KR20160092722A - 신규한 락토바실러스 브레비스 박테리오파지 Lac-BRP-1 및 이의 락토바실러스 브레비스 균 증식 억제 용도 - Google Patents
신규한 락토바실러스 브레비스 박테리오파지 Lac-BRP-1 및 이의 락토바실러스 브레비스 균 증식 억제 용도 Download PDFInfo
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Abstract
본 발명은 락토바실러스 브레비스 균을 특이적으로 사멸시킬 수 있는 능력을 갖는 서열번호 1로 표시되는 유전체를 갖는 것을 특징으로 하는 자연으로부터 분리한 시포비리대 박테리오파지 Lac-BRP-1 (수탁번호 KCTC 12659BP), 및 이를 유효성분으로 포함하는 조성물을 이용한 락토바실러스 브레비스 균의 오염을 방지 및 처치하는 방법에 관한 것이다.
Description
본 발명은 락토바실러스 브레비스 균에 감염하여 락토바실러스 브레비스 균을 사멸시킬 수 있는 자연으로부터 분리한 박테리오파지 및 이를 유효성분으로 포함한 조성물을 이용한 바이오에탄올 생산 공정에서의 락토바실러스 브레비스 균 오염을 방지 및 처치하는 방법에 관한 것으로, 더욱 상세하게는 락토바실러스 브레비스 균을 특이적으로 사멸시킬 수 있는 능력을 갖는 서열번호 1로 표시되는 유전체를 갖는 것을 특징으로 하는 자연으로부터 분리한 시포비리대 박테리오파지 Lac-BRP-1 (수탁번호 KCTC 12659BP), 및 상기 박테리오파지를 유효성분으로 포함하는 조성물을 이용한 바이오에탄올 생산 공정에서의 락토바실러스 브레비스 균 오염 방지 및 처치 방법에 관한 것이다.
락토바실러스 브레비스(Lactobacillus brevis) 균은 그람양성간균으로 비운동성이며, 라브레균으로도 불리운다. 락토바실러스 브레비스 균은 아라비노오스(arabinose), 자일로오스(xylose), 글루코오스(glucose), 과당(fructose), 갈락토오스(galactose), 엿당(maltose) 등을 발효하여 젖산(lactic acid)을 생성하는 유산균(Lactic Acid Bacteria, LAB)의 일종이다. 일반적으로 락토바실러스 브레비스 균은 인간의 장(intestines), 질(vagina), 분변(feces) 등에 널리 분포하고 있고, 사우어크라우트(sauerkraut)와 피클(pickles)과 같은 발효식품 내에서 흔히 발견되며 치즈나 김치의 발효 후반에 많이 증식하는 세균으로도 알려져 있다. 인체 내의 위산과 담즙산에 대해 다른 세균보다 저항성이 강한 특징을 가지며 항염증 작용이 뛰어나 잇몸병, 위염증 완화에 효과적이고 인터페론(interferon) 생산능력을 증강시켜 면역력 강화에 도움이 되는 유익 세균이다. 락토바실러스 브레비스 균은 전체유전자 서열분석에 대한 연구가 진행된 바 있는 만큼 관심도가 높은 세균이다(PLoS One 8: e60521, 2013).
그러나 락토바실러스 브레비스 균은 유익한 작용 이외에 맥주 변질(beer spoilage)을 일으키고, 특히 바이오에탄올(Bio-ethanol) 생산 공정에서의 주요 오염 세균 중의 하나로도 알려져 있다. 바이오에탄올 생산 공정에서 락토바실러스 브레비스 균의 오염이 발생하면 바이오에탄올 생산에 사용되어야 할 당류가 락토바실러스 브레비스 균에 의해 소비되어 최종 바이오에탄올 생산성을 크게 낮추게 되고, 이에 더하여 유기산(organic acids)을 다량 발생시켜 바이오에탄올 생산 균주인 효모의 성장을 억제하여 바이오에탄올 생산에 악영향을 미친다. 따라서 바이오에탄올 생산 공정에서 락토바실러스 브레비스 균의 오염에 효과적으로 대처할 방안의 마련이 시급한 상황이다.
화석연료 고갈 및 석유 소비 증가로 인해 고유가 시대를 맞이하게 되었고, 이에 따라 전 세계적으로 대체 에너지에 대한 관심이 그 어느 때보다 높다. 바이오에탄올은 석유의존도를 낮출 수 있는 대체 에너지로서 커다란 가능성을 가진 바이오연료(Bio-fuel)이다. 바이오에탄올은 사탕수수, 밀, 옥수수, 감자, 보리 등의 녹말작물을 발효시켜 생산한다. 바이오에탄올은 화석연료와 달리 사용에 따른 환경오염물질의 발생이 전혀 없다는 장점을 가지며, 다른 대체 에너지원들과는 달리 수송용 연료로도 사용될 수 있다는 장점을 또한 갖고 있다. 이러한 바이오에탄올의 장점을 고려할 때 바이오에탄올 생산 공정에서 락토바실러스 브레비스 균의 오염 문제를 해결할 방안의 마련은 바이오에탄올 생산성 제고에 직접적 효과를 제공하기 때문에 매우 중요한 산업적 의의를 갖는다고 할 수 있다.
최근 박테리아 오염에 대한 대처 방안으로 박테리오파지(bacteriophage)의 활용이 크게 주목을 받고 있다. 특히 자연친화적 방식의 선호로 인하여 박테리오파지에 대한 관심은 어느 때보다 높다고 할 수 있다. 박테리오파지는 세균에 감염하는 아주 작은 미생물로서 보통 파지(phage)라고 줄여서 부르기도 한다. 박테리오파지는 박테리아에 감염(infection)한 후 박테리아 세포 내부에서 증식을 하고, 증식 후 자손 박테리오파지들이 박테리아 밖으로 나올 때 숙주인 박테리아의 세포벽을 파괴하는 방식으로 박테리아를 사멸시키는 능력을 갖고 있다. 박테리오파지의 박테리아 감염 방식은 매우 특이성이 높아서 특정 박테리아에 감염할 수 있는 박테리오파지의 종류는 일부로 한정된다. 즉, 특정 박테리오파지는 특정 범주의 박테리아에만 감염할 수 있고 이로 인하여 특정 박테리오파지는 특정 박테리아만을 사멸시키며 다른 박테리아에는 영향을 주지 않는다.
박테리오파지는 1915년 영국의 세균학자 Twort가 포도상구균(Micrococcus) 집락이 어떤 것에 의해 투명하게 녹는 현상에 대한 연구를 수행하면서 발견되었다. 또한, 1917년에는 프랑스의 세균학자 d'Herelle이 이질환자 변의 여과액 중에 적리균(Shigella disenteriae)을 녹이는 작용을 가진 것이 있다는 것을 발견하고 이에 대한 연구를 통해 독립적으로 박테리오파지를 발견하였으며, 세균을 잡아먹는다는 뜻에서 박테리오파지라고 명명하였다. 이후 이질균, 장티푸스균, 콜레라균 등 여러 병원성 박테리아에 대한 박테리오파지가 계속적으로 발견되었다.
박테리아를 사멸시킬 수 있는 특별한 능력으로 인하여 박테리오파지는 발견 이후 박테리아 감염에 대응하는 방안으로 기대를 모았으며 관련하여 많은 연구들이 있었다. 그러나 항생제의 보급이 일반화되면서 박테리오파지에 대한 연구는 일부 동유럽 국가들 및 구소련에 한정되어서만 명맥이 유지되었다. 그런데 2000년 이후에 항생제 내성균의 증가로 인하여 기존 항생제의 한계성이 나타나고, 기존 항생제의 대체 물질로의 개발 가능성이 부각되면서 다시 박테리오파지가 항-박테리아제로 주목을 받고 있다.
특히 최근 항생제 사용에 대한 정부 차원의 규제가 전 세계적으로 강화됨에 따라 박테리오파지에 대한 관심이 더욱 높아지고 있으며 산업적 활용 사례도 증가하고 있다.
이에, 본 발명자들은 락토바실러스 브레비스 균을 선택적으로 사멸시킬 수 있는 자연으로부터 분리된 박테리오파지를 이용하여 바이오에탄올 생산 공정에서의 락토바실러스 브레비스 균 오염 방지 또는 처치에 활용될 수 있는 조성물을 개발하고, 또 이 조성물을 이용하여 바이오에탄올 생산 공정에서의 락토바실러스 브레비스 균 오염 방지 또는 처치하는 방법을 개발하고자 노력한 끝에, 이에 적합한 박테리오파지를 자연으로부터 분리하고 이 분리된 박테리오파지를 타 박테리오파지와 구별하여 특정 지을 수 있도록 유전체(genome)의 유전자 서열을 확보한 후 상기 박테리오파지를 유효성분으로 한 조성물을 개발한 다음 이 조성물이 바이오에탄올 생산 공정에서의 락토바실러스 브레비스 균의 오염 방지 및 처치에 효과적으로 활용될 수 있음을 확인함으로써 본 발명을 완성하였다.
따라서 본 발명의 목적은 바이오에탄올 생산 공정에서의 주된 오염 균 중의 하나인 락토바실러스 브레비스 균을 특이적으로 사멸시킬 수 있는 능력을 갖는 서열번호 1로 표시되는 유전체를 갖는 것을 특징으로 하는 자연으로부터 분리한 시포비리대(Siphoviridae) 박테리오파지 Lac-BRP-1 (수탁번호 KCTC 12659BP)을 제공하는 것이다.
본 발명의 또 다른 목적은 바이오에탄올 생산 공정에서의 주된 오염 균 중의 하나인 락토바실러스 브레비스 균에 감염하여 락토바실러스 브레비스 균을 사멸시킬 수 있는 분리 박테리오파지 Lac-BRP-1을 유효성분으로 포함하는 바이오에탄올 생산 공정에서의 락토바실러스 브레비스 균 오염을 방지 하는 데에 활용 가능한 조성물을 제공하는 것이다.
본 발명의 또 다른 목적은 바이오에탄올 생산 공정에서의 주된 오염 균 중의 하나인 락토바실러스 브레비스 균에 감염하여 락토바실러스 브레비스 균을 사멸시킬 수 있는 분리 박테리오파지 Lac-BRP-1을 유효성분으로 포함하는 바이오에탄올 생산 공정에서의 락토바실러스 브레비스 균 오염을 처치 하는 데에 활용 가능한 조성물을 제공하는 것이다.
본 발명의 또 다른 목적은 바이오에탄올 생산 공정에서의 주된 오염 균 중의 하나인 락토바실러스 브레비스 균에 감염하여 락토바실러스 브레비스 균을 사멸시킬 수 있는 분리 박테리오파지 Lac-BRP-1을 유효성분으로 포함하는 바이오에탄올 생산 공정에서의 락토바실러스 브레비스 균 오염을 방지 하는 데에 활용 가능한 조성물을 이용한 락토바실러스 브레비스 균 오염 방지 방법을 제공하는 것이다.
본 발명의 또 다른 목적은 바이오에탄올 생산 공정에서의 주된 오염 균 중의 하나인 락토바실러스 브레비스 균에 감염하여 락토바실러스 브레비스 균을 사멸시킬 수 있는 분리 박테리오파지 Lac-BRP-1을 유효성분으로 포함하는 바이오에탄올 생산 공정에서의 락토바실러스 브레비스 균 오염을 처치 하는 데에 활용 가능한 조성물을 이용한 락토바실러스 브레비스 균 오염 처치 방법을 제공하는 것이다.
본 발명은 락토바실러스 브레비스 균을 특이적으로 사멸시킬 수 있는 능력을 갖는 서열번호 1로 표시되는 유전체를 갖는 것을 특징으로 하는 자연으로부터 분리한 시포비리대 박테리오파지 Lac-BRP-1 (수탁번호 KCTC 12659BP), 및 이를 유효성분으로 포함하는 조성물을 이용한 락토바실러스 브레비스 균의 오염 방지 및 처치 방법을 제공한다.
박테리오파지 Lac-BRP-1은 본 발명자들에 의해 분리된 후 2014년 8월 21일자로 한국생명공학연구원 생물자원센터에 기탁되었다 (수탁번호 KCTC 12659BP).
또한, 본 발명은 바이오에탄올 생산 공정에서의 락토바실러스 브레비스 균의 오염을 방지 또는 처치하는 데에 활용될 수 있는 박테리오파지 Lac-BRP-1을 유효성분으로 포함하는 바이오에탄올 생산 공정에서의 락토바실러스 브레비스 균 오염을 방지 또는 처치하는 데에 활용 가능한 조성물을 제공한다.
본 발명의 조성물에 포함되는 박테리오파지 Lac-BRP-1은 락토바실러스 브레비스 균을 효과적으로 사멸시키므로 락토바실러스 브레비스 균의 오염 방지나 처치에 효과를 나타낸다. 따라서 본 발명의 조성물은 바이오에탄올 생산 공정에서의 락토바실러스 브레비스 균 오염 방지 및 처치 목적으로 활용될 수 있다.
본 명세서에서 사용된 “처치”라는 용어는 (i) 바이오에탄올 생산 공정에서의 오염된 락토바실러스 브레비스 균의 증식을 효과적으로 억제; 및 (ii) 바이오에탄올 생산 공정에서의 오염된 락토바실러스 브레비스 균을 감소시키는 것을 의미한다.
본 명세서의 “분리” 또는 “분리된”은 자연 상태로부터 여러 실험 기법을 활용하여 박테리오파지를 분리하는 것과 타 박테리오파지와 구별하여 특정 지을 수 있는 특징을 확보하는 일을 지칭하며, 이에 더하여 생명공학기술로 박테리오파지를 산업적으로 활용할 수 있게끔 증식시키는 것도 포함한다.
본 발명의 조성물은 그 양태에 있어 박테리오파지를 안정하게 함유할 수 있는 형상으로 특별한 제한 없이 구현될 수 있다. 예로, 액상 또는 고상으로 제조될 수 있으며, 고상은 분말형태나 펠릿형태 등 여러 가지 형상으로 제조될 수 있다. 그러나 이에 국한되지 않음은 자명하다.
본 발명의 조성물에는 박테리오파지 안정성 제고나 활성 제고 목적으로 다양한 성분들이 부가적으로 포함될 수 있으며, 이에는 다양한 염류, pH 완충성분, 안정화제, 계면활성제, 습윤제, 유화제, 현탁제, 보존제 등을 포함될 수 있으나, 이에 한정되는 것은 아니다.
본 발명의 조성물에는 박테리오파지 Lac-BRP-1이 유효성분으로 포함된다. 이때 포함되는 박테리오파지 Lac-BRP-1은 1× 101 pfu/㎖ 내지 1× 1030 pfu/㎖ 또는 1× 101 pfu/g 내지 1 × 1030 pfu/g로 포함되며, 바람직하게는 1× 104 pfu/㎖ 내지 1× 1015 pfu/㎖ 또는 1× 104 pfu/g 내지 1× 1015 pfu/g로 포함된다.
본 발명의 조성물은 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자가 용이하게 실시할 수 있는 방법에 따라, 당분야에서 허용되는 담체 및/또는 부형제를 이용하여 제제화 됨으로써 단위 용량 형태로 제조되거나 또는 다용량 용기 내에 내입시켜 제조될 수도 있다.
본 발명의 조성물은 활용 방식에 따라, 이에 국한되지 않지만, 바이오에탄올 생산 공정에 첨가되어 사용되어 질 수 있다. 바이오에탄올 생산 공정 중에 원료 전처리 공정, 액화 공정, 당화 공정, 발효 공정 중 어느 공정에서도 사용할 수 있으나 바람직하게는 발효 공정에서 사용한다.
본 발명의 조성물이나 락토바실러스 브레비스 균의 오염 방지 및 처치 방법이 활용될 수 있는 바이오에탄올 생산 공정은 원료로 사탕수수, 옥수수, 돼지감자, 초목류 등 어떤 것을 사용하는 공정이라도 적용에 있어 문제가 없다.
본 발명의 박테리오파지 Lac-BRP-1을 유효성분으로 포함하는 조성물을 바이오에탄올 생산 공정에서 락토바실러스 브레비스 균의 오염 방지 및 처치 목적으로 사용하면 락토바실러스 브레비스 균의 오염으로 인한 당의 소실을 막을 수 있고 이로 인하여 바이오에탄올의 생산성을 높여줄 수 있다.
한편, 본 발명의 박테리오파지 Lac-BRP-1을 유효성분으로 포함하는 조성물을 이용한 바이오에탄올 생산 공정에서 락토바실러스 브레비스 균의 오염 방지 및 처치 방법은 기존의 항생제 등의 화학물질에 기반을 둔 방식에 비하여 자연친화적이라는 장점을 제공한다. 항생제 등의 화학물질에 기반을 둔 방식에서는 바이오에탄올 생산 공정에서 발생하는 부산물에 항생제 등의 화학물질이 잔류하게 되어 이를 가축사료나 비료 등으로 활용하는 데에 있어 제약이 있었다. 그러나 본 발명의 박테리오파지 Lac-BRP-1을 유효성분으로 포함하는 조성물을 이용하는 방법에서는 바이오에탄올 생산 공정에서 발생하는 부산물을 가축사료나 비료 등으로 제약 없이 사용할 수 있다. 또한 최근에는 항생제 내성균의 발생이 증가하여 항생제를 사용하는 방법의 효과가 계속 떨어지고 있는데, 본 발명의 조성물이나 방법을 사용하면 이러한 항생제 내성균 문제도 해결할 수 있다. 이는 본 발명의 조성물에 유효성분으로 포함되는 박테리오파지 Lac-BRP-1이 락토바실러스 브레비스 균의 기존 항생제에 대한 내성 보유 여부에 관계 없이 항균 효과를 제공해 줄 수 있기 때문이다.
도 1은 박테리오파지 Lac-BRP-1의 전자현미경 사진이다.
도 2는 박테리오파지 Lac-BRP-1의 락토바실러스 브레비스 균에 대한 사멸능을 보여주는 실험 결과이다. 투명한 부분은 박테리아가 용균되어 결과적으로 형성된 용균반이다.
도 2는 박테리오파지 Lac-BRP-1의 락토바실러스 브레비스 균에 대한 사멸능을 보여주는 실험 결과이다. 투명한 부분은 박테리아가 용균되어 결과적으로 형성된 용균반이다.
이하, 실시예에 의거하여 본 발명을 보다 구체적으로 설명하지만, 이들 실시예는 본 발명의 예시일 뿐이며 본 발명의 범위가 이들 실시예에 한정되는 것은 아니다.
실시예 1: 락토바실러스 브레비스 균을 사멸시킬 수 있는 박테리오파지의 분리
락토바실러스 브레비스 균을 사멸시킬 수 있는 박테리오파지의 선별에는 자연 환경으로부터 확보된 시료들을 이용하였다. 한편, 박테리오파지 분리에 사용된 락토바실러스 브레비스 균은 본 발명자들에 의해 미리 분리되어 락토바실러스 브레비스 균으로 동정(identification)된 것이다.
박테리오파지 분리 과정을 상세히 설명하면, 수집된 시료를 락토바실러스 브레비스 균을 1/100 비율로 접종한 MRS(deMan, Rogosa and Sharpe Broth) 배지(프로테오스 펩톤 No.3, 10 g/L; 소고기 추출물, 10 g/L; 효모 추출물, 5 g/L; 덱스트로스, 20 g/L; 폴리소르베이트 80, 1 g/L; 암모니움 아세테이트, 2 g/L; 소듐 아세테이트, 5 g/L; 마그네슘 설페이트, 0.1 g/L; 망가네이즈 설페이트, 0.05 g/L; 디포타슘 포스페이트, 2 g/L)에 함께 첨가한 다음 30℃에서 3-4시간동안 정치배양 하였다. 배양 후, 8,000 rpm에서 20분간 원심분리하여 상등액을 회수하였다. 회수된 상등액에 락토바실러스 브레비스 균을 1/100 비율로 접종한 다음 30℃에서 3-4시간동안 또 다시 정치배양 하였다. 박테리오파지가 시료에 포함되어 있었을 경우 박테리오파지의 수(titer)가 증가될 수 있도록 이러한 과정을 총 5회 반복하였다. 5회 반복 후에 배양액을 8,000 rpm에서 20분간 원심분리 하였다. 원심분리 후, 회수된 상등액을 0.45 ㎛의 필터를 이용하여 여과를 해 주었다. 얻어진 여과액을 사용한 통상의 점적 실험(spot assay)을 통하여 락토바실러스 브레비스 균을 사멸시킬 수 있는 박테리오파지가 있는지를 조사하였다.
상기 점적 실험은 다음과 같이 실시되었다. MRS 배지에 락토바실러스 브레비스 균을 1/100 비율로 접종한 다음 30℃에서 한밤동안 정치배양 하였다. 이렇게 하여 준비된 락토바실러스 브레비스 균 배양액 3 ml (OD600이 2.0)을 MRS-A(deMan, Rogosa and Sharpe-Agar) 평판배지(프로테오스 펩톤 No.3, 10 g/L; 소고기 추출물, 10 g/L; 효모 추출물, 5 g/L; 덱스트로스, 20 g/L; 폴리소르베이트 80, 1 g/L; 암모니움 아세테이트, 2 g/L; 소듐 아세테이트, 5 g/L; 마그네슘 설페이트, 0.1 g/L; 망가네이즈 설페이트, 0.05 g/L; 디포타슘 포스페이트, 2 g/L; 아가, 15 g/L)에 도말(spreading)하였다. 도말한 평판 배지를 클린벤치(clean bench)에서 약 30분 정도 방치하여 도말액이 건조되게 하였다. 건조 후 앞에서 준비한 여과액 10 μl를 락토바실러스 브레비스 균이 도말된 평판 배지 위에 점적하였다. 이를 30분 정도 방치하여 건조시켰다. 건조 후 점적한 평판 배지를 30℃에서 하루 정치 배양한 다음 여과액이 떨어진 위치에 투명환(clear zone)이 생성되는가를 조사하였다. 투명환이 생성되는 여과액의 경우가 락토바실러스 브레비스 균을 사멸 시킬 수 있는 박테리오파지가 포함되어 있다고 판단할 수 있다. 이러한 조사를 통하여 락토바실러스 브레비스 균에 대한 사멸능을 가진 박테리오파지를 포함한 여과액을 확보할 수 있었다.
락토바실러스 브레비스 균에 대한 사멸능을 가진 박테리오파지의 존재가 확인된 여과액을 이용하여 순수 박테리오파지의 분리를 실시하였다. 순수 박테리오파지의 분리에는 통상의 용균반 분석(plaque assay)을 이용하였다. 이를 자세히 설명하면, 용균반 분석에서 형성된 용균반 하나를 멸균된 팁을 이용하여 회수한 다음 이를 락토바실러스 브레비스 균 배양액에 첨가해 주어 30℃에서 4-5 시간 동안 정치배양하였다. 배양 후 8,000 rpm에서 20분간 원심분리하여 상등액을 얻었다. 얻어진 상등액에 50분의 1의 부피로 락토바실러스 브레비스 균 배양액을 첨가해 준 다음 다시 30℃에서 4-5 시간 정치배양해 주었다. 박테리오파지의 수를 증가시키기 위하여 이러한 과정을 최소 5회 이상 실시한 다음 최종적으로 8,000 rpm에서 20분간 원심분리하여 상등액을 얻었다. 얻어진 상등액을 사용하여 다시 용균반 분석을 실시하였다. 통상 순수 박테리오파지의 분리가 상기 과정의 1회로 달성되지 않기 때문에 이때 형성된 용균반을 이용하여 앞 단계를 전체적으로 다시 반복하였다. 이와 같은 과정을 최소 5회 이상 실시하여 순수한 박테리오파지를 포함한 용액을 확보하였다. 통상적으로 순수 박테리오파지의 분리는 형성된 용균반의 크기 및 모양이 모두 유사하게 될 때까지 반복하였다. 그리고 최종적으로는 전자현미경을 통하여 박테리오파지의 순수 분리 여부를 확인하였다. 전자현미경 분석에서 순수 분리가 확인될 때까지 앞에 기술한 과정을 반복하였다. 전자현미경 분석은 통상의 방법에 따라 실시하였다. 이를 간단히 설명하면 다음과 같다. 순수한 박테리오파지를 포함한 용액을 구리 격자(copper grid)에 묻히고 2% 유라닐 아세테이트(Uranyl acetate)로 역염색법(negative staining)과 건조를 수행한 후 투과전자현미경을 통하여 그 형태를 촬영하였다. 순수 분리한 박테리오파지의 전자현미경 사진이 도 1에 제시되어 있다. 형태적 특징으로 판단할 때 신규 확보된 박테리오파지는 시포비리데 박테리오파지에 속함을 확인할 수 있었다.
이런 방식으로 확인된 순수 박테리오파지를 포함한 용액은 다음의 정제 과정을 거쳤다. 순수 박테리오파지를 포함한 용액 전체 부피의 50분의 1의 부피로 락토바실러스 브레비스 균 배양액을 첨가해 준 다음 다시 4-5 시간 배양하였다. 배양 후 8,000 rpm에서 20분간 원심분리하여 상등액을 얻었다. 충분한 수의 박테리오파지가 포함된 액을 얻기 위해 이러한 과정을 총 5회 반복하였다. 최종 원심분리로 얻어진 상등액을 0.45 μm의 필터를 이용하여 여과한 다음 통상의 폴리에틸렌 글리콜(Polyethylene Glycol; PEG) 침전 과정을 실시하였다. 구체적으로, 여과액 100 ml에 10% PEG 8000/0.5 M NaCl이 되게 PEG와 NaCl을 첨가한 다음 4℃에서 2-3시간 동안 정치한 후, 8,000 rpm에서 30분간 원심분리하여 박테리오파지 침전물을 얻었다. 이렇게 얻어진 박테리오파지 침전물을 완충액(buffer; 10 mM Tris-HCl, 10 mM MgSO4, 0.1% Gelatin, pH 8.0) 5 ㎖로 부유시켰다. 이를 박테리오파지 부유액 또는 박테리오파지 액이라 지칭한다.
이렇게 하여 정제된 순수 박테리오파지를 확보할 수 있었고, 이 박테리오파지를 박테리오파지 Lac-BRP-1로 명명한 뒤, 2014년 8월 21일자로 한국생명공학연구원 생물자원센터(수탁번호 KCTC 12659BP)에 기탁하였다.
실시예 2: 박테리오파지 Lac-BRP-1의 유전체 분리 및 서열 분석
박테리오파지 Lac-BRP-1의 유전체를 다음과 같이 분리하였다. 유전체 분리에는 실시예 1에서와 같은 방법으로 얻어진 박테리오파지 부유액을 이용하였다. 먼저 부유액에 포함되어 있을 수 있는 락토바실러스 브레비스 균의 DNA와 RNA를 제거하기 위해, 박테리오파지 부유액 10 ml에 DNase I과 RNase A를 각각 200 U씩 첨가한 다음 37℃에서 30분간 방치하였다. 30분 방치 후에 DNase I과 RNase A의 활성을 제거하기 위해, 0.5 M 에틸렌디아민테트라아세트산(ethylenediaminetetraacetic acid; EDTA) 500 μl를 첨가한 다음 다시 10분간 정치시켰다. 그리고 이를 추가로 10분간 65℃에 정치시킨 다음 박테리오파지 외벽을 와해시키기 위해 proteinase K (20 ㎎/ml) 100 μl를 첨가한 후 37℃에서 20분간 반응시켰다. 그 후 10% 도데실 황산 나트륨염(sodium dodecyl sulfate; SDS) 500 μl를 첨가한 다음 다시 65℃에서 1시간 동안 반응시켰다. 1 시간 반응 후, 이 반응액에 25:24:1의 구성비를 갖는 페놀(phenol) : 클로로포름(chloroform) : 이소아밀알코올(isoamylalcohol)의 혼합액 10 ml를 첨가해 준 후 잘 섞어 주었다. 그리고는 이것을 13,000 rpm에서 15분간 원심분리하여 층이 분리되게 한 다음 분리된 층들 중에서 위층을 취하여 여기에 1.5 부피비의 아이소프로판 알코올(isopropyl alcohol)을 첨가한 다음 13,000 rpm에서 10분간 원심분리하여 유전체를 침전시켰다. 침전물을 회수한 후 침전물에 70% 에탄올(ethanol)을 첨가한 다음 다시 13,000 rpm에서 10분간 원심분리하여 침전물의 세척을 실시하였다. 세척된 침전물을 회수하고 진공 건조 시킨 다음 100 μl의 물에 녹였다. 상기 과정을 반복하여 박테리오파지 Lac-BRP-1의 유전체를 다량 확보하였다.
이렇게 얻어진 유전체를 이용하여 서울대학교 농생명과학공동기기원(National Instrumentation Center for Environmental Management)에서 illumina Mi-Seq 기기를 이용하여 차세대염기서열 분석(Next generation sequencing analysis)을 통하여 박테리오파지 Lac-BRP-1의 유전체 서열분석을 실시하였다. 최종적으로 분석된 박테리오파지 Lac-BRP-1 유전체는 136,174 bp의 크기를 가지며, 전체 유전체 서열은 서열번호 1로 제시되어 있다.
확보된 박테리오파지 Lac-BRP-1의 유전체 서열을 기반으로 Web상의 BLAST (http://www.ncbi.nlm.nih.gov/BLAST/)를 이용하여 기존 알려진 박테리오파지 유전자 서열과의 상동성(similarity)을 조사해 보았다. BLAST 조사 결과, 박테리오파지 Lac-BRP-1의 유전체 서열과 50% 이상의 상동성을 가진 박테리오파지의 유전체 서열은 없었다.
이러한 결과로부터 박테리오파지 Lac-BRP-1은 기존 보고된 박테리오파지들과는 다른 신규한 박테리오파지라 결론지을 수 있었다.
실시예 3: 박테리오파지 Lac-BRP-1의 락토바실러스 브레비스 균에 대한 사멸능 조사
분리된 박테리오파지 Lac-BRP-1의 락토바실러스 브레비스 균에 대한 사멸능을 조사하였다. 사멸능 조사에는 실시예 1에서와 같은 방법으로 점적 실험을 통하여 투명환 생성 여부를 조사하였다. 사멸능 조사에 사용되어진 락토바실러스 브레비스 균들은 본 발명자들에 의해서 분리되어 락토바실러스 브레비스 균으로 동정된 것들로 총 15종이었다. 박테리오파지 Lac-BRP-1은 실험에 대상된 락토바실러스 브레비스 균 중 11종에 대하여 사멸능을 갖고 있었다. 대표적 실험 결과가 도 2에 제시되어 있다. 한편, 박테리오파지 Lac-BRP-1의 스타필로코쿠스 아우레우스(Staphylococcus aureus), 엔테로코쿠스 패칼리스(Enterococcus faecalis), 엔테로코쿠스 패슘(Enterococcus faecium), 스트렙토코쿠스 아갈락티애(Streptococcus agalactiae), 스트렙토코쿠스 우베리스(Streptococcus uberis), 헤모필러스 파라수이스(Haemophilus parasuis), 보데텔라 브론치셉티카(Bordetella bronchiseptica), 및 대장균 (Escherichia coli)에 대한 사멸능 조사도 실시하였는데, 결과로 박테리오파지 Lac-BRP-1은 이들 균종들에 대해서는 사멸능을 갖고 있지 않았다.
이상의 결과로 박테리오파지 Lac-BRP-1은 락토바실러스 브레비스 균에 대하여 특이적인 사멸능을 가지며, 다수의 락토바실러스 브레비스 균에 대하여 항균 효과를 발휘할 수 있음을 확인할 수 있었다. 이는 박테리오파지 Lac-BRP-1이 락토바실러스 브레비스 균의 오염 방지 및 처치 목적의 조성물의 유효성분으로 활용 가능함을 의미한다.
실시예 4: 박테리오파지 Lac-BRP-1의 락토바실러스 브레비스 균의 오염 방지에 대한 실험예
바이오에탄올 생산 조건과 유사한 조건에서의 박테리오파지 Lac-BRP-1의 적용이 락토바실러스 브레비스 균의 오염을 방지할 수 있는지를 조사해 보았다. 300 ml 삼각플라스크 4개에 당밀 배지(molasses medium; 16% total sugar, 0.046% KH2PO4, 0.225% urea)를 100 ml 각각 첨가해 준 다음에 2개의 플라스크는 그대로 두고 2개의 플라스크에만 실시예 1에서와 같은 방식으로 제조한 박테리오파지 Lac-BRP-1의 부유액을 첨가하여 1× 106 pfu/ml 수준의 박테리오파지 농도가 되게 하였다. 그리고 나서는 모든 플라스크에 락토바실러스 브레비스 균을 1× 104 cfu/ml 수준이 되게 첨가하였다. 이를 30℃에서 16 시간 동안을 배양한 다음에 각 플라스크로부터 100 μl씩을 취하여 이를 생리식염수로 십진희석한 다음에 희석액 각각을 MRS-A 평판배지에 도말한 다음에 평판배지들을 30℃ 평판배양기에서 한밤동안 배양하였다. 한밤 배양 후, 형성된 콜로니의 수를 계수하였다. 그리고 계수한 콜로니 수를 근거로 각 플라스크에서의 락토바실러스 브레비스 균 농도를 계산하였다. 그 결과는 다음과 같았다.
구분 | 락토바실러스 브레비스 균 농도 |
박테리오파지 미첨가 플라스크 1 | 대략 106 cfu/ml |
박테리오파지 미첨가 플라스크 2 | 대략 108 cfu/ml |
박테리오파지 첨가 플라스크 1 | 대략 102 cfu/ml |
박테리오파지 첨가 플라스크 2 | 대략 102 cfu/ml |
이 결과로부터 본 발명의 박테리오파지 Lac-BRP-1이 락토바실러스 브레비스 균의 성장을 저해할 뿐만 아니라 사멸까지 시키는 능력이 있음을 확인할 수 있었고, 이로부터 박테리오파지 Lac-BRP-1이 락토바실러스 브레비스 균의 오염을 방지하는 목적의 조성물의 유효성분으로 활용될 수 있다고 결론지을 수 있었다.
실시예 5: 박테리오파지 Lac-BRP-1의 락토바실러스 브레비스 균의 오염 처치에 대한 실험예
바이오에탄올 생산 조건과 유사한 조건에서의 박테리오파지 Lac-BRP-1의 적용이 락토바실러스 브레비스 균의 오염을 처치할 수 있는지를 조사해 보았다. 300 ml 삼각플라스크 4개에 당밀 배지를 100 ml 각각 첨가해 준 다음에 효모(yeast)를 5× 107 cfu/ml 수준이 되게 접종하였다. 그리고 나서는 모든 플라스크에 락토바실러스 브레비스 균을 1× 104 cfu/ml 수준이 되게 첨가하였다. 그 다음에 2개의 플라스크는 그대로 두고 2개의 플라스크에만 실시예 1에서와 같은 방식으로 제조한 박테리오파지 Lac-BRP-1의 부유액을 첨가하여 1× 107 pfu/ml 수준의 박테리오파지 농도가 되게 하였다. 이를 30℃에서 24 시간 동안을 배양한 다음에 각 플라스크로부터 100 μl씩을 취하여 이를 생리식염수로 십진희석한 다음에 희석액 각각을 MRS-A 평판배지에 도말하였다. 도말한 평판배지는 30℃ 평판배양기에서 한밤동안 배양하였다. 한밤 배양 후, 형성된 콜로니의 수를 계수하였다. 그리고 계수한 콜로니 수를 근거로 하여 각 플라스크에서의 락토바실러스 브레비스 균 농도를 계산하였다. 그 결과는 다음과 같았다.
구분 | 락토바실러스 브레비스 균 농도 |
박테리오파지 미첨가 플라스크 1 | 대략 108 cfu/ml |
박테리오파지 미첨가 플라스크 2 | 대략 108 cfu/ml |
박테리오파지 첨가 플라스크 1 | 대략 101 cfu/ml |
박테리오파지 첨가 플라스크 2 | 미검출 |
이 결과로부터 본 발명의 박테리오파지 Lac-BRP-1이 락토바실러스 브레비스 균의 오염을 처치하는 목적의 조성물의 유효성분으로 활용될 수 있다고 결론지을 수 있었다.
실시예 6: 현장적용시험
박테리오파지 Lac-BRP-1의 적용이 바이오에탄올 생산성 제고에 효과가 있는지를 실제 바이오에탄올 생산 공정에서 조사해 보았다. 적용 조성물로는 실시예 1에서와 같은 방식으로 제조한 박테리오파지 Lac-BRP-1의 부유액을 사용하였다. 적용은 효모 크림(yeast cream)에 효모 크림 기준으로 1× 107 pfu/ml 수준으로 적용하는 방식 (시험 ①), 발효 탱크에 발효 부피 기준으로 1× 106 pfu/ml 수준으로 적용하는 방식 (시험 ②), 효모 크림에 효모 크림 기준으로 1× 107 pfu/ml 수준으로 적용하고 발효 탱크에 발효 부피 기준으로 1× 106 pfu/ml 수준으로도 함께 적용하는 방식 (시험 ③), 및 아무 처리하지 않은 방식 (시험 ④)으로 실시하였다. 시험 ④는 대조시험으로 포함시켰다. 시험은 총 10회 실시하였으며 아래는 그 결과이다. 아래 제시에서 에탄올 생산성은 10회의 평균치이며 시험 ④에서의 에탄올 생산성을 100%로 하여 산출하였다.
구분 | 에탄올 생산성 |
시험 ① | 104% |
시험 ② | 106% |
시험 ③ | 107% |
시험 ④ | 100% |
이상의 결과로 본 발명의 박테리오파지 Lac-BRP-1을 포함한 조성물이 바이오에탄올 생산성 제고에 효과가 있음을 확인할 수 있었다.
이상으로 본 발명의 특정한 부분을 상세히 기술하였는바, 당업계의 통상의 지식을 가진 자에게 있어서 이러한 구체적인 기술은 단지 바람직한 구현예일 뿐이며, 이에 본 발명의 범위가 제한되는 것이 아닌 점은 명백하다. 따라서 본 발명의 실질적인 범위는 첨부된 청구항과 그의 등가물에 의하여 정의된다고 할 것이다.
SEQUENCE LISTING
<110> iNtRON Biotechnology, Co. Ltd.
<120> Novel Lactobacillus brevis bacteriophage Lac-BRP-1 and its use
for preventing proliferation of Lactobacillus brevis
<130> KP090383
<160> 1
<170> PatentIn version 3.2
<210> 1
<211> 136174
<212> DNA
<213> Bacteriophage Lac-BRP-1
<400> 1
aataataata ataataatac gttacctcta ttttgacagg agttctggtg cctaactttg 60
acaactcaat taatatatct aattggcttt caccatgctt caattaacct cggcatatat 120
tcagtcaaac tctcaggaag tctgagctac aagaagctat ctcataactt cttcctgcgt 180
tataaagagc tatcagtctc aatggactat atgatggaca caaacattca gattgtattt 240
tagagtaatt gaattcattt tcaatgtctt gtactgccgt aacgttgtgc ctattcaact 300
ggtaagtata agctaactgg tcacccagta ttctcggcat aatcgaactt ttagcatttc 360
tagcgttaag taatagtgca acctattcct gatactagat tcttagccat ctgactcgtc 420
tattatattc gacctttctt accatacctt tataccacag tctatccaca cctatcttat 480
tgctaagata aacatcctag ctccctgtat attattatat aggaattcca catgtataag 540
tatccttgta catgtattat atcaagataa gcccactgca atttgttcaa aaatcttcac 600
gtggttatta gatatattaa ttcagttgtc aaagaactat tttctatata ttaattataa 660
cacattttaa catattatac aacactttcg ttaaatattt aattcttttt gtttcttgta 720
gagagatgtt tgcacaccct tagcccactc agagtgatgt tcttctctaa taacctgacc 780
taactcaata cattctttaa tgctatctgc atcttttgta tcaaattcat acccatcaaa 840
aacatcgtac attaaaacgg acttcttaat acccagacga acctgttctt cttctgtacc 900
tactacagat aagtctgcat agtatacatt aataccgaat tcaactgagt catctaagtt 960
ttgaatagta tattcattat ccacataatt ttctttaatt tcccaatgct ttgggttaaa 1020
tccttctttt agaagtaagt gtacaacaac tgtttttgca agttctaatt cttccactat 1080
aaaggcccct tttctaggta tgcataattt ctgtaaacag tctctgctgg aatcgaacca 1140
acgtcttaag ttttggagac ttttattcta ccgctgaaat aagagactaa aaatacgcgc 1200
acgttgtttc caatggtacc ttatcgtact ccgtacatgc ccgctcttaa tattcattac 1260
aaacattaag cgtacttaat taaaagtata tggtgaaagc tggattcgaa ccaacgctgt 1320
tataggtttg aactatatca tttactagta tactatagtt cctaactaaa ttgagaacat 1380
gaacacggtc atctgaccgc cgcactacct ttatgctatt tcaccaaatt gcaaccatat 1440
aaccttagaa gtaaggttgc tttgcggagt gtcttaccct tgaacaagca cacaatctct 1500
ttacgcgatg atatacgtcc gctacttttt gtctagttta agcttgttta attatgctag 1560
acctacagga gacaagtttc ctttatttac cagaagctat ctggatgggt caaccgggac 1620
ccgattgcgg taatgggagt cgaacccaat atttataggt tatgagccta tcgtgattgt 1680
tccgtttcac tctaccgcat atcaggatag ctggatttga accagcgact tctcgcttac 1740
ttgtagtcct ttgtatgtgt cggaatgtta tatttttcac accattttct tattcctttt 1800
cctgttcttc catacatcct tccaacagcc tcaaagtttt tagtactttt tatggcacat 1860
aataattctt ccttggatat aggaacaggt ttagtcctat ttatgcaagc acacttacga 1920
gaacagcata tttgttctct atccttttta ataaatactt tatgacatac tggacaagtt 1980
gcttgttcat tagttctcct tggcctttta cttctatgac catttttgtt tccataagta 2040
gatgtttgag agtgacaatt aggacatagc catctaagat tctcttttgt attgttagtg 2100
tagtctccat ctatatggtc tatttgtagg gttaaaggtt tattattcca gttaccgcct 2160
attccacaaa ttgaacattt ataatccata tagttatctt taaatacccg tctccgtata 2220
ttacagtatt tggaacctct aatgtatact tcactgtctg gaacagaatt ttcttgtatc 2280
tgtttatttc tgtttacact aatgcctaat tccttcatac gcttttttaa tgggtttgct 2340
tgagacatcg aagagtatcc aatagtactt aatacctctt tgagcgatgt agacttacta 2400
acaattttct ttaactctcg gtctgaaaca ctgtctaata actttatagt atcatctcac 2460
ataaataatt ttactcttta ggcaatgccc ctagtaggag tcgaacctac acggtattac 2520
taccacaagg ttctaaacct tgtatgccta ccaattacat cataggggca tatatggcga 2580
atttcggatt caaaccgaat ttattccggg tcacgtttta atggttgcaa cccccggcgc 2640
tctaatctat aagctaatcc gcctatgctc ctgacaggac tcgaacctgc gacctcctgc 2700
ttacaaagca gatgctctac ccaactgagc tactggagct aactatcata tgtaccctat 2760
cggactcgaa ccgatgaccg atggattaga aatccattgc tctatccaac tgagctaaga 2820
gtacctaata tagattaatt tctctatcaa tctatactta tagtatacca cgttttattg 2880
attaatcaag gattatttaa aattattttt atacgttgta aattgctttc aaattatcgc 2940
tactatactc cataatttga agtttatgat tagccattgt atacccattc tcttcctcat 3000
atgggtcatt taacttaggt gttccaaatt gacgtgtaac tactccatag tcatcattag 3060
ttacctcttt atgataatga ccataatgaa tttctctata cttagcatta ctccactcaa 3120
caggattttc agttgcaaat aacattggaa gtttcttttg tgccttatcc ccgtgagcca 3180
gtaaaatact tacagagcct aaagtaaagc actgacggta atgtgaagta ttgtgaactt 3240
caatctgagg gaatctatct gaaatagcat caataaacat gtagcttaaa tcaaaatcat 3300
gatttccccc tacagaatat aagtatacac tatttgagtt cagcaaagaa aattcaatta 3360
aatcatcata aaatctttta gcgtctgaaa tagccttaat catattaaca tggtctaatt 3420
gagttccttt aaccgtcata gtcttattga cataatctga gtgaaataaa tcaccgccat 3480
tttcaattac aattttatca taacctcgac taataatttc ttttacctga tttaaatgcg 3540
ttaacatatt ttcataattc ataatgccga aatgtaaatc aaataaggga attactaaat 3600
tatttttacc tgatttaatt gtattaactg ttttcgattt aatttcttta ttaaagattt 3660
tagaaaattc tttaggtgta actacatact taggtttaac actaatttta gtttgataag 3720
aagttactcc ctcggactgt ttccaaaagt tacttacatt actaacaatt tcccattctt 3780
ttggattata gtgatgtgct ttaagcaaat cctccggtgt aatatcatgg ccctctacaa 3840
cctctaaaat agtagtagat gtttgtacac catctctatt atatgtttcc ccagttgatt 3900
ggctacttga tttaaaggac atcggttcac ctacagcctg tagtttacgc ctaacacttc 3960
tatctgaaac ctgtaatcct ttgttcttac ttaacttttc tgaaatttca tggctagata 4020
agcccttacc ttttaattta attgcataat caatttcatc ttggttccat tttgacatca 4080
gtcaattcag cccctaacat ttaataatat cttaattata ctctttttat ctttatatag 4140
ttaaaaagcc ctttaagggc tataaatcaa ttccgtgaaa ccatatccaa ttgagtattg 4200
ggaaatcata accaactaag ctacacccta aggatagaaa tagaggtatt ccaaaataaa 4260
aatgaaaaac taataatact agtgttccta taatatatcc aattatattt actcttttaa 4320
taaacttttc aaagctcatt tagtcacctt caataaccag aatgctttat ctctcaccca 4380
cggcttgtca taatttagat aatatccact agaggggtca aaccttttga agtcttcata 4440
gaatacggac ttcttgaagt cttctggata ctttttaatg agtctatcta agtcaaagct 4500
gagatggtcg tataaatcat cacctattag atttttattt aatttgtagt ataggtatgc 4560
atgtattaat acttgacgct ctcgttgatt taattcttat gaactacacc gtggttaaaa 4620
ccacgggttt ctaggaacac tgcatactta cacagcattc taggaatgta gtgcagaggt 4680
tacaactatt taccgcggtt cgttccaaac ctaattagtc tttttaagca tttagaatat 4740
tcttagcggc attaatatcc ctatcatggt gtataccaca attaggacaa gtccattgtc 4800
gaatatctaa agtatgcttt ccatcatcat atccgcagtt actgcaaatt tgagaggtct 4860
ttctaggatt aacagtgact aactgtttcc cataccactc gcatttgtat tctagttgag 4920
aacgcaaagc acgccaagat tgattagcaa tcgctcgagc aagtttgtga tttttaagaa 4980
gatttttggt tttcaaatct tcaattttaa tcacatcata ttgctcgact aactgtttgg 5040
ttagattatg aagatagtta tttcgttgat tagcaatctt ttcactatat ttggctacca 5100
tatgcttagc tttaagatag ttcttaaaat cagatagttc tctaggttca ataaccttat 5160
tgtgtttatc ccaagcaatt tctttcatag cttgtaatcg tctacgagat aaccgtttct 5220
cccaataatg cttcttttta gctaaaagtt tatcaaaacg aatagtagga aatttaatgc 5280
catcactagt aatcattaag tccgctattc ccatatcaat tcctacggac tgattagttt 5340
tttgaagctt tttaacttcg gtatctacta agacaattgc atagaacttt ccagtagaag 5400
ataatctaat agttacattc ttaatcttac cttcaatctg acgaccggac ctaaagtaaa 5460
cagtacctag cttaggtaac ttaagtctat gttcaccaat ctgacaaata ttattgttag 5520
tgtatccaga ttgataactc tgcttaggaa acttacggga tttgaatttt ggatgaccgg 5580
agtgttcttt aaataatttc tgaaatgcct gattgaggtc acggctcaca tgctgtaaac 5640
tagttgattc tgcttgcttt aagaacgggt actcttgctt taagcattta atcagacgat 5700
tcatgccaaa ttcattaacg tatgaacccc cattattata ccgttcaatc tgcatatcaa 5760
gcaactgatt ccagacaaat ctacagcatc caaaattgtt gactattttg tactgttgct 5820
caatactagg gtatatccta gttttgatag cttttaatgg cattatattc acctccttat 5880
atcttaattg tatcatactt tagaataata tgcaattcat cacgtaacta aagtggcgag 5940
ttttctcccc taaattttaa taaatgttag ggtagtatct aaagtaatag gtcccccggt 6000
gaactgctcg ccacataagt aacgagcttc taggaacact acatgcttac acaacattat 6060
agggatgtag tgcagaggtt atagctattt tactaagggc cgttccggcc caatatagtc 6120
ttttatttgt taacttggtt ttcgttaaca actatagtat atctatattt gtcaatagat 6180
attcatttag aatagtccgg aattcatctc gtcactaaag tagcgagctt tctcccctca 6240
gttttgtaaa caggtaccct tatccagctt tacactttct tggtagtttt aagacatact 6300
ggtcatagta ttacttatta ttatcaattt tctcttgcat tctctttaac caaatagggt 6360
attctttatc atttctagct tttaatcggc tagcaatatc atcatattcc ttcttatgct 6420
ccaaatattt attcttcatt accctatttg tttctcctaa ctcaccggaa taaatcccta 6480
aattgggtag cttcttgaaa taactaatag ttttagctaa ttctttatcc cgtttctttt 6540
tataagcctt agcttgttct tctgacatac caccaaggta gtaatcaaaa tagtccttaa 6600
tatctttatc taagttatca tagtcaatta acattattta cacatccaag tctttttata 6660
gtctatccaa gtatttctaa caaactcttc aaaagtatct tccttgaaaa tataatcgta 6720
ccaattataa tattttttct ttacaataat gtcagttcct attttaacat cattcatcat 6780
atcatctaaa gtataatgat aaggctttcc atctagggta taataacaat ctactgtata 6840
aattttatga attatggggc taaaaccatt actcttatac tcattataag acttactaat 6900
gtattttttt acgtctgata tgctataacg agaagcatat tcccaaatgt cccaattatc 6960
atacagtttt ttataaccac ctaaactcat aggaagacca tctgagtcac ctctatttat 7020
aaccctccta gtatgtctac tagctaattt ttttagctga tgcgctgatt ttccattctt 7080
taatactgga ttttttcggt aacttcttga cattctcatc acctacctaa ttttagaatg 7140
atataactaa caatatgtat taaaaatagc cccacctcat cgtatggata gggctatttt 7200
tattaatagt aagactctcc ctctagcctt actatatcaa ctaacaaagg tgcaataaaa 7260
agaactaata tcaccacatc tatagtatac cacaattaaa ttattttaaa agaattaaat 7320
tcctaaatat aatttattta ttttgtctac caattctttt ttagttacag gttccttatt 7380
cttaaactga taaagctcgt cattatgctt tggtttattt agaaacttaa gaattttatg 7440
cttcttaact ttttttgacc tgaaagccat aacaacagta tcaaatacat aactatctgg 7500
caaattatca aagtaagtaa catttagtcc tgtgggatta cttaaatata aataaaagta 7560
accagaatct gttaacactt taaaatagtt taaatcgaca agttctaaac taaattcctt 7620
attattatcc aatactaaac acctcgaaca cgtgcttcat aatttagtgg aattaatcga 7680
ctagaattta acttattttt catcaactga tattcacctt tatagttacc ttctaataaa 7740
tcaattacat taaaatgata taagaaattt aaatcattag ttgggacata agaatcaatc 7800
caataagtta agtggttgaa tgagtatagt aaatcttttc taggcttaga actgatatta 7860
gtatcacctt taatacccga gttaataatt tcttccccta gagatttaac ataatctaat 7920
ccgctagcaa taaattttgg ttcactaact gcatatctag ctctaacacc atctgtagaa 7980
gttaaaccaa gctcaatctt accccgtctt gaaacacttt ctaggttatt aaagattttt 8040
ttataaacat cttggctaac gctttctgta ataacagaaa tactagcaga tgtccgacct 8100
acatacatat ctaaaacaat tgtataaatt cgttcatatg atttcttaat cttaatcacc 8160
tcgattatta actactattc cgtagtatta gtagggtctt cattattttc tgtttcatca 8220
ggttctttag ctgttagctt gtctacagca tcttctaatg tagatactct cttagtcata 8280
tctaacaaac gattattagt tttactaatt tctgtattat taaccttgta aacaccaaag 8340
gataccatca taattgtacc ttctgcggga atagaacgac catcttggaa tttaacatct 8400
accaaaggac cagaaacagg ttctaccaat ccatctaaag agaagattaa tcctaagtta 8460
acagcatccg ttagcaattt agttactctt gactgtgtat accctttagg aattagagag 8520
ttgtctaaat gaactcttag agttacatta gttgagtctt tctccgaatc agaataaccc 8580
tctacatcta aactagaaaa atccaaaaca ttttcatcaa aagtttcagc tacgtcaata 8640
ataaacttta attctcgtga attaaaccca taatcctcaa taggaacaac taaatctctt 8700
aaactaaatc ttttcatttt ttagtaccac ctttaataat tttgtataag agtattatat 8760
cacataatta cattggatta aaaaatccgc ccttgttatt atctaaagcg tcttttaaat 8820
cgctttccgt atatttgtta atagaattat tgcccccact taaactagta gattgaatac 8880
tattatctga gttatgaaga acatcgataa ttctattcat accaaccatg gcataaactg 8940
cggcttgaaa gaagtgtaat tagtacccct agtttcctag tatttaaaag ggtttagact 9000
atatcttaat cctactgttt ggtgtaggat tctctgcttt acttccctaa attaataagg 9060
ttttcttatc tagttctcac tattcccgtt tgaatagcta cctagaagtt tagtcgttag 9120
acctttacag ataattaaat tatctgattt agtacggtgg tcagctctat ccataactac 9180
ttggacttag cctttcttac cagtatattc gttattacta ctactgtagt tattatttta 9240
ctttgcccgt ttaacagagt tttcgacaag gattactcct tgaaggaacc acttggttaa 9300
tccccttcct ttttacggga aatttcttta tgtgtcgtac cattatcatc ttcaacatca 9360
cgaataatga cattcttacc atgttgaata aacagtccta actctctgtc aacatgttta 9420
taaaacccaa tacgtcccat tttaatatga gtgattaata aagtattctg cattaattta 9480
tctaaagtaa ccttagaatt attttcatca aaatgagcat tcgggtcccc attagaacgt 9540
gcacttctaa caaatgctcc gtatactttt cctttgccaa aatacttaat cagtttatta 9600
acataattac cattataccc caagtctggg ataattatat caggttcata cgtgttgaga 9660
acggatacca ttctatgcag gtcggactca atattttcag ttcctgtaga agttggtatt 9720
ctaacgaatt taataaaatc ccaattcccg tcacctttca tgccaagtaa aactaaatgg 9780
tgataatgtg ttccccaatc tatgccagcc gctacataag cataaccatc acgagtatct 9840
ttaggctcag gtaaataatc tctacgattg ttaagaacat cttctttagt tactctaatc 9900
gtttcatctt gataagggta gcctaaagta tagttataaa agaactgtgg cgaggtttgt 9960
aaactatctt ggtatagttt atcagaagta agccaaacag cgttcatttg agagattaag 10020
taccctctcg aacgtgctga atctgtatac ttaggaaccc attcaccatt ataccaacga 10080
gaagactcta aagacttacc gcaatattga caaacatatg ccgttgagcc aggtctaaca 10140
atattagcta ccctatctat tccatcttca tctaaaatct ttaagttctt ttcaaaattc 10200
ataacctgcc atttaccaca atggtcacat tttattgtcc aatatctttg gtctgattct 10260
ttaaacctag catcaatacc aaaatcacta gctgatgggg tactccaacg tctaattagt 10320
ccatatcgat tatcggactt tagggactcc ttgatagaag cttctgctgg ggtttccgca 10380
tatcgttcat actcatccat catagccata ttaatagcaa caccttcaac ttgtgcacta 10440
ccagaacctg aacggaaaaa tatacgtgaa tcccttattg acatttggtc cagagaattg 10500
ttatcaccat ttaataaact tctatagtaa tcacttttct caaattccgg cctaatacga 10560
gatttaacgt ggtcacgcat tctactgata gaagggaacg tgtatagaat actgacatta 10620
tcgaaagaaa aaacatctgc aaaatagatt aaagccataa ccccaacttc actaaacccc 10680
agttgacgac ctttcatgat attaacttct tgcacattag ggtctactaa agactgtaag 10740
ggttcaattt gccaattacg gtgacctata gaacgagaag catcataatt tggaatatca 10800
aatgttactg gatgcccctt aaccttatga tgtttaagaa tataattaat tgggtctaac 10860
attgatatag catagtctaa tctttccggt gtaatctctt taccaccata taaggacttt 10920
acataatttg ccaactgttt accgtccatg cttttccacc tttctaaaat tcattaccgt 10980
tgtctttgtt aagaatatca gcctgtttct tgactagttt agcaacatca tcttcgctca 11040
tattgtctaa tgacttttct agttcaacag gtttcggttt tgtgtcacca ggaagacctg 11100
cggtagaaga atataattta gctaaattaa tagatactgc ggggtgatta ctagttgatt 11160
ctccttcact agccagcatt tgaaaaatag agacaatatc tttaacgtcc ttaatatctc 11220
taaccttaat gctatcacta ttaacagcat ctactagttt tttgctaaga ataaaggccc 11280
ctttttctaa attagattta gttgtctttg aaatatctga tgtttcagga acatcactgt 11340
ccttgttgtt gttgacatac ttattcattt catcaaataa actgctcact aacttgtcac 11400
cctttcttta taacgtaaat agcactcact agtattatag cacagtgaat aacgcatcaa 11460
ttcgtttgca cactggtaat atctaacatt tgctttccaa cttccattta catatgctga 11520
taatttttta ccacaaactg cacaaactct agctgttttg actaatccac tattacgact 11580
tattattttt gtatttttag agtcatttag aagattccgt ctttttagta accatatgtt 11640
tttttcattc gacatgttgt ttaccccctt attgttaata taattatata cccaattgag 11700
gtatttttga ccaattaggg gactaaataa tactctaaaa tcgtcctctt aaattaggac 11760
atttcgtgac ctaattaagc ataatttaac aattttttat gtaattaaat taggacattt 11820
gttgccctaa ttaaaaataa atggattctt gttaatatca ttaactataa aataggaaaa 11880
aacatgtcct aatttaatcc ttactccgac aatgggtttg atgtgatttt tgaaaaaact 11940
tcgtcctatt gtttccctag agtatatata ttattattct ttactaagta attaagtaat 12000
aataaatata taataaatat acttagagaa attttttgat tcaaatcctg attattttta 12060
tcttttttca aatatatttt ctaatgattt ttcaaaaata atcatcaagt tcatttcaat 12120
attttttaaa atacactaac tgtttttcaa aatattaatt atgcaaatat tacatttgta 12180
ataatttgtt atatttatgt aatacctttt gacacatcaa gtgttatact tactaagtaa 12240
gcaagaaaat aaaaatgtta aaaagaaagg ttgattatta ttaatacgaa agtcaagagt 12300
cttattttag gagtatctgc attagttggt atgggggttg caatgacgac aacagcatca 12360
gctaatacaa aatacactgt taaatccgga gactctctat ggaaaatcgc taatgaacac 12420
ggaacaaacg tttctagttt agtaagtctt aaccaatcaa agttaacttc tggctctgct 12480
agttatattt atcccggaga tattttagaa gttggcaaga ctagcgcaaa tacttatact 12540
tacgctaata atcaaaacta taatgtccaa agctcagctg ggtatacaac caataccagt 12600
aatacaagta attattatac taatccacaa acgtctcaaa ataatacaac agtatcttct 12660
gtagggaatt ctaatgcttc tggttccacc tatagtcagt ttatccaagc aggtggtaca 12720
aaggctttat gggacgcaat tgttgttcct gaatccggtg gtaatccttc cgcatcaaat 12780
ggtcaatatc atggtttggg acaaacaaac caaagttggg gtagcggttc agttgcttca 12840
caaaccaaag gtatgattag ttatgctaat agccgttatg gctccgtagc aaatgctgta 12900
tcttatcgac aatcccacaa tatgtggtaa tattttttta aaagtaccgt ggtctaaata 12960
aggctatggt actttttttt atactttcac aatttgatat aatataacta tatgactaat 13020
ttaaaggcaa ccttatatta attaatagca acaaaacagt agaaaggagc tgattatttg 13080
ggaatttttg ataggtttaa cggcaagcca actatttcta gtggtgaaaa tataaataag 13140
gctattaatg atattgagag agactacgtt agtaagagta tgcacgccaa agccaaagca 13200
aataatgcta tttcagttgg ttctttggat gttgatagta gtgactcaac tatggttgac 13260
aaaggttcta ttttgcaaca taaaaagtta cttagaataa aatcaacaaa tatcattgtt 13320
cagtcaatta ttagaacccg tactaatcaa gttgaaaagt attcaagacc tgctcgttat 13380
tcaagtgatg gggttggatt taaaattctc cctaaaaagc ttcccaagga tggtaagtta 13440
tctgctcaaa aattaaatag aattattgaa cttgaagaat ttattcaaaa ctctggtaat 13500
gtttggacag ctcagcgagg tggcgggttt cgtcaattct tatctgaatt tgtgtataat 13560
cggtatgtat atgaccaaat aaatgttgaa ctaattcgag atagtcaagg gaagttagac 13620
cattttaact ttgttgatgc tggtacagtc gttttacatg acttacctaa aagtgcagat 13680
tcccctagaa gttttgacca atatccaaac gaaaacacct ctaaaccaat tcattttaat 13740
gaaaatgaat taactttcgt tgtctataat gctttagccg atgttactag aagagggtat 13800
ggttattcag aagttgaagc ttctctaagt catttaagat tcattgatga cacggaggac 13860
tttaatgcta gattctttgc tcagggtggt actactcgcg gtttgctatt aattaattct 13920
ggttcttctg cggcacaaaa tacggcggga ctaaatagtc ttaggcagga atggcaatca 13980
agcttctctg gtacaaatgg tgcatggaag attccagttg tttccgcaga ggatgctaaa 14040
ttcatcaaca tgactcaaac atctaaagat atggagtttg aaaagtggtt taattttcta 14100
ctaaatattg ttagtgctat tttccaaatg caacctgatg aaattaactt ccctaatccg 14160
ggaggttcta ctggtaaggg tgctggtaat tccattaacg aaggttctac gcaaaaagct 14220
aagatgaaac agtctcaggg taaagggctt gaacctctat taaattatat tgaagacttt 14280
attaataaat atattttgcg tgagattgat gacgactatt actttagatt tactttaggt 14340
gatactaaag atgaattaca acaacaacaa gtaattaatc agaaacttaa aaatggaatg 14400
acacttaatg aagctcgtaa ggaattaggg ttggaacctt tagatagtga gattggagat 14460
ttgccgggag accccgcaac cgttgtacag tttatgcaat tgctaactaa tgaagataag 14520
gttgttcagc aggttaaaca gcactctaat gactacaatc cagacgcatc agataacggt 14580
aaaccggagg aaggtatgcc cgttgaatct gtaactgata ataatattag ctctgacgat 14640
agtaaaaatg tagataatga taatccagat tctaactaat ttgtgtgaat aatcatgata 14700
cctttatatt attatttaga taaaattaat tagtattagt ttggaggtgt taatttacat 14760
gaaagaaaat aaacttaata ttttcctacc tatcgatgct gaattaacag aaaaatcaaa 14820
taacaataga aatagtgata aagatgataa ttcagtaatc gttgccgggt gggcttcaac 14880
accaaagttt gattttcagg gggaaactgt tgacccttta ggaattgatg attcatattt 14940
taaagaccaa ggttggatag attacgaaca tgataaagat aatatcattg gttatccaac 15000
tgaaaatacg tttacagact ctaaacgagg tttgtttgta gaagcaaaac tttttaagaa 15060
taataagtat gttaagtctt taatggattt aattaataac ctgaaagaaa caggttcttc 15120
taggaaatta ggattttcta ttgagggttt tattaacaag cgagatgaaa ataagccctc 15180
aattatccgc aacattcaaa ttactggtat tgctgttact aaaaacccag ctaatccaga 15240
agctacatgg gaaacagtac agaagtctta ttatagtggt ttaactgctg gatatggggt 15300
aacgcctgat actcaggtag atggtggggc actaaaagtt gaatctatgt taggttccat 15360
gaataatatt tctacaatgc taagttctgc ggatgctaac ccagaattgt ttaagcagtt 15420
gggagaccaa ttagcaaata ttattgatga taaccaaaat tcaagtccta tgcttagtca 15480
attgtatctt caaatatttg aggggttgtc aagagatgaa gcacatgatt tactttttaa 15540
aaatgaaagc gaggaatagc tattggatac taaaaaaacg ttaaaagaag ctttaaagag 15600
tttaactgct gaggataaag atgaatctga aaagaatgta atgccttctg ctaaaatgga 15660
taagcctgac ttaagtcatg gtcgtaatgg ggacattcaa cctgaaagtt cagatagcaa 15720
aggtactgct gttcgtgact cagacgaaga agataaaaag aaaaataaag aaccggttgc 15780
taagagtgaa acatcagaaa agagtgaaaa ccctgtatca gaaggaaata aagctgatga 15840
agtagaatca ggtaaagatt ctgatggtgt aggtgcagat gatacagaaa agtctgaaaa 15900
gactagtaaa tcaaatgaaa agcctttaac tcctaagcat acgtccacaa ctaataagtc 15960
agtatgggat gataagcttg aagatattaa taagtcacta gatgctttaa ctaacaacaa 16020
cgaacgcttt aacgaactta tggagaagtt accagatgtt cttgaaacag ttgtaactaa 16080
gtcaattagt agtgttagag aagagcttct aaagagcgta agttctggta agaataagac 16140
atcaatcact gaatctgaaa aggacattga cggaagtcaa gaccaatccc aaaaggatgt 16200
agatagtgat gaagatggtg acgaagtaga taaggacgtt caaaacggta agaacactaa 16260
ggatttaact aagtctgaaa agtctgaaca cgtcaagaag gatgaagacg gcgatgaagg 16320
cgatgacgat gatggtgatg acatggatgc ttctatgggg gataagaagg gtaaggattg 16380
cgctactaaa tctctaaagg gtgtcggtaa ggctgttcaa actgacggag aaggcccaga 16440
agaagcttct aagtctgtag agtcccctgt agttaaaatg actccggaag aggttaagaa 16500
gtctgctact accctagagt tagctgtagc caatcaaaag cgaacagcat ctggcaaacg 16560
ttgggatgac ttagatgaag tatataacat tgctaaatct gctagagaaa caggtaaaga 16620
agaaatttat aagtcagcat tcagtaaatt tacagagact tttaattaat aattaaacaa 16680
aagtgtatac ttctttatat tattactaga acgtaattga ttcataaaat taaaactacg 16740
attaaaatac gaagggattg ttaaaatata tgaacgaaaa taaagcaaaa gaagcgttag 16800
aagaagctaa taagtcatta gtattaaatt cagaacaaga acaggctgtt aagtcagctc 16860
ttacagcagg ttatggtatc gcacctaacg aattatccga tggtggggcc ttgaaggttg 16920
aatcacttga cccagacatc aagaaccaat cctacggtgc taatgattgg acaatctacc 16980
ctcaattggt aggtcaaggt acagttactg ctaagtctac agttgaaaag tatgtaacct 17040
tcttgaagca tggtcgtgtt ggtcattctg ttttccaacc tgaaattggt attagtaatg 17100
ttaactctcc tcacttgaag caaaagactg ttaaccttaa attcttgact gatgttaagc 17160
aatctagttt tgctatgaac tatgccgcta caattgaaga cgcccaaaag attaatgaag 17220
aagactctat cattgttatt ggtaagacca ttgaatgggc tactttctac ggtgattcag 17280
acttaacttc tggtgaaaag ggcgaaggtc ttcaatttga tggtttggct aagttgattg 17340
atgaaagcaa ccatttggac ttacgaggtg gttctcttac accagaagta ttgaacaagg 17400
ctgctacttt aattggggaa gggttcggat atgccacgga tgcttatatg cctattggtg 17460
ttaaggctga cttcggtaac caattcttag gcgctcaacg ggttattgtt ccaagtaatg 17520
aaggtactac tgctggtgtc gatattgacc acttcttatc cgcacgtggt aatattcgcc 17580
tgaatggttc tactattatg gatgctgatg accggttgga tatggaccaa gttcctgatg 17640
cacaagctcc gggtgctcct gtagttacag cagaagaagt taagagcgca ggtggtcaat 17700
tccaaggtga acttaaggat gctgatggcg ttgtatattc acctgccgaa gtaggttctg 17760
ctttgaatta tcgggtaact gctgttggtc atcatggtga ttcttactca tctgatgttg 17820
ctacggctac accaacttct gctgattctg gtatcaagtt gactatcaag ctagatgcta 17880
tgcaacgtga aattccagat tacttggcta tctaccggca atcattagta caggatggaa 17940
ctaaggaacc agaattttat ctagttggta cagttgctac gcgtgaaatg caagaagacg 18000
gtagctttac ctttactgac ttgaatggtc ggattccggg tactgctgat gtctttgttg 18060
gtgaaatgaa gcgtaatgtt attgccttga tggaattcat gccattatca aaggttaact 18120
tggctgttgt tacaactgct gtttcctttg cggtaacgac ttctgttgct ttggcactat 18180
acttgccaaa acgttgggta atgattcaca atgttcgtta caataacgca gttgaaaatc 18240
atatggccgg tgttaactta cgtgcttatg taggtaacaa ataatataat atttaataat 18300
tagagggagt taataacttc ctcttttttg tgttataatg tgggtaatct aaaataatgg 18360
gaagcgaaaa aataatgaaa ttattagctg gaatcttctt agttattgtt ggctttacac 18420
tgttaagcac tattaataac ttagtaaaat atattggaaa tacgaagtgt tacagagaag 18480
gattatcttc acgagaagaa cttgataagt ccgggtatgg tgatttgcga aaatatttta 18540
gtaaatctga atccgaaaaa ttaattagta ttcttaataa gagtgcttat tcttttgtat 18600
ttactgagtt attatttagt attattgtta tctctattta tcctgttcca ctcgcttact 18660
tagttgctat ttcaattgca attgcgtatg aattagctac agatactaag caattaatta 18720
attataataa gtatggagtt attggagaaa cctattcagg acgtaaaaga tactatttag 18780
atgctttcaa tgtagttaca ggtattttgg gatttatttt accaacatta attgtgttaa 18840
ataattaagg gacctataaa gggttccttt ttttattgcc taaatttggt aaacttaggt 18900
tatgtaatac tcttatatta ttaactagat aaaataaaca agttttatta aggaaagggg 18960
acgttttctt gaagccacaa gactacttta aagtaactaa taataagaat gatggtctta 19020
gcatgtttta tggtaatcct aagaaaattc cagacgagtc taggcttagt gaaataactc 19080
tggaagattt agggttcacg gttcaatcag ttaaggacca gttattaggg atggacgatg 19140
acttagttaa tcctgcaaca ggagaacctt atgatgattc aatttataaa aacgttattc 19200
tccgtgcggt tgctacaaca gaaaaagaat taaatattgt aattagacca agagtaaata 19260
acgaaagatt aaactttaat aatactgagt atcagagttt tatgtatcta agaactgctg 19320
aaaagccaat tcttcaagtt gatagattgc ttatacaatt taatggtcaa cctgttatgg 19380
aatttccaga tgagttgatt aaagtaaata acttattcgg tcaaattaat gttcagccaa 19440
ctattctaat gcagtcatct atgagtaact taccaagctc tatggttgtt ggtaactatc 19500
cacaagcagg catgttaggt gttggtggtg ttgttaaccc taactgggta cctcaaatga 19560
ttggtgttag gtatattgct ggtatgattc cacaaccacc aactgacgaa ggtattaatc 19620
gtttctggta tccacatcca gatttaattt cctatgttgc taaaatggcg actgttgaaa 19680
ttcttgaacg ttggggtaga acaattattg gtgctggtat tgccggttac gatattgcta 19740
ttgatggtat tagtagcagt gttaattcaa cacaaagtgc tgaaaatact ggttctactg 19800
ctgatattat gttacttcaa aatgatatga aagatattaa gaatggtctt agagcctact 19860
atggtgataa ctttggcgtt cttagttagg gggatatgtt atgtctgaaa ttgataaaga 19920
tattgattac agtgaccctt attggtttaa aaataagaag ttaaaaaagg attcagagat 19980
taccaagact aagaattcaa ataatattaa tccgacttta cctcgaaata atacgcctag 20040
gcaagacgtt agtagaatcg caggtctatt agagagaaca ggtcttccta ctatttggga 20100
acaggccact ccttgtcctt gcattaatcc agaaactaac cagccaaaaa cagattgtcc 20160
cttgtgtttt ggtagaggtt ttatttatcg ggaaatgcat accctaacca ttgcatatac 20220
ctccgatgac cggggggctt attttggtag tcaaggtcag caagaccacg gggtaactac 20280
tggaactccc caagtgactg aaaatggtat tgaggatggt attgctatta gagatagatt 20340
aactataaag ggaatgaatt tgtctaatac ctacattgct aatgttagtg aaagacgata 20400
tagagatggt tttttaatac cttatcaagt tgttaaattt aataacgtta taagtattga 20460
tgataaattt aatgtctatc aacttaaaca gggtgaagat ttcgaatacg atgctaggag 20520
ttccatgttt aaggttttga atcctaagct taaaggtaaa aatatctcta tgaatctatc 20580
aacacaactt agatattatg tatctaatat cactaaggaa actcgtgtag ctgatattaa 20640
aaagatggaa gataaaaagg tattaactga taacgggaat attaaattag ataattatta 20700
tcgggttgac ttaggtgacg ttaagtattt tagaatgcca aaaaaattag ttcttaggcg 20760
tgaagatatg tttataggtg ctagcgattt tactgctgat agcactaacg aaaaatctaa 20820
atcccatata tttgatgcca aagaatacga tagctcaatt aatcgattta tgggtggtgt 20880
ttaatattgg cagataatga aaactctctg gtaagtttaa acagttcaga aatagataat 20940
gctttaaatt caatgcttaa ttcattaact atatcgactg aatatgctaa ggatttgtcg 21000
gattggatta atcagtcttc cacgggtatg cactctcata gttccggaaa tgacttacta 21060
gtaactaaaa aaggtatgga agcccaagct agatttcagg gaattagttt tgttgatatg 21120
aaagagtttt ttaagaactc acctaatgct aaacaaaaga aaaatggtgg ttggtacttg 21180
attgttccta ttgggcaaaa tgcgacaaat ttaaagtcat cttccccacg ttcattgtgg 21240
aaccagatgt caggtatgga ttttggaaaa acaggtagtt tgtctgatgg ggagactaat 21300
tttttggaac agtcatctaa tcaagaccaa tcgaatgtta ttaatccact taattataac 21360
tggaagtctg ctaatgtaac cagagtatct tcaaaaacag gtaatggttc cagaggacac 21420
tatatttcgt ttagaacggt ttctgacaag tctgacccta actcatggat tgtaggtaga 21480
gaagccttca cagatgataa tacgggtcct gaacagcaag aggacattgc aaacctaatg 21540
cttagtcaga ttgcaaaata taattaaggc ggtgagtata aatggcaatt ccgagtgtag 21600
atacttattt acgcaatgaa gtatcaaaac aaatatcact attacaggag aatccttata 21660
ttgttaagga gaacatctta aaggattttg atgacaaggt agcaagttcg ttcgttaata 21720
ccttttgtaa taccagtaaa ggttctggaa aagaaatacc agtaactttt acttttggta 21780
acaacaagaa tccagcagat gcttttatcg ttatccaatt caagggttcc tccgaaagcg 21840
atgacgatgg ttctttaggc ggtgttatgt ccgaccatga tgttgcggat ggaaacttag 21900
tacaagaagt tagctattta actatagaaa aattaaatgg attctataga gcttactttg 21960
aagttagcca gccaatttct aatttaggag atattagcac tttttcaggt aacttccaaa 22020
ttgatgggaa tcgaatctat attccatatg atgatagtat gcaggatggg ttaaataatt 22080
ctacttataa taaatctatt attacttata gtccacaaga tatagatgtt gacaacaaca 22140
aaaaggttca taaacaaact atattaactg gttatgagtt tattgaaaat tatacgatag 22200
atagcgtatc taataatcaa gacacattaa gatgcctaga tgctatttta aagactatcc 22260
taatttatat gagatataac gctacagagc aaacagaata taaggtagca caacttaaat 22320
ttatgggttc tgacctagtt gcagtaaatt caccagattc tacagtattt ggtgaacaga 22380
ttttctatag aagagcagaa gttagctaca aagtgactta ctctattgaa tcatcgtatg 22440
gtgtattttt aaagaaatta aatgttaacg gaggggttaa atatgaagac atcaacaaag 22500
aataataata agattgacca ttattattct gtaattgatt ttgttaattc tgctaggggt 22560
aactatgatt ttagtctagg aaaagatgaa gggtttattc aatttatgaa gaataaaaac 22620
aagttttata tgctagatga gaaaagtttt attccttact ttaaagaata tttaaataat 22680
tagtaaaaaa gaaaggtggt aaaccacata tggcaaatat tgaagatgat taccaaaagc 22740
tttatcctct atatgcaatt gaacgtcctc atgtagaaat gagttacaat ccagatgcac 22800
taagaggaca agcttctgaa tcagaaaagg ttatcggcat gattggttct gctgataatg 22860
gtaaaccaaa cacattgtac aaggtgactt cactgttaca agcaaagcag atttttggtt 22920
ccggcgaact tgtagatgct ttagagttgg cttggtcaga tgatgctttg ggtggttcta 22980
tttatgcaat gagggttgaa gatgcaactc ctgcgagtct tgttgcaggt ggattaactt 23040
ttaattcaca agtttacgga gataattcta ataaaactca ggtagcgtta gaacgtaatc 23100
caattaataa ctcttatcga gttacagtcg attatgaacc agatagttat cgtcaagttt 23160
atgataactt aggtcagatt tttaacatca gttatacgcc aaatgatgct tcaaaggcta 23220
aagcgactta ctcagttgaa aaagctgatg atggtacagc taagaagttt attttggaca 23280
ttacagatgc taaggaaaag gttactacga ctacaacgtt aaagccagat gatacaacta 23340
cgactacaac gttggcgcct actacaacca cgactacaac tagcacgact aagaaaccaa 23400
ctacgactac aacgacttct actagtacga gtacaacaac aagtacaact acgaagaaag 23460
ttagcgctac tagtatcaag tttgatacta acgtagcaac tgttaaaacg ggtgacgatg 23520
ttcagcttag ttggaaggtt ctaccagagg gtgcagatga tactggaatt actttcaagt 23580
ctgatgcccc aacaattgcg actgtagatg ataaaggtaa agttactagt cttaaagatg 23640
gtacagccaa tatcacaatc tcattgggta gcctaacgga tgccgttaag ttgacgattg 23700
gctcagacca gacaactgat tttaatggaa aaggtcaaaa cttagatgtt gctaattttg 23760
ctgttgaaga tgacgacttg attaacattc accaagtatt tgatttaact tctagcgact 23820
acgggacggt atttgaacta atgaactctc ttagtttaat tcccggaatt actattgcct 23880
tttctaactc atcagacaat agtacaacga atactgctat cctagatgcc gcagaaggcg 23940
ttaacatcat taccgatatt aatgacgtag acaccgcaac tagtgtttgg gctgttatgg 24000
gtgatattgt taacagacta caatacgaca gttatgttag tgttgttgct aacttatcaa 24060
aggagacccc agatactttt ggactaactc cgatgattgg tggtagtaca ggtgtaaccc 24120
ctatttcatg ggccaagaag tttaagccat ttgcacaagt tcctgtttac tacatggttg 24180
ctttaacgca aagtggcgct gttcaagcag aacttaaagc ctttatgaat gaccagtatt 24240
catctggaca ttccatgaga gggtttgtag gtgcaggcta taacgaagca gatggacaac 24300
ttctatctcg aagacttgct cttaaagaag ctcgtttagc cttaattggt agttctggtt 24360
ataagaacat gaaagatgga cgaactcttc atctacccgg atatatgtta gccgcttatg 24420
ctgctggtgt tgcttctggg ctacaaattg gtggtgcctt aaccaacaag tatattgact 24480
tagtttcaat tgaccaagac tttaactctg ctcaattaga tagattaaat tctcagggtg 24540
ttatcattat tgaacctgta atgaatcgtg gtaacgccgc agggttcaga tttatccaag 24600
acgttacgac aaacaactca actaatgaac ctgttaagtc aagaattagt ttgggtgaac 24660
ttactgactt cttgtttgat gacttacgat ttgagcttga aaaacggttt gtaggtgcta 24720
atattcgaca aacttctaag gaccaaatta agaactttgt tgatagctac ctttacaaac 24780
aaaagttaga tactacagga ttagttgtag attatgaccc cgatgatatt caggttcgtt 24840
tggatgctga tattgcttgg attatgttta cagttaagcc tagtcaaaca ttggataaga 24900
ttcttgtgta tggtgcttac cagaacttta ctgattcaac ttcgacaaat aatggctcag 24960
atgcaacaaa tagtagtaat acttctattc ttaactcatc taacccagat attaatgccg 25020
gatatgaatt tagtaatggg gctacagata ccatcacaca cgacagttct aatggaattt 25080
ataactaagg agggatagct aatggcaaga gtcgcagacc agtcagttca aacaggtaat 25140
actatttatc taatgattga aaatacacct atcggtcggg cacaatccct gactgctgaa 25200
cgtagttttg gtaccgaagg tgtttatgaa attggttcta ttatgccgca ggaacatgtg 25260
tttctaagat atacgggaac cgtccaacta gaacgttacc gaatgaagaa acaatcattg 25320
gcaactctag ggttcgccgc acttggtgaa gaggttttag atattccagt tatcgatatt 25380
gtaaccctag acaatttaac taatgaagtt attattgcct atagaggatg ttctattgat 25440
agctataatg aaaactaccg ggctaacgct attacaggtg agtcttctag gttttattat 25500
ttaacatcta ctgctattca gggaactaaa taaaaaataa ataaaaggac acctcatata 25560
gttggggtgt ccttttttgg tgctaagatt tatttcttgt aaaccttctc aggtggtatg 25620
tggataaaaa tcttattacc acgatgatta tcgctaggaa ggattacata aggtttattt 25680
tcaagcttat agtcaatcac ttcggaaaaa tccatatttc ttggattaat cctaataact 25740
ttagttttat ttcctgagta ataaccaaca atataatagc ctatttgatt atcactattt 25800
gattctgtat caacaaatgc taatttaaac gttcgtccaa caaagttatt ttttgcataa 25860
ctgtatgaca tctctgataa tgccggtact ggtcttttca cctcctgata atttgtattg 25920
tatgctggat tggcattaga atagtctggt cctttatgac taaatctatt aacataaata 25980
gaaaatgtta gcacagaaag tgcaattata atattaatgc caacatattt catccaactt 26040
agacctttgt tattcattct atctacttcc ctccatattt agcttttaac gagtttttta 26100
ttagtacagg tgtaattaca cctaattatt tataaccccc ttatatcgca ttatattgcg 26160
ttatttgatg cttataaaaa tattaatgtt tacttaatca cccctttaca aatttttaat 26220
ttaatgatat gataccgtag taaatgaata tagctgataa accggagtgg gtggcgttac 26280
caccgggtga tagctcaaaa aagggtataa aaaccccgaa ggtgtaagaa gccttctccg 26340
ccactaaatc tcttaagttg gagcaaaaca tcatgtcacc cttaagcaag gtggccttga 26400
tttccgacta ccgaagggtg tctacggccc ggacctgaat taacaggtta taattggtag 26460
gagagggaag gactggctct atttagagtg gggctttata cctagatata tagcttagtg 26520
tttaacacag gggtgtttgt aattgctttg acccttaatt ataatctcaa agtagctata 26580
tctagttgtg ggacagtatg acgtaattat aaagcatgaa tctcagcttg ataagcatta 26640
tttgagagaa gactcatgag ttccatgggt cgaaaactcg cgtgataaac taaagcgaag 26700
cataaatcaa gtaactaaag ataattacat agataaataa attaaatata catattaact 26760
cttataggtt tagtattaga taagctactt agtataggag aattacaaca tgtactatta 26820
taattaatat tgtatagata atcagattta tataatattt tatgacaatt actacatgtg 26880
tatatatatt catcataaaa gcataggaat gtattattag tattaccata tagataactt 26940
tcaggactat tggtaactaa tttatgttta ctaagagttg tttcaaacaa cttagagtta 27000
tctttatatt ctttacctga attatataag tataaatgta taccttcatg aaatataact 27060
ttattcaaaa tattgtaatc aataaaactt gatttatata tagattcaga tagttcaata 27120
gtattgttgt taagtatagt gcgtgcacct atcgtattgc ctaaattatt aacaacaata 27180
ctttttttat attctatatt aaaattatct attaaaaatg tatttaaatt attctgtagt 27240
atattcaatt ctacactcaa tacgacacct ccccatatag taatataatt aagcacttag 27300
tttatattaa aaagggaaga aggcatacaa gaaaggtatt taacaaaaaa tactgaaatc 27360
gtgtaatata gagatataaa atattttttt aagaaagtag gtaattattt tgtcagaaaa 27420
tatgagttcg gaagaccaat taaaagactt tgaaaagaaa tttttaaaaa ataaaggaag 27480
tagtcaacag gtagataagc caaaagctac agagagtaag gttaaaagtg agaattcacc 27540
agaggaatct gatatgtcta agattttagg catggtaact gaaatgaaag aaaaggtaga 27600
taaagttact agtgaaaata gtaagcttgc tgaggaaaat aaacggttaa aagaggaacg 27660
tgatgataaa cgacaagcag ttaagactga taaagaaatt aaggctgtaa ctgatgtcat 27720
tcaaggttat cagcagaagt tccataaagt ttatgatttt cctgttacag atggtgaaga 27780
tattcattta gacattacaa tgaaagctcc tactgctggc tcacaagccg caattactaa 27840
ttttgttgtt gccgctacag atggtatgga gtggcctgct gatgcttcta agttcaagta 27900
tgaagctatg ggagcacttt tggtattagg agaggaggtt cccgcttggc ttagtgattt 27960
agatacactt actagaactg atattccagt caagatttat agtgattact tagcttggtg 28020
ggacaagttt taccaataca gacggcagta aatatcataa atctgtagta gatgttggtg 28080
gtataaaaaa cttagttaag tctaatccgg gaagaaatat gtggtctatc atgaaagaat 28140
ttaaagttct tccaaatgac ccattgttac aatcacttag tcaagaacag caagacttca 28200
ttctgttatc tatgtctagg gataatgatg aactgattgc taatgcaaga ggtgactata 28260
ttgatggtga ctttgaggat aaagactttg aagaaattgc cgaattagct gatgaagatg 28320
aagattggga aattatgcgt gaaggtcaag acccagataa aattcacgaa gctgttgtta 28380
gacttactgg tgatactgaa tttgaagacg ctatgcataa taagctcgaa gctaaacgtg 28440
aagagtctta tcataaagaa gaccgtaaac gtgaccttat taaaaatcag catgaattta 28500
ttaaagaaat taaagagtca tctaagaata gtgaaaatgg taagattgat atatccgaag 28560
caatggataa attacagcta aattcaatta gagactctgg tttacaatag aagctattag 28620
gcttctattt acatattaaa attattgtag agaggaagtg taatacttgg ctaaagatat 28680
tgatgttaat ttaaaactta atgcaattaa taccgaagaa gtgcaaagaa aaattaaaga 28740
attaacggat agtcttgaca aataccaaca agcttccaat tctttcgata aaagtttaaa 28800
taaatctaat ggtaatgttg gtaatggtaa ttctgctcaa agtatgtttg attcagctaa 28860
aacatctgtt gatatatcta atgagctaaa gagtaccttg tccgatattc ttcaagcaca 28920
acacggtatg tctaatggaa attcacaagt gtctacccag cagatggatt ctttaaatag 28980
agtcgctagt cagataaccg gagtattttc aagttcacag agtgtgggac taaatccttt 29040
ttctagtcaa ggaagtcagt ttaataatcc taattatgct aaggctcagg attatttaca 29100
aagaggttct ttaactagac cttctacccc aaatggtacg gcagaggaga gattaaatag 29160
tctttctagt cgtaatcagg atagacagca atataattct tttagagatg aaattaataa 29220
gttgacggct atgggtaata acactgagag aactgttaat accgcatcta gtcaccatac 29280
aatttcttat gaaagaaacc aagcattgtc tggtagattc gatgaagcgg gtcagcgtat 29340
tagttcctta tatcatgttg atggtgaggg aaatacttct ggtagtttgg cagaagctag 29400
ggaatcccta gttaatcgtc agaaccaaga atatgagagt cgtaattctt ctacacaaga 29460
tacatctgag tggaatcaac acgataaaga agctgaacaa attggtaagg taatccaaca 29520
atatgattca ttaattaata aaattcagca aacatctaca acttttgata aagctaaaga 29580
tgacttaaat agtggcttat cctctggaaa tattagtgaa caggctaagc gtggtagttt 29640
tggtgatatt ttaagtaccc gtagctttgc tattgccgct aatacaatga atggaatttc 29700
aagtagcgtt ggtaactcta tgtcatctgg taataatgct agattacagt catctaatag 29760
tatagatgct attacactgg ctaatggggc taatggtgtt gataataact ctgataatca 29820
cttattaaat agattagcaa ctttaggagt tagaaatggt acgggttata gtgcaaccga 29880
tatgtcccaa tttgcatcta cttattcaca aaatagtgga aatactaatg tttatgctga 29940
ccagagtgtt gctaataata tgagtcagtt atctaggttc gaaaactttg gaacagggac 30000
aactaatcaa ctgtatagtt ctttaggtgc aatgggagcc ttaaatacag caggtcaatc 30060
aactaattta actaatagta ttgctagtga aatagctggt tcgaatatgc aaggtagggc 30120
aggacaacag ggtcaggctt tgtcaagtat ttatggaaac ttattagcat caggtcatac 30180
acttaataat tctcaggcag ttggcatagc aggttttcag ggtgctatgg cttccacggg 30240
taatcgtgcc ttacaaggtg caagtggagc aactgcttat aatcaactag ctaatggaat 30300
atcaagtaat atgagtaatc ctgctgttcg tatgtcattt ggtggcaata atccaagcta 30360
tgccggtatg gaaggtcaag ctagattaga tatggatatg aacgaagcag gggaacaccc 30420
agaaaaattt agcggtatga ttcagaattt aaagcgaact tatggagcga ataatagtac 30480
aataactgct gatactttga tgaaacaatt tggtatgtca gcagaagcgg ctagaggttt 30540
tgttaaagct tctgatgatg gaacgttaaa tagcaggagt tataatcgat tagcttctaa 30600
gtatagtgga caattaggta cgttgcagaa acaatattct agtcaaggtg atagtacact 30660
aactaatcaa caagctaatg aacaacgtgc taatatatct ggtagtgaag ctttagatgg 30720
tgttagaaat gcaagaaatg ccgcaggctc taatatgtca ggtattgcta ctttaggcgg 30780
taatgtcctt ggcggtgtcg ttactggtgt tgcttctagc atgggttctg tattaggtgc 30840
atccgtacta aaaggtggcg gaggtaagat actaaaaggc acaaagttag gttctctgtt 30900
cggattagga aaaggagcta aggatgttgc tagtgccgca gataaaacag agggtgttgt 30960
tgagggtgct agtggacttt ctgggttatt tggtaaaggt gtaacttctg ctaaaggttt 31020
aattggtaga ggagttacag caactaaggg tcttttatct aaaggtgctg gaaaacttgg 31080
tcttgaaggt ttgtctaaat ttggattaaa aggcgctgaa aaagttggtc ttaaaggtgc 31140
tgaaaaagta ggaagtaagt ttattcccgg tgttggatgg gctatggctg gtatcgatgc 31200
tgtaagaggt gtcggtgata ttgcgaaaga ccctgctaat gctcttaggc accctattaa 31260
gtctgtaggg agcattctag ggttaactag ggtaaatgct aatgaaaagt ctaacagcga 31320
tagtaaagga aaagataagg ctaataataa gtctgaacgg gtattagacc atgcagataa 31380
atggttggtt gattttaatc gaactttaga tagagcagat aggctaatta ctaatgctaa 31440
aggaattaaa ttgggaactg gttcaaagag ttcaaaggct aattctacag atgattccga 31500
tgatggtaaa ctatccggaa gtgcttctaa gaaagctaag caattagcaa gtatgattaa 31560
gaagaagtat cctaaagcta atagcaacgg tatagccgct gttcttggaa attggcaaca 31620
ggaatcagga tttgacccaa ctgctgtaaa ttcatctggt gcaactggat taggtcaatg 31680
gttaggtgga cgtgctgatg acttgaaagc ctatgctaag aaaaaaggca agtcatggaa 31740
agaccccggc ttacaagttg attttgcttt aaatggagat ggctcaaact ctaagatact 31800
aaagcaagta ttatctggta gcggttctgt tgatagttta acagcagatt actataataa 31860
atgggaacgt ccgggagctt ctgataagac gttgcaaaca cgtaaggata atgctaataa 31920
gttagcaaaa catgcaacag gtatgattgc tatgcaacca gaagctggtg ttattagtga 31980
agagtaccca gaagctgttc ttccattgga cccatccaga gcaaataatt ctcgttcaat 32040
acttcaaaat gctaatagga tattggggaa tacaattagt agtccaaata gtaatacagc 32100
aaataattct acatttagtc ctagttatag tgtatctatt ggtaatgttt ctggtagtga 32160
gcaagacgtt caaggattaa aggttcaatt gcaagaagta ttatctaagg ttgctagtca 32220
tgcacaacag cagagtaatc aacgtcaaat gaatttttac tctaagaatt ttaaacgtat 32280
ttaattagtt ggattgagat aagggctatg ttcttgtttc aatccttctg ttgtataata 32340
gatatataga aggtgatttt attgggaaag tcaagtaata attttgaaaa tatgaataat 32400
ccctatgacc ccggaactaa gattaaggtt aacaataaaa gtgataaaaa caacaaaaag 32460
tcaactaaga agaaaaagaa cacaagtaaa aagggactaa tatttaattc agtaactgat 32520
aaacaggata ctgctaatgg tgctggttct gtaggttctg ctaatatatc tggtaaccct 32580
aattggacta atccgtcaac atcagaggat gaaattgata gattaaatat tgtgttttcg 32640
gttgattttt ggactcagta tggattacaa cgggcaacct atactttagg tagggtcgat 32700
aatgatgact tacaggttcc agttgccaca ggaattaaag atgagctatt aggatttact 32760
acaaatgtag atatgaatca gaacacgcca caatttcaag tacagttaag tggtttaaga 32820
gattgggaag atgttttact ccctaacgat tatttagaaa tatctgcaaa agtttacgaa 32880
gattccccaa ggtctaatga ttctacaacg ggtacagctc aatcacctgc atctgcaact 32940
ttaattacag gattaatttc taatattcat aaagtagcag attcacaaca aggatattca 33000
tatgtcatca cttgtcaggg aatgcaaaaa atattagata acattaatct aggtttaccc 33060
tctgacttgg aagctaatgg tggaattttg ctctatgata ttgggcaagc atcagaccct 33120
aacgttaaag gtagttcaga ttctgttgat ggttcaggtg gttggaatgg tagtattcct 33180
aaaggactta aaggtaatct gaaaaagatt gctccatatg ctgaaaagta tggagcaaag 33240
tacaaggtac ttccttctat gattattgcg caatctgttc aggaatcgag tttaggtact 33300
gcagttccta acgagtataa ttggtggggt ttaactggaa gtattggtca tggtacgaca 33360
aatattggtg gttatcctta tactaaattt gatagtttag acgaagctgt tgagtattat 33420
gcttcgtgta tgggtaatgc tagtcctggt aagtcttact gggcagttaa acgtattaga 33480
ggtatcagtg atgctaaaaa ggctattgcg gttcttggtg gggataatag ttatcacgaa 33540
gctagtgcta gttcatatac tagaggacta acaagtgcgt acaatagata taatttaaag 33600
agattcgaca aaaatattca tttttaaggg ggtaaatata atatggcaac taatgatgtg 33660
gcacaaggag ttaaggccat gcaaaacgct cagaataagc aaaataaggg cgttaaagtt 33720
accggaaatt ttggtaagga tatgatacct aaaattccgg gtaagactag taatagttct 33780
aagggaacag aaatactaac taaggctaag aagccagcca aaaaaaagtc tagtaaggac 33840
aatagtaagt caaaagatac tgatgatagt accaatccaa tatctggtgc tggtatttat 33900
ttttacggta gaatgtcagc agatattatt agacaaattt tagatatgtt tatttttgca 33960
gttaaaccac ttagttctga taattctgta aatgattcta ataaaacaaa tggtaaaaag 34020
agcgcttcca gtgcaagtga ttggaattct ttaggagata caaccggtgt tatcaatctg 34080
atgtataatt ataagaacga ctcaggtaag aaattaaaaa taacggattt aattgaaaca 34140
aatattccac cggaggaaga acaagctcag tatttaaaag accagatgac tggtaatggt 34200
tcagcaggta agattaagat atttaacccg gatgaagcta tgattaataa cccccagcag 34260
tttatggcct ataatggttc tgtagcatca ttaattaggg atttatccaa ttcaccattt 34320
aatgagattt tttggacaca tgaacaatct ggtaaagcta agcttaatta tcggcagacc 34380
ccttttgagg aagaggactg gaaaaattta gattatgttg ttgtggatag taaggaactt 34440
ttagattttt cttttgatga aaatgataat gaacaatatt ctattttcag tatatctagt 34500
acgagtatgc taaatgatat tagtattatg tctaaggtcc ctcctattac agatgaccag 34560
aatgaattaa tttctcgtta tggatataaa tatttaccat ctgtacaatc ggattatttc 34620
tacgctcaaa gtagtggtag tggattagat aaagatgatt taaacaaggt ttcaaatgac 34680
cagaacaatc aaacggatga tttgaacgct agtaagtttt acccatcata taatgccttt 34740
attatgtatt ttaaggtaga tagcaaagat ttagtagggg gtaaggataa taaaaagctt 34800
gcaggtttaa cttatactat atccccttct tatggtggag atgctttgta cgagattatt 34860
cagagtgatt tagctaacaa taaaaatgca agtcaaatag tcaaggattc aactgattat 34920
tataataagc atacagatgt tatggtaacg aatcctatat ctgatacggc taaggttact 34980
tctttaaagg ttgcctatgc agaagcaggg gatttaaata agtatttata tgctagttcg 35040
gttttaccgc cccaagaaaa tccatatcca acaagtatga agaatcaagt taatggagga 35100
ttaaagtatg cgttaagtaa aggattagct tatatctctc aacaccctaa atattcagct 35160
caggatattg ttagattatc tgaggggaaa attggcgctg gtcaagctat gagtattatt 35220
aatacttata ttaaaaataa aggaacgatt agctcagatg aatacaccaa tatattaaat 35280
accgtttctc atagtaaaca agtatcaggt gttaatacaa acacaactgt atcgggtgac 35340
ggccaagact ctatctcgcg gtacaatacg taccaaacaa aactgtttaa ttggtatgcg 35400
gataatacta agatgcttag tggaactatg gttattactg gtaagcttgg tgttgagtgt 35460
ggaaagaagt tatattggcg agatgaacgc cgtggatgta attatgaagc ttatattgaa 35520
tcagtttcac aatcttttag ctttatagac ggttggactg taaccattgg ctttaccaga 35580
ggattaaagg tatcagaaca gaatgatgaa aagcgctgga atatgtattg gggacacgga 35640
actcaattta aaggcggatt ttttggtgaa atggttctac aggatattat tacccaagca 35700
gagaaaagtg aagaggattc agatagtagc gataaggata gtgatgatga ttctggggat 35760
acctcgtcaa ctggaaattg ggttgaagct tgtcgtccaa gaccaggaaa tacttggggg 35820
tcacatgatg caggaacaaa ccaactattt ggtaacacaa gacccggatg gcctcatatt 35880
ttccatgatg gatatgatgc gggttctgct aaattttatc catctatata tgctatgcat 35940
tctggtgagg ttgtgtatgc taagccgtgg ggagaactcg gtagtgaaga tagttatatt 36000
gtaattaaaa gtggtgatat atatcacact taccaagaat tttcagcagg aaataatggt 36060
gtattagtat ctaagggtga ccatgttaag actggtaaga agatagcaac tagaacgact 36120
ggctctcatt gtcacgttgg tattagtaaa ggtgggtatg cagttaacgg gctaccatcc 36180
tattcaaagg gtagtggtaa caagagatgg tatgacccag ttgaatttat taagaagcat 36240
aagaagtagg tgatataata atggcagata aagaaatagt tgataacccc tatagagaac 36300
aatcaacatt aacaactaat cgtaatttag tggatgaagt tagtccaaat gttgcaagtt 36360
tatctgtatt tgtggctaag gttgtttcag tagattatga aaaaggaact attggctata 36420
gtgaaaatat atctaatcct aattatctat atcctacagg ttatgcaaaa ctacctgttt 36480
ttaatgctgg taagacagat gaagataagg tttatggtcg ttaccctagc attacaccgg 36540
gtcagagagt tttaattgct ggtggtaata atactaactt tactcctatg gttgtaacct 36600
cttactttga taaccaagac gatgttaagg agttatcacc tcagactaat actgatttta 36660
ctaataactt aagggatgtt tacccatcag gtcagacaag ttctgtatat gctaatggtg 36720
actatttaag aacttttaat ggtagctcat tcttttatgt ttggttggat tctaaagtag 36780
aagaagaggg aatatcccta tgggatgact atttatatga tatgaatggg aatcctgtta 36840
tttctggatt atatcaggtt gctaatgact ataaggatta tgacatggaa agtcaatcac 36900
aaaatgttgc ttttgttcat aactctaatt ctgatttaga tactcataaa acagtattta 36960
tgattaataa attaggtgaa ttattaattg atttcggtga taaagattta acagatagaa 37020
atttattaag attgaccgca tctgaaacag gtggactcga tgtaatcaag tcaatggatt 37080
atgaccacga aaatttagat aattcagatt attatttaaa gtttggtatt actaaagatg 37140
atactattga ttttaaatac cacaatggtc caactagtac aggaatttca gttactaaag 37200
aaggtactta cgttgatggg gtattagttg cttcaagaaa caacgttgaa aatctatcaa 37260
cagatttaaa aacgttagaa gacaatttta atattttaaa tgataagatg gcatctttag 37320
gaacagattt ttttaataaa ttacgaagtg atattactca ggcgcaaaat gatattaatt 37380
tgttattctc taatacctct actatgagtg cagatatagc tagtaataaa tcagatatat 37440
ctgttatcag agggaatata acgggtattt taagttggca aagtgaagct aataattcat 37500
ttcatgatat taatacaaag ataagtacac taagttcaga aatgtcaaca aggctaacta 37560
atattgaaaa taggctacct agtggaacaa ttactacaca aagttatgta gattctgaaa 37620
ttaataaaat taaggttagt tacgttacta atgacactta tacagtatta gtcaacaggg 37680
tgtcatcttt agaaaatgaa aataaagtat taaatactag tttaacagag ttaaaaaata 37740
attcagtatc gaaaacggat tatgagagtt tagtagaacg agtagaagct ttagaaagta 37800
agtaaaaaat gtcctcacac gtgtggggac ttttcttata ttaaaaagaa aaaggggttg 37860
ttataatgat aggggttagt ggaaaagact caaatatgaa attgcaaaga gtcgccttta 37920
gacaatataa taatgatgga acagttaaga atacttatag atttaatatt aatccctcta 37980
attttcagga gaactttaat gctcggaata tatttatgca gacagaatcc agcattcaaa 38040
tgcaaggctt cggtcaaggt ttgcatacga taacaatttc tggtacgaca ggtgttagaa 38100
gtatgaaagg ttctagtatt tctcaaacat ctgggtttaa taagtatcat gaattatata 38160
atatgttaaa agagcaatta caaagtgtac atgacaatac cgataatgtt aatggtactg 38220
gtggcggagg aatccggtta gattttttag attatactaa cgaacattat tataagtgtg 38280
aactaagtcc agatggattc cagtttactc aaagtaataa taacccatta tcttatttct 38340
atagtataaa tttagtcgta gttggcaatg ctagtgcgcc tagttattca gaaacaagtt 38400
ggattgttct aggaaatata aaaccggccc tatctaaaaa agaattatcc aagtattcaa 38460
ttgtatctaa aagttctcag tatagtaagg atttatatgc tagtggaaat catagcaatt 38520
atgttagtgt cattggttca aaagttagaa cctctgcatt aagtaagatt gctaaggata 38580
ttgaaaataa tatgctatct aggggggcag atggtatgcg ctcacctatt ataaattata 38640
aagataatgg tccagcctat tcatttcaga aacctttatc aagttctaag atagctaatt 38700
tatataaaaa tgtttataca ggaataaata aaaaagttca cattgtagtt ggaaataaaa 38760
atgttatgga tattaacata tcatctgata attcctctgc atggaatgct tattgggatt 38820
tatatacaag aagtgctgga aaattaaaag caggtactaa aaatggtatc atagactatg 38880
gacaaggttc tgctaatgat gccaatagtg aattgcccga ctatgatagc aataaggcgc 38940
atgagaccct gtatggttca acagtagcaa acttagattt aacttattat ggaaataatg 39000
aaaaaatata taagcagtta tttggtaatg ttttacaagg atttaatgct gatgagtatt 39060
ctaatgcggc agtggctttt aaaggggaca tccgttcaac tattcttaac tacggtcaga 39120
ttgacgctaa agatgcaagt acaactttgc caccctacca agtaaatcaa gttttttctg 39180
aattatatag tcagagagta gacaatttgg actatggtaa gtatcaaact atgagtgaat 39240
tatttactaa gatgcgcggt ggaactataa ataactactt tggagatgac tatagtgaac 39300
aagagtcatc tggtagttta gggttagata aggcttctaa tatttattct gtattatttg 39360
gacaaaattt gagtgagttt gattacagca aatatataaa tttagataat agttcagata 39420
ctatgaacga tactgatatt tttaattcag ttggttacag ccaaatatca actagtttta 39480
ctaatagtag ttatgggact ataaataatt atggtcagaa tcagcctagt gattataata 39540
ttgactctag ctataattta gatgcagtta agaaacaaat tgtaactagt ttaactgata 39600
caacttggga cacggcaact tatgggactg atagtaaaaa tattagtgga ttgtatcctt 39660
taaacacaag ttctaatgat gatacaaatt cagtagatac aagtgcacct gtagaagaat 39720
acgttaaccc taatgtatca gatagcgcgg tattatatgc ttacaatgaa atatcaaaca 39780
ttttaaaaat ataggtgggt gattgaatgg cagtaacttt accccttcca gctatttact 39840
actttcttaa tttaaaagta gattctaatc ataatttaat tattcctgat aatggatata 39900
atgattttaa tacaacggag ggaaaataca catttaatgt tagtggttct acaatatatg 39960
tattaaacaa tattattaag aatgctgatt acaattcatt ttacttgaat gagcagtcaa 40020
ttatctcgtt agtagctgat acagatttag ctaatacaca tacaggtata aatgaattgc 40080
ttagattagt tgttttagat tcttgggtgc ttaattatat tttattggaa gaccaaacag 40140
ttattcaata tataacagtt gatgacttag agaatactcg tatgaatata aaatttttat 40200
gtacattctt tggcgggtat cggaaatata gattcttgat tgaatattta cgttctttgg 40260
aaatatctat tggatatgca gagaataaga taaatttaat tttaaataat agtgatttac 40320
gatatgcaat agatgggggg tagtgattaa aattggctat ctatagagaa catgtagtag 40380
caaagggaga aaatattcag ctaatttcaa ctaaggagtt acaagatact tctaggtggc 40440
aagagatagt agaattaaat gacctaagat acccttatat tgttaagaca aattcagaaa 40500
agactcagga ttatcagcat ctagttactt atggagatgt aataaagcta cctgagatta 40560
ataattttta taatattgat ttaaatactt tagatgataa gggtaaggaa atcgtttatg 40620
atatgtctat gggtatggac ataagcctag ctgtgaacaa caaagcaggt ttagatgata 40680
atattgctta tttgtatcct agtcaggata aaacggactt agctacagct acgggtattg 40740
ataatttaaa ggaatcaatt cagagaagat tattaacgag aaaaggttct ttaatgtatc 40800
atccagacta tggaacaact atgttagata tggttggtga aaaactaaat cctactttga 40860
ttgatgattt aaaaatagaa atcgttagaa caataaaaac ggataaacgg gtagacaaat 40920
gtgaaatatt agaaatatct gtaccggatg gaaaaacatt cttatgtgca gtatcaatta 40980
ctcctatagg tatgagcgaa gcatttaata tgtttattca aaatgcaaat ggtggaagag 41040
taagggtaga atagaaaggg ggaaacagtt tggctagtca ttttagattt aaaaaagcta 41100
gtgaggttct gtcttcaatg acagattata ttttaactca cacaaataaa attaatgatt 41160
ttacagaagg ctcagttatt cagacgttgc tagaatcatt ttctactgaa atagaaatgt 41220
attattattt aaatgttgaa aatattaagc tgggtatttg gaatagtata tacacctcct 41280
ttggattctc acggaagcct gaattaaagg catatggtac agttaatata gtatttaaca 41340
atgagactag tggcccaact gtaatttcta aaggaactaa gtttacaagc agtaatagtt 41400
tatatccaca agtctttgaa acgttggatg aatttaatat tgattcaggt actacagaaa 41460
caactataac ggtatattgt acccaagggg gagaatatgg taatgttcct gcgggtgtta 41520
ttgatactgt cggaaatttg gctaatatta gctctgtata caacgatgaa gcgtttcaga 41580
caggtagaga ggaagaaagc ctagaagacg ttagaagacg ttttagaggg tttatacaag 41640
ctatccaaag aggtactgtt caggccatcc agtttggggc aatgaacgtc cctaatgttg 41700
attctgctta tgtagtagat tctccgggaa ttgtcaatgt ttatgtgaat gatgctaatg 41760
gagatttacc agatgaactt agaatagcag ttcaaaatga aatgtattat tggtcatctg 41820
taggtattcc aattactatt ttgcctattc ataaaacaat ggttgattta gatattattg 41880
tagatgtccc taatccggct ttaaaaaatg atgctttgct taatgaaatt ggagttaagc 41940
tatcaagata tattaataag tttaaagcag gacaacatct ttatacaaac gacttagttc 42000
aaaaagttat ggatataagt gatgatggta taaaggatgc ccaagttaat gttaagatta 42060
atccagatgc ggctattagg ggtgacttag cagtcagtga tttaaattct attataatta 42120
atagtcattt atatccacac aagatatatg aaccctctga tagaactgtt gatgagaatt 42180
atattgtatc taacccagag gatttagata atggtcagta tgcaaattta ccagatggtg 42240
aggggggtaa tagtacaact agtacaacga cctcaacaac tttaaacaat gaaaataatt 42300
tagaatctaa tacttctgat gcaaattatt ctaataagaa tacaattgct aatttcgtac 42360
taacgactcc tgataataat ggtattgcag ataatcctta ttttgttaat ccactaacag 42420
tagccagtga taattcaagc aattcttttg attatttgat gtctgataag acaaccattg 42480
gacaagtaac tgatactacg ggaacttcta ttaattctta tagaactaag aatgtggatg 42540
gctctaaatt aagtattgca tatacatcag atgttaatgt gatgacttta gattacacac 42600
catatgattc agaaacatca agctatggtc ctgtagacac aaaagttgtt aatttaggtg 42660
atgatattat atttcatgac tatgaagtat ctgtatcttc tagtttaatt tatataagag 42720
atactattaa taacaaccgt acaagcttta gcaaaaaaac taatacgctc agtcatacca 42780
attctgataa ttatgtaaca acaattgttt ataatcctag tgataacact aagaaatata 42840
cggcaacaac tcaggtagat agtcaggtta aaacaattta tgtctacgat aatgaagctg 42900
tagttgcaag cagtaaaact atcgttatta gcttatctgg taaccgtaca gagacttctt 42960
ttgatggtaa aggaaatact acaatgacta acacttatgg gccagatgga gttttaatta 43020
cttctgttga tggtaatggt cagagcttaa ttacaactac gacaactaca atgtaccctt 43080
atacgacaag tacaacaacg gaacctgcaa gcacaacgac aactacaaca actactacta 43140
tttatccatt tgagaaacct gctcctgtta gtggtagtga tgcaaccgga gatgggtatt 43200
tacccgtatt tggagagtat ttaacgagtt ataatgaatt attaaaagca ggaaatatta 43260
gtattaactt tgaagaaggt gattaatgta tggcaagtat taaagacttt ttacaccccc 43320
tatggagaga ttctgtagat aaggattttc ctgatagcaa tgtcgaattt aataaaacga 43380
ttttagattc catcgatgaa aaactatcca tgatagaaga tgaaacctta aagtcaaaag 43440
aacagatgtt tattaaaaca gctaaagatg agtggctgga ctattggggt agttggtttg 43500
ggttaaagcg taagaataat caaacggatg atagctatcg gaatgctatg cttaatcatg 43560
ttaaacatcc cagaaatact aagcctgcat taagggaagc aattgctaat tttttaggaa 43620
ctagcatttc ttctgtacac atatatgaac cttggaaaga tatatttatt ttaaatgact 43680
ctcgactaaa tagtgataaa tatttccaga gtgattacta ccaatatgga attattgata 43740
ttgagattag tagaccattt aatgaagatg ttattgatgt aattaattgg tttagacctg 43800
ccggtgttat ttgggtgcta acctattccc ccggaaacga ttctaatgct gatatttggg 43860
aaatgtcacc tactaactta tccgtagcac aagaattatt aactattttt gattactctg 43920
gttggtatag tcgcttaaat gagacgctga ctttgggaac tacagataaa acatttggca 43980
gtttgccttt tattttaaat gattctagta caaattctaa tggactgctg atgggtaagg 44040
gattaaattt cggtgtaggc tactataact ctttgggtta tttgaagtct ttaatttcac 44100
ctactaattt agataatcct atgtcatttg aagataagat tataaataat ccttatgatg 44160
acctagcaaa actatcatta gatagcggta attccgttga ctttattgtt agtcgagata 44220
acagcttata taatttatta aagggaactc gtaagttttt gggttggtcc tttaaaaatg 44280
gggtatcttt agaatctgat aagctaaata ctcgttctat tgctaagatg acgcgtattg 44340
actcatcaat tgaatcgaaa cagtatatta aactaactgt aggggagacc tatgtattat 44400
ccgtaagtgc taaatcagaa gctattagta atagagttaa tttattgtat gatttagata 44460
cggcacataa gaatttatta ttaacggacc aattaactaa gaactttaga acttatactg 44520
ttaagttcac gtatacgggt tctcctatca ctttaaactc cttacaccta tcaggggata 44580
taacttctag cggagacgtt tacgtgtcta gcattatgct tagaccagcc atagtatctt 44640
catcaaactg ggatttaacc cttcctgatt ggactgatag tgttagtgac tttggtagtt 44700
cgtttgatag aaatatgtca tatgtgtatg gttctttgaa cattagaaag tttttcttcg 44760
acaatattca aagtgagggt actgttatta gtaagttagg agttaaggca acttctgacg 44820
atgttaataa atacattaat agttatctgg aaaataagaa gataactgct aagtatcatt 44880
cagacattac tgataatgtt catgcacaat tgttattcta caatttcaag ctaggaactt 44940
gggtaggata ccaagatgat aatctttctg accataaagt tgatattaat ataaatgcga 45000
atagtttgta cccttatatg aatgaatcag gttcgatgtt tattgcagtt agtttaacta 45060
ctttgaatac accttatacc tttaatttag actatattgg tattaatttg gataagaaat 45120
tggattataa aactgcttat aatatctatt ctgatgatga tttaggtgat gaacaggaat 45180
ttacctatta taatgaattg gatggtagta aagacacttc tgatatgtat acgagatacc 45240
agaaacgtta tccaattaga tatattagaa atattattgg taaagttagg tattataaat 45300
acagagagaa tgttttaaac ccagattttc ttttaaattc aaagtccgtt ttaaatagta 45360
attcagtgct gggtgatttt aattataata atattgttgg aggttcagac tctgataaat 45420
atactagtta taaggttatc cctagagaaa acgataatgg taataaattg ccggtttatt 45480
cattttctgt attaggtgct aaatctttag atagtttgca taagaattta ctaggaaatc 45540
ttttatctgg tggcatcttt tatgattatc taagtaataa ctggaatatt tctaatggag 45600
tagtagtctc aaaggataag ttagaaagtt cagacaagct aactagcagt cgtttatatt 45660
ctagttctac tgatggtgtt attagtatga ctactgatac aacgttctca gaggagaatt 45720
ataggtttac ttttgatgct agaaataatg aatcaaatgt tagaaattac gttgttaata 45780
tttatttaat aagtaataat tactccgtat tatctatgag taaaactttc cctataagag 45840
cggtaaaggg tagctacaag ctaacttttg atactaacaa agtatttcca gaccagatta 45900
aaatagaaat gtacccagaa gatagaaaag ggtttgattt aacactgggt aatactcgat 45960
tatctttaga tacacatgca accttagatg gaaaacctat agataaccta cctgatatta 46020
ttccttatag tgatgaccca gaagatagtt cagtaactta tgatgatatt cagatagata 46080
attcagatta tgctatgcgg tttgacacta tttatagtta tgattatgca gatataattt 46140
ctggactaag tgaattatca aaatccatta gtaaggaaaa cttggcatct tcttatgaat 46200
ttaaggatgc cttagatagt ttaataactt atattggttc tatgggagtt tctaatttag 46260
gtgatactca taccttatta gttgacctag gtaaagttca tacagatgta gatagtatct 46320
tagttcacca tggttcaggt agtgatgact tagcagaata tgatagtatt gtgcaaacat 46380
ctttagatgg aattcattgg aagacatggt ataataattt tgataaggat ttaggggaac 46440
ttgatgaacg ttatcgtgaa cctactgata gtcctaagtc tataaatcta ttaccataca 46500
atgtaatttc ttcttctgtt gactatggta aatcttatga aaaagtcatg tcggatagat 46560
atggtatagg tatggaagaa tatactggtt tatcttatta cgtggatgaa ctacgttttc 46620
ctgcttatgg gttacttgat tatgtatttg gggattcatt gccggatgat gtagttaagt 46680
tatcaacagg tgatagtgtt gttaataata agtatgtaga tattaattat atgggtgctg 46740
taggtaatgg taaattattt gttccatctg acttggcaaa taatgcaact actacaacca 46800
cgacaactac gactacagtt aacccaaata cgaccactac tacgacaact gtagctcctg 46860
attacggaga tgacggaata gtatttaatg gaactactta tttaaattct gatagtattg 46920
ttctggatgg gagcaagaag tatccagtaa atcctaatag tacaaccacg acaactacaa 46980
ctacgagcac cacaacatca actactacaa ttaagcctat agatacaaaa tttgaatttc 47040
ttctttcaga tgataactct aagcttaatt ctaacaggtt attggttgat ggtagtttgt 47100
actatgttga acctgaaccg ggagaccccg ataatcataa taatggagat gtcccaattg 47160
ttccaacagc aattaaggac caagtaatta taggcgttga tttatttaaa ctggtaagag 47220
ataactatgg ttatgagcta aaagttttag gaattaatga tgatagcaat ttaagagaat 47280
tcttactaaa tactttatta ggaactagat tagttaataa ggtattatct attaatttga 47340
gtgctaagac aacaggtatt aatctgaccc tatctgcatg gagtaatttg aaagatggat 47400
attggactaa tacagaaaat ggtgttttag ataactatag ttcagagtta tcaatgacgt 47460
ttaataaatt agataactat ttaagcgctg atggaaaatt gtacttctta gtggctagtg 47520
ataattattc cggtaataaa tacacaatag ccataaatga attcaaggcc gtacagctga 47580
taactttcaa tggtattgat gactataatc atggaattta tccacattat aattatgcga 47640
tgcaggatag ttatattcat ggcagaggtg cagttaacga taaggtatta agtagtattc 47700
caattagcaa taaaactatt ggtagaaaag tacgtgttag ctttaatgtc tattccgagg 47760
gttctggtgg aatcttatac gtaggtaatg aatcattagg agttactact gagggcatag 47820
ttttagaaca aggtagtcag catgtatcat ttattatgaa cctaggaaat aataatcaga 47880
atattgatta cagtcaggaa cataaattat atgctgattt taaagaggag agctaccaaa 47940
atattcttag taattatgcc agcaaggttt ccttgtattc agatatgtta cgaacaacaa 48000
ataacgtaga tgatacagaa accgttacta atgggttgct gactaatgat agtgattcaa 48060
agttgaattc agataaggtt gttagcgatg gttctgatgc agacccaatt attacaacta 48120
cgactacaac gactactact tcaaccacaa ctattccacc aatcgttgtt gagaatgaat 48180
tagtatatcg taaattattt gaaaatggct tgaagtataa agacctatta atctataatc 48240
aagataagtc tacaagtagt tatgggcttg atattacatt atctaagtgt aattatcggg 48300
taatgataag tccacttaaa gtagaacttg gtgaaataga gactccttat accaaaccaa 48360
tagaaataaa ttaatggcag ggcaatggct ctgctatttt attttgcata ataaaaaata 48420
gtataatagt tgtaaagaga ctattaagct tatattaata accagaatac gatataaaac 48480
agaatatgga ggtggttttt tggctataga aactatttca tcacatgtta tggttgctaa 48540
aagctttaaa aatgacttac ctaatctttg gttatctatt ggtaaaacaa ctccttgggt 48600
ggatgaagat attccaccag cagaagatat gtttactact accttagatg aagttattgg 48660
atttaaaaaa ttcgatacag cacaattagt agttccggta tcatctttaa ataatattgt 48720
tccagataag actgtttctt ataaagcaga ggattgggca tttgttacag atgatgatgc 48780
aatgaaatta ggtgctaggt acgtttattt ggaagcaaca attggaccgg gggagttacc 48840
ttatgcagtt tatagacaga taggtattta taaaggatta gctcctcagg atagattttt 48900
agataagaca gcattaacac ctaatcagat agaagatgct ggggtattgt tggggtatga 48960
caatagatta tttcaaagat actcagataa tgtaaaacta atcgaaaaga tagttttaaa 49020
attttaaggg ggtatagagt ttgacaacat ttaacgattc agcttcacca tataataatt 49080
tatatgatat taaaaaccgt tggtcaaagg ttgaatttgc accaagtaga cctttgtttc 49140
aatcagaatt aaatgaacta caatcaattt ctaatgacca gattgcgatg ttaggtaatt 49200
ctgtatttaa agaaggtgca gttattactg gtatgggact agttccacaa ggaactgtaa 49260
ccccaactga cccagacacg attgtaggta atcctaactt attgacctat gcaactatta 49320
gctcatataa ttctaggatt gacacttcat tctataagat tacgggtaga attggtgtta 49380
cttctactgc ttctttagca actagttatc ccggaattca gttatcagta tctggtgtat 49440
caggtggaac ggctacactt agctttagta ttaagcgtga ttcaggtact ttgtataagt 49500
tagctggtat ctttgataag tcattgacgg tatcagatta ttcaattgat ggtaatacga 49560
ttactactgg gtttgacgat gtaacgacta gtacattagt tacagtagat aataaacaga 49620
ttaacttgtc tgatggtaat agtcataagg ttacagtcac ttttgaagga ttaacttctg 49680
gaacttatcc tattacgtta gaagccaatc cgggatatag cgctttgaat gaagggcaag 49740
ttaacttcac tttagacaat atcaagattg aagaggggga cactgcaact gcttggaagt 49800
tagcagaagt agataaagac ttatctacag atactgaccg aactaagatt tatcgggtac 49860
tagaagggta cgtttatatc aacggtatgg tacgtaggtt cgaacaacag gatattaata 49920
ttactggtgt aggtaatgaa accattggta tcaacattaa cgaagatatt gttactagtg 49980
atgatgataa cagattgcta gattctactt cgggagcagt ttctcagtgg aagagaggtt 50040
cagatagact tcattatacg cttagtttga cttataacga ccctaatgca actaccctat 50100
ataagttatc taatgggtca ttaagcactg atacaacaga ttctacagct tcatctctta 50160
gtgatttatt ggctcgtaga actaatgacc aatctggttc ttacagggta tccggttttg 50220
atatgagttc taaggcagat actcaggatt cttctatggt agacattgtt attgatgctg 50280
gtaatgccta tgtattaggc tatcaggtta agaccggtgt tcctactgta ttaaaagtac 50340
ctaagtcagt cggtacagca gatgcaccag atgaagtatt catttactct gagtctcgac 50400
cagataatgg aaagctttct aatcaaccag ttaagtctgt taatcaggta tctggtaacg 50460
tacaagttac tgatgaacct attaatagag gagcaactat ctcggttgaa gatactttag 50520
ctaatcccgc ttatgagatt gataaggtat atgccaaggg tagtgaaagt tctataacaa 50580
cttatgtgca gggaactgac ttcacaatgg atggtcaagg aaagattaag tggggagcta 50640
cagagagtgc taaagcacct gcggcgggaa ctacttacta tgtttcctat aagtaccaag 50700
caatctttaa aaatggaaca gattatcaac tagatattgc aggtgatgaa gagcgtcaag 50760
ttacaatggt tacattctta ggaatgaacg gattaaaacc agttgaaggt tctcaggttc 50820
atgtttctta tacgtatttc cttgctcgaa ttgatgttgt gactgttgat aagactggta 50880
agtttggagt tgtaaaaggc cagccagata agctttctag tgcaatgcca cctttacaag 50940
ttgacccatt aacattacaa ttaggatata ttactgtatt ccctaatagt gataaagcga 51000
ttactcagtt atctacaatc actagattac cattttctag tttacaggaa ctaagtaatc 51060
gggtaaggag cttggagtac aattcaagta tttctgcggc aagggattca gctacaagta 51120
atcaaaaccc gcttaattta cagggggcag tttatgatga ctttacgggg gttgctaatg 51180
gtgatattgg caacaaggaa tttactgctt cttatttgtt tagtgatggt gcaattacag 51240
tccctacaaa agcatctact ggtattaagc cagatgtgtt agaagtagca tcaagtttgc 51300
ataagttttc gcatacagtt actacaccat ttacagaaac acctatggtt tctcaattat 51360
tagcaacagg tgtagttaat attaataagt accaagtatt taatgttatg ggtactttgg 51420
aaattacacc tgaaattgat acttggacgg aagataatac ttctactgtt tacgtagatg 51480
gtgccgctac aactctcagt tttggtcgtt ggtgggcata tggaacatgg actgatgcta 51540
atggtcatac tacaggtggt gaccattata cgggacaaga tgcttataca gagatgcaag 51600
gtattgtgac aagtgatgga aatgatttaa tcaattatag aaattggtct aatacttctg 51660
gaacacaaac aaaaaattta gggactcaaa cagttgattc tgctattgag tatattcgtc 51720
agcgtgaagt tacctttagt gctaagaact tattaccatt tacagataat atgaagatga 51780
cttttgatgg acaagcagta gatattacgc ctgctgatgg atatgcttct ggtactgata 51840
aaggtagtat taaaatagat ggggctggta cagctaaagg tagctttact attcctgagg 51900
gtattcgtac gggtgttcgt gaagttaagc tcgcaggtac aaatggtagt gctattacca 51960
cttatacagc acagggaacg atgcatacag ctacaacaac cattgaacgc cgacatgtaa 52020
cagttaattt ctatgacccc ttagcacaaa gcttcgcagt aactcaggat ggtattttaa 52080
cctccttaaa cttgtggttc aattcaaagc catctagtga tgatattgca aatatttctc 52140
atcgttcaga tgtagttgtt caattacgtg aaatgggaga ccaaggttat cctagtcgta 52200
caattgtttc tgagactacg ttaacgcccg accaaattaa tacttctaca gatgcatctg 52260
tagtaactaa tgttccttta gcagacccag tttctgttaa ggcaggtgaa tcttatgcgt 52320
tagttgttat ttcagattct gataaataca atatgtatgt atctactact gggcaatcac 52380
gtattggtgg aacagaagcc gctgtaggcc aagcttatgt agagggtact ctatttacca 52440
gtgccggttc tcaaacatgg actgctgacc aaaatagtga ccttaagttt gaagttaata 52500
tgggtaagtt ctctgataca ggtactgttg attttgatac tatctatccg ggaaaagaag 52560
tctacaccga tggtttaggt aatccaattc tggataaaga cggtaaagaa attacaatga 52620
ctattgacca acttgtttta ttggcagata gcttgactcc tcagaatacg ggtattgatt 52680
ggcagattaa gattgttact actgaccaac cagacaacgt aacggttaat gatgttgatt 52740
ggcaaccact taacgttgct tctgaaattg aattaattaa ggcggctcgt gagattaagt 52800
ttagagcaat ctttaaggct tctagtacct tgtcaccaat tcttgctttg gatagtttat 52860
ctctagcggt attcttgacg gagacatcag gaacttatat ctctaagaat tatgatatgt 52920
ccgcaacacc ctttaatcac attcggttgc aatatgatgg ttataccccc ggaagttcta 52980
ctattaagcc ttattatagt acagatgcag gtaaaacttg gaaagagttt accaacgcta 53040
gaactaagac ggttagttta gatagacact tcactaggta ttactatgat ttacagcttt 53100
atgatttagc tggtggtgac cataccgttg cttctaattt taaggttaag ttagacatga 53160
gtgcacaaag ctcattccag cgtcctcaaa ttaaggcaat gaatgcttct gttactaaac 53220
aggacggata tgattcaggt actgatgatt accaaaaacc ttaatgataa gaatgataag 53280
caggattaat ttcctgctta ttgtacataa tagagttaaa ttaacattga aaggtggttt 53340
tattaagtgg aagataaaga ttttttaaat actttggaaa attggaataa taaagttcta 53400
aatgaacacg acttaattgc agactctagg gagttaatta atcaattaaa tacagctttc 53460
ccttttttag catctaggtc tctagttgtt aataatgact tagtaagcag tacaggggat 53520
tggaacgact tacaaggaaa tacggtatac gcatataagt ccttaaatgg taaaaatgca 53580
ccagatagtc agaaattagg gacaaattat gggattgtct tgactttaca aactcaggat 53640
aggacgctaa ctaatcaatt agtcattcct acgggtagca ctgaactatc tttagcttat 53700
agaagtaaca tggggacttt agtaggaagt acatggtctt atttaactcc tagtgaatta 53760
tattctaatt tacttaagag cgataatgta tttactggtg ttaataagta tatgacaccg 53820
ccacaagata aagatggaaa ttcctttatt actgcacaaa atgttagtca gttagaccca 53880
acaattgttc atggtaaaga cttaacaggg gtagcaaatt tgttatctgt taagaactct 53940
atttcaggtt atttaactag tgaaggaaca ttacagttaa atggtttgtt atatagtgaa 54000
aagactagtg actatattaa ggttgataat caagacccct ataatttaaa tatttatttg 54060
actgttccta atggtaatgc tagttgggta gcattatcct tatttgataa agataagaag 54120
ttcattggta ggattgttcc tacagcagag aaccaagatg gggatacttt tgttaatgca 54180
acgtattggt tattaccaaa aggtgataca agtaaagttc cgacttataa ttttactgat 54240
gaaactcaat atgtgagaat tagttggaga aattataatg atgcaaaggt tatgttaact 54300
cgtgggtact atccacaaga ttatgtacct aatttagatg atttagcaga tgacaatact 54360
ttagtgcata aatcagatgt tttaggtggt aggaactatt taactaatac ggataatcca 54420
actacgagta accctatcca gttatttgga gaagtagccg acattgatgg taatgttgat 54480
tactctactg ggagagttaa attaactacg gcaacctcag gagaaacgta ctatcgcttc 54540
aatggggcta atagaagaat gccattacaa gcagggcaaa catataccct tagttataat 54600
atgtctggta ctgctggtat atacttggct actcgtatta tttatgcaga ggatactgtt 54660
ccaacgtggg gtgatttact actttcttac cacacatgta caactaaatc tatgaattat 54720
aaggatacct ttaccgttcc agatactgcc ttgtcactga ttgtttctgt tcagatatat 54780
gcggatacta acaaaaatag cgacaatact ggcacaaatt atgttgaatt ttcaaatatt 54840
atgctggaaa agggtgaagt gcaacatgac tgggtacctt caccaaatga ttttccctct 54900
gctgtagacc ctagtgtagc acaaggtaaa gtattaacgg ccaacgatga tatactggcc 54960
ctagacacag gaacttacgg ggtaagagta acagcaccta agaattatcc cacatctaca 55020
ccatatggaa tcgtagtggt caaacagatt agtgaacaga gcaagatggt agaagtatta 55080
gatacttcta acaaacactt agttaatatt tatagcggta gccctatcac atggtctggg 55140
tgggaagttc ctaactcaga tacaatggct actaaatctg atgttcaggc agcagttaat 55200
acagcaacta ctgacatgat gaaaactact gattgggtat atcattcaag tgcagatgac 55260
gctgaaactg cttcgggtaa tgataattta ttccattatt cagatgatta aagaacggag 55320
gtaattttat tgagcatata taaaaagaac ccttctggtc aggaagaaga aattagttct 55380
atctatcgta aaaatcctaa taccggtgaa gttacagaaa ttacttccat ttataagggc 55440
ggaaagctaa tttatacagt aaacaagcct ttatgggaat ctggtacgtt taattatatt 55500
cttgaaaaac cccaacttag ttcagataat accctgatta gtcataattt taatacagat 55560
aaaaacgttc ctgcgggttt agctagtggc ataaatacaa tttatacagg ccaaaacgat 55620
aaaacattgg gcggaacatc acaaaaattc tttccgagca cttataactt tgtaggtaat 55680
cgttatgtaa ctaaagacaa taaatatata tatgctatta gttttacggg ttctaatatt 55740
agtttgtata agatgtcaac tgtagataat tcagttaaga attctagttt atttatatca 55800
aataatattt ttaatgttta taatactgga tggacacaat ttccaacggc agattctcct 55860
tctggtttta aaacagttaa aacgcctatg ttattatatt ttgtacttac aacaaaaggt 55920
aattctgtag ctagaatggc taatcctgat ggttttgtag agagtggcga ttttcttaaa 55980
gcaaacggtt ctctaaggcc aacattgggt aatcctaata taatccctgt agacaagttt 56040
aagttagcta tagacagtag tgattatgga cagttaagtg gagttcatgg ggggattatc 56100
ggcattattg gcaagagtaa tattattgat gatagtgcta atagttctaa ttatgggaat 56160
gctatttact taactaatgg tgctaaaaca ctagttagta atttagataa caatacaact 56220
aatgcagtag caaacattaa agttacttta gatgtaaaca tgggttctga tagttatagt 56280
gggttgaatc ctatccttaa tccgggaaat gacgttccta tttatataga tgctagtaat 56340
ttaactccct tgggatatta tgagttaccg ggagattctt caaattctat tgaagaacat 56400
tattcctttg caatgccagt gagcttagat aaaaatttcg tggaatatga taaaattaat 56460
aataacattg ctattgttga tattgtacat tatgttagca atggtaattc atccagctct 56520
tctggtgctg atttatgggc tataggtgtg gttactagtg ataagtcttt cctaaaaaaa 56580
gaatttggta aagttaatgc aattgcagaa gattatagta attacgataa agaactagta 56640
gtacctacag atggtactag tattaatagt cagacagcat cttttgggaa tactagtata 56700
tcttctaagt attatgttcc taaaaatggt tctatttatg catccataaa agatgtatca 56760
acagatacaa accaagttaa aaaatttaga cttaatggta aagattctaa ttattgggat 56820
tgtactgttg atgggtatac tggggcacaa gtattaggag aagatggtga tttatctgct 56880
gatggaagat ttgttacaag tcctaatata tatatcccta ataaatctat tagagttaaa 56940
tatgtaggat atggagcaat ttctggattt tctaattaca atgttttttg cttttatgat 57000
aaaaatggta acttagttaa ttatcagaaa gtatatggct taggactata ttctgtagta 57060
gatattccac aaggagcttc tatacttaga atttctgtta tgatacgagg ggatatgcca 57120
gcatcttcaa ttcctaagac agtaataact tttgataaca atgttattta tcagataccc 57180
aaaggttatt ctgttaaaga tatggttaaa tacaagcata atttatatat gacagtaacg 57240
aatgatgatt ctggctgggg caagaattta acttcaccaa cagcaggttc taaaattttg 57300
tcctctggtg tggataactc agggaattta tattcattta gaactgatgg ctcaggagca 57360
aataattttt attactggaa tacttttaca agtaaagacg gttcacagat gttggtagct 57420
tcaaaccaac actacccggg gggtaataat ttaagtttaa atccatggga taatcaatta 57480
atatgggata gttttaatgc taagatgtta tttgtaggta ataccggacc aatatacagt 57540
ataacttctc ctaactcatc aggaagtctt ggaggggtaa ctactgctag ctctacgaat 57600
gttaattata ataattatac taatggatac tatccgggat tttgtgttga taactctggt 57660
tcagttatta tgccaaattc ttattataat aaaacaggta ctagtaccat tctaggaact 57720
ttaactaaat attcagtatc tggtacaacg tatacaccag agtggagtgc tacaccaacg 57780
cacttaactg ctactcaggg aattattgac agcaaaatag ataaatctta tattatttgg 57840
gacggtaatg ctaagatagc caaaattgat gctgatggaa atattaaatt tcaagggaat 57900
tatgctttta ctaacgacca aggaaataac actatgcaaa atagaaatca accaactcaa 57960
tttactatct tacctaatgg taatatttta ggtgttagag ttaattatac tggattagct 58020
aatggggtag gaagtgtttc tcaacctacg actttatttg tatctgttat tgataaagat 58080
aacggaaatg ttttatctgc tagtagtatt attttaacag gagatttaag cggtgctact 58140
aatcgtgttt tattagctaa tgctggatat gtagctgtgg caggaactgc atatagttct 58200
gttaaaatag ttgttaataa ggaagataat agtttaaatt tgaccttttg gaataacaca 58260
ataagctcag gctctgctgg aacaacatct gatgttaggc ccggtattga tagtttatca 58320
gcaagtgata ctgcaatata tgcaggtacg gattcaggac ttgtatttag atataattta 58380
gaggatgaat tttcctataa atgggtatcg catagcatga cggatgttac ctcaaatgtt 58440
ttagtaacgg cgcaggaaaa ttatatttat gtgacaggtg gaaatactac tagccatatg 58500
tctgttatta agatgttgcc taatgggaat ctatatgaat cttatgtaaa agctatgaag 58560
gtttaaattt atattaatag gagtaagagt tgttgacata aattaagtta ataactaaaa 58620
agaaaggaag ttttatagat gtttatttat atcacatttg atgcggatgg ttggattacc 58680
gactatacca aggaaaatag agacgggtat actcgtgctt atgtactcga ttcttggtat 58740
tctgattttt tgagtaattc agacaagttt agatatgatt caacgcgtca agttatcgaa 58800
agtcctaaca acctacctaa gaaatctatt aaagaaattc aggattcttt taataatact 58860
ttaactcagg ttgatacttt aaataaaact ttaggggaaa cacaaaagtc tttggaacaa 58920
ttgcaaacaa ataatgagac tagtgatgca gcgaatagtc aagttacaat gagtttaatt 58980
tctggacaat tatctctatc tgatagtatg aatgacatta agcagatgtt gacaacatta 59040
acagctaccg aaaaagaaac tgctaccgat acagatacga caaataaata agggggagtt 59100
ttataatgga tgaattgcat agagcaatgg taaatacagt tatggtggca tataagtata 59160
agattttaga taatgcttat gtagcaagta aggttaatca tggtttgtat gaagaagatt 59220
ttaaggaaat tacaggtctt gattataatg aatacatggg gattaccacc acaaccactt 59280
caacgactac ggaaaaacca actacaactt caacgacaac aacgagtagc accacggaga 59340
agccaaccac aacatcaaca acgagtacca gcactacttc tacgacttct actacaacga 59400
agccaactac gacaacgact acgagtacaa gtaccagtaa gccaactact acaactacaa 59460
ctagtacaac tacagaagat aattctagtg acactgatta tggcgatagt aattcagaat 59520
catctaaata ataaatatta taaagagaaa ttatatttct ctttatctac atagaatctt 59580
aaaagaaagt aggtttttaa atggcaacta atttagagtc acaaatgcaa aattataata 59640
gcgaaaactt agatgataac tctaaagtct atgatacaaa agacttgtta aaccagttga 59700
ctaatatatt tcctaattta tataaaggaa cactgacagt atccagtcaa cgagtgagtt 59760
taaatacaga ctgggaaact ttaaaggtaa atcagattta tcgtgttgaa gacatttcag 59820
gggttaattc accagataag aataaactgg atggtaatac agcgggaact ttatttgttt 59880
atggagataa aaatttagga actaatttta aaatatttgt gtctggctca atgattgtct 59940
atagacaaca atctgatagt cagtattatt atttaggcaa ggattatgta actaatactg 60000
atttggatac agcaataaaa accttacagg ataaacttac tcagttattg aatgctaaag 60060
cagatgacga tagtgtagtt catttagacg atttacttgg cggtgctaat ttagttctaa 60120
atagtaagtt tgataacaat atggataatt ggcggacttt tggtacttct acaggggctt 60180
ctattgattt tagagtaggg gataaagact gggataatcg tgctaataat ctggttcaca 60240
ttactaaacc taatacagca ggtcaatatg gggttgcaca agataatgtt tcagtagcac 60300
caaacacaga gtatgtattg tctgcgtata gaacaggatt agggagaatt tatttacaaa 60360
atggtaatgg aactactgac ccttaccaac agacgattac caaagagggt gcaggttttg 60420
taacccatag atttacaacg ggtaatacaa gaaccacaaa tatttatatt ggctttggtg 60480
aaagagacac aggtcaatta ttcgtatctc tagtaaagct agaaaagggt gtaacttata 60540
gtgattggtc acctgcacca gaagatatta ttgctagtaa taaaacggtt gagttagcta 60600
atggtattga tatagatact gtagttaaaa gtggtatata tggatataca agtaataatc 60660
catcaggagc taagcatggt ccagatggac atgatagttg gtttttacta gaagtaaatg 60720
acttgatggg tgatagcgta aatggtgtac aaaaatacta tgacactaac gatggaactg 60780
gatttattag aatgtggaaa caggataatg gaaatagatt attcacgcca tggacaccta 60840
atgttgatat tggtatagaa tcagatggag ctgatttaaa caatagttta caggtgggga 60900
ctttctttag tgctactaaa gtaactaatg ggcccggatt ttataaccaa ggttatgggg 60960
atgttatggt tacgtggacg gttactaaag tttctaatgg tactacccaa gtatataatc 61020
agaatgcata taatcgcaat ggggagtgtg ctacacgtaa ttttgtttcc ggtgcaggat 61080
ggggtagttg gaaaatatta tcaacagacc caagcaagcc tatggatttt ccgggtggaa 61140
taacttctgg gggtgtcgat gtcgcaaccg cggctgattt aaaaagcgtt gcagacaaag 61200
cttggtatca attagacaac aagtatatta cgacaactac tgcaaaggtt cttcctgtga 61260
gcactgtatt atatagagtc gatgatgcta ataaaaggct ttatttacaa ggttctattt 61320
tgctaaattc taatacagtt gagggtgtaa atgtcgactt tagtagtgtt gttaaaacaa 61380
ttttatctag tcaagcacta tctttagggt atgcgagtgg gtggcagaac tggacagatt 61440
tgaaagttca gcttattacc cctgcggcaa taaggattcc tgcttctttt agtggattag 61500
cggttatagg tgtgaatact actccttcat attcagctac tgatatagct tatgtaactt 61560
atgacgaact agtataaaaa aataaatatt cgaaaggaac gattaaatga tagctactag 61620
gaatattatt ttaataagtt ttgatagcac ctagtaatac tctgttaatt attggttgta 61680
attatataga aagtattaaa gagggtggat attaatgaca catcgaatta aatactcctt 61740
attttggaca ggtatcgaga ctatgtcaat tggtatcctg tttcttactc ggcaggattt 61800
actattagaa cataatcagt atgctcccta tctgcaatta gcccagtcag taccaataag 61860
cttactatat attattgttg gttttgttgg ttcactaata gttagtgcag atataaataa 61920
ttataaatgg gttatgttta ttataacaat gtatcaagtg tgctggaata tattatcgtt 61980
agcttttgtt tggcacacct ttatggggtt tggctcacca atagatgtca tttttacatt 62040
ttcaattatt atgagaaatt atacagatgc ttgggcatat agtgctcagt cacaaagaga 62100
aaaggaggac aaagaaaatc taacactttt tctaaacgat aatcaacgtc aacaggaaaa 62160
aataagagag aaagaaaaag agttagaaaa aggaagtagg gatgggaagt gaaagattgg 62220
ataagttata gtgttgcact aatatcagcc ctatctacga ttatattggg tttatattcc 62280
agagtaagca ctagaagaaa aaatacagat agttcagact ttaagcgaga gaacctgtat 62340
gctggggagc ttaaaggaac tttagcacaa attaaccagt taacagcaga taagctagac 62400
ttagttaatc aaataattga acttagacag actataggaa atatgaagtt ggacctcgaa 62460
gataaggata atcaaataaa tatacttaag gggagactag ctgaactagg acatccagtt 62520
gatactttag gaagtataag tgattataaa aataaaaatt aaacatgata taattaataa 62580
tagatatata aattagaaag gaagttttat ttatgaatat tgacgcatgg acagaaggat 62640
tgaaattaat taataaccca agtgggatga ttgctattat tgttgtaacg ttagcactta 62700
cgcaagttat taaacaatta cgaatttcta atagatggat gcctttagtc gcggttggtg 62760
ttggtttagt ttgtggttta attattggtg gattaacaac gacaggtgca ttgtttggcg 62820
ctgttgatgg tattttggct ggttgtgccg cttcgggggt atttaatgta ttaactctat 62880
ttacgagagg agaataacat atgggagcaa agattatttg tgatgtagct gtttggcaac 62940
cttctaattt aacttatttt aaaaaattga agtctaaggg cgtatatggt attattatta 63000
agctaacaga gggaagcaac ccgggaagtg catatggtaa tccaagtgct aaggcacaat 63060
ttaataatgc tcgtgcggca ggactaaaag ttgttggttt ttatcattat gctcgattct 63120
ggggagatag tgatgccgca aatgaagctg attggttcat taagtataag gaaaaggttt 63180
taggaattac tggtaaggat tatgtaatgg tgtgtgatgc cgaagataat agcctaaata 63240
atagtcgggc aggattaact tctaatatta attcatttat taaccgacta aagtctaagg 63300
gttataagcg agtagatacc tactcaggac gttcctttat ccaaactaga acctaccctt 63360
ctaagctagt tactaagaat ttatggattg cttcttatgg tagtgcttct gctggaatga 63420
aatgtggcac ttggcaatat actgataact ttaagggtct aggtgtagat gcttcgttag 63480
actacagtgg attttattct aaggtaaccc cagaagttac aacaaataag aaaccaactt 63540
acttttcatg gaagccttac atggtaactg ctaagactaa aattggcatt tacattgata 63600
aggacctaac gaagttgaaa cgtaagtacc ctgctggaac tgactttaaa gtaagcgagt 63660
taactaagtc atcaaagaga acacctagat ttaagacaac tagtggtttc tatatctctg 63720
ctaataaaga ttatgttaat aatagctatt acgtagatga tacaattaag gaaattgtta 63780
ctttgaagac tatttggatt tacaaagaag caactcgtaa acatcgagta gctaaattca 63840
gtaaaggaac tgactttgtt attaaggata ttcaagacat cggacatggc ttaacatcct 63900
ttaagactca aagtggttat tggattacaa ccaataagaa atttgttaaa aaagttcatt 63960
gatactatca ccctcaatcc tcctataaat tagggggatt ttttgtatgt tttaaattta 64020
ttaattttgt gatatacttg atgttagaga ttatacataa agaaacgggg gcatttaaat 64080
gattagtgca tcatgtgatt taagcctatc cattaatgat ggacttaaaa aattcttatt 64140
agattgcttg gattatactg agaacattaa aggcagtttt attgcaaagt ttagtggtaa 64200
agatatggaa attgctagtg gttatgaccg gagaacaatt agaagaaata tttataattt 64260
aaaaaatagt caactagtta aatctattca aacgcgtagg ggtcgctctg gtggctatat 64320
tattgagttt aatgatgatt taattcattt taatgtagtt agtaacgttc atacagagaa 64380
ggccccagat gagcctttaa agacgtttaa gcctactcga aaagagaaga aagaatttaa 64440
aggcgaacga gatagaaaat atgattccct gcttaaaact agtaagaata aatatgatgt 64500
attgatggat tatgatggta ctggaaatac ctattatggt tacctattaa gcaaagtata 64560
tgatgcttat gtacaattgt tttctttaga aacatcttta cgttctgaat ataattttga 64620
tattaaatat tcagagaatt acacacaatt tggtaatggt aaaattattg gctctgctaa 64680
cctaacaact tttactaaac tatacgtatt ctgcaaagaa aataatatta atcctgttta 64740
ctatatctca gctatttttg aacaagaacg ttttctaact aatcatttta caagagaatt 64800
taaagttcct tatgttaata ccttgttagg gagaaaagat aacttcttat cacaaagaga 64860
gtatgataag aaatatttct ttacagatat taagagtcca cacgagacta ttaggtttgt 64920
tgataaccct gttgtgggta gtattaataa cttattcatg tttcttatct ataagaagtg 64980
ggatattaag gctgtttcgg aatcctatca agaagattta gatagctata cagaagaagt 65040
tattagatta ggctacatgt ctaaagataa ttgtgagttt gaaggaaact atgatgaaat 65100
ctatgaaaag gtaactcgtt cgggtactgg actattagaa gaaattaata aaaagagttc 65160
agatgatgga ttcaatagaa cggttggacg tttgtacgca acttcaatta agggtattcg 65220
attcccttat cgctctggaa ttctatatga tgctaatgtc tctaaatctt atgctagttt 65280
atttaatggt gttaagcaga gtgatattaa gaaatcttta gctaataagg atgacttagt 65340
agttgatgac ttgtattcaa gtgtagttgg atttagtgcc cgtgaaagtc atgtagccac 65400
gggagatatt attaattttg atgatattag agaagagctt atgttgcggt ggcctgcttt 65460
attaaactgg gactctgctg ttgaggttgg aagtttaatt ggagaccaac ttggattatc 65520
taattattta atgacaactg atgaatttaa tgataaacta gaaaaagagg gtcaatcatt 65580
attaccttta gatggttatg gtaaatttaa tttacctttg ctagttaaag gatttagtaa 65640
aaaatcagca gacttgcgta gtagtgaaaa tagacctgca ttaaagcgat atagccaaga 65700
ggtggaaatt taaaaatgga atcagaagct ttaattcaaa agcaattact atacagagca 65760
ttgagttctc cctacttctc tgttgagatt attggtagaa ataactcagt tctttttcaa 65820
ggaaatgaaa attatcagat ttatggaaga attttagtta attattataa cgttagtaaa 65880
gaacctatta ctgaggaaac ttttaaacta aaactaacta aaagtttgaa ccagttaaat 65940
tctgatggtg atttaggctc cgatgattat actgaatatt ataatgaagt taacgacatc 66000
ttcaattcaa aagtagatac ctcagataca atgacagaag aggttgggaa ctatgttcgt 66060
aagaagttag gtgaagccgc tattttagag agtgctcggc gttcatcaga tgaagaagat 66120
tttgatttag ttaaagaagt tggcgaacga attgaagaca ttaattcttt agatatttct 66180
ggacaaggaa ataaagttat ttctgtttat gaagattatg aggaaaagaa tgaaatttat 66240
aaagagttag ctagaaataa aatttctatg ggaatccctt ctatggacct tgcaactggt 66300
ggtggcttag ctaagggtga agttggatta attgcggccc gttctggttt tggtaaaaca 66360
actacattaa cttcttttgc taatagttat acgtttaatc atcataatgt aatgtacttt 66420
tcattggaag aaatgaattc tcgtatgttg ttacgttttg accggttagc tttaaataag 66480
cctgctaatt ttattttgga taaagatagt aatttaacag atgagtataa gaagaaatcc 66540
aaggagttct attctactgc actggataag ggaattatta gtaatcttta tttataccga 66600
acgtcacctc ataccattac tattgaccaa attagacaaa ttattttacg agtagaacgt 66660
cagaacaata ttaaattaga tgttgtcttt attgattatc cagacttact gctagacaat 66720
aattcaacag gtaatgaatc ccaagatgga ggtcgtattt tccaagatat tcgtaaaatg 66780
gcccaagata catctaccct aatatggaca gcaactcaat tgaatcgagg ttctggtgac 66840
caagaaacaa tgactttaga taatgttgaa ggttcttatc gtaagaagaa tacggttgaa 66900
tttgctggga cagtaaatcg tacaaaagat gaaaaagaaa atgggttctt acgtatttat 66960
atcgataagt tacggaaccc tgatgccttt gatggagata tgctatactt taagtatgat 67020
aaggattcaa tgagaacgtt agaagagaaa gataatgatt atgttcagca tctatcttta 67080
ttaaagcaaa ctgaaagttc tacaaaagag tctcgtaaag acaagtttga ggatgaagct 67140
gggaagcgta gtaagaaggc tcaaatgatt aatacgacat tttcagattt accctagaaa 67200
ggtatatgat tattaatggc taagttatat gtaatttcag attttcatgc agatttatat 67260
acacagtatg cccatcctgt agatgataat aggtatcaaa atacaagatt caagcaccaa 67320
atggaggttc ttaatgatat tttaagaaag tcctatacta atgatgctag tattgtattt 67380
aatggagacc tgtttaactc tagggtagac attaatcaga ttgtttatac cggagttgtt 67440
tcgactatta caaattggct acctaaattt aaagataaag gtttaaccat gtatttttta 67500
gctggtaatc atgaccaatt tgataatacc cgaaccccag cttcatcaat tgatgtattt 67560
aatgagattg cagggtttaa agatactgcg gtttctattg atacaccaga acagtttaac 67620
cttgatgaat ataatttatg ttttgttcct tatagtgaag atattgattt tcttaaagat 67680
aaaattaata attcatttta tattgataaa gataagaaaa attggttatt tgttcactct 67740
ggtgtagagg gtgcagttca ggggaagtgg aatcatcgtt taggcggggc gtttaaccta 67800
tcagatttgc gatacaagga gtttgatgag gttgtcttag gacattacca caaacgtcag 67860
aaactggctg acaacgtgtt ttacgtagga aatacgatac ctttaaatca taacgatgat 67920
ggtcaggaaa aaggctatta tattttagat acagaaaatc ccccaaggtt tgttaaagta 67980
gaatccccgc tatttgaaac tatcgattta tcagatacgg atttaagtag tgaggaaatt 68040
aatgaattaa tcaagaataa ttatgtacga gtaattacta gtaacaaaga agacttggat 68100
aaattacaag aagagtctag taagaatggg gataatgtaa gtattgctta taagcctgag 68160
ttaaaagata gaactagatt agatattaag gatgactctg gtgtatttga tattgttaaa 68220
gcttatagta agagtaaagg atattcagac ggtgtaacta aaatagcgct aaatgtaatc 68280
caagacgtag ttgaagaggg taatgaataa attggaaaga aagattacag ttccactata 68340
taaagagtta ttagattcaa gtgcagaggg tgtatttgta tacactaagg ataattgtcc 68400
taaatgtaag atgacaaaac ggattatgaa tactaagggt attgaattta ccgaattatg 68460
ggtagacatc aataaagatg acgatatttt ggctagttta agaatggcag ggtataattc 68520
ttttcctgta gtagttgtta aatctaaaga agataaagtt aaatcttggt gtgatttcag 68580
gccaaacaac attaacagca ttaattctaa agatgagtag ttaataacta ctcttttttt 68640
tgtggttgca ataactaatt acatgtgcta taatgattat aataggaagc ggggtataat 68700
acattgaagc ttttatcagt aggttttaaa aattttttat cctttggcga tacttataca 68760
gaagttaact taactaacag aggacttgtt ttactagagg gaattaatga agactccgaa 68820
tcatttgcca gtaatggctc tggaaagtca agcttaatct ctgctattgt ctatgggctg 68880
tatgggaaac tacctgatgg aacttctggg gatgaggttg ttaatgataa aacccagaag 68940
aatacgcagg taattttaaa gtttgaacag ggaaataata agcttgttat caagcgttac 69000
cgcaaagata aaaaatataa gaataaagtt attctattta ttaatgatgc agatgctaca 69060
aagtcatcag taaaagaaac gaatgaatat atccaagaaa ttattaaagt agatatgaac 69120
acttatttac aatctgttgt ttttggatta ggaaatatca aaacctttac acaggcaaca 69180
gataaagaga aaaaagaagt tcttgaagat attgctaaca tctcaattta taagaaagct 69240
caattagttg ctaaagataa aagcaaagaa attgagtccc aaaaaacaga tgttgagaat 69300
aaattagtaa ctgctaataa ttacattgaa gcttatcaga agtctgttga taattatcaa 69360
gaagggacta ataagctatt agataattta aaagtaatta agagtcgtgt agacaattat 69420
gaaaatcctg ataagttatt aaatgaaatt aaggatagta aggacgcttt aagtaaaaag 69480
gtaaaattat tagaccaagc attagatgac ctaaacaagt caaattactt agaatctgat 69540
gaatataaag ataataaata tatttataat agtatgtcta gtaaaattgg ttctgtaact 69600
tctgaaatta atagaattga taaggatgca gaagaattaa agagtcgttt gattcagatt 69660
actaaccaac cgggtaacga attatattgt acttattgtg gtagtaagtt agacgatgtt 69720
catcgtagta aagagctaaa agtcattaag gataatcttg tcactttaat tagtagcaaa 69780
acaacttata gtaaagagtt gcaagagtta gaagctaaaa aattagatag tgagaaagtt 69840
attgaggatt tagagaacaa gaataaaaat ttttctgagt ctaatagaaa attatcatct 69900
gctagaaata aattaaccga agatatttct agtttaaata ataaagaaaa tgatttaatt 69960
agtaccaaaa atcagtatga tagagatata gaggagttgg ggcatctaaa agaagaacta 70020
gctattaatt ccgtagatga attaaaaaaa caaattaagg atgaaaaaga aaaggtcaag 70080
aaacttaatt tgttaaacgc agagttagaa gataaaagtt ctaattataa aaaagtaatt 70140
gatatgtact cagacaaagg tgttaagtca catgttcttg atttagtact cccttatata 70200
aatcaacggg caaattatta tctgagtatt cttacagata atacaatcaa cattatgcta 70260
tcaaccacta cgactagtca aaaaggtaat gtatctgaaa agctttccgt agaagttaat 70320
aacattaatg gtagcacaga atacaagaga aattctacag gagaaagaaa acgaattgat 70380
ttatcaattt ccttagctct acaggattac gttatgtccc gtagtggaac caaaactaat 70440
tttattgcgt atgatgaagt ttttgatgga ctagatagtg ttggtattga tagactaatg 70500
aatcttttga aagaacgagt aaaggaagtc cctagtattt ttgttgtcag ccataacaaa 70560
gacttaaaag aactatttga aacctcaata actattaaga agaaacgagg aatttcaaat 70620
attgaataaa aaggtatcgg gtagcttgcc ggaaaacaag tgtggagaaa atgaattaaa 70680
gacttttgca tataaaacaa gtaagggtaa tacttatgtt agggcttctt gctttaacta 70740
taagggaaat ggtgaggaat acaatttacc agtagaaaca ttaattgcat ggtatccttt 70800
gtatttctat tatgattggg cttatgatta tttgtatgaa aaagttcatt taaactacta 70860
taagggaatt aatcaggtag atagagaatt tattgataat aatgatatta ttacttttga 70920
agattgctta acttttgatg gtaattataa ttttaagact gaaaagaata tcattctaag 70980
agacaatatc attttaatta aagaactaaa taagcaaggt tttgttacct tcgataagtc 71040
tggttattct gtcgaagatg ttgctcgtaa tcaaattaag gtagccaata ttttagatgc 71100
cgtttggact acttgtgaaa agcgtaagta tgagagcaaa aatagtacag aagcttatga 71160
ctctagttat aacgaggaac aaaatagtcg tgaaattcta tcatatatga caaaggatga 71220
agagtaccta tttcaactta tgggtgcggc tactaagatg aatactatta tgagtaaagt 71280
tgttcatgcc aaagtttacg tatcaagtag taaataattc gaaggtgctt aagtaatggt 71340
taagtataat gcaaagaata ttatgtatag actgacagga aataatccag tagaaatttt 71400
atttatcggg gacaaaactg aatacagata tacttgccct atatgtggtt ctgaacataa 71460
taagttttat atggatgcta acacaggtgt atggagttgt tttaaccacg gcggaagtgg 71520
taatctaatt aacttagtta aggaagtatt ggattgtacg acactaaaag ctaaagagtt 71580
cctaatagac agtgaaatga ctgtagagga acaagttcct gaattagcag aagctgataa 71640
tatgtttgat aaagtagcta tcttattagc aaaaaattca gagccagtaa agtcaaatac 71700
aattaataag attatgccta agttgccaac taacactaaa cgactattag ataatttaaa 71760
ctcatacgat gctgttccat tttttagata tttaaaaaaa cgagatgttt ccttacaaga 71820
tattaaagat gcagatatta gatatgtgat taatggagat tttaagactg cttctgataa 71880
agatatgacc atttataact caattatttt tataacacac attaacaaac aaccagttta 71940
ttggaattca aggtcaatag aagccaaccc ttatctaaag tcttttaatg catcaggaaa 72000
agatacagaa tatactcgta gggatgtcgt atttggatta gataaagtat ataataaaga 72060
tattgttgtt tgtgagggtg tatttaacgc tttaatggtt aatgactcta aacatagagg 72120
tgttgcaacc tttggtaagc aggtaacaga tattcaagtt aaagatatta tagaaaaact 72180
tgggtctgaa aataaactta ttttatattt agataatgac gccaagcaag aggaactaaa 72240
attagcagat aaatgtattg agtttggttg tgagccaagt cagctattta tcgttaatag 72300
tccttatgga gatagtgatg ctaatgatat tggtaggaaa aaggcgttaa atttagttaa 72360
taaagctgta aattacaact tagactttag attaaaatat atatttaatt aaataaaaaa 72420
tactatagga aagatggtta ttatatatga tttatgtcaa tgcaccgatt ggggtcggaa 72480
agacccagtt aactgagatt ttatcagagg atttaggaac aaaggcattt tatgaaaagg 72540
tagacgactt aaaaatgcta cacaagttct atgccgtggg ttcagatagt cggtatgctc 72600
tcgcctttcc tttacaagtt gcttttttaa attatcggta tcagcaatta cgtgaaggat 72660
tacatttagc tgaaacggag ggtatgaaaa ataccattta tgattccagt ttattatcag 72720
atggtttaat ggcttataat ttgtttaaac gtggagagtt tccagaagaa gagtttagat 72780
tatatcaaga gctatcacaa aacatgcagg ctaatgtgtc aggacatcct tttagcggat 72840
ttcctgatgt agttatttac ttggactgca atttcgaact catgttagaa catattgagg 72900
gtcgcggacg ggatatggaa gttattgata atgataagaa aaattattac catagtgttt 72960
gggaaactta taatgattgg tataattctt atgcagggtc tccggtaatt actattgata 73020
tgaataaata tgattatgtt aataatttag atgaccgtaa gaatgttcta aactatattg 73080
aatcagaatt aggcaattta gggttgttat ctgctaaaga attggaaaag ttaaccttga 73140
agcatgatac agaatatagt aaggtggcac aagttaatgg atagagaaac ctcagaacat 73200
caatccttgt tatcctttat tgattatttt aggctaaagc aagttttaga tagtaagggc 73260
actttaccga caatggatat taccttacat gacaaagata aattgacata ttcagaagct 73320
tatgatacgc ttaatttaat tagtaaggat ttaagaaaat atacagacag atatagttca 73380
ttgtctattg atacaattgg aattttatgt actttgttgt cagataaagg tattctaaac 73440
aataaagata ttgaagcaat taaaaaaatt attgtcagtg gttggcaaga aaattaaaga 73500
aagtaaggta attagattat ggcaaaagat tttaatagtg caaagaataa ggaagatatg 73560
caattagcat ttttgtatca tgtaggttca cctttaatga atgaagacca gattactaag 73620
gctaagcaag ttttaaatcg tgaagctaag gttggtgact tactaactgc attagatatt 73680
ccgctgaata gtctacaaaa gcaatattct ttgattgcta agcaattgga tgtcactcaa 73740
tggattattt cgcataagtt ccatgttacc gaagaagagt ggtctaaggc cgaagaagaa 73800
gttgttaagg aaaatgaaat tcaaaagcaa gaagttgcta aggagtttac taagaagcta 73860
aagcaaatta ctaaggaaaa tcaggcgggt attagtgatg atgttaaaaa gaatcctaat 73920
aaggttgtta aggctgattt tggaactaaa aagtaggggg actcattgtg agtgaatcta 73980
gtatttatgt aggttatgaa gacaagttac ctaagactat tgagtatcta aatgcaatta 74040
agggtatttc agttaagaaa ttagcagaaa attatttgct agagtctgat ggggtagtag 74100
atgataaagg caaccccctt gattctatta caggtgtaaa tccagatgag ttagctttag 74160
atgaagttgt tactcaattt aaaaatgcat acaatctatc agaagaccaa aggtatattc 74220
aagcaactct agcaccggga aattccttaa agagtcaagt attagttaat aagctgtata 74280
ctgctacagg tgaagattta gggattacct ttgataataa gctggttagg gataactttg 74340
atttagacaa ttattggtat gaagctctta gcaatggttt ctataatgtt actaaagttt 74400
ctggaaaaca tggggttatt gttttaatta ttttgcctaa tctctcggct attttaacag 74460
attccgaagt agatgatgct attcaatgta tccattcaga agaagggtac aaaaaagcca 74520
aggaagtctt cacaccgatg tttattaata agctaaaaca tgatgcagaa gtctatcagg 74580
attttgataa acgtatgcga attgttgtgc ttgataaaga tgcagatgtt aatagctatt 74640
tagttaataa aatttatttt tctcgtaaag ttagctatgt aactaatgtt ctttcatcta 74700
atggaatgct tagctctggt agtctcggta ttgggggcta ctagtatgaa tggaaaaggt 74760
agaaatgcta agggaagcaa ttatgaaaga gagttagcca agaagctgtc taattggaca 74820
ggggaaaatt ttatgcgaac tcttcaatct ggtgctggtg ggactagagc ggttgatgaa 74880
attagaatga ctggcgactt gtttgcacct ttaggaagta acagttcttt ttcttatgaa 74940
gctaagaatc atgcttctac tagattaaat catgtattta ataataatgg agatattcca 75000
gaattttgga aacaggcaac tactgactgt cggagagtta gaaaatatgg tttatcccca 75060
atgttattat ttcatgtaac tagagaagca gactacgtac tgttacccta tacagattgg 75120
ttatttgcaa atttagcagt tatgaagcac ttaccttgtc aatctcaggt tacttattat 75180
acggaagaac gaacaaactc tttatatgtt tatagaacga ttttaacaac gttagacgcc 75240
ctatgtacat tagatgcaca agaggtgttt aaacactata aagggttaga ctgggataag 75300
ggtaatccaa ttgagactca tacagacgaa gaattagaaa acgcccagca ggaattaaat 75360
ttatggttaa gcgaagaaaa atcgtcactt tagctacgag atgaatttac tttattaaaa 75420
acaagggaag aaaactcgtt actttagtga cgagtagttc acggttaagt aaggatggag 75480
gatagaaatg aagaagtggt tagatgaaga tggtgtagcc aactttaagt accaaaactc 75540
actggtaaaa gtaacttcta ctgattttta tggggagtat ttagcacatt ttaattttaa 75600
tagtcccgta ggtaattcag agtttgttat cagtttagaa tataaggatg gattcgtgac 75660
tatccctagt ttaaatgact ccgcctataa cattgatgta cctgtaaaag agcttactaa 75720
gttcttacaa gttattaatg actatatcac ttgcctagag gatgactcta aggaattaga 75780
cctatcaaaa ctatagtatt taattaagca gaatgttata attctgcttt ttttgtgttg 75840
aaaacttatt ctatttggtg tatgataagt agtaacaaga aaggtaggaa cttatctatg 75900
acaaagattt atttggcaac accatggttt aataaggaac agaaggaacg tgtagaacgc 75960
gctaaaagcc tattagctag taatcaaacc gtagatattg tacatttccc ttttgattat 76020
cagtacaaga attcgacaat tgagaataag gatggaatct ttggtagctt agaatggcaa 76080
gtagcaacgt atcagaacga tttatcagct atgggaactg ctgattgtgg tgtattttta 76140
tatgatttag ataatgttga tgatggaact gcatttgaga ttggctatat gcgttctatg 76200
ggtaagcctg ccatcgtagt tactttctca cataaagaag atgtaaaggt taacttaatg 76260
attgctagag gggctaccac ttttatcgat ggtgatactg atttagaaca actatcctcc 76320
tatgacttta atcacttccc atcaaaccca gtaagcacac acgaggtctt ttaagaaagg 76380
agtctaatgt attatgaatt atgcttttgt actaattaaa gcaggaaatg atgttccatt 76440
aggcgtattt aaaaggcatt ctgatgctat tactagtaag ggagagttag aagacaaata 76500
taaaggtaat tttgaagtta tttgttatgc agttcagtca gatattgtaa gtgaccctta 76560
tacattcatg aaagcaatcg aggattacta atgggaaaag tattatttta aattagaata 76620
tactataagt taaaggcggt agttataatg agtaaattat tagaaaaaaa caaattagaa 76680
gtagaacgat tagagccaga tggttataca caggaagcgg caaaagatgc tttagaagct 76740
atgaaagtta ttactaagca aggtcacagc ggaacttcat taggtatcct aaaatactac 76800
ttagaccgga tgattgaggg gaagccttta acacccctta caggggaaga ttctgaatgg 76860
gaagaacttg acgaaggcat atatccagat aatcctgaaa ttacagcctg ctatcaaaat 76920
aaacgatatt ctagtgtatt taaggaagtt tacaagagtg gctctgtagc ttgctatgat 76980
attgatgcct atgggtatag tgaagatggt gaggggtctt atgtgggtaa tagtccaaaa 77040
tattatgtag aatttcctta tatgcccggt gaacatatgg ttgttgattt tcctacaggg 77100
tttgattatt gggaaaagta tgattatatt cttcatagtc actctaatga atatgaaagt 77160
attgctagaa atgtattttt aaataaccca gaagattgga atatctattg ttcaaaccac 77220
tatggtaaga ctaatgggga ttagcatata tatatcattt aaattaaagg taggtaaata 77280
attaatggat gattgggtag caggtttttt aaccggacta ttagtagtta ttttattacc 77340
aactttgttt ggtactatta ctatcggagt catgaacaac ggaactggcc ttgcaaagtt 77400
cttcatgact tgtataattt tgattttgat tatactaatc tggattataa ataaagaata 77460
gggaaataaa taatttgctg gttactggtt gtatgctttt tagaaaagat actgcttaaa 77520
taaatataga gaagtgggaa ctaataatgg gaaaagtatt ttattactat ggaacaatga 77580
agtcatctaa aacagctaat ttgctcatgg tatatcataa ttacgtagaa aaaggaatta 77640
agcctatcct agtaaaaccc tcaacagata ctaggagtgg taacttgcaa gtgtccagtc 77700
gggtaggact atcagaggta gcagatttta aagttcctta tgatggcaat tcccataatt 77760
gggtgtatga gattatggag tctgctatta aggataatcg tcctattctg ctagatgaat 77820
gtcaattttt cagcaaagat tttgttaaag aattatgttc atgggcacat gattttaaca 77880
agcctgttgt agtaatggcc tatggattat tactaaactt tggtggggaa ttgtttgaag 77940
gctcaaaggc ttggattgaa aattgtgata gtttgcgaga ggttaagact atttgtaagt 78000
attgtggtcg taaggctact cataatgttc tatttattaa caataagcct acctttgata 78060
cttcaagtgg agataccttt attggagata ccgagtatga agttgtttgt tctgaacatt 78120
gggaagaatt acattcagac acccgaaagc aatcaattat taattttaaa gaagactttg 78180
ttaaacgata ctacggtcta taagcatatt aagtgtttat caaaatgaaa gcatttttga 78240
agataatgtg catatattta ccaatcgctt tagcttatat tattctatac acgttaacat 78300
atccagtaat aatcttatct gaatatatta gctataagtt agattcatgg aaaggtggta 78360
aaaaagatga cagatagaca aaaaaattat ttacagaaat tgctgagaga agattactct 78420
gtgttaagtg tttcaagtaa agatgctgtt gctgaatacc ttaaattaaa aggtaagtca 78480
atggatgaac tagacaatac agatgcctct attttaattg aattgttagc ttcggcaaat 78540
aagtatacta aaattttagg tatcttaaaa gaaaaaaatt cttataatta aatgtttgta 78600
tttaagctca tgtatatggg cttttttatt tttgaataca caaaagtgta taataaaagt 78660
aaaaaggttg gaatatgtat gagagaaata acctcagtga atatagacaa tacatataga 78720
agtgcaaact taaatgtatt gattaaggat agtaacaagt ataaagttgt taatgttaat 78780
agaatgaaag agtctaaaaa aattaattca aactatattt atcgtgtaac ttataatcgt 78840
agaattaatg ataatttagt ttatgattta attgaacata attgtcgatt agattatcat 78900
acaaaaacag ttgtaccctt tcctacatta ttaaatatgc ataacaacaa gaactcagaa 78960
gctatttacg attatcatgg taaatgggaa cagcgtgaga tagagaatat gaatcaagct 79020
tcaatgcttt gtcgaacggc tgtggaagtt aaaattaagg ccggaattac caacccgtat 79080
gctttacttt ataatttatg ggatactcgc tatttagtcg atagagttat ctttaacttt 79140
gaattaatga gcaaaaaaga atatacaatg ctcccggaaa ctgttaaaaa gtattatgaa 79200
ttcaatgaag atttgcagaa gtatcaagca acaccggagg gaaaagtatc ctactataca 79260
aaggttcatg aaattttagc tagatggcaa ttacagttat ggattatgtg tgaagatgaa 79320
gttgatgcta acgaaaccta tacacaaggt atcgcattat cagacgtgat taatacttac 79380
tacagtgtcc ctaaacgtgc acaacaaatg ggggtgtagt gaatgttaat taataaccat 79440
gaattagcta aactaattaa aaaggattat gcaaaaaata caacgattaa agatattcta 79500
tatattttgg aatcagaaca agaagttatt ttaggggctt tacgtgaagg acatactgta 79560
aagattggaa aattatataa gatatatcct aagcacctag aaagtcgtac tcactacgat 79620
ggcattcatc ataaacgcat taatttacca gatagaaccg taattaaaga aatgcaatta 79680
tctgacatta aaaagttgta taattaatag tctatagaag taaggggtgt cctttacttc 79740
ttttagtttg tatgataaaa tttaatcata aatatttaaa aggggttaaa gcatgaaatt 79800
aatggttgtg ttagatttca ttagacttaa ttatgttaat gatgatggag aattcgtttt 79860
cttgaatact cgtgcaggta agcgattaac taagattata acatctaaga agtttgggtt 79920
agctcttgat agttcggatg ttgacatttc tttcgcttat cctagagttc cacccttaac 79980
ggttaaagga aaaccgaaaa atattacaca gacaatggga aaaccttatt ttgaaaaact 80040
acaggagcat attgtagagt ataagccaga tatgattatt agttttggaa atacggctgt 80100
tcaagggttg ttaggtaaaa aaggtattga taaactcaga gggattcctg ttcataagaa 80160
ttttagcaat aaaaataatg aggagtttga gacttgggtt gttcctatgt atggtttaga 80220
atcagtagat gtagaaccta gccgctgggg aacaatgtca aaggatgttg acttagttaa 80280
gaaaattatt catgaaggta ttgaatccat atcttccggg gtaggtaaat atgaattagt 80340
aacagatatt aacagagtaa aagatatttt ttctaacatt ttggttaaaa agaaatactc 80400
tattgtagct gtcgattttg aaacaaacac cctccacggt caataccata atgtgcctaa 80460
tagaaataat ccagaagagt tagtttcagc taaacctatc attttatcta tctcttggga 80520
agagggtcag ggggtttcta tcccagtaga ccatcaattg gcttcttgga ctcctgagca 80580
attggctata attcatgaat tgattaagca attatttatg tcagaacagt ggaaagtatt 80640
gcacaacggt atttttgata ttactttttt gaaggaaaca attgggctta agtattctaa 80700
gaattgtgta gatactctat taatgtatta tattggtgtt actgaggaga ctgacgtaac 80760
taaaacgtta aagggtcttg catatcaata tactaatatg ggtggttatg agtccccact 80820
agatgactat aaacgtaatt ttttgtcaga gcggcataat gcttggattg ctaagatgga 80880
aaaacgcaag gaagaaactg gggagaaata ccgtaaaact gattatgtgc cattagttaa 80940
tgagattgat ggtggggatt tcaattatga atggattcct ttagaaatta tttaccctta 81000
tgctgcggcg gatacggatg cctgcttaag aatttataat aagttaaaga aaatcattaa 81060
agataacgct aagtggacta atcttattta taactattat ccaaagctac aggatgctct 81120
ctcagaagct atgaagaatg gtgtcaaaat tgataaggat tatgcaaaca gaattaaacc 81180
aatttatgag gatgaactta ataaaatatt agaggagatt cgtaaaatac cagaggtcaa 81240
agaatttgaa agcagacgtt taaagattat tagtgatggt gttgttgcta agaagacacc 81300
taaaaaggat agaacagatg gacaagataa agcaatcaaa gaagctaata agttaagagg 81360
tgtcggcagt gatggaagac ctaagtatat gtttaatccg ggttcttcta atgataagaa 81420
atatgtttta tattttatta tgggtatgac tttgccagat agttctgagt tttatacaga 81480
tactgctaaa aacaacggaa aaattggaga taaagcaact tgggagtctt ataaaacgga 81540
taaaaaagcg gctatacctt atttaaaagc caactatgat agtaaattgc ctgaactttt 81600
agagagatat tctagtctag ctaccgtctt aaaagatttc attgtaaagc ttcctaagat 81660
attagatacg catagtttag cacatactag atttattatg acagggactg taacaagtag 81720
gttagcttct agcggggatt ataacgtgca acaacttcct aggagaacag cagaccccgg 81780
aaactttaaa taccattatc ccgttaaagg tatggtaaca agtagattta atcatggggt 81840
tattttaaac attgactttg caactttgga aatatatgtt gccgctatgg tatctcaaga 81900
taaagggatg gaacagattc ttttagatgg aaaagattat cacagtgcga ctgcacgtaa 81960
tatttttaat attcctgatg ataaagaagt tttaaaagat gtacgtagtc aagcaaaggc 82020
ggcctcattc ggtaaaaatt aaatgctgac tatctaagta attagatatg caaaaactct 82080
gttaaacggg caaagtaaaa taataactac aataatgaat aacgaatata ctggtaagaa 82140
aggctaagtc caagtagtta tggatagagc tgaccgccgt actaaatgtg tgattagact 82200
tgtatgctct ctatttgtta taattaagta agatgtatca aatggagggg tataataatg 82260
aaaataagta tagaacagcg aaaaacaatt ccatattatc ataatcttta taatcgttta 82320
gcctgcataa ttagtcatat tcgggatagg tgtactaatg taaactgctc tgaatatcat 82380
aattatggtg gccgtggggt tatatttgac cctaagtggt caactacaga agggttctta 82440
gatgatgttg accatataga tggctggaat gaggaaaaat ttattaacca tgaaatacaa 82500
cttgacaagg atataaagta taagggaaat aaactctact caaaggatac ttgcaaatgg 82560
gtatcgcatg gagaaaatat gcatactctg ccatccgttc agagaagttt tggtgcctat 82620
aatttatata ctagggaatt agtaaagttg agttgtgtta aagatttttc tgaaatgtat 82680
aatctaaatt tatccgtatg ctatgctgtc cttaaaggtc gtaagcataa aagcggagat 82740
tggattatgt ggtacctaga tgataaatgc ccggaggtaa cttatttttg tgcaagtaat 82800
gggaaagtaa cgtacaaaga tataaataaa tccagacttt ctaagaagct taatgtaatt 82860
aagtctacgg ttgttagagg gtttaaaaag aaaaatccgg gttataagga atggaaattt 82920
ttcgttgaga ctatagattt aaacacacta aaggtctaac gactaagctt ctaggtagct 82980
attcaaatgg gaatagtgag aactagataa gaaaacctta ttaatttaag gaagtaaagc 83040
agagaatcct acaccaaaca gtaggattaa gatatagtct aaaccctttt aaatactagg 83100
aaactagggg tactaattgg ttatttatgg ggaaggtccc gcaggattag caagtagtga 83160
aaaaatacct ttagatgaag ctactagagt tattgacgga ctaatgagtt cttatcctag 83220
actagagagt acaattaagt attatcagga tatggcaaga tataaggggt atgtagagac 83280
aatatcaggc tataggagac gtttaggcac cgttaagtct aaagacaaag gtaaggcatc 83340
cagagcgctt agacagtctt ttaacgcagt tattcagggt tctggtgctt attgtactaa 83400
cagtgccctg attaagttac atgagtattt tttaaagctt aatctaaagt ctttaattgt 83460
ggctacagta catgattcgg ttgttattga tactcatcct gatgaggtta ataaagtagc 83520
aacaatttgt cagtatgtct ttagtcattt agatattcca gaagttgtta ataatgatat 83580
tggtgattta agagttccag atgaattaaa attacctaac aataaattcc gttttccttt 83640
acatggggaa gttgaaattg gagaaaatta taataacgat gttgagtatg acccggatga 83700
acttgctaag tttaaacatc ctgatatgta ttgtcgatat aactatgcta aagttcaaat 83760
aaatgaatat ttaagcaatg gcaagttgac acaaaaagaa tttgatgcta aacttaagaa 83820
gttagaaagc acaaaggaaa ttttcatgca ggcgtgagga gtgaatagat aatgtccgtg 83880
gatattagta atatcaagac tattggaacc attaagtatc aagattatgc aggaaatatt 83940
aaggaaattg atgtggagaa gtctttggct ttttcctccg aggatattcc gtatgagaca 84000
caagctatta agtattatat ggttggacag ttaatgaatc agcttaatcg agaggtggaa 84060
gatgttaaat tacagcaacg tagaattcaa tcgcaattat acttaaagta tgttgcggac 84120
gctaaattaa ttgctttgaa taatggcaag aaacctactg aggggctaat taatgcggca 84180
attaattcag atgatacctt tattgacatt tgtagctctc ttaatgaatt acaggcgaat 84240
gctgagctta tgaaaacctt gtatcgtgca tttgaacaac gtaaggattt aatgcaatct 84300
ttatctgctc aaaagagagt agaatataat attggaagta attcttaaaa tgtctttact 84360
tactccgtat aatgtgttat acttgtataa aataaagaaa gaggtaattt tccgtggact 84420
ttgaaaaaat gttaaagcaa caactaaagg aaacttcaaa tactgaaaca ctgactcgta 84480
agaatgatat ggtagaactt aagaaaaata aagatgcaca tgttcggatt gtacctttag 84540
gcccagataa gtggtttgct aaccaatatc gtcaagtgtt tgtaactttg caccgaaaag 84600
ataatacaga ctttagtaca tttttattct tttcagcaga tgatgataaa gaagataaac 84660
tattaaattt agttaaagct attgttgaat ttaacagtaa gatgagtgct aagtataaga 84720
aggcaaatga taaaattttt ccggatgcag ttaagttaaa taatggtaag tataacgcac 84780
gaattcaaca gcgttatgaa atggtagcta ttaacttact gggtaaggac tttgaccaag 84840
aaactgctaa cggtcgtcca gtattccgaa acttatcagt gagtcgttca gtatacaata 84900
gtttattgac ggcaatggca acttatagca tgggtcgggg aaagaagttt ccaacgcctt 84960
taggtcttgt tgataaggat tactcattcc caattgagat ttcatttgac caaagtgctg 85020
ttaactatga tgttagtgtt cgtgctgata tgttaattga agagtcatta ccagacgatt 85080
acttagatgt agacgaagac ggtaattatc tatatattga tgacccttac aagttcactc 85140
aacctactaa ggatgcagac agtgattttt atgaacgtgc ttacaaagaa cttaaagaac 85200
gttttgaaac agaatctaaa gcatatgtta aggctatgag tgaaggcaat ccttatgtat 85260
cggatggttt taatggtaat gttaatgctg aaaaggatga tgaaattagc attaaggatg 85320
aagaccttcc attctcagac accacgaaag aaccaaagga accaaccgat agtgtagatg 85380
aagacccatt cgaaaagaaa gatactagtt ctgatgatac agtttcagat actaagcaag 85440
aagatgctga cggttctgtt tcaactaaag atattgaaaa catgacacct gaacagcttc 85500
ttaaatcttt agacttataa aaaataatag atattatggc tctggtctac tttgggccag 85560
agctatttta atgctgattt tgtaaattaa gagggggaca aaatatagtg gaatcaaaca 85620
atgatttaat tgctagttta gttaaggaag atagtcgttt tgagacgttt gctgatacgg 85680
atgtcgctga aactaaagat tggttgccaa cccttgtgcc tgcaattgac aatgttatgt 85740
tagggggaat cccgttaacg ggtagaatta ctgaggtatt tggtgagcca agtgttggta 85800
agtctactat ggtaggtaat ctaattgggg ttgctcaacg tatgggaatt atcccaattt 85860
attttgatat tgaaggaaca acttcacgga ctcgattaga agatttagga gtagataccg 85920
cacatattct aactttaaag cctgaaaaga aacgtgatgg cacaattacc cctgttacca 85980
ttgaagatgt ttttaaatat atgattagca ctttagctaa gattcataaa gctcgaccta 86040
atcagattgt attatttatt tgggatacgg tcgctatgac tatgagtaat tttgtagcta 86100
accaagatgt tggagaccaa tcagttggta atcaggctcg tgcacttact gagggtgttc 86160
gtaagcttaa tgctaacttg attgctaaca acgggtgtgt aattgcctta aatcaaatgc 86220
gggctgatat tggtggcaat cctatgtatg ctaaagctaa aacagttggt ggcaagggtt 86280
gggaacatga acttagttta cgcttatata tgactcgtaa tggaaaggtt acgcctaatt 86340
ctagcgacac gacagaaatt ggtcatggat ttaagttagc ttttaagaag tctaaagttg 86400
gcgaaaatga tggtgcagtt gctaatgggt atttacttca agagtccggg gttgatattt 86460
actataatac ctttatgggt gctaaagaag caggacttat taaagcaggt ggtgcatacc 86520
aaaagtatgt tgttttatcc ggagacaata aaggtgagat tattagtaaa acaaccaagg 86580
attggcctga ttatttgcgt tctgatgaag gttatcctgt atttaaggaa atgtggcagt 86640
atctattaaa gaaagaattt cctgaatgtt atcctgcttt atttaatagt aatgctaaaa 86700
ttactgttga agaatttcca ttcactgagg gtatgcagga atactatatt cttaagcaag 86760
aaagtcttgt tcataagaat atgaattacc gtatgtggaa aaaggataat gaaaatgtag 86820
tcaagaaagt tctaaaggat tttactaagg aagctaaaac taagaaagct tctgtatccg 86880
atgataaggg agataagaat taggtatggc acgcagagac tatcacacaa gagaaatgcg 86940
ggaatacgtt atgagcactt taggtaacca tagaccacca cggaacacac cagaaattcc 87000
aattggaatt caagatgtac ggaatagatt tcaacgttcc ttagaacgag gagaccgagt 87060
tattgtatct aagcatatct ataatgaccc tcagagtagt gttgtagtta ctttggataa 87120
gtgttacaac cgattcgttt taggacacac gactaatcgc ttaaatggtg agcatatccc 87180
ttatacaatt aattacttta tgctatttga taaaaactca aagtatgtta ttaaaattga 87240
gggtgagtct gaacgaggat atgttgagac taattagtca tataaattaa tagctattta 87300
aataaaaaag aacttttagt gtataataaa ggtaataata catgtgaaag ttcttttttt 87360
gtttggggga aaataaatgg ctaaaaatat tatcggatat aattctaaag acagcaacac 87420
ttttaattca attggaaact actacggaga taatttgaat tctgttggtt ttgttaaaga 87480
cccagaaaaa ttactatatc agtatgataa cttaattagg aaagagggac gaaaatacgc 87540
gtataaattt tcacgtaaag aagacagaga agacttgttt tcttatgtta aagacgcgtt 87600
catctcttta gttaatgagt atgaccctta ctctggtgtt gactttccgg gttatattaa 87660
gaaaatgtta gattatagag ttaaatattc ttatgtaaaa atgcgacaag gtaaagatac 87720
aagaactgta ctgctaaaac aagacgaaac tgacgtatca gaggtgcttg attttattga 87780
atcctcaaaa gggagaagct tttccaatcg tcaaggtgtc gtgcaatacg aatctaatct 87840
tgacgaaatt gatattagct tattagagat atatgaacag ttagaccaac aaaagccttt 87900
agatgaacta gatattttaa ttcttagata tttagaaaca ggagactcaa ctcttaataa 87960
cttaattaag tatgttaaaa atagaggtag ctatactgca aaggatattc ggtatcatca 88020
tacagagtta aaatatcgta ttgctaagtt atatgggaat gattatatta ataactagat 88080
attaacgaac ggacaaaaat ataggaaaaa taaaggaggt cacgatatga gtgacaagtt 88140
agatttaaaa acagtaacaa tggatgattt aaatggtggt tacattactt ttagtcgatt 88200
aagcggttct ggtgatgttt tctataatcg gagtagaggg taccatcatg catttaagat 88260
tgaagacaat aaggcatatg attacaccat ggatgataaa ggtaagctgg ttcaagacac 88320
taagcctatt gtatctttag aagatattaa ggttccagac cctaaagacc caactaagca 88380
ggtaacagtt ccgggtgtac gatatattgc taagagatat aaccaagacc cttatgttct 88440
tcacgatgaa gttcaagagt ctaagattat tggagaccgg ccagcagtag cgtttctaag 88500
tgccttaaag ctatatattc aaagcttaca attctttgct tatgatagtt atgttgcatc 88560
tgaaacagga ctattaggag atttttataa gactggtgac ccagttactc ctactacaac 88620
cacgacaact actacaagta caactaagaa accaacgaca accactacga caacgacaac 88680
tactagcacg actactaaga gtcagacgga ttctgcacaa actgattcag gtaaaacggc 88740
ttaggagggt gattgatagt gacgtatagt aagacagttt ggcattctgg ggacgttatt 88800
gcaaccaact taatgaataa tattgaggaa ggaatttata gttctttgga aacgcgtgtt 88860
gattattggg gtgccgtagg cgataataaa actgatgaca cacaagctat tcagaaggct 88920
ttagattatg ttaaagataa tggtggagga actgtttggg taccttccgg aacgtattta 88980
atcactgcgt caattaagat ttatcctaat gttagtttga aaggcgcggg tatggagaca 89040
accatattcc accaaacgtc ccaagaagca catgttgctg gaacggatat tagcaacgta 89100
acgattaaag atattagttt taacggtaat ggtagtgata ccggaaccgg tggacttatt 89160
tttggaagag aaaataatac aacaacagaa tctttaacta ttgagaatgt tgctattaat 89220
aaggcagggt atggtattaa tgtatcaatt ccaattacga gtagttttac taacgtccgg 89280
gtagttgatg ttgggggtga ctgttttagt ttatatggtg gtggaactag tacaacccta 89340
actaattgtt atgcgctatc ttgtagaaaa gtaggattta atctgagcca attacaatat 89400
tccaccctaa tatcttgtgt agctgagtat tgtggaattg gattcttact aacttctagt 89460
tgcaataata tttccttaat tgattgtgga tgtgaagaaa accttccacg ttctgaaaat 89520
aatctgcttg gtgatgatta tgttattgat agtggggtgg gcaatcgatt aatttcttgt 89580
tattcaagaa atgataatca tgccgccgta agcattactg gtggatatgg agtagttgtt 89640
acggggttaa gacacgtagg ttcctctact attggaatct ctactacttc tgatgtaaaa 89700
ggagcaacta ttgtcggtaa cagtgttatg agcccaatta acattgctag tggttcaatt 89760
ctgaatacag ggactacagc agatattccc aatgcaggta tgtatgatgg aatggtttac 89820
tatgatacag accgaggaat cccactgtac tataaagata aaaagtggtt agatgctaca 89880
gggaaggtag ttgttgatac gactacaact actacgacca ctacaagtag caccacagct 89940
aaaagtgaat aattactaaa agaggtcctt aaagggactt ctttttaata catatatata 90000
gggtataata gaaagaagga attatattga agttcattat ggcacaaccc gctttaaaga 90060
aatttgagta ccaagtggga acagcagtta ataatttaga gatgttgggt gtatctccga 90120
atgatataat cttattattt acagaacatg atactcgaat tccaagagag atggaacaaa 90180
aatttggagt tagaaccttt gtttacccag acgatagaga acaggcggcg cttagctata 90240
tcccatcaat tcgcccatat ctgtggtgga agttcttaga atctaatcct gatatgcaaa 90300
aggaagaatt tatgtatcag gacgctgatg tagtttatcg taaaatacct aacctaaaca 90360
ctttgactaa actatctgca aatcactggt atggctcaga tacagaaagc tataccgggc 90420
cagattattt gaattctaag ggaactgatt ttgttgctag actagcaaag ttcctaggca 90480
ttactagtca agatatatgg aactttagag gtcatgctgt gggtgcacaa tggattatta 90540
aaagtcctac gatagattat tggaaagatg tttattacgc aagctttaat ctatatgcgt 90600
gggtacagaa aatagaacac gaatatgatt atgtgcttat taagaatggt ggaactcagc 90660
aatattggtt tcaaatttgg gtatcagaaa tgattgcaga agcttattta tgtgctaagt 90720
acggtattac aacggaaaag aacccagagc ttaatttctc atggtcttcc gatacaattg 90780
atagatatgc ccaaaacaac ttactacatg atgctggaat tacggaagat gttgctaaag 90840
aaaagcattt attcttcaaa ggggaaagaa agtatgatat tgtttcacct tttgatgaag 90900
atttaagcta cgttaatcca aactactgtt cttatatgta cgcttactgg attaatcaag 90960
caaaacctag atttagacaa taaagacctg agggtctttt ttatttttct attgtaaagc 91020
tataactttt gtcatataat tagtacataa aacaagaaga ggtaagtaag catgaatact 91080
aatgggtatc agactaagga atttactaag ctaaatgaag ctgtagggtg gtttaagaat 91140
aaagggtata cttggtacac gaatacccta gaagacccag aaaaggctgt taagggcctt 91200
ttagagagtt taaaattaaa cgataaaaat aaaaagaata aaagtgaaaa cttggatatt 91260
attgttggaa catacaaaga aaccaattta atttattaca aatattagtt aaataggggg 91320
catatcaata tgacaaataa ctcaaataaa aagataaatg tattcgtaag tcaatcccta 91380
gatgctcaac tagcatgggg ggtgtttgat actaacactc attatgatat ttatttacac 91440
atgggcattc cttatggaga tgttatcaaa caaatagcta aaaatacggg tgattatgaa 91500
atggttatta taatcgggta ctctttaaaa gataagcatg agtatctagc aatgaaagaa 91560
gccctgagtg accagacgat tccaattact tggttaacta ctgaatctaa taaagagtat 91620
aaacgggatt tagaaagcac tagtgtatat aagaaggtgc tagataatag taattcctgt 91680
ttacgaatta tggtaaattg gttaggatta aatgagaatc atcagtatat tttaaatacg 91740
tttgattatt accataatcc cttattcaaa tataacactg aatactctaa gttagcttat 91800
attcataaat tatctaacta tagattgaaa cctgaatact ggttagatgc aaattcaaga 91860
gttaaggatg aattacttag tgatgagtta aaacagtggt ggatatatta tctgaatgat 91920
ttagtagatt atactaataa ggttaaaaac actagtagca aaacactaga atgttttaat 91980
tctaaatact cggctgagga agaactatat cctattttaa aaagtgagga taagccctta 92040
atttatgtta gagcattaaa aaccggaatc tacatgaaag tcatctcaaa agagttggaa 92100
gcacataata tcatgcatca atatcaacaa tctgtctact ttgataattc aaatgacact 92160
tctagggaat atgcaagtag cgggttcaaa cgtgcatcta tttatgatat gctgttagat 92220
tccttaaaac aataaattag attagagttc agtccttgct aagtataact tccctcaaaa 92280
atgtggtata attattaagt aaatgattat attattagaa aagaagggaa gtttttattt 92340
atgtttaatg gcttttggac aacaattatt gcaacagagg ttgtttattt tatcacaatt 92400
atgggtgagt atatctcagt gtcaacagcg tttaaaatga atcaacgatt agctaaagct 92460
agtgacagaa tcccactatc agatgaaatt tttaataagg aacgcttagg ctatctgtta 92520
gagtggttat ttggtgctat tgttatttta ggtatgggat atttcttatc tatgaataat 92580
gtaatcgggt ggacaattta tattttaggt atgcttgttg ggttctttgt tagaaatatt 92640
ctgtactcaa caatcgctaa taagtattac caaaagaaag ttaccaagta tcaagaatct 92700
attatgaata atcaagcttt tccacataaa tcggagtttg aaaatacaga atacggtagt 92760
agtcagcaga agaattttta ggtggtgaat tagttggata ataatttata ttcaggtgaa 92820
aatgattctg tttccgttac ccaaattaga agaggggtta tgatgtcacc ggtagattct 92880
aaaaagcctt tatggattgt agaggaaata ttgaattatc aagaagtctc tatggttgcc 92940
tgctataata ttcaaaaggc atctttgaaa cgttataaac aaactaataa cgctaatatt 93000
ttagttaaat ctggtaaata ctatcgggta aataaagacc ctttcaacaa tttaggtgaa 93060
tctgagttag ctaagattgt tagagcagag tataataaga atagtaaaga caaacaggca 93120
cgagtatata ttccggataa acctattttt attgctcctt taattgtaga tactgatact 93180
tttaatggaa ctttgggggt tgggtttttt gagcgggagc cagttaaacc aactattatt 93240
ggtaataaac aggtatatga acgtggtcgg gcaactggtg tattcttatc tacagataga 93300
atttcatggt tagaaacaaa agttgataaa gctaagctta ttgattcctt aaaacctcaa 93360
attgctagta tgctagacgt tatttacccc gatagcaatg tagggggtag ttccattgag 93420
cagtaaggat gttgataaaa attttttaga gaaaagaatt aagcaagctt tactagacca 93480
acagtatttg tttaagtcct tgggagaatt aggaaactat cgacttattt ttgaaaagac 93540
cgcttttcaa ggaaaactta gagcagatgc tttattattt actgagaaaa agggaattat 93600
aggtattgaa attaagaacg aacatgataa cttaaagaga ctgcctaggc aattaagtta 93660
ttactgtcga atatgtaatt atgtttatgt attttgtcac gattctcatt tagagggtgt 93720
agaagaagtt atacgtaagg gtggttataa aagctatgta gggattatat cttactctgt 93780
ttatatggat gaagttactc ccggtattta taaacaagct aaaaaatccc ctaagtttga 93840
cttacattat gccctgactt tgctatggaa gagcgaaata cgcaatatcc tatcaactta 93900
tgttagacat caatctgagt tagtatcaaa aaaattggat ttgagtcata tgagactatc 93960
ttggaaaagt tttcaagttg ttgctggggg caacgctatg gcttctagga gattaagtta 94020
tcgtcaaata atggctaact atattagtac gtttggcgaa cgtaatggaa ctcttttatt 94080
atgccaaaga tatatttatg cagatatgga ccctcaacat tatttaaaat tatatcattt 94140
tggtgataat ttagaagtac cggaggttgt gggatatgaa gctaaacggc ttaggaagaa 94200
acagtaaatc ctttactgag cataaattct cttattacaa ttttgggttt attactaaaa 94260
taaataacgc gactgaaaag gatattgagc ttagtgagca ttatggcgta gagttagtta 94320
gcagttttca taaagtaatg attcctttaa ttttcttaga aaagggaaaa gaaagctcat 94380
cagttacctc aacagataca gaatactatg tacacattgg taagatgata ttcggtaaac 94440
taactatttc tattcaacgc tacttgcaag gtaataaagt tgtttatatt tacaagtaca 94500
aagatagata taagcgacct aagagcggct cacatttagg taaacgagtg gttaatcgaa 94560
acagagaaaa taatcgaaga agtattaagg aatttaaaga aaaataatat taatagaatt 94620
ggagattttt atatatgatt ggaattggta tttcagacgc agaattagaa cgctatgtta 94680
agagtatggt taatacacca gattttgagg ggtatttcaa taagcttaag tctggtggag 94740
aacgtgcttt ggctgaacga attacttcag caccgcagtt tcttagacta actaaaaaag 94800
gtgctagagg attcatttta gctttaacag aggatttaaa aacagttacc gttagcttat 94860
ataacccaga cactcaacag gttaagtatt ctttagctag ttatccacta aaagatgtat 94920
ataacacctt agaaagctct gataaagctt ctaaggaaga taaatccgat attaaggtga 94980
atacactaga ggacactaaa accactgaga acgcatctaa gacccctaga aagaagcgtc 95040
agtatactaa gcgtaaaacg acttccacta gcccacaaac aaagaaatca tcaactgcaa 95100
cagcaaattc gaataaatag ttagaaaaag tgctttaggg cacttttttt ttattgattt 95160
aatttaattc atatgctata gttagtatat agaaagaggg ataaaaaatg aactataacc 95220
acattaaaga gatgtcagac tcaaaggtac ttgctatcta tttaacaggt agccatttga 95280
ataacacgta tacagatgat tctgattatg actatttagt tattactcat cccaagcttg 95340
aagatgttat ttctaataac aagataaaaa gtcctcatat tcgagtagac ggagatgacg 95400
ttacttatat tgacctgctt aaatttactc ggatgattat taaatgtgtc ccgaataccg 95460
tagaattatt ctataaatat cctgtgtatt atagtagcca gtattctgct atgggtaatt 95520
ggttatttga taatcgggaa tctatcccct atatcaatcc aatgggattt ttaaaaagct 95580
gtcagggact attaaagagt agtttgagta aaatcaatgg tattagtgat gaggatgtta 95640
aacaggcagt gtatgcttat aaatcctatt catatttatc ctcacaagca atattaggta 95700
aatttgttat tgatttacga gagatttatg aatcatttaa aaactcttta attggttccg 95760
atagtagaaa ttcagaagct agagattatt taaatgcttc catggatgag cttgttaata 95820
gtgatgcggt agtctctttt aaaagtaaac gagatacaaa attaaaggat actctttata 95880
gcaaggtaag agacacactt gatttttatc aggaggagtg gtactaatgg atattagtag 95940
tcagctaaca gaaagtccgg gcttaattgc tcttattgat aatcccacag aaggggattt 96000
gttaaaagta atctattctg aaaatatttt agatagtatt attagagatt taccagataa 96060
atgtattatt ccagaagtag caactattgc tctttgtcta tcaaaggagt ggagtaaaga 96120
tagtctaact atttggtttg ataagttttt cccacatgta ttaccagaag accaattaaa 96180
ggtcttaaag tcaatttata aatacttgcc cagtatgggt ggttgggtgg ataaaaatat 96240
tgatttattt atagatttat ttagtcatat tgataaccct agtgaggaac ttattgatta 96300
ttacctaact atatgtatta gaaatggata tttggggatt ggggatgaca acttccctga 96360
cccggatatt cctcgctatc atattattga ttcagcacta acaagtaatc ttgtagggag 96420
acttagtgat agccaacaaa agaaaatcat aaatctactc acgaatcgtc cctatgtcaa 96480
tatagattta agaccccaca ttccctatag aagtggttct ttaaaatcat tctataaaga 96540
ttgggataaa ttcattacca ataaagcaat ttatgaagaa ggaaaaaatc agattgacct 96600
gattgtaaaa gaaatgcagg actatcggga aaaggaaacc aaaatcaaga atagccctaa 96660
agtaactcac tggtggcaaa agcttctttg gaagtaggat aggggagtaa taataatggg 96720
cgttattagt cagctatcag aaattcggga taatcaagat taggagattt tactgtggat 96780
aaagaagagt ttgataaaat catggatgag ctagggatac ctaaagggaa tattaaaaca 96840
atttatgctt gtcctttctg taattcagac gagtatttaa tgtcctctga tggggactct 96900
atggcctatt ttcccgaaag ttatgagaat aatattttag ttaagtttaa tactattaag 96960
cgtaaagaca cacgagactt atactcaata acagcaggat ttaaaattaa gtattgccca 97020
atgtgtggca gaaagctggt ataaattatg aaaaactgtc ctttttgcaa tattaataat 97080
tcaagtgggt tacctgaaaa gtccttattt ttagaacatt atgactataa gcaaatttac 97140
gcaattggtt caagcgtcca aaaggactgg gatggaaacc ctactttaac tatttggact 97200
tccttaccac gtttaggggt tcaagatgaa tttgaaatta aatattgccc tatgtgtggt 97260
agaaagttat aattagataa aatagaaagg gtgagtcaaa tatgtatacg ggtgttgaaa 97320
atgatttaga taagcttgtt actgcgggtc ttgttagtga atggcattgg gaagcagata 97380
agttaatagt atttgttgat gataacatgt gggaagaatt taaagaggtt actgacggat 97440
tatttgattt agatgatacc ggccttaaag catacattaa gaatgattat atttgcctag 97500
aattaagccc agaagacgac ttcattttat aagaggacgt aagcatggat aaaaatatgt 97560
cagattcaat tgttaggtac aataagccta aagttaataa gggtaaagct attagggcta 97620
aagcccaaca aaatataaaa gcattattac aatacaaatt aagtaagcct aaaaaccaag 97680
ggtatgctgt attaaacaca actgaaatta tggctatcac tacccctttg atgtgttact 97740
actcagactt agatggtaag gtacgcagtg atgaagatat tattaaagat attttaggca 97800
ctactgatga tttgatgact gctccgattc acgttattcc taattatgga agctatcaac 97860
gtattgaaaa agagcttgtg ttgtcaaaag acattagcgt taaaatgtta ttctattctt 97920
acattaaaac aacagataca aaacttattt atccaggaga aacgggagct gttgggtctt 97980
ctatacacaa aataattgca tataaggtta cctcagatat aaagactaat gagttagtat 98040
ttagaaaagc tttggcgttt atagacaaag atatttatca agggtttaga cgctataatc 98100
agagaggata taagcatgga aactaaaatt aaaacattgt ccccacttaa tcgggttatt 98160
aaagaaaact atttagttca aagcaactac acatttaaag ttagtcatga aacttatagt 98220
gaagttgtaa cagtaccatt aaagaataag ttagaagttt atcaatggga taagagtgaa 98280
cctcagaata aaaatgacca tcgtccaatt gatttacatt tggctgtagc agataatgac 98340
ttttcctatc aagcatcgta tttagaacta caacaatttg atgattattt ggatagttta 98400
caagtagtag atgagtctgt attattagat ggcgcaaagg attttcatat taaagttggt 98460
gtagaaacta ctcgaacaac ttataagatt aaagatacta atttaattaa gttcacttat 98520
gaagatgcta acggaggtat tattagactc ctattcgcaa gttctcctag tgaccaattc 98580
ttactagact tcacgcaata taaattaaat atgagtaatc tatatgcaat tcttgaccta 98640
atggctaatg gactgtttgg ctacttccaa ggatttaatt tcagattaaa ggataattca 98700
agccttgaaa aaagttattc agtgatgcta aattctaggg agactctacg tagattagtg 98760
tttaaacccc aaaaggataa ctttattatg ctaacgactg accgaactac tttgtcaatt 98820
cgtatggcag atattgaaaa tattgctttt actttaccgt ctttagaaac tggattagat 98880
tcagtatatc tagggctaga agtcaaagga aaaggttata tctatttatg gttaggttac 98940
taattcaaac tcagtcaaga caatttttat atcacatttt agtgtagtat tttatacaaa 99000
tattctttat aatccataaa tatactgaat atatcttatt ttattcatat aaattataga 99060
ttaaaaaacc acatttattg gctatagttg ttgtcatatc aacaatcaac aaaattaatt 99120
caacattatt ctgctttttg aatattgaat aggtgatatt cattatatta ctaactgtag 99180
acgtaaaact acggataatt actaatctta cagggataag tgtataatga aattaaagag 99240
tatacaagta ttcaatatta aaaggagagt gcaaatgttg tatggcaaaa ggaaataatg 99300
ttacactaaa aatgttgtat aagaataagc tggtttatac taaaactatc gctatgattg 99360
atagtgggaa gacttttgat tttattctaa agtatttaga agaagaggaa ttacctattt 99420
cacggggaag tctagctaac cttaaagcta aattaaagga gtctagggag actggtgtgc 99480
cgcttgctga tttaattgac cgtagaaaga agagtagtat tacccaagta agtcctagaa 99540
atatcgaggg ttacaggggt gactctaatg aagttcagca agtagttaaa gtagctaaac 99600
agaattggtg gtctactgac caagttttag atagtattat tactaaaggt gtagatagct 99660
tacagtatat ggatgttatt gatttaccta tgcttctaaa ggctgtggaa atgaaagata 99720
ggaaccatgc atctgatagc cacgggttaa gcttagaagc catgaaacag tatcagctaa 99780
ttatgcaagc tcaagcagaa gccttagcta aagttcttat gagttatgtg ccagaagata 99840
aacaggcaga agcttggaaa gaattggata agcaacaagc agaaattcta aaagatgtta 99900
aattaagtcc agaaggtaag aaattaatct tatctctaca aaaggaaggt attaatattg 99960
actaaaaata ttaaagaaat tatttcaggt tataaatcta acttacaaca tgcaactgtt 100020
acgcgagaac aaactatgac ctacacaatg acagcaaaag taggttctga aaaaagcatg 100080
ctttttttca actttaattc tcagatgtta actgttaaat caggtaagct aacttatgcc 100140
gttatgttac ccgcagatac attttctaaa gtagatttaa ctgatgggga tgctttaaat 100200
gcagtattag ataatctgac gttcttatta gattcttctt acgattatga catgcacatc 100260
tttgactacc acaaatgctt gtctgatgtg tcttcaattg ttacagataa ggaggatacg 100320
cttaaaggta agttactatc aaccctttca agtaaagagt tatctagcaa gaaagagtat 100380
ctaaatactt tggttacttt cgcagaaaag aaccattata cgtatggata taaattcgtt 100440
gattgtggtt taagttatag tgacgatgta attatttggt cacaagcttt ggttatgcta 100500
cagtcattct tacgtgaacg gagactactt gatggattag ctaaccttgg gtaaagtata 100560
atagagggtg accaccctac tagtagcaaa acgctggaac actattagca aaatgccaga 100620
acgaagtata ttaaaaataa gattatttta ctagtagcaa aacgccagag cactagtagc 100680
aaaacgctgg aacaaatatt taaaaatact gtagagacta ttaataacta atccctacag 100740
tatttttgta tagttattaa aaaatattct ggacccttga cagggacctt atctcgtgta 100800
tactagaatt atcaaataaa gagaagggaa gcacaaaaat gaaactattt aaatatgatt 100860
tatcagctaa aggtaagagc aataccaaga acgatactaa tagcttcacg tatatgcaac 100920
ttcgcgactg ggtatatgat gttttagata atagggagtt taaacctcaa ccaattactc 100980
tagcccacct aactaagact aaaggcagta gtcccgatgt gtatacgagt aactttgaca 101040
tttataaagt agggttaggc ttatataact actatagtaa gggaacgagc attcaattat 101100
acggtgatac ggataaaaat attttattga gattaggcct tgacaagtac ctgtatatag 101160
attattatac aggtgaggtg ttggaagaaa tcagtagaag tgaagtagag aaaaaagttc 101220
ctgtacaaaa atggaattta gaaagtgaga tgtacaaaca ggcagttaaa atgtttacta 101280
gcaatttaaa taataagaaa ggggttggaa gccatggcaa ttcatgaacg acccgataat 101340
aaacctaaag accggcaggg ggctaatgat aagcgaaata gaaatatcgt tattaaaaga 101400
attattttat ggatggtggt tattgggata gtaattaagt tttggaattt cttcgtttat 101460
gtagggacaa caagtatttt actattcttt acaggtgtag gaatcacttg gttcttatgg 101520
tatctagcat acacacaatt ttatgataat cgtaggaggt aaaaacaaat ggaatacgaa 101580
atcgcaaaca gttatgattt agcaaagaca ttaaaagagt gccgaatcaa tcagggaatc 101640
actcaaacgg aaatggcact aaaatcagat tttagacaac cacaactatc atcaattgaa 101700
aagggcgacc ggcaactctt agtggatacg ctacttaaat atctggataa catcaatggt 101760
catctttata tcaagatttg atagttaaca tttaatatta gaaagaggtt attaaaatga 101820
ttaaagaaaa atattctagt gaaattattg actataccgc aagtctacta aaagactggt 101880
taaaagtcta ttcaagtgct gatgacttta tggaaaatga actactatct tccggttact 101940
taatcagtca aactgatggg gtggacgtac tgtataccga tggtgatgaa aataaaacgg 102000
tatcagagca actgctagac tatctaactt ataatgtacc aagtgaagaa ctgacaggcg 102060
atggactact cgatatggta gatgattttt tcgctaacgc tgtaattgcc tatattttag 102120
aagatgatga aattgtggta tataatctaa aataagtgtt gacaagttat tctatacttg 102180
atatactaag tatgtaataa agatatggaa agggagtttt aaagatggca gaaacagaat 102240
tgattttaaa gggtgttgac ctagacaggg gttctgaatt atttgacgta attcataagg 102300
cagacggtga cacgctgtat aaaaaatcca gcctacattt agtcatcaaa aagagcacag 102360
ttaaaaatta tacagatgat aaaatcatta ttcacaactt ttataacatc ttttataata 102420
atccagataa tggaattatc gttgattttc gggtaaacaa tgggagcaaa gattctgttt 102480
ggtataatcc tcaaattatg ctagacgcta tgcagtatac cggtagctat caaaacgtaa 102540
gacagtttaa cactaatctg attcatatgg gacatgcaca gaaagagctt aaccaagtta 102600
tggacttgct agactcttta gggtttaagc tagtcatgga taagtatatg tgggacgcaa 102660
tgaattaata taaattcgaa atttagtatt gacaaggtat tcttttaatg ttatacttga 102720
ttcatagata agggaaggaa gttttaaaaa tgacagcaag cgaaaagtta caaaaattaa 102780
tggataatga tgaacttacc gaaagccaac aagatagcct tatggattat aatgtttatc 102840
aagttgataa cgcacgggac ttatttaagg aaatgcttaa cgaaaatact agccctttta 102900
gtagagaggt tactaatggc ttatctgatg cagatattat tacaaccctt tacaacttat 102960
taaagtattc tagtgttgac tatgttgttt gtgacggtta taatggaact gttgagctat 103020
tagatgatga tactttagaa gatattcttg atgtagaata gttaaaatag ttgttgacaa 103080
gatattcaaa tgatggtata cttaactcat aaataagaaa aggaagtttt aaaaatgaca 103140
acaaatacaa aggtagcttt aaatgaattg acggaaaatg atactgcaag actatttgaa 103200
aattctaaag tttgggaaaa ggttactagt gaatttagca atgacgtttc tgtgatgtta 103260
aatgatttta tttcagaact aaaggggtta ggtaattata gtattaataa tagcagcgac 103320
caatataatt gtttgtatgt agacaaccct tattacttct taagcagttt aaaacgtgct 103380
tgcggttact atgctgttgt attgtctgat gaacaactta ataaagctag tgaattggtt 103440
tcggaatatg aaaatagtgt aaataacgac caacaggaaa agctaacgga agatatgttt 103500
aacttatcca atgagtatgc agaaatgtta ttagattcca tggtggcgga atacgatgct 103560
atctataata aagatgagtt aaaagaatac atgcaagatg agttaccaga aatgtacccg 103620
gacggtgctt actataatcg tgaagataat tcaattcact acatgattaa agactaataa 103680
aaggggtgta taaactatga aactatctgc taaagatgtt gaagccatta tcaaagattc 103740
taattataag aaccaacaag aaattgaaga aagttacgac tgtggttcac tagatatata 103800
cttaaatgaa tcatcagcta aaaaagatat tggtgggaat cgtgaatact cccaattaga 103860
aaagactttg cttcctagta aaaaggttgt tatctattac gattaatatc aaatttgttg 103920
ttgacaagtt attcaatcaa tgttatactt aactcatagt aaagagagga agttattaaa 103980
atgtatcaag ttaaagtgtt tgttggtact catacattag agcaggatat taattcatgg 104040
ttagagaaaa atatggcaat tgaattaatg gatattaaat ataatattga tagcgatgga 104100
actaatgact atgctttgat tatttacaag aagtaataag ggggttgcta aaatgttaga 104160
gaataaagtt aaaaacgaag acttgctaaa aattgctaat agtttaaaag atgaaatggg 104220
tgcggataag ctattaagtg ccttaatgaa tgaaatgcgt ccggaagagt tgcaaactta 104280
tttagcaatc attagtgact attattatat gggtatgctg gaagattaat tttaaaaagg 104340
agatatatta aaatggcatc atatttaaaa gtaaaagacg ttttaaccgt tgccttacaa 104400
gatgataata gctcaatttt cggtggtact gcttttccta atgaaactgt agcggatttt 104460
atgcaatgtg tagagtatac cgatatgggt gacggtgata ttctaaccct taatagcccg 104520
ttaccagtct taaacagagc tttaattcaa tcaggtattt tacctttgag tgatgagtta 104580
taaaatattt gacatttgac atttgacatt tgacatttgg catttgataa atcttatata 104640
taaaaggggt aagcttatgc gaattgaaga ccatagggaa gctaaagcac agaaagacgt 104700
ataccaagtt ggaaatatta ttaaaaatgg tgtagattat ttcctagttt gtaggtatcg 104760
tattgctaag gggttctgtc tagttaattt aagaaatgat aaattgttta attccacccc 104820
ctataagact ttagacatgt tagctttcgg ctatattaat ccagatgatg aactagtaaa 104880
gggtaaaatt gacttatctt atctaattcc cgaaaaacct atttcaaata aagacttgta 104940
tcaagtcgga aatatcattg aatacgtaaa tacagatgag tttgatggtc aaggttacta 105000
tctagtatgt agtaccctat tagataaaca gtatgcttta gttaatgttc gaacatctac 105060
tattatcggt acttataatt ctttgcaaga aatgattatt cgtattgcaa tgcctacgaa 105120
ctcattagta cgaggtaagc tagttctgga agattaaata ataactacta gtctatagat 105180
tacttaagta tagagcttat tatatagctt gggtagtcta tttttgtttg tgctaagcat 105240
tagtagtata tatagatagg tatctaattc gtatatacag aatcatacag ataagctagt 105300
ttttgattaa aagtaaaagt atttagtcta aagtatacta agggagcata agagcataag 105360
gttataagag taggctttga gtataaagag atataaggct ggactactta actataatag 105420
ggtaggttga actaagtaat caaatatata aatagatatt gatagatact agacttatta 105480
ggtagattat attaattcaa tagactatga tataagaagt aggaacataa atcctaatac 105540
ttagcttagt acctataaga gatacttagc ttaataatta actacttgac tacttgggta 105600
ctcaacttaa cctagtaggg agataaaaaa gtaagatata agagtaagat acctaactta 105660
ataattaact acttgattac ttgggtactc aacttaacct aatacttaaa ataagaaata 105720
gaaaacaaag aagaacaaaa taaaacaagt acctagggta ccccttgcta gtgtggtaaa 105780
aaaaccacta ttagcaagtt ggtcacttag ttactcaact aactaaccta atacagataa 105840
atgtatttag gtatattcct taataacctt gacataaagg catttgtata ctatactata 105900
cagtatagag gtaaaattag gttagttaca tgactaacta acctatatta ttttaaagta 105960
tttcagaaag taccttgaca tagtatgtat actacggtat aattatctat gtaaggtaat 106020
aaataagtat tgactaacaa agggggaact ataaacatga gtatgaaaaa taatcgaaca 106080
ttactggtag gcagtgaact agctaatact cccaagatta gcttatcaag cctagttaat 106140
gagttagatg tagctattaa atatatgaag cctagcgtac aagagttagt ggactattgg 106200
gtgtctaaag ggaacaaagt tatctttatt cgtgtaggga cgactagcta caagctacag 106260
gtattagact atgtggctga actatcaaga ctagagtata aagataatga aaaaacaagc 106320
actactttac ttagtagtat gacaactggt aatcatggat ttattactta tgaatcagag 106380
ctaattacca tcgttttaaa cgagattatg gatatttggt aaaattatag atataccaat 106440
taggttttag gtaccttagt ttaatttttt tacgtaagat tcatatatag gagacaatgc 106500
ttttttaaaa acaaatgccc ttatatcagc attcttgatt ttagggtgca aaagtaaggt 106560
taatgtatac caatttattt ttatctgctt atggttgact taagcagggt aaccggctat 106620
aataaaatag atataaactt atataaatac ttaaaagggc tgtaaaaagt aattaaacgt 106680
acttaattta gcttataagg gagtttaaat gcaatctaaa gtatttatac ctaaatgaat 106740
taaaacggct tagaacggat tatatgagct tataaagtaa tactaaatta gttgttgact 106800
tactaaggtt acttatgata tactaattaa gagtaacgat aacaaagcac catagtatca 106860
aagcagaata gaagatatta agtagttagc tatatagtgt agttagctac tttttattta 106920
tttaaaataa tgcttgactt agtattcaaa ttagtatata ctaagcagtg taataaaggt 106980
tagcaagtta aggactaaag aactaataag tatcaaataa agttaaatta gttcttgact 107040
aactattcaa atgatgatat actaagtatg taataaagaa aggacgtaac taatatgaaa 107100
actacaaaac agtatttaac caaccacagc tatttaaatt gtaaacaaat taccactgct 107160
attaaccgtg cgactacagg attaatcaat aaggctagtc gtgggggact atatgaaaac 107220
tttggtcaag tagaggttcg tagcattaaa gataagttta ttgatatttc cgactattcg 107280
gaaaatatga ataacaaccg tgatgagtta ttaatgttta gtcactggtg cagtaattac 107340
caaggataaa tttaaaataa gtattgacaa agtattcaaa tgatgatata cttaattcat 107400
ggtaaaggaa agggagtttt atagatgttt aaagtagtga ccagtttaaa tgagggcgtg 107460
aaagataccg tacaaagttt cattactttg gataatattc ctattatgga gcttcccgaa 107520
gtttataagc cggacaacaa agaagattat actttgctat ggaaaaatgg ggtaattgat 107580
tttatgctgg aacagggtga aaatgaaata tataagcacg ggtatatcca ccctatcatt 107640
atccctgttg agggtaacta caaattaatg caggaatatc ataaagaaat gcttgacaga 107700
ctattcaact gatgatatac ttagtatgta ataaagaaag ggaaaggaag ttttaaagat 107760
gattaagaaa aactatttag aaattgatac tgatgtacgg ggcaatgagg tctatactaa 107820
aaagactaat gaaagcttac caatgtactt aggaacaatg aagttaatca atggtatctg 107880
gaatctagta agcgctgatg aaagcggaaa tgttgtagcg gttgaatatg aaactactgc 107940
actgggcact ctgaacgctt taaatgatga acttaagtct attagcattg aaaatgtaca 108000
aaaattaaat gattttaaca ctgctaatat tggtaacatt cttgcctttg tagaataaga 108060
ctatataaaa aagggagtat gattaattat gaaaaattta gataaagatg aactgatgga 108120
aattgccgaa aagttagaag ctgaaatggg tcaacatgat ttattactag caatcctatt 108180
agcaacgcct agtgacgagc tacaattaac tttagaatat attaaccgct gttatgaagt 108240
cggagtaaaa ggtatctaag tattaaaatt agttcttgac taactattca aaagatgata 108300
taataatcac agttaagaaa gggagtttta taaatgttaa ataaaacaaa ggaatcacaa 108360
ggattatttc cagatgagtt cgaccgtatt cggttatggt ctaaagacca caatgaaagt 108420
gcatatggaa aagatgaaaa tggggaacta actattttca gctaccggga taatgatggt 108480
ggcctagatg ttaagcagta cctcaatgac tctgaatggc gattaaatac ttactcaaag 108540
tcgggtactc ttctaactac agattacgga aaagacttac cagaataaaa aagttattga 108600
cttagtattc aaatgatgat atactaatca tagttaagaa aggaagttct ataaatgact 108660
acaagtaaat ctacagatac aaactttatt gttcaactag ctacggattc agatacttat 108720
attcagtatg attatctaac tgaaagtaat ccatttagct tagttaactt aaatggtgct 108780
actatgttta ctgcaaccag ttgggataag gttcgcggta atatgcctaa atactctgaa 108840
aacaatccaa tgtttatcaa agattaatta aattagttct tgacttacta ttcaatcaat 108900
gatatactta ttatagttaa gaaaggaagt tactaaaatg acaagtaaat ttacagaaga 108960
acaacgagaa aaggctatgt actttttaat gaataatgac ggtttgaata ttatgcaact 109020
taaagaattt atggccgttt atgaaccgta tgagattgcc aagatggttg attgggcaga 109080
tttaaaacta gattgtgatt atattagaat aaccgattat tattcagaaa cacaagaagc 109140
taacacagca tatgatctca tttctgatga agaaattgaa gaagccctag agcaattgca 109200
gtaaggggat agttataaat cttaaattag ttcttgactc actattcaaa taatgatata 109260
cttatcacag taaagaaagg gagttttaca gatgactgat aaatttacag aagaagaaat 109320
tgataaggca attgaattta tggtagataa tggcgatttg gatattatgc cacttgaaga 109380
gtttatgact agtttcgaac catatgaaat tgctaaaatg gtcaagttag ctggtctaaa 109440
tttagactat aattatattc gggtaaatac ttactatgaa gatacacaag aagcagacac 109500
atcggacgaa ctaatttctg ataaagagat tgaagaagct ttaaatgagt tacaatagag 109560
ggggtattct tatgactaaa ttagatacag aaaaactaat aaatgaaact aacgatgatg 109620
aaattgcttg tatgctttat aatattgaaa cgtataagga tattaatgac tatactcact 109680
atactaacaa tgatgaaaat gacttaaaag aattgcaaga agatggctgg gtgttggata 109740
ttacaccggg aacatataac ggggcattag ataaaacgga ctatagcgag ttaaccactg 109800
caaacattta tagtgtttta cttgaagatg tttacgaaga gggtttccaa gagttgcttg 109860
aagacgtgta tgaagaacct aacgcaaggg aagcccggca ggttcgctta ttaacggaat 109920
tttataacgt gtttaccatt gggcaacact tatatatcga ttatgattag tagaatataa 109980
gcaaatgggt ctagctatat agctaagcct tttttatttg tttaaaataa gggttgactc 110040
aatattcaat caatgttata cttagtatgt aataaagata aaggaggtta agaaagcaga 110100
atacggattc aaggttacat agtcgaagcc taaactagat atatttagag tagaataaaa 110160
tacttttata aaaaggtgca gacttcccta atcatatctg gtacggtttg accatttacc 110220
ggtgttcctt acttatctat aatcctatta tacaattctt tatatagtct gtcaatagct 110280
aatggtaaat taatttaatt agtcttaaaa atagcttcta acgtgtttta agcatattag 110340
gtataattaa tccagataca gcttaaaacg tcttacataa gcttacagac accttagaat 110400
ggattctgtg gggtatttac ctattaagaa taatatttat taaattagct attgacttag 110460
cttaatctta gctgtatagt aataagcata gatgatactt ggtacacaat aacaattggt 110520
agtcttatga taacggacta cctatacata ttagaaatta taaaataagg gttgacttag 110580
tattcaactg atgttatact tgattcataa ataagaaaag gaagtcttta taatgactaa 110640
attaaatagt cgtgtagtcc gcttaacaac tggtatggta tttaacttaa aggaagaatc 110700
aattagtctt accggctgtg cttatgcagg gtgcaaagta accattaaag atattgaact 110760
gttttcagat agtttccttg gatttgctgg tcaaatgaat cagttagcag acacttactt 110820
aaatgattct gacttagcta gtgccatctg gaataatata ctggagttac ttatcaatgt 110880
agaatacggt ggtttagagg gagtcagctt ttcctaataa tatttaaata gttcttgaca 110940
aagtattcaa tagatgttat aattgattca tagataaggg aaaggaagtt actataatga 111000
ctgatacaga aacgttaaca actgcaattg aatatgtaaa gaccatgaaa cactatgaaa 111060
cccgcttaca gtttcttttg ggaaaggcta ttgatggggg tactttacag tatacttgta 111120
ctattgataa ttgcgaatac tatgctaagt ttgtatgtga aactattaag tcaagcaagg 111180
taaaccctga tgggaatatc gaacatttat gccacacgtc agttaatatg attacagaaa 111240
ctaattttat gaaaaccggt ttgcagattg tttcaattaa gtctatatag aaaggaagtt 111300
cttaataatg acaccaaaca aatttacagt actacagcaa gcggatgcac aggaatggtt 111360
agagaaccat agttttgtat atattactac accagaagaa ttaatcaaat cacagacacc 111420
tagcgaatta gctaagatta tcaagcaatc tgatttatct ttactatgtg aatatattcg 111480
ggtcggatat tactattata attataaaga agccgacact gtagctgaat tgattactga 111540
tgaagaaata gaagaagctc ttattgaatt aaataaggaa taacggttga cttattataa 111600
ttagtattat ataataggtt tatagataag aaaggggctt tacatatgag tattaattta 111660
ggtactttaa ttgtatttct attagctggt tggggactga ttgacttagt taataaagcc 111720
ataggtctta actggaaacg cgtgttctct gaatggtttg aagactaatt aaaataagtg 111780
ttgactaact attcaactga tgttatactt agtatgtaat aaagaaaggg atgttcttac 111840
ttatgaaatt agattttgtc catattgata agaaagtctg gggtatctgg ggtagtcgta 111900
acggtatcaa atataactat ctaggatata tgagattcga taatacttct aagttatggt 111960
actttatgaa agatgattta gaaagcaaca gacaagactt acagcatacc ttaaaagata 112020
gcgttaaaag cattaagcta attcttaaat agttcttgac taactattca atagatgtta 112080
tacttatcac agttaaggaa aggaagtttt acacatgact aaattagatg aacgagtagc 112140
acaagcaatt gatggtgaag catttgaaca acgggcaagc gtttatattg aagaaattga 112200
caactacgca acggcttact atacggttca ggttgtatat ccacaagaat tagctgatga 112260
tttaggtatc actgatgagc ttaaccagtt agctaaaaaa tatcccgatg atgatacagc 112320
gttatctgat aatgtgtggt acgtggtaag cgattattta actagtcatc cctataatga 112380
gccactatta ggaatcgaat aatatacaat tatctattga caaactattc aaataatgat 112440
atactaatca cagttaagaa agggagtttt aaaaatgact ttagttaatt cgttagtacc 112500
acgggaactt gtaagtatta ctcagcatgg tagctggtat caagttgctt ttatgaatga 112560
aaatgtactt aatacaatta cggcacaagg gattaagaaa actaagcagg caattagata 112620
ctttaatatc gttcatacta aggggacacc gatggtgtta ggtaaagatt tgtatctatc 112680
tacttttatg gactagggag taagctatgc ttaaattaga taatatgatt aagttttata 112740
tacctaaaat ggatagtaac tttcagataa ctaacttata taccgaggtt ggctgtaggt 112800
ttgactcagc acgtcagatt agtatatatg atagctatac tctgcataga agtgaaacaa 112860
ctacttatat agaagaggta aaggttattc agctatctgt taatcagatt acaatgggtg 112920
tattacaaga tatgcaacag cttgttgact atatgtttat ctgggataac catcagtcag 112980
ttagtgttga ggtaaacggg gtgctatatg tactagagaa taccgaagac ttttacgagt 113040
tacaagctga tgtgtttcaa ctcatataaa ggtgcttaca tttaattatg taggtatctt 113100
ttttatatag gggatgtgtt tagctatata atgcttgtaa ggctgtatga gcaattataa 113160
gcgtttctaa tctacttaca tgcgattgtg cttaacgtgt ctgtattgac gtgataggta 113220
gctacattta gctgtatgct attgtatagg ttgatgtaga gtaatatact ttgatgtgga 113280
tagcttagtt atactagtcg cttgcttagc ttattcttac atgatactga tattgataca 113340
catctgtaaa cattacagct tatctaattt aatctgaaat acttttcact ttgattagtg 113400
ttgtctacca ccacagttaa gcttatgttt tatttatatg tacaccccta cccccggtta 113460
atttaccata tagtgcactt taaggtaccc ctattctctc tacctgaggt tccaactaaa 113520
aatatcctga aatttaagtt ttgaatacgg ctaagttgaa cgtgtatata agcgtatgag 113580
tatttcgggt attcctctgg gtaactatgt ctaactatat ctaactacat caaagtatga 113640
ctaacctgag taagtatata agcgtatgag tatttcgggt attcctctgg gtaactatgt 113700
ctaactatat ctaactacat gtcattcgtg ctcctataac ttattatatt aaccaccccc 113760
cccttattta ttttagttta cagtaattag gcatatatga actaccccta ataattccta 113820
aaaaatatat atgtatataa aaaagcatct ataagcttta gatgctctac tgatattaaa 113880
tgtattgtat tattatttac ttgcagatac atacggggct ttttgataac catactcccg 113940
tgtatattct tcatttaatc tataatctaa actcttagag ttatcccagt cgttataagc 114000
ttctaaaatg tcatcttcat ttttaacagt gttatttaga atatcaattg cagattgcgg 114060
agtatctgca caacctagaa tctctaagtc accataatca tctaaatttc gaagtacata 114120
agctacaaac atgatattta cctcctaaat atattattac atagtaaata caacactaat 114180
taatactagc aaactaacag ctaacatacc tttaagaatt ctattgtact ttcgcttttc 114240
tttaatcaaa ctaaccattc ttaacataag taccactcgc tcattatttt catttgaaat 114300
aactaaatag tatttattac gtttattagg gactgactgt aacttatcct cttcccaaat 114360
agcgtttgct tcatcaagtt catgtataag gtacgtatca actaaaatct taacaacatc 114420
atccttagca ttgttgtcaa cttcatcttt atcgtcaatc ttatcaacat cattgtaagt 114480
tgtggttttt gtgcgagtgt actcagtaaa catattttaa ccaccctaac ctttctttaa 114540
ttgtgatacg taatctttta ccctttttgt gggtttatta atgtagttaa ttgcatcggg 114600
attctgttta actgccgcta accgaatctc ttctgatgaa ttaggataat atacaatatt 114660
gtacccatga tgtttaaccg ctttaagcat attttcttct ttaatagctc cccggttgat 114720
tcggtcagaa atatgatagt gctcgtcaag cgcttttaca agttcctcac ttttaggaaa 114780
aattaattct ctaactacct ttaggtcact aacggctata ttagagtcat aaccagacct 114840
agctactgta ccccaccctt caacttttgc gacacgaatt ctgcgaaagt catagtaact 114900
aaagcaatct gctaattttg tacaaaagtg catacccgga gttttaacac tgatgttagt 114960
atcttcatga tagcttttgc caacacagta tagtttatca ttgcggtacc aatcatctcc 115020
aaatacttta taccccttaa tactatcttt ttcactaatg gtttccatac tttaacctct 115080
gatttcagtc cttattttta ttagttgtta aggaagatat acttacctga ccttccttaa 115140
tactattaat tatactttct cgtaacttat caaaattttc atctttagtt aaataccaag 115200
gggctttaaa agttaccgtt aaatccaccg tataatcatc ataattatac ttattttccg 115260
cagaaaaata ttccttctcc aaatcagaat aaccaataat tagctcttta cccgaatata 115320
ctttattcat taaatagcta ctgtccctaa tagaagcaaa taaagtaaag ccatttacac 115380
ataagttaga aagaatacta atatattcgt cttccaattc cggaatacat tttgattcac 115440
aaaatggcct ataatcttct actccgaata gatgattgac tgcagtatat tcagaagata 115500
aataaccact ataataaaag acatagaaat tgtttgaggt tagtctgcct tccttgatta 115560
aggactggca cactaagtat aaagtacagg taaaattcac cccatcaacc ggtaaatctt 115620
tatcatttgc aacatacata atatattgtg ctacttggtc catagatact ttattcatac 115680
ttactattcc cctctaatta aggtctttcc atatttaaag ttttaccatg ttccgctacc 115740
tttgcttgaa actccccatc aggtaaggtt ttaatatact tgattagttc cttatattct 115800
ttacgtgtga acttatattc aggtaatact aaatctactt tatcaatcat atcaatatca 115860
aacggaatgt aagattctgc tttataacag ataactttag aatcgaagcc tttaccacca 115920
ttatcagcaa taataacatt gtattctttt tctcttaaac gttcatcaat cggagtcata 115980
acaaattcat taactaacat ccatagtttg ttactatatg gcaaccggta aaaatcatct 116040
gtatacacca taaaccaata aggtttattc atagacatat tcagtacccg tttattccca 116100
tactttaaga tactattttt acctccgagc atactatcgc tttcctcaaa ggaatattta 116160
ctgcttaact ttttaacttc atcttctagt ttgctatata acattattaa ttacctcttc 116220
cctataagtc taagtccatt cttactagta gaatttaccc ctcatagata ggggctttaa 116280
acttactacg ctcagctaac tctgcaagga gtttaccatt cgttaaagtc ttaatataca 116340
cgattaagtc tttatactca tcgtctgtaa atataaagtc acttaatacc aagtcttctc 116400
cgcaaacttc ttgtaagtaa aaataaaggc cggaagaatt tgactgatga ccccaaacaa 116460
taaaagcatc ctcttcttca gtaactggac taaagataat gttatattta ttagtctcct 116520
gacgttcttc aataggtgtt gcggctagaa gtgccacata cttccaaata tcttcactat 116580
gtggataatc cttaaacttt acagaagctc ttaaatcgta taacctttga gtatcaacgc 116640
aaactaataa accatcccag tgtttagagg tatcatcatc gtcataagta acaataaatg 116700
agtcttcaac tatccgcgca ttatattttt tatcacagtt cttaattgct ttaataacct 116760
cggtatactt cataataaaa catcccttca cttatataat accattacaa atcatatcta 116820
gcaagatata tttaatcaat atcttctaaa tcatcaataa tacctttctt aatatttaat 116880
acggtctgat gtaactcctt ggcactagct tctgggcgtc ccttagtttc ctctgcaatg 116940
ttatataagt agtcttcgat taaatcacgg ataagcaaac ctgcgtcatg caagttatct 117000
aatgcttctt catcttcatc tgtactacca taaaaatcaa cttcaccaac taatttatta 117060
accagttctg aaaggctaaa cataattact ttaccccttt ttattattat tgaatgagtt 117120
ctctcggcca tagaataata cccggaccct caaactcttc taacttctct tcaataccaa 117180
agcttccatc aatatcctca acatcgtcag catacctaca aatttcccaa gcctgagaag 117240
atgttagctc ttcacattta gtgtctggct ctgcatcaat gtctgaaata ttttcataat 117300
aatactttac agcttctttt ttatcctttg cggcaattaa tgcatagaag tctgaaccaa 117360
tatctgggga aaatctaaag tatcgttgaa cgattttagc tgtcatcttt ttcattatcc 117420
ttattcttct ttcttttcat tttcttgcaa aaattcaatt aactgttgtc tttcatcagg 117480
ggctaatgta ttatacaatc ccagcacctt atgaaacttc ttatatatat ttttagtatg 117540
cttagaatca ttaatttcat cgcccatatc agagcgtgtt gttaaaaggt aattataccc 117600
attctgatac aatttaatcg ttgcttgacc atttatatca gaattaacag aaagtggctc 117660
aaacacgctc tcagactcat ctaagtatac aactacgata ttgtttggtg attcatactt 117720
tacagatact ttagtttgat aagttgggac atcatcttca aaagcatata aaaccaaata 117780
ccatttatag tcataatttt caatattagt aatatcaatc atctgtttaa tacctctagt 117840
atctctttaa cttataagtt actccaacaa ccttaaactt agattcctct ttatttatct 117900
tgtttaaata attacacatt aattgtgcat catagtaggt aataaaatcc ttacaataaa 117960
atgattcaac tactactctc cctaaagcac acttaacaat attgaacatc taaaatcact 118020
accttattga tgggcttgtt taactacata atctaaatca gtatagctaa ttactaattt 118080
acttgtttct gatttaaacc tagttgattt taatttaatg tcgattaaat ttgctcccat 118140
actattttgc tctaacgtaa aattaataag cttgtgatgt agcttccaca ttagttcctt 118200
tagtcccaat tgatgagttg tatcatagat attgttaaca gtagcggtgt tgtttagaat 118260
atctaactca atccctagaa cacaaggaaa cttattaacc agctccaaat aagaaacttt 118320
ataactatca ttcaaataat tgactaaagt ttctaagtta actacagagt caaatgataa 118380
ttctttactg cccattttat taccttcctt acgttgttta gtgaaattat taatttcttt 118440
atctgacctt aaagtcttcc tctcaaatga ataaccagct ttagttaaaa cctcttcaat 118500
atctttgtca gaaaagttag ctactttatt ttcttcatcg ggaacacaat acatgtcttt 118560
agaaaaatta gccatatgat tatttctcct ttaccttagc atctttgcct atttcatctt 118620
ctccaaataa aacttctttt tcatatagtt ctactaaagg agaaagccta ttagataatt 118680
cttgaaggtc atcccattcg gattgttcat atagttcttt tgtgaacaga gaaccactaa 118740
aacatttttc ataaacacta tctgaacatt tcatactaaa taccccctta tctagtaacc 118800
attgtccact ttttttcttt aaccaatttt attgatacta ttcattaata tagtccttta 118860
ttcatatatt tatctagcat aaaatatcct ttcggataat ttcctaccat gcagtttact 118920
ataagctcat aagggactat tcgactattg taaaagtatt taaaatcttt atttactaaa 118980
cgtaaaggac tatctaattt aatataccct tttttaaata tctctttatt actttgatag 119040
tccatatacc taaaatgccg aataatccac caataaatag agtaattatc ttctatatca 119100
atatccttca ttattattat tattatcccc ctgcattact catagcattc cacttatccc 119160
acatttcagt atttttagta atctcatcca attccgggat tctggactca tttatggtat 119220
tactaatact acaatagtgg tacttttcaa ataattctgc ttgaatttta ttaatttctt 119280
cttccatcat ttccgggtcc atagcattag taaactctaa aataattgct tggtgattag 119340
ctttcatatt gtttcctcct ttaatacctt aactatagca catatttaac aaaaagcaat 119400
aaaaaaagag gtaatatccc tctttttatt acatatttag attattaaat ttagacacat 119460
ttccgtaagg cttatgacta accattttag aagttagctt aaccttatct ccaactttag 119520
ataggctgga attaggaaag tcactggtac taattgtgta aatgttgtta ctacctttta 119580
acgaaattaa tacattagag ttacttccat ttgtaataac agccatacgg ttgataactc 119640
cggtagtagt ttctgtcttc acaccattag tgttacctgc accagcatta ccagatacta 119700
aagcatttct aaagctatct aaagcttgtg tagcattgct accactagca ttaattgtct 119760
gattagatgc atctaaatag taatagccac ggaaagcctt agtcttatct aggatggaca 119820
ttacccatac aggtcgtcca ttaatgttat aaataatagg catacttgct ttccattgtt 119880
gggctttata gttctggtta gcattttcta ctgcaccatc actatccata attccctgag 119940
ttttatagaa tgtaagttta ccgtttcgag cattaatcat agaatatcct aaagcactat 120000
ctccaccacc atcacgagta aaatccgtga agtagccaat cgttttatct ttattaaaga 120060
taggtgttac agagctatta gttgaaacca ttacaccgtt attagaaaaa ttccaaaacc 120120
cattcttata cttaccataa gcataattaa tagattcagc tacatccgaa gtaatcccct 120180
catctaccca ttttggcaat ttatcagaag aatacatctt agaatctcct gtatttgcat 120240
tcataacaac cgtgtgtaaa tctttatagt taatccgatg acttagcggc attgacttat 120300
acattgtctc tactaggtaa gggtcgccat tatcgttaat ttctaattgt ggaatactac 120360
tatctgcttt taaccaagta gggtaactct gataaagctt acgagaagct ttcttactaa 120420
accacccact attggcataa gtaatactct tatttacaaa cttaggctga gcatttacat 120480
cagttgcatc aataataaaa tatcccggaa tatgcttagc tttatttgaa gcaaagaatc 120540
catcatattc taatgatgct acatacactg gctttccccg ataatattga gcttcaatat 120600
cacctaaagt ataatactgg ggattaggta catcactcat agatttattc atacgattac 120660
gagcagtagc atacgtaata gaaaccggtg tttcccctcg cttaaaagtg ggggcttcac 120720
tgctattaga cttaatagca gtaatactgc tataaactgg tttaacactc atgtgtgaat 120780
gcaaattacc aacaacgcta gtcaagaaaa caatagctag agttaaccaa agtaatacag 120840
gtagtaattt acttcttttt ttccaactat tacccgcgtt ttttaacaca acaacaccaa 120900
taggaattgt gtaaactaca ttaaggaaca atagacttaa caaatttctc gatggcaacc 120960
caacatagct aaggccataa gcgaatagga aaacaacccc gtataaaata attgaagtaa 121020
gtcctttaat tggctcatta ttaattgaaa gaagaatata aacaatggtg aaaaatagtg 121080
ctaaagctgt tgataaaaac gtaatggtta acataaaaaa tctccttatt taaaaattag 121140
tttgaatttc tggtccatct gtatacatac tatcatctat ttttagtaaa tcaaatataa 121200
atgaataata aggtgtgcta ctaaacatgc cagcaacaaa taacatttta ttagtgtcct 121260
cagaaatata catactcaat cttatcttat aatctgtata atctttctca taaaacttcc 121320
ctctatactc atttttacta aataaatagt cgggcaatac atttgtatta gtatcaaaat 121380
ctctactatc ctctttgtca ggaacatgta tattatatag ctcaccgtca tccaccgcaa 121440
atgaatctac agtataatca cgagtggaac gaacaatggt ctcattatcc ctcaatattc 121500
gagatagtcc taaaatgcac ttagaaacta aatttataca ctcaatagta ttcttcttac 121560
taaattctga aagtctaaag taataggtta ttccagaaga atatatcata tataatattt 121620
ctttataatt attctcatac aacgtacctt ttaaaatatc cttaaagtgt ttacaagctt 121680
taaaatgaat aaaactatta ataatgattc tctttttata cttaattcta taaaaagaaa 121740
gtatcttttc ttctacatca tacacattat taaaagtttt aatgtagttt ttagtagcca 121800
tcaaattctt ttcattatta atgtatattt tatttaaaaa atcattgact atatagttgc 121860
atgttttgta atctgaatac cttaacatat tttattatcc cctaaactag ctctcaggta 121920
aagcaagctc ttttcctagc ttagcaattc ttactagtga atctccatat ggcatggaat 121980
ctaatttgta aagtaattta ttgaaatcgc tatcagtgaa cttatatctt tcttgactta 122040
aatctgagat aggtactgaa ttatctacga aaaagttacc gttatcatct tttctatagg 122100
caactacaca tatattatgc cctgtgtcta agctttgacc aataactaca ttccatttat 122160
tcttaataat attttccttg acttgatacc ctagcaacct tgcttccgcg aatttatcac 122220
cattgtcttt aatccaatta aaaacatcgg gatacatttc atcaagtcca ttcattctct 122280
gcacagagcg gataacgtca tatccttgct gtttgcaatc cttaatatat tctgaaatat 122340
tttcagggat aacaggtagc aatttgtagt tcttggcaaa gtcctcacta tcaatcaatt 122400
ccgggttatt attaggcgat gtcttaatcc aatccccaac cttaactcta acgtatcctg 122460
attcatcttc atctgatgcc aaaaacacac cagaaacttc ctcagggcca tctggggttt 122520
ggataacttt cactactgct tcagataatc taaactgctt agtcatttca ggacttccat 122580
catattttgt aactgttact ggattattct caatagcttt catttgtgat taccccttaa 122640
ttagtcggta ttagtatcct gtaaactctc ctcaaattca attaatcggt ccatatattc 122700
tctacccttt tttaaatctt caatcccatt tttattattc tcgcgaaccg tatacttcat 122760
aatattcatc ttcatagcac cccgaaattc ctcatgagtt agaatatctt gtaaatgcca 122820
taataaatca tgttctccat ttttataatg gtctggttca atagcgttat gcccatagct 122880
atctgactta tcacttgaag gcttaccggt tgtaatatca acattaaatg caagatactc 122940
atcctgtaca cgagcaatta atctatattt tccacttaat cccggctcta aaatacctag 123000
tatatcatcc ttatatataa catgagaatc ctttgtagag gataccctaa ttacatcaat 123060
attaattaaa taattaataa tattaggtag tccaagaaca tgtttaagag tgattttttt 123120
atccttagcc cattccatag aaagtgttgt tagataagta atattagaat ccgcatcacc 123180
atattgcagt acataaggaa ttaaggattc ccctgttctc tcaatatatg cattattaaa 123240
atcagacggc ttcgtatctc taatactcat aattttataa ctcctttaat taatatcttt 123300
taaatcttct aaaattattt ctttatctga tagtgaacta ttatcataag tatacttaat 123360
gtcatctaat acagattcta attcattatc taattttcgc ttatcttttt gttgcttatt 123420
atatttaata ttccaatcct tatccggact atacttacta taataaactt gcattaccat 123480
atctgcccaa gaatcatgac ccaaattgtc tgttaaaggg aaatttcctt ttctttctag 123540
cttagtatct tctaaataaa tacgtgtagc tgttactttt ttaacctcgc atactccaat 123600
acgttcatag ccattataaa cactgtcgta atcaaatttg tataatttgt ctcctacttt 123660
aatatcttta gctttcatcc tcagtaaccc cctataggta attcaataat atccatttta 123720
tttaggttaa gcacttgtct ataaggcaag ctattaaccg ttttccaaaa taatactgtc 123780
ccttgaccta ccatttctga tacatataat atatgtgact taccatattt atcatagtat 123840
tgccattgtt ggtacatact acagaactca ttccccggtt ctaaaggcca acgatattca 123900
atattatcaa atacactacg aatataagat aagggcctat catcttcttg cttaccaaat 123960
tcgctcaatt cagaatcgcc attagggtgt gctagtaagc cttcaattaa tacttgtgga 124020
tttaattcca gcttattaaa aattcgtttg ttgcgaattt gagggtatac aagcatatta 124080
aatattgact tctgcattct taataaatat tcatcactaa aatcatgaat tcgattatca 124140
atttcttctg atgtatgcct atatctagcc aattctttca ccactctcta catgtattat 124200
aaacctaatc agattgcatt tcaagttgat acccatttaa ccctgcatta gcaaccaatt 124260
cctgatattt tcgataacga gcataatcaa atttataagt tcccggtgtg agtgccatcc 124320
agtcgcgcat ctgctctggc cgcctctccg agcacagcat gtcaccaatt gatatatgct 124380
tttgtttaca ctcctcaatc cagtcggcaa catatttagg aatcactggt agctgacggt 124440
atctttcatt aaagtcttta tccttaatta aaatgtgttc ttcggcggta cttgatacaa 124500
tccaatcacc aactgtaagc tttataaacc cgcctgtagt tgcaagcaac aaaccactat 124560
ctgtttcgtc atcaacaccc atattaggta ctacgtagtc tgtgcttaac agtctatcaa 124620
ccatccaatt gctaccatca aattgttcag cttcgaatag ttgagtttta tatactttaa 124680
tcatgctgta cccccaatag tctttttagt cttcgccaac gcggcttgct ttggttaatt 124740
ggcttgcaaa ataacgtatt aatatgctgt gtcccattca aggccagcca aagttgaaat 124800
ttccatttat ccatgctgtt cctccaatag tccttgcctt ttactaatta ccgtccaatt 124860
ccagttagac acctctttat atttaccaca tttatcacac ataatccgaa caaattcttc 124920
atcccaatcc tcgtctatgt ctgatatgtc cactccacag tgagggactt taaattctcc 124980
aaccttaacg aaatgatgtc ggcaaaataa tttcattttc attcccccaa tagttctgag 125040
ttttccttaa tatttccaac aattttgcaa tctctgataa catcacatag gtctaggcaa 125100
agggattcgc caacaacttt aaactttccc tttttaaaaa taaccttgca taccaaatta 125160
ggagataaac taacaaagtc accctcataa atttccttgc cttcgaagtc tttcatacag 125220
cttgataaat ttgctgaacc cttttcgata gagcaccacc actctgtatt tatatattca 125280
tcagtaatct caattaaatt gccaacaatt gcgtcaacat cattattagg gttgccttta 125340
acaagattac cgtaaacaaa gtgcccttta tgcggaatat ctacatagcc atcatactca 125400
atatcatcta aatttttaat gtatgctcta tacatttatt ttgtctcctt attatgttat 125460
aactaatatt taattacttt cagtctatta gttccaagta caacaaaccc ctcacgttga 125520
gcataatcaa ttacacaagt aatttcaacc aataattctc tgcctaaata ctttccatta 125580
tcatactctc gtaagtcaat aaggtcgcct acttgaaagt tcttgtcatt tttacgaatt 125640
tcaaattcct tatcgccccg catttgtagt cccatgtatt ctggcgcaat ttttagctca 125700
tgtaatgtca taatagttac ctccgattat acagcagatt taacattatc taaaacacct 125760
gtaacgttat tatctttctc ttctgaaagt gataaacaat tattaattaa ttgtgattcc 125820
ttttctgaat gatacttagc gggattctta atggttgtta ctcgaatatc tttaatattc 125880
atattttccc aatcttttgt aactgcccca ccaatatttt tagcgtacgc aatattacgt 125940
ttgatacacc aagcatataa taatttttgt tgttcatcag ttaaattatt atcgaaagtt 126000
ccataagctt gtaccaatac attatctggt gaaacttcca aagtaaccca cgaatttcga 126060
ggtgccattc gtgaacgtaa aaatagaata ttagtttttc cttcgctaac agaatttaca 126120
taagaaccga cacaattact attattattt ccttcttcaa caatctcttt actacttaca 126180
gcatcaatta agaaataatc ccccaataga gcatcaaact tttcatgatt atgttcccaa 126240
taattaacta ctttgttact agtatctata ttgtctaaaa cagataagtt ctgcataaca 126300
acatcatgtg ttgtctttaa ataacgagga taacggggaa ccttttcata atctttagtc 126360
atttgatagt agtctctcaa aatttgtaaa gattctcgaa tagttggaag tccttgctgg 126420
tggtaacaac tagcatatag atagcggaat aaattcttat acgtaacccc cggcgtctcc 126480
aaaacctctc ctagataaga actccattta atgttactct ggtacccact aattaattca 126540
ccgatgtttt cattaatcca gcggtctgca tcatgatacc ctcgttcctt atcaacctga 126600
tgtacggaat catcaaagct ttcaacaagc ttatttaatt ctttaatatt catactatca 126660
agacttaaaa tatcatccaa aacgtttcca cttgcttttt taacaatata ttcatagatg 126720
gttttattag ctggtttgat ggcttctcga atactatttc cgtaggtttc agttctatct 126780
acaatattct taacagcact ggcactgata ttattcccac gataattata tagttcttta 126840
aaaatcttct caaaagtagg atgtttagcg ataccacgca taatcccacg accgatattt 126900
ctatcttcca ttgagtatgc accatatgct agtcccatgt tgtaaaacat cttaatatta 126960
atgtcatcaa aatatcctga aaaagcttta ccataattaa acaatttatt taaagttgtt 127020
gcatttgctt ttaaacgttt tccagaaact ccttctacaa agaactctcg attgatgagg 127080
tcaataacaa acccatagta gatattactt gtctttccat cccaactctt ttgcttatag 127140
cgtgcaaaac ctgaaaatag tccacggtcc ttagaccaaa acttcaaact atatccatct 127200
gattcaccga ggaagttatc aatagctctt tttttatcct taatagttac tctattcata 127260
tataaatcac tactttctag ttgatatact catcttagca tacaggatag aaataatcaa 127320
tgtaaaaaat aaaaaaaaag tccctataac cggacttttt tcatactttt ttatgctgta 127380
attacgtgtg cagacatatc tcgtgtatca atatatagat ataatactcg tttattcgaa 127440
gagttaaatt gcgtaagctg gtctaaatca acagcataga taaaactacc tacagggttt 127500
agtttaagct cataataatc aatatcagtt tttaaagtta atttagtata ttccggatta 127560
gcagttaccg catctacata gaataatcca tctaatgtaa tctttttgtc taaactaaat 127620
ttaatagggg cctgttttga aattttatat ttaaagtcta attcctttaa atactttact 127680
agtttattag acatgttatt atccccaata aggtatgata gccgttgaaa aatttcgtca 127740
ctttcttctt tactgaaact attttcaggg ttttctgaat cattaggttc ttcaaaaaac 127800
tcccggaatt tctttcgcaa atcatcgtct ttaatattat gtttatctag gatatttgta 127860
atagctagat atacatcttc ttgtacatca tcatctaaat agataacaaa atttgcattt 127920
tttgttacct gaatttcatt gctgttaatg tacacgtctt catcaagaag tttatctcta 127980
atttcttgaa aaacatctgg gaataaatca tttaattcta aaatttcatt attcatattt 128040
tttctcctaa gttttattgg ttaaacacaa caacgccgac attagaatga ttatgactat 128100
caacctcaat atcttgataa attgacaatt tcatatttag cttcttggct aactccccta 128160
agaagttctt atcttgatta agcagtttgc ttactgctag ataattttcc aagtccttat 128220
tgcaagctaa ccaattactt cctaaatact tatctcgtaa tttataagct acggattctg 128280
aaacattttc attatccatg agtaagaatt ttaattcctt gttacctagc aattgattat 128340
gatagtttaa taatgaaaat ttgctcaact tatctgagat tgtcattgtt attacctgct 128400
ttcttagtat atttaaatac tagcatacaa ataatcatat gtaaataaaa aattcccaat 128460
taagggaatt taatgaaata tattaaacat ccgtatcagt attgaagcta atctttttat 128520
cagagggtgt gtctgaacca ctgtcagatt tacccttatc ggaatatcca gaatctgact 128580
tagatacatc agattcagaa cttgtagtct ctgctacatc cttagttaaa tcaccatcta 128640
ctgttggtgt ctctgcaaac aattcatcca aatagtcaac aggaacatca ctaatattaa 128700
ggttgatagc attaatagct tcctcaacag taccaaaagt tactacagac tttgtatata 128760
gcttgtttga taagtcttct aacttcataa attctgggaa taccaaattt ccctttgcat 128820
aattaaataa attaaatact tcatctgagg tatccttatt catggcaagg acacgagtaa 128880
ttcctcggaa aacttgccct tttcctgttg ggtcaacccc attaattact aaaatatctc 128940
ctgcatcaaa tgttacttta ctatttgctg tcattgaaaa ttacctccaa tttaatatac 129000
ctatattata ctacttaatc taataagtta caaggtccct atcagggaat atatctttat 129060
ttggattctc tgtagtcgtg gttgttgttg tagttgtggt cgtctgttct ctaattaaac 129120
caatagtaat tacaacatca ctgccatcta ttactttata actactatat ttatctccaa 129180
ttaatcttaa taaagacctt aaacttaggc attgtgtcac aattgactct cctgtcgcaa 129240
tatccactac tgcgtatcct atatccgcag gggttgctat attttcatcc tcatacgttc 129300
ccccagataa atttccatag ggattcttat caaaagtatt ttgattatcc tctgtggttg 129360
tagctacagt tgtggtacta gttgtagtag ttgttgtggt gctatcttct gtgtcatcgc 129420
ctttaggaga agttgataca atccgagcaa gataaattaa ttcaccagat gaactataag 129480
ctaatatata atcacctaca cctatattat ccgtcttttc ataaaaatta tctaacatat 129540
tatttattgt tgccattatt ttcaccacct tcctgtttat taatctaaaa aagagaagga 129600
atttccttct ctttcgtcta gctgtagata actacaaacg taccatcata ttgaaaaact 129660
aaaggctttt cttctgtggg tgtaaactta gcataagttg caatcttact attaacctca 129720
gccgggctac ccccagaaat aaagaatcca ccgtgtgtta agacttcttc tctaatccca 129780
tccagcaata cattagatgt aatccctaaa gttttcttta ctttttctaa atccatatat 129840
ttaaaacttt catctgaaaa cataaataaa tcaccacctt taaaatgctt caataatgct 129900
acgcatacta gtaatgtttc ccatatctaa taattttaat cgagtagcta aagtatatac 129960
aatagctaga ctaacaaaga ccaaagaatc taaaatatca tcagataatt ctggatactt 130020
gctgaaactg ttaaggtaaa ttgcaatttg tgaagtaaat tccgaataca gggtggatgt 130080
ctttgcatca attcctacaa acattcctag catttctttt gaaattaaac tgcctttagg 130140
gtctctacca ccactggttt cttttttaat tttaatcata ttgtaggaca caattgcatc 130200
ataagcgtaa gccaaagatt ctaatactac ctctgctgtt tcttcatttt ctgaaatttc 130260
ttttaattta tttaaactag gttcatacga atctgaaagc atagacacgt atccagacaa 130320
ctcgttttta attaaatcac tcattttgtc atttaaacaa agaattgtaa aataattaat 130380
aagctcatta gcgtcatctc gcaaagtatt atcaatatct tctaactcca acatactgat 130440
tctcatatca cgagaaacta ataagtaaat actaggtaaa atgtctgagt aagaataagc 130500
taacagggaa tctaaatttg taaacttcat agaataaaat ttatcactta aactaatatc 130560
ttttgaactg attgtgagcc acccctttat tatcctttaa cctcaaattg ctcttccttg 130620
taggctctag cacgctcttt agcttgttta tacagaatag gataagtcct atcttgcata 130680
tctataatta aagcagtttt cttttttgca gatacacgaa gcattcgacc aacccgttga 130740
agaagttgtc tgacactttt accagcagaa gcataaatca taaactttaa gtcaggtaca 130800
tctaacccct catcaattag ttgagtacca attaaaacct gagtttctcc tgatttaact 130860
cgcttaataa ttgcttctct atcctcactt gtatctgagg atgtcataaa ttctgtagta 130920
atatctaact tatctaaatg gtctttaata atctcgccat gttcaatact attaacaaca 130980
attatcatgg ctccttcacc agagtctaat aatttcttgg ctgttagagc taacaagtta 131040
ttacgatagc cattttcgat aacaccgtac ctataagcta tttgatagtc cattaaggct 131100
gtctgtcgct tgttagcatc cttaggcatc ttactatcaa taatctcagc taagttatta 131160
ggcttcgtta caggtagtaa tataatggtt ggcttagcag agtaaccttt attaattaag 131220
tcaatatttt tagtaacaat catttcatta ccaaaaatcc cttggaaata tccgtactta 131280
acttcttttc ctgttccatt aggaactgta cctgttaaac caatcttcat tctagcatgg 131340
gttagattac ttacaacttt ttgatacata ttagaagccg cgtggtgggc ttcatcaata 131400
attaaaatct taacaccgtc taaaatattc tttgcttcct catatttatc aaaagacttt 131460
ttattctttt ttcttaataa tttattgtaa gcatctattt cccattgcat agccttagct 131520
attttcttat ctgaaatatt tgatgaaagc atgtctctta aatcactaga gatatttcta 131580
tcatatgaag tcttaggttt attattaagt aagtatgtct taatcctaat acgctgattt 131640
tcacctgtaa caaacttagg tgcaacctct aaagcaaaat gctttaatgt cttatctttt 131700
tcattcgtta gcttaacacc atcactaggg tcttttaagg ccgaattaag cgttccaacc 131760
atagccacgg taacttgttc caattccttc ttaccatcgc cccacaagcc tacaggcatg 131820
tttaaacgct ctgatattct ttttctggat tgattagcaa taactttatt attacacata 131880
aaaaatactt tttcatctga tgctaaagcg tgtaaggatt ctttaataat tgctgatgct 131940
atttcagttt taccactatt agtcgcacca ttaacaaccc cgacctgatg cttgaacgca 132000
aaattaacgg agtcaacctg atgctttcgt agggagatag tccccagctt actatcgggt 132060
aatgtataag gctctggtaa agtttcgtgt tcagggacga ctttatcacc ccttaaatca 132120
ctaatagtca catttagctc tgggtgccta gacttttctt ccttaattaa tttttcaacc 132180
ttaaacatta atccagaaga aaactcttgg gttttagtat tatacattgc gactcttccg 132240
tcccaagcat gtaatctata agctcttgcg ttaaatctat ctgggtcaaa aggacttaga 132300
gtttcataga tttttttatt catatactca gcaaattcta tagattcatt attatattct 132360
atttttcctt taacattatc taaatcaatt ttcaagaata ctttcctcct cccaaatttt 132420
agtattgccc tgagaaatga caacttcata tttccctaat tctaatcctg ctacttgcgg 132480
gtcttcatca taaatgattc cctcactaat tttataggca atatctaaag ataaactttt 132540
agaataagga ataatcttat taccttgtac aatatctatg gagtaaatac cttccatcag 132600
caatacaccg cctttttatt ttataacgcc ttatgttaat tataccacat ttaaagcata 132660
gttaacatat tcatttaagt aaaaaaatag agattactag ctctttacat ctagtaacct 132720
ctatttaatg cctgatggaa gaatatcagc aatactctaa tagggaatcg aaccctaatc 132780
aaaagtttag gaaactattg tgctatccat tacaccatta gagtaatatt atatatttat 132840
atatatcatt taaaaaatat tataataact gttgattata acttaattta gtatgatata 132900
gaacctttta acatattgga ttaccccctt acttgtacat aataacattt ataataagtt 132960
tagtcaataa tttttaaaat aaaaaaaagg atagttcccc atccttctat gtggggttta 133020
tccttacgag ttccctcgct aattccgcta ctatctataa tatagtaacg tactcagggt 133080
ttttaccatg accctctcaa ccatctaatg ttagcattag attttgggat attccatatt 133140
aggaatcgcc ttttgcttta ttccccacat atatactgac caaggaaaat tgctaattaa 133200
tgtcagttaa caaggaatca tacatcctcg ccttatttac ctaattatcc cgaagttact 133260
taggccattc ctataattta tgtatgctac taatagggga taatatttaa gaataataaa 133320
atgtataaac tctcgacaac ataatatcat ttacttaatt ccatcctact agtagacttt 133380
actatctcaa ccgaggttag accagatagc ttggtttctc tactaaatac tcatcaccat 133440
agggtgatta acatattttt cgactgcgcg cttctcggaa ctcataaaaa ttcgtaatgt 133500
ttaaagagca tagcagtgct cttaaaatac tccctataag acatgataac aataatacta 133560
attacttgat aaacatagct gtaaataatg ataggctaag ggggtcagat aaatctaaag 133620
ggttatacaa actatctttt ggggtgtctt cttttaattc actatcgtgt gaattaaaag 133680
agtgattggg taagtcttcc ttttcattac tattttgtgt ttcactcatt taagtcacca 133740
cctactattt actagtatta aagattgccc agccgtggag tcgaaccatc gtgttcctag 133800
agtcgcgaac ttctaggctt atccgaatct gggcataata tagtgtaggc cacatcataa 133860
tcctacactt gatgagtttt cggtcatcat caagactaac gctaggttat aatgccaccc 133920
gcggggcaat gagcttttct ttcaatcaat attattaatt aatctagcta ctaagaggta 133980
taactctaac cctatcgggg ccaatgctta tcaccgatgt agcccgacaa taaacattat 134040
aggctaaaaa tgttatcaac atataattta atatattata tgttgataac tacggaaagt 134100
acaggacttg aacctgcaat acccagaggg tacaacgagt tagcaacccg cttcaatacc 134160
aattatgatt aactttccaa attttatact taatacttgg atgacgggag ttgaacccgc 134220
aacagcttga atcacaatca agtgtgcaac cagtagcacc tcatccaaat gccaaaggta 134280
tgattcgaac atactcaccc ttttgagaac ggttttacag accgctgtgg ctcaccatct 134340
ccaccgcttt ggcatattta attatatatt gtaactaacg gacaagacag gactcgaacc 134400
tgcaagtcgc tcacacggcc aactgttttc aggacagcct gctaaccaat tcgcttcttg 134460
cccaaaatat atacttgata gggattcgaa ccctacactt catctagccc taagcaccta 134520
cttctatagt agtgtcgaac tacttcgcag ttagatgtca gattatgata tttctatctt 134580
tagtgtctac acccttccac cacaagcata tgtagttaag catcaactat aggtccgcat 134640
aaaacaggaa aggaaacatt atctccttta atttgttttc ctactacttg atagtctatt 134700
ttactaccgg agacattttc aacccgaatt gcatgaatgt ctgaaatctc tccaaaatcc 134760
aatgataagt tatttaaagt tgcagttacg tgactgttta cttttgtata gcccttatca 134820
aggtcacgct catcagaaat gttataaata ccttgttgtc cgtactccct cgttacatct 134880
aaactatgag ctatgccaaa tataactccc atatggttaa taacaaatat tgtgttacca 134940
tgacttactg acataataac ctcctaatag tttaagatag tcccggtggt aatcgaaccc 135000
aaaaacattt catctatctc taatccctta cttccattcc ctactatgtg taggtaaatt 135060
atacttttta caccattttc taagtgaatt atctgtcatg ttaaagcctt ttgctgattc 135120
agtaaagtta ccattagtct taattaagga actagtaatt tcttcttttg ttaaaggctt 135180
cttattcttg tatagggaag gacctttttc ctttgcaatc aactttgtag cacatgcttt 135240
acatcttgtg gctttatatg ttattaattt cccacaatct acacaactat gggttcctaa 135300
tgtgttgtga ctgtctacat agttacccat attaaaaata gccatatcaa tagagttttc 135360
tttcgcggta caccattcta aattagatac gttgttattt tctctattat ggtctatatg 135420
attaacttgt ggcaagttat atttattcgg tatgaaagca tttgcaacga gtctatgaac 135480
taatttacca atagatttat tatctctatt tagacctacg ttaacataac catttctatc 135540
ttttgtagta gaaagttttc taccctttat atgcttactc ataccattag aagcggttat 135600
tactctatct aatgaccgga cattaccttt agaagaaact tgataatatc cctcgtatcc 135660
agttatatct ctccactctt ccaaagtaat cgccttctat catcagtttt tattatggtc 135720
ctagaatgtg ctgcccattc gtctcacact tatagggtgt gccctctact gttgagtata 135780
taggaccaat aactgccctg actggactcg gaccagtgac cttcgcatta acagtgcgcc 135840
gttctaccaa ctgaactaca gagcaatgat agcataccct aaaaggacat taatgaaaaa 135900
cagtatgctg acgttttacc ttattgtatt tatgatacaa gcgaataacg agaatcgaac 135960
tcgtatctac agcttggaag gctgtggttt taccactaaa ctatattcgc ataatggggg 136020
atattagtca tcggtcaccg accttgccac caaatataat agttagtggt tacctatcgt 136080
agcaagcctt gatagatatg ctaataccaa aaacgcacta ttacgattat cactgtttaa 136140
gaacatgaat aacataaata atataaataa taag 136174
Claims (5)
- 자연으로부터 분리된 락토바실러스 브레비스 균을 특이적으로 사멸시킬 수 있는 능력을 갖는 서열번호 1로 표시되는 유전체를 갖는 것을 특징으로 하는 시포비리대 박테리오파지 Lac-BRP-1 (수탁번호 KCTC 12659BP).
- 제1항의 박테리오파지 Lac-BRP-1을 유효성분으로 포함하는 락토바실러스 브레비스 균의 오염 방지 및 처치용 조성물.
- 제2항에 있어서, 상기 조성물이 바이오에탄올 생산 공정에서 락토바실러스 브레비스 균의 오염 방지 또는 처치 용도로 사용되는 것을 특징으로 하는 락토바실러스 브레비스 균의 오염 방지 및 처치용 조성물.
- 제2항 또는 제3항에 의한 박테리오파지 Lac-BRP-1을 유효성분으로 포함하는 조성물을 투여하는 단계를 포함하는, 락토바실러스 브레비스 균에 의한 오염을 방지 또는 처치하는 방법.
- 제4항에 있어서, 상기 조성물이 바이오에탄올 생산 공정에서 락토바실러스 브레비스 균의 오염 방지 또는 처치 용도로 투여되는 것을 특징으로 하는 락토바실러스 브레비스 균에 의한 오염을 방지 또는 처치하는 방법.
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KR1020150013453A KR101679548B1 (ko) | 2015-01-28 | 2015-01-28 | 신규한 락토바실러스 브레비스 박테리오파지 Lac-BRP-1 및 이의 락토바실러스 브레비스 균 증식 억제 용도 |
PCT/KR2016/000029 WO2016122127A1 (ko) | 2015-01-28 | 2016-01-05 | 신규한 락토바실러스 브레비스 박테리오파지 Lac-BRP-1 및 이의 락토바실러스 브레비스 균 증식 억제 용도 |
US15/543,634 US10227570B2 (en) | 2015-01-28 | 2016-01-05 | Lactobacillus brevis bacteriophage Lac-BRP-1 and use thereof for inhibiting Lactobacillus brevis proliferation |
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KR101649851B1 (ko) * | 2014-12-30 | 2016-08-30 | 주식회사 인트론바이오테크놀로지 | 신규한 시가독소생산 F18형 대장균 박테리오파지 Esc-COP-1 및 이의 시가독소생산 F18형 대장균 증식 억제 용도 |
KR101761581B1 (ko) | 2014-12-30 | 2017-07-26 | 주식회사 인트론바이오테크놀로지 | 신규한 장침입성 대장균 박테리오파지 Esc-COP-4 및 이의 장침입성 대장균 증식 억제 용도 |
KR101761578B1 (ko) * | 2014-12-30 | 2017-07-26 | 주식회사 인트론바이오테크놀로지 | 신규한 장병원성 대장균 박테리오파지 Esc-CHP-2 및 이의 장병원성 대장균 증식 억제 용도 |
KR101679548B1 (ko) | 2015-01-28 | 2016-12-06 | 주식회사 인트론바이오테크놀로지 | 신규한 락토바실러스 브레비스 박테리오파지 Lac-BRP-1 및 이의 락토바실러스 브레비스 균 증식 억제 용도 |
KR101679549B1 (ko) | 2015-01-29 | 2016-12-06 | 주식회사 인트론바이오테크놀로지 | 신규한 락토바실러스 플랜타룸 박테리오파지 Lac-PLP-1 및 이의 락토바실러스 플랜타룸 균 증식 억제 용도 |
US11058131B2 (en) | 2015-04-16 | 2021-07-13 | Kennesaw State University Research And Service Foundation, Inc. | Escherichia coli O157:H7 bacteriophage Φ241 |
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US20170369852A1 (en) | 2017-12-28 |
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