KR20140134022A - A composition comprising fruit extract of Camellia japonica having skin whitening effect - Google Patents

Abstract

The present invention relates to a composition containing an extract of a mixture of herb medicines. The composition can be used as a pharmaceutical composition for whitening skin having an excellent whitening effect or as a health-promotional food. The mixture of herb medicines includes 50-300 parts by weight of taraxacum herb, 50-300 parts by weight of clematis berries, 50-300 parts by weight of lycopus herb, and 300-2500 parts by weight of pomegranates with respect to 100 parts by weight of Thesium.

Description

[0001] The present invention relates to a skin whitening composition containing an extract of a herbal mixture,

The present invention relates to a skin whitening composition containing an extract of a crude drug mixture. In detail, an extract of a herbal medicine mixture containing herbaceous plant extracts, herbaceous perilla leaves, turmeric, turmeric, pomegranate and pomegranate or an extract of herbal medicine mixture containing at least one herbal medicine selected from chicken herb, perfume, pear, To a skin whitening composition.

Skin is the primary organ that protects or defends the body. It is the largest organ covering the entire body surface, consisting of epidermis, dermis and subcutaneous tissue. The stratum corneum, which is located on the outermost layer of the epidermis, is composed of keratin and lipid while inhibiting penetration of harmful substances and moisture evaporation, and protecting the body from bacteria and external stimuli. The stratum corneum is newly formed at 4 weeks (28 days). In addition, fibroblasts, which are mainly distributed in the upper part of the dermis, act as a blastocyst producing collagen and elastin, fiber proteins having skin elasticity function and protection function.

On the other hand, Asian people have a higher desire for whitening than any other continent, regardless of gender, and the desire for whitening is soon becoming an important element of confidence. Human skin color is determined by the amount of melanin synthesized in melanocytes called melanocytes in the basal layer of skin. Genetic factors are most important depending on concentration and distribution, It is also affected by the sun's ultraviolet rays, fatigue, stress, environmental or physiological conditions such as pregnancy.

Melanin is distributed throughout the body, absorbing the visible light of the sun to protect the skin from sunlight. Therefore, the closer to black skin is, the more resistant it is to sunlight exposure as well as light damage.

Whitening is induced by inhibiting the enzyme activity of tyrosinase or promoting the reduction of already produced melanin pigment. Tyrosine, which is produced from the melanocyte melanocyte present in the epidermis of the skin, corresponds to a precursor of melanin and is synthesized as melanin via dopaquinone (DOPA-quinone). In this intermediate process, tyrosinase inhibits the activity of tyrosinase, which is involved in the oxidation of tyrosine to dopa and dopachrome, thereby inhibiting melanin production, Brightening whitening effect appears.

Prunella vulgaris is a perennial herbaceous outpost of Lamiaceae belonging to Lamiaceae. It is a medicinal herb that has many calyxes and leaves attached to its flowers, stems on its lower part and small hairs of white birds. And there is little taste. It is said to be in the summer when other plants grow vigorously, and it is called candles. It is good to be used as a medicinal product in which the shape of the flower is yellowish brown and dried without breaking. And the candle cleanses the liver (肝气) and releases the urine (acupuncture), acute mastitis, breast cancer, night-time eye pain, difficult to see the light and tears, dizziness of the head and eyes, Is known as a medicine to treat.

Pogongyoung (蒲公英) is a sentinel of dandelion (Taraxacum platycarpum) or as dried herbs dongsok plant of the Asteraceae, Chinese, we use the Taraxacum mongolicum, Taraxacum sinicum. It is also called a geography because the flower is like a head of a golden woman, and it is called "Gimsocho". This medicine has almost no odor, it has taste, it is sweet, and its quality is cold. It is used for symptoms such as swelling, mastitis, sore throat, sore throat (appendicitis, lung abscesses, peritonitis), eye congestion, acute hepatitis, jaundice and fever. The pharmacological action was reported to be the insecticidal action, the immune function enhancement, the bile secretion action, the liver function protection action, and the diuretic action.

Fruit is also called fruit (燕 附 子), and it is a fruit of Ahnimyeo (林下 婦人 , Akebia quinata ), and it is a fruit of ephedra (气 热) ), And is a medicinal substance with insecticidal effect. Fruit is delicious and edible, but contains a lot of seeds. It is similar in appearance and taste to banana, so it is also called 'Korean banana'.

Tacan ( Lycopus lucidus ) is a subterranean part of the flower before it blooms. It is also called a branch because it can be eaten roots, because it grows around the pond. This medicine has no odor, has a very high taste and is slightly warm. Takan is used for amenorrhea caused by hemorrhage, menstrual pain, postpartum abdominal pain, bruise, boil, liver dysfunction and postpartum voiding. Among the medicines that release the eosinophil, it has a merit that it does not damage the periodic, so it is widely applied to gynecology. Radiation has been reported as a pharmacological action.

Pomegranate (pomegranate) is the fruit of the pomegranate. It is round to 6 ~ 8cm in diameter and has a hard, yellowish skin. There are many seeds in the pulp. There is about 20% of the portion that can be eaten, but the flesh flavor is sweet and sour, and the skin is used as medicine. The type is divided into strong acidity and strong sense of sweetness and acidity. Origin is located in West Asia and northwest India, and Korea is estimated to have come from China in early Goryeo. The major components are saccharides (glucose, fructose), about 40%, and organic acids contain about 1.5% citric acid, which gives a sour taste. Water-soluble vitamins (B1, B2, niacin) are also present, but the amount is low. The skin contains tannins and seeds contain natural vegetable estrogens that are good for menopausal disorders. Both fruit and skin are good for hypertension, prevention of arteriosclerosis, gynecological diseases, swelling. Especially, it has excellent effect when it gets dysentery, and it contains volatile alkaloids and is used as a parasite, especially tapeworm. Nectar is used to make beverages and confectionery by dipping green fruit juice and concentrated juice. It mixes with olive oil to make good oil for constipation.

The chicken leg is the part of the chicken below the ankle, that is, the foot where the legs are removed and the toes where the toenails are cut. Chickens have fewer muscles and bones and shells. The bones are not thick but cartilage-shaped, and the skin has many connective tissue proteins such as collagen and elastin. Chicken legs are mainly composed of glycine-like glycoproteins because they have less muscle and fat and only tendons and shells. Chondroitin contains many chondroitin components. Chicken legs have long been known to be good for degenerative arthritis. Recently, it has been known that collagen, which is contained in chicken legs, is good for skin beauty and blood pressure lowering. In addition, DHA and EPA have been shown to help children's brain development and growth, while chitin and chitosan have been shown to help in hemostatic function and immunity.

Perfumery ( Elsholtzia ciliata ) is a first year of Lamiaceae. It is also commonly used for the treatment of sweating, fever, diuretic, sweating as a hemostatic agent, each species, species, gastritis, hematocrit and bad breath.

Pear (pear) is a fruit of the pear tree, and it is effective for bronchial diseases, and it is good for cold, relieving, asthma, and helps defecation and diuretic action. It removes sputum and cough, relieves symptoms when the throat is resting or when the stomach is cold and sick, and also helps in treating the boils. In addition, there is a detoxifying action to eliminate hangovers.

Macromuscular ( Liriope platyphylla ) uses root roots as herbs, which are used as anti-inflammatory, tonic, shinhae, expectorant and cardiovascular agents.

Mosquito is a fruit of a quince tree, which is similar to a melon that runs on a tree, and it is also called a tree or a tree. In one room, it is medicinal because it has the efficacy of Sujun, Cheongan, Hwa Stom, Dehumidification, Hematopoiesis. The weakness is warm and acid, and the treatment effect is high for neuralgia, muscle pain, dyspepsia, 脚气, edema, sea cough, anemia.

Gakgyeong is a medicinal product made by removing roots or juniors of Platycodon grandiflorum A. De Candolle, which is a little bit odorous, has a very good taste, and has a fairly flat quality. Gyungyung works on the lungs to treat symptoms with a lot of seawater and sputum, uncomfortable breathing, clearing the lungs, releasing the stiff chest, releasing cold air in the stomach, stopping the cough and removing the wall. I do not see my urine, I have generalized edema, and even when the amount of urine is small. Sore throat, cold cough, sputum, nasal congestion, asthma, bronchial inflammation, pleurisy, headache, chills and tonsillitis. The pharmacological action was reported to be a gadam action, a hypoglycemic action, a cholesterol lowering action, and an inhibiting action of improving bacteria.

On the other hand, the inventors of the present invention have been studying on a whitening composition, and have found that when a whitening composition is mixed with a herbal medicine mixture containing herbaceous, porcine, vermiculite, turmeric and pomegranate or a herbal medicine selected from chicken hair, The present inventors have completed the present invention by confirming that the extract of the crude drug mixture to which one or more kinds of the herbal composition is added has a whitening effect.

Korean Patent No. 1027447, Doraji (Gyeonggyeong), Korean Registered Patent No. 851408, Dandelion (Pokyoung), Korean Registered Patent No. 758708, Pomegranate, Korean Patent Publication No. 2005-0018321, Compositions or cosmetic compositions containing the same have been disclosed, but the prior art including all herbal medicines disclosed in the present invention has not been found.

Korean Patent No. 1027447 (Cosmetic Composition Containing Abalone Extract and Method for Producing the Same, Registered on Mar. 30, 2011) Korean Registered Patent No. 851408 (registered herbal medicine composition, 2008.08.04.) Korean Patent No. 758708 (Skin lotion and its manufacturing method, registered on September 7, 2007) Korean Patent Publication No. 2005-0018321 (herbal medicine herbal extract having excellent skin whitening effect, its preparation method and its use, published on Feb. 23, 2005)

It is an object of the present invention to provide a skin whitening composition containing an extract of a crude drug mixture. In detail, an extract of a herbal medicine mixture containing herbaceous plant extracts, herbaceous perilla leaves, turmeric, turmeric, pomegranate and pomegranate or an extract of herbal medicine mixture containing at least one herbal medicine selected from chicken herb, perfume, pear, And to provide a skin whitening composition containing the same.

The present invention relates to a composition for skin whitening comprising an extract of a herbal medicine mixture comprising a herbal composition, a herbal composition, a sunflower seed oil, a turmeric, and a pomegranate.

The herbal medicine mixture may contain 50 to 300 parts by weight of pearly root, 50 to 300 parts by weight of fruit root, 50 to 300 parts by weight of tacrine and 300 to 2,500 parts by weight of pomegranate, based on 100 parts by weight.

50 to 300 parts by weight of chickpea, 50 to 300 parts by weight of perfume, 300 to 2500 parts by weight of pear, 50 to 300 parts by weight of germanium, 50 to 300 parts by weight of germanium and 50 to 300 parts by weight of germanium, And 300 parts by weight of a herbal medicine.

The extract of the crude drug mixture can be prepared by extracting a crude drug mixture containing chrysotile, porcine, fructose, cherry, tacrine and pomegranate with water, C1 to C4 lower alcohol or a mixed solvent thereof.

The present invention also provides a skin-whitening health functional food containing the above-mentioned extract of a herbal medicine mixture containing the above-mentioned ingredients, herbaceous fungi, seed oil, tacrine and pomegranate.

According to another aspect of the present invention,

(1) 100 parts by weight, 50-300 parts by weight of porphyrin, 50-300 parts by weight of fleshy fruit, 50-300 parts by weight of tacrine and 300-2500 parts by weight of pomegranate to prepare a herbal mixture;

(Step 2) Extraction of 1 to 10 times the total weight of the crude drug mixture with the herbal mixture in the above-mentioned one step and extraction at 70 to 100 ° C for 1 to 10 hours; And

(Step 3) The solid content of the extract of the above two steps is removed and the filtrate is collected.

50 to 300 parts by weight of chickpea, 50 to 300 parts by weight of perfume, 300 to 2500 parts by weight of pear, 50 to 300 parts by weight of germanium, 50 to 300 parts by weight of germanium and 50 to 300 parts by weight of germanium, And 300 parts by weight of a herbal medicine.

Hereinafter, the present invention will be described in detail.

The extract of the crude drug mixture can be used by concentrating the extract at a reduced pressure when a C1 to C4 lower alcohol or a mixed solvent with water is used. In addition, in the case of extraction using water, the filtrate from which the solid content has been removed can be immediately used, and it can also be used in the form of a concentrated liquid under reduced pressure.

Among the herbal medicines contained in the herbal medicine mixture, pomegranate and pear are preferably used without fresh drying process. Also, it is preferable to use chicken broth without any additional drying process in the state of being collected from chicken, It is preferable to use a dried one. The pomegranate and the pear are preferably made of the entire fruit.

The extract of the crude drug mixture may be isolated by known methods used for separation and extraction of plant components, such as extraction with an organic solvent (alcohol, ether, acetone, etc.), partition with hexane and water, Or may be fractionated or purified by a suitable combination method.

The chromatography can be carried out using silica gel column chromatography, LH-20 column chromatography, ion exchange resin chromatography, medium pressure liquid chromatography chromatography, thin layer chromatography (TLC), silica gel vacuum liquid chromatography, and high performance liquid chromatography.

In addition, the present invention provides a pharmaceutical composition for skin whitening comprising an extract of a herbal medicine mixture comprising pomegranate, pomegranate, pomegranate fruit, turmeric and pomegranate. The pharmaceutical composition comprising the extract of the crude drug mixture may be administered orally or parenterally in the form of powders, granules, tablets, capsules, suspensions, emulsions, syrups and aerosols, external preparations, suppositories, Can be used. Examples of carriers, excipients and diluents that can be contained in the pharmaceutical composition include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose , Methylcellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil. In the case of formulation, a diluent or excipient such as a filler, an extender, a binder, a wetting agent, a disintegrant, or a surfactant is usually used. Solid formulations for oral administration include tablets, pills, powders, granules, capsules and the like, which may contain at least one excipient, such as starch, calcium carbonate, sucrose, Or lactose, gelatin and the like. In addition to simple excipients, lubricants such as magnesium stearate and talc are also used. Examples of the liquid preparation for oral use include suspensions, solutions, emulsions, and syrups. In addition to water and liquid paraffin, simple diluents commonly used, various excipients such as wetting agents, sweeteners, fragrances, preservatives and the like may be included . Formulations for parenteral administration include sterilized aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations, and suppositories. Examples of the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like. Examples of suppository bases include witepsol, macrogol, tween 61, cacao butter, laurin, glycerogelatin, and the like.

The dosage of the skin whitening pharmaceutical composition containing the extract of the herbal composition of the present invention may vary depending on the age, sex, and weight of the subject to be treated, the specific disease or condition to be treated, the severity of the disease or condition, . Dosage determinations based on these factors are within the level of ordinary skill in the art and generally the dosage ranges from 0.01 mg / kg / day to approximately 2000 mg / kg / day. A more preferable dosage is 1 mg / kg / day to 500 mg / kg / day. The administration may be carried out once a day or divided into several times. The dose is not intended to limit the scope of the invention in any way.

The pharmaceutical composition for skin whitening containing the extract of the herbal composition of the present invention can be administered to mammals such as rats, livestock, humans, and the like in various routes. All modes of administration may be expected, for example, by oral, rectal or intravenous, intramuscular, subcutaneous, intra-uterine dural or intracerebral injection. Since the composition for skin whitening of the present invention has little toxicity and side effects, it can be safely used for long-term use for preventive purposes.

In addition, the present invention provides a skin whitening health functional food comprising an extract of a herbal medicine mixture comprising pomegranate, pomegranate, pomegranate, turmeric and pomegranate, and a pharmaceutically acceptable food-aid additive. The health functional food of the present invention includes forms such as tablets, capsules, pills, and liquids. Examples of the foods to which the extract of the present invention can be added include various foods, beverages, gums, tea, vitamins , And health functional foods.

On the other hand, the pharmaceutical whitening composition for skin whitening or the health functional food containing the extract of the herbal medicine mixture containing the herbal composition, the glutinous rice porcine, the glutinous fruit, the sorghum fruit, the tacrine and the pomegranate can be provided as a form easily sterilized and packed in the pouch form.

The present invention relates to a composition containing an extract of a herbal medicine mixture comprising a herbal mixture comprising a herbal composition comprising a herbal composition, a pomegranate extract, a pomegranate fruit, a tacrine and a pomegranate. It is easy to use as a functional food.

FIG. 1 is a flow chart showing a process for producing an extract of a herbal medicine mixture containing herbaceous, porcine, jujube fruit, tacrine and pomegranate.

Hereinafter, preferred embodiments of the present invention will be described in detail. However, the present invention is not limited to the embodiments described herein but may be embodied in other forms. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the concept of the invention to those skilled in the art.

<Example 1> Preparation of Extracts of Herbal Drug Mixtures Including Parsley, Porcine, Fruits, Turmeric and Pomegranate>

The crude drug mixture of Table 1 below was mixed with 8 kg of water and extracted with a herbal extractor at 100 ° C for 4 hours. The solids were removed to obtain an extract of each crude drug mixture. At this time, the total weight of the crude drug mixture was unified to 4900 g. Of the herbal medicines for the preparation of the extracts, pomegranate and pears were freshly squeezed without any drying process, and the chicken legs were directly used in the state of being collected from raw chicken without any drying process. The other herbal medicine was dried.

Condition Weight (g) And seconds POE The
Fruit Tacane Pomegranate Chicken leg enjoyment ship McMundong Quince Gakyung Example 1-1 200 200 200 200 4100 0 0 0 0 0 0 Examples 1-2 200 100 100 100 3000 400 200 0 400 0 400 Example 1-3 200 600 600 600 600 0 0 1900 0 400 0 Examples 1-4 200 100 600 100 600 200 0 2600 0 0 500 Examples 1-5 200 600 100 600 2600 0 400 0 400 0 0 Examples 1-6 100 300 300 300 2500 300 0 800 0 0 300 Examples 1-7 600 600 600 600 1800 700 0 0 0 0 0 Examples 1-8 600 600 600 600 1800 0 700 0 0 0 0 Examples 1-9 400 400 400 400 1200 0 0 2100 0 0 0 Example 1-10 600 600 600 600 1800 0 0 0 700 0 0 Example 1-11 600 600 600 600 1800 0 0 0 0 700 0 Examples 1-12 600 600 600 600 1800 0 0 0 0 0 700 Examples 1-13 100 100 100 100 2000 100 100 2000 100 100 100

< Comparative Example  1. Preparation of comparative extracts>

The crude drug mixture of Table 2 below was mixed with 8 kg of water and extracted with a herbal extractor at 100 ° C for 4 hours. The solid content was removed to obtain an extract of each herbal mixture. At this time, the total weight of the crude drug mixture was unified to 4900 g.

Condition Weight (g) And seconds POE Good fruit Tacane Pomegranate Comparative Example 1-1 1600 1600 0 1700 0 Comparative Example 1-2 0 1600 0 1600 1700 Comparative Example 1-3 0 0 2400 0 2500 Comparative Example 1-4 1600 0 1700 0 1600 Comparative Example 1-5 0 2000 2900 0 0 Comparative Example 1-6 2400 0 0 2500 0 Comparative Example 1-7 200 1000 50 800 2850

EXPERIMENTAL EXAMPLE 1 Confirmation of inhibition of tyrosinase of an extract of crude drug mixture &gt;

L-tyrosine was administered to a concentration of 1.5 mM in 0.1 M sodium phosphate buffer (pH 6.8), and the lyophilized dried extract of Example 1 and Comparative Example 1 was dissolved again in water to give a solution of tyrosine After incubating at 37 ° C for 30 minutes, the absorbance was measured at 475 nm using a spectrophotometer. Table 3 shows the half maximal inhibitory concentration (IC ₅₀ ) of the extract of Example 1 and Comparative Example 1 when the tyrosinase activity was inhibited by 50%.

Tyrosinase inhibitory activity IC ₅₀ (mg / ml) Example 1-1 5.76 Examples 1-2 4.55 Example 1-3 3.84 Examples 1-4 4.56 Examples 1-5 3.65 Examples 1-6 2.74 Examples 1-7 4.87 Examples 1-8 4.46 Examples 1-9 2.45 Example 1-10 3.34 Example 1-11 3.23 Examples 1-12 3.36 Examples 1-13 1.45 Comparative Example 1-1 42.34 Comparative Example 1-2 53.43 Comparative Example 1-3 53.65 Comparative Example 1-4 46.22 Comparative Example 1-5 54.35 Comparative Example 1-6 51.44 Comparative Example 1-7 30.67

Referring to Table 3, the extract of the crude drug mixture of Example 1 showed significantly higher tyrosinase inhibitory activity than the extract of Comparative Example 1. In particular, the tyrosinase inhibitory effect of the extract of Example 1-13, which contains chicken wings, ointment, pears, ginseng, corn, ginseng, and ginseng in addition to ginseng root, ginseng root,

EXPERIMENTAL EXAMPLE 2. Confirmation of whitening effect by taking an extract of a crude drug mixture < RTI ID = 0.0 >

From Sep. 2012, the extract was administered to women of 30 to 50 years old for 7 days for each extract of Example 1 and Comparative Example 1, 110 ml of the extract for 3 days, 40 days, and 2 hours after the meal. After 40 days of administration , And the whitening effect was shown by the 5-point spotting method (5 points: excellent, 4 points: excellent, 3 points: normal, 2 points: poor, 1 point: very poor)

Condition Whitening effect Example 1-1 3.9 Examples 1-2 4.0 Example 1-3 4.2 Examples 1-4 4.3 Examples 1-5 4.2 Examples 1-6 4.3 Examples 1-7 4.2 Examples 1-8 4.3 Examples 1-9 4.2 Example 1-10 4.1 Example 1-11 4.3 Examples 1-12 4.2 Examples 1-13 4.6 Comparative Example 1-1 2.3 Comparative Example 1-2 2.4 Comparative Example 1-3 2.5 Comparative Example 1-4 2.4 Comparative Example 1-5 2.3 Comparative Example 1-6 2.2 Comparative Example 1-7 2.8 5 points: Excellent, 4 points: Excellent, 3 points: Normal, 2 points: Poor, 1 point: Very poor

Referring to Table 4, the extract of the crude drug mixture of the present invention showed excellent whitening effect. In particular, it was confirmed that the whitening effect of the extract of Example 1-13, which includes chicken wings, ointment, pears, ginseng, mokwha, gyeonggye,

<Experimental Example 3> Toxicity test>

Experimental Example 3-1. Acute toxicity

To investigate the toxicity of the herbal mixture (lyophilized product) of Examples 1-13 of the present invention to an animal body in an acute (within 24 hours) when an excessive amount of the herbal extract was in a short period of time, and to determine the mortality rate, Respectively. Twenty ICR mice were injected into each of the control and experimental groups. In the control group, only the PEG-400 / tween-80 / EtOH (8/1/1, v / v / v) -80 / EtOH (8/1/1, v / v / v) for oral administration. As a result, the mice were found to survive in the control group and in the experimental group administered with the herbal mixture extract of Example 1-13 of the present invention at a concentration of 2 g / kg / day.

Experimental Example 3-2. Organ organs toxicity test in experimental group and control group

In the long-term toxicity test, the extract (lyophilisate) of the crude drug mixture of Examples 1-13 of the present invention was administered to C57BL / 6J mice (10 rats per group) for 8 weeks at each concentration. In order to investigate the effect on the organs (tissues) of animals, the experimental group to which the extract of crude drug mixture of Example 1-13 of the present invention was administered and the PEG-400 / tween-80 / EtOH (8/1/1, v / 8 weeks after the administration of v / v alone, the blood was collected and the concentration of glutamate-pyruvate transferase (GPT) and blood urea nitrogen (BUN) in the blood was measured using a Select E (Vital Scientific NV, Respectively. As a result, GPT, which is known to be related to hepatotoxicity, and BUN, which is known to be related to renal toxicity, showed no significant difference compared to the control group. In addition, liver and kidney were cut from each animal, followed by a general tissue section preparation, histological observation with an optical microscope, and no abnormalities were observed in all tissues.

&Lt; Formulation Example 1: Pharmaceutical preparation >

1-1. Manufacture of tablets

200 g of the extract (lyophilized product) of the crude drug mixture of Example 1-13 of the present invention was mixed with 175.9 g of lactose, 180 g of potato starch and 32 g of colloidal silicic acid. To this mixture was added a 10% gelatin solution, which was pulverized and passed through a 14-mesh sieve. This was dried, and a mixture obtained by adding 160 g of potato starch, 50 g of talc and 5 g of magnesium stearate was made into tablets.

1-2. Injection preparation

1 g of the extract (lyophilized product) of the crude drug mixture of Example 1-13 of the present invention, 0.6 g of sodium chloride and 0.1 g of ascorbic acid were dissolved in distilled water to make 100 ml. This solution was placed in a bottle and sterilized by heating at 20 DEG C for 30 minutes.

&Lt; Formulation Example 2: Food Preparation >

2-1. Manufacture of cooking seasonings

The livestock mixture extract (lyophilized product) of Example 1-13 of the present invention was added to the cooking seasoning at 1 wt% to prepare a cooking sauce for health promotion.

2-2. Manufacture of flour food products

(Lyophilized product) of the crude drug mixture of Example 1-13 of the present invention was added to wheat flour at 0.1 wt%, and bread, cake, cookies, crackers and noodles were prepared using the mixture to prepare health promotion foods Respectively.

2-3. Manufacture of soups and gravies

The health enhancing soup and the juice were prepared by adding the extract (lyophilized product) of the crude drug mixture of Example 1-13 of the present invention to the soup and juice at 0.1 wt%.

2-4. Manufacture of dairy products

The lyophilized product extract (lyophilized product) of Example 1-13 of the present invention was added to milk in an amount of 0.1% by weight and various dairy products such as butter and ice cream were prepared using the milk.

2-5. Vegetable juice manufacturing

0.5 g of the herbal composition extract (lyophilized product) of Example 1-13 of the present invention was added to 1,000 ml of tomato juice or carrot juice to prepare vegetable juice for health promotion.

2-6. Manufacture of fruit juice

0.1 g of the herbal mixture extract (lyophilized product) of Example 1-13 of the present invention was added to 1,000 ml of apple juice or grape juice to prepare fruit juice for health promotion.

Claims (10)

Wherein the composition for skin whitening comprises an extract of a herbal medicine mixture containing a herbicidal composition, herb extract, sunflower seed oil, turmeric, and pomegranate. The method according to claim 1,
Wherein the herbal medicine mixture comprises 50 to 300 parts by weight of a whitening starch, 50 to 300 parts by weight of fruit starch, 50 to 300 parts by weight of turban, and 300 to 2,500 parts by weight of pomegranate, / RTI &gt; 3. The method of claim 2,
50 to 300 parts by weight of chickpea, 50 to 300 parts by weight of herbal oil, 300 to 2500 parts by weight of pear, 50 to 300 parts by weight of germanium, 50 to 300 parts by weight of germanium and 50 to 300 parts by weight of germanium, And at least one herbal medicine selected from the group consisting of at least one herbicide and at least one herbicide. 4. The method according to any one of claims 1 to 3,
A composition for skin whitening characterized in that the extract of the crude drug mixture is prepared by extracting a crude drug mixture containing chrysotile, porpoelast, fruit juice, tarsin and pomegranate with water, C1 to C4 lower alcohol or a mixed solvent thereof . Which comprises extracts of a herbal medicine mixture containing herbaceous plant extracts, herbaceous plants, seeds, turmeric and pomegranate. 6. The method of claim 5,
Wherein the herbal medicine mixture comprises 50 to 300 parts by weight of a whitening starch, 50 to 300 parts by weight of fruit starch, 50 to 300 parts by weight of turban, and 300 to 2,500 parts by weight of pomegranate, Health functional food for. 6. The method of claim 5,
50 to 300 parts by weight of chickpea, 50 to 300 parts by weight of herbal oil, 300 to 2500 parts by weight of pear, 50 to 300 parts by weight of germanium, 50 to 300 parts by weight of germanium and 50 to 300 parts by weight of germanium, By weight of at least one herbal medicine selected from the group consisting of at least one herbal medicine for skin whitening. 8. The method according to any one of claims 5 to 7,
Wherein the extract of the crude drug mixture is prepared by extracting a crude drug mixture comprising chrysotile, porcine perch, fruit berries, turmeric and pomegranate with water, C1 to C4 lower alcohol or a mixed solvent thereof. Functional foods. (1) 100 parts by weight, 50-300 parts by weight of porphyrin, 50-300 parts by weight of fleshy fruit, 50-300 parts by weight of tacrine and 300-2500 parts by weight of pomegranate to prepare a herbal mixture;
(Step 2) Extraction of 1 to 10 times the total weight of the crude drug mixture with the herbal mixture in the above-mentioned one step and extraction at 70 to 100 ° C for 1 to 10 hours; And
(Step 3) removing the solid content of the extract of the two steps and collecting the filtrate;
&Lt; / RTI &gt; wherein the crude extract is prepared via the method of claim 1. 10. The method of claim 9,
50 to 300 parts by weight of chickpea, 50 to 300 parts by weight of perfume, 300 to 2500 parts by weight of pear, 50 to 300 parts by weight of germanium, 50 to 300 parts by weight of germanium, And 50 to 300 parts by weight of at least one herbal medicine selected from the group consisting of at least one herb medicine.

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