KR20150002801A - 섬유모세포 성장 인자 21 단백질의 치료 용도 - Google Patents
섬유모세포 성장 인자 21 단백질의 치료 용도 Download PDFInfo
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- KR20150002801A KR20150002801A KR1020147031701A KR20147031701A KR20150002801A KR 20150002801 A KR20150002801 A KR 20150002801A KR 1020147031701 A KR1020147031701 A KR 1020147031701A KR 20147031701 A KR20147031701 A KR 20147031701A KR 20150002801 A KR20150002801 A KR 20150002801A
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- Prior art keywords
- seq
- fgf21 protein
- bone
- fgf21
- pro
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Applications Claiming Priority (5)
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| US201261646974P | 2012-05-15 | 2012-05-15 | |
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| US201361786939P | 2013-03-15 | 2013-03-15 | |
| US61/786,939 | 2013-03-15 | ||
| PCT/US2013/040275 WO2013173158A1 (en) | 2012-05-15 | 2013-05-09 | Therapeutic uses of fibroblast growth factor 21 proteins |
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| KR20150002801A true KR20150002801A (ko) | 2015-01-07 |
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| TN (1) | TN2014000409A1 (enExample) |
| WO (1) | WO2013173158A1 (enExample) |
| ZA (1) | ZA201407532B (enExample) |
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| WO2013006486A2 (en) | 2011-07-01 | 2013-01-10 | Ngm Biopharmaceuticals, Inc. | Compositions, uses and methods for treatment of metabolic disorders and diseases |
| US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
| ES2828505T3 (es) | 2012-11-28 | 2021-05-26 | Ngm Biopharmaceuticals Inc | Composiciones y métodos para el tratamiento de trastornos y enfermedades metabólicos |
| US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| SG10202100667SA (en) | 2012-12-27 | 2021-02-25 | Ngm Biopharmaceuticals Inc | Methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| EP3062881B1 (en) | 2013-10-28 | 2019-10-02 | NGM Biopharmaceuticals, Inc. | Cancer models and associated methods |
| NZ722377A (en) | 2014-01-24 | 2022-09-30 | Ngm Biopharmaceuticals Inc | Binding proteins and methods of use thereof |
| US10398758B2 (en) | 2014-05-28 | 2019-09-03 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions |
| US10456449B2 (en) | 2014-06-16 | 2019-10-29 | Ngm Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| US10293026B2 (en) | 2014-09-08 | 2019-05-21 | Osaka University | Agent for preventing or treating demyelinating disease |
| CN107108711B (zh) | 2014-10-23 | 2021-11-23 | 恩格姆生物制药公司 | 包含肽变异体的药物组合物及其使用方法 |
| WO2016073855A1 (en) | 2014-11-07 | 2016-05-12 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
| US10800843B2 (en) | 2015-07-29 | 2020-10-13 | Ngm Biopharmaceuticals, Inc. | Beta klotho-binding proteins |
| WO2017083276A1 (en) | 2015-11-09 | 2017-05-18 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders |
| EP3503882A4 (en) | 2016-08-26 | 2020-07-29 | NGM Biopharmaceuticals, Inc. | METHOD FOR TREATING FIBROBLAST GROWTH FACTOR-19-MEDIATED CARCINOMAS AND TUMORS |
| CN108324928B (zh) * | 2018-03-05 | 2020-09-08 | 哈尔滨医科大学 | 重组人成纤维细胞生长因子-5在促骨折愈合中的应用 |
| WO2021139744A1 (en) | 2020-01-11 | 2021-07-15 | Beijing Ql Biopharmaceutical Co., Ltd. | Conjugates of fusion proteins of glp-1 and fgf21 |
| EP4288461A4 (en) | 2021-07-14 | 2025-07-02 | Beijing Ql Biopharmaceutical Co Ltd | FUSION POLYPEPTIDES FOR METABOLIC DISORDERS |
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| JP2010523084A (ja) * | 2007-03-30 | 2010-07-15 | アンブルックス，インコーポレイテッド | 修飾ｆｇｆ−２１ポリペプチド |
| AR087973A1 (es) * | 2011-10-04 | 2014-04-30 | Lilly Co Eli | Variantes del factor 21 del crecimiento de fibroblastos |
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- 2013-05-09 CA CA2869320A patent/CA2869320A1/en not_active Abandoned
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- 2013-05-09 AU AU2013263188A patent/AU2013263188A1/en not_active Abandoned
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| JP2015522539A (ja) | 2015-08-06 |
| ZA201407532B (en) | 2016-05-25 |
| IL235482A0 (en) | 2014-12-31 |
| PE20142432A1 (es) | 2015-01-22 |
| CA2869320A1 (en) | 2013-11-21 |
| HK1202800A1 (en) | 2015-10-09 |
| WO2013173158A1 (en) | 2013-11-21 |
| CN104302311A (zh) | 2015-01-21 |
| SG11201407655TA (en) | 2014-12-30 |
| MX2014013913A (es) | 2015-02-17 |
| PH12014502537A1 (en) | 2015-01-21 |
| TN2014000409A1 (en) | 2015-12-21 |
| CO7131381A2 (es) | 2014-12-01 |
| CL2014002846A1 (es) | 2015-01-30 |
| EA201491856A1 (ru) | 2015-03-31 |
| MA37506B1 (fr) | 2017-03-31 |
| US20150141335A1 (en) | 2015-05-21 |
| MA37506A1 (fr) | 2016-01-29 |
| BR112014028413A2 (pt) | 2017-11-07 |
| EP2852398A1 (en) | 2015-04-01 |
| AU2013263188A1 (en) | 2014-10-16 |
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