KR20160049750A - Fermented gongjindan composition and fabricating method thereof - Google Patents

Fermented gongjindan composition and fabricating method thereof Download PDF

Info

Publication number
KR20160049750A
KR20160049750A KR1020140147350A KR20140147350A KR20160049750A KR 20160049750 A KR20160049750 A KR 20160049750A KR 1020140147350 A KR1020140147350 A KR 1020140147350A KR 20140147350 A KR20140147350 A KR 20140147350A KR 20160049750 A KR20160049750 A KR 20160049750A
Authority
KR
South Korea
Prior art keywords
fermented
gongjindan
antler
composition
musk
Prior art date
Application number
KR1020140147350A
Other languages
Korean (ko)
Inventor
서기성
Original Assignee
주식회사 위드내추럴
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사 위드내추럴 filed Critical 주식회사 위드내추럴
Priority to KR1020140147350A priority Critical patent/KR20160049750A/en
Publication of KR20160049750A publication Critical patent/KR20160049750A/en

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/40—Cornaceae (Dogwood family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Insects & Arthropods (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Animal Husbandry (AREA)
  • Reproductive Health (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Disclosed in the present invention are a fermented oriental medicinal pill (Gongjindan) composition capable of improving an absorption ratio in bowels and a method for preparing the same. The fermented Gongjindan composition comprises extracts of fermented deer antlers, musk, Korean angelica and Cornus officinalis S. et Z. as active ingredients. The method for preparing a fermented Gongjindan composition comprises the steps of: mixing Cornus officinalis S. et Z., deer antlers, Korean angelica and musk with natural honey; fermenting the mixed materials; measuring and verifying the fermented materials; and packaging the measured and verified raw materials with gold foil for protecting pharmaceutical effects. According to the fermented Gongjindan composition and the method for preparing the same, it is possible to improve the absorption ratio in the bowels to allow Gongjindan to show unique effects thereof sufficiently. In other words, it is possible to obtain effects of anti-fatigue, protecting the liver and bowels, enhancing immunity and antioxidant activity, improving anticancer activity and enhancing intestinal lactobacillus.

Description

발효 공진단 조성물 및 그 제조방법{FERMENTED GONGJINDAN COMPOSITION AND FABRICATING METHOD THEREOF}FIELD OF THE INVENTION [0001] The present invention relates to a composition for fermentation,

발효 공진단 조성물 및 그 제조방법에 관한 것이다.A fermentation resonance section composition and a method for producing the same.

한의학에서는 질병이 야기되기 이전에 예방하는 예방치료의 개념이 강하였으며, 종래의 보약이 이러한 개념이었다. 이러한 보약들의 대표적인 한의학적 처방약인 공진단은 녹용, 당귀, 산수유, 사향으로 구성된 처방으로 공진단의 활용을 살펴보면 노화를 방지하고 질병을 예방하는 경우, 수술이나 큰 병으로 원기가 쇠약해진 경우, 정신적 신체적 과로로 기력이 저하된 경우, 만성 피로가 심하여 휴식으로도 회복이 더딘 경우, 선천적으로 체질이 약한 경우, 혈액순환 저하로 몸이 무겁고 저린 경우, 신경이 예민하여 어지럼증과 불면증이 있는 경우, 과다한스트레스와 음주로 간 기능이 약화된 경우 등에 유용하다고 알려져 있다. In Oriental medicine, the concept of preventive treatment to prevent disease was strong, and the conventional care was this concept. If you look at the use of resonance in a prescription composed of antler, angelica, corn oil, and musk, this is the typical oriental medicinal prescription medicine, which is a medicinal prescription medicine of these kind. If you prevent aging, prevent disease, If you are depressed, you are suffering from chronic fatigue, rest, recovery is slow, congenital weakness, blood circulation is low, body is heavy, nerves are sensitive, dizziness and insomnia, excessive stress and drinking It is known to be useful when liver function is weakened.

동의보감에는 “대체로 남자가 장년시기에 진기(眞氣)가 몹시 약한 것은 타고날 때부터 약하고 허한 것이 아니므로 성질이 조(燥)한 약재를 쓰지 말아야 한다. 음혈을 보한다고 하는 처방들에 약품은 많으나 약효가 매우 약하여 효력을 보기 어렵다. 다만 타고난 원기를 든든히 하여 신수와 심화가 잘 오르내리게 되면 오장이 스스로 조화되고 온갖 병이 생기지 않을 것이다. 이런 때에는 이 처방을 쓴다.”라고 되어 있고 녹용(졸인 젖을 발라 구운 것), 당귀, 산수유 각각 160g, 사향(따로 간 것) 20g을 가루 내어 술을 두고 쑨 밀가루풀로 반죽한 다음 벽오동씨 만하게 알약을 만들어 한번에 70-100알씩 데운 술이나 소금 끓인 물로 복용하게 되어 있다."In general, men should not use medicines that are temperamental in nature because their weakness is weak and unfavorable from the beginning of their life. There are many drugs in the prescriptions for seeing the blood, but the effect is very weak and it is hard to see the effect. However, if the innate spirit is strengthened and the soul and the deepening ascend and descend, the five will be harmonized and all kinds of diseases will not occur. I put this prescription at this time. ", I put 160g of each of antler, jujube and corn oil, and 20g of musk (I went separately) and put the liquor and kneaded with 쑨 flour paste. Then, To make 70-100 eggs at a time to drink boiled or boiled water is to drink.

그러나, 공진단이 장에서 흡수되는 비율이 낮은 경우 공진단 본연의 효능이 충분히 발휘되지 않는 문제가 있다.However, there is a problem that when the resonance end is absorbed in the intestine is low, the effect of the resonance end is not sufficiently exhibited.

장에서의 흡수율을 향상시킬 수 있는 발효 공진단 조성물 및 그 제조방법을 제공하는 것을 목적으로 한다. Which is capable of improving the absorption rate in the field of fermentation, and a process for producing the same.

상기와 같은 목적을 달성하기 위하여, 일 양상에 따른 발효 공진단 조성물은 발효 녹용, 사향, 당귀 및 산수유 추출물을 유효성분으로 포함한다.In order to achieve the above-mentioned object, the fermentation resonance-stage composition according to one aspect includes fermented antler, musk, angelica, and corn oil extract as an active ingredient.

다른 양상에 따른 발효 공진단 조성물의 제조방법은, 산수유, 녹용, 당귀, 사향을 천연꿀과 배합하는 단계, 배합한 원료를 발효하는 단계, 발효된 원료를 정량 검품하는 단계, 및 정량 검품된 원료를 약효 보호용 금박으로 포장하는 단계를 포함한다. According to another aspect of the present invention, there is provided a method for producing a fermented resonance-stage composition, comprising the steps of: mixing natural oil with corn oil, antler, angelica grisea and musk; subjecting the blended raw material to fermentation; quantitatively inspecting the fermented raw material; And packaging them with protective gold foil.

발효 공진단 조성물 및 그 제조방법을 이용하면, 장에서의 흡수율을 향상시켜 공진단 본연의 효능을 충분히 발휘할 수 있는 효과를 얻을 수 있다. By using the fermentation resonance-stage composition and the production method thereof, it is possible to obtain an effect of enhancing the absorption rate in the intestine and sufficiently exhibiting the effect of the original resonance-stage.

즉, 항피로 및 간장 보호 효과, 면역증강 및 항산화증강 효과, 항암효과를 증강하는 효능 및 장 내 유산균을 증강하는 효능을 얻을 수 있다. That is, the anti-fatigue and hepatoprotective effect, the immunity enhancement and the antioxidant enhancement effect, the anticancer effect enhancing effect and the intestinal lactic acid bacteria enhancement effect can be obtained.

도 1은 발효 공진단 조성물의 제조방법의 일례를 나타낸 순서도이다. 1 is a flow chart showing an example of a method for producing a fermentation resonance-stage composition.

이하 도면을 참조하여 발효 공진단 조성물 및 그 제조방법을 더욱 상세히 설명한다. BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, a fermented resonance section composition and a method for producing the same will be described in detail with reference to the drawings.

발효 공진단은 다음과 같은 세 가지의 장점이 있다. The fermentation resonance band has three advantages:

첫째, 약재의 효능을 향상시키기 위하여 약재를 찌고 말리는 과정, 즉 법제 공정을 거친다. First, in order to improve the efficacy of the medicinal product, it is subjected to a process of steaming and drying the medicinal material, that is, a legal process.

둘째, 발효숙성 공정을 도입하였다. 공진단을 발효숙성하게 되면 소화흡수가 용이하게 되어 공진단의 효능이 더욱 향상될 수 있다. Second, the fermentation aging process was introduced. When the resonance end is fermented and aged, digestion and absorption are facilitated, and the effect of the resonance end can be further improved.

셋째, 유기농 한약을 원료로 사용한다. 녹용은 러시아 원용의 최상단부(분골)를 사용하고, 당귀는 유기농 국산 당귀, 산수유는 유기농 국산 산수유를 사용할 수 있다. 또한, 사향은 식약청 심의를 필한 정품 사향을 사용한다. Third, organic herbal medicine is used as raw material. The top part of Russian noodles (crustacean) is used for antler, and Angelica gigantis for Angelica gigas, and organic noodle oil for organic acid. In addition, the musk uses genuine musk which has been deliberated by the KFDA.

녹용의 경우, 사슴의 뿔은 4개의 주요 부분인 분골, 상대, 중대, 하대로 나눌 수 있다. 분골은 녹용의 최상층부로 절단면 테두리에 까맣고 굵게 기름띠가 형성되어 있으며, 대체로 복숭아빛의 색상을 띤다. 또한, 굴기에 관계없이 치밀한 조직과 성장호르몬이 함유되어 있다. In the case of antler, the antlers of the deer can be divided into four main parts: the crust, the opponent, the middle, and the bottom. The crest is the top layer of the antler, which has a black and thick band of oil on the cut edge and usually has a peach color. It also contains dense tissues and growth hormones, regardless of their growth.

산수유는 육이 많고 색깔이 밝은 것이 상품이다. 산수유는 너무 일찍 수확해도 또 너무 늦게 수확해도 약력이 떨어지는 점을 고려하여, 10월 말에서 11월 경에 수확한 것을 사용함으로써 약효를 극대화할 수 있다. Corn oil is a product that has a lot of meat and a bright color. Considering the fact that corn sour milk is too early or too late to be harvested, its efficacy can be maximized by using the harvested product from the end of October to around November.

당귀는 10-11월에 수확한 뿌리 부분을 사용한다. 잔뿌리가 많지 않고 몸통이 굵으며 잘라냈을 때에 속살이 하얗고 끈기가 있어서 진득한 것을 사용하는 것이 바람직하다. The rootstock is harvested in October-November. There are not many roots, the body is thick, and when cut off, it is desirable to use the one which is white because it is white and has tenacity.

발효 공진단의 종류에는 발효 사향 공진단, 발효 무가당 공진단, 발효 침향 공진단이 포함된다.Types of fermentation resonance stages include a fermented musk deodorant, a fermented sugar-free resonance stage, and a fermentation-induced resonance stage.

발효 사향 공진단은 사향을 사용한 공진단으로, 상시 복용할 수 있는 공진단이다. 한현, 사향의 함량을 증량하는 경우, 강하고 신속한 효과를 얻을 수 있다.  The fermented musk resonance stage is a resonance stage using musk and is a resonance stage that can be taken at any time. When the content of one hyeon and musk is increased, a strong and rapid effect can be obtained.

발효 무가당 공진단은 꿀(봉밀) 첨가 없이 제조함으로써, 당뇨병 등 혈당에 민감한 환자가 복용하는 데에 문제가 없도록 한 공진단이다.The fermentation-free sugar-free resonance band is a resonance band that is manufactured without the addition of honey (barley) so that the patient who is sensitive to blood sugar such as diabetes does not have any problem in taking it.

발효 침향 공진단은 사향 대신 침향을 사용한 공진단을 말한다.The fermented leaning resonance stage refers to a resonance stage using an aeration instead of a musk.

발효 공진단의 주성분인 발효녹용의 효능증강 효과는 다음과 같다. The effect of enhancing the fermented antler, which is the main component of the fermentation resonance stage, is as follows.

먼저, 항피로 및 간장 보호 효과가 있다. First, it has anti-fatigue and hepatoprotective effects.

발효녹용의 추출율과 생리활성을 증가시키기 위해 녹용을 발효하는 활생균을 왕겨에서 검색할 수 있다. In order to increase the extraction rate and physiological activity of fermented antler, active antler fermenting antler can be retrieved from the rice husk.

검색된 Bacillus종 중에서 가장 강력하게 녹용을 분해하는 활생균은 Bacillus KH-07이었으며, 발효녹용의 상청액 추출수율이 가장 높았다. Among the Bacillus species detected, Bacillus KH-07 was the most active antioxidant to degrade the antler, and the highest yield of the fermented antler extract was obtained.

생화학적 분석과 16S rDNA 서열분석으로 Bacillus KH-07은 Bacillus licheniformis에 속하였다. KH-07 발효녹용은 처리하지 않은 녹용과 비교하였을 때 항피로 효과가 2-3배 높았다. KH-07 발효녹용은 생쥐 간손상을 개선하였다. 따라서 녹용의 추출율과 생리 활성은 KH-07 발효로 증가된다. Biochemical analysis and 16S rDNA sequence analysis indicated that Bacillus KH-07 belonged to Bacillus licheniformis. The antihypertensive effect of KH-07 fermented antler was 2-3 times higher than that of untreated antler. KH-07 fermented deer antler improved the liver damage. Therefore, the extraction rate and physiological activity of antler are increased by KH-07 fermentation.

다음으로, 면역증강 및 항산화증강 효과가 있다. Next, there is the immunity enhancement and the antioxidant enhancement effect.

녹용의 효율을 높이고 새로운 약리효과를 기대하기 위해 녹용을 분해하는 미생물을 탐색하고, 선정된 미생물을 이용하여 발효시킨 녹용에 대하여 생리활성을 측정할 수 있다. In order to increase the efficiency of the antler, and to expect a new pharmacological effect, the microorganism decomposing the antler can be searched and the physiological activity can be measured against the antler which has been fermented using the selected microorganism.

Bacillus sp., Lactobacillus sp. 및 버섯균사체 중 녹용발효에 적합한 균주로 B. subtilis KH-15, SCB-3과 버섯 균사체인 Cordyceps militaris, Phelinus linteus, Inonotus obliquus 26136, Inonotus obliquus 26147을 이용하여 발효녹용을 제조할 수 있다. Bacillus sp., Lactobacillus sp. Fermented antler can be prepared by using B. subtilis KH-15, SCB-3 and mushroom mycelium Cordyceps militaris, Phelinus linteus, Inonotus obliquus 26136 and Inonotus obliquus 26147, which are suitable for the antler fermentation among mushroom mycelia.

그 결과, 녹용추출물에 비하여 녹용 발효물은 uronic acid, S-GAG, sialic acid 등 생리활성물질을 많이 함유하였으며, 항보체 활성과 라디칼 소거능이 증진되는 것을 확인하였다. As a result, compared with the antler extract, the antler dextrose contained a large amount of physiologically active substances such as uronic acid, S-GAG and sialic acid, and it was confirmed that anti-complement activity and radical scavenging ability were enhanced.

따라서, 녹용 자체가 지니는 조혈작용 등 생리활성 외에 항보체 활성처럼 새로운 활성이 발현될 수 있을 뿐 아니라, 라디칼 소거능처럼 기존의 활성을 증진시키는 효과를 가지고 있음을 확인하였다. Therefore, it has been confirmed that not only new activity can be expressed as anticonvulsant activity besides physiological activity such as antihypertensive action of antler itself, but also has an effect of promoting existing activity such as radical scavenging ability.

다음으로, 항암효과를 증강하는 효능이 있다. Next, it has an effect of enhancing the anticancer effect.

복수암 생쥐에 대한 발효녹용의 항암작용에 대하여 연구하였다. Anticancer effect of fermented antler was investigated in the mouse of multiple cancers.

녹용 및 Bicillus P-92를 이용하여 발효시킨 녹용에 대하여 아미노산 및 TLC 양상의 변화 및 복수의 Sarcoma 180을 이식한 생쥐에 대한 항암효과를 조사한 결과 발효녹용에서의 spot의 크기가 훨씬 컸고 아미노산도 6배 정도 많은 것으로 나타났다. The anticancer effects of antler and fermented antler of Bicillus P-92 were investigated. The results showed that the spot size in fermented antler was much larger and the amino acid content was 6 times Respectively.

또한 항암효과에 있어서도 녹용보다 발효녹용이 더 높은 생존기간과 생존율을 보이는 것으로 나타나 생쥐의 복수암에 대한 항암효과는 녹용을 발효시킴으로써 더 증가시킬 수 있다. In addition, anticancer efficacy showed a higher survival rate and survival rate than fermented antler, indicating that anticancer effects on the cancer of mice can be further increased by fermenting antler.

다음으로, 유산균 증강 효능이 있다. Next, there is an effect of enhancing the lactic acid bacteria.

녹용의 발효와 생리활성을 연구하였다. Fermentation and physiological activities of antler were investigated.

녹용을 발효하는 바실러스 P-02를 장내세균으로부터 분리하고, 발효녹용처리한 생쥐와 비처리 생쥐에 나타난 생물활성, carbon clearance 및 젖산균의 성장활성 등을 비교하여 발효에 의해 증가하는 녹용의 생물활성 검토를 수행한 결과, 발효녹용의 경우 유산균이 증강되는 효능을 확인할 수 있었다. Studies on the biological activity of antler, which is increased by fermentation, by comparing the biological activity, carbon clearance and growth activity of lactic acid bacteria in fermented antler and non-fermented rats treated with Bacillus P-02, As a result, it was confirmed that the effect of fermented antler was enhanced.

발효 공진단 제조시의 특징 및 주의사항은 다음과 같다. The characteristics and precautions of the fermentation process are as follows.

공진단은 탕약과 다르게 달여 먹는 것이 아니고 약재를 미세분말하여 제조한다. 즉, 복용하기 용이하고 흡수가 잘되도록 환으로 제조하여 복용하므로, 제조 과정과 한약재의 품질 및 청정성이 중요하다. 또한, 공진단에 가장 중요한 사향의 진품 여부 및 제조 용량의 준수가 중요하게 된다. The resonance stage is made by finely pulverizing the medicinal material, rather than eating it in a different manner from the sweet potion. That is, it is important that the manufacturing process and the quality and cleanliness of herbal medicines are made by taking the medicament so as to be easily taken and absorbed. In addition, it is important to observe the authenticity of the musk most important to the resonance stage and the manufacturing capacity.

도 1은 발효 공진단 조성물의 제조방법의 일례를 나타낸 순서도이다. 1 is a flow chart showing an example of a method for producing a fermentation resonance-stage composition.

도 1에서 나타낸 바와 같이, 발효 공진단 조성물을 제조하기 위하여, 먼저 산수유, 녹용, 당귀, 사향을 천연꿀과 배합하는 단계(100)가 수행된다. As shown in Fig. 1, in order to prepare a fermented resonant zone composition, step (100) is first carried out by blending corn oil, antler, angelica and musk with natural honey.

다음으로, 배합한 원료를 발효하는 단계(110)가 수행된다. 배합한 원료는 3-4주 발효될 수 있다. Next, step 110 of fermenting the blended raw material is performed. The blended raw materials can be fermented for 3-4 weeks.

다음으로, 정량을 검품하는 단계(120)가 수행된다. 정확한 효능 및 효과를 위해서는 정량 검품 단계가 매우 중요하다. Next, step 120 of inspecting the quantities is performed. The quantitative inspection step is very important for the correct efficacy and effectiveness.

다음으로, 약효 보호용 금박으로 포장하는 단계(130)가 수행된다. Next, step 130 of wrapping with a medicinal-effect-protecting gold foil is carried out.

약효 보호용 금박으로 포장된 공진단은 다시 종이 재질 등으로 한 번 더 포장될 수 있다. 또한, 개별 포장된 공진단은 전용 상자 등 용기에 넣어 보관될 수 있다. The resonance band packed with medicinal gold foil can be packed once again with paper or the like. In addition, the individual packaged resonance stages can be stored in a container such as a dedicated box.

발효 공진단은 다음과 같이 복용될 수 있다. The fermentation resonance stage can be taken as follows.

먼저, 일반 성인은 하루 1환씩 복용한다. 소아는 성인 몸무게(50kg 기준)에 비례하여, 1환을 여러 차례 나누어 복용한다.First, general adults take one pill per day. Pediatrics are divided into several doses in proportion to adult body weight (50kg standard).

빠른 체력이나 신속한 개선이 목적인 경우에는 하루 2환씩 복용할 수 있다. If you need fast stamina or rapid improvement, you can take 2 rounds a day.

복용 기간의 측면에서, 근본적인 체력회복과 개선이 목적인 경우에는 1개월 또는 3개월 간 연속으로 복용한다. In terms of duration of use, if you are intending to recover and improve your physical fitness, take one or three consecutive months.

일시적인 체력 보강과 개선이 목적인 경우에는 10일 연속 복용, 또는 1개월 간 2-3일에 1환씩 복용할 수 있다. If temporary physical strength improvement and improvement are aimed at, it can take 10 consecutive days, or one circle every 2-3 days for one month.

한편, 특정 음식과 함께 복용하는 경우에는 발효 공진단의 효능이 더욱 향상될 수 있다. On the other hand, the effect of the fermentation vestibule can be further improved when it is taken together with a specific food.

Claims (2)

발효 녹용, 사향, 당귀 및 산수유 추출물을 유효성분으로 포함하는 발효 공진단 조성물.Fermented antler composition comprising fermented antler, musk, angelica, and corn oil as an active ingredient. 산수유, 녹용, 당귀, 사향을 천연꿀과 배합하는 단계,
배합한 원료를 발효하는 단계,
발효된 원료를 정량 검품하는 단계, 및
정량 검품된 원료를 약효 보호용 금박으로 포장하는 단계를 포함하는 발효 공진단의 제조방법.Combining natural oil with corn oil, antler, angelica and musk,
Fermenting the blended raw material,
Quantitatively inspecting the fermented raw material, and
And packaging the quantitatively inspected raw material with gold foil for protecting the fermentation effect.
KR1020140147350A 2014-10-28 2014-10-28 Fermented gongjindan composition and fabricating method thereof KR20160049750A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020140147350A KR20160049750A (en) 2014-10-28 2014-10-28 Fermented gongjindan composition and fabricating method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020140147350A KR20160049750A (en) 2014-10-28 2014-10-28 Fermented gongjindan composition and fabricating method thereof

Publications (1)

Publication Number Publication Date
KR20160049750A true KR20160049750A (en) 2016-05-10

Family

ID=56020891

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020140147350A KR20160049750A (en) 2014-10-28 2014-10-28 Fermented gongjindan composition and fabricating method thereof

Country Status (1)

Country Link
KR (1) KR20160049750A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180059332A (en) 2016-11-25 2018-06-04 익수제약 주식회사 Gongjindan liquid composition and its preparing method
KR20180080532A (en) * 2017-01-04 2018-07-12 대전대학교 산학협력단 Liquefied gongjindan composition and manufacturing method thereof
KR102222753B1 (en) * 2020-10-30 2021-03-04 김성태 Manufacturing method of agarwood gongjindan with excellent absorption rate in the body
KR102238374B1 (en) 2020-09-08 2021-04-09 김담희 Manufacturing method of gongjindan
KR102238831B1 (en) 2020-07-21 2021-04-09 박종광 GONGJIINDAN composition containing OMAEYUK(dried fruit of Prunus mume) and its manufacturing method
KR102443883B1 (en) 2022-04-14 2022-09-19 주식회사 하이헴프씨 Resonant containing hemp seed solids and it's preparation method
WO2022220337A1 (en) * 2021-04-12 2022-10-20 김성태 Optimum aquilariae resinatum lignum pill formulating method capable of enhancing content of active ingredient
KR20230139234A (en) * 2022-03-25 2023-10-05 광동제약 주식회사 An apparatus for adhering gold leaf on the surface of pills
KR20230139228A (en) * 2022-03-25 2023-10-05 광동제약 주식회사 An apparatus for rolling gold leaf on the surface of pills

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180059332A (en) 2016-11-25 2018-06-04 익수제약 주식회사 Gongjindan liquid composition and its preparing method
KR20180080532A (en) * 2017-01-04 2018-07-12 대전대학교 산학협력단 Liquefied gongjindan composition and manufacturing method thereof
KR102238831B1 (en) 2020-07-21 2021-04-09 박종광 GONGJIINDAN composition containing OMAEYUK(dried fruit of Prunus mume) and its manufacturing method
KR102238374B1 (en) 2020-09-08 2021-04-09 김담희 Manufacturing method of gongjindan
KR102222753B1 (en) * 2020-10-30 2021-03-04 김성태 Manufacturing method of agarwood gongjindan with excellent absorption rate in the body
WO2022220337A1 (en) * 2021-04-12 2022-10-20 김성태 Optimum aquilariae resinatum lignum pill formulating method capable of enhancing content of active ingredient
KR20230139234A (en) * 2022-03-25 2023-10-05 광동제약 주식회사 An apparatus for adhering gold leaf on the surface of pills
KR20230139228A (en) * 2022-03-25 2023-10-05 광동제약 주식회사 An apparatus for rolling gold leaf on the surface of pills
KR102443883B1 (en) 2022-04-14 2022-09-19 주식회사 하이헴프씨 Resonant containing hemp seed solids and it's preparation method

Similar Documents

Publication Publication Date Title
KR20160049750A (en) Fermented gongjindan composition and fabricating method thereof
Sabaratnam et al. Neuronal health–can culinary and medicinal mushrooms help?
US20200352206A1 (en) Composition and method for mushroom mycelial compound and botanical mixture
CN108367033A (en) The method and composition of depressive symptom is treated or prevented using bifidobacterium longum
KR101177245B1 (en) Dietary supplement containing fermented rice bran of brown rice and manufacturing method thereof
KR20160049751A (en) Gongjindan composition comprising bear gall and fabricating method thereof
CN102266058B (en) Yam and hawthorn lipid-lowering nutritional tablets
CN102178934B (en) Preparation for increasing bone mineral density, preventing osteoarthrosis and enhancing immunity
CN1480066A (en) Phycomycetes food for improving physical ability of athletes and its preparation method
KR101687982B1 (en) Composition for improving sexual functionality having effects of increasing of the number of sperm and protection of environmental hormone and manufacturing method thereof
CN102488278A (en) Composite fungus nutrient solution with bifunctional health care effect
CN109170086A (en) A kind of chlorella pyrenoidosa pressed candy and preparation method thereof with immune enhancing function
CN105661515B (en) A kind of ferment lozenge for preventing three high diseases and preparation method thereof
KR102139732B1 (en) Composition for improving immune activity containing lactobacillus
CN107073024A (en) Containing the pharmaceutical compositions for being used to preventing or treating Gleevec drug resistance leukaemia of GF1 or Rg3 as active ingredient
KR101974886B1 (en) Gongjindan for memory enhancement and learning capabilities and manufacturing method thereof
KR101220131B1 (en) An enzymatically treated brown rice and process for preparing thereof
CN105394515A (en) Pleurotus sajor-caju-cattail solid-state fermented functional drink and preparation method
KR20130051678A (en) Composition comprising the extracts of hericium erinaceus for the enhancement of memory or the improvement of learning
CN1189102C (en) Lophatherum herb beverage
Hobbs Christopher Hobbs's Medicinal Mushrooms: The Essential Guide: Boost Immunity, Improve Memory, Fight Cancer, Stop Infection, and Expand Your Consciousness
US7556832B2 (en) Process and formula for treating irritable bowel syndrome
CN1102394C (en) Health care product containing lactein and its preparing method
CN103519305B (en) Sweet corn low-sugar composite type beverage and preparation method thereof
CN1946414A (en) Improving profiles of lipid proteins and inhibiting HMG-CoA reductase

Legal Events

Date Code Title Description
WITN Withdrawal due to no request for examination