CA2851383A1 - 2 - carboxamide cycloamino urea derivatives in combination with hsp90 inhibitors for the treatment of proliferative diseases - Google Patents
2 - carboxamide cycloamino urea derivatives in combination with hsp90 inhibitors for the treatment of proliferative diseases Download PDFInfo
- Publication number
- CA2851383A1 CA2851383A1 CA2851383A CA2851383A CA2851383A1 CA 2851383 A1 CA2851383 A1 CA 2851383A1 CA 2851383 A CA2851383 A CA 2851383A CA 2851383 A CA2851383 A CA 2851383A CA 2851383 A1 CA2851383 A1 CA 2851383A1
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- Prior art keywords
- compound
- alkyl
- pharmaceutically acceptable
- combination
- substituted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161547308P | 2011-10-14 | 2011-10-14 | |
| US61/547,308 | 2011-10-14 | ||
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| MX2014005414A (es) * | 2011-11-02 | 2014-09-22 | Novartis Ag | Derivados de 2-carboxamida-cicloamino-urea para su uso en el tratamiento de las enfermedades dependientes del factor de crecimiento endotelial vascular (vegf). |
| IL268349B2 (en) | 2017-02-17 | 2024-08-01 | Hutchinson Fred Cancer Res | Combination therapies for treatment of bcma-related cancers and autoimmune disorders |
| CN111214473B (zh) * | 2020-02-14 | 2022-02-01 | 中国人民解放军陆军军医大学 | Hsp990在制备抗轮状病毒药物中的应用 |
| KR20260019479A (ko) | 2023-05-04 | 2026-02-10 | 레볼루션 메디슨즈, 인크. | Ras 관련 질환 또는 장애를 위한 병용 요법 |
| CN121889155A (zh) | 2023-08-07 | 2026-04-17 | 锐新医药公司 | 用于治疗ras蛋白相关疾病或病症的rmc-6291 |
| AU2024360465A1 (en) | 2023-10-12 | 2026-04-09 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
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| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
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| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
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| US4261989A (en) | 1979-02-19 | 1981-04-14 | Kaken Chemical Co. Ltd. | Geldanamycin derivatives and antitumor drug |
| KR101166749B1 (ko) | 2003-02-11 | 2012-07-27 | 베르날리스(캠브리지)리미티드 | 열쇼크 단백질 저해제로서의 이소옥사졸 화합물 |
| JO2783B1 (en) | 2005-09-30 | 2014-03-15 | نوفارتيس ايه جي | Compounds 2-Amino-7, 8-dihydro-6H-Bayredo (3,4-D) Pyrimidine-5-Ones |
| WO2009013305A1 (en) * | 2007-07-24 | 2009-01-29 | Novartis Ag | Use of imidazoquinolines for the treatment of egfr dependent diseases or diseases that have acquired resistance to agents that target egfr family members |
| TW200922595A (en) * | 2007-10-12 | 2009-06-01 | Novartis Ag | Organic compounds |
| UA104147C2 (uk) | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
| US20110230499A1 (en) * | 2008-11-28 | 2011-09-22 | Novartis Ag | Hsp90 inhibitors for therapeutic treatment |
| DE102009012631B4 (de) | 2009-03-11 | 2011-07-28 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Filter für einen Computertomographen sowie Computertomograph |
| BR112013009624A2 (pt) * | 2010-11-08 | 2016-07-12 | Novartis Ag | uso de derivados de 2-carboxamida cicloamino ureia no tratamento de doenças dependemtes de egfr pu doenças que tenham adquirido resistência a agentes que tenham como alvo membros da família egfr |
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Also Published As
| Publication number | Publication date |
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| WO2013053833A1 (en) | 2013-04-18 |
| KR20140078656A (ko) | 2014-06-25 |
| JP2017214387A (ja) | 2017-12-07 |
| EP2766015A1 (en) | 2014-08-20 |
| RU2017119219A3 (enExample) | 2018-11-02 |
| US20160199365A1 (en) | 2016-07-14 |
| US20140275089A1 (en) | 2014-09-18 |
| RU2624493C2 (ru) | 2017-07-04 |
| BR112014008400A2 (pt) | 2017-04-04 |
| JP2014528464A (ja) | 2014-10-27 |
| RU2017119219A (ru) | 2018-11-02 |
| AU2012322976A1 (en) | 2014-05-01 |
| MX2014004559A (es) | 2014-08-01 |
| JP6180420B2 (ja) | 2017-08-16 |
| AU2012322976B2 (en) | 2016-05-12 |
| CN103857392A (zh) | 2014-06-11 |
| CN106474127A (zh) | 2017-03-08 |
| RU2014119339A (ru) | 2015-11-20 |
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