KR20150061635A - 아이오포르미놀의 중간체 화합물의 제조법 - Google Patents

아이오포르미놀의 중간체 화합물의 제조법 Download PDF

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Publication number
KR20150061635A
KR20150061635A KR1020157007427A KR20157007427A KR20150061635A KR 20150061635 A KR20150061635 A KR 20150061635A KR 1020157007427 A KR1020157007427 A KR 1020157007427A KR 20157007427 A KR20157007427 A KR 20157007427A KR 20150061635 A KR20150061635 A KR 20150061635A
Authority
KR
South Korea
Prior art keywords
compound
mixture
preparation
bis
compound mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020157007427A
Other languages
English (en)
Korean (ko)
Inventor
미켈 타닝
안드레아스 올슨
크리스티안 글뢰가르트
Original Assignee
지이 헬스케어 에이에스
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 지이 헬스케어 에이에스 filed Critical 지이 헬스케어 에이에스
Publication of KR20150061635A publication Critical patent/KR20150061635A/ko
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
KR1020157007427A 2012-09-27 2013-09-17 아이오포르미놀의 중간체 화합물의 제조법 Ceased KR20150061635A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20121102 2012-09-27
NO20121102 2012-09-27
PCT/US2013/060081 WO2014052091A1 (en) 2012-09-27 2013-09-17 Preparation of an intermediate compound of ioforminol

Publications (1)

Publication Number Publication Date
KR20150061635A true KR20150061635A (ko) 2015-06-04

Family

ID=49274871

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020157007427A Ceased KR20150061635A (ko) 2012-09-27 2013-09-17 아이오포르미놀의 중간체 화합물의 제조법

Country Status (12)

Country Link
US (1) US9884808B2 (https=)
EP (1) EP2900632B1 (https=)
JP (1) JP6431842B2 (https=)
KR (1) KR20150061635A (https=)
CN (2) CN110003038A (https=)
AU (1) AU2013323981B2 (https=)
BR (1) BR112015004591A2 (https=)
CA (1) CA2881852A1 (https=)
IN (1) IN2015DN01185A (https=)
MX (1) MX354604B (https=)
RU (1) RU2654461C2 (https=)
WO (1) WO2014052091A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX354604B (es) 2012-09-27 2018-03-07 Ge Healthcare As Preparacion de un compuesto intermediario de ioforminol.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE20733T1 (de) 1982-11-08 1986-08-15 Nyegaard & Co As Roentgenkontrastmittel.
AU6114396A (en) 1995-06-16 1997-01-15 Biophysica Foundation Formyl derivatives as nonionic contrast media
GB9624612D0 (en) 1996-11-26 1997-01-15 Nycomed Imaging As Process
GB9903109D0 (en) * 1999-02-11 1999-04-07 Nycomed Imaging As Process
NO20043305D0 (no) 2004-08-09 2004-08-09 Amersham Health As Preparation of lodixanol
NO20053687D0 (no) 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process.
BRPI0814811A2 (pt) 2007-07-12 2015-02-03 Ge Healthcare As Composto, agente, método, e composição de diagnóstico, uso de um composto, e, método de formação de imagem
US20110021822A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
MX354604B (es) 2012-09-27 2018-03-07 Ge Healthcare As Preparacion de un compuesto intermediario de ioforminol.
AU2013323982B2 (en) * 2012-09-27 2017-11-23 Ge Healthcare As Preparation of Ioforminol, an X-ray contrast agent

Also Published As

Publication number Publication date
JP2015532280A (ja) 2015-11-09
CN104661996A (zh) 2015-05-27
AU2013323981A1 (en) 2015-03-05
IN2015DN01185A (https=) 2015-06-26
MX2015003912A (es) 2015-08-05
US9884808B2 (en) 2018-02-06
RU2015107016A (ru) 2016-11-20
WO2014052091A1 (en) 2014-04-03
US20150246871A1 (en) 2015-09-03
CA2881852A1 (en) 2014-04-03
EP2900632A1 (en) 2015-08-05
CN110003038A (zh) 2019-07-12
JP6431842B2 (ja) 2018-11-28
AU2013323981B2 (en) 2017-09-14
MX354604B (es) 2018-03-07
EP2900632B1 (en) 2019-10-30
RU2654461C2 (ru) 2018-05-18
BR112015004591A2 (pt) 2017-07-04

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Patent event date: 20150324

Patent event code: PA01051R01D

Comment text: International Patent Application

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Patent event code: PA02012R01D

Patent event date: 20180817

Comment text: Request for Examination of Application

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Comment text: Notification of reason for refusal

Patent event date: 20200121

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20200616

Comment text: Decision to Refuse Application

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Patent event date: 20200121

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I