KR20140078656A - 증식성 질환의 치료를 위한 hsp90 억제제와 조합된 2-카르복스아미드 시클로아미노 우레아 유도체 - Google Patents

증식성 질환의 치료를 위한 hsp90 억제제와 조합된 2-카르복스아미드 시클로아미노 우레아 유도체 Download PDF

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KR20140078656A
KR20140078656A KR1020147009376A KR20147009376A KR20140078656A KR 20140078656 A KR20140078656 A KR 20140078656A KR 1020147009376 A KR1020147009376 A KR 1020147009376A KR 20147009376 A KR20147009376 A KR 20147009376A KR 20140078656 A KR20140078656 A KR 20140078656A
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cancer
compound
alkyl
pharmaceutically acceptable
combination
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Korean (ko)
Inventor
시종 후앙
코넬리아 쿠아트
후이-친 왕
크리스틴 프리치
크리스티앙 르네 슈넬
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노파르티스 아게
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020147009376A 2011-10-14 2012-10-11 증식성 질환의 치료를 위한 hsp90 억제제와 조합된 2-카르복스아미드 시클로아미노 우레아 유도체 Ceased KR20140078656A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161547308P 2011-10-14 2011-10-14
US61/547,308 2011-10-14
PCT/EP2012/070171 WO2013053833A1 (en) 2011-10-14 2012-10-11 2 - carboxamide cycloamino urea derivatives in combination with hsp90 inhibitors for the treatment of proliferative diseases

Publications (1)

Publication Number Publication Date
KR20140078656A true KR20140078656A (ko) 2014-06-25

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KR1020147009376A Ceased KR20140078656A (ko) 2011-10-14 2012-10-11 증식성 질환의 치료를 위한 hsp90 억제제와 조합된 2-카르복스아미드 시클로아미노 우레아 유도체

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Country Link
US (2) US20140275089A1 (enExample)
EP (1) EP2766015A1 (enExample)
JP (2) JP6180420B2 (enExample)
KR (1) KR20140078656A (enExample)
CN (2) CN103857392A (enExample)
AU (1) AU2012322976B2 (enExample)
BR (1) BR112014008400A2 (enExample)
CA (1) CA2851383A1 (enExample)
MX (1) MX2014004559A (enExample)
RU (2) RU2624493C2 (enExample)
WO (1) WO2013053833A1 (enExample)

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AU2012331125A1 (en) * 2011-11-02 2014-05-22 Novartis Ag 2-carboxamide cycloamino urea derivatives for use in treating VEGF - dependent diseases
MX2019009552A (es) 2017-02-17 2019-10-02 Hutchinson Fred Cancer Res Terapias de combinacion para el tratamiento de canceres relacionados con el antigeno de maduracion de celulas b (bcma) y trastornos autoinmunitarios.
CN111214473B (zh) * 2020-02-14 2022-02-01 中国人民解放军陆军军医大学 Hsp990在制备抗轮状病毒药物中的应用
TW202508595A (zh) 2023-05-04 2025-03-01 美商銳新醫藥公司 用於ｒａｓ相關疾病或病症之組合療法
US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
AU2024360465A1 (en) 2023-10-12 2026-04-09 Revolution Medicines, Inc. Macrocyclic ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
TW202547461A (zh) 2024-05-17 2025-12-16 美商銳新醫藥公司 Ｒａｓ抑制劑
WO2025255438A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer

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US4261989A (en) 1979-02-19 1981-04-14 Kaken Chemical Co. Ltd. Geldanamycin derivatives and antitumor drug
SI1611112T1 (sl) 2003-02-11 2012-12-31 Vernalis (R&D) Limited Izoksazolne spojine kot inhibitorji vroäśinskih ĺ ok proteinov
JO2783B1 (en) 2005-09-30 2014-03-15 نوفارتيس ايه جي Compounds 2-Amino-7, 8-dihydro-6H-Bayredo (3,4-D) Pyrimidine-5-Ones
PL2182948T3 (pl) * 2007-07-24 2013-07-31 Novartis Ag Zastosowanie imidazochinolin do leczenia chorób EGFR-zależnych albo chorób wykazujących nabytą oporność wobec środków ukierunkowanych na członków rodziny EGFR
TW200922595A (en) * 2007-10-12 2009-06-01 Novartis Ag Organic compounds
UA104147C2 (uk) * 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
BRPI0924107A2 (pt) * 2008-11-28 2019-09-24 Novartis Ag inibidores de hsp90 para tratamento terapêutico
DE102009012631B4 (de) 2009-03-11 2011-07-28 Bayer Schering Pharma Aktiengesellschaft, 13353 Filter für einen Computertomographen sowie Computertomograph
MX360157B (es) * 2010-11-08 2018-10-24 Novartis Ag Uso de derivados de 2-carboxamida-cicloamino-urea en el tratamiento de enfermedades dependientes de egfr o de enfermedades que han adquirido resistencia a los agentes que tienen como objetivo los miembros de la familia egfr.

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RU2017119219A (ru) 2018-11-02
AU2012322976A1 (en) 2014-05-01
US20160199365A1 (en) 2016-07-14
CN103857392A (zh) 2014-06-11
US20140275089A1 (en) 2014-09-18
EP2766015A1 (en) 2014-08-20
JP6180420B2 (ja) 2017-08-16
JP2014528464A (ja) 2014-10-27
CA2851383A1 (en) 2013-04-18
RU2017119219A3 (enExample) 2018-11-02
AU2012322976B2 (en) 2016-05-12
RU2624493C2 (ru) 2017-07-04
JP2017214387A (ja) 2017-12-07
MX2014004559A (es) 2014-08-01
CN106474127A (zh) 2017-03-08
WO2013053833A1 (en) 2013-04-18
RU2014119339A (ru) 2015-11-20
BR112014008400A2 (pt) 2017-04-04

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