KR20160026549A - Cosmetic composition for the alleviation of pruritic disease containing seaweed calcium mineral water - Google Patents

Abstract

The present invention relates to a cosmetic composition of seaweed calcium mineral water for alleviating pruritus. Specifically, the seaweed calcium mineral water of the present invention can be used as a cosmetic composition for alleviating pruritus by not having toxicity for cells, inhibiting activity of PAR-2 which is an itchiness inducing factor, and has excellent skin moisturizing function.

Description

Technical Field [0001] The present invention relates to a cosmetic composition for alleviating skin pruritus containing seaweed calcium mineral water,

The present invention relates to a cosmetic composition for alleviating skin itching which contains seaweed calcium mineral water as an active ingredient.

Itching (pruritus) is a prominent symptom of many skin disorders and is a relatively common symptom that can occur even in the presence of systemic disease throughout the body, which can be defined as an unpleasant sensation that causes an impulse to scratch or rub the skin.

Systemic itching can be caused by skin irritation, irritation by certain bath products or detergents, or allergic reactions to certain medications. It may also be a symptom of a disease such as atopic dermatitis, herpes dermatitis, acne, insect bites, psoriasis, urticaria, contact dermatitis, psoriasis, eczema and chronic kidney failure.

Itching can also be the result of emotional stress, especially stress, anxiety, and fear, which can often be itchy and throat pruritic. Particularly, it is the most itching when I go to bed at night in the evening. The area around the eyelids, nostrils, ear hole, anus, genitalia and surrounding areas are the most sensitive areas for itching.

To treat and ameliorate itch, skin itching and systemic itch are all important to find and treat itch.

Usually, corticosteroids (steroids) are used frequently, and systemic or topical application treats itching caused by inflammation or pox. Cooling the skin with calamine lotion or 1% menthol lotion is also helpful. It also alleviates itching with 0.5% ~ 1% phenol lotion and local anesthetic Promoxine.

Capsaicin ointment consumes neuropeptides at the sensory nerve endings and is effective for some local chronic benign skin lesions. Phenothiazine-based antihistamines are commonly used as anti-idiotics, and in some cases, tricyclic antidepressants and opioid receptor antagonists are also used for itching, which is not responsive to treatment.

 However, corticosteroids have problems that cause serious adverse effects in prolonged or excessive use. For example, a full face, adrenocortical insufficiency, osteoporosis, worsening infectious disease, diabetes, menstrual disorder, headache, dizziness, muscle pain, edema, elevated blood pressure, increased IOP, acne, fatigue and weight gain may occur.

In addition, inhibition of fibroblast activity by steroids and lowered collagen production causes skin atrophy, which causes skin to become thin and function is weak. (S. Hammer et al., J. Cell. Biochem, 91, 840-851, 2004).

Antihistamine is a synthetic substance that blocks the histamine I receptor and temporarily alleviates allergic symptoms (fever, swelling, itching, sneezing, clear runny nose). However, antihistamines can also manifest various side effects, such as mouth dryness, improved eating, sleepiness, and lack of concentration.

Accordingly, there is a need to develop an itching relieving composition which can prevent serious side effects of therapeutic agents synthesized by an artificial method in terms of skin safety, and which can be supplied in the form of a harmless natural product even when applied to the skin for a long period of time.

Seaweed Calcium Mineral water is a source of seaweed, which is classified as red algae. It is an edible plant that grows in clean waters. It has a red pigment in addition to chlorophyll. It absorbs various nutrients and minerals, contains 95 ~ 99% of calcium in the stem, and it is harvested and processed into seaweed calcium. Calcium content of seaweed calcium is more than 34% and there is no fiber or phytic acid which interferes with calcium absorption. In addition to magnesium 2.4%, potassium 0.7%, sulfur 0.67%, phosphorus 0.08%, iron 915ppm, manganese 125ppm, zinc 26.1ppm, It contains several trace elements that contribute to activity. (Joy L Frestedt, Nutr J., 8-7, 2009)

The effect of calcium on skin is still unclear as to which signal is indicative of recovery after damage to the skin barrier, but it is associated with ionic changes in keratinocytes, particularly the role of calcium ions.

Normally, there is a calcium gradient in the epidermis, and the concentration of calcium ion is low in the basal layer and the anolyte layer, and increases with the upper layer, which is the highest in the outer granular layer. Damage of the skin barrier induces water loss from the upper part of the skin, and the water loss resulting from this leads to a change in calcium slope in the epidermis. This change in calcium gradient causes a homeostatic recovery in the skin, which in turn results in a quick recovery of the skin barrier function and subsequent normal calcium gradient. In other words, changes in calcium ion play an important role as a signal to start the process of recovery after skin barrier damage. (Skin barrier studies, 2010)

The seaweed calcium mineral water present in the present invention is prepared by dissolving seaweed calcium in EL mineral water, and as a result, it is characterized by mineral-rich water. The EL mineral water is obtained by treating seawater with demineralized water as an electrolysis apparatus (Electrolysis (EL)). The electrolytic apparatus for desalting seawater includes a monovalent cation selective exchange membrane and a monovalent anion selective exchange membrane, Na < + > and Cl < " > can be selectively removed.

The desalted EL mineral water contains various minerals such as magnesium, calcium, potassium, zinc, selenium, manganese, and vanadium, which is also useful as an excellent natural mineral raw material.

Therefore, the number of calcium carbonate mineral in the present invention includes natural minerals such as magnesium, calcium, potassium, and trace minerals such as silicon, selenium, germanium, and vanadium which are important for physiological activity. A synergistic effect can be expected. The natural moisturizing factor serves to contain water in the stratum corneum, and it consists of amino acid 40%, minerals 18.5%, and other components such as sugar and organic acid.

In addition, the seaweed calcium mineral water is known to be excellent in absorbing and retaining the skin since the water molecular aggregate is finer than general water. Rich water retention leads to skin elasticity enhancement, and strengthens skin barrier, activates skin physiological function.

Psoriasis and atopic dermatitis, which are the most serious conditions of itching, are not clear, but chronic skin dryness and skin barrier damage are the main symptoms. The lesion progresses.

Recent studies have shown that proteinase-activated receptor-2 (PAR-2) is activated in the abovementioned diseases and causes itching (Kato, T., Allergy. 64 : 1366-1374, 2009)

PAR-2 increases the inflammatory response and thus increases expression of various inflammatory substances such as tumor necrosis factor (TNF) -α, IL-6 and IL-10 (Tsujii, K , J Pharmacol Sci. 109: 388-395, 2009). In other words, PAR-2 activation induces skin inflammation, pigmentation, and tingling, so inhibiting it is expected to help improve atopic dermatitis.

In addition, PAR-2 inhibitors have been reported to clinically improve atopic dermatitis when used as a topical application in clinical practice (Lee, YH, Kor J Dermatol. 48: 966-974, 2010) Is expected to ameliorate or treat the itch of atopic dermatitis.

Therefore, in order to alleviate itching caused by skin dryness or skin condition, there is a method of inhibiting the activation of PAR-2 and, more importantly, restoring the calcium slope by supplying calcium to the lesion site and providing the minerals having excellent moisturizing power, It becomes rigid and flexible, and the function as a defensive wall can be restored.

Accordingly, the inventors of the present invention have made efforts to develop a composition for alleviating skin itching. As a result, it has been confirmed that the number of seaweed calcium minerals inhibits the activity of PAR-2 and improves water retention, The present invention has been completed.

An object of the present invention is to provide a composition for alleviating skin itching, which contains seaweed calcium mineral water as an active ingredient, and cosmetic compositions for improvement.

In order to accomplish the above object, the present invention provides a composition for alleviating itching which contains seaweed calcium mineral water as an effective ingredient.

In addition, the present invention provides a cosmetic for alleviating itching, which contains seaweed calcium mineral water as an active ingredient.

The number of seaweed calcium mineral of the present invention has an effect of inhibiting the activity of PAR-2 and improving the retention of water, and thus can be usefully used as an effective ingredient of a composition for alleviating itch.

FIG. 1 is a view showing a method of producing a seaweed calcium mineral water.
2 is a graph showing cell viability according to the concentration of seaweed calcium mineral water through MTT analysis.
FIG. 3 is a graph showing the inhibitory activity of PAR-2 by treating seaweed calcium mineral water in HaCaT cells.
Fig. 4 is a graph showing the results of the moisturizing effect of seaweed calcium mineral water.

Hereinafter, the present invention will be described in detail.

The present invention provides a composition for relieving itching which contains seaweed calcium mineral water as an effective ingredient.

The number of seaweed calcium mineral is preferably, but not limited to, produced by a manufacturing method comprising the steps of:

1) electrolyzing seawater to obtain EL mineral water (demineralized water);

2) dissolving seaweed calcium in EL mineral water;

3) filtering the seaweed calcium mineral water of step 2)

In the above method, the seaweed calcium of step 2) may be used without limitation such as cultivated or commercially available.

The seawater is preferably used in general seawater, but it can be used without limitation such as deep seawater and lava seawater.

Electrodialysis equipment for seawater desalination is composed of a ferrite electrode, a platinum-plated titanium electrode, a titanium electrode fired electrode, and the like as an anode. Examples of the cathode include a stainless electrode, a platinum-plated titanium electrode, A titanium-plated sintered electrode, or the like, or an electrolytic apparatus of the present invention, which is composed of an ion exchange membrane, is preferable.

The content of the seaweed calcium contained in the seaweed calcium mineral water is preferably in the range of 1.0 to 20% by weight based on the total weight.

The seaweed calcium mineral water of the present invention can be obtained through the above process.

The present invention provides a cosmetic composition for alleviating skin itching comprising the alga calcium mineral water obtained by the above production method as an active ingredient.

When the cosmetic preparation is prepared using the seaweed calcium mineral water according to the present invention, it contains 0.05 to 50% by weight, preferably 0.5 to 25% by weight based on the total weight of the cosmetic.

The cosmetic composition characterized by containing the above-mentioned seaweed calcium mineral water,

Depending on the method, it can be formulated into a mist spray, a skin lotion, a cream, an essence, a lip balm, a cleanser, a shampoo, etc., but is not limited thereto.

The cosmetic composition of the present invention is an essential component of a calcium alcaline mineral, and may be blended with other ingredients usually added to cosmetics as necessary.

The components that can be blended include an oily component, an aqueous component, a surfactant, a flavor, an active ingredient, an ultraviolet shielding component, a film forming agent, an increasing agent, a moisturizer and a coloring material.

Examples of the oily components include vegetable oils (wheat germ oil, almond oil, olive oil, avocado oil, jojoba oil, jojoba oil ester, macadamia oil, evening primrose oil, rosehip oil, apricot seed oil, sunflower oil, grapeseed oil, Grapefruit seed oil, etc.), animal oils (mink oil, emu oil, etc.), waxes (vegetable waxes: carnauba wax, candelilla wax, shea butter, animal waxes: beeswax, lanolin, (Liquid paraffin, paraffin, vaseline, scaly, ozokerite, microcrystalline wax, etc.) such as oil (dimethylsilicone, dimethicone, dimethylpolysiloxane, cyclomethicone, vinyl dimethicone crosspolymer, cyclopentasiloxane and the like) ), Higher fatty acids (lauric acid, myristic acid, palmitic acid and stearic acid), higher alcohols (cetyl alcohol, stearyl alcohol, cetostearyl alcohol, Etc.), esters (isopropyl myristate, cetyl octanoate, cetyl ethylhexonate, octyldodecyl myristate, etc.) and the like can be used.

Examples of the aqueous component include water, ethanol, a moisturizing agent (polyol, natural moisturizing factor, polymer moisturizer, etc.), and specific moisturizers include polyols (trehalose, betaine, glycerin, propylene glycol, 1-3-butylene glycol (Amino acid, PCA, urea, lactate, glucosamine, citrate, sugar, peptide, etc.), polymeric moisturizing agents (hyaluronic acid, conidialium sulfate, collagen etc.) Can be used.

Examples of the surfactant include anionic surfactants such as sodium lauryl sulfate, sodium lauroyl glutamate, sodium cocoyl glutamate, disodium cocoamphodiacetate, sodium cocoamphoacetate, cocamidosulfate, and the like, which are used for emulsification, solubilization, Cationic surfactants (benzalkonium chloride), amphoteric surfactants (cocoamphocarboxyl glycinate, cocamidopropyl betaine, sodium lauryl glucosecarboxylate), nonionic surfactants (PEG- 60 hydroganed castor oil, decyl glucoside, sorbitol rebate, cetyl olivate, lauryl glucoside, cetearyl glucoside, polyoxyethylene type, poly, etc.).

As the fragrance, natural fragrance, synthetic fragrance, combination fragrance and the like can be used.

The active ingredient may be selected from the group consisting of ginseng extract, ginkgo leaf extract, chamomile extract, rosemary extract, Karen dulcis extract, collagen, placenta extract, cilium extract, propolis, royal jelly extract, licorice extract, green tea extract, aloe vera extract, Vitamin A and its derivatives, pyridoxine, di-panthenol, vitamin C, vitamin E, biotin, niacinamide, etc. as vitamins and other active ingredients such as L-carnitine, Citric acid, salicylic acid, clay (nano clay, etc.), alginic acid, ultraviolet ray blocking agent, and the like can be used.

Examples of the ultraviolet shielding component include TiO2, TiO2-capsules, TiO2 colloid, TiO2-organic hybrid materials, ZnO, iron oxide, zirconium oxide, ceramic powder, metal oxide and organic or inorganic hybrid materials thereof, metal oxide nanoparticles, A benzoylmethane derivative, a camphor derivative, octylmethoxycinnamate, octyl salicylate, octocrylene, octyl salicylate, octyl salicylate, octyl salicylate, Organic pigments, white pigments, coloring pigments, extender pigments, ultraviolet absorbing organic materials, ultraviolet absorbing polymers, organic pigments, organic pigments, coloring pigments, extender pigments, Ultraviolet ray absorbing inorganic material, ultraviolet scattering inorganic material, ultraviolet ray preventing organic / inorganic hybrid material and the like can be used.

Examples of the film-forming agent include polyvinyl alcohol, polyvinylpyrrolidone, methoxyethylene, maleic anhydride copolymer, amphoteric methacrylic ester copolymer, cationized cellulose, poly (methylenediphenyl chloride), polyacrylic acid ester copolymer, There may be used polyvinyl acetate, nitrocellulose, polymeric silicone, silicone resin, dimethylsilicone, dimethicone, dimethylpolysiloxane, cyclomethicone, vinyl dimethicone crosspolymer, cyclopentasiloxane and the like. Specific examples of the sequestering agent include ethylenediamine 4 Sodium acetic acid (EDTA), phosphoric acid, citric acid, ascorbic acid, succinic acid, gluconic acid, sodium polyphosphate, sodium metaphosphate, disodium EDTA, and sodium citrate.

Examples of the above-mentioned thickener include vegetable materials (such as guar gum, locust bean gum, quince seed, carrageenan, garnet, gum arabic, kragakan gum, pectin, mannan, starch, etc.), microorganisms (xanthan gum, dextran, Cellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, Methylhydroxypropylcellulose, etc.), starch based (soluble starch, carboxymethyl starch, methyl starch and the like), alginic acid-based propylene glycol esters of alginic acid 9 and alginic acid salts), synthetic polymers such as polyvinyl alcohol, polyvinylpyrrolidone Polyvinyl methyl ether, carboxyvinyl polymer, polyacrylic oxygen, etc.), inorganic materials such as bentonite, laponite, fine powder silicon oxide, DE alumina and the like may be used and the like, polyethylene oxide, ethylene oxide, propylene block copolymer can be used side by other.

Examples of the moisturizing agent include polyols, natural moisturizing agents, polymeric moisturizers, and the like. Specific moisturizers include polyols (trehalose, betaine, glycerin, propylene glycol, 1-3-butylene glycol, caprylyl glycol, polyethylene glycol, 1,2-hexanediol), natural moisturizing factors (amino acids, PCA, urea, lactate, glucosamine, citrate, sugar, peptide and the like) and polymeric moisturizing agents (hyaluronic acid, conidialiumsulfuric acid, collagen etc.) .

Further, as the coloring material, there may be mentioned a dye (azo dye, quinoline dye, triphenyl methane dye, anthraquinone dye, tar pigment, FD & C Yellow No 6, FD & C Yellow No 4), rake (aluminum, calcium, magnesium (D & C RED No30, etc.), white pigments (titanium dioxide, zinc oxide, etc.), colored pigments (such as iron oxide and iron oxide) , Natural colorants (cochineal, beta-carotene, anthocyanin, etc.), pearl-like pigments (such as mica, talc, kaolin, calcium carbonate, magnesium carbonate, anhydrous silicic acid and sericite) Mica titanium, etc.), polymer pigments (nylon powder, polymethylketaacrylate, etc.), functional pigments (boroniteite, synthetic mica, etc.) and the like.

In addition, any of the above components may be compounded within a range that does not impair the objects and effects of the present invention, but is preferably incorporated in an amount of 0.5 to 25% by weight based on the total weight of the composition.

The cosmetic of the present invention may take the form of a solution, an emulsion, a viscous mixture or the like.

Examples of the shape of the cosmetic material are not particularly limited, and examples thereof include an emulsion, a cream, a lotion, a pack, a foundation, a lotion, a serum, a hair cosmetic, and the like.

In a specific embodiment of the present invention, the present inventors measured the toxicity to cells through MTT analysis in human fibroblasts (ATCC, CRL-T3-L1) using seaweed calcium mineral water, and found that the highest concentration of seaweed calcium minerals (200 < RTI ID = 0.0 > pg / ml) < / RTI > Further, as a result of investigating the effect of PAR-2 inhibitory activity on the number of seaweed calcium mineral water, it was confirmed that the amount of PAR-2 was reduced (see FIG. 3) and the water retention was also excellent (see FIG. 4).

Therefore, the seaweed calcium mineral water has no toxicity to cells and is excellent in the inhibition of the activity of PAR-2, which is an itching factor, and the effect of water retention, and thus can be usefully used as a cosmetic composition for relieving itching.

Hereinafter, the present invention will be described in detail with reference to Examples and Experimental Examples.

It should be noted, however, that the following examples and experimental examples are illustrative of the present invention, and the present invention is not limited to the following examples and experimental examples.

Example 1: Preparation of seaweed calcium mineral water

20 kg of seawater was taken from seawater in the Shinan County fortification area of Chonnam Province and added to each of the feed tanks of the anode and the cathode of the electrolysis apparatus (ASTOM CO.LTD, Japan). After a current of 0.1 to 3.0 A was passed for 60 minutes, The solution obtained from the cathode side was collected and 18 kg of EL mineral water was obtained. 0.15 kg of seaweed calcium was dissolved in 9.85 kg of the obtained EL minerals to prepare 10 kg of seaweed calcium mineral water, which was then filtered with a microfilter (0.45 μm, ADVANTEC).

<Experimental Example 1> Confirmation of cell survival rate effect

The cell survival rate effect on the number of seaweed calcium minerals of the present invention was measured as follows.

Human keratocytes HaCaT cells, in which skin cells were made into cell lines, were inoculated into 24-well culture plates at a concentration of 1 x 10 &lt; 5 &gt; cells / ml. DMEM (Dubelco'S Modified Eagle Medium, BRL, USA) containing 10% bovine serum was used. After 24 hours of inoculation, the medium was replaced with 1 ml of DMEM containing 2% bovine serum, Seaweed calcium mineral water was added at 10 μl per concentration and cultured in 37, 5% CO2 incubator for 2 days. After the incubation, 1 ml of a supernatant solution of 2.5 mg / ml of a yellow tetrazolium salt (MTT) was added to each well. After 4 hours, the yellow tetrazolium salt solution was removed and 1 ml of dimethylsulfoxide (DMSO) , And the absorbance was measured at 540 nm after dissolving for 10 minutes. In addition, as a negative control, the solvent of DMSO water was subjected to the same method as above, and the cell proliferation effect was compared from the difference in relative absorbance.

As a result of the above experiment, as shown in Fig. 2, the number of seaweed calcium mineral obtained in Example 1 was excellent in cell viability at all concentrations.

<Experimental Example 2> Inhibitory effect on PAR-2 production

The inhibitory effect of PAR-2 on the number of seaweed calcium minerals of the present invention was measured as follows.

1) HaCaT cell culture and treatment of seaweed calcium mineral water

HaCaT cells were cultured in RPMI media containing 10% FBS, 2 mM L-glutamine, 100 IU / ml penicillin and 100 μg / ml streptomycin / penicilin. Since HaCaT cells require immobilization of cells on the bottom of the plate, 1 x 106 cells were transferred to a 12-well plate coated with Matrigel Basement Membrane Matrix (BD, Franklin Lakes, NJ) for cell immobilization. After 2 days of transfer to a 12-well plate, the cells were replaced with FBS-free RPMI supplemented with 0.2% (w / v) BSA, and the house dust mite extract and seaweed calcium mineral water were added as a stimulant and cultured for 8 hours. Immediately thereafter, Krebs-Ringer bicarbonate (KRB) buffer (115 mM NaCl, 4.7 mM KCl, 1.2 mM MgSO4, 1.28 mM CaCl2, 1.2 mM KH2PO4, 25 mM HEPES, 8.4% NaHCO3, (wt / vol), 1 mg / mL BSA, pH 7.2). After incubation for 2 hours, the KRB solution was removed and the cells were washed with PBS to extract total RNA.

2) Expression of mRNA in cell

Total RNA was isolated from HaCaT cells by Trizol reagent (Gibco-BRL, Rockville, Md.) And precipitated with isopropyl alcohol. CDNA was prepared by adding oligo dT primer, superscript III reverse transcriptase, and Taq DNA polymerase to the separated total RNA. Gene expression was measured by real time PCR (BioRad, Richmond, Calif.) Using a real-time gene amplifier (BioRad, Richmond, Calif.) By mixing the prepared cDNA with a primer of PAR-2 gene. Real-time PCR was performed at 94 ° C for 15 seconds, at 60 ° C for 15 seconds, and at 72 ° C for 33 seconds for 40 cycles. The specific reaction of the amplification product was confirmed by melting point. The glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as the housekeeping gene. The expression level of PAR-2 gene was calculated based on this gene as compared with the control group. The primers for each gene are shown below.

PAR-2 forward 5'-GAAGCCTTATTGGTAAGGTTG-3 ',

reverse 5'-CAGAGAGGAGGTCAGCCAAG;

GAPDH forward 5'-CTCCACTCACGGCAAATTCAAC-3 ';

reverse 5'-ACTCCACGACATACTCAGCACC-3 '

As a result of the above experiment, PAR-2 expression was effectively inhibited at 200 μg / mL of the number of seaweed calcium minerals obtained in Example 1 (FIG. 3)

<Experimental Example 3> Measurement of skin moisturizing ability of calcium carbonate mineral water

The skin moisturizing effect of the seaweed calcium mineral water of the present invention was measured and purified water was used as a control.

The moisture content of the skin was measured using a skin moisture meter (Comeometer CM 825), which measures skin moisture content by skin capacitance measurement. From the room 30 minutes before the start of the test, the calcium carbonate mineral water obtained in Example 1 was uniformly applied to the upper bosom in a room of constant temperature and humidity (20 to 22 ° C, relative humidity 40 to 60%), As a control, skin moisture content was measured immediately before application and immediately after application. After 10, 30, 60 and 120 minutes, skin moisture content was measured. The measured capacitance values were converted to arbitrary capacitance units (AU) between 0 and 120.

As a result, as shown in FIG. 4, it was confirmed that the number of seaweed calcium mineral obtained in Example 1 was superior to that of purified water used as a control.

The preparation examples of the cosmetic composition containing the seaweed calcium mineral water of the present invention will be described, but the present invention is not intended to be limited thereto but is specifically described.

Formulation Example 1. Skin number Raw material Content (% by weight) One  Seaweed Calcium Mineral Water 25.0 2  PEG-60 Hydrogenated Castor Oil 0.2 3  L-menthol 0.0 4  glycerin 1.5 5  Caprylyl glycol 0.2 6  Purified water Balance system 100.0

Formulation Example 2. Lotion number Raw material Content (% by weight) One  Seaweed Calcium Mineral Water 8.0 2  Trehalose 4.0 3  1,2hexanediol 1.5 4  L-arginine 0.7 5  glycerin 11.0 6  Xanthan gum 0.1 7  Licorice extract 0.1 8  Behenic acid 2.5 9  Shea Butter 2.0 10  Jojoba Ester 5.5 11  Cetyl oleate 2.5 12  Sorbitol rebate 1.5 13  Macadamia oil 2.0 14  Jojoba oil 0.8 15  Grapefruit Seed Seed Oil 0.1 16  Purified water Balance  system 100.0

Formulation Example 3. Cream number Raw material Content (% by weight) One  Seaweed Calcium Mineral Water 15.0 2  Cyclomethicone / Dimethicone / Vinyl Dimethicone Cross 4.6 3  Dimethylsilicone 4.0 4  Cyclopentasiloxane 5.0 5  Olive oil 0.2 6  Jojoba oil 0.2 7  Vitamin E 0.1 8  glycerin 5.0 9  Trehalose 1.0 10  Betaine 0.5 11  Allantoin 0.1 12  Niacinamide 0.1 13  Chamomile extract 0.1 14  Ginseng extract 0.1 15  Ginkgo biloba extract 0.1 16  Collagen 0.1 17  Sodium hyaluronate 0.2 18  1,2hexanediol 1.5 19  Aloe vera gel 3.0 20  Grapefruit Seed Seed Oil 0.1 21  Purified water Balance system 100.0

Formulation Example 4. Essence number Raw material Content (% by weight) One  Seaweed Calcium Mineral Water 1.0 2  Xanthan gum 0.4 3  Allantoin 0.1 4  1,2hexanediol 2.5 5  glycerin 8.0 6  Hyaluronic acid 2.0 7  Purified water Balance  system 100.0

Claims (2)

A cosmetic composition for alleviating itching skin containing calcium alcaline mineral water as an active ingredient
The composition according to claim 1, which is one or more formulations selected from the group consisting of a spray mist, a skin, a lotion, a toner, a cream, an essence, a pack, a soap, a cleansing foam, a cleansing lotion, a cleansing cream, a body lotion, a body cleanser and a shampoo Cosmetic composition

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