KR20150060969A - 저항성 가을 거염벌레 곤충의 관리를 위한 조합에서의 Cry1Ea의 사용 - Google Patents
저항성 가을 거염벌레 곤충의 관리를 위한 조합에서의 Cry1Ea의 사용 Download PDFInfo
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- KR20150060969A KR20150060969A KR1020157011245A KR20157011245A KR20150060969A KR 20150060969 A KR20150060969 A KR 20150060969A KR 1020157011245 A KR1020157011245 A KR 1020157011245A KR 20157011245 A KR20157011245 A KR 20157011245A KR 20150060969 A KR20150060969 A KR 20150060969A
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- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Catching Or Destruction (AREA)
- Peptides Or Proteins (AREA)
- Physiology (AREA)
- Botany (AREA)
- Developmental Biology & Embryology (AREA)
Applications Claiming Priority (3)
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| US201261710154P | 2012-10-05 | 2012-10-05 | |
| US61/710,154 | 2012-10-05 | ||
| PCT/US2013/063485 WO2014055881A1 (en) | 2012-10-05 | 2013-10-04 | Use of cry1ea in combinations for management of resistant fall armyworm insects |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20150060969A true KR20150060969A (ko) | 2015-06-03 |
Family
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Family Applications (1)
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Country Status (18)
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| US (1) | US20140109263A1 (enExample) |
| EP (2) | EP3395165A1 (enExample) |
| JP (1) | JP2016501511A (enExample) |
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| CN (1) | CN104902744A (enExample) |
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| AR (1) | AR092905A1 (enExample) |
| AU (1) | AU2013326885B2 (enExample) |
| CA (1) | CA2886787A1 (enExample) |
| CL (1) | CL2015000849A1 (enExample) |
| IL (1) | IL238155A0 (enExample) |
| IN (1) | IN2015DN03218A (enExample) |
| MX (1) | MX2015004179A (enExample) |
| PH (1) | PH12015500741A1 (enExample) |
| RU (1) | RU2015116907A (enExample) |
| UY (1) | UY35066A (enExample) |
| WO (1) | WO2014055881A1 (enExample) |
| ZA (1) | ZA201502604B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201542093A (zh) | 2014-03-21 | 2015-11-16 | 艾格里遺傳學股份有限公司 | 用於控制玉米穗蟲之Ｃｒｙ１Ｄ |
| US10487123B2 (en) | 2014-10-16 | 2019-11-26 | Monsanto Technology Llc | Chimeric insecticidal proteins toxic or inhibitory to lepidopteran pests |
| RU2750459C2 (ru) | 2014-10-16 | 2021-06-28 | Пайонир Хай-Бред Интернэшнл, Инк. | Инсектицидные полипептиды с широким спектром активности и их применения |
| SG11201702748TA (en) * | 2014-10-16 | 2017-05-30 | Monsanto Technology Llc | Lepidopteran-active cry1da1 amino acid sequence variant proteins |
| MX388283B (es) * | 2014-10-16 | 2025-03-19 | Monsanto Technology Llc | Proteinas quimericas insecticidas novedosas toxicas o inhibidoras de plagas de lepidopteros. |
| CN114736275A (zh) | 2014-10-16 | 2022-07-12 | 先锋国际良种公司 | 具有改进的活性谱的杀昆虫多肽及其用途 |
| CN114213510B (zh) * | 2014-12-30 | 2025-03-18 | 美国陶氏益农公司 | 可用于控制昆虫害虫的修饰的Cry1Ca毒素 |
| MX392960B (es) | 2016-04-14 | 2025-03-24 | Pioneer Hi Bred Int | Polipeptidos insecticidas que tienen un espectro de actividad mejorado y sus usos. |
| WO2017184392A1 (en) * | 2016-04-19 | 2017-10-26 | Dow Agrosciences Llc | Combination of four vip and cry protein toxins for management of insect pests in plants |
| WO2018060881A1 (en) | 2016-09-27 | 2018-04-05 | University Of Florida Research Foundation, Inc. | Insect toxin delivery mediated by a densovirus coat protein |
| US11878999B2 (en) | 2018-08-29 | 2024-01-23 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8300698A (nl) | 1983-02-24 | 1984-09-17 | Univ Leiden | Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; agrobacterium tumefaciens bacterien en werkwijze voor het produceren daarvan; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten. |
| US5380831A (en) | 1986-04-04 | 1995-01-10 | Mycogen Plant Science, Inc. | Synthetic insecticidal crystal protein gene |
| US4695455A (en) | 1985-01-22 | 1987-09-22 | Mycogen Corporation | Cellular encapsulation of pesticides produced by expression of heterologous genes |
| US4695462A (en) | 1985-06-28 | 1987-09-22 | Mycogen Corporation | Cellular encapsulation of biological pesticides |
| US5296368A (en) * | 1988-10-27 | 1994-03-22 | Mycogen Corporation | Bacillus thuringiensis isolate denoted B.t. PS81F, active against lepidopteran pests, and a gene encoding a lepidopteran-active toxin |
| US5135867A (en) | 1988-11-01 | 1992-08-04 | Mycogen Corporation | Gene encoding a lepidopteran-active toxin from Bacillus thuringiensis isolate denoted B.t. .PS81GG active against lepidopteran pests |
| EP0400246A1 (en) * | 1989-05-31 | 1990-12-05 | Plant Genetic Systems, N.V. | Prevention of Bt resistance development |
| JPH07504087A (ja) | 1992-02-12 | 1995-05-11 | クロマジェン インク | 蛍光性ｎ−ヌクレオシド及び蛍光性ｎ−ヌクレオシド構造類似体の応用 |
| US5527883A (en) * | 1994-05-06 | 1996-06-18 | Mycogen Corporation | Delta-endotoxin expression in pseudomonas fluorescens |
| US5508264A (en) * | 1994-12-06 | 1996-04-16 | Mycogen Corporation | Pesticidal compositions |
| US5942664A (en) * | 1996-11-27 | 1999-08-24 | Ecogen, Inc. | Bacillus thuringiensis Cry1C compositions toxic to lepidopteran insects and methods for making Cry1C mutants |
| US6218188B1 (en) | 1997-11-12 | 2001-04-17 | Mycogen Corporation | Plant-optimized genes encoding pesticidal toxins |
| CA2384967A1 (en) * | 1999-09-15 | 2001-03-22 | Monsanto Technology Llc | Lepidopteran-active bacillus thuringiensis .delta.-endotoxin compositions and methods of use |
| US6551962B1 (en) | 2000-10-06 | 2003-04-22 | Monsanto Technology Llc | Method for deploying a transgenic refuge |
| US7053266B2 (en) * | 2002-03-27 | 2006-05-30 | Council Of Scientfic And Industrial Research | Chimeric cry1E δendotoxin and methods of controlling insects |
| AR048747A1 (es) | 2004-03-05 | 2006-05-24 | Agrigenetics Inc | Combinaciones de cry1ab y cry1fa como una herramienta para el control de la resistencia de los insectos |
| EP1999141B1 (en) * | 2006-03-21 | 2011-06-01 | Bayer BioScience N.V. | Novel genes encoding insecticidal proteins |
| EA200970559A1 (ru) * | 2006-12-08 | 2009-12-30 | Пайонир Хай-Бред Интернэшнл, Инк. | Новые кристаллические полипептиды из bacillus thuringiensis, кодирующие их полинуклеотиды и композиции этих соединений |
| WO2008148223A1 (en) | 2007-06-07 | 2008-12-11 | Agriculture And Agri-Food Canada | Nanocarrier based plant transfection and transduction |
| WO2009046384A1 (en) | 2007-10-05 | 2009-04-09 | Dow Agrosciences Llc | Methods for transferring molecular substances into plant cells |
| WO2009132850A1 (en) | 2008-05-01 | 2009-11-05 | Bayer Bioscience N.V. | Armyworm insect resistance management in transgenic plants |
| US20090313717A1 (en) | 2008-06-16 | 2009-12-17 | Carmen Sara Hernandez | Bollworm insect resistance management in transgenic plants |
| AU2010307119B2 (en) | 2009-10-16 | 2015-04-30 | Corteva Agriscience Llc | Use of dendrimer nanotechnology for delivery of biomolecules into plant cells |
| CN102051337B (zh) * | 2009-10-27 | 2013-06-19 | 行政院农业委员会农业药物毒物试验所 | 一种拮抗害虫的新颖苏云金杆菌菌株 |
| RU2607666C2 (ru) * | 2009-12-16 | 2017-01-10 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | КОМБИНИРОВАННОЕ ПРИМЕНЕНИЕ БЕЛКОВ Vip3Ab И Cry1Fa ДЛЯ ВЫРАБАТЫВАНИЯ РЕЗИСТЕНТНОСТИ К НАСЕКОМЫМ |
| PH12012501429B1 (en) * | 2009-12-16 | 2020-02-05 | Dow Agrosciences Llc | Modified cry1ca insecticidal cry proteins |
| PH12012501433A1 (en) * | 2009-12-16 | 2022-10-05 | Dow Agrosciences Llc | Use of vip3ab in combination with cry1ca for management of resistant insects |
| JP2013514769A (ja) * | 2009-12-16 | 2013-05-02 | ダウ アグロサイエンシィズ エルエルシー | 害虫抵抗性管理のためのＣＲＹ１ＣａおよびＣＲＹ１Ｆａタンパク質の併用 |
| KR101841298B1 (ko) * | 2009-12-16 | 2018-03-22 | 다우 아그로사이언시즈 엘엘씨 | 곤충 내성 관리를 위한 ｃｒｙ1ｄａ 및 ｃｒｙ1ｆａ 단백질의 병용 사용 |
| KR101841296B1 (ko) * | 2009-12-16 | 2018-03-22 | 다우 아그로사이언시즈 엘엘씨 | 곤충 내성 관리를 위한, ｃｒｙ1ｂｅ와 조합된 ｃｒｙ1ｄａ의 용도 |
| UA111814C2 (uk) * | 2009-12-16 | 2016-06-24 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | ТРАНСГЕННА РОСЛИНА, ЯКА МІСТИТЬ Cry1Ab ТА Cry2Aa, ДЛЯ РЕГУЛЮВАННЯ ЄВРОПЕЙСЬКОГО КУКУРУДЗЯНОГО МЕТЕЛИКА І СПОСОБИ БОРОТЬБИ ЗІ СТІЙКІСТЮ КОМАХ |
| BR112012024589A2 (pt) | 2010-03-31 | 2017-06-20 | Dow Agrosciences Llc | peptídeo zeína -gama de planta para liberação de biomoléculas em células de plantas |
| BR112013000434A2 (pt) | 2010-07-07 | 2016-05-17 | Dow Agrosciences Llc | entrega de molécula de dna linear usando pontos quânticos pegilados para transformação estável em plantas. |
| EP2591115B1 (en) | 2010-07-07 | 2018-12-05 | Dow AgroSciences LLC | Production of functionalized linear dna cassette and quantum dot/nanoparticle mediated delivery in plants |
| EP2651208A1 (en) * | 2010-12-16 | 2013-10-23 | Dow AgroSciences LLC | Combined use of vip3ab and cry1ab for management of resistance insects |
-
2013
- 2013-10-04 AP AP2015008351A patent/AP2015008351A0/xx unknown
- 2013-10-04 EP EP18176859.9A patent/EP3395165A1/en not_active Withdrawn
- 2013-10-04 JP JP2015535826A patent/JP2016501511A/ja active Pending
- 2013-10-04 CA CA2886787A patent/CA2886787A1/en not_active Abandoned
- 2013-10-04 AU AU2013326885A patent/AU2013326885B2/en not_active Ceased
- 2013-10-04 MX MX2015004179A patent/MX2015004179A/es unknown
- 2013-10-04 AR ARP130103604A patent/AR092905A1/es unknown
- 2013-10-04 KR KR1020157011245A patent/KR20150060969A/ko not_active Ceased
- 2013-10-04 CN CN201380063218.5A patent/CN104902744A/zh active Pending
- 2013-10-04 RU RU2015116907A patent/RU2015116907A/ru not_active Application Discontinuation
- 2013-10-04 IN IN3218DEN2015 patent/IN2015DN03218A/en unknown
- 2013-10-04 UY UY0001035066A patent/UY35066A/es not_active Application Discontinuation
- 2013-10-04 EP EP13844137.3A patent/EP2903413A4/en not_active Withdrawn
- 2013-10-04 WO PCT/US2013/063485 patent/WO2014055881A1/en not_active Ceased
- 2013-10-07 US US14/047,205 patent/US20140109263A1/en not_active Abandoned
-
2015
- 2015-04-01 PH PH12015500741A patent/PH12015500741A1/en unknown
- 2015-04-02 CL CL2015000849A patent/CL2015000849A1/es unknown
- 2015-04-02 IL IL238155A patent/IL238155A0/en unknown
- 2015-04-17 ZA ZA2015/02604A patent/ZA201502604B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016501511A (ja) | 2016-01-21 |
| UY35066A (es) | 2014-05-30 |
| US20140109263A1 (en) | 2014-04-17 |
| IN2015DN03218A (enExample) | 2015-10-02 |
| PH12015500741A1 (en) | 2015-05-25 |
| MX2015004179A (es) | 2015-06-10 |
| EP3395165A1 (en) | 2018-10-31 |
| EP2903413A1 (en) | 2015-08-12 |
| WO2014055881A1 (en) | 2014-04-10 |
| CL2015000849A1 (es) | 2015-08-28 |
| RU2015116907A (ru) | 2016-11-27 |
| CA2886787A1 (en) | 2014-04-10 |
| AP2015008351A0 (en) | 2015-04-30 |
| EP2903413A4 (en) | 2016-07-20 |
| AU2013326885B2 (en) | 2019-07-04 |
| AU2013326885A1 (en) | 2015-04-30 |
| CN104902744A (zh) | 2015-09-09 |
| IL238155A0 (en) | 2015-05-31 |
| ZA201502604B (en) | 2016-06-29 |
| AR092905A1 (es) | 2015-05-06 |
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