KR20140068437A - Spuit - Google Patents
Spuit Download PDFInfo
- Publication number
- KR20140068437A KR20140068437A KR20120135927A KR20120135927A KR20140068437A KR 20140068437 A KR20140068437 A KR 20140068437A KR 20120135927 A KR20120135927 A KR 20120135927A KR 20120135927 A KR20120135927 A KR 20120135927A KR 20140068437 A KR20140068437 A KR 20140068437A
- Authority
- KR
- South Korea
- Prior art keywords
- inflow pipe
- ball
- syringe
- cap
- blood
- Prior art date
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Images
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0275—Interchangeable or disposable dispensing tips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/16—Reagents, handling or storing thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
- B01L3/0213—Accessories for glass pipettes; Gun-type pipettes, e.g. safety devices, pumps
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
Description
The present invention relates to a syringe having a structure and components for solution mixing. More specifically, the present invention relates to a syringe having a boronic acid latex ball in an inlet tube and a through hole in a cap portion, The present invention relates to a syringe capable of performing a pretreatment process of mixing a blood sample, a buffer solution and a boronic acid latex ball when measuring glycated hemoglobin (HbA1c).
Glycated hemoglobin (HbA1c) is a type of hemoglobin used to detect blood glucose (blood sugar) concentration over a long period of time, and it reflects the recent 2 to 3 month blood glucose level. The glycated hemoglobin can be detected by the blood test. It can be used to determine whether the diabetic control is performed well at the time of follow-up.
In the conventional measurement of glycation hemoglobin, the collected blood is put into a reaction reagent, mixed well and allowed to stand for 2 minutes. The reaction solution mixture in which the reagent and blood have reacted is dispensed into a test strip and the washing solution (buffer solution) Then, the test strip is attached to the saccharide blood measuring device and analyzed.
FIG. 1 is an example of a conventional pretreatment apparatus for measuring saccharification blood, and FIG. 2 is a state of use of a pretreatment apparatus for measuring saccharification blood of FIG.
FIG. 1 shows a conventional apparatus for measuring saccharified blood, which comprises a
That is, the process of dispensing the collected blood to the test strip by mixing the reagent solution and the buffer solution well mixed with each other is cumbersome and complicated. In addition, two pipettes (for 200ul and 5ul) and a pipette tip for each pipette were required, and it was troublesome to insert and pull the pipette tip into and out of the pipette, and to open and close the lid of the buffer vessel. Therefore, a device for a simplified process is required.
To this end, the present invention proposes an eyedropper having a built-in eyedrop latex ball and capable of performing pipetting and mixing. The syringe of the present invention can be subjected to a pretreatment process in which the buffer and the buffer solution are mixed well with the reaction reagent in the blood as a single device.
SUMMARY OF THE INVENTION It is an object of the present invention to provide a method for measuring hemoglobin (HbA1c), which comprises a Boronic Acid Latex Ball and a tip integrally therewith, The present invention provides a syringe capable of performing a pretreatment process of mixing a boronic acid latex ball.
Another problem to be solved by the present invention is to provide a cap structure that has a tube structure for sucking a predetermined amount of blood samples by capillary phenomenon and has a through hole on both sides of the
Another problem to be solved by the present invention is to provide a syringe which has been subjected to a hydrophilic treatment so that the inside of the tip portion of the syringe sucks blood well, and to which heparin treatment is applied to prevent the blood from being sucked.
Another object of the present invention is to provide a syringe having a structure and components for solution mixing.
Another problem to be addressed by the present invention is the incorporation of a bronze latex ball which is adapted to be mixed with a 200 ul buffer and a 5 ul blood sample with a syringe having a ring to prevent the bronze latex ball from moving to the top of the syringe .
According to an aspect of the present invention, there is provided an eyedropper having a cap portion made of an elastic material coupled to an upper end of an inflow tube portion through which a solution flows, the eyedropper having a through hole on one or both sides of the cap portion, A tip portion positioned at a lower end of the inflow tube portion and having a tube structure; A bottom portion of the inflow pipe where the tip portion is inserted, an upper portion of the inflow pipe which is located on the lower portion of the inflow pipe, and which forms a step with the lower portion of the inflow pipe, And a protruding portion formed on the protruding portion.
A latex ball is embedded in the lower portion of the inflow pipe, and a ring for preventing ball movement is fixedly mounted on a bottom portion of the inflow pipe. The latex ball includes bromonic acid.
According to another aspect of the present invention, there is provided an eyedropper having a cap portion made of an elastic material coupled to an upper end of an inflow tube portion through which a solution flows, the inflow tube portion including: a tip portion positioned at a lower end of the inflow tube portion; A lower portion of the inflow pipe into which the tip portion is inserted; And an upper portion of the inflow pipe which is located above the lower portion of the inflow pipe and has a stepped portion with the lower portion of the inflow pipe, wherein a latex ball containing Bronno acid is built in the lower portion of the inflow pipe, And the prevention ring is fixedly mounted.
The lower end of the inflow pipe has a smaller inner diameter as it approaches the tip, and the diameter of the bronze latex ball is larger than the inner diameter of the lower end of the inflow pipe and smaller than the upper inner diameter of the lower portion of the inflow pipe.
Both sides of the cap portion are provided with recesses, and the recesses are located in the recesses.
The inside of the tip portion is subjected to a hydrophilic treatment and a heparin treatment.
The inner diameter of the ball prevention ring is smaller than the diameter of the boronic acid latex ball.
A tongue is provided at a lower portion of a side portion of the ball restraining ring, and the tongue is engaged with a groove provided in an inner lower portion of the upper portion of the inflow pipe.
The cap portion is made of a rubber material, a silicon material, or a PE (plastic) material. The inflow pipe portion is made of a plastic material or a glass material. The ring for preventing ball movement is made of rubber material, silicone material, or PE (plastic) material.
The syringe is for separating glycated hemoglobin. When the syringe is sucked with the syringe and then the buffer solution is mixed with the syringe, the syringe hemoglobin (HbA1c) contained in the blood, Of glucose to separate glycosylated hemoglobin from common non-glycosylated hemoglobin (Hb).
When the blood is sucked into the eyedropper, the opening of the cap part is opened so as to be sucked.
When the buffer solution is put into the syringe and mixed, the syringe containing the blood is placed in a buffer solution tube containing the buffer solution, and the cap part is closed with the through hole of the cap part being closed, whereby blood, A latex ball, and a buffer solution are mixed.
According to the eyedropper of the present invention, a boric acid latex ball is provided and a tip is integrally provided to perform pre-treatment in which 5ul blood sample, 200ul buffer and boronic acid latex ball are mixed with one syringe at the time of measuring glycated hemoglobin (HbA1c) Process can be performed.
In addition, the eyedropper of the present invention has a tubular structure for sucking a predetermined amount of blood sample by capillary phenomenon, and the
In addition, in the eyedropper of the present invention, the inside of the tip portion of the eyedropper is subjected to hydrophilic treatment so as to suck blood well, and heparin treatment is performed so as to prevent the coagulation of the drawn blood, It is made to not be.
Further, the eyedropper of the present invention has a structure and components for solution mixing, is easy to use, economical, and disposable, and is sanitary and safe.
In addition, the syringe of the present invention incorporates a bronze latex ball, which is made to mix with a 200 ul buffer and a 5 ul blood sample, with a ring to prevent the bronze latex ball from moving to the top of the syringe, So that the ball moves to the cap part and does not hamper the pre-processing.
In the conventional pretreatment method, two pipettes (for 200ul and 5ul) and a pipette tip for each pipette were required, and it was troublesome to insert the pipette tip into and out of the pipette and to open and close the buffer vessel lid However, in the present invention, it is possible to perform preprocessing with one eyedropper.
In the present invention, in the pretreatment for the measurement of glycated hemoglobin (% HbA1c), the
Particularly, the eyedropper of the present invention is used in a single use and has an advantage that a user can use the eyedropper conveniently and safely.
In addition, the syringe of the present invention can be used for pretreatment for various diagnostic fields such as Cardiac, Infection, Rheumatoid Arthritis, Hormone, and Cancer as well as a pretreatment process for analyzing HbA1c. Of the tip is not limited to blood, but can also be applied to urine collection, such as the Urine Capillary Tip.
1 is an example of a conventional pretreatment apparatus for measuring saccharide blood.
FIG. 2 is a use state diagram of the pretreatment apparatus for measuring saccharification blood of FIG. 1; FIG.
3 is a perspective view of the eyedropper of the present invention.
Fig. 4 is an explanatory diagram for explaining the inside of the eyedropper of Fig. 3; Fig.
5 is an enlarged view of the cap portion of Fig.
FIG. 6 is an explanatory diagram for explaining a cross section of the cap portion of FIG. 4;
Fig. 7 is an enlarged view of the ball restraining ring of Fig. 4;
Figure 8 is a cross-sectional view of the tip of Figure 4;
9 is a pre-treatment device for measuring glycated hemoglobin using the eyedrop of the present invention.
Fig. 10 is an explanatory view for explaining a method of using the eyedropper of the present invention. Fig.
Hereinafter, the eyedropper of the present invention will be described in detail with reference to the attached drawings.
Fig. 3 is a perspective view of the eyedropper of the present invention, and Fig. 4 is an explanatory view for explaining the inside of the eyedropper of Fig.
The
The
The
The through
The through hole may exist only on one side of the
The circular
The
The
The
In addition, the
The inflow tube
The radius of the boronic
The
In the present invention, boron acid latex balls are exemplified for convenience of explanation, but the present invention is not limited thereto. The main components of the latex balls are not limited to boronic acid and may be changed according to the field to be inspected .
When the
The upper portion of the
A
The inner diameter of the
The upper portion of the
FIG. 5 is an enlarged view of the cap portion of FIG. 4, and FIG. 6 is an explanatory view for explaining a cross section of the cap portion of FIG.
The
Fig. 7 is an enlarged view of the ball restraining ring of Fig. 4;
The inner diameter of the ball
Figure 8 is a cross-sectional view of the tip of Figure 4;
The
The following describes the method of manufacturing the eyedropper of the present invention.
The inside of the
The boron
Next, the
FIG. 9 is a pre-treatment device for measuring glycated hemoglobin using the eyedropper of the present invention, and FIG. 10 is an explanatory view for explaining a method of using the eyedropper of the present invention.
As shown in FIG. 10 (a), 5 ul of blood is taken from the punctured fingertip, and the through
10 (b), the capillary 100 is pressed or uncompressed in a state where the eyedropper is inserted into the
As shown in FIG. 10C, after the entire solution mixed from the buffer solution tube is sucked into the syringe, the solution is slowly dropped to the
In the pretreatment for the measurement of glycated hemoglobin (% HbA1c), 5 l of the blood collected in the eyedropper of the present invention, which is a syringe containing the boronic
In the conventional method, two pipettes (for 200ul and 5ul) and a pipette tip for each pipette were required, and it was troublesome to insert and pull the pipette tip into and out of the pipette, and to open and close the lid of the buffer vessel .
Particularly, the present invention can easily collect blood 5 ul by the
The eyedropper of the present invention is used in a single use, which is advantageous in that the eyedropper can be conveniently and safely used by the user.
Unlike the conventional eyedropper, the eyedropper of the present invention has a tubular structure for sucking a predetermined amount of blood sample into a capillary phenomenon and has a through hole on both sides of the
The eyedropper of the present invention is used in a state in which the through
The inside of the
The
The eyedropper of the present invention incorporates a bronze latex ball, which is configured to be mixed with a 200 ul buffer and a 5 ul blood sample, and has a ring that prevents the bronze latex ball from moving to the top of the eyedropper.
10: Syringe 100: Cap
110: through hole 120: circular recess
200: inlet tube 210: tip
240: inlet pipe bottom 250: boron acid latex balls
270: inlet pipe top 280: ball restraining ring
282: jaw 350: test strip
Claims (16)
And a through hole is provided on both sides or one side of the right and left sides of the cap portion,
The inflow pipe portion
A tip portion positioned at a lower end of the inflow tube portion and having a tube structure;
A lower portion of the inflow pipe into which the tip portion is inserted;
And an upper portion of the inflow pipe located above the inflow pipe, the inflow pipe being stepped with the lower portion of the inflow pipe,
And a protruding portion inserted into the lower portion of the inflow pipe to protrude in the lower portion of the lower portion of the inflow pipe.
A latex ball is embedded in the lower part of the inflow pipe,
And a ball restraining ring is fixedly mounted on a bottom portion of the upper portion of the inflow pipe.
Characterized in that the latex ball comprises brononic acid.
The inflow pipe portion
A tip portion positioned at a lower end of the inflow tube portion and having a tube structure;
A lower portion of the inflow pipe into which the tip portion is inserted;
And an upper portion of the inflow pipe located above the inflow pipe, the inflow pipe being stepped with the lower portion of the inflow pipe,
A latex ball containing brononic acid is embedded in the lower part of the inflow pipe,
And a ball restraining ring is fixedly mounted on a bottom portion of the upper portion of the inflow pipe.
The lower part of the inflow pipe has a smaller inner diameter as it approaches the tip,
Wherein the diameter of the bronze latex ball is larger than the inner diameter of the lower end of the lower portion of the inflow pipe and smaller than the upper inner diameter of the lower portion of the inflow pipe.
The cap portion is provided with recesses on the left and right sides thereof,
And the through hole is positioned in the recess.
And the inside of the tip portion is subjected to a hydrophilic treatment and a heparin treatment.
Wherein the ring for preventing ball movement has an inner diameter smaller than the diameter of the boronic acid latex ball.
And a jaw provided at a lower portion of a side portion of the ball blocking prevention ring, the jaw being engaged with a groove provided in an inner lower portion of the upper portion of the inflow pipe.
Wherein the cap portion is made of a rubber material, a silicone material, or a PE (plastic) material.
Wherein the inflow pipe portion is made of a plastic material or a glass material.
Characterized in that the ring for preventing ball movement is made of rubber material, silicone material or PE (plastic) material.
Wherein said syringe is for separating glycated hemoglobin.
When the syringe is aspirated with the syringe and then the buffer solution is mixed with the syringe, the Brona acid contained in the latex ball binds specifically to the glucose of the glycated hemoglobin (HbA1c) contained in the blood, Wherein the hemoglobin is separated from common non-glycosylated hemoglobin (Hb).
And when the blood is sucked by the syringe, the syringe is sucked in a state that the opening of the cap is opened.
When the buffer solution is put into the syringe and mixed, the syringe containing the blood is placed in a buffer solution tube containing the buffer solution, and the cap part is closed with the through hole of the cap part being closed, whereby blood, A latex ball, and a buffer solution.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020120135927A KR101553041B1 (en) | 2012-11-28 | 2012-11-28 | Spuit |
PCT/KR2013/009491 WO2014084509A1 (en) | 2012-11-28 | 2013-10-24 | Pipette |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020120135927A KR101553041B1 (en) | 2012-11-28 | 2012-11-28 | Spuit |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20140068437A true KR20140068437A (en) | 2014-06-09 |
KR101553041B1 KR101553041B1 (en) | 2015-09-15 |
Family
ID=50828097
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020120135927A KR101553041B1 (en) | 2012-11-28 | 2012-11-28 | Spuit |
Country Status (2)
Country | Link |
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KR (1) | KR101553041B1 (en) |
WO (1) | WO2014084509A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3290114A1 (en) * | 2016-09-02 | 2018-03-07 | Bio-Rad Innovations | Pipette tip container |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105833927A (en) * | 2016-05-31 | 2016-08-10 | 四川金域医学检验中心有限公司 | Device capable of avoiding damage of pipette nozzle |
JP6104440B1 (en) * | 2016-08-17 | 2017-03-29 | 株式会社エム・ビー・エス | Blood collection device including blood collection device and blood container |
CN112403546B (en) * | 2020-10-29 | 2022-07-01 | 珠海市医友生物科技有限公司 | Chemical reagent quantitative determination equipment |
KR102445893B1 (en) | 2022-04-20 | 2022-09-21 | (주)탑바이오메디칼 | Dropping pipette |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07284674A (en) * | 1994-04-20 | 1995-10-31 | Fuji Photo Film Co Ltd | Pipette tip |
JP2004321905A (en) * | 2003-04-23 | 2004-11-18 | Enomoto Co Ltd | Disposable pipette |
JP4974067B2 (en) * | 2004-12-28 | 2012-07-11 | 株式会社吉野工業所 | Spoid discharge container |
JP2008020255A (en) * | 2006-07-11 | 2008-01-31 | Ai Bio Chips:Kk | Dropping pipet and liquid sampling method using it |
KR20110125926A (en) * | 2010-05-14 | 2011-11-22 | (주)국일글라스테크 | A spuit for preventing backdrafting |
-
2012
- 2012-11-28 KR KR1020120135927A patent/KR101553041B1/en active IP Right Grant
-
2013
- 2013-10-24 WO PCT/KR2013/009491 patent/WO2014084509A1/en active Application Filing
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3290114A1 (en) * | 2016-09-02 | 2018-03-07 | Bio-Rad Innovations | Pipette tip container |
WO2018041965A1 (en) * | 2016-09-02 | 2018-03-08 | Bio-Rad Innovations | Pipette tip container |
US11130122B2 (en) | 2016-09-02 | 2021-09-28 | Bio-Rad Europe Gmbh | Pipette tip container |
Also Published As
Publication number | Publication date |
---|---|
WO2014084509A1 (en) | 2014-06-05 |
KR101553041B1 (en) | 2015-09-15 |
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