KR20160069610A - Method for manufacturing extracts of red ginseng and natural plant having effects for stopping hair from falling out, promoting hair growth, preventing skin aging, promoting skin regeneration, anti-inflammatory and anti-bacterial, and composition comprising the extracts - Google Patents
Method for manufacturing extracts of red ginseng and natural plant having effects for stopping hair from falling out, promoting hair growth, preventing skin aging, promoting skin regeneration, anti-inflammatory and anti-bacterial, and composition comprising the extracts Download PDFInfo
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Abstract
Description
The present invention relates to a process for preparing red ginseng and natural plant extracts and a composition containing the same, and more particularly to a process for producing red ginseng and natural plant extracts from red ginseng and natural plants, which are effective for preventing hair loss, promoting hair growth, preventing skin aging, A method for preparing red ginseng and natural plant extracts capable of producing an extract, and a composition containing the extract and a natural mineral salt.
The human hair is about 100,000 to 150,000, and is known to be formed in "hair follicles". And hair follicles have nipples, where small blood vessels are distributed to supply nutrients needed for hair growth. Each hair has a different cycle and grows through anagen, catagen, and telogen, and then falls off. This cycle repeats over 3 to 6 years, with an average of 50 to 100 hairs dropping normally on a daily basis.
In general, alopecia refers to an abnormal increase in the number of hair that has fallen due to a shortening of the growth rate of hair during this cycle and an increase in the number of retrogressive or maintenance hair.
The causes of hair loss include male hypothyroidism, excess sebaceous glands, poor blood circulation, peroxidation, hypofunction of the scalp, genetic factors, aging, and stress. Generally, it has been reported that testosterone, which is a male hormone, is activated by dehydrotestoserone (DHT) by an enzyme, and DHT binds to a specific receptor and induces a protein that causes hair loss, resulting in hair loss have. In addition, this mechanism causes excessive production of sebum, and acne and seborrheic dermatitis are caused, resulting in hair loss accompanied by inflammation in the scalp.
In addition, human skin becomes considerably more varied both quantitatively and qualitatively with age. Besides this natural aging, it is stimulated by various external environments. For example, a series of changes occur by molecular biologic changes or external physical and chemical factors. In skin aging, the amount of collagen protein secreted by fibroblasts is reduced and wrinkles occur on the skin.
Collagen is also destroyed by ultraviolet exposure, which is an external cause of skin aging, and changes by ultraviolet rays are known to be proportional to the accumulation of time during exposure to ultraviolet light. Ultraviolet light accumulates elastic fibrous material in the dermal layer of the skin and denatures the collagen fibers, causing wrinkles on the skin and reducing elasticity.
In recent years, there have been various studies for prevention of hair loss, promotion of hair growth and prevention of skin aging, and in the case of domestic, mainly using a herbal medicine or a natural plant extract is the mainstream.
Korean Patent Laid-Open Publication No. 10-2000-0031349, for example, discloses a hair growth inhibitor composition using herbal medicine extracts such as ginseng, astragalus, Hanhyuncho, Bogolji, Angelica gigas, The present invention relates to a composition for promoting hair growth and a method for producing the same, which comprises using as an essential ingredient ogga, ginseng and apple juice. Korean Patent No. 10-0982414 discloses a hair growth inhibitor composition comprising a fungus extract, a fungus extract, a flaxseed oil and an alpha-tocopherol. In Korean Patent Laid-Open No. 10-2012-0038585, There is proposed a herbal extract for preventing hair loss, which is prepared by mixing Hwangjeong, Hwanggi, Baekji, Japanese chrysanthemum, licorice, and ginger. Korean Patent No. 10-1259589 also discloses a method for producing fermented rice extract for inhibiting skin aging and a cosmetic composition for inhibiting skin aging containing the extract.
However, the extracts and compositions according to the prior art have insignificant effects such as prevention of hair loss, promotion of hair growth and prevention of aging of the skin, or have little sustainable effect.
Accordingly, the present invention relates to a method for preparing red ginseng and natural plant extracts having excellent hair loss prevention and hair growth promoting effect, skin aging prevention and regeneration effect, anti-inflammation and antibacterial effect, and extracts using the red ginseng and specific natural plants The present invention provides a composition comprising
According to an aspect of the present invention,
Obtaining a mixed extract-1 obtained by extracting hot water of red ginseng, giardium, seokjangpo, wussle, raw ginseng, ginseng, yugunpyu and raw persimmon;
Obtaining a mixed extract-2 obtained by extracting licorice and chrysanthemum with hot water;
Obtaining a mixed extract-3 obtained by mixing the mixed extract-1 and the mixed extract-2;
A first purification step of passing the mixed extract-3 through a filtration apparatus equipped with an activated carbon filter to adsorb and remove pesticide and heavy metal components;
A second purification step of separating the mixed extract-3 from the inert carbohydrate and the colloidal suspension using a centrifuge;
A third purification step of passing the mixed extract-3 through a filtration device equipped with a bacteria elimination membrane to remove bacterial microorganisms; And
The purified mixed extract-3 is subjected to a post-treatment step in which at least one selected from the group consisting of concentration and drying is subjected to a process for preparing red ginseng and natural plant extract.
Further, according to the present invention,
Obtaining a mixed extract-1 obtained by hot water extraction of red ginseng and yugun peel;
Obtaining a mixed extract-2 obtained by extracting licorice and chrysanthemum with hot water;
Obtaining a mixed extract-3 obtained by mixing the mixed extract-1 and the mixed extract-2;
A first purification step of passing the mixed extract-3 through a filtration apparatus equipped with an activated carbon filter to adsorb and remove pesticide and heavy metal components;
A second purification step of separating the mixed extract-3 from the inert carbohydrate and the colloidal suspension using a centrifuge;
A third purification step of passing the mixed extract-3 through a filtration device equipped with a bacteria elimination membrane to remove bacterial microorganisms; And
The purified mixed extract-3 is subjected to a post-treatment step in which at least one selected from the group consisting of concentration and drying is subjected to a process for preparing red ginseng and natural plant extract.
In addition, the present invention provides a composition comprising the extract prepared as described above. In addition, the composition according to the present invention may further comprise a natural mineral salt.
According to the present invention, it contains red ginseng extract and specific natural plant extract, and has superior hair loss prevention and hair growth promoting effect, skin aging prevention and regeneration effect, anti-inflammation and antibacterial effect.
1 is a photograph showing hair growth results of an extract according to an embodiment of the present invention.
FIG. 2 to FIG. 4 are photographs showing the result of the fixation of the composition according to the embodiment of the present invention.
5 to 8 are graphs showing the amount of hydrogen peroxide generated in the mitochondria after application of the composition according to an embodiment of the present invention.
9 is a photograph showing a result of a sterilization test of a composition according to an embodiment of the present invention.
10 to 12 are graphs showing the results of an anti-inflammatory effect test of the composition according to an embodiment of the present invention.
Hereinafter, the present invention will be described in detail.
In the present invention, 'and / or' are used to mean at least one of the components listed before and after. Also, in the present invention, terms such as " first, "" second, "and" third, " and the like are used to distinguish one element from another, It is not.
In the present invention, red ginseng (Korean red ginseng) extract and nine specified natural plant extracts (herbal medicine) are used. Further, according to a preferred embodiment, natural mineral salts are further used. First, the red ginseng (Korean red ginseng), the nine natural plants (herbal medicine) and natural mineral salts used in the present invention are as follows.
In ancient times, red ginseng has been used as a first-aid medicine for prolonging the life of ginseng medicine (强壯 药) or dying patient, and has been desired for rejuvenation or rejuvenation. Especially, Korea red ginseng is like this. In the 20th century, due to the development of science and technology, the chemical pure separation of Korean red ginseng, which had accumulated in the mysterious for thousands of years, was promoted in earnest and the chemical structure, efficacy, and effects of saponin, Since the late 20th century, studies on various components such as polysaccharide, protein and pectin have been proceeding. Therefore, Korean red ginseng promotes the secretion of growth hormone involved in hair follicle cell and skin cell growth, And blood vessels to remove wastes and smooth blood flow to the tissues and cells to nourish the supply of antioxidant effect of anti-aging skin, anti-inflammatory, anti-bacterial effect and lipid removal effect, Pharmacological efficacy in cosmetics and pharmaceuticals Books are worth reporting very high.
The gill bacillus can be divided into g + (Staphylococcus, Streptococcus, Streptococcus, Lactobacillus, Diphtheria, Tetanus, Anthrax and Actinomycetes), g- (Salmonella, Dysentery, Typhoid, Cholera, It has antimicrobial effect because it has antioxidant ability to inhibit the growth of spots, acne and freckles, whitens the face and prevents the skin from keratinization.
Seok Changpo is effective for mental concentration and mental stress, and it is helpful for healing of insomnia, and it is reported to be effective for skin itching, eczema, bacterial dermatosis and rash and inflammation caused by chemicals (such as vaccine).
It is effective for boils, pressure sores, inflammation and purulent skin diseases. It contains insecticidal hormones, potassium, and mucus, which are effective for arthralgia, diabetes, diabetes, diarrhea and bone marrow replenishment. It is said to be whitening, and forgery and healing of back and back pain.
Origin and Sources Saponin is weakly toxic, enhances secretion of mucosal glands, and enhances permeability of tissue epithelium. It is effective for skin diseases such as wounds (milk sickness), porridge, and plumage. It facilitates penetration of medicinal ingredients in the skin and facilitates the release of wastes, fat, and pumice in cell tissues. It can be used as a soothing, antimicrobial, genetic, coercive, haemolytic, uterine stimulating, anticancer action, plant stability, forgetfulness, astonishment, chest stretch, phlegm cough, hypnotic action, , Pneumonia, and laryngitis.
Gosam has excellent antimicrobial action to prevent inflammation, alleviate itching symptoms caused by atopy, and contains alkaloids and Polarbonide. It has a strong antibacterial and antifungal action against skin eradication. It is excellent for the removal of decaying secretion, trichomoniasis, eczema, neurotic dermatitis, endometritis, skin disease, leprosy, skin whitening effect, jaundice, dullness, hemorrhoids, In addition, it has been reported that the
It is effective for sinusitis and rhinitis because it contains flavonoids, saponins, tannins, and mucus components. When applied to the skin, it treats various skin diseases, and beautiful and smooth skin. There is a strange effect. It is known that Yukunpi has excellent anti-inflammatory and antimicrobial effects, and has excellent healing effects on atopic dermatitis and bacterial skin diseases by sucking pus and sowing new skin when it is applied to purulent dermatitis such as wounds (milky wounds), boils and swellings .
It is effective against inflammation, fever, swelling and analgesic effect when it is applied to a fracture or bruise, and it has excellent effect on inflammation, Hair dry, etc.) have been reported to improve skin rash.
Licorice has a sweetness of 4 to 50 times that of candy and has a strong surfactant effect. It is known to release drug poisoning and has a strong anti-inflammatory effect. Glybridin has the effect of inhibiting pigmentation and erythema induced by the sun's ultraviolet rays, and has anti-inflammatory action. It inhibits the production of peroxides and the activity of oxidizing enzymes, thereby preventing skin aging and producing skin melamine and inflammation . ≪ / RTI > In addition, triterpenoids such as glycyrrhizin, polyphenols and polysaccharides have been reported to have various pharmacological actions such as strong anti-inflammatory, antiviral and anti-ulcer effects.
Chrysanthemum is mainly composed of berberine, berberine is a drug used to treat diseases caused by bacterial infection and belongs to alkaloid substance. In addition, it has antibacterial effect and it is effective as anti-bacterial action against Staphylococcus aureus. It is effective as anti-inflammatory and antipyretic drugs. It is also applied to pneumonia, jaundice, uterine inflammation and urethritis. It is effective for external acute purulent skin diseases, oralitis, conjunctivitis, It has been reported that there is a large inhibitory effect on Disease, Mycobacterium tuberculosis, Escherichia coli, Pseudomonas aeruginosa, and meningococcal bacillus, respiration, excitement, sedation and muscle relaxation, vasodilation and local anesthetic action.
Natural minerals are salts that contain natural minerals because they are trapped in seawater, and when natural purification, aging, and high concentration of the mineral salts (toxins of salt) are completely eliminated and 99.5% of natural sea mineral salts are produced. In Donguibogam, these mineral salts are said to be warm and poisonous in nature, and that they control the vomiting of Chinese herbal medicine, moxibustion, kwaklan, and under the thong,
In addition, the natural mineral salts are all life-enhancing metabolites that produce all metabolic energy, growth, disease healing, and enzymatic action. They function as acid and base, control the balance of human body moisture, remove vital wastes, , Food metabolism enzymatic action, hormone production and function, cell metabolism and so on, and has been found to have a variety of effects.
Therefore, in the present invention, various efficacies and effects of the extracts of the active ingredients of the red ginseng (korean red ginseng), gyeolbipi, seokchangpo, wusu, rawji, gosam, And / or the skin is also applied as a material to the field of manufacturing pharmaceutical products for the manufacture of various types of cosmetics having hair loss prevention, hair growth promotion, skin aging prevention, skin metabolism promotion, dermal waste removal, anti-inflammation, antibacterial effect and / / Or a composition for skin application. The present invention relates to a method for producing a second extract containing red ginseng (Korean red ginseng) extract and nine specified natural plant extracts, red ginseng (Korean red ginseng) extract and three specified natural plant extracts , And a composition comprising the first extract and / or the second extract.
Preparation of first extract
According to a first aspect of the present invention, there is provided a method for preparing a mixed extract-1 comprising hot water extract of red ginseng (Korean red ginseng), Gyobolpyu, Seokchangpo, Wusel, raw paper, Obtaining a mixed extract-2 obtained by extracting licorice and chrysanthemum with hot water; Obtaining a mixed extract-3 obtained by mixing the mixed extract-1 and the mixed extract-2; A first purification step of passing the mixed extract-3 through a filtration apparatus equipped with an activated carbon filter to adsorb and remove pesticide and heavy metal components; A second purification step of separating the mixed extract-3 from the inert carbohydrate and the colloidal suspension using a centrifuge; A third purification step of passing the mixed extract-3 through a filtration device equipped with a bacteria elimination membrane to remove bacterial microorganisms; And a post-treatment step of proceeding at least one selected from the group consisting of concentration and drying of the purified mixed extract-3. (Preparation of first extract)
According to a more specific embodiment, red ginseng (Goryeo red ginseng), Gyobolpyu, Seokchangpo, Wusse, raw paper, ginseng, yugiwipi and raw persimmon are mixed extract-1 and licorice and chrysanthemum are mixed extract- - 2 was cooled to room temperature, and mixed extract - 1 and mixed extract - 2 were mixed and mixed with Korean red ginseng and 9 kinds of natural plants Extract-3 is prepared.
In order to remove the pesticide residues and heavy metal components remaining in the mixed extract-3, the mixed extract-3 was passed through a filtration apparatus equipped with an activated carbon filter to adsorb and remove the pesticide and heavy metal components, The inert carbohydrate and the colloidal suspensions are removed using an ultrafast centrifuge at a revolutions per minute of 10,000 rpm or more (for example, 10,000 to 15,000 rpm) to remove the existing inert carbohydrate and the colloidal suspension, 3 was fed to a TFF-type micro-filtration system equipped with a membrane for sterilization with a size of 0.45 mu m to remove the bacterial microorganisms. To obtain Korean red ginseng and 9 kinds of natural plant mixed extract-3 from which bacterial microorganisms have been removed.
Finally, purified Korean red ginseng and 9 kinds of natural plant mixture extract-3 are concentrated by using a pressure-reducing concentrator according to the purpose of use to obtain a concentrate of mixed extract-3 of a certain concentration or by using a freeze-drying or spray-drying apparatus To obtain ginseng Korean red ginseng and 9 kinds of mixed extract powder. (Preparation of first extract)
The mixed extract-1 may be prepared by mixing 1: 0.5 ~ 2: 0.5 ~ 2: 0.5 ~ 2: 0.5 ~ 2: 0.5 ~ 2: 0.5 to 2: 0.5 to 2: 0.5 to 2 by weight. In the step of obtaining the mixed extract-1, water at a temperature of 85 ° C to 100 ° C is added at a volume ratio of 6 to 10 times the dry weight (l / kg) of Korean red ginseng and natural plants, And extracts the mixed extract-1 containing the useful components of Korean red ginseng and natural plants (gigobia, seokchangpo, wusul, raw paper, gosam, yugunpyu, raw persimmon) by hot water extraction within 6 to 12 hours.
In addition, the mixed extract-2 can be subjected to hot-water extraction using licorice and chrysanthemum at a weight ratio of 1: 0.5 ~ 2. In the step of obtaining the mixed extract-2, the water is added at a volume ratio of 6 to 10 times the dry weight (l / kg) Extracting hot water in the range of 12 hours gives mixed extract-2 containing the beneficial ingredients of licorice and chrysanthemum. In addition, in the step of obtaining the mixed extract-3, the mixed extract-1 and the mixed extract-2 may be mixed at a weight ratio of 1: 0.2 to 5 to obtain a mixed extract-3.
Preparation of second extract
According to a second aspect of the present invention, there is provided a method for producing a mixed extract, comprising: obtaining a mixed extract-1 obtained by hot water extraction of red ginseng and rhizome; Obtaining a mixed extract-2 obtained by extracting licorice and chrysanthemum with hot water; Obtaining a mixed extract-3 obtained by mixing the mixed extract-1 and the mixed extract-2; A first purification step of passing the mixed extract-3 through a filtration apparatus equipped with an activated carbon filter to adsorb and remove pesticide and heavy metal components; A second purification step of separating the mixed extract-3 from the inert carbohydrate and the colloidal suspension using a centrifuge; A third purification step of passing the mixed extract-3 through a filtration device equipped with a bacteria elimination membrane to remove bacterial microorganisms; The present invention also provides a method for preparing red ginseng and natural plant extract comprising the step of subjecting the purified mixed extract-3 to at least one selected from the group consisting of concentration and drying.
According to a more specific embodiment, red ginseng (Korean red ginseng) and yugaeko are mixed extract-1, licorice and chrysanthemum are mixed extract-2, and physiologically active substances present in mixed extract-1 and mixed extract- After cooling to room temperature, mixed extract-1 and mixed extract-2 were mixed to prepare Korean red ginseng and three kinds of natural plant mixture extract-3.
In order to remove the pesticide residues and heavy metal components remaining in the mixed extract-3, the mixed extract-3 was passed through a filtration apparatus equipped with an activated carbon filter to adsorb and remove the pesticide and heavy metal components, To remove carbohydrates and colloidal suspensions, inert carbohydrates and colloidal suspensions were removed using ultracentrifugation centrifuges at 10,000 rpm or higher (e.g., 10,000 to 15,000 rpm) per minute, and the bacterial microorganisms (TFF-type micro-filtration ion system) equipped with a membrane of 0.45 ㎛ in size to remove the bacterial microorganisms by collecting the liquid permeated by feeding the mixed extract-3 Korean red ginseng and three kinds of natural plant mixed extract-3 are obtained.
Finally, purified Korean red ginseng and three kinds of natural plant mixed extract-3 are concentrated by using a pressure-reducing concentrator according to the purpose of use to obtain a concentrate of mixed extract-3 of a certain concentration or by using freeze-drying or spray drying apparatus To obtain Korean red ginseng and three kinds of mixed extract powder. (Preparation of Second Extract)
At this time, the mixed extract-1 can be subjected to hot-water extraction using red ginseng (Korean red ginseng) and yugun peel at a weight ratio of 1: 0.5 ~ 2. In the step of obtaining the mixed extract-1, water at a temperature of 85 ° C to 100 ° C is added at a volume ratio of 6 to 10 times the dry weight (l / kg) of Korean Red Ginseng and Root Root By extracting hot water within the range of 6 to 12 hours, a mixed extract-1 containing the useful components of Korean red ginseng and yugun can be obtained.
In addition, the mixed extract-2 can be subjected to hot-water extraction using licorice and chrysanthemum at a weight ratio of 1: 0.5 ~ 2. In the step of obtaining the mixed extract-2, the water is added at a volume ratio of 6 to 10 times the dry weight (l / kg) Extracting hot water in the range of 12 hours gives mixed extract-2 containing the beneficial ingredients of licorice and chrysanthemum. In addition, in the step of obtaining the mixed extract-3, the mixed extract-1 and the mixed extract-2 may be mixed at a weight ratio of 1: 0.2 to 5 to obtain a mixed extract-3.
Composition
The composition according to the present invention comprises the first extract and / or the second extract as described above. The first extract is prepared by the above-mentioned method, and contains red ginseng (Korean red ginseng) and nine specified natural plant extracts. That is, the first extract contains extracts of useful components of red ginseng (Korean red ginseng), gigobipi, sechangpo, wusel, raw paper, gosam, yuukee, raw persimmon, licorice and roots. In addition, the second extract is prepared by the above-mentioned method, and contains red ginseng (Korean red ginseng) and three specified natural plant extracts. That is, the second extract contains a useful component extract of red ginseng (Korean red ginseng), yugun pei, licorice, and roots.
In addition, the composition according to the present invention may further comprise a natural mineral salt in addition to the first extract and / or the second extract. At this time, the composition containing the first extract may be useful for preventing hair loss and / or for promoting hair growth, for example, applying scalp and / or hair. In addition, the composition containing the second extract may be useful for skin aging prevention, skin regeneration, anti-inflammation and / or antimicrobial use, for example, for cosmetics and / or medicines.
In addition, the composition and application of the composition according to the present invention are not particularly limited. The composition according to the present invention may have, for example, formulations such as liquid, powder, gel and the like. The composition according to the present invention may also be applied to scalp and / or hair such as shampoo, rinse, soap, lotion, cream, skin and / or oil for the purpose of preventing hair loss and / May be a cosmetic composition. In addition, the composition according to the present invention may be applied to the face and skin such as body wash, soap, cream, skin, foundation and / or oil for the purpose of skin aging prevention, skin regeneration, anti-inflammation and / And may be a cosmetic composition to be used. In addition, the composition according to the present invention may be various pharmaceutical compositions (medicines and pharmaceutical raw materials, etc.), but is not limited to those listed above.
Hereinafter, embodiments of the present invention will be exemplified. The following examples are provided to illustrate the present invention in order to facilitate understanding of the present invention, and thus the technical scope of the present invention is not limited thereto.
[Example 1]
[1] Production of Korean red ginseng and natural plant extracts effective for promoting hair growth
(1) After processing Korean red ginseng, Gyobolpyu, Seokchangpo, Woosel, raw paper, Gosam, Yukunpi, and Bokwanghwi into 5mm long pieces respectively, Korean Red Ginseng, Gyungpopi, Seokchangpo, 1: 1: 1: 1: 1: 1: 1 in a weight ratio of 1: 1: 1: 1: 1 and put into a nonwoven fabric.
(2) Drying weight (ℓ / ㎥) of Korean red ginseng and natural plants in water of 90 ℃ as extraction condition suitable for physical properties of Korean red ginseng and natural plants (Gyeongbori, Seokchangpo, (Gypsum, seokchangpo, wusul, raw, gosam, yuuki, and yujiji) were extracted by hot water extraction for about 10 hours from the time when extraction temperature (90 ℃) Was obtained.
(3) Licorice and Rhododendron were processed to a length of about 5 mm, respectively, and then liquorice pieces and rhododendrons were mixed at a weight ratio of 1: 1 and placed in a nonwoven fabric.
(4) Extraction temperature (90 ℃) was reached by adding water at 90 ℃ to the dry weight (ℓ / ㎏) ratio of licorice and phlox at 8 times volume ratio, And extracted with hot water for 10 hours.
(5) The mixed extract-1 obtained in the above (2) and the mixed extract-2 obtained in (4) were put into a refining tank and mixed to prepare a mixed extract-3. Then, the residual heavy metals, And then adsorbed and removed heavy metals and pesticide components by passing them through an activated carbon filter.
(6) In order to remove inactive carbohydrate and colloidal suspensions floating in the mixed extract-3, the mixed extract-3 was passed through a rotating speed (10,000 rpm) while keeping the temperature of the mixed extract- To obtain a red ginseng and a natural plant mixed extract - 3.
(7) In order to remove the bacterial microorganisms remaining in the mixed extract-3, the mixed extract-3 was fed to a TFF-type micro-filtration system equipped with a membrane of 0.45 쨉 m in size (Korean red ginseng) and 9 kinds of natural plant mixed extract - 3 were obtained. At this time, in order to maximally recover the amount of the mixed extract to be permeated, the liquid to be retentate was mixed with the purified water several times and feeding was repeated.
(8) The finally purified mixed extract-3 was put into a vacuum concentrator and concentrated under reduced pressure at a concentration of 70 ° C or less until the sugar meter reading reached 20brix to obtain a concentrated liquid. The obtained concentrate was frozen at -60 ° C And then heated to 45 캜 for 40 hours to vacuum-dry to obtain ginseng extracts (powders) of Korean red ginseng and nine natural plants, which are effective for promoting hair growth.
[2] Effect of Korean red ginseng and nine natural plant extracts
The following animal experiments were carried out in order to investigate the anti-hair loss and hair growth promoting effects of the mixed extracts of Korean red ginseng and nine natural plants produced by the method of [1] above.
(1) Experimental animals
rat (SD) was used for the experiment after adjusting for breeding condition for 1 week using 25 male 6 week old male. Until the experimental period, maintenance and management of experimental animals were maintained in an independent laboratory.
(2) Sample administration
A total of 25 mice were used in each of the control, diet, transdermal, and dietary groups (9, 8, and 8). The diets were prepared by mixing red ginseng and 9 kinds of mixed natural plant extracts in a normal diet. The 60 kg adult was mixed with 600 g of the daily intake in proportion to the body weight of 300 g, (20g / day / day). The transdermal application method was applied to the skin by spraying a certain amount of Korean red ginseng and 9 kinds of natural plant mixture (20brix) In the dietary administration group, a certain amount of distilled water was sprayed to give the same stress.
(3) Comparison of hair growth
Before the experiment, the dorsal hairs were shortly removed with an animal clipper. 1% testosterone (in ethanol) was soaked in cotton and applied to the hair removal area for 1 week to uniformly suppress hair growth of all experimental animals. After the testosterone transdermal application, Korean red ginseng and 9 kinds of natural plant feed were administered, and Korean red ginseng and 9 kinds of natural plant mixed extract samples were applied. The length of the hair growth was measured on the 12th day and 24th day after the sample administration, and the hair was repeatedly measured on the 24th day and then on the 10th day after the hair removal. After the administration of the sample, it was judged visually and the hair growth index (hair growth index) was measured and quantified (see Table 1). The results of hair growth comparison and the percentage of fully-hatched individuals are shown in [Table 2] and [Table 3], respectively, and digital images are shown in FIG.
Hair growth
Hair growth
* Display value: Mean ± SD (SD), and the value (%) shows the increase rate relative to the control
* Percentage of total hatchlings per total population by experimental group
(4) Experimental results
In the experiment using Rat (SD), the total number of hatching was increased 4 to 5 times and the number of hatching increased by 2 times (100% It is considered that the extract of natural plant mixture promotes hair growth significantly.
The beneficial components of Korean red ginseng, gigobipi, seokchangpo, woosil, ginseng, gosam, yukuni, bijiji, licorice, and chrysanthemum promote the secretion of hormones and metabolic functions and increase the blood flow in the scalp, It strengthens the hair follicle and promotes hair growth. The beneficial ingredients derived from 9 kinds of natural plants including Korean red ginseng have the effect of killing parasites such as hair follicles and hair follicles existing in the scalp and hair follicle as well as bacterial bacteria and thereby relieving inflammation and healing. It removes the fat and dirt that are trapped in the skin, and it helps the scalp to stay healthy by having the effect of smooth skin breathing through the pores. In general, the hair loss phenomenon is caused by temporary stress that can be cured naturally when the cause of hair loss is eliminated, and hair loss due to the taking of a specific drug, and by genetic causes caused by the reaction with the active hormone male hormone progesterone and genetic factors in the scalp There is hair loss.
However, recent hair loss phenomenon is caused by complicated and various factors such as an increase in diet, cumulative environmental hormones, excessive entrance examination, cumulative mental stress due to competition for social survival such as employment and unemployment, and decrease in physical exercise, The trend is shifting from the age of adolescence to the age of growth. The cause of premature hair loss is the decrease of hormone secretion amount related to the tissue and cell growth of the human body from the infant until the growth stage of about 20 years of age due to the above complex factors. Therefore, Korean red ginseng and 9 kinds of mixed natural plant extract of the present invention keep scalp and hair clean and smooth the nutrient supply to the scalp, and also participate in metabolism through the blood vessels and stimulate the pituitary gland, It stimulates the secretion of hormones and induces the growth of hair follicle cells, so that it can be said that the effect of making the hair grow thick and healthy.
[Example 2]
[1] Prevention of skin aging and regeneration, production of anti-inflammatory and anti-inflammatory effect of Korean red ginseng and natural plant extracts
(1) Korean red ginseng and yugun pei were processed to a length of about 5 mm each, and Korean red ginseng and yugunipi were mixed in a weight ratio of 1: 1, put into a nonwoven fabric pad, and then put into a hot water extraction tank.
(2) The extraction conditions suitable for the physical properties of Korean red ginseng and yugi kei were 90 ℃ water and about 8 times volume ratio of dry weight (ℓ / ㎏) ) Was extracted for about 10 hours by hot water extraction to obtain a mixed extract of the useful components of Korean red ginseng and yugunghi.
(3) Licorice and Rhododendron were processed to a length of about 5 mm, respectively, and then liquorice pieces and rhododendrons were mixed at a weight ratio of 1: 1 and placed in a nonwoven fabric.
(4) Extraction temperature (90 ℃) was reached by adding water at 90 ℃ to the dry weight (ℓ / ㎏) ratio of licorice and phlox at 8 times volume ratio, And extracted with hot water for 10 hours.
(5) The mixed extract-1 obtained in the above (2) and the mixed extract-2 obtained in (4) were put into a refining tank and mixed to prepare a mixed extract-3. Then, the residual heavy metals, And then adsorbed and removed heavy metals and pesticide components by passing them through an activated carbon filter.
(6) In order to remove inactive carbohydrate and colloidal suspensions floating in the mixed extract-3, the mixed extract-3 was passed through a rotating speed (10,000 rpm) while keeping the temperature of the mixed extract- To obtain a red ginseng and a natural plant mixed extract - 3.
(7) In order to remove the bacterial microorganisms remaining in the mixed extract-3, the mixed extract-3 was fed to a TFF-type micro-filtration system equipped with a membrane of 0.45 μm in size for sterilization By collecting the permeate solution, Korean red ginseng and 3 kinds of natural plant mixed extract - 3 in which bacterial microorganisms were removed were obtained. At this time, in order to maximally recover the amount of the permeate mixed extract, the liquid to be retentate was mixed with the purified water several times and feeding was repeated.
(8) The finally purified mixed extract-3 was put into a vacuum concentrator and concentrated under reduced pressure at a concentration of 70 ° C or less until the sugar meter reading reached 20brix to obtain a concentrated liquid. The obtained concentrate was frozen at -60 ° C , Followed by vacuum drying for 40 hours at a temperature of 45 ° C to prepare skin-aging prevention and regenerating effect, and three kinds of Korean red ginseng and natural plant-derived mixed powder (powder) having anti-inflammatory and antibacterial effects.
[2] Preparation of mixed aqueous solution samples (composition) of mixed extract and natural mineral salt
(1) natural mineral salts
The constituents of the natural mineral salts are shown in Table 4 below.
(2) preparation of a mixed sample (composition) of Korean red ginseng and three kinds of natural plant extracts and natural mineral salts
Sample 1: 100 ml of completely sterilized distilled water was used as
- Sample 2: 2 ml of the Korean Red Ginseng and the three kinds of natural botanical extracts (20brix) of 65Brix were added to 100 ml of completely sterilized distilled water to prepare a mixed extract of Korean red ginseng and a useful ingredient of natural plant as a sample 2 .
Sample 3: 2 g of a natural mineral salt was weighed into 100 ml of completely sterilized distilled water, and stirred with a stirrer until the natural mineral salt was completely dissolved, to obtain a sample 3 as an aqueous solution of a natural mineral salt.
- Sample 4: 2 ml of Korean red ginseng mixed with 20Brix and 3 kinds of mixed natural plant extracts were weighed in 100 ml of completely sterilized distilled water, and 2 g of natural mineral salt was weighed and weighed in an aqueous solution of Korean red ginseng and three kinds of natural plant mixture And mixed with a mixture of Korean red ginseng and three kinds of natural plant mixed extracts and a natural mineral salt as a sample 4, which was obtained by stirring with a stirrer until the natural mineral salt was completely dissolved.
[3] Efficacy test of each sample (composition)
(1) Cell regeneration effect experiment
In order to compare the cell regeneration ability of each of the above test samples, four portions of the same size were prepared on one animal using a scalpel to stop the bleeding with disinfecting gauze. 2 is a photograph showing a wound to be applied to each sample (
FIG. 3 is a photograph of the wound of the same position photographed at the 0th week of the experiment, taken three weeks after the lapse of three weeks, while the wound of a, b, c, The recovery of the wound at one point is shown.
FIG. 4 is a photograph taken at 7 weeks after the wound of the same position photographed at the 0th week of the experiment. It is assumed that the wound of a, b, c, And the recovery state of the wound at the time point.
As shown in FIGS. 2 to 4, when the prepared four kinds of samples were used to visually observe the recovery state according to the elapsed time for the same wound, the recovery state of the wound a using distilled water was very slow The wounded d treated with the mixture of red ginseng and three natural plant mixed extracts and the natural mineral salt aqueous solution showed a rapid recovery rate to the extent that the scratch marks were very slight after 7 weeks of visual inspection. In addition, it can be known that wound b and c treated with mixed Korean red ginseng and three natural plant mixed extracts and natural mineral salt aqueous solution are recovered faster than wound a treated with distilled water. However, Korean red ginseng and three natural plant mixtures The recovery rate is slightly slower than that of the wound d treated with the aqueous solution mixed with the extract and the natural mineral salt, as observed with the naked eye.
(2) Antioxidant effect test
To investigate the antioxidative effects of the
As shown in FIGS. 5 to 8, the amount of generated hydrogen peroxide (H 2 O 2 ), which is an oxidizing substance generated in the mitochondrial cells containing the four kinds of samples, was measured by the amount of current generated through the electrolytic apparatus the comparison, as can be seen were the highest number of hydrogen peroxide (H 2 O 2) generated in the mitochondria, the cell containing the distilled water and red ginseng and in the least amount in the three kinds of natural plant mixture extract, natural mineral salt mixed aqueous solution sample of hydrogen peroxide (H 2 O 2 ) has occurred. These results suggest that the production of hydrogen peroxide (H 2 O 2 ), which is an oxidizing substance that causes skin aging, is remarkable in that the mixed aqueous solution of red ginseng and three natural plant mixed extracts and natural mineral salts produces active oxygen in the cellular metabolism Inhibition and conversion to oxygen and water.
(3) Sterilization effect experiment
Escherichia coli and Staphylococcus aureus were cultured in Brain Heart Broth (DIFCO), and then cultured bacteria were diluted to adjust the initial number of bacteria to 10 5 to 10 6 CFU / ml. When the test solution was added to 20 ml of the test solution (raw solution), and the mixture was allowed to stand at room temperature for 1 hour, the bacterial count was measured to determine the rate of sterilization to the initial number of bacteria. The number of bacteria counted as a control of physiological saline was expressed as the number of initial bacteria. However, in the initial dilution stage of all experiments, neutralization was carried out using D / E Neutralizing Broth (DIFCO). When bacteria were grown in the medium, the number of bacteria on the medium was multiplied by the dilution factor, In the absence of bacterial growth in the medium, multiplying by the dilution factor in the neutralization stage, and in the case of no growth of bacteria in the medium, multiplied by the dilution factor in the neutralization stage and expressed as "less than 10 (<10)". The viable count was calculated according to [Equation 1] and the rate of bacterial reduction was determined according to [Equation 2].
1) Calculation of viable count
[Formula 1]
N = C x D
N: number of living cells
C: Number of colonies (average value of two colonies)
D: Dilution factor (dilution factor of diluent)
2) Sterilization reduction rate (%) calculation
[Formula 2]
R (%) = [(A-B) / A] x 100
R: sterilization reduction rate
A: Initial number of bacteria
B: Number of bacteria after a certain time
3) Experimental results
The experimental results are shown in Table 5 below and in FIG. 9 attached hereto.
First, the bactericidal test for E. coli was reduced to [<10 (less than 10) CFU / ㎖] after 1 hour treatment with the initial inoculum [4.3 × 10 5 CFU / ㎖]. In addition, the sterilization test for S. aureus was reduced to [<10 (less than 10) CFU / ㎖] after 1 hour treatment with the initial inoculum [3.1 × 10 5 CFU / ㎖].
As shown in the above results, the germicidal activity of the bacterial microorganisms represented by the mixed extracts of Korean red ginseng, yuukie, licorice, and yellowtail was very good.
(4) Anti-inflammatory effect experiment
1) Cell culture
RAW 264.7 mouse macrophages were purchased from the Korean Cell Line Bank (KLCB, Seoul), and DMEM medium containing 1% penicillin-streptomycin and 10% FBS was used. The cells were cultured in an environment of 37 ° C and 5% CO 2.
2) Cell viability measurement
Cell viability was measured by 5- (3-carboxymethoxyphenyl) 2H-tetrazolium inner salt (MTS) assay. RAW 264.7 mouse macrophage cells were seeded at 1 × 10 4 cells / well in a 96-well plate and the samples were treated for 18 hours at concentrations of 0, 10, 25, 50, 100, 250, 500, 750 and 1000 μg / . After incubation at 37 ° C in a 5% CO 2 incubator for 4 hours, the absorbance was measured at 450 nm using a microplate reader (DYNEX, Opsys MR, USA) Cell viability was expressed as a percentage in the untreated wells.
3) NO inhibition effect measurement
The nitrite concentration in cell culture medium of RAW 264.7 cells induced by LPS was measured by Griess Reagent to determine how much NO suppressed the sample. RAW264.7 cells were pre-treated at a concentration within a concentration that did not compromise the viability of cells, and after 1 hour, treated with 1 μg / ml of LPS and cultured for 18 hours. 50 μl of the cell culture was mixed with the same amount of Griess Reagent, and reacted at room temperature for 10 minutes. Then, the absorbance at 540 nm was measured using a microplate reader (VersaMax, Molecular Devices, USA). A standard curve was obtained by dividing sodium nitrite by concentration and the NO concentration in the culture fluid was calculated in comparison with the absorbance of the sample.
4) Measurement of PGE2 production
PGE2 in the cell culture medium was measured to examine the degree of cytokine inhibitory effect of the sample. Commercial competitive enzyme immunoassay kit was purchased from R & D systems (Minneapolis, USA). RAW264.7 cells were pre-treated at a concentration within a concentration that did not compromise the viability of cells, and after 1 hour, treated with 1 μg / ml of LPS and cultured for 18 hours. 100 μl of the cell culture solution is loaded on a 96-well plate coated with goat anti-mouse, and 50 μl of each primary antibody solution and PGE2 conjugate are added at 4 ° C overnight. Washing buffer was used for washing 4 times. Substrate solution was treated with 200 μl of each reaction solution for 5 minutes, treated with 50 μl of stop solution, and absorbance at 450 nm was measured. The amount of PGE2 produced was expressed as the fold value for wells that were not treated with the sample.
<Experimental Results>
1) Cell viability measurement of Korean red ginseng and three asthmatic mixed extracts
Cell viability was measured using the MTS assay in order to measure the inhibitory effect of Nitric Oxide and PGE2 on the RAW 264.7 cells. The results are shown in the figure below. The cell viability was lowered to 80% or less at a concentration of 500 μg / ml for the CY sample and 750 μg / ml for all the other samples. Therefore, the experiment was carried out at a maximum concentration of 250 μg / ml for the CY sample and 500 μg / ml for the remaining samples. The results are shown in Fig.
2) Effect of Korean red ginseng and three kinds of mixed natural plant extracts on production of NO and PGE2
In order to investigate the anti - inflammatory effect of each sample, the inhibitory effect of Nitric Oxide and PGE2 was measured. First, to investigate the inhibitory effect of nitrite, induction of inflammation with LPS was performed and then the amount of nitric oxide produced was measured using Griess reagent. In almost all samples, the inhibitory effect of nitric oxide was shown in a concentration dependent manner. The inhibitory effect of Nitric oxide was in the order of Mat, BG, Via, HP, CY and LS according to the mixing ratio of Korean red ginseng and three natural plant mixed extracts. The results are shown in Fig.
In addition, the amount of PGE2 produced by LPS was measured, as shown in FIG. 12 attached. The results showed that PGE2 production was reduced in a concentration dependent manner. The effects were in the order of BG, Mat, Via, LS, HP and CY.
Therefore, in the case of Nitric Oxide and PGE2 production measured in RAW 264.7 cells, the Mat sample showed the best efficacy in Nitric Oxide, followed by BG and Via samples. Similarly, BG samples showed the best efficacy in the amount of PGE2 produced, followed by Mat and Via. This demonstrates the superiority of the Mat sample based on mathematical quantification, while the BG effect is superior in cell-based experiments, and the Via sample based on Cell viability is also shown to be superior in cell experiments. Korean red ginseng and three kinds of natural plant mixed extracts are considered to have excellent anti - inflammatory effect at the optimal blending ratio. [Table 6] shows the results according to the mixing ratio (weight ratio) of Korean red ginseng and natural plants.
As shown in the above examples, various ingredients and efficacies of Korean red ginseng and natural plants have been continuously clarified and identified. Therefore, only the food and medicinal materials have been limited to the quality of life for consumers Along with the change of natural-friendly consumption patterns, it has gradually become a core material in the cosmetic and skin grafting medicine industry. It is in harmony with the biological metabolism activation function of natural salt rich in human essential minerals The effect of Korean red ginseng and natural plant on the skin, that is, promoting the growth hormone secretion, promotes the growth of hair follicle and skin cells, smoothes blood flow through vascular dilation of capillary vessels distributed in the skin layer and removal of vascular waste The effect of energizing the hair follicle cells and skin cells, Antioxidant activity of cells is anticipated to be able to maximize skin aging prevention effect, antibacterial and anti-inflammatory effect, anti-allergic effect, lipid removal effect, hair loss prevention and hair growth effect, so that Korean red ginseng and natural plant- And can be developed as new and important functional materials for cosmetics and pharmaceuticals that can be applied to the skin, scalp and skin. Therefore, in the domestic cosmetics manufacturing industry, which has been dependent on expensive imported raw materials, we have developed functional cosmetics that can be applied to various scalp, hair, and skin using Korean red ginseng and natural plant mixed extracts. And it is expected to create a high value-added product market with high consumer preference in terms of quality both domestically and overseas.
Claims (8)
Obtaining a mixed extract-2 obtained by extracting licorice and chrysanthemum with hot water;
Obtaining a mixed extract-3 obtained by mixing the mixed extract-1 and the mixed extract-2;
A first purification step of passing the mixed extract-3 through a filtration apparatus equipped with an activated carbon filter to adsorb and remove pesticide and heavy metal components;
A second purification step of separating the mixed extract-3 from the inert carbohydrate and the colloidal suspension using a centrifuge;
A third purification step of passing the mixed extract-3 through a filtration device equipped with a bacteria elimination membrane to remove bacterial microorganisms; And
The method for preparing red ginseng and natural plant extracts according to any one of claims 1 to 3, wherein the purified mixed extract (3) is subjected to a post-treatment step in which at least one selected from the group consisting of concentration and drying is advanced.
Obtaining a mixed extract-2 obtained by extracting licorice and chrysanthemum with hot water;
Obtaining a mixed extract-3 obtained by mixing the mixed extract-1 and the mixed extract-2;
A first purification step of passing the mixed extract-3 through a filtration apparatus equipped with an activated carbon filter to adsorb and remove pesticide and heavy metal components;
A second purification step of separating the mixed extract-3 from the inert carbohydrate and the colloidal suspension using a centrifuge;
A third purification step of passing the mixed extract-3 through a filtration device equipped with a bacteria elimination membrane to remove bacterial microorganisms; And
The purified mixed extract-3 is subjected to a post-treatment step in which at least one selected from the group consisting of concentration and drying is advanced to thereby produce a red ginseng and natural plant extract having skin aging prevention, skin regeneration, anti-inflammation or antibacterial effect Way.
In the step of obtaining the mixed extract-1, the red ginseng, giocarpus, joseongpo, wusel, raw, ginseng, yuukee, and raw persimmon are added to water at an extraction temperature of 85 to 100 캜 in a volume ratio of 6 to 10 times dry weight (l / And extracting the mixed extract-1 by hot water extraction within a range of 6 to 12 hours from the time when the extraction temperature reaches.
In the step of obtaining the mixed extract-1, red ginseng and root weevils are added to water at an extraction temperature of 85 ° C to 100 ° C at a volume ratio of 6 to 10 times the dry weight (l / kg) And extracting the mixed extract-1 by hot water extraction within the time range.
In the step of obtaining the mixed extract-2, licorice and phloxy are introduced into water at an extraction temperature of 85 ° C to 100 ° C at a volume ratio of about 6 to 10 times by dry weight (l / kg) And extracting hot water within a time range to obtain a mixed extract-2.
In the post-treatment step, the purified mixed extract-3 is added to a reduced pressure concentrator, and the concentrated liquid is obtained by concentration until the measured value of the saccharometry reaches 20brix under the reduced pressure condition of the concentration temperature of 70 ° C or less or the concentrated liquid is frozen at -60 ° C Followed by vacuum drying while raising the temperature to 45 캜 for the next 40 hours.
The composition for preventing hair loss, for promoting foaming, for preventing skin aging, for skin regeneration, for anti-inflammation or for antibacterial, further comprising a natural mineral salt.
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| KR20200011193A (en) * | 2018-07-24 | 2020-02-03 | 황상철 | Food compositions for skin regeneration, inflammation relief, moisturizing and health improvement and method for manufacturing the same |
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| KR20000031349A (en) | 1998-11-05 | 2000-06-05 | 박명규 | Hair tonic manufactured from ginseng and manufacturing method thereof |
| KR20020076834A (en) | 2001-03-30 | 2002-10-11 | 최동재 | Hair-restorer and it's making method |
| KR100982414B1 (en) | 2010-03-03 | 2010-09-15 | 유주상 | Composition for preservation of hair comprising acdrus asiaticus |
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