KR20140135198A - Pak1 억제제로 흑색종을 치료하는 방법 - Google Patents
Pak1 억제제로 흑색종을 치료하는 방법 Download PDFInfo
- Publication number
- KR20140135198A KR20140135198A KR20147025466A KR20147025466A KR20140135198A KR 20140135198 A KR20140135198 A KR 20140135198A KR 20147025466 A KR20147025466 A KR 20147025466A KR 20147025466 A KR20147025466 A KR 20147025466A KR 20140135198 A KR20140135198 A KR 20140135198A
- Authority
- KR
- South Korea
- Prior art keywords
- melanoma
- pak1
- inhibitor
- braf
- patient
- Prior art date
Links
- 0 Cc1c(*)c(Nc2n[n]c(*)c2)nc(N(*)C2(*)*=*2)n1 Chemical compound Cc1c(*)c(Nc2n[n]c(*)c2)nc(N(*)C2(*)*=*2)n1 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261612202P | 2012-03-16 | 2012-03-16 | |
US61/612,202 | 2012-03-16 | ||
PCT/EP2013/055085 WO2013135745A1 (en) | 2012-03-16 | 2013-03-13 | Methods of treating melanoma with pak1 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
KR20140135198A true KR20140135198A (ko) | 2014-11-25 |
Family
ID=47846052
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR20147025466A KR20140135198A (ko) | 2012-03-16 | 2013-03-13 | Pak1 억제제로 흑색종을 치료하는 방법 |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP2844248A1 (zh) |
JP (1) | JP2015511598A (zh) |
KR (1) | KR20140135198A (zh) |
CN (1) | CN104168898A (zh) |
BR (1) | BR112014020173A8 (zh) |
CA (1) | CA2860994A1 (zh) |
HK (1) | HK1200093A1 (zh) |
MX (1) | MX2014010953A (zh) |
RU (1) | RU2014141018A (zh) |
WO (1) | WO2013135745A1 (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016139331A1 (en) * | 2015-03-05 | 2016-09-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of melanoma |
KR101730595B1 (ko) | 2015-03-18 | 2017-05-11 | 충북대학교 산학협력단 | Pak4 억제제를 유효성분으로 포함하는 미백 및 멜라닌 색소 과다 침착 질환의 치료용 조성물 |
Family Cites Families (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
WO1984003506A1 (en) | 1983-03-08 | 1984-09-13 | Commw Serum Lab Commission | Antigenically active amino acid sequences |
NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
CA1247080A (en) | 1983-03-08 | 1988-12-20 | Commonwealth Serum Laboratories Commission | Antigenically active amino acid sequences |
EP0229046B1 (fr) | 1985-03-30 | 1994-05-04 | BALLIVET, Marc | Procede d'obtention d'adn, arn, peptides, polypeptides ou proteines, par une technique de recombinaison d'adn |
NZ215865A (en) | 1985-04-22 | 1988-10-28 | Commw Serum Lab Commission | Method of determining the active site of a receptor-binding analogue |
US5763192A (en) | 1986-11-20 | 1998-06-09 | Ixsys, Incorporated | Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique |
US5266684A (en) | 1988-05-02 | 1993-11-30 | The Reagents Of The University Of California | Peptide mixtures |
US5571689A (en) | 1988-06-16 | 1996-11-05 | Washington University | Method of N-acylating peptide and proteins with diheteroatom substituted analogs of myristic acid |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5663143A (en) | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
US5498538A (en) | 1990-02-15 | 1996-03-12 | The University Of North Carolina At Chapel Hill | Totally synthetic affinity reagents |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
US5698426A (en) | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
US5770434A (en) | 1990-09-28 | 1998-06-23 | Ixsys Incorporated | Soluble peptides having constrained, secondary conformation in solution and method of making same |
AU668347B2 (en) | 1990-11-21 | 1996-05-02 | Torrey Pines Institute For Molecular Studies | Synthesis of equimolar multiple oligomer mixtures, especially of oligopeptide mixtures |
ATE164395T1 (de) | 1990-12-03 | 1998-04-15 | Genentech Inc | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
AU7104294A (en) | 1994-06-10 | 1996-01-05 | Symbiotech, Inc. | Method of detecting compounds utilizing genetically modified lambdoid bacteriophage |
US5627024A (en) | 1994-08-05 | 1997-05-06 | The Scripps Research Institute | Lambdoid bacteriophage vectors for expression and display of foreign proteins |
JPH11511977A (ja) | 1995-09-07 | 1999-10-19 | ノボ ノルディスク アクティーゼルスカブ | 洗剤酵素活性についてのファージ・ディスプレー |
AU715608B2 (en) | 1996-03-20 | 2000-02-03 | Morphosys Ag | Purification of tissue plasminogen activator (tPA) |
WO1997046251A1 (en) | 1996-06-06 | 1997-12-11 | Lajolla Pharmaceutical Company | aPL IMMUNOREACTIVE PEPTIDES, CONJUGATES THEREOF AND METHODS OF TREATMENT FOR aPL ANTIBODY-MEDIATED PATHOLOGIES |
AU735015B2 (en) | 1996-06-10 | 2001-06-28 | Scripps Research Institute, The | Use of substrate subtraction libraries to distinguish enzyme specificities |
US5766905A (en) | 1996-06-14 | 1998-06-16 | Associated Universities Inc. | Cytoplasmic bacteriophage display system |
EP0929361A4 (en) | 1996-10-04 | 2000-07-19 | Whatman Inc | DEVICE AND METHOD FOR SIMULTANEOUS MULTIPLE SYNTHESIS |
DK0934526T3 (da) | 1996-10-08 | 2003-05-05 | Bisys B V U | Fremgangsmåder og midler til udvælgelse af peptider og proteiner, der har specifik affinitet til et mål |
CA2270869A1 (en) | 1996-11-06 | 1998-05-14 | Genentech, Inc. | Constrained helical peptides and methods of making same |
IL119586A (en) | 1996-11-07 | 2001-09-13 | Univ Ramot | Discontinuous library of a single biological unit and a method for its preparation |
IL119587A (en) | 1996-11-07 | 2000-12-06 | Univ Ramot | Method of preparing and for obtaining bimolecular interactions |
US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
AUPP249298A0 (en) | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
US6335155B1 (en) | 1998-06-26 | 2002-01-01 | Sunesis Pharmaceuticals, Inc. | Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules |
EP1141708A1 (en) | 1998-12-28 | 2001-10-10 | Sunesis Pharmaceuticals Inc. | Identifying small organic molecule ligands for binding |
GB9927444D0 (en) | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
IL151781A0 (en) | 2000-03-16 | 2003-04-10 | Genetica Inc | Methods and compositions for rna interference |
WO2004007504A1 (en) | 2002-07-17 | 2004-01-22 | Pharmacia Italia S.P.A. | Heterobicyclic pyrazole derivatives as kinase inhibitors |
MX2007008385A (es) * | 2005-01-10 | 2007-08-21 | Pfizer | Pirrolopirazoles, potentes inhibidores de cinasa. |
MX2007012448A (es) | 2005-04-06 | 2007-10-19 | Astrazeneca Ab | Heterociclos sustituidos y su uso como inhibidores de chk1, pdk1 y pak. |
WO2007023382A2 (en) | 2005-08-25 | 2007-03-01 | Pfizer Inc. | Pyrimidine amino pyrazole compounds, potent kinase inhibitors |
DK1979356T3 (da) | 2005-12-21 | 2013-11-18 | Pfizer Prod Inc | Carbonylaminopyrrolopyrazoler, kraftige kinaseinhibitorer |
WO2009086204A2 (en) | 2007-12-21 | 2009-07-09 | Afraxis, Inc. | Methods for treating neuropsychiatric conditions |
ES2306630B1 (es) | 2008-07-17 | 2009-06-03 | Encarnacion Mira Rodriguez | Dispositivo antiflacidez y antiarrugas. |
WO2010071846A2 (en) | 2008-12-19 | 2010-06-24 | Afraxis, Inc. | Compounds for treating neuropsychiatric conditions |
WO2011044264A2 (en) | 2009-10-06 | 2011-04-14 | Afraxis, Inc. | Pyrrolopyrazoles for treating cns disorders |
EA201270498A1 (ru) | 2009-10-09 | 2012-11-30 | Афраксис, Инк. | 8-этил-6-(арил)пиридо[2,3-d]пиримидин-7(8h)-оны для лечения заболеваний цнс |
WO2011156646A2 (en) | 2010-06-09 | 2011-12-15 | Afraxis, Inc. | 6-(sulfonylaryl)pyrido[2,3-d]pyrimidin-7(8h)-ones for the treatment of cns disorders |
WO2011156640A2 (en) | 2010-06-09 | 2011-12-15 | Afraxis, Inc. | 8-(HETEROARYLMETHYL)PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS |
US20130338153A1 (en) | 2010-06-10 | 2013-12-19 | Afraxis, Inc. | 8-(2'-heterocycyl)pyrido[2.3-d]pyrimidin-7(8h)-ones for the treatment of cns disorders |
WO2011156780A2 (en) | 2010-06-10 | 2011-12-15 | Afraxis, Inc. | 8-(sulfonylbenzyl)pyrido[2,3-d]pyrimidin-7(8h)-ones for the treatment of cns disorders |
WO2011156786A2 (en) | 2010-06-10 | 2011-12-15 | Afraxis, Inc. | 6-(ethynyl)pyrido[2,3-d]pyrimidin-7(8h)-ones for the treatment of cns disorders |
-
2013
- 2013-03-13 MX MX2014010953A patent/MX2014010953A/es unknown
- 2013-03-13 CA CA2860994A patent/CA2860994A1/en not_active Abandoned
- 2013-03-13 BR BR112014020173A patent/BR112014020173A8/pt not_active IP Right Cessation
- 2013-03-13 CN CN201380014567.8A patent/CN104168898A/zh active Pending
- 2013-03-13 RU RU2014141018A patent/RU2014141018A/ru not_active Application Discontinuation
- 2013-03-13 WO PCT/EP2013/055085 patent/WO2013135745A1/en active Application Filing
- 2013-03-13 EP EP13708841.5A patent/EP2844248A1/en not_active Withdrawn
- 2013-03-13 JP JP2014561427A patent/JP2015511598A/ja active Pending
- 2013-03-13 KR KR20147025466A patent/KR20140135198A/ko not_active Application Discontinuation
-
2015
- 2015-01-16 HK HK15100513.1A patent/HK1200093A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP2844248A1 (en) | 2015-03-11 |
RU2014141018A (ru) | 2016-05-10 |
BR112014020173A2 (zh) | 2017-06-20 |
HK1200093A1 (zh) | 2015-07-31 |
JP2015511598A (ja) | 2015-04-20 |
MX2014010953A (es) | 2014-10-13 |
CN104168898A (zh) | 2014-11-26 |
CA2860994A1 (en) | 2013-09-19 |
BR112014020173A8 (pt) | 2017-07-11 |
WO2013135745A1 (en) | 2013-09-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11081236B2 (en) | Diagnostic and therapeutic methods for the treatment of breast cancer | |
Zhang et al. | The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1 | |
JP6900314B2 (ja) | 膀胱癌の治療、診断、及び予後判定方法 | |
Fedorenko et al. | Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma | |
CN109844536B (zh) | 预测对pd-1轴抑制剂的响应 | |
JP2023182572A (ja) | がんの診断及び治療方法 | |
JP2019531699A (ja) | Nrf2及びその遺伝子の下流標的遺伝子の発現状態及び変異状態によるがんの診断及び治療方法 | |
KR20180134347A (ko) | 암의 진단 및 치료 방법 | |
Mahadevan et al. | Alisertib added to rituximab and vincristine is synthetic lethal and potentially curative in mice with aggressive DLBCL co-overexpressing MYC and BCL2 | |
Lang et al. | A phase I study of a dual PI3-kinase/mTOR inhibitor BEZ235 in adult patients with relapsed or refractory acute leukemia | |
WO2013122609A1 (en) | Methods of using cdk8 antagonists | |
US20220313700A1 (en) | Methods for treating map3k8 positive cancers | |
US11696924B2 (en) | Combination therapy using PDK1 and PI3K inhibitors | |
US20230383365A1 (en) | Cancer treatments and methods of selecting same | |
KR20230015888A (ko) | 사시투주맙 고비테칸 요법에 대한 바이오마커 | |
May et al. | Co-targeting PI3K, mTOR, and IGF1R with small molecule inhibitors for treating undifferentiated pleomorphic sarcoma | |
Borneman et al. | Phosphodiesterase 10A (PDE10A) as a novel target to suppress β-catenin and RAS signaling in epithelial ovarian cancer | |
KR20140135198A (ko) | Pak1 억제제로 흑색종을 치료하는 방법 | |
Martin-Broto et al. | Phase II trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A | |
CN115003334A (zh) | 胰腺癌的治疗和预后 | |
US20230076415A1 (en) | Methods and compositions for treating melanoma | |
Dammert | Characterization and therapeutic exploitation of molecular vulnerabilities in genetically defined lung cancer | |
LEPORE SIGNORILE | p38α, the β-catenin chromatin associated kinase, as promising target in colorectal cancer stem cells for personalized therapy | |
Triscott | Polo-like kinase 1 as a prognostic and therapeutic target in high-grade brain tumors | |
Hajdúch | Identification and Characterization of Molecular Basis of Cancer Cell Drug Resistance Mechanisms towards Aurora Kinase Inhibitors CYC116 and ZM447439 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |