KR20150113762A - 황 작용기를 포함하는 4,5-다이하이드로-1h-피라졸-3-카복스이미드아마이드 유도체, 이의 제조방법 및 이를 포함하는 약학 조성물 - Google Patents

황 작용기를 포함하는 4,5-다이하이드로-1h-피라졸-3-카복스이미드아마이드 유도체, 이의 제조방법 및 이를 포함하는 약학 조성물 Download PDF

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Publication number
KR20150113762A
KR20150113762A KR1020140038258A KR20140038258A KR20150113762A KR 20150113762 A KR20150113762 A KR 20150113762A KR 1020140038258 A KR1020140038258 A KR 1020140038258A KR 20140038258 A KR20140038258 A KR 20140038258A KR 20150113762 A KR20150113762 A KR 20150113762A
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KR
South Korea
Prior art keywords
chlorophenyl
compound
dihydro
carboximidamide
pyrazole
Prior art date
Application number
KR1020140038258A
Other languages
English (en)
Korean (ko)
Inventor
홍동진
백종욱
오희숙
이문섭
하태희
서귀현
Original Assignee
한미약품 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한미약품 주식회사 filed Critical 한미약품 주식회사
Priority to KR1020140038258A priority Critical patent/KR20150113762A/ko
Priority to PCT/KR2015/002834 priority patent/WO2015152550A1/en
Priority to ARP150100918A priority patent/AR099870A1/es
Priority to TW104110276A priority patent/TW201623244A/zh
Publication of KR20150113762A publication Critical patent/KR20150113762A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020140038258A 2014-03-31 2014-03-31 황 작용기를 포함하는 4,5-다이하이드로-1h-피라졸-3-카복스이미드아마이드 유도체, 이의 제조방법 및 이를 포함하는 약학 조성물 KR20150113762A (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
KR1020140038258A KR20150113762A (ko) 2014-03-31 2014-03-31 황 작용기를 포함하는 4,5-다이하이드로-1h-피라졸-3-카복스이미드아마이드 유도체, 이의 제조방법 및 이를 포함하는 약학 조성물
PCT/KR2015/002834 WO2015152550A1 (en) 2014-03-31 2015-03-23 4,5-dihydro-1h-pyrazole-3-carboximidamide derivatives containing sulfur groups, method for preparing same, and pharmaceutical composition comprising same
ARP150100918A AR099870A1 (es) 2014-03-31 2015-03-27 Derivados de 4,5-dihidro-1h-pirazol-3-carboximidamida que contienen grupos azufre, método para prepararlos, y composición farmacéutica que los comprende
TW104110276A TW201623244A (zh) 2014-03-31 2015-03-30 包含硫基團之４，５－二氫－１ｈ－吡唑－３－甲脒衍生物、其製備方法以及包含其之藥學組成物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020140038258A KR20150113762A (ko) 2014-03-31 2014-03-31 황 작용기를 포함하는 4,5-다이하이드로-1h-피라졸-3-카복스이미드아마이드 유도체, 이의 제조방법 및 이를 포함하는 약학 조성물

Publications (1)

Publication Number Publication Date
KR20150113762A true KR20150113762A (ko) 2015-10-08

Family

ID=54240811

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020140038258A KR20150113762A (ko) 2014-03-31 2014-03-31 황 작용기를 포함하는 4,5-다이하이드로-1h-피라졸-3-카복스이미드아마이드 유도체, 이의 제조방법 및 이를 포함하는 약학 조성물

Country Status (4)

Country Link
KR (1) KR20150113762A (zh)
AR (1) AR099870A1 (zh)
TW (1) TW201623244A (zh)
WO (1) WO2015152550A1 (zh)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006045799A2 (en) * 2004-10-25 2006-05-04 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising cb1 cannabinoid receptor antagonists and potassium channel openers for the treatment of diabetes mellitus type i, obesity and related conditions
US7763607B2 (en) * 2006-04-27 2010-07-27 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators
US20070254863A1 (en) * 2006-04-27 2007-11-01 Jochen Antel Use of CBx cannabinoid receptor modulators as potassium channel modulators
TW200948798A (en) * 2008-04-23 2009-12-01 Solvay Pharm Bv (5R)-1, 5-diaryl-4, 5-dihydro-1H-pyrazole-3-carboxamidine derivatives having CB1-antagonistic activity

Also Published As

Publication number Publication date
WO2015152550A1 (en) 2015-10-08
AR099870A1 (es) 2016-08-24
TW201623244A (zh) 2016-07-01

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