KR20160101188A - 이미다조피라지논 유도체 - Google Patents
이미다조피라지논 유도체 Download PDFInfo
- Publication number
- KR20160101188A KR20160101188A KR1020167020018A KR20167020018A KR20160101188A KR 20160101188 A KR20160101188 A KR 20160101188A KR 1020167020018 A KR1020167020018 A KR 1020167020018A KR 20167020018 A KR20167020018 A KR 20167020018A KR 20160101188 A KR20160101188 A KR 20160101188A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- compound
- pharmaceutically acceptable
- compounds
- atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- KSMMUGKISAYCEF-UHFFFAOYSA-N OCc(cc1)ccc1C(NC1=O)=C[n]2c1cnc2 Chemical compound OCc(cc1)ccc1C(NC1=O)=C[n]2c1cnc2 KSMMUGKISAYCEF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Lubricants (AREA)
- Developing Agents For Electrophotography (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13006052 | 2013-12-23 | ||
| EP13006052.8 | 2013-12-23 | ||
| PCT/EP2014/003226 WO2015096884A1 (en) | 2013-12-23 | 2014-12-03 | Imidazopyrazinone derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20160101188A true KR20160101188A (ko) | 2016-08-24 |
Family
ID=49916790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167020018A Ceased KR20160101188A (ko) | 2013-12-23 | 2014-12-03 | 이미다조피라지논 유도체 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US9718826B2 (https=) |
| EP (1) | EP3087076B1 (https=) |
| JP (1) | JP6446461B2 (https=) |
| KR (1) | KR20160101188A (https=) |
| CN (1) | CN105829317B (https=) |
| AU (1) | AU2014372896B2 (https=) |
| CA (1) | CA2934663A1 (https=) |
| DK (1) | DK3087076T3 (https=) |
| ES (1) | ES2654403T3 (https=) |
| HR (1) | HRP20171783T1 (https=) |
| HU (1) | HUE037606T2 (https=) |
| IL (1) | IL246406A0 (https=) |
| LT (1) | LT3087076T (https=) |
| MX (1) | MX364859B (https=) |
| NO (1) | NO3087076T3 (https=) |
| PL (1) | PL3087076T3 (https=) |
| PT (1) | PT3087076T (https=) |
| RS (1) | RS56746B1 (https=) |
| RU (1) | RU2672885C2 (https=) |
| SG (1) | SG11201605189YA (https=) |
| SI (1) | SI3087076T1 (https=) |
| TW (1) | TWI637956B (https=) |
| WO (1) | WO2015096884A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TW201822637A (zh) | 2016-11-07 | 2018-07-01 | 德商拜耳廠股份有限公司 | 用於控制動物害蟲的經取代磺醯胺類 |
| CN108403697A (zh) * | 2018-05-02 | 2018-08-17 | 吉林大学 | 吡嗪酮类小分子抑制剂在制备抗肿瘤药物中的应用 |
| IL281212B2 (en) * | 2018-09-07 | 2023-12-01 | Merck Patent Gmbh | 5-Morpholin-4-yl-pyrazolo[4,3-B]pyridine derivatives and their use |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005089352A (ja) | 2003-09-16 | 2005-04-07 | Kissei Pharmaceut Co Ltd | 新規なイミダゾ［１，５−ａ］ピラジン誘導体、それを含有する医薬組成物およびそれらの用途 |
| CN101468988A (zh) * | 2007-12-26 | 2009-07-01 | 上海恒瑞医药有限公司 | 哌嗪类衍生物,其制备方法及其在医药上的应用 |
| EP2526102B1 (en) | 2010-01-22 | 2017-03-08 | Fundación Centro Nacional de Investigaciones Oncológicas Carlos III | Inhibitors of PI3 kinase |
| MX351149B (es) | 2012-03-28 | 2017-10-04 | Merck Patent Gmbh | Derivados biciclicos de pirazinona. |
| CN104271580B (zh) * | 2012-05-04 | 2017-02-22 | 默克专利股份公司 | 吡咯并三嗪酮衍生物 |
-
2014
- 2014-12-03 NO NO14808506A patent/NO3087076T3/no unknown
- 2014-12-03 ES ES14808506.1T patent/ES2654403T3/es active Active
- 2014-12-03 RU RU2016130148A patent/RU2672885C2/ru active
- 2014-12-03 KR KR1020167020018A patent/KR20160101188A/ko not_active Ceased
- 2014-12-03 LT LTEP14808506.1T patent/LT3087076T/lt unknown
- 2014-12-03 DK DK14808506.1T patent/DK3087076T3/da active
- 2014-12-03 PL PL14808506T patent/PL3087076T3/pl unknown
- 2014-12-03 AU AU2014372896A patent/AU2014372896B2/en not_active Ceased
- 2014-12-03 MX MX2016008042A patent/MX364859B/es active IP Right Grant
- 2014-12-03 PT PT148085061T patent/PT3087076T/pt unknown
- 2014-12-03 HR HRP20171783TT patent/HRP20171783T1/hr unknown
- 2014-12-03 JP JP2016542145A patent/JP6446461B2/ja not_active Expired - Fee Related
- 2014-12-03 WO PCT/EP2014/003226 patent/WO2015096884A1/en not_active Ceased
- 2014-12-03 US US15/107,211 patent/US9718826B2/en not_active Expired - Fee Related
- 2014-12-03 CA CA2934663A patent/CA2934663A1/en not_active Abandoned
- 2014-12-03 EP EP14808506.1A patent/EP3087076B1/en active Active
- 2014-12-03 HU HUE14808506A patent/HUE037606T2/hu unknown
- 2014-12-03 RS RS20171341A patent/RS56746B1/sr unknown
- 2014-12-03 SI SI201430528T patent/SI3087076T1/en unknown
- 2014-12-03 CN CN201480070682.1A patent/CN105829317B/zh not_active Expired - Fee Related
- 2014-12-03 SG SG11201605189YA patent/SG11201605189YA/en unknown
- 2014-12-22 TW TW103144858A patent/TWI637956B/zh not_active IP Right Cessation
-
2016
- 2016-06-22 IL IL246406A patent/IL246406A0/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP3087076B1 (en) | 2017-09-27 |
| ES2654403T3 (es) | 2018-02-13 |
| PT3087076T (pt) | 2018-01-03 |
| RS56746B1 (sr) | 2018-03-30 |
| JP6446461B2 (ja) | 2018-12-26 |
| HRP20171783T1 (hr) | 2017-12-29 |
| RU2672885C2 (ru) | 2018-11-20 |
| WO2015096884A1 (en) | 2015-07-02 |
| PL3087076T3 (pl) | 2018-01-31 |
| NO3087076T3 (https=) | 2018-02-24 |
| SI3087076T1 (en) | 2018-01-31 |
| CN105829317A (zh) | 2016-08-03 |
| US20170002010A1 (en) | 2017-01-05 |
| DK3087076T3 (da) | 2017-11-13 |
| CN105829317B (zh) | 2019-03-29 |
| MX364859B (es) | 2019-05-09 |
| AU2014372896A1 (en) | 2016-08-04 |
| MX2016008042A (es) | 2016-09-16 |
| SG11201605189YA (en) | 2016-07-28 |
| LT3087076T (lt) | 2017-12-27 |
| CA2934663A1 (en) | 2015-07-02 |
| AU2014372896B2 (en) | 2018-08-16 |
| TW201605862A (zh) | 2016-02-16 |
| EP3087076A1 (en) | 2016-11-02 |
| JP2017500353A (ja) | 2017-01-05 |
| US9718826B2 (en) | 2017-08-01 |
| RU2016130148A3 (https=) | 2018-07-25 |
| TWI637956B (zh) | 2018-10-11 |
| RU2016130148A (ru) | 2018-01-30 |
| HUE037606T2 (hu) | 2018-09-28 |
| IL246406A0 (en) | 2016-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20160721 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20191128 Comment text: Request for Examination of Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20210927 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 20211210 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20210927 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |