JP2010532315A - オピオイドおよびプロスタグランジン化合物の医薬的組み合わせ - Google Patents

オピオイドおよびプロスタグランジン化合物の医薬的組み合わせ Download PDF

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Publication number
JP2010532315A
JP2010532315A JP2010500005A JP2010500005A JP2010532315A JP 2010532315 A JP2010532315 A JP 2010532315A JP 2010500005 A JP2010500005 A JP 2010500005A JP 2010500005 A JP2010500005 A JP 2010500005A JP 2010532315 A JP2010532315 A JP 2010532315A
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Prior art keywords
prostaglandin
compound
combination according
dihydro
keto
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JP2010500005A
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Japanese (ja)
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JP2010532315A5 (enExample
Inventor
隆司 上野
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Sucampo GmbH
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Sucampo GmbH
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Publication of JP2010532315A5 publication Critical patent/JP2010532315A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010500005A 2007-07-03 2008-07-03 オピオイドおよびプロスタグランジン化合物の医薬的組み合わせ Withdrawn JP2010532315A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92955607P 2007-07-03 2007-07-03
PCT/JP2008/062435 WO2009005171A1 (en) 2007-07-03 2008-07-03 Pharmaceutical combination of opioid and prostaglandin compound

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014169836A Division JP2014237711A (ja) 2007-07-03 2014-08-22 オピオイドおよびプロスタグランジン化合物の医薬的組み合わせ

Publications (2)

Publication Number Publication Date
JP2010532315A true JP2010532315A (ja) 2010-10-07
JP2010532315A5 JP2010532315A5 (enExample) 2011-08-18

Family

ID=39832186

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2010500005A Withdrawn JP2010532315A (ja) 2007-07-03 2008-07-03 オピオイドおよびプロスタグランジン化合物の医薬的組み合わせ
JP2014169836A Pending JP2014237711A (ja) 2007-07-03 2014-08-22 オピオイドおよびプロスタグランジン化合物の医薬的組み合わせ
JP2016243343A Pending JP2017048255A (ja) 2007-07-03 2016-12-15 オピオイドおよびプロスタグランジン化合物の医薬的組み合わせ

Family Applications After (2)

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JP2014169836A Pending JP2014237711A (ja) 2007-07-03 2014-08-22 オピオイドおよびプロスタグランジン化合物の医薬的組み合わせ
JP2016243343A Pending JP2017048255A (ja) 2007-07-03 2016-12-15 オピオイドおよびプロスタグランジン化合物の医薬的組み合わせ

Country Status (14)

Country Link
US (2) US20090030072A1 (enExample)
EP (1) EP2170344A1 (enExample)
JP (3) JP2010532315A (enExample)
KR (4) KR20150065948A (enExample)
CN (1) CN101827598B (enExample)
AU (1) AU2008271981B2 (enExample)
BR (1) BRPI0812832A2 (enExample)
CA (1) CA2691102C (enExample)
IL (1) IL202766A (enExample)
MX (1) MX380998B (enExample)
NZ (1) NZ582328A (enExample)
RU (1) RU2488398C2 (enExample)
SG (1) SG182235A1 (enExample)
WO (1) WO2009005171A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2985035T3 (es) 2008-09-15 2024-11-04 Uniqure Biopharma B V Mutante de polipéptido de factor IX, sus usos y su procedimiento de producción
WO2014159679A1 (en) 2013-03-12 2014-10-02 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods for using lubiprostone to absorb fluid from the subretinal space
US20150057351A1 (en) * 2013-08-22 2015-02-26 Sucampo Ag Method for treating neuropathic pain

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004527567A (ja) * 2001-05-02 2004-09-09 スキャンポ・アーゲー 15−ケト−プロスタグランジン類を含む薬物誘発性便秘処置用組成物
JP2005525405A (ja) * 2002-04-29 2005-08-25 アルザ・コーポレーシヨン オキシコドンを制御して補給する方法および剤型

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
GB1581886A (en) * 1977-05-26 1980-12-31 May & Baker Ltd Prostanol derivatives
US4569937A (en) * 1985-02-11 1986-02-11 E. I. Du Pont De Nemours And Company Analgesic mixture of oxycodone and ibuprofen
US5225439A (en) * 1987-01-28 1993-07-06 K.K. Ueno Seiyaku Oyo Kenkyujo Prostaglandins E and anti ulcers containing same
US5166174A (en) * 1987-01-28 1992-11-24 K.K. Ueno Seiyaku Oyo Kenkyujo Prostaglandins E and anti-ulcers containing same
US5380709A (en) * 1987-01-28 1995-01-10 K.K. Ueno Seiyaku Oyo Kenkyujo Prostaglandins E and anti ulcers containing same
US5317032A (en) * 1987-10-02 1994-05-31 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Prostaglandin cathartic
ATE402925T2 (de) 1999-10-15 2008-08-15 Sucampo Ag Neue zusammensetzung enthaltend eine bicyclische verbindung und ein glycerid
US6414016B1 (en) * 2000-09-05 2002-07-02 Sucampo, A.G. Anti-constipation composition
JP4786866B2 (ja) * 2001-08-31 2011-10-05 スキャンポ・アーゲー クロライドチャンネルオープナーとしてのプロスタグランジンアナログ
AR037524A1 (es) * 2001-11-14 2004-11-17 Sucampo Ag Unidad de dosificacion que comprende un analogo de prostaglandina para el tratamiento de la constipacion
US7732487B2 (en) * 2001-11-19 2010-06-08 Sucampo Ag Method for treating a disease or condition responsive to opening of C1C-2 channel
JP4889219B2 (ja) * 2002-12-27 2012-03-07 スキャンポ・アーゲー 腹部不快感の処置のためのプロスタグランジン誘導体
TWI387454B (zh) * 2004-09-02 2013-03-01 蘇坎波公司 治療胃腸道疾病之方法及組成物
CA2657606A1 (en) * 2006-03-08 2007-09-13 Cortria Corporation Combination therapy with non-selective cox inhibitors to prevent cox-related gastric injuries
WO2008021394A2 (en) 2006-08-15 2008-02-21 Theraquest Biosciences, Llc Pharmaceutical formulations of cannabinoids and method of use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004527567A (ja) * 2001-05-02 2004-09-09 スキャンポ・アーゲー 15−ケト−プロスタグランジン類を含む薬物誘発性便秘処置用組成物
JP2005525405A (ja) * 2002-04-29 2005-08-25 アルザ・コーポレーシヨン オキシコドンを制御して補給する方法および剤型

Non-Patent Citations (3)

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Title
JPN6013023271; UENO,R. et al: 'Effects of lubiprostone on morphine-induced constipation and analgesia' GASTROENTEROLOGY Vol.130, No.4, Suppl.2, 2006, p.A373-A374 *
JPN6013023273; RIVKIN,A. et al: 'Lubiprostone: Chloride channel activator for chronic constipation' CLINICAL THERAPEUTICS Vol.28, No.12, 200701, p.2008-2021 *
JPN6014016141; 高木敬次郎 他: 最新 基礎薬理学 初版, 19991025, p.141-147, 株式会社廣川書店 *

Also Published As

Publication number Publication date
CA2691102C (en) 2016-08-02
CN101827598B (zh) 2013-01-02
AU2008271981A1 (en) 2009-01-08
KR20160150654A (ko) 2016-12-30
RU2010103506A (ru) 2011-08-10
KR20150065948A (ko) 2015-06-15
EP2170344A1 (en) 2010-04-07
SG182235A1 (en) 2012-07-30
US20090030072A1 (en) 2009-01-29
JP2017048255A (ja) 2017-03-09
KR20100051802A (ko) 2010-05-18
NZ582328A (en) 2012-08-31
AU2008271981B2 (en) 2013-08-29
RU2488398C2 (ru) 2013-07-27
JP2014237711A (ja) 2014-12-18
CA2691102A1 (en) 2009-01-08
IL202766A (en) 2016-04-21
US10561649B2 (en) 2020-02-18
BRPI0812832A2 (pt) 2014-12-09
CN101827598A (zh) 2010-09-08
MX380998B (es) 2025-03-12
KR20180032683A (ko) 2018-03-30
US20180311233A1 (en) 2018-11-01
WO2009005171A1 (en) 2009-01-08
IL202766A0 (en) 2010-06-30

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