KR20150093444A - Composition with the extract of Cudrania tricuspidata for the prevention of gastritis and gastric ulcer - Google Patents
Composition with the extract of Cudrania tricuspidata for the prevention of gastritis and gastric ulcer Download PDFInfo
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Abstract
Description
본 발명은 꾸지뽕나무 추출물을 함유하는 위염 및 위궤양 예방용 조성물에 관한 것으로, 구체적으로는 꾸지 뽕나무 잎의 알코올 추출물을 유효성분으로 함유하는 위염 및 위궤양 예방용 조성물에 관한 것이다.The present invention relates to a composition for the prevention of gastritis and gastric ulcer, which contains an extract of Alaska pollack. More specifically, the present invention relates to a composition for preventing gastritis and gastric ulcer comprising an alcohol extract of Leaf mulberry leaves as an active ingredient.
회식과 접대가 잦고, 여러 가지 요인에 의한 스트레스가 많은 현대인들에게 음주는 필수적인 것으로 자리 잡고 있으며, 그로 인하여 음주기회가 상당히 증가하고 있다.Drinking is becoming a necessity for modern people who frequent drinks and entertainments and are stressed by various factors, thereby drastically increasing opportunities for drinking.
한국 보건 사회 연구원 조사에 따르면 우리나라 20세 이상 성인의 경우 음주 빈도가 한 달에 약 8일이며, 남성의 경우 11일, 여성의 경우 약 4일 정도로 나타났고, 이때 만취 횟수는 주 1회 이상이 4.7% 정도, 1개월에 1 내지 3회가 약 13.2%로 나타났는데, 국민 건강의 측면에서 상당히 우려할 만한 수준이다.According to a survey by the Korea Institute of Health and Social Affairs, the frequency of drinking in Korea over 20 years old was about 8 days per month, 11 days for men and about 4 days for women. 4.7%, about 1 ~ 3 times a month, about 13.2%, which is very worrisome in terms of public health.
이와 같이 현대인들은 소화할 수 없을 정도의 알코올을 과량 섭취하는데, 이고 인한 부작용으로 갈증, 전신권태, 피로감, 기억상실, 복부팽만감, 구토, 설사 등의 숙취 현상으로 고생하는 경우가 많다. 또한, 과도한 알코올 섭취로 인해 간암, 간염, 위염, 위궤양 등의 발생률이 증가하고 있어, 이를 예방하기 위한 대책이 필요한 실정이다.In this way, modern people are consuming too much alcohol that can not be digested. As a side effect, many people suffer from thirst, general boredom, fatigue, amnesia, abdominal bloating, vomiting and diarrhea. In addition, the incidence of liver cancer, hepatitis, gastritis, gastric ulcer and the like is increasing due to excessive alcohol consumption, and measures are needed to prevent this.
한편, 위염(gastritis)은 위 점막에 생기는 염증성 질환을 통틀어 이르는 말이다. 위염은 급성의 경우 폭음, 폭식, 자극물 섭취, 병원균의 독소, 스트레스 등이 원인이 되고, 만성의 경우 불규칙한 식사, 약물 치료의 부작용, 유전적 요소 등이 원인이 된다. On the other hand, gastritis is an inflammatory disease that occurs throughout the gastric mucosa. Gastritis is caused by binge eating, binge eating, stimulant ingestion, toxins of pathogens, stress, and in chronic cases irregular eating, side effects of medication, and genetic factors.
또한, 위궤양(gastric ulcer)은 점막이 위산과 펩신에 잠겨 있는 부위의 손상을 의미한다. 이 부위는 정상적으로 점막 세포가 분비하는 뮤신에 의해 덮여있어, 뮤신 층 약화, 위산 과다분비, 아세트산 축적, 세균감염, 스트레스, 국소 혈액순환 장애, 세포손상 및 염증반응 등의 원인에 의해 위궤양이 유발된다.In addition, gastric ulcer refers to damage to the area where the mucosa is immersed in gastric acid and pepsin. This site is normally covered by mucin secreted by mucosal cells and causes gastric ulceration by causes such as mucin layer weakness, gastric acid secretion, accumulation of acetic acid, bacterial infection, stress, disturbance of blood circulation, cell damage and inflammatory reaction .
특히, 알코올로 인한 위염 및 위궤양은 가장 주의를 요하는데, 알코올은 위벽의 세포를 자극해 산 분비를 증가시키며, 과도한 알코올 섭취는 위점막의 부종을 발생시켜 출혈을 일으키고 염증세포들의 생성을 유도한다. 또한, 산화적 스트레스로 인한 괴사 혹은 세포사멸을 유도하여 위점막을 손상시키고, 위출혈이 나타나게 된다.In particular, gastritis and gastric ulceration due to alcohol require the most attention. Alcohol stimulates the cells of the gastric wall to increase acid secretion. Excessive alcohol consumption causes edema of the gastric mucosa, leading to bleeding and induction of inflammatory cells . In addition, it induces necrosis or cell death due to oxidative stress, damaging the gastric mucosa and causing gastrointestinal bleeding.
종래의 위염 및 위궤양의 치료제로는 과다 분비된 위산을 중화시키는 제산제(antacid), 산분비 억제목적의 히스타민 길항제(histamine antagonist), 프로톤펌프저해제(proton pump inhibitor), 콜린 억제제, 위내막의 내성을 증가시키고 회복을 돕는 위점막보호제 등이 있다. 다만, 이와 같은 치료제들은 합성 의약품으로 식욕감퇴, 무력감, 알레르기 등의 부작용이 발생하는 문제점이 있었다.Conventional treatments for gastritis and gastric ulcers include antacids that neutralize excess secreted acid, histamine antagonists to inhibit acid secretion, proton pump inhibitors, cholinergic inhibitors, and resistance to gastric lining And gastric mucosal protective agents that help increase recovery. However, such therapeutic agents are synthetic drugs and have side effects such as loss of appetite, weakness, and allergy.
이에, 대한민국 공개특허 제10-2009-0046425호(천마 추출물을 함유하는 위염 또는 위궤양의 예방 또는 치료용 조성물), 대한민국 등록특허 제10-1091025호(복분자 추출물을 함유하는 비스테로이드성 항염증제에 의해 유발된 위염 및 위궤양 예방 및 치료용 조성물), 대한민국 공개특허 제10-2012-0051904호(옻나무 추출물을 포함하는 위염 및 위궤양 치료제 조성물), 대한민국 등록특허 제10-1204981호(고로쇠 수액을 함유하는 위염 및 위궤양의 예방 및 치료용 조성물) 등 위염 및 위궤양의 예방 및 치료능이 있는 천연 추출물에 대한 관심이 높아지고 있다. Accordingly, Korean Patent Publication No. 10-2009-0046425 (composition for preventing or treating gastritis or gastric ulcer containing Ganoderma extract), Korean Patent No. 10-1091025 (induced by non-steroidal anti-inflammatory drug containing bokbunja extract Korean Patent Laid-Open Publication No. 10-2012-0051904 (composition for treating gastritis and gastric ulcer including Rhus verniciflua extract), Korean Patent No. 10-1204981 (composition for prevention and treatment of gastritis and gastric ulcer comprising Gonorrhea sap) There is a growing interest in natural extracts capable of preventing and treating gastritis and gastric ulcer, such as a composition for prevention and treatment of gastric ulcer.
한편, 꾸지뽕나무(Cudrania tricuspidata)는 뽕나무과 꾸지뽕나무속에 속하는 갈잎작은키 나무로, 우리나라 황해도 이남 중남부의 산기슭이나 들판에서 자란다. 꾸지뽕나무는 일반 뽕나무와 달리 긴 가시가 달려있고, 잎의 가장자리가 밋밋하며, 잎을 자르면 우유같은 흰액이 나오며, 열매에서도 같은 액이 나오는 것이 특징이다. 꾸지뽕나무는 플라노이드, 가바, 루틴, 아스파라긴산등 생리활성 물질을 함유하고 있으며, 항암, 진통, 항균, 어혈제거, 당뇨, 고혈압, 뇌출혈, 생리통, 냉증 완화, 아토피, 소염 등의 효능이 있다고 알려져 있다.On the other hand, Cudrania tricuspidata is a small leafy tree belonging to the mulberry and cicada trees. It grows in the foothills of the southern part of South Hwanghae province. Unlike ordinary mulberry trees, the culm trees have long thorns. The edges of the leaves are flat. When the leaves are cut, the white juice comes out like milk. It has been known that cucurbitan has the effects of anticancer, analgesic, antibacterial, antihypertensive, diabetic, hypertension, intracerebral hemorrhage, menstrual cramps, hypothermia, atopy, and inflammation as well as physiologically active substances such as plonoids, .
종래에 꾸지뽕나무를 이용한 기술로는 대한민국 등록특허 제10-1139032호(꾸지뽕 식초), 대한민국 등록특허 제10-1102172호(꾸지뽕 엿), 대한민국 등록특허 제10-1328668호(비만억제 활성과 혈당강하 효능이 있는 꾸지뽕 조성물), 대한민국 공개특허 제10-2013-0103989호(꾸지뽕을 함유하는 항산화 및 당뇨병 예방용 조성물) 등으로 다양한 기술이 있다. 하지만, 아직까지 꾸찌뽕나무의 위염 및 위궤양의 예방 효과에 대한 기술은 전무한 실정이다.
Conventional techniques using cucumber wood include Korean Patent No. 10-1139032 (Cucumber Pine Vinegar), Korean Patent No. 10-1102172 (Cucumber Paste), Korean Patent No. 10-1328668 (obesity inhibitory activity and hypoglycemic activity And Korean Patent Laid-Open No. 10-2013-0103989 (antioxidant and anti-diabetic composition containing ciprofloxacin). However, there is no description about the preventive effect of gastric ulcer and gastric ulcer on the mulberry tree.
본 발명은 꾸지뽕나무 잎의 알코올 추출물을 유효성분으로 함유하는 위염 및 위궤양 예방용 조성물을 제공하고자 한다.
The present invention provides a composition for the prevention of gastritis and gastric ulcer, which comprises an alcoholic extract of Lilium japonica as an active ingredient.
상기 목적을 달성하고자 본 발명은 꾸지뽕나무 잎의 알코올 추출물을 유효성분으로 함유하는 위염 및 위궤양 예방용 조성물을 제공한다.In order to accomplish the above object, the present invention provides a composition for preventing gastritis and gastric ulcer comprising an alcohol extract of Lilium japonica as an active ingredient.
한편, 본 발명에 있어서, 상기 꾸지뽕나무 잎의 알코올 추출물은 바람직하게 10%(v/v) 알코올로 추출된 것이 좋다.Meanwhile, in the present invention, the alcohol extract of Cucurbitaceae leaves is preferably extracted with 10% (v / v) alcohol.
한편, 본 발명에 있어서, 상기 위염 및 위궤양은 바람직하게 알코올성인 것이 좋다.In the present invention, the gastritis and gastric ulcer are preferably alcoholic.
한편, 본 발명에 있어서, 상기 꾸지뽕나무는 시중에서 구할 수 있는 꾸지뽕나무를 이용할 수 있으나, 바람직하게 고성에서 자란 고성 꾸지뽕나무를 이용하는 것이 좋다. 고성은 산과 호수, 동해의 해풍, 금강산과 설악산의 높새바람이 어우러진 청정지역이며, 찬 기온과 강한 바람, 햇빛, 토양 등의 자연 환경의 영향으로 타지역의 꾸지뽕나무에 비해 플라노이드, 가바, 루틴, 아스파라긴산 등의 생리 활성 물질 함량이 높기 때문이다.Meanwhile, in the present invention, the above-mentioned cedarwood can be obtained from commercially available cedarwood, but it is preferable to use high-grade cedarwood which has been grown in the highland. Goseong is a clean area where mountains and lakes, sea breezes of the East Sea, Mt. Geumgang and Mt. Seoraks are combined with each other. Due to cold weather, strong wind, sunshine and soil, , And asparaginic acid.
한편, 본 발명의 위염 및 위궤양 예방용 조성물은 식품 조성물일 수 있다.Meanwhile, the composition for preventing gastritis and gastric ulcer of the present invention may be a food composition.
본 발명의 위염 및 위궤양 예방용 식품 조성물은 바람직하게 음료, 빵류, 스넥류, 젤리, 면류, 아이스크림류, 비타민 복합제 및 그 밖의 건강보조식품류 중 선택되는 어느 하나인 것인 것이 좋으나, 반드시 이에 한정되는 것은 아니다.The food composition for preventing gastritis and gastric ulcer of the present invention is preferably any one selected from drinks, breads, snacks, jellies, noodles, ice creams, vitamin complexes and other health supplement foods, no.
또한, 본 발명의 위염 및 위궤양 예방용 조성물 식품 제조 시에 통상적으로 첨가되는 성분을 포함하며, 예를 들어, 단백질, 탄수화물, 지방, 영양소 및 조미제를 포함한다. 예컨대, 드링크제로 제조되는 경우에는 유효성분으로서의 꾸지뽕나무 잎의 알코올 추출물 이외에 향미제 또는 천연 탄수화물을 추가 성분으로서 포함시킬 수 있다. 예를 들어, 천연 탄수화물은 모노사카라이드(예컨대, 글루코오스, 프록토오스 등); 디사카라이드(예컨대, 말토스,수크로오스 등); 올리고당; 폴리사카라이드(예컨대, 덱스트린, 시클로덱스트린 등); 및 당알코올(예컨대, 자일리톨, 소르비톨, 에리쓰리톨 등)을 포함한다. 향미제로서 천연 향미제(예컨대, 타우마틴, 스테비아 추출물 등) 및 합성 향미제(예컨대, 사카린, 아스파르탐 등)를 이용할 수 있다.
The compositions for preventing gastritis and gastric ulcers of the present invention include components that are conventionally added in the manufacture of foods, for example, proteins, carbohydrates, fats, nutrients, and seasonings. For example, in the case of a drink, a flavoring agent or a natural carbohydrate may be added as an additional ingredient in addition to the alcohol extract of the cucumber leaf as an active ingredient. For example, natural carbohydrates include monosaccharides (e.g., glucose, fructose, etc.); Disaccharides (e.g., maltose, sucrose, etc.); oligosaccharide; Polysaccharides (e.g., dextrin, cyclodextrin and the like); And sugar alcohols (e.g., xylitol, sorbitol, erythritol, etc.). Natural flavoring agents (e.g., tau martin, stevia extract, etc.) and synthetic flavoring agents (e.g., saccharin, aspartame, etc.) may be used as the flavoring agents.
본 발명에 의할 경우, 꾸지뽕나무 잎의 알코올 추출물을 유효성분으로 함유하여 우수한 위염 및 위궤양 예방 효과를 가지는 조성물을 제공할 수 있다.
According to the present invention, it is possible to provide a composition having an excellent gastritis and gastric ulcer prevention effect by containing an alcoholic extract of a cedar leaf as an active ingredient.
이하, 본 발명의 내용을 하기 실시예를 통해 더욱 상세히 설명하고자 한다. 다만, 본 발명의 권리범위가 하기 실시예에만 한정되는 것은 아니고, 그와 등가의 기술적 사상의 변형까지를 포함한다.
Hereinafter, the present invention will be described in more detail with reference to the following examples. However, the scope of the present invention is not limited to the following embodiments, and includes modifications of equivalent technical ideas.
실시예Example 1: One: 꾸지뽕나무Tree 잎의 알코올 추출물 제조 Alcohol extract production of leaves
꾸지뽕나무 잎 10 g을 세척한 후, 건조하였다. 건조된 꾸지뽕나무 잎을 분쇄하여 꾸지뽕나무 잎 분말을 제조하였다. 상기 꾸지뽕나무 잎 분말에 10%(v/v)의 알코올 수용액을 무게비로 5배 첨가한 뒤, 추출함으로써 꾸지뽕나무 잎의 알코올 추출물을 제조하였다.
10 g of cedarwood leaves were washed and then dried. Dried cucumber leaves were crushed to produce cucumber leaves. Alcoholic extracts of Cucurbitaceae leaves were prepared by adding 5% by weight of a 10% (v / v) aqueous alcohol solution to the cucurbit tree leaf powder.
실험예Experimental Example 1: One: 꾸지뽕나무Tree 잎의 알코올 추출물의 위궤양 예방 효과 확인 Identification of preventive effect of alcohol extract of leaves on gastric ulcer
본 실험예에서는 상기 실시예 1에서 제조한 꾸지뽕나무 잎의 알코올 추출물의 위염 및 위궤양 예방 효과를 확인하고자 하였다. In the present experimental example, the alcohol extract of Cucurbitaceae leaves prepared in Example 1 was tested for the prevention of gastritis and gastric ulcer.
7주령 쥐(rat)를 대조군(G1), 질병군(G2), 꾸지뽕나무 잎의 알코올 추출물 100 mg/kg 투여군(G3), 꾸지뽕나무 잎의 알코올 추출물 300 mg/kg 투여군(G4)으로 나누어 실험하였다. G1과 G2는 증류수, G3은 꾸지뽕나무 잎의 알코올 추출물 100 mg/kg, G4는 꾸지뽕나무 잎의 알코올 추출물 300 mg/kg을 7일 동안 10 ㎖/kg씩 1회 경구투여하였다. 7일째, 투여 3시간 후에 0.15M 염산(HCl) in 70% 에탄올을 1.5 ㎖씩 G2, G3, G4에 경구투여하여 위염 및 위궤양을 유발하였다. 질병 유발 1시간 후, 쥐를 개복하여 위 하단부를 결찰하고 봉합한 후, 4시간 후, 마취하에 사해한 뒤 위 조직을 적출하였다. Seven-week-old rats were divided into control group (G1), disease group (G2), alcohol extract of cucumber tree 100 mg / kg group (G3) and alcohol extract of cucumber tree leaf 300 mg / kg group . G1 and G2 were given 100 mg / kg of distilled water, G3 was 100 mg / kg of alfalfa leaf and 300 mg / kg of Alcohol Extract of Ganoderma lucidum were administered once at 10 ml / kg for 7 days. On the seventh day, 1.5 ml of 0.15 M hydrochloric acid (HCl) in 70% ethanol was orally administered to G2, G3 and G4 after 3 hours of administration to induce gastritis and gastric ulcer. After 1 hour of disease induction, rats were lavaged and ligated at the lower end of the stomach. After 4 hours, the stomach tissue was detached under anesthesia.
상기 적출된 위 조직을 절개하여 생리식염수에 세척하고 색감이 있는 고정판에 펼쳐 동일한 높이에서 사진 촬영하였다. 위 면적 중 에탄올/염산으로 인해 궤양이 유발된 부분을 육안으로 관찰하였다.The extracted stomach tissue was dissected, washed in physiological saline, and spread on a color fastener plate and photographed at the same height. The area of ulcer induced by ethanol / hydrochloric acid in the upper area was visually observed.
실험결과, 대조군 및 질병군에 비교하였을 때, 본 발명의 꾸지뽕나무 잎의 알코올 추출물을 투여한 군의 위는 에탄올/염산으로 유발된 궤양의 면적이 작음을 확인할 수 있었다. 또한, 투여량이 증가할수록 에탄올/염산으로 유발된 궤양의 면적이 더욱 작아짐을 알 수 있었다.As a result of the experiment, it was confirmed that the area of the ulcer induced by ethanol / hydrochloric acid in the stomach of the group treated with the alcohol extract of the present invention was lower than that of the control group and the diseased group. Also, as the dose was increased, the area of ulcer induced by ethanol / hydrochloric acid became smaller.
상기와 같은 결과로부터, 본 발명의 꾸지뽕나무 잎의 알코올 추출물은 알코올로 인한 위궤양을 우수하게 예방할 수 있음을 알 수 있었다. From the above results, it can be seen that the alcohol extract of Cucurbitaceae leaves of the present invention can excellently prevent gastric ulcer caused by alcohol.
Claims (3)
A composition for the prevention of gastritis and gastric ulcer, which comprises an alcohol extract of Cucurbitaceae leaves as an active ingredient.
상기 꾸지뽕나무 잎의 알코올 추출물은,
10%(v/v) 알코올로 추출된 것을 특징으로 하는 위염 및 위궤양 예방용 조성물.
The method according to claim 1,
The alcohol extract of the above-
The composition for preventing gastritis and gastric ulcer is characterized by being extracted with 10% (v / v) alcohol.
상기 위염 및 위궤양은,
알코올성인 것을 특징으로 하는 위염 및 위궤양 예방용 조성물.
The method according to claim 1,
The gastritis and gastric ulcer,
The composition for prevention of gastritis and gastric ulcer characterized by being alcoholic.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105435099A (en) * | 2015-12-11 | 2016-03-30 | 王平平 | Traditional Chinese medicine for treating superficial gastritis caused by damp heat in spleen and stomach |
| IT201800007105A1 (en) * | 2018-07-11 | 2020-01-11 | A DRUG TO TREAT GASTROELCOSIS AND ITS METHOD OF PREPARATION | |
| KR20200008736A (en) * | 2018-07-17 | 2020-01-29 | 주식회사한국야쿠르트 | Food composition for prevention and improvment of reflux esophagitis containing Cudrania tricuspidata extract as an effective factor |
| KR102079731B1 (en) * | 2019-08-30 | 2020-02-20 | 주식회사한국야쿠르트 | Composition for Preventing or Improving Functional Dyspepsia comprising Cudrania Tricuspidata Extract |
| KR102191363B1 (en) | 2020-04-29 | 2020-12-15 | 주식회사 한국야쿠르트 | Food composition containing extract of leaf of Cudrania Tricuspidata for prevention or improvement of Helicobacter pylori infection |
| KR20220081786A (en) | 2020-12-09 | 2022-06-16 | 전북대학교산학협력단 | Cudrania tricuspidata fruit-fermented vinegar with enhances antiobesity activity and producing method thereof |
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2014
- 2014-02-07 KR KR1020140014227A patent/KR20150093444A/en not_active Application Discontinuation
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105435099A (en) * | 2015-12-11 | 2016-03-30 | 王平平 | Traditional Chinese medicine for treating superficial gastritis caused by damp heat in spleen and stomach |
| IT201800007105A1 (en) * | 2018-07-11 | 2020-01-11 | A DRUG TO TREAT GASTROELCOSIS AND ITS METHOD OF PREPARATION | |
| KR20200008736A (en) * | 2018-07-17 | 2020-01-29 | 주식회사한국야쿠르트 | Food composition for prevention and improvment of reflux esophagitis containing Cudrania tricuspidata extract as an effective factor |
| KR102079731B1 (en) * | 2019-08-30 | 2020-02-20 | 주식회사한국야쿠르트 | Composition for Preventing or Improving Functional Dyspepsia comprising Cudrania Tricuspidata Extract |
| KR102191363B1 (en) | 2020-04-29 | 2020-12-15 | 주식회사 한국야쿠르트 | Food composition containing extract of leaf of Cudrania Tricuspidata for prevention or improvement of Helicobacter pylori infection |
| KR20220081786A (en) | 2020-12-09 | 2022-06-16 | 전북대학교산학협력단 | Cudrania tricuspidata fruit-fermented vinegar with enhances antiobesity activity and producing method thereof |
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