KR20150013170A - 페닐아세트산 전구약물의 치료적 모니터링 방법 - Google Patents

페닐아세트산 전구약물의 치료적 모니터링 방법 Download PDF

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Publication number
KR20150013170A
KR20150013170A KR1020147032114A KR20147032114A KR20150013170A KR 20150013170 A KR20150013170 A KR 20150013170A KR 1020147032114 A KR1020147032114 A KR 1020147032114A KR 20147032114 A KR20147032114 A KR 20147032114A KR 20150013170 A KR20150013170 A KR 20150013170A
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KR
South Korea
Prior art keywords
paa
dose
pagn
prodrug
target range
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Withdrawn
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KR1020147032114A
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English (en)
Korean (ko)
Inventor
브루스 샤르슈미트
마소우드 모크타라니
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하이페리온 쎄라퓨틱스, 인크.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49380684&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20150013170(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 하이페리온 쎄라퓨틱스, 인크. filed Critical 하이페리온 쎄라퓨틱스, 인크.
Priority to KR1020197029026A priority Critical patent/KR102264579B1/ko
Publication of KR20150013170A publication Critical patent/KR20150013170A/ko
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Emergency Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
KR1020147032114A 2012-04-20 2012-09-11 페닐아세트산 전구약물의 치료적 모니터링 방법 Withdrawn KR20150013170A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020197029026A KR102264579B1 (ko) 2012-04-20 2012-09-11 페닐아세트산 전구약물의 치료적 모니터링 방법

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261636256P 2012-04-20 2012-04-20
US61/636,256 2012-04-20
PCT/US2012/054673 WO2013158145A1 (en) 2012-04-20 2012-09-11 Methods of therapeutic monitoring of phenylacetic acid prodrugs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020197029026A Division KR102264579B1 (ko) 2012-04-20 2012-09-11 페닐아세트산 전구약물의 치료적 모니터링 방법

Publications (1)

Publication Number Publication Date
KR20150013170A true KR20150013170A (ko) 2015-02-04

Family

ID=49380684

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020147032114A Withdrawn KR20150013170A (ko) 2012-04-20 2012-09-11 페닐아세트산 전구약물의 치료적 모니터링 방법
KR1020197029026A Active KR102264579B1 (ko) 2012-04-20 2012-09-11 페닐아세트산 전구약물의 치료적 모니터링 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020197029026A Active KR102264579B1 (ko) 2012-04-20 2012-09-11 페닐아세트산 전구약물의 치료적 모니터링 방법

Country Status (25)

Country Link
US (4) US9561197B2 (https=)
EP (2) EP3222275B1 (https=)
JP (3) JP6234436B2 (https=)
KR (2) KR20150013170A (https=)
CN (3) CN113995743A (https=)
AU (3) AU2012377389A1 (https=)
BR (1) BR112014026138A2 (https=)
CL (2) CL2014002807A1 (https=)
CY (1) CY1118838T1 (https=)
DK (1) DK2846791T3 (https=)
EC (1) ECSP14024561A (https=)
ES (2) ES2623470T3 (https=)
HR (1) HRP20170651T1 (https=)
HU (1) HUE032726T2 (https=)
IL (2) IL235127A (https=)
LT (1) LT2846791T (https=)
MX (1) MX365302B (https=)
PL (1) PL2846791T3 (https=)
PT (1) PT2846791T (https=)
RS (1) RS55870B1 (https=)
SG (2) SG10201608749UA (https=)
SI (1) SI2846791T1 (https=)
SM (1) SMT201700219T1 (https=)
WO (1) WO2013158145A1 (https=)
ZA (1) ZA201407597B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2760479T3 (en) 2011-09-30 2017-07-17 Horizon Therapeutics Llc Nitrogen-removing drug for use in a method of treating a nitrogen retention disorder
ES2623470T3 (es) 2012-04-20 2017-07-11 Horizon Therapeutics, Llc HPN-100 para uso en el tratamiento de trastornos de retención de nitrógeno
EP2922576B1 (en) * 2012-11-21 2017-11-08 Horizon Therapeutics, LLC Methods of administering and evaluating nitrogen scavenging drugs for the treatment of hepatic encephalopathy
EP2986325B1 (en) 2013-10-14 2019-06-26 Immedica Pharma AB Methods of treating urea cycle disorders
US20170087113A1 (en) * 2014-06-04 2017-03-30 Horizon Therapeutics, Llc Methods for treating urea cycle disorders to prevent hyperammonemic crises by controlling blood ammonia levels
US9914692B2 (en) 2016-05-25 2018-03-13 Horizon Therapeutics, Llc Procedure for the preparation of 4-phenyl butyrate and uses thereof
US20190076383A1 (en) * 2017-09-08 2019-03-14 Horizon Therapeutics, Llc Methods for treating urea cycle disorders
US10668040B2 (en) 2017-09-11 2020-06-02 Horizon Therapeutics, Llc Treatment of urea cycle disorders in neonates and infants

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284647A (en) 1980-03-31 1981-08-18 The Johns Hopkins University Process for waste nitrogen removal
US4457942A (en) 1982-08-20 1984-07-03 Brusilow Saul W Process for waste nitrogen removal
US5635532A (en) 1991-10-21 1997-06-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Compositions and methods for therapy and prevention of pathologies including cancer, AIDS and anemia
US5879657A (en) 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
ES2157422T3 (es) 1995-02-07 2001-08-16 Brusilow Entpr Llc Trigliceridos y esteres etilicos de acido fenilalcanoico y acido fenilalquenoico utiles en el tratamiento de diversos trastornos.
US6219567B1 (en) 1999-06-21 2001-04-17 Cardiox Corporation Monitoring of total ammoniacal concentration in blood
US20040229948A1 (en) 2002-04-12 2004-11-18 Summar Marshall L. Method for preventing hepatic encephalopathic episodes
US20030195255A1 (en) 2002-04-12 2003-10-16 Summar Marshall L. Method for treating hepatic encephalopathies
US20050273359A1 (en) 2004-06-03 2005-12-08 Young David E System and method of evaluating preoperative medical care and determining recommended tests based on patient health history and medical condition and nature of surgical procedure
SG158073A1 (en) 2004-11-26 2010-01-29 Ucl Business Plc Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy
US20060135612A1 (en) 2004-12-17 2006-06-22 U.S. Department Of Veterans Affairs Method of ameliorating or abrogating the effects of a neurodegenerative disorder, such as amyotrophic lateral sclerosis (ALS), by using a HDAC inhibiting agent
US20070004805A1 (en) 2005-07-01 2007-01-04 Navinta Llc Process for preparation of liquid dosage form containing sodium 4-phenylbutyrate
WO2007059031A2 (en) 2005-11-10 2007-05-24 Massachusetts Institute Of Technology Methods and compositions for raising levels and release of gamma aminobutyric acid
US8094521B2 (en) 2007-02-28 2012-01-10 Nightingale Products LLC Caregiver personal alert device
GB2451259B (en) * 2007-07-25 2011-07-20 Gp Acoustics Loudspeaker
CN101959429B (zh) 2008-01-08 2014-09-10 阿克塞利亚制药公司 抗微生物肽系统的激动剂
PL3133396T3 (pl) 2008-04-29 2019-03-29 Horizon Therapeutics, Llc Sposób leczenia z zastosowaniem leków wychwytujących amoniak
PT3133396T (pt) * 2008-08-29 2018-12-07 Immedica Pharma Ab Métodos de tratamento utilizando fármacos eliminadores de amoníaco
US20120022157A1 (en) * 2008-08-29 2012-01-26 Ucyclyd Pharma, Inc Dosing and monitoring patients on nitrogen-scavenging drugs
AU2010247800A1 (en) * 2009-05-11 2011-12-15 Berg Llc Methods for the diagnosis of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
EP2954780A1 (en) 2009-07-24 2015-12-16 Baylor College Of Medicine Methods of modulation of branched chain acids and uses thereof
US20130224277A1 (en) 2010-08-31 2013-08-29 Institut National De La Sante Et De La Recherche Medicale (Inserm) Porous polysaccharide scaffold comprising nano-hydroxyapatite and use for bone formation
DK2760479T3 (en) 2011-09-30 2017-07-17 Horizon Therapeutics Llc Nitrogen-removing drug for use in a method of treating a nitrogen retention disorder
ES2623470T3 (es) 2012-04-20 2017-07-11 Horizon Therapeutics, Llc HPN-100 para uso en el tratamiento de trastornos de retención de nitrógeno
EP2922576B1 (en) 2012-11-21 2017-11-08 Horizon Therapeutics, LLC Methods of administering and evaluating nitrogen scavenging drugs for the treatment of hepatic encephalopathy

Also Published As

Publication number Publication date
WO2013158145A1 (en) 2013-10-24
SG11201406745VA (en) 2014-12-30
JP2015514757A (ja) 2015-05-21
US20130281530A1 (en) 2013-10-24
ECSP14024561A (es) 2015-09-30
AU2012377389A1 (en) 2014-10-30
CL2014002807A1 (es) 2015-02-27
ES2807951T3 (es) 2021-02-24
HK1208380A1 (en) 2016-03-04
US20180015058A1 (en) 2018-01-18
US20180263938A1 (en) 2018-09-20
AU2019201811B2 (en) 2020-07-09
MX365302B (es) 2019-05-29
IL255918B (en) 2019-06-30
SI2846791T1 (sl) 2017-06-30
IL255918A (en) 2018-01-31
JP2018039830A (ja) 2018-03-15
AU2018200163A1 (en) 2018-02-01
EP2846791A4 (en) 2015-08-19
HUE032726T2 (en) 2017-10-30
HK1243959A1 (en) 2018-07-27
US9561197B2 (en) 2017-02-07
IL235127A (en) 2017-12-31
KR102264579B1 (ko) 2021-06-11
CY1118838T1 (el) 2018-01-10
ZA201407597B (en) 2017-05-31
BR112014026138A2 (pt) 2017-06-27
EP3222275B1 (en) 2020-06-24
EP3222275A1 (en) 2017-09-27
CL2017001375A1 (es) 2018-01-05
PL2846791T3 (pl) 2017-07-31
RS55870B1 (sr) 2017-08-31
JP6234436B2 (ja) 2017-11-22
JP6637941B2 (ja) 2020-01-29
AU2018200163B2 (en) 2018-12-20
CN104540507A (zh) 2015-04-22
SG10201608749UA (en) 2016-12-29
CN111991383A (zh) 2020-11-27
HRP20170651T1 (hr) 2017-06-30
WO2013158145A9 (en) 2014-05-01
SMT201700219T1 (it) 2017-05-08
AU2019201811A1 (en) 2019-04-04
CN113995743A (zh) 2022-02-01
MX2014012694A (es) 2015-06-03
LT2846791T (lt) 2017-04-10
PT2846791T (pt) 2017-05-25
KR20190116552A (ko) 2019-10-14
EP2846791A1 (en) 2015-03-18
DK2846791T3 (en) 2017-03-27
US20170266143A1 (en) 2017-09-21
JP2019219413A (ja) 2019-12-26
ES2623470T3 (es) 2017-07-11
EP2846791B1 (en) 2017-02-08

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US10183006B2 (en) Methods of therapeutic monitoring of nitrogen scavenging drugs
EP2986325B1 (en) Methods of treating urea cycle disorders
HK1243959B (en) Methods of therapeutic monitoring of phenylacetic acid prodrugs
HK1208380B (en) Hpn-100 for use in the treatment of nitrogen retention disorders

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