KR20140105245A - method for manufacturing pill containing korean herbal extract, and pill produced thereby - Google Patents

Abstract

The present invention relates to a method for manufacturing a pill comprising herbal material as a main component by extracting with hot water and fermenting the same, and a pill manufactured by the method. The pill comprising the herbal material extract manufactured by the method of the present invention: has high content of useful components of herbal materials in pills by inhibiting loss or degradation of useful components in the extraction process of useful components of herbal materials; can be stored for a long period time by delaying corruption of pills; costs less for manufacturing since the extraction process is simple; can be sufficiently absorbed in stomach by rapidly disintegrating in the stomach after ingestion since the pill is coated with Chinese yam powder, thereby is easy to carry and consume, and shortens the disintegration time; and is less objectionable for weak patients, children, and elderly to eat by suppressing stimulation of stomach due to pharmacological components of the herbal material.

Description

The present invention relates to a method for manufacturing a pine containing a herbal material extract and a method for producing the same,

The present invention relates to a method for producing a ring by fermenting a hot-water extract with a herbal material as a main ingredient, and a ring made by the method.

Due to the development of the industrial economy, the pattern of the dietary life structure of modern people has been gradually transformed and diversified into a Western diet. As a result, the consumption of rice has decreased and the preference of dietary life has changed due to the overflowing of processed food or fast food by flour or meat And it is a reality that there is a nutritional imbalance and it is against the promotion of the public health.

Because of these causes, modern diseases that have not been treated in the past, such as incurable diseases, incurable diseases, obesity, diabetes, hypertension and arteriosclerosis, which are not treated by modern medicine and medicine, are increasing. However, synthetic antibiotics And there are side effects.

In addition, modern people who have difficulties in solving the problems of food, clothing and shelter as the level of income increases, have a strong desire to pursue new foods and tastes, and are especially inclined to favor healthy and healthy foods.

As a result, the preference for food is merely changing the nutritional and health-centered meaning, which means prolonging the life phenomenon, with the meaning of survival. Accordingly, a functional health food satisfying both functionality and palatability has appeared, Is increasing.

As a kind of health food, there is an increasing interest in oriental herbal ingredients. Herbal oriental herb is a plant which is dried or processed in plants which have pharmacological effects and grows in nature. Herbal oriental herb has been widely used In recent years, there has been an increasing tendency for herbal materials to be easily ingested or added to foods.

As an example of this, Korean Patent Registration No. 0617500 discloses a method for producing a granular material by mixing and pulverizing a herbal medicine material, adding purified water of 5 to 10 times the total weight of the raw material to the pulverized material, A step of performing circulation extraction for about 3 hours, a step of obtaining a filtrate by solid-liquid separation of the extracted product, a step of performing ultrafiltration on the obtained filtrate, and a step of concentrating the recovered permeate, A method for producing the same is disclosed.

The present invention is advantageous for use as a raw material for beverages because microorganisms are removed while maintaining the inherent color, flavor and nutrients of herbal materials, and there is no precipitate. However, the herbal medicine in liquid form is difficult to be stored, , It is disadvantageous to give a stimulus to the above when consumed and to take a person having a weak gastrointestinal function or a person having a strong sense of taste and fragrance.

In order to solve such a problem, Korean Patent Registration No. 0826902 discloses a method for producing a fermented starch by firstly fermenting a herb medicinal material, a raw material, a wild plant, a fruit tree, and a cereal grain with a stock solution of a fermented enzyme in which a mixture of pear, pineapple, There is disclosed a method for producing a functional herbal fermentation broth by secondary fermentation after mixing with a solution containing sugar and a sugar solution prepared by dipping the medicinal herb, followed by aging.

The present invention has the effect of refining the strong taste and aroma of herbal medicines by fermenting herbal medicines, wild grasses and the like to reduce the feeling of rejection of eating, but it is inconvenient to carry, fermented and fermented, .

Also, Korean Patent Registration No. 1229446 discloses a method for preparing a hot-water extract of a first medicinal material comprising a plant herb for the preparation of a herbal medicine; Lyophilized and pulverized to obtain a pharmacological powder; Preparing a cheonggukjang, followed by drying and pulverizing to obtain an expanding agent of chungkukjang powder; And mixing the pharmacological powder and the bulking agent.

The herbal medicine powder produced by the above method can remove the indigestible substances contained in the pharmacological medicinal material through the hot water extraction to improve the digestion and absorption rate and add the functional enhancer which is useful for health, Can be freely manufactured in the form of a powder, so that it can be easily taken by anyone. On the other hand, since the herbal powder has a high water absorbing property and a strong binding property, it is liable to absorb massive water to form a lump with high binding force. There is a problem that the ingestion effect is low because the disintegration time is prolonged and the digestion can not be performed yet.

The problem to be solved by the present invention is to provide a method for producing a herbal composition which comprises extracting and containing the herbal ingredient in a ring by simple manipulation while preventing the herbal ingredient from being lost or decomposed, The present invention provides a method for manufacturing a pine containing a herbal material extract which reduces the irritation of the herbal composition and allows the herbal ingredient to absorb more of the herbal ingredient.

In order to solve the above-mentioned problems, the present invention provides a method for manufacturing a beverage, Crushing the dried material to extract hot water; Filtering the extracted hot water extract to obtain a filtrate; 10 to 50 parts by weight of a sugar solution is mixed with 100 parts by weight of the filtrate and fermented; Heating and drying the fermented filtrate; And a step of preparing a ring with the dried filtrate. The present invention also provides a method for manufacturing a ring containing a herbal material extract.

At this time, the pulverization is performed by pulverizing the dried material to a size of 5 to 20 mesh, the fermentation is performed at 25 to 45 ° C, and the heating is preferably performed at 90 to 100 ° C for 30 to 60 seconds.

In addition, the hot water extraction is preferably carried out by pouring water into the pulverized dried product and heating it at 75 to 115 ° C. for 5 to 10 hours in a sealed state, and more preferably the water is desalted deep seawater.

Further, the pulverized dried product is roasted at 90 to 110 ° C for 1 to 3 minutes or roasted at 60 to 80 ° C for 3 to 5 minutes, followed by hot water extraction. The steam generated in the hot water extraction step is liquefied and mixed with the filtrate .

In addition, the sugar solution is at least one selected from the group consisting of sugar, oligosaccharide, millet, and dextrin, and it is preferable that the surface of the produced ring is coated with a flour.

The present invention also provides a ring containing a herbal material extract prepared by the above method.

Since the fractions containing the herbal material extract prepared by the method according to the present invention are inhibited from being lost or decomposed in the process of extracting useful components of oriental herbal ingredients, the contents of useful ingredients of herbal ingredients are high, And the extraction process is simple, so that the manufacturing cost is low.

In addition, since it is coated with the corn flour, it can be easily carried and ingested, and the disintegration time is shortened, so that it can be disintegrated promptly after ingestion, so that the human body oil ingredient contained in the herbal material can be sufficiently absorbed from above, It is suppressed, so the weakness of weak stomach, pediatric, and elderly people are reduced.

Hereinafter, a method for producing pills containing the herbal material extract according to the present invention will be described in detail.

Generally, Korean medicine refers to a drug in the form of a hot medicine, which is prepared as a herbal medicine ingredient for the purpose of treatment or prevention of a disease. In general, a medicine (medicine) ingredient liquid medicine ).

In recent years, a packaging container called a retort pouch has been introduced, which can be used to laminate a plastic film or an aluminum foil to a single layer or a multilayer (for example, laminating, and sealed with a herbal medicine, and then pressurized and sterilized at a high temperature.

However, it is also bulky because it is inconvenient to store and carry and it is easy to shed when it is taken, and it is often avoided to take herbal medicine because of the characteristic smell of liquid medicine.

Accordingly, recently, the herbal medicine is produced in the form of a solid pill to minimize the smell and to facilitate storage and drinking. The most common method for this is to crush the oriental herb and then add the appropriate excipient ) Is added to form a granular form.

The excipient serves both as a binder that allows the powder lacking in viscosity to be aggregated in the form of granules, and as a diluting function to control the concentration. Thus, the plant herbal material is simply pulverized and then mixed with an excipient, There is a disadvantage in that the absorption rate of the human body is lowered because a large amount of indigestible substances such as lignin and cellulose of a herbal medicine are contained in the ring.

The lignin and cellulose are the main components of the plant body and cell wall, which are difficult to digest in the human body and occupy 20-30% and 60-70% of the plant dry weight (dry weight), respectively. Since the rate of absorption of the human body is very low, it takes a great deal of money to process it in the form of a ring as compared with the liquid phase, but its efficacy is low and its utility is low.

Therefore, in the present invention, by extracting the herbal material by hot water extraction, the oily material contained in the herbal material is removed by the ring, thereby increasing the human body absorption rate.

First, isoflavone is mixed with the herbal ingredients such as 칡, Hashuo, and Daejeon Daebol-tang material and dried. It is preferable that the drying is sufficiently performed in a well-ventilated shade.

It uses roots and has the most moisture, followed by various nutrients including carbohydrates, minerals, and vitamin C. Especially, it contains daidzin, daidzein, puerarin, It contains isoflavone glycosides and is effective for hangover detoxification, gastrointestinal and hepatoprotective, dyspepsia, asthma, fever, diarrhea, constipation, diabetes and fatigue recovery.

Hashuo is the root of the shrubs and contains anthraquinoids such as chrysophanol, emodin, rhein, physcion, and chrysophanol anthron. It has a lot of starch, fat, lecithine, etc. It has revitalization, enhancement of kidney and liver function, and strong action. It has anemia, nervous breakdown, chronic disease, hemorrhoids with fatigue and hemorrhage, , Arthritis, and arthrosclerosis, constipation, prevention of arteriosclerosis and circulation to promote the action of neuralgia, hyperlipidemia, is effective in strengthening the brain, replenish the blood, and detoxification and is effective in the action.

It is prepared by mixing ginseng, Baekwol, Baekbokryeong, licorice, Seokjipwang, Baekjaepak, Seokguk, Angelicae, Hwanggi, and broiler at the same weight ratio and adding jujube and ginger as necessary. Immunity And red blood cells to eliminate anemia, promotes blood circulation, nourishes the cells to supply nutrients and improves the weakness of the structure shows the effect of chronic amyotrophic disease and recovery after recovery or after surgery to use It is widely used for gynecological diseases, interstitial diseases, surgical and skin diseases, eye irritable diseases, cardiovascular diseases, exercise machine diseases, neonatal diseases and non-geriatric diseases due to its high frequency.

Isoflavones contain 97% glycosides and 3% non-glycosides. Glycosides are present in the form of genistin, daidzin, glycitin, etc. And non-glycosides are composed of genistein, daidzein, glycitein, and other derivatives, and the isoflavone glycosides present in non-fermented foods are more effective than isoflavones present in fermented foods Non-glycosides are known to be very good in terms of bioavailability.

The glycosides of soybean fermented foods are hydrolyzed by the microbial β-glucosidase and converted into non-glycosylated forms that are easily absorbed into the body. The non-glycosylated genistein exhibits excellent anticancer effects such as prostate cancer, breast cancer And it is known that estrogen is similar to female hormone, and thus it is known to be effective for prevention and inhibition of osteoporosis in postmenopausal women.

However, since soy isoflavones present in soybean are present as glycosides of genistin, daidzin and glycitin, there is a problem of low absorption rate in the body. In order to improve the absorption of soy isoflavones, absorption by the microorganisms through fermentation It is preferred to convert isoflavones in an easily non-glycosylated form.

Next, the herbal material containing the dried isoflavone is pulverized and subjected to hydrothermal extraction. The pulverization is carried out in order to facilitate the extraction of the useful component and the separation of the herbal material solids and the extract in the subsequent filtration step A size of 5 to 20 mesh is preferred.

The hot water extraction is carried out by pouring water as an extraction solvent into the pulverized herbal material and heating it in a sealed state at a temperature of 75 to 115 ° C for 5 to 10 hours so that the human oil component contained in the herbal material is discharged into the water.

Desalinated deep sea water is preferably used as the extraction solvent instead of water. Deep sea water is generally water obtained from the ocean of 300 m or more in depth and shows weak alkalinity, usually pH 7.5 to 8.0, though it varies depending on the water intake area.

In deep waters where sunlight does not reach, there is no phytoplankton that consumes nutrients and photosynthesis does not occur. Deep sea water taken from deep water is rich in inorganic nutrients such as nitrogen, phosphorus and silicic acid necessary for plant growth, , Potassium, and sodium, and trace elements such as zinc, selenium, and manganese.

In addition, there is no contamination by air or influent, and the number of viable bacteria is not more than that of surface water, and the bacteria are not contaminated. Therefore, it has better cleanliness than surface water or groundwater. .

Animal cells are most likely to survive in an alkaline environment with a pH of 7.35-7.45, whereas plant cells are known to prefer acidic environments. However, in modern daily life, carbonated beverages are frequently encountered, And risk of bone loss, and in such an acidic environment, some cells become more likely to become cancer cells that flourish in an acidic environment through the adaptation of an internal change process.

Therefore, when a weakly alkaline desalination deep sea water is used as an extraction solvent, the pH of the extract is weakly alkaline to prevent acidification of the human body, and mineral components contained in the deep sea water can supplement bone loss. .

Since the herbal material is generally a plant material strong in fragrance and the fragrant ingredient contains a lot of ingredients useful for the human body, it is necessary to prevent the volatile fragrance ingredient of the herbal ingredient from being lost to the outside during the hot water extraction.

For this purpose, hot water extraction of herbal materials is carried out in the sealed state as described above. Depending on the kind of herbal ingredients, fragrant ingredients may give off a strong smell, It is preferable to discharge the steam steam to remove steam.

In order to further refine the fragrance ingredient of the herbal ingredients, the ground herbal ingredients may be roasted before hot water extraction. Said roasting is roasted at 90 to 110 ° C for 1 to 3 minutes or at 60 to 80 ° C for 3 to 5 minutes It is desirable to give.

As described above, it is roasted at a high temperature for a short time or at a low temperature to purify a strong fragrance component while preventing an oil component of the herbal material from being destroyed by heat.

Generally, the fragrance component of the plant is vaporized together with steam at the time of hot water extraction, and the degree of preference according to the intensity of the fragrance component may vary depending on the taste of the user. Therefore, the steam is liquefied through a distillation apparatus, In an appropriate ratio.

The distillation apparatus for performing the distillation may comprise a body for containing the hot water extract of the herbal material, a heating means for the lower part of the body, and a lid for sealingly engaging with the upper end of the body. And the lid and the collecting container are connected to each other so as to be able to communicate with each other through the pipe, and a cooling means is installed in the middle of the pipe.

It is preferable that the pipe is made of a material having a high thermal conductivity so that the vapor introduced from the lid is efficiently cooled and condensed in the cooling means, and the cooling means is preferably installed in a capacity capable of sufficiently condensing the introduced vapor.

The hot water extract vapors generated in the main body are discharged to a collecting vessel through a pipe connected to an upper lid, are condensed while passing through the cooling means installed in the middle, and collected in a collecting vessel to obtain a one-component vaporizing liquid.

Since the vapor contains only the volatile fragrance component of the herbal material, the vapor of the herbal material is stronger than that of the herbal material extraction filtrate, which is produced by simply filtering the hot water extract of the herbal material, and the impurity is contained It is clear and transparent.

Next, in the case of obtaining the herbal material filtrate by filtration of the extracted hot water extract and removing the solid matter, and when the vapor of the hot water extract is condensed to obtain the herbal material vaporized liquid, the herbal material filtrate is mixed with the herbal material filtrate, It can be mixed at an appropriate ratio according to the taste of the person.

Next, the sugar solution is mixed with 100 parts by weight of the filtrate, and 10 to 50 parts by weight of the sugar solution is mixed with the filtrate. The sugar solution may be a mixture of one or more kinds of sugars, oligosaccharides, starch syrups, dextrin, It is possible to obtain the effect that the strong taste and flavor of the herbal ingredient contained in the filtrate is refined by fermentation.

In addition, the glycoside of isoflavone is hydrolyzed by fermentation and converted into a non-glycosylated form which is easily absorbed into the body, and the effect of increasing the human absorption rate of isoflavone can be obtained.

The fermentation is preferably performed at a temperature of 25 to 45 ° C, more preferably for 1 to 6 months so that sufficient fermentation can take place, and it is most preferred that the fermentation is stirred at any time during fermentation for smooth fermentation

When the fermentation is completed, it is heated to sterilize the fermentation to prevent further fermentation and then dried to produce a ring. The heating is carried out at a temperature of 90 to 100 ° C. for 30 to 60 seconds to destroy the useful ingredient contained in the herbal material filtrate And the drying is carried out such that the sugar solution mixed in the filtrate is dried to such an extent that a proper amount of water remains so as to perform the role of an excipient, thereby facilitating the circulation.

Because of the high absorption and binding properties of the oriental herbal powder, the disintegration time of the pancake containing the herbal material extract prepared as described above may be prolonged, have.

As a method of complementing this point, it is preferable to coat the surface of the above-prepared ring with a flour, and when the flour coated with the flour is used, the above stimulation by the herbal material is reduced while the ring is mixed with the ring, And the sugar solution is viscous and stably fixes the flour on the surface of the flute, so that the flour is not separated from the flame.

It is a perennial herbaceous perennial plant of Liliaceae. It is an alkaline food which contains high quality protein and mannan as carbohydrates and is rich in various minerals.

The root of the horse contains amylase and other enzymes to help digestion and stimulate insulin secretion, thus helping to prevent and cure diabetes. In the private sector, there is a research result that suggests that ingestion of nutrients to relieve hangovers, fatigue, blood pressure, And in one room, it is used for tonic, gangjeongje, and jiji.

The above-mentioned margarine is coated on the surface of the ring in powder form in which the raw root of the digger is dried and pulverized. When the ring reaches above, the strong pharmacological ingredient of the herbal material first alleviates the rapid stimulation on the stomach wall, and then the amylase enzyme The sugar of the sugar solution contained in the ring is hydrolyzed to accelerate the decomposition of the ring, so that the ring is rapidly disintegrated from above, so that the usable ingredient of the herbal material can be absorbed into the gastric wall.

In general, the ingestion of the ring does not chew in the mouth, but it is swallowed with the water as it is. Therefore, the amylase, which is a polysaccharide degrading enzyme contained in the needles, is not mixed and the digestibility of the sugar solution contained in the ring is lowered. However, And can be quickly absorbed by the human body.

In addition, when the food is ingested, gastric juice from the stomach is secreted from the stomach, and stomach acid in the gastric juice stimulates the stomach. Since the stomach is alkaline, the stimulation is also reduced.

As a method for further reducing the irritation on the top, there is a method of controlling the coating thickness of the corn flour. When the amount of the sugar solution to be mixed in the filtrate is mixed within the above range, The coating thickness is evenly distributed from thin to thick.

When ingesting a ring containing a herbal material extract having various coating thicknesses, the pharmacological component of the herbal material stimulates the stomach wall, while the pellet of the herbal material is completely dissolved, It is dissolved while moving to the small intestine, so that it is possible to prevent irritation on the upper part, thereby reducing temporal irritation on the upper part.

There is no particular limitation on the method of drying the hemp for producing the flour, but a freeze-drying method is preferable in order to quickly dissolve the hemp.

When the margarine is lyophilized and crushed, the porosity of the margarine increases and the porosity thereof increases, so that the absorption of moisture from the margarine is accelerated so that it dissolves rapidly and promotes the digestion of the ring.

As described above, by adding sugar solution, oligosaccharide, starch syrup, and dextrin sugar solution as a main component, the pharmacological ingredients contained in the herbal ingredients reduce irritation of the stomach, and by coating the surface of the ring with the corn flour, The effect of protecting the stomach can be obtained.

Although the method of manufacturing the ring has been described above, the present invention is not limited to the ring-shaped form, but includes the form of granules and tablets as the form of the ring, so that it is also obvious that the present invention belongs to the category of the present invention.

Hereinafter, the present invention will be described in more detail with reference to the following examples, comparative examples and test examples.

It should be noted, however, that the following examples are for illustrative purposes only and are not intended to limit the scope of the present invention. The present invention is not limited to the following examples. Will be apparent to those skilled in the art to which the present invention pertains.

≪ Example 1 >

100 g of roots (100 g), 100 g of roots (roots), 100 g of Daejeon Daebeungbotang (ginseng, Baekwolryeong, licorice, 100 g of flavone were mixed and thoroughly dried for 10 days in well-ventilated shade, and then pulverized to a size of 10 mesh using a coarse grinder.

300 g of the pulverized mixed material and 3 L of purified water were placed in a heating vessel, sealed, boiled for 7 hours, and subjected to hot water extraction.

10 g of the sugar solution mixed with sugar, oligosaccharide, syrup and dextrin in the same weight ratio was added to 30 g of the filtrate from which the solid matter was removed, And fermented at 35 DEG C for 3 months with intermittent stirring.

After the fermentation was completed, the mixture was heated at 95 ° C for 45 seconds. The mixture was naturally dried until a slight amount of moisture remained, and then kneaded with a ventilator to prepare a ring containing the herbal material extract.

≪ Example 2 >

In Example 1, a ring was prepared in the same manner as in Example 1 except that deionized deep-sea water instead of purified water was used.

≪ Example 3 >

In Example 1, a ring was prepared in the same manner as in Example 1, except that the pulverized mixed material was roasted at 70 캜 for 4 minutes and then subjected to hot water extraction.

<Example 4>

In the first embodiment, the heating vessel is provided with heating means in the lower part of the main body for containing the pulverized mixed material and purified water, and a lid is hermetically fastened to the upper part of the main body. One end of a copper pipe having a diameter of 1.5 cm And the other end of the copper pipe is connected to the collecting container, and the lid and the collecting container are connected to each other through a pipe.

The copper pipe was 7 m in length and was installed so as to be submerged in a cooling water tank through which cold water flows, and the copper pipe was allowed to flow downward from the lid toward the collection vessel.

The main body was heated by a heating means so that the steam generated therein was passed through the copper pipe and condensed by the cold water of the cooling water pipe while passing through the copper pipe to collect in the collecting container.

A condensation liquid collected in the collection vessel was mixed with the filtrate, and a ring was prepared in the same manner as in Example 1 except for that.

&Lt; Example 5 >

The sample was frozen at -25 ° C, heated with a hot plate at 50 ° C to be dried, and pulverized to obtain a granulate. The granules prepared in Example 1 were thoroughly coated with the granules, Was poured off to prepare a ring coated with the surface of the flour.

&Lt; Comparative Example 1 &

In Example 1, a ring was prepared in the same manner as in Example 1, except that the pulverized mixed material was fermented as it was without mixing with hot water.

&Lt; Comparative Example 2 &

In Example 1, a ring was prepared in the same manner as in Example 1, except that the filtrate and the sugar solution mixture were dried without being fermented and heated to produce a ring.

&Lt; Test Example 1 > Analysis of content of herbal ingredients

The absorbance of the rings containing the herbal material extract prepared in Examples 1 to 4 and Comparative Examples 1 and 2 was measured at 675 nm using a spectrophotometer (UV-1601PC, Shimadzu Corp., Japan) Respectively.

In the case of Example 5, the same as in Example 1 except for the particulate matter was excluded from the measurement.

Absorbance measurement result Absorbance Example 1 0.36 Example 2 0.37 Example 3 0.33 Example 4 0.42 Comparative Example 1 0.29 Comparative Example 2 0.38

The results of Table 1 show that the example 4 in which the vaporized liquid having the distillation device cooled and condensed with the filtrate was mixed with the filtrate showed the highest value and it was found that the steam was condensed and recovered in the hot water extraction, It can be seen that a larger amount of material components are contained.

On the other hand, in Comparative Example 1 in which the pulverized mixed material was fermented by mixing with the sugar solution without hot water extraction, the lowest absorbance was obtained because the content of lignin and cellulose in the mixed material was relatively high, .

In Comparative Example 2, in which the dried product was roasted in Example 3 and the filtrate and the sugar solution were dried without being fermented and heated, the fragrance ingredient was partially removed in the process of frying or fermenting the herbal ingredients. .

&Lt; Test Example 2 >

The rings prepared in the above Examples and Comparative Examples were allowed to stand in contact with air in a humid environment of hot and humid air, and then the day when discoloration or alteration was first detected by visual observation was regarded as the date of occurrence of decay, .

Observation date of corruption Corruption occurrence day (days) Example 1 7.8 Example 2 9.6 Example 3 8.4 Example 4 7.3 Example 5 12.2 Comparative Example 1 5.6 Comparative Example 2 5.1

As shown in Table 2, in Example 5 in which the surface of the ring was coated with a flour, the Comparative Example 2, which was the most late decayed and the non-fermented, showed the earliest corruption. From this, It is preferable to heat or sterilize the material by fermenting the material or by coating the material with a corn flour.

Also, in Comparative Example 1, corruption proceeded rapidly because lignin and cellulose contained in the ring were found to decay more rapidly than the water-soluble components of herbal materials.

In addition, corruption occurred later in Example 2 using deionized deionized water instead of purified water. From these results, it was found that the use of deep-sea water as a hot water extraction solvent without phytoplankton, It can be seen that there is an effect to improve.

&Lt; Test Example 3 > A crumbling test

The rings of the above Examples and Comparative Examples were subjected to disintegration tests in accordance with the Health Functional Food Standard I.3, Common Standard (3), and III.2.1 Disintegration Test Method.

The conformance to the disintegration test standard and the time at which the disintegration time of the disintegration was visually observed are shown in Table 3 below.

Disintegration test result Disintegration test standard
Suitability Disintegration time (minutes) Example 1 fitness 16 Example 2 fitness 17 Example 3 fitness 14 Example 4 fitness 19 Example 5 fitness 12 Comparative Example 1 fitness 8 Comparative Example 2 incongruity -

In the results of Table 3, the Example according to the present invention and Comparative Example 1 were all disintegrated during the first solution test in the disintegration test of the health functional food pesticide. In the case of Comparative Example 2, however, It is not disintegrated and it is found to be unsuitable as a ring.

In addition, Example 5 coated with the flour showed a shorter disintegration time than Example 1 coated with no flour, indicating that the coating of the flour promotes disintegration of the flute.

In general, the time for the food to stay on is about 0.5 to 6 hours, and the ring of the example according to the present invention disintegrates within 20 minutes, so that the ring of the present invention disintegrates at the time of ingestion so that the oil component contained in the herbal material is sufficiently absorbed It will provide time for

The disintegration time of Comparative Example 1 in which hot water was not extracted was the shortest, which is presumed to be because the lignin and cellulose contained in the ring lower the binding force of the ring.

&Lt; Test Example 4 >

The flavor, taste, degree of irritation and overall acceptability of the pellets prepared in the above Examples and Comparative Examples were measured by a five-point scale method, and the average value of the pellets prepared in the above Examples and Comparative Examples was measured in the following Table Respectively.

Sensory test result incense flavor Stimulus from above Overall likelihood Example 1 3.5 3.3 3.7 3.5 Example 2 3.6 3.5 3.7 3.6 Example 3 4.1 3.9 4.1 4.0 Example 4 4.3 3.2 3.2 3.8 Example 5 3.0 4.3 4.4 4.2 Comparative Example 1 3.3 3.1 3.4 3.2 Comparative Example 2 2.7 2.2 2.5 2.5  5: very good, 4: good, 3: normal, 2: poor, 1: very poor

From the result of the evaluation of the flavor shown in Table 4, the highest value of Example 4 was obtained and the lowest value of Comparative Example 2 was obtained. When the vaporized liquid cooled and condensed with steam was mixed with the filtrate, It is considered that the strong fragrance of oriental herbal ingredients is not refined and causes a sense of rejection.

As a whole, the taste was evaluated as superior to the comparative example as a whole, the comparative example 2 was evaluated as the lowest, and the bitterness of the comparative example 2 was evaluated as too strong.

In the above evaluation of the irritation, Example 5 in which the ring was coated with the corn flour was the most excellent, and Example 3 in which the mixed material was roasted was evaluated favorably, so that the corn flour relaxed the above stimuli, roasted the mixed material, It can be seen that the weakness of the material is refined to reduce the irritation from above.

In addition, since the higher the sugar content is, the longer the time to feel the stimulus after taking the drug is, the more delayed detection is possible. Therefore, when multiple rings are taken at the same time, do.

The overall preference was evaluated in the order of Example 5> Example 3> Example 4> Example 2> Example 1> Comparative Example 1> Comparative Example 2 to confirm the merchantability of the pills containing the herbal material extract according to the present invention I could.

As can be seen from the above, since the fractions containing the herbal material extract prepared by the method of the present invention are inhibited from being lost or decomposed in the process of extracting useful components of herbal materials, the contents of useful ingredients of herbal materials are high, It can be stored for a long time due to the delay of corruption and the extraction process is simple, so that the manufacturing cost is reduced.

In addition, since it is coated with the corn flour, it can be easily carried and ingested, and the disintegration time is shortened, so that it can be disintegrated promptly after ingestion, so that the human body oil ingredient contained in the herbal material can be sufficiently absorbed from above, It is suppressed, so the weakness of weak stomach, pediatric, and elderly people are reduced.

Claims (11)

Mixing, drying, mixing, and drying the mixture;
Crushing the dried material to extract hot water;
Filtering the extracted hot water extract to obtain a filtrate;
10 to 50 parts by weight of a sugar solution is mixed with 100 parts by weight of the filtrate and fermented;
Heating and drying the fermented filtrate; And
And a step of preparing a ring with the dried filtrate. The method according to claim 1,
Wherein the pulverization is carried out by pulverizing the dried material to a size of 5 to 20 mesh. The method according to claim 1,
Wherein the hot water extraction is carried out by pouring water into the pulverized dried product and heating it in a sealed state at a temperature of 75 to 115 DEG C for 5 to 10 hours. The method of claim 3,
Wherein the water is a desalted deep sea water. The method according to claim 1,
Wherein the pulverized dried product is roasted at 90 to 110 ° C for 1 to 3 minutes or roasted at 60 to 80 ° C for 3 to 5 minutes and then subjected to hot water extraction. The method according to claim 1,
Wherein the steam generated in the hot water extraction step is liquefied and mixed with the filtrate. The method according to claim 1,
Wherein the sugar solution is at least one selected from the group consisting of sugar, oligosaccharide, syrup, and dextrin. The method according to claim 1,
Wherein the fermentation is carried out at 25 to &lt; RTI ID = 0.0 &gt; 45 C. &lt; / RTI &gt; The method according to claim 1,
Wherein the heating is carried out at 90 to 100 占 폚 for 30 to 60 seconds. The method according to claim 1,
A method of manufacturing a pie containing a herbal material extract, characterized in that the surface of the prepared pie is coated with a flour. A process for the preparation of a medicament containing a herbal material extract, which is produced by the method of any one of claims 1 to 10.