KR20150065948A - 오피오이드 및 프로스타글란딘 화합물의 약학 조합물 - Google Patents
오피오이드 및 프로스타글란딘 화합물의 약학 조합물 Download PDFInfo
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- KR20150065948A KR20150065948A KR1020157014224A KR20157014224A KR20150065948A KR 20150065948 A KR20150065948 A KR 20150065948A KR 1020157014224 A KR1020157014224 A KR 1020157014224A KR 20157014224 A KR20157014224 A KR 20157014224A KR 20150065948 A KR20150065948 A KR 20150065948A
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- KR
- South Korea
- Prior art keywords
- alkyl
- group
- compound
- hydroxy
- carbon atoms
- Prior art date
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- -1 prostaglandin compound Chemical class 0.000 title abstract description 63
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- 150000001875 compounds Chemical class 0.000 description 38
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 37
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- 150000003180 prostaglandins Chemical class 0.000 description 32
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- 229960002085 oxycodone Drugs 0.000 description 17
- 125000005843 halogen group Chemical group 0.000 description 16
- 125000001424 substituent group Chemical group 0.000 description 16
- 125000003118 aryl group Chemical group 0.000 description 15
- 150000002367 halogens Chemical class 0.000 description 15
- 229910052739 hydrogen Inorganic materials 0.000 description 15
- 239000001257 hydrogen Substances 0.000 description 15
- 125000004043 oxo group Chemical group O=* 0.000 description 15
- 150000001338 aliphatic hydrocarbons Chemical group 0.000 description 13
- 125000000623 heterocyclic group Chemical group 0.000 description 13
- 150000002431 hydrogen Chemical class 0.000 description 13
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- SZNYYWIUQFZLLT-UHFFFAOYSA-N 2-methyl-1-(2-methylpropoxy)propane Chemical compound CC(C)COCC(C)C SZNYYWIUQFZLLT-UHFFFAOYSA-N 0.000 description 2
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- 239000003963 antioxidant agent Substances 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/10—Laxatives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92955607P | 2007-07-03 | 2007-07-03 | |
| US60/929,556 | 2007-07-03 | ||
| PCT/JP2008/062435 WO2009005171A1 (en) | 2007-07-03 | 2008-07-03 | Pharmaceutical combination of opioid and prostaglandin compound |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020107002335A Division KR20100051802A (ko) | 2007-07-03 | 2008-07-03 | 오피오이드 및 프로스타글란딘 화합물의 약학 조합물 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167035985A Division KR20160150654A (ko) | 2007-07-03 | 2008-07-03 | 오피오이드 및 프로스타글란딘 화합물의 약학 조합물 |
Publications (1)
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| KR20150065948A true KR20150065948A (ko) | 2015-06-15 |
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|---|---|---|---|
| KR1020157014224A Ceased KR20150065948A (ko) | 2007-07-03 | 2008-07-03 | 오피오이드 및 프로스타글란딘 화합물의 약학 조합물 |
| KR1020167035985A Ceased KR20160150654A (ko) | 2007-07-03 | 2008-07-03 | 오피오이드 및 프로스타글란딘 화합물의 약학 조합물 |
| KR1020107002335A Ceased KR20100051802A (ko) | 2007-07-03 | 2008-07-03 | 오피오이드 및 프로스타글란딘 화합물의 약학 조합물 |
| KR1020187008035A Ceased KR20180032683A (ko) | 2007-07-03 | 2008-07-03 | 오피오이드 및 프로스타글란딘 화합물의 약학 조합물 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167035985A Ceased KR20160150654A (ko) | 2007-07-03 | 2008-07-03 | 오피오이드 및 프로스타글란딘 화합물의 약학 조합물 |
| KR1020107002335A Ceased KR20100051802A (ko) | 2007-07-03 | 2008-07-03 | 오피오이드 및 프로스타글란딘 화합물의 약학 조합물 |
| KR1020187008035A Ceased KR20180032683A (ko) | 2007-07-03 | 2008-07-03 | 오피오이드 및 프로스타글란딘 화합물의 약학 조합물 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20090030072A1 (enExample) |
| EP (1) | EP2170344A1 (enExample) |
| JP (3) | JP2010532315A (enExample) |
| KR (4) | KR20150065948A (enExample) |
| CN (1) | CN101827598B (enExample) |
| AU (1) | AU2008271981B2 (enExample) |
| BR (1) | BRPI0812832A2 (enExample) |
| CA (1) | CA2691102C (enExample) |
| IL (1) | IL202766A (enExample) |
| MX (1) | MX380998B (enExample) |
| NZ (1) | NZ582328A (enExample) |
| RU (1) | RU2488398C2 (enExample) |
| SG (1) | SG182235A1 (enExample) |
| WO (1) | WO2009005171A1 (enExample) |
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| ES2985035T3 (es) | 2008-09-15 | 2024-11-04 | Uniqure Biopharma B V | Mutante de polipéptido de factor IX, sus usos y su procedimiento de producción |
| WO2014159679A1 (en) | 2013-03-12 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for using lubiprostone to absorb fluid from the subretinal space |
| US20150057351A1 (en) * | 2013-08-22 | 2015-02-26 | Sucampo Ag | Method for treating neuropathic pain |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GB1581886A (en) * | 1977-05-26 | 1980-12-31 | May & Baker Ltd | Prostanol derivatives |
| US4569937A (en) * | 1985-02-11 | 1986-02-11 | E. I. Du Pont De Nemours And Company | Analgesic mixture of oxycodone and ibuprofen |
| US5428062A (en) * | 1987-01-28 | 1995-06-27 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti ulcers containing same |
| US5166174A (en) * | 1987-01-28 | 1992-11-24 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti-ulcers containing same |
| US5225439A (en) * | 1987-01-28 | 1993-07-06 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti ulcers containing same |
| US5317032A (en) * | 1987-10-02 | 1994-05-31 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo | Prostaglandin cathartic |
| KR100830061B1 (ko) | 1999-10-15 | 2008-05-16 | 수캄포 아게 | 이환식 화합물 조성물 및 이의 안정화 방법 |
| US6414016B1 (en) * | 2000-09-05 | 2002-07-02 | Sucampo, A.G. | Anti-constipation composition |
| TWI302100B (en) * | 2001-05-02 | 2008-10-21 | Sucampo Ag | Composition for treating drug-induced constipation |
| MXPA04002006A (es) * | 2001-08-31 | 2004-06-07 | Sucampo Ag | Analogos de prostagladina como abridor del canal de cloruro. |
| AR037524A1 (es) * | 2001-11-14 | 2004-11-17 | Sucampo Ag | Unidad de dosificacion que comprende un analogo de prostaglandina para el tratamiento de la constipacion |
| US7732487B2 (en) * | 2001-11-19 | 2010-06-08 | Sucampo Ag | Method for treating a disease or condition responsive to opening of C1C-2 channel |
| NZ536252A (en) | 2002-04-29 | 2007-06-29 | Alza Corp | Methods and dosage forms for controlled delivery of oxycodone |
| MXPA05006981A (es) * | 2002-12-27 | 2005-12-14 | Sucampo Ag | Derivados de prostaglandinas para el tratamiento de la molestia abdominal. |
| TWI387454B (zh) * | 2004-09-02 | 2013-03-01 | 蘇坎波公司 | 治療胃腸道疾病之方法及組成物 |
| JP2009529057A (ja) * | 2006-03-08 | 2009-08-13 | コートリア・コーポレーシヨン | Ｃｏｘ−関連胃損傷を予防するための非−選択的ｃｏｘ阻害剤との組み合わせ療法 |
| WO2008021394A2 (en) | 2006-08-15 | 2008-02-21 | Theraquest Biosciences, Llc | Pharmaceutical formulations of cannabinoids and method of use |
-
2008
- 2008-07-02 US US12/166,834 patent/US20090030072A1/en not_active Abandoned
- 2008-07-03 KR KR1020157014224A patent/KR20150065948A/ko not_active Ceased
- 2008-07-03 EP EP08778016A patent/EP2170344A1/en not_active Ceased
- 2008-07-03 KR KR1020167035985A patent/KR20160150654A/ko not_active Ceased
- 2008-07-03 BR BRPI0812832-4A2A patent/BRPI0812832A2/pt not_active Application Discontinuation
- 2008-07-03 SG SG2012047932A patent/SG182235A1/en unknown
- 2008-07-03 WO PCT/JP2008/062435 patent/WO2009005171A1/en not_active Ceased
- 2008-07-03 MX MX2015005871A patent/MX380998B/es unknown
- 2008-07-03 RU RU2010103506/15A patent/RU2488398C2/ru active
- 2008-07-03 CN CN2008800232764A patent/CN101827598B/zh active Active
- 2008-07-03 KR KR1020107002335A patent/KR20100051802A/ko not_active Ceased
- 2008-07-03 NZ NZ582328A patent/NZ582328A/xx unknown
- 2008-07-03 AU AU2008271981A patent/AU2008271981B2/en active Active
- 2008-07-03 JP JP2010500005A patent/JP2010532315A/ja not_active Withdrawn
- 2008-07-03 KR KR1020187008035A patent/KR20180032683A/ko not_active Ceased
- 2008-07-03 CA CA2691102A patent/CA2691102C/en active Active
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2009
- 2009-12-16 IL IL202766A patent/IL202766A/en active IP Right Grant
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2014
- 2014-08-22 JP JP2014169836A patent/JP2014237711A/ja active Pending
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2016
- 2016-12-15 JP JP2016243343A patent/JP2017048255A/ja active Pending
-
2017
- 2017-11-07 US US15/805,759 patent/US10561649B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2488398C2 (ru) | 2013-07-27 |
| MX380998B (es) | 2025-03-12 |
| US10561649B2 (en) | 2020-02-18 |
| IL202766A (en) | 2016-04-21 |
| NZ582328A (en) | 2012-08-31 |
| KR20180032683A (ko) | 2018-03-30 |
| JP2010532315A (ja) | 2010-10-07 |
| BRPI0812832A2 (pt) | 2014-12-09 |
| AU2008271981B2 (en) | 2013-08-29 |
| CA2691102A1 (en) | 2009-01-08 |
| EP2170344A1 (en) | 2010-04-07 |
| CA2691102C (en) | 2016-08-02 |
| JP2014237711A (ja) | 2014-12-18 |
| AU2008271981A1 (en) | 2009-01-08 |
| SG182235A1 (en) | 2012-07-30 |
| JP2017048255A (ja) | 2017-03-09 |
| IL202766A0 (en) | 2010-06-30 |
| KR20160150654A (ko) | 2016-12-30 |
| WO2009005171A1 (en) | 2009-01-08 |
| CN101827598B (zh) | 2013-01-02 |
| US20090030072A1 (en) | 2009-01-29 |
| CN101827598A (zh) | 2010-09-08 |
| KR20100051802A (ko) | 2010-05-18 |
| RU2010103506A (ru) | 2011-08-10 |
| US20180311233A1 (en) | 2018-11-01 |
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