PT3087076T - Derivados de imidazopirazinona - Google Patents

Derivados de imidazopirazinona

Info

Publication number
PT3087076T
PT3087076T PT148085061T PT14808506T PT3087076T PT 3087076 T PT3087076 T PT 3087076T PT 148085061 T PT148085061 T PT 148085061T PT 14808506 T PT14808506 T PT 14808506T PT 3087076 T PT3087076 T PT 3087076T
Authority
PT
Portugal
Prior art keywords
imidazopyrazinone
derivatives
imidazopyrazinone derivatives
Prior art date
Application number
PT148085061T
Other languages
English (en)
Inventor
Dorsch Dieter
Peter Buchstaller Hans
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PT3087076T publication Critical patent/PT3087076T/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/527Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Lubricants (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT148085061T 2013-12-23 2014-12-03 Derivados de imidazopirazinona PT3087076T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13006052 2013-12-23

Publications (1)

Publication Number Publication Date
PT3087076T true PT3087076T (pt) 2018-01-03

Family

ID=49916790

Family Applications (1)

Application Number Title Priority Date Filing Date
PT148085061T PT3087076T (pt) 2013-12-23 2014-12-03 Derivados de imidazopirazinona

Country Status (23)

Country Link
US (1) US9718826B2 (pt)
EP (1) EP3087076B1 (pt)
JP (1) JP6446461B2 (pt)
KR (1) KR20160101188A (pt)
CN (1) CN105829317B (pt)
AU (1) AU2014372896B2 (pt)
CA (1) CA2934663A1 (pt)
DK (1) DK3087076T3 (pt)
ES (1) ES2654403T3 (pt)
HR (1) HRP20171783T1 (pt)
HU (1) HUE037606T2 (pt)
IL (1) IL246406A0 (pt)
LT (1) LT3087076T (pt)
MX (1) MX364859B (pt)
NO (1) NO3087076T3 (pt)
PL (1) PL3087076T3 (pt)
PT (1) PT3087076T (pt)
RS (1) RS56746B1 (pt)
RU (1) RU2672885C2 (pt)
SG (1) SG11201605189YA (pt)
SI (1) SI3087076T1 (pt)
TW (1) TWI637956B (pt)
WO (1) WO2015096884A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TW201822637A (zh) 2016-11-07 2018-07-01 德商拜耳廠股份有限公司 用於控制動物害蟲的經取代磺醯胺類
CN108403697A (zh) * 2018-05-02 2018-08-17 吉林大学 吡嗪酮类小分子抑制剂在制备抗肿瘤药物中的应用
WO2020049017A1 (en) * 2018-09-07 2020-03-12 Merck Patent Gmbh 5-morpholin-4-yl-pyrazolo[4,3-b]pyridine derivatives
JP7433403B1 (ja) 2022-12-06 2024-02-19 本田技研工業株式会社 内燃機関及び鞍乗型車両

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005089352A (ja) * 2003-09-16 2005-04-07 Kissei Pharmaceut Co Ltd 新規なイミダゾ[1,5−a]ピラジン誘導体、それを含有する医薬組成物およびそれらの用途
CN101468988A (zh) * 2007-12-26 2009-07-01 上海恒瑞医药有限公司 哌嗪类衍生物,其制备方法及其在医药上的应用
WO2011089400A1 (en) 2010-01-22 2011-07-28 Centro Nacional De Investigaciones Oncológicas (Cnio) Inhibitors of pi3 kinase
RS54997B1 (sr) * 2012-03-28 2016-11-30 Merck Patent Gmbh Biciklični pirazinon derivati
HUE028325T2 (en) * 2012-05-04 2016-12-28 Merck Patent Gmbh Pyrrolotriazines derivatives

Also Published As

Publication number Publication date
JP2017500353A (ja) 2017-01-05
US9718826B2 (en) 2017-08-01
RU2672885C2 (ru) 2018-11-20
ES2654403T3 (es) 2018-02-13
TW201605862A (zh) 2016-02-16
LT3087076T (lt) 2017-12-27
DK3087076T3 (da) 2017-11-13
EP3087076B1 (en) 2017-09-27
KR20160101188A (ko) 2016-08-24
TWI637956B (zh) 2018-10-11
CN105829317B (zh) 2019-03-29
RS56746B1 (sr) 2018-03-30
NO3087076T3 (pt) 2018-02-24
CA2934663A1 (en) 2015-07-02
MX2016008042A (es) 2016-09-16
RU2016130148A (ru) 2018-01-30
HUE037606T2 (hu) 2018-09-28
EP3087076A1 (en) 2016-11-02
PL3087076T3 (pl) 2018-01-31
RU2016130148A3 (pt) 2018-07-25
AU2014372896B2 (en) 2018-08-16
AU2014372896A1 (en) 2016-08-04
SG11201605189YA (en) 2016-07-28
US20170002010A1 (en) 2017-01-05
JP6446461B2 (ja) 2018-12-26
SI3087076T1 (en) 2018-01-31
CN105829317A (zh) 2016-08-03
HRP20171783T1 (hr) 2017-12-29
MX364859B (es) 2019-05-09
IL246406A0 (en) 2016-08-31
WO2015096884A1 (en) 2015-07-02

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