Anatomy 0.000 description 6
- 210000004247 hand Anatomy 0.000 description 6
- 210000002216 heart Anatomy 0.000 description 6
- 230000004899 motility Effects 0.000 description 6
- 230000008855 peristalsis Effects 0.000 description 6
- 210000000225 synapse Anatomy 0.000 description 6
- 230000009278 visceral effect Effects 0.000 description 6
- 208000012902 Nervous system disease Diseases 0.000 description 5
- 208000025966 Neurological disease Diseases 0.000 description 5
- 208000006011 Stroke Diseases 0.000 description 5
- 238000013459 approach Methods 0.000 description 5
- 230000000632 dystonic effect Effects 0.000 description 5
- 230000007246 mechanism Effects 0.000 description 5
- 230000027939 micturition Effects 0.000 description 5
- 210000004126 nerve fiber Anatomy 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- 210000003497 sciatic nerve Anatomy 0.000 description 5
- 230000003248 secreting effect Effects 0.000 description 5
- 210000002460 smooth muscle Anatomy 0.000 description 5
- 210000001032 spinal nerve Anatomy 0.000 description 5
- 239000000758 substrate Substances 0.000 description 5
- 230000001629 suppression Effects 0.000 description 5
- 230000003827 upregulation Effects 0.000 description 5
- 230000001515 vagal effect Effects 0.000 description 5
- 206010003591 Ataxia Diseases 0.000 description 4
- 206010021118 Hypotonia Diseases 0.000 description 4
- 208000007379 Muscle Hypotonia Diseases 0.000 description 4
- 230000005856 abnormality Effects 0.000 description 4
- 210000004079 adrenergic fiber Anatomy 0.000 description 4
- 210000001142 back Anatomy 0.000 description 4
- 230000003247 decreasing effect Effects 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 210000003127 knee Anatomy 0.000 description 4
- 210000002414 leg Anatomy 0.000 description 4
- 230000033001 locomotion Effects 0.000 description 4
- 201000006417 multiple sclerosis Diseases 0.000 description 4
- 230000037361 pathway Effects 0.000 description 4
- 210000004197 pelvis Anatomy 0.000 description 4
- 206010042772 syncope Diseases 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 210000003813 thumb Anatomy 0.000 description 4
- 210000003384 transverse colon Anatomy 0.000 description 4
- 208000015879 Cerebellar disease Diseases 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 3
- 208000001089 Multiple system atrophy Diseases 0.000 description 3
- 208000018737 Parkinson disease Diseases 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 210000001015 abdomen Anatomy 0.000 description 3
- 210000004100 adrenal gland Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 210000000746 body region Anatomy 0.000 description 3
- 208000029028 brain injury Diseases 0.000 description 3
- 238000004590 computer program Methods 0.000 description 3
- 230000029087 digestion Effects 0.000 description 3
- 230000002222 downregulating effect Effects 0.000 description 3
- 208000024732 dysthymic disease Diseases 0.000 description 3
- 230000002964 excitative effect Effects 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 210000003141 lower extremity Anatomy 0.000 description 3
- 210000000653 nervous system Anatomy 0.000 description 3
- 210000004345 peroneal nerve Anatomy 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 230000036387 respiratory rate Effects 0.000 description 3
- 210000002027 skeletal muscle Anatomy 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 210000000658 ulnar nerve Anatomy 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 208000019901 Anxiety disease Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 208000001953 Hypotension Diseases 0.000 description 2
- 208000026350 Inborn Genetic disease Diseases 0.000 description 2
- 206010021639 Incontinence Diseases 0.000 description 2
- 206010049816 Muscle tightness Diseases 0.000 description 2
- 208000030886 Traumatic Brain injury Diseases 0.000 description 2
- 206010044688 Trisomy 21 Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000036506 anxiety Effects 0.000 description 2
- 210000001815 ascending colon Anatomy 0.000 description 2
- 230000001363 autoimmune Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000007883 bronchodilation Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 210000001638 cerebellum Anatomy 0.000 description 2
- 230000002490 cerebral effect Effects 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 210000003608 fece Anatomy 0.000 description 2
- 210000003099 femoral nerve Anatomy 0.000 description 2
- 208000016361 genetic disease Diseases 0.000 description 2
- 230000036543 hypotension Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000000302 ischemic effect Effects 0.000 description 2
- 238000005304 joining Methods 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 210000004705 lumbosacral region Anatomy 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 210000001595 mastoid Anatomy 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000001577 neostriatum Anatomy 0.000 description 2
- 230000007830 nerve conduction Effects 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 230000002572 peristaltic effect Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000011514 reflex Effects 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 230000036332 sexual response Effects 0.000 description 2
- 201000002859 sleep apnea Diseases 0.000 description 2
- 230000000392 somatic effect Effects 0.000 description 2
- 210000003594 spinal ganglia Anatomy 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000011477 surgical intervention Methods 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 206010043089 tachypnoea Diseases 0.000 description 2
- 210000000457 tarsus Anatomy 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 230000009529 traumatic brain injury Effects 0.000 description 2
- 210000001364 upper extremity Anatomy 0.000 description 2
- 210000003708 urethra Anatomy 0.000 description 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 1
- 229930182837 (R)-adrenaline Natural products 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 description 1
- 206010003840 Autonomic nervous system imbalance Diseases 0.000 description 1
- 206010005052 Bladder irritation Diseases 0.000 description 1
- 208000032170 Congenital Abnormalities Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 208000012239 Developmental disease Diseases 0.000 description 1
- 208000012661 Dyskinesia Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 102000003951 Erythropoietin Human genes 0.000 description 1
- 108090000394 Erythropoietin Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010020852 Hypertonia Diseases 0.000 description 1
- 206010027439 Metal poisoning Diseases 0.000 description 1
- 208000029578 Muscle disease Diseases 0.000 description 1
- 208000021642 Muscular disease Diseases 0.000 description 1
- 206010031127 Orthostatic hypotension Diseases 0.000 description 1
- 206010051482 Prostatomegaly Diseases 0.000 description 1
- 241000220259 Raphanus Species 0.000 description 1
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 description 1
- 102100028255 Renin Human genes 0.000 description 1
- 108090000783 Renin Proteins 0.000 description 1
- 208000032140 Sleepiness Diseases 0.000 description 1
- 206010041277 Sodium retention Diseases 0.000 description 1
- 102000005157 Somatostatin Human genes 0.000 description 1
- 108010056088 Somatostatin Proteins 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 206010065584 Urethral stenosis Diseases 0.000 description 1
- 208000009911 Urinary Calculi Diseases 0.000 description 1
- 206010047139 Vasoconstriction Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000036982 action potential Effects 0.000 description 1
- 230000001919 adrenal effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 210000004960 anterior grey column Anatomy 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 230000037007 arousal Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000003906 autonomic nervous system functioning Effects 0.000 description 1
- 210000000467 autonomic pathway Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 210000005056 cell body Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 208000019902 chronic diarrheal disease Diseases 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 230000008867 communication pathway Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 210000003792 cranial nerve Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 210000001731 descending colon Anatomy 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000007368 endocrine function Effects 0.000 description 1
- 206010014801 endophthalmitis Diseases 0.000 description 1
- 229960005139 epinephrine Drugs 0.000 description 1
- 229940105423 erythropoietin Drugs 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000010304 firing Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000004110 gluconeogenesis Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000009229 glucose formation Effects 0.000 description 1
- 208000010501 heavy metal poisoning Diseases 0.000 description 1
- 230000000004 hemodynamic effect Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000002267 hypothalamic effect Effects 0.000 description 1
- 208000036260 idiopathic disease Diseases 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000001937 intercostal nerve Anatomy 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000003137 locomotive effect Effects 0.000 description 1
- 238000012153 long-term therapy Methods 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000001465 metallisation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000007659 motor function Effects 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 230000024717 negative regulation of secretion Effects 0.000 description 1
- 230000008035 nerve activity Effects 0.000 description 1
- 230000010004 neural pathway Effects 0.000 description 1
- 210000000118 neural pathway Anatomy 0.000 description 1
- 230000007971 neurological deficit Effects 0.000 description 1
- 230000003227 neuromodulating effect Effects 0.000 description 1
- 230000008587 neuronal excitability Effects 0.000 description 1
- 201000001119 neuropathy Diseases 0.000 description 1
- 230000007823 neuropathy Effects 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 206010029864 nystagmus Diseases 0.000 description 1
- 210000000196 olfactory nerve Anatomy 0.000 description 1
- 230000004768 organ dysfunction Effects 0.000 description 1
- 210000004789 organ system Anatomy 0.000 description 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 210000000192 parasympathetic ganglia Anatomy 0.000 description 1
- 210000005034 parasympathetic neuron Anatomy 0.000 description 1
- 230000001936 parietal effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000011458 pharmacological treatment Methods 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 210000002979 radial nerve Anatomy 0.000 description 1
- 230000008085 renal dysfunction Effects 0.000 description 1
- 210000005000 reproductive tract Anatomy 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 210000001044 sensory neuron Anatomy 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 208000013363 skeletal muscle disease Diseases 0.000 description 1
- 230000036558 skin tension Effects 0.000 description 1
- 230000037321 sleepiness Effects 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
- 229960000553 somatostatin Drugs 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 201000001988 urethral stricture Diseases 0.000 description 1
- 208000029584 urinary system neoplasm Diseases 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000025033 vasoconstriction Effects 0.000 description 1
- 230000003639 vasoconstrictive effect Effects 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
- 210000003857 wrist joint Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/08—Arrangements or circuits for monitoring, protecting, controlling or indicating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/205—Applying electric currents by contact electrodes continuous direct currents for promoting a biological process
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36003—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of motor muscles, e.g. for walking assistance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36062—Spinal stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
- A61N1/3615—Intensity
- A61N1/36157—Current
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
- A61N1/3615—Intensity
- A61N1/3616—Voltage density or current density
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biophysics (AREA)
- Electrotherapy Devices (AREA)
- Magnetic Treatment Devices (AREA)
- Gastroenterology & Hepatology (AREA)
- Steroid Compounds (AREA)
- Amplifiers (AREA)
- Amplitude Modulation (AREA)
- Stabilization Of Oscillater, Synchronisation, Frequency Synthesizers (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020197036685A KR102431161B1 (ko) | 2013-12-22 | 2014-12-22 | 트랜스-척추 직류 조절 시스템 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361919806P | 2013-12-22 | 2013-12-22 | |
| US61/919,806 | 2013-12-22 | ||
| US201461925423P | 2014-01-09 | 2014-01-09 | |
| US61/925,423 | 2014-01-09 | ||
| US201462092214P | 2014-12-15 | 2014-12-15 | |
| US62/092,214 | 2014-12-15 | ||
| PCT/US2014/071959 WO2015095880A2 (en) | 2013-12-22 | 2014-12-22 | Trans-spinal direct current modulation systems |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197036685A Division KR102431161B1 (ko) | 2013-12-22 | 2014-12-22 | 트랜스-척추 직류 조절 시스템 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20160105822A true KR20160105822A (ko) | 2016-09-07 |
Family
ID=53403908
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167020164A Withdrawn KR20160105822A (ko) | 2013-12-22 | 2014-12-22 | 트랜스-척추 직류 조절 시스템 |
| KR1020197036685A Active KR102431161B1 (ko) | 2013-12-22 | 2014-12-22 | 트랜스-척추 직류 조절 시스템 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197036685A Active KR102431161B1 (ko) | 2013-12-22 | 2014-12-22 | 트랜스-척추 직류 조절 시스템 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US9283391B2 (enExample) |
| EP (2) | EP3581239B1 (enExample) |
| JP (1) | JP6518251B2 (enExample) |
| KR (2) | KR20160105822A (enExample) |
| CN (2) | CN106029164B (enExample) |
| AU (1) | AU2014368874B2 (enExample) |
| CA (1) | CA2932000C (enExample) |
| CY (1) | CY1122116T1 (enExample) |
| DK (1) | DK3082947T3 (enExample) |
| ES (2) | ES2732734T3 (enExample) |
| HR (1) | HRP20191032T1 (enExample) |
| HU (1) | HUE045175T2 (enExample) |
| IL (1) | IL246430B (enExample) |
| LT (1) | LT3082947T (enExample) |
| MX (1) | MX366919B (enExample) |
| PL (1) | PL3082947T3 (enExample) |
| PT (1) | PT3082947T (enExample) |
| SG (1) | SG11201604288WA (enExample) |
| SI (1) | SI3082947T1 (enExample) |
| WO (1) | WO2015095880A2 (enExample) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9211410B2 (en) | 2009-05-01 | 2015-12-15 | Setpoint Medical Corporation | Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
| WO2014169145A1 (en) | 2013-04-10 | 2014-10-16 | Setpoint Medical Corporation | Closed-loop vagus nerve stimulation |
| US12172017B2 (en) | 2011-05-09 | 2024-12-24 | Setpoint Medical Corporation | Vagus nerve stimulation to treat neurodegenerative disorders |
| US9415218B2 (en) | 2011-11-11 | 2016-08-16 | The Regents Of The University Of California | Transcutaneous spinal cord stimulation: noninvasive tool for activation of locomotor circuitry |
| US20150111918A1 (en) | 2012-03-08 | 2015-04-23 | Medtronic Ardian Luxembourg S.a.r.l | Immune system neuromodulation and associated systems and methods |
| CA2876297C (en) | 2012-06-15 | 2019-02-26 | Case Western Reserve University | Therapy delivery devices and methods for non-damaging neural tissue conduction block |
| US10195434B2 (en) | 2012-06-15 | 2019-02-05 | Case Western Reserve University | Treatment of pain using electrical nerve conduction block |
| US12453853B2 (en) | 2013-01-21 | 2025-10-28 | Cala Health, Inc. | Multi-modal stimulation for treating tremor |
| WO2014113813A1 (en) | 2013-01-21 | 2014-07-24 | Cala Health, Inc. | Devices and methods for controlling tremor |
| AU2014228794B2 (en) | 2013-03-15 | 2019-04-18 | The Regents Of The University Of California | Multi-site transcutaneous electrical stimulation of the spinal cord for facilitation of locomotion |
| US20150238764A1 (en) | 2013-05-10 | 2015-08-27 | Case Western Reserve University | Systems and methods for preventing noise in an electric waveform for neural stimulation, block, or sensing |
| JP2016523125A (ja) | 2013-05-30 | 2016-08-08 | グラハム エイチ． クリーシー | 局所神経性刺激 |
| US11229789B2 (en) | 2013-05-30 | 2022-01-25 | Neurostim Oab, Inc. | Neuro activator with controller |
| EP3903876B1 (en) | 2013-09-16 | 2024-10-23 | The Board of Trustees of the Leland Stanford Junior University | Multi-element coupler for generation of electromagnetic energy |
| EP3049148B1 (en) | 2013-09-27 | 2020-05-20 | The Regents Of The University Of California | Engaging the cervical spinal cord circuitry to re-enable volitional control of hand function in tetraplegic subjects |
| EP3581239B1 (en) * | 2013-12-22 | 2021-05-05 | Research Foundation Of The City University Of New York | Trans-spinal direct current modulation systems |
| US9707391B2 (en) * | 2013-12-22 | 2017-07-18 | The Research Foundation Of The City University Of New York | Method for modulation of effector organs |
| US9707390B2 (en) * | 2013-12-22 | 2017-07-18 | The Research Foundation Of The City University Of New York | Apparatus for modulation of effector organs |
| JP6524339B2 (ja) | 2014-05-18 | 2019-06-05 | ニュースペラ メディカル インク | ミッドフィールドカプラ |
| US20160336813A1 (en) | 2015-05-15 | 2016-11-17 | NeuSpera Medical Inc. | Midfield coupler |
| US10857355B2 (en) * | 2014-05-23 | 2020-12-08 | Albrecht Molsberger | Therapeutically applicable multichannel direct current delivery device |
| AU2015271774B2 (en) | 2014-06-02 | 2020-04-16 | Cala Health, Inc. | Systems and methods for peripheral nerve stimulation to treat tremor |
| EP3183028A4 (en) | 2014-08-21 | 2018-05-02 | The Regents of the University of California | Regulation of autonomic control of bladder voiding after a complete spinal cord injury |
| US10773074B2 (en) | 2014-08-27 | 2020-09-15 | The Regents Of The University Of California | Multi-electrode array for spinal cord epidural stimulation |
| US11311725B2 (en) | 2014-10-24 | 2022-04-26 | Setpoint Medical Corporation | Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation |
| US20190069949A1 (en) | 2014-12-03 | 2019-03-07 | Metavention, Inc. | Systems and methods for modulatng nerves or other tissue |
| US11077301B2 (en) | 2015-02-21 | 2021-08-03 | NeurostimOAB, Inc. | Topical nerve stimulator and sensor for bladder control |
| EP4342516A3 (en) | 2015-06-10 | 2024-07-10 | Cala Health, Inc. | Systems and methods for peripheral nerve stimulation to treat tremor with detachable therapy and monitoring units |
| CN108290038A (zh) * | 2015-08-03 | 2018-07-17 | 加尔瓦尼生物电子有限公司 | 神经调节装置 |
| US11007368B2 (en) * | 2015-08-19 | 2021-05-18 | University Of Louisville Research Foundation, Inc. | Methods for providing optimized neurostimulation |
| WO2017035512A1 (en) | 2015-08-26 | 2017-03-02 | The Regents Of The University Of California | Concerted use of noninvasive neuromodulation device with exoskeleton to enable voluntary movement and greater muscle activation when stepping in a chronically paralyzed subject |
| JP7176949B2 (ja) * | 2015-09-08 | 2022-11-22 | ケース ウェスタン リザーブ ユニバーシティ | 経皮直流電流ブロックによる神経伝導変更システム及び方法 |
| WO2017053847A1 (en) | 2015-09-23 | 2017-03-30 | Cala Health, Inc. | Systems and methods for peripheral nerve stimulation in the finger or hand to treat hand tremors |
| AU2016335931B2 (en) | 2015-10-06 | 2019-06-27 | Case Western Reserve University | High-charge capacity electrodes to deliver direct current nerve conduction block |
| US11097122B2 (en) | 2015-11-04 | 2021-08-24 | The Regents Of The University Of California | Magnetic stimulation of the spinal cord to restore control of bladder and/or bowel |
| US10864373B2 (en) | 2015-12-15 | 2020-12-15 | Case Western Reserve University | Systems for treatment of a neurological disorder using electrical nerve conduction block |
| WO2017127756A1 (en) | 2016-01-20 | 2017-07-27 | Setpoint Medical Corporation | Control of vagal stimulation |
| US11471681B2 (en) | 2016-01-20 | 2022-10-18 | Setpoint Medical Corporation | Batteryless implantable microstimulators |
| JP6952699B2 (ja) | 2016-01-21 | 2021-10-20 | カラ ヘルス, インコーポレイテッドCala Health, Inc. | 過活動膀胱に関連する疾患を治療するための末梢神経調節のためのシステム、方法およびデバイス |
| US10583304B2 (en) | 2016-01-25 | 2020-03-10 | Setpoint Medical Corporation | Implantable neurostimulator having power control and thermal regulation and methods of use |
| IL264116B2 (en) * | 2016-07-08 | 2024-01-01 | Cala Health Inc | Systems and methods for stimulating n nerves with exactly n electrodes and improved dry electrodes |
| IL264904B2 (en) | 2016-08-25 | 2025-05-01 | Cala Health Inc | Systems and methods for treating cardiac dysfunction through peripheral nerve stimulation |
| AU2017251817A1 (en) * | 2016-11-04 | 2018-05-24 | Gimer Medical. Co. Ltd. | Method for reducing overactive bladder syndrome and computer-readable medium thereof |
| AU2017254920B2 (en) * | 2016-11-10 | 2019-04-04 | Gimer Medical Co. Ltd. | Method of reducing renal hypertension and computer-readable medium |
| EP3551280B1 (en) | 2016-12-12 | 2023-08-09 | The Regents of the University of California | Implantable and non-invasive stimulators for gastrointestinal therapeutics |
| ES2922929T3 (es) * | 2016-12-20 | 2022-09-21 | Galvani Bioelectronics Ltd | Dispositivo de neuromodulación |
| WO2021067751A1 (en) | 2019-10-03 | 2021-04-08 | Noctrix Health, Inc. | Peripheral nerve stimulation for restless legs syndrome |
| EP3565631B1 (en) | 2017-01-05 | 2024-04-24 | Noctrix Health, Inc. | Restless leg syndrome or overactive nerve treatment |
| EP4473909A3 (en) | 2017-02-17 | 2025-01-29 | The University of British Columbia | Apparatus and methods for maintaining physiological functions |
| CA3058786A1 (en) | 2017-04-03 | 2018-10-11 | Cala Health, Inc. | Systems, methods and devices for peripheral neuromodulation for treating diseases related to overactive bladder |
| WO2018187237A1 (en) | 2017-04-03 | 2018-10-11 | Presidio Medical, Inc. | Systems and methods for direct current nerve conduction block |
| WO2018217791A1 (en) | 2017-05-23 | 2018-11-29 | The Regents Of The University Of California | Accessing spinal networks to address sexual dysfunction |
| EP3974021B1 (en) | 2017-06-30 | 2023-06-14 | ONWARD Medical N.V. | A system for neuromodulation |
| WO2019036470A1 (en) | 2017-08-14 | 2019-02-21 | Setpoint Medical Corporation | TESTING TEST FOR STIMULATION OF NERVE WAVE |
| EP3706856A4 (en) | 2017-11-07 | 2021-08-18 | Neurostim Oab, Inc. | NON-INVASIVE NERVOUS ACTIVATOR WITH ADAPTIVE CIRCUIT |
| US11992684B2 (en) | 2017-12-05 | 2024-05-28 | Ecole Polytechnique Federale De Lausanne (Epfl) | System for planning and/or providing neuromodulation |
| US12357828B2 (en) | 2017-12-05 | 2025-07-15 | Ecole Polytechnique Federale De Lausanne (Epfl) | System for planning and/or providing neuromodulation |
| CN109999341A (zh) * | 2018-01-04 | 2019-07-12 | 精能医学股份有限公司 | 电刺激器、制造电刺激器的方法及电刺激系统 |
| CN110013605A (zh) * | 2018-01-10 | 2019-07-16 | 精能医学股份有限公司 | 电刺激器、治疗方法及电刺激系统 |
| EP3740274A4 (en) | 2018-01-17 | 2021-10-27 | Cala Health, Inc. | SYSTEMS AND METHODS FOR TREATING INFLAMMATORY INTESTINAL DISEASE USING PERIPHERAL NERVE STIMULATION |
| CA3090776A1 (en) | 2018-02-09 | 2019-08-15 | Presidio Medical, Inc. | Systems and methods for cardiac conduction block |
| CA3091769A1 (en) | 2018-02-20 | 2019-08-29 | Presidio Medical, Inc. | Methods and systems for nerve conduction block |
| KR102141550B1 (ko) | 2018-03-14 | 2020-08-05 | 이화여자대학교 산학협력단 | 비침습적 방광 배뇨 관리 시스템 |
| JP7490561B2 (ja) * | 2018-03-22 | 2024-05-27 | リサーチ ファウンデイション オブ ザ シティー ユニヴァーシティ オブ ニューヨーク | 痙縮および関連障害のための治療戦略としてのニューロンのｎｋｃｃ１の調節 |
| WO2019222619A1 (en) * | 2018-05-17 | 2019-11-21 | Boston Scientific Scimed, Inc. | System for controlling blood pressure |
| US11752329B2 (en) | 2018-07-01 | 2023-09-12 | Presidio Medical, Inc. | Systems and methods for nerve conduction block |
| AU2019301128B2 (en) * | 2018-07-11 | 2024-07-25 | Dignify Therapeutics, Llc | Method of treating voiding dysfunction |
| EP3840825A4 (en) * | 2018-08-21 | 2022-05-18 | The Regents of the University of California | TRANSCUTANEOUS ELECTRICAL AND/OR MAGNETIC BACK STIMULATION FOR BLADDER OR COLON CONTROL IN PEOPLE WITHOUT CNS LESIONS |
| JP2021534877A (ja) | 2018-08-23 | 2021-12-16 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California | 神経根麻痺、馬尾症候群、及び上肢機能の回復のための非侵襲性脊髄刺激 |
| EP4137198A1 (en) | 2018-08-31 | 2023-02-22 | Avation Medical, Inc. | System, method, and apparatus for applying transcutaneous electrical stimulation |
| US11260229B2 (en) | 2018-09-25 | 2022-03-01 | The Feinstein Institutes For Medical Research | Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation |
| CN109173056B (zh) * | 2018-10-19 | 2022-03-22 | 南通大学 | 一种大鼠脊髓神经信号检测与评估系统及方法 |
| US11602633B2 (en) * | 2018-10-22 | 2023-03-14 | Pathmaker Neurosystems Inc. | Method and apparatus for controlling multi-site neurostimulation |
| EP3653256B1 (en) | 2018-11-13 | 2022-03-30 | ONWARD Medical N.V. | Control system for movement reconstruction and/or restoration for a patient |
| EP3695878B1 (en) | 2019-02-12 | 2023-04-19 | ONWARD Medical N.V. | A system for neuromodulation |
| US11617884B2 (en) | 2019-03-15 | 2023-04-04 | Case Western Reserve University | Electrically anesthetizing a peripheral nerve with on-demand electrical nerve block for chronic pain management |
| AU2020272128B9 (en) | 2019-04-12 | 2025-11-20 | Setpoint Medical Corporation | Vagus nerve stimulation to treat neurodegenerative disorders |
| EP3986536A1 (en) * | 2019-06-19 | 2022-04-27 | Galvani Bioelectronics Limited | Neuromodulation device |
| KR20220025834A (ko) | 2019-06-26 | 2022-03-03 | 뉴로스팀 테크놀로지스 엘엘씨 | 적응적 회로를 갖는 비침습적 신경 활성화기 |
| US12337173B2 (en) | 2019-07-30 | 2025-06-24 | Duke University | Devices, systems, and methods for promoting voiding in subjects with underactive bladders |
| US12251560B1 (en) | 2019-08-13 | 2025-03-18 | Cala Health, Inc. | Connection quality determination for wearable neurostimulation systems |
| US11890468B1 (en) | 2019-10-03 | 2024-02-06 | Cala Health, Inc. | Neurostimulation systems with event pattern detection and classification |
| JP2022551604A (ja) * | 2019-10-03 | 2022-12-12 | ノクトリックス ヘルス インコーポレイテッド | むずむず脚症候群のための末梢神経刺激 |
| CN110585597B (zh) * | 2019-10-21 | 2024-04-16 | 中南大学湘雅三医院 | 肠道蠕动智能调节系统 |
| JP2023502507A (ja) | 2019-11-24 | 2023-01-24 | プレシディオ・メディカル・インコーポレイテッド | 電極動作のための制御メカニズムとしての電流バイアス |
| WO2021102448A1 (en) | 2019-11-24 | 2021-05-27 | Presidio Medical, Inc. | Pulse generation and stimulation engine systems |
| EP3827875B1 (en) | 2019-11-27 | 2023-07-05 | ONWARD Medical N.V. | Neuromodulation system |
| DE19211698T1 (de) | 2019-11-27 | 2021-09-02 | Onward Medical B.V. | Neuromodulation system |
| WO2021126921A1 (en) | 2019-12-16 | 2021-06-24 | Neurostim Solutions, Llc | Non-invasive nerve activator with boosted charge delivery |
| IL298193B2 (en) | 2020-05-21 | 2024-01-01 | Feinstein Institutes For Medical Research | Systems and methods for vagus nerve stimulation |
| US12208266B2 (en) | 2020-05-26 | 2025-01-28 | Research Foundation Of The City University Of New York | Multi-site neuromodulation for treatment of ALS and related disorders |
| EP3915470A1 (en) * | 2020-05-26 | 2021-12-01 | ONWARD Medical B.V. | Neuromodulation and/or neurostimulation system |
| KR102554540B1 (ko) * | 2020-07-30 | 2023-07-12 | 재단법인대구경북과학기술원 | 맞춤형 전기 자극 제공 시스템 및 그 방법 |
| WO2022189862A1 (en) | 2021-03-12 | 2022-09-15 | Amber Therapeutics Ltd | Systems for incontinence control |
| US12444497B2 (en) | 2021-05-17 | 2025-10-14 | Setpoint Medical Corporation | Neurostimulation parameter authentication and expiration system for neurostimulation |
| US20250229086A1 (en) * | 2022-01-20 | 2025-07-17 | Setpoint Medical Corporation | Treatment of inflammatory disorders |
| WO2024215761A1 (en) * | 2023-04-10 | 2024-10-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Systems and methods for multichannel individualized stimulation therapy |
| WO2025094661A1 (ja) * | 2023-11-02 | 2025-05-08 | 国立大学法人大阪大学 | 機能的電気刺激装置および機能的電気刺激システム |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5193539A (en) | 1991-12-18 | 1993-03-16 | Alfred E. Mann Foundation For Scientific Research | Implantable microstimulator |
| US6366814B1 (en) * | 1998-10-26 | 2002-04-02 | Birinder R. Boveja | External stimulator for adjunct (add-on) treatment for neurological, neuropsychiatric, and urological disorders |
| US20060122660A1 (en) * | 1998-10-26 | 2006-06-08 | Boveja Birinder R | Method and system for modulating sacral nerves and/or its branches in a patient to provide therapy for urological disorders and/or fecal incontinence, using rectangular and/or complex electrical pulses |
| US6353762B1 (en) * | 1999-04-30 | 2002-03-05 | Medtronic, Inc. | Techniques for selective activation of neurons in the brain, spinal cord parenchyma or peripheral nerve |
| US7155278B2 (en) * | 2003-04-21 | 2006-12-26 | Medtronic, Inc. | Neurostimulation to treat effects of sleep apnea |
| US20100016929A1 (en) * | 2004-01-22 | 2010-01-21 | Arthur Prochazka | Method and system for controlled nerve ablation |
| US20080071321A1 (en) * | 2004-06-10 | 2008-03-20 | Ndi Medical, Inc. | Systems and methods of neuromodulation stimulation for the restoration of sexual function |
| US9205261B2 (en) * | 2004-09-08 | 2015-12-08 | The Board Of Trustees Of The Leland Stanford Junior University | Neurostimulation methods and systems |
| CA2579569C (en) * | 2004-09-08 | 2016-07-05 | Spinal Modulation Inc. | Neurostimulation methods and systems |
| EP1904160B1 (en) * | 2005-06-09 | 2011-12-21 | Medtronic, Inc. | Peripheral nerve field stimulation and spinal cord stimulation |
| CA2637851C (en) * | 2006-01-23 | 2016-01-05 | Rehabtronics Inc. | Method of routing electrical current to bodily tissues via implanted passive conductors |
| US8612019B2 (en) * | 2007-05-23 | 2013-12-17 | Boston Scientific Neuromodulation Corporation | Coupled monopolar and multipolar pulsing for conditioning and stimulation |
| US20090204173A1 (en) * | 2007-11-05 | 2009-08-13 | Zi-Ping Fang | Multi-Frequency Neural Treatments and Associated Systems and Methods |
| US8532779B2 (en) * | 2008-10-31 | 2013-09-10 | Medtronic, Inc. | Implantable medical device crosstalk evaluation and mitigation |
| US8996116B2 (en) * | 2009-10-30 | 2015-03-31 | Setpoint Medical Corporation | Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction |
| US20130053922A1 (en) * | 2009-10-22 | 2013-02-28 | Zaghloul Ahmed | Dipole electrical stimulation employing direct current for recovery from spinal cord injury |
| CN102905757B (zh) * | 2010-03-22 | 2016-02-17 | 纽约城市大学研究基金会 | 电荷增强神经电刺激系统 |
| WO2011156286A2 (en) * | 2010-06-07 | 2011-12-15 | Medtronic, Inc. | Stimulation therapy for bladder dysfunction |
| US9272139B2 (en) * | 2010-07-01 | 2016-03-01 | Marilyn J. Hamilton | Universal closed-loop electrical stimulation system |
| AU2012230699A1 (en) * | 2011-03-24 | 2013-05-23 | California Institute Of Technology | Neurostimulator |
| WO2013036880A1 (en) * | 2011-09-08 | 2013-03-14 | Thacker James R | Selective high frequency spinal cord modulation for inhibiting pain, including cephalic and/or total body pain with reduced side effects, and associated systems and methods |
| EP2785412B1 (en) * | 2011-11-29 | 2017-07-12 | Cardiac Pacemakers, Inc. | Autonomic modulation using peripheral nerve field stimulation |
| US8706240B2 (en) * | 2011-12-09 | 2014-04-22 | Boston Scientific Neuromodulation Corporation | Method for direct modulation of the spinothalamic tract |
| WO2013138252A1 (en) * | 2012-03-16 | 2013-09-19 | Boston Scientific Neuromodulation Corporation | Field augmented current steering using voltage sources |
| WO2013138305A2 (en) * | 2012-03-16 | 2013-09-19 | Boston Scientific Neuromodulation Corporation | System and method for estimating location and depth of stimulation leads |
| CN105283219A (zh) * | 2013-04-05 | 2016-01-27 | 瓦萨姆·艾哈迈德 | 用于气流诊断和恢复的设备和方法 |
| US9707391B2 (en) * | 2013-12-22 | 2017-07-18 | The Research Foundation Of The City University Of New York | Method for modulation of effector organs |
| US9707390B2 (en) * | 2013-12-22 | 2017-07-18 | The Research Foundation Of The City University Of New York | Apparatus for modulation of effector organs |
| EP3581239B1 (en) * | 2013-12-22 | 2021-05-05 | Research Foundation Of The City University Of New York | Trans-spinal direct current modulation systems |
-
2014
- 2014-12-22 EP EP19161879.2A patent/EP3581239B1/en active Active
- 2014-12-22 SG SG11201604288WA patent/SG11201604288WA/en unknown
- 2014-12-22 CA CA2932000A patent/CA2932000C/en active Active
- 2014-12-22 PL PL14872635T patent/PL3082947T3/pl unknown
- 2014-12-22 CN CN201480070353.7A patent/CN106029164B/zh active Active
- 2014-12-22 JP JP2016534630A patent/JP6518251B2/ja active Active
- 2014-12-22 CN CN201811512717.9A patent/CN109432596B/zh active Active
- 2014-12-22 US US14/579,829 patent/US9283391B2/en active Active
- 2014-12-22 SI SI201431236T patent/SI3082947T1/sl unknown
- 2014-12-22 PT PT14872635T patent/PT3082947T/pt unknown
- 2014-12-22 ES ES14872635T patent/ES2732734T3/es active Active
- 2014-12-22 WO PCT/US2014/071959 patent/WO2015095880A2/en not_active Ceased
- 2014-12-22 HR HRP20191032TT patent/HRP20191032T1/hr unknown
- 2014-12-22 MX MX2016007586A patent/MX366919B/es active IP Right Grant
- 2014-12-22 EP EP14872635.9A patent/EP3082947B1/en active Active
- 2014-12-22 AU AU2014368874A patent/AU2014368874B2/en active Active
- 2014-12-22 DK DK14872635.9T patent/DK3082947T3/da active
- 2014-12-22 LT LTEP14872635.9T patent/LT3082947T/lt unknown
- 2014-12-22 ES ES19161879T patent/ES2889099T3/es active Active
- 2014-12-22 KR KR1020167020164A patent/KR20160105822A/ko not_active Withdrawn
- 2014-12-22 HU HUE14872635A patent/HUE045175T2/hu unknown
- 2014-12-22 KR KR1020197036685A patent/KR102431161B1/ko active Active
-
2016
- 2016-02-18 US US15/046,797 patent/US9844668B2/en active Active
- 2016-06-20 IL IL246430A patent/IL246430B/en active IP Right Grant
-
2017
- 2017-11-02 US US15/802,020 patent/US10493270B2/en active Active
-
2019
- 2019-06-13 CY CY20191100617T patent/CY1122116T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102431161B1 (ko) | 트랜스-척추 직류 조절 시스템 | |
| US9707390B2 (en) | Apparatus for modulation of effector organs | |
| US9707391B2 (en) | Method for modulation of effector organs | |
| CN110062643A (zh) | 用于骨盆症状控制的高频神经刺激 | |
| EP3319685B1 (en) | Apparatus for modulation of effector organs | |
| JP7609359B2 (ja) | 超閾値低周波数電気刺激による神経系ブロック | |
| JP2024539635A (ja) | 腸機能および性機能のための仙骨神経調節 | |
| CN101421003A (zh) | 利用电信号来治疗肠梗阻状况的方法和装置 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20160722 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20191029 Comment text: Request for Examination of Application |
|
| A107 | Divisional application of patent | ||
| PA0104 | Divisional application for international application |
Comment text: Divisional Application for International Patent Patent event code: PA01041R01D Patent event date: 20191211 |
|
| PC1202 | Submission of document of withdrawal before decision of registration |
Comment text: [Withdrawal of Procedure relating to Patent, etc.] Withdrawal (Abandonment) Patent event code: PC12021R01D Patent event date: 20191217 |
|
| WITB | Written withdrawal of application |