JPS6319556A - Analyzing vessel - Google Patents
Analyzing vesselInfo
- Publication number
- JPS6319556A JPS6319556A JP16326886A JP16326886A JPS6319556A JP S6319556 A JPS6319556 A JP S6319556A JP 16326886 A JP16326886 A JP 16326886A JP 16326886 A JP16326886 A JP 16326886A JP S6319556 A JPS6319556 A JP S6319556A
- Authority
- JP
- Japan
- Prior art keywords
- blood
- plasma
- serum
- hollow part
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000002966 serum Anatomy 0.000 claims abstract description 48
- 210000002381 plasma Anatomy 0.000 claims abstract description 43
- 210000004369 blood Anatomy 0.000 claims abstract description 42
- 239000008280 blood Substances 0.000 claims abstract description 42
- 210000000601 blood cell Anatomy 0.000 claims abstract description 20
- 238000004458 analytical method Methods 0.000 claims abstract description 10
- 210000000624 ear auricle Anatomy 0.000 abstract description 4
- 238000012360 testing method Methods 0.000 description 14
- 238000005119 centrifugation Methods 0.000 description 8
- 238000002347 injection Methods 0.000 description 7
- 239000007924 injection Substances 0.000 description 7
- 238000007789 sealing Methods 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 239000011324 bead Substances 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 238000010908 decantation Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical class OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 230000002489 hematologic effect Effects 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012009 microbiological test Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000011022 operating instruction Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 230000009974 thixotropic effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Centrifugal Separators (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
この発明は血液試料を遠心分離により血球成分と血漿又
は血清成分に分離した後、血漿又は血清成分のみを取出
して臨床学的検査に用いることの可能な分析容器に関す
るものである。[Detailed Description of the Invention] [Field of Industrial Application] This invention is a method for separating a blood sample into blood cell components and plasma or serum components by centrifugation, and then extracting only the plasma or serum components for use in clinical tests. The present invention relates to possible analysis containers.
臨床検査において、血液を検体とした検査は診断上重要
な情報を提供するものであり、それらの検査は血液学的
検査、微生物学的検査、免疫血清検査及び臨床化学検査
で代表されるように多種にわたるものである。これらの
検査の中で、検体としては全血、血漿又は血清成分を用
いるが、その検査の種類により使用検体を選択する必要
がある６例えば、血液学的検査で赤血球係数、白血球係
数、ヘマトクリア）値等を測定する場合には全血をその
まま用いるが、検体として血漿又は血清成分を用いる場
合には採血管に血液を採取した後、ミれを遠心分離器に
かけて血球成分と血漿又は血清成分とに分離し。In clinical testing, tests using blood as specimens provide important diagnostic information, and these tests include hematological tests, microbiological tests, immune serum tests, and clinical chemistry tests. There are many different types. Among these tests, whole blood, plasma, or serum components are used as the specimen, but it is necessary to select the specimen to be used depending on the type of test6. When measuring values, etc., whole blood is used as it is, but when plasma or serum components are used as a specimen, the blood is collected into a blood collection tube and then centrifuged to separate blood cell components and plasma or serum components. Separate into.
その上清である血５さ又は血清成分をピペット又はデカ
ンテーションによって他の容器に分取することとなる。The supernatant blood or serum component is then fractionated into another container by pipette or decantation.
しかしながら、上記血漿又は血清成分を分取する従来法
ではその操作が煩雑であり１時間がかかる上に、検査試
料の採取ミス等が起こるという問題があり、臨床検査に
要求される正確。However, in the conventional method for separating plasma or serum components, the operation is complicated and takes an hour, and there are problems such as mistakes in collection of test samples, etc., and the precision required for clinical tests is difficult.
迅速、簡便といった条件を満足するものではない、即ち
、遠心分離してその上清をピペットやデカンテーション
によって分取する場合において、血漿又は血清成分中に
血球成分等が混入する虞れがあるし、その混入がないよ
うにするには操作者に十分な熟練と慎重さが要求されて
いたからである。It does not satisfy the requirements of being quick and simple; in other words, when centrifuging and collecting the supernatant using a pipette or decantation, there is a risk that blood cell components etc. may be mixed into plasma or serum components. This is because sufficient skill and caution were required of the operator to prevent such contamination.
また、従来、血球成分と血漿又は血清成分との分離を明
確にし２分取操作を容易にするために、血球成分と血漿
又は血清成分の中間比重をもったスチレン等のプラスチ
ックビーズやシリコン／シリカ等からなるゲル状物（チ
キソトロピー物質）を相分離材として用いることも試み
られているが２分離が不十分であったり、血清成分を得
る場合には凝固に時間を要するなどの欠点を有していた
し、遠心分離後の上清の分取操作の正確、迅速、簡便に
ついては改善されていない。In addition, conventionally, in order to clearly separate blood cell components and plasma or serum components and to facilitate the two-part collection operation, plastic beads such as styrene or silicone/silica beads with intermediate specific gravity between blood cell components and plasma or serum components have been used. Attempts have been made to use gel-like substances (thixotropic substances) consisting of However, the accuracy, speed, and ease of separating the supernatant after centrifugation have not been improved.
また、近年１分析技術の進歩は著しく、掻く微量の血液
で各種の血液検査が可能になった。Furthermore, in recent years, analytical technology has made remarkable progress, and it has become possible to perform various blood tests using only a small amount of blood that is scraped.
例えば、臨床化学検査におけるドライケミストリーが挙
げられる。このドライケミストリーは試薬を含浸したド
ライシートを用い、これに検体試料を供給して反応させ
、その反応による色の濃度変化を反射法により測光する
ことによって検体試料を測定するもので、湿式法のよう
に試薬類の調整１反応容器の準備、使用後のヰ★体の処
理、検体試料や試薬等の秤量、希釈、操作法に従った混
合等の操作が不要となる。このドライシートとしては水
不透過性の透明支持体上に検体と反応して選択的に発色
する試薬層を設け、その上に検体試料をその容量に比例
した面積で拡散される展開層を備えた分析素子を用いる
ことが多（、検体試料は展開層上に１０μ！程度供給す
るのみで検査できる。An example is dry chemistry in clinical chemistry testing. This dry chemistry uses a dry sheet impregnated with a reagent, supplies the specimen sample to it, causes it to react, and measures the specimen sample by photometrically measuring the change in color density due to the reaction. This eliminates the need for preparation of reagents, preparation of reaction vessels, treatment of the body after use, weighing of specimens and reagents, dilution, mixing according to operating instructions, etc. This dry sheet has a reagent layer that selectively develops color by reacting with the sample on a water-impermeable transparent support, and a developing layer on top of which the sample is diffused in an area proportional to its volume. A test sample can be tested by simply supplying about 10 microns of the sample onto the developing layer.
前記のドライケミストリーによれば、検査の 。According to the dry chemistry mentioned above, the test.
ために多量の血液を採取する必要もなく、特に新生児な
どのように、採血針による採取が困難な場合等において
、被検者の身体的、精神的負担を軽減する。少量の血液
の採取の方法としては、ガラス毛細管が使用され、被検
者の耳朶や指先等を穿孔し、この部分にガラス毛細管を
当ててその毛細管現象を利用して行われる。このように
して毛細管内に採取した血液試料は遠心分離により血球
成分と血漿又は血清成分に分離し９毛細管の上方に分離
された血竪又は血清成分を取り出して検体試料とするが
、管が細いためその操作はかなり面倒であった。Therefore, there is no need to collect a large amount of blood, which reduces the physical and mental burden on the subject, especially in cases where it is difficult to collect blood with a blood collection needle, such as in newborns. To collect a small amount of blood, a glass capillary tube is used, a hole is made in the subject's earlobe or fingertip, and the glass capillary tube is applied to this area to utilize the capillary phenomenon. The blood sample collected in the capillary in this way is separated into blood cell components and plasma or serum components by centrifugation, and the separated blood column or serum component is taken out above the capillary and used as a specimen sample, but the tube is thin. Therefore, the operation was quite troublesome.
この発明は上記の点に鑑み、採取した血液試料を遠心分
離により血球成分と血漿又は血清成分とに分離した後、
その血漿又は血清成分を別の容器等に取り出すことなく
、直に分析素子に適用できるようにした分析容器を提供
することを目的としている。In view of the above points, this invention separates a collected blood sample into blood cell components and plasma or serum components by centrifugation, and then
The object of the present invention is to provide an analysis container that allows plasma or serum components to be directly applied to an analysis element without having to take them out into a separate container or the like.
上記目的を達成するため、この発明は血液試料の保持可
能な中空部を有し、該中空部の少なくとも一個所から外
部に通じる分岐孔を設け。To achieve the above object, the present invention has a hollow part capable of holding a blood sample, and a branch hole communicating with the outside from at least one part of the hollow part.
この分岐孔を通して血漿又は血清成分が血球成分から独
立に取り出せるように構成したものである。具体的には
前記中空部を毛細管とし、該中空部に採血後、その封緘
側を外方にして遠心分離器にかけたときに１．血球成分
と血漿又は血清成分とが分離する分境面より血漿又は血
清成分側に前記分岐孔を設けるとともに、該分岐孔を中
空部の軸方向に対して直角乃至血漿又は血清成分側に傾
けるように構成したものである。The structure is such that plasma or serum components can be taken out independently from blood cell components through this branch hole. Specifically, when the hollow part is made into a capillary tube, blood is collected into the hollow part, and then centrifuged with the sealed side facing outward, 1. The branch hole is provided on the plasma or serum component side of the dividing surface where blood cell components and plasma or serum components are separated, and the branch hole is tilted at right angles to the axial direction of the hollow portion or toward the plasma or serum component side. It is composed of
次に、この発明を添付図面を参照しながらさらに詳説す
る。Next, the present invention will be explained in more detail with reference to the accompanying drawings.
第１図乃至第４閏はこの発明の第一実施例を示すもので
１図において、■は透明性の材料により成形した容器本
体５２は容器本体１を貫通するように設けた血液試料の
保持可能な中空部である。中空部２は好ましくは５ ｗ
以下、さらに好ましくは３璽負以下の内径の毛細管とし
、その両端２３．２ｂは容器本体１の両端面より突出し
た状態で開口している。なお１本実施例では容器本体１
と中空部２は一体成形されているが、容器本体１に毛細
管を貫通させて中空部２として構成するようにしてもよ
い。Figures 1 to 4 show the first embodiment of the present invention. It is a possible hollow part. The hollow part 2 is preferably 5w
Hereinafter, it is more preferable to use a capillary tube having an inner diameter of 3 mm or less, and both ends 23.2b thereof are open and protrude from both end surfaces of the container body 1. Note that in this embodiment, the container body 1
Although the hollow part 2 and the hollow part 2 are integrally molded, the hollow part 2 may be formed by passing a capillary tube through the container body 1.
３は前記中空部２の一端２ａを例えば耳朶。3 designates one end 2a of the hollow portion 2 as, for example, an earlobe.
指先又は踵等の穿孔部分に当てて血液試料を毛細管現象
を利用して採取する場合の採取量を示す指示線で、該指
示線３は容器本体１の外面に表示されている。勿論、中
空部２が容器本体１と別体の毛細管で構成されていると
きは、その毛細管自身の外周面に表示してもよい。This indicator line 3 is displayed on the outer surface of the container body 1 and indicates the amount to be collected when a blood sample is collected by applying capillary action to a perforated part such as a fingertip or a heel. Of course, when the hollow part 2 is constituted by a capillary tube separate from the container body 1, it may be displayed on the outer peripheral surface of the capillary tube itself.
なお、採取した血液試料から血漿又は血清成分のみを検
査試料として用いる場合には採取した血液試料に抗凝固
剤（例えばＥＤＴＡ塩、ヘパリン）を加えるか、中空部
２の内壁に薄く塗っておくことが好ましい。In addition, when using only plasma or serum components from the collected blood sample as a test sample, add an anticoagulant (for example, EDTA salt, heparin) to the collected blood sample, or apply it thinly to the inner wall of the hollow part 2. is preferred.
４は前記中空部２から容器本体１の外部に通じるように
設けた分岐孔で、該分岐孔４は遠心分離により中空部２
内で第２図示の如く血球成分５と血漿又は血清成分６と
に分離した後、血漿又は血清成分６のみを外部に取り出
すためのものである。従って、中空部２の一端２ａから
前記指示線３まで血液試料を採取した後、その一端２ａ
を熔融するか、適当な封緘部材７で封緘し、該封緘側を
外方にして第３図示の如く遠心分離器８に設置し、該遠
心分離器８の作動で分離した血球成分５と血漿又は血清
成分６との分境面９より血漿又は血清成分側に設けられ
ている。この分境面９は血液試料により前後に移動する
ため、前記分岐孔４はその移動量の最大範囲を予め想定
して設けることが好ましいものである。また９分岐孔４
は中空部２の軸方向に対して直角乃至血漿又は血清成分
６側に傾いている。これは前述の如く、採血時に血液試
料が分岐孔４にまで浸入した場合でも遠心分離時に中空
部２内に戻されるようにするためである。4 is a branch hole provided so as to communicate from the hollow part 2 to the outside of the container body 1, and the branch hole 4 is connected to the hollow part 2 by centrifugation.
After the blood cell component 5 and plasma or serum component 6 are separated as shown in the second figure, only the plasma or serum component 6 is taken out. Therefore, after collecting a blood sample from one end 2a of the hollow part 2 to the indicated line 3, the one end 2a
The blood cell component 5 and plasma separated by the operation of the centrifuge 8 are melted or sealed with a suitable sealing member 7, and placed in a centrifuge 8 as shown in the third figure with the sealed side facing outward. Alternatively, it is provided closer to the plasma or serum component side than the boundary surface 9 with the serum component 6. Since this dividing surface 9 moves back and forth depending on the blood sample, it is preferable to provide the branching hole 4 with the maximum range of its movement assumed in advance. Also 9 branch holes 4
is perpendicular to the axial direction of the hollow portion 2 or inclined toward the plasma or serum component 6 side. This is to ensure that even if the blood sample penetrates into the branch hole 4 during blood collection, it will be returned to the hollow portion 2 during centrifugation, as described above.
１０は前記分岐孔４の外端に円錐状に設けた口部で、該
口部１０は分岐孔４を通して血漿又は血清成分６を取り
出すときに玉状に液ギレよく滴下できるようにするため
のものである。この口部１０は必要に応じてその先端に
キャップ又はシール（図示せず）を施すようにしてもよ
い、また１口部１０は図示の例では容器本体１の外面に
突出状に設けているが、容器本体１側を凹状にし１口部
１０が容器本体ｌの外面から突出しないようにしてもよ
い。Reference numeral 10 denotes a conical mouth provided at the outer end of the branch hole 4, and the mouth 10 is designed to allow the liquid to drip easily in a bead shape when plasma or serum components 6 are taken out through the branch hole 4. It is something. This mouth part 10 may be provided with a cap or a seal (not shown) at its tip if necessary, and in the illustrated example, one mouth part 10 is provided in a protruding manner on the outer surface of the container body 1. However, the side of the container body 1 may be made concave so that the one mouth portion 10 does not protrude from the outer surface of the container body 1.
前記遠心分離器８はロータ８ａ内に容器本体ｌが固定で
きるｉ８ｂを有するヘマトクリット遠心分離器を用いる
のが望ましい、このロータ８ａの回転数は３，０００〜
１５．００Ｏｒｐｍが得られるものがよい。As the centrifugal separator 8, it is preferable to use a hematocrit centrifugal separator having an i8b in which the container body l can be fixed in the rotor 8a, and the rotation speed of the rotor 8a is 3,000 to
One that can provide 15.00 Orpm is preferable.
上記実施例の分析容器を用いて採血する場合は１例えば
耳朶、指先又は踵等を穿孔して血液を出し、その第−滴
を拭い去り２次の血清に中空部２の一端２ａを当て、そ
の毛細管現象を利用して採取する。そして、血液試料が
採取量を示す指示線３に達した時点で穿孔部分より離反
する。When collecting blood using the analysis container of the above embodiment, 1. For example, puncture the earlobe, fingertip, or heel to draw blood, wipe off the first drop, and 2. apply the first end 2a of the hollow part 2 to the second serum. It is collected using the capillary phenomenon. Then, when the blood sample reaches the indicator line 3 indicating the amount to be collected, it separates from the perforation part.
しかる後、中空部２の一端２ａを溶融或いは封緘部材７
を用いて封緘し、遠心分離器８にがければ比重差によっ
て重い血球成分５と軽い血漿又は血清成分６とに分離す
る。遠心分離が終了したならば、必要に応じてヘマトリ
ット値の測定（この測定を必須とする場合には中空部２
の長さ方向に反って容器本体１の外面に必要な目盛を付
しておく、）を行った後、第４図示の如く分岐孔４を下
向きにして分析素子１１に対峙させる。この場合におい
て１分岐孔４と分析素子１１との位置決めは容器本体１
が透明性のものであれば目視によっても可能であるが、
容器本体１の外面に位置決めマークを設けるが。After that, one end 2a of the hollow part 2 is melted or sealed with a sealing member 7.
When the sample is sealed using a centrifuge 8, it is separated into a heavy blood cell component 5 and a light plasma or serum component 6 due to the difference in specific gravity. After centrifugation is complete, measure the hematolite value as necessary (if this measurement is essential,
After applying necessary scale marks on the outer surface of the container body 1 by bending it in the length direction, the branch hole 4 is faced downward to face the analytical element 11 as shown in the fourth figure. In this case, the positioning of the first branch hole 4 and the analytical element 11 is determined by the container body 1.
If it is transparent, it is possible to visually inspect it, but
Positioning marks are provided on the outer surface of the container body 1.
特別な位置決め用の器具を用いるようにしてもよい。Special positioning tools may also be used.
このようにして分岐孔４を分析素子１１に対峙させた後
、中空部２の他端２ｂにピペッタ−１２を接続（この中
空部２の他端２ｂは通當のピペツタ−に接続可能な形態
を有していることが好ましい、）シ、その押杆１３を第
４図の矢印の如く押せば、血漿又は血清成分６は分岐孔
４を通じて外部に押し出され２分析素子１１に適用され
ることとなる。After the branch hole 4 is made to face the analysis element 11 in this way, the pipettor 12 is connected to the other end 2b of the hollow part 2 (the other end 2b of the hollow part 2 is configured so that it can be connected to a regular pipettor). ) If the push rod 13 is pushed in the direction of the arrow in FIG. becomes.
第５図はこの発明の第二実施例を示す、この場合は血液
試料の保持を可能にした中空部２の３個所から外部に通
じる分岐孔４．４’、４″が設けられている。この分岐
孔４〜４＃のうち中空部２の中間部の分岐孔４は前述し
た血漿又は血清成分６の取り出し用の孔であり、中空部
２の一端２ａ側の分岐孔４′は血液注入用、他端２ｂ側
の分岐孔４“はピペッタ−に接続する空気注入用の孔で
ある。これら血液注入用及び空気注入用の分岐孔４’、
４”は通常はゴム栓や簡易シール部材（図示せず）で封
緘されている。しかして、この第二実施例の中空部２に
血液試料を注入するには、まず、中空部２の一端２ａを
封緘部材７で封緘する。そして、血液注入用分岐孔４′
を開口し、そこから注射器により直接指示線３まで注入
する１次いで、血液注入用の分岐孔４′を封栓し、前述
したと同様に遠心分離器にかけ、血球成分５と血漿又は
血清成分６とに分離し１分岐孔４を下向きにして分析素
子に対峙させるとともに、上向きになった空気注入用の
分岐孔４″にピペッタ−を接続してその押杆を操作すれ
ば、血漿又は血清成分を分岐孔４を通じて押し出せるこ
ととなる。FIG. 5 shows a second embodiment of the present invention, in which branch holes 4.4', 4'' are provided which communicate with the outside from three locations in the hollow part 2, which make it possible to hold a blood sample. Among these branch holes 4 to 4#, the branch hole 4 in the middle part of the hollow part 2 is a hole for taking out the plasma or serum component 6 mentioned above, and the branch hole 4' on the one end 2a side of the hollow part 2 is a hole for blood injection. The branch hole 4'' on the other end 2b side is an air injection hole connected to a pipetter. These branch holes 4' for blood injection and air injection,
4'' is normally sealed with a rubber stopper or a simple sealing member (not shown).However, in order to inject a blood sample into the hollow part 2 of this second embodiment, first, one end of the hollow part 2 is sealed. 2a is sealed with the sealing member 7. Then, the branch hole 4' for blood injection is sealed.
and inject directly from there to the indicated line 3 with a syringe.1 Next, the branch hole 4' for blood injection is sealed and centrifuged in the same manner as described above to separate the blood cell component 5 and plasma or serum component 6. Plasma or serum components can be separated into two parts, with the first branch hole 4 facing downward and facing the analysis element, and by connecting a pipetter to the upward branch hole 4'' for air injection and operating its push rod. can be pushed out through the branch hole 4.
第６図はこの発明の第三実施例を示す、この場合は血液
試料の保持を可能にした中空部２の他端２ｂ側を分岐孔
４の設置方向と逆向きに圧油したものである。これは血
漿又は血清成分を取り出すときに分岐孔４を下向きにす
ると、中空部２の他端２ｂ側が上向きになり、ピペッタ
−の接続が垂直方向から楽に行えるようにしている。な
お、これ以外の作用については第一実施例の場合と同様
である。FIG. 6 shows a third embodiment of the present invention. In this case, the other end 2b side of the hollow portion 2, which is capable of holding a blood sample, is oiled under pressure in the opposite direction to the installation direction of the branch hole 4. . This is because when the branch hole 4 is turned downward when plasma or serum components are taken out, the other end 2b of the hollow part 2 is turned upward, so that the pipettor can be easily connected from the vertical direction. Note that the other functions are the same as in the first embodiment.
以上の如く、この発明は血液試料の保持可能な中空部を
有し、該中空部の少なくとも一個所から外部に通じる分
岐孔を設けたことを特徴としているから、採取した血液
試料を遠心分離により血球成分と組木又は血清成分とに
分離した後、所定の部位より圧力を加えるだけで直に分
析素子に適用できる。従って、その操作が極めて簡単に
なるとともに、血漿又は血清成分のみの抽出が正確かつ
迅速にできるという優れた効果を奏するものである。As described above, the present invention is characterized by having a hollow part capable of holding a blood sample and having a branch hole communicating with the outside from at least one part of the hollow part, so that the collected blood sample can be centrifuged. After separating into blood cell components and tissue or serum components, it can be applied directly to the analytical element simply by applying pressure from a predetermined location. Therefore, the operation is extremely simple, and the excellent effect that only plasma or serum components can be extracted accurately and quickly is achieved.
第１図乃至第４図はこの発明の第一実施例を示すもので
、第１図は外観斜視図、第２図は血液試料の遠心分離後
の状態を示す断面図、第３図は遠心分離器のロータ部分
の斜視図、第４図は血漿又は血清成分の取り出し時の作
用を示す断面図、第５図は第二実施例の断面図、第６図
は第三実施例の断面図である。
■・−容器本体
２・−中空部
３・−指示線
４、 ４ ’、 ４ ’−−−−分岐孔５−・・血球
成分
６−・血漿又は血清成分
７−・封緘部材
特 許 出願人 小西六写真工業株式会社第［図
ｑ
第２図
第３図
第４図
第５図
第６図1 to 4 show a first embodiment of the present invention, in which FIG. 1 is a perspective view of the external appearance, FIG. 2 is a sectional view showing the state after centrifugation of a blood sample, and FIG. 3 is a centrifugal view of the blood sample. A perspective view of the rotor portion of the separator, FIG. 4 is a cross-sectional view showing the action when taking out plasma or serum components, FIG. 5 is a cross-sectional view of the second embodiment, and FIG. 6 is a cross-sectional view of the third embodiment. It is. - Container body 2 - Hollow part 3 - Indication lines 4, 4', 4' - Branch hole 5 - Blood cell component 6 - Plasma or serum component 7 Sealing member patent Applicant Konishiroku Photo Industry Co., Ltd. [Figure q Figure 2 Figure 3 Figure 4 Figure 5 Figure 6
Claims (4)
少なくとも一個所から外部に通じる分岐孔を設けたこと
を特徴とする分析容器。(1) An analysis container characterized by having a hollow part capable of holding a blood sample and having a branch hole communicating with the outside from at least one part of the hollow part.
項記載の分析容器。(2) Claim 1, wherein the hollow portion is a capillary tube.
Analytical container as described in section.
分離器にかけたときに、血球成分と血漿又は血清成分と
が分離する分境面より血漿又は血清成分側に設けられて
いる特許請求の範囲第１項又は第２項記載の分析容器。(3) The branch hole is provided on the plasma or serum component side of the dividing surface where blood cell components and plasma or serum components are separated when the hollow part is centrifuged with the sealed side facing outward. An analysis container according to claim 1 or 2.
血漿又は血清成分側に傾いている特許請求の範囲第１項
〜第３項のうちの１項記載の分析容器。(4) The analysis container according to any one of claims 1 to 3, wherein the branch hole is perpendicular to the axial direction of the hollow portion or inclined toward the plasma or serum component side.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16326886A JPS6319556A (en) | 1986-07-11 | 1986-07-11 | Analyzing vessel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16326886A JPS6319556A (en) | 1986-07-11 | 1986-07-11 | Analyzing vessel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6319556A true JPS6319556A (en) | 1988-01-27 |
| JPH0545186B2 JPH0545186B2 (en) | 1993-07-08 |
Family
ID=15770576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP16326886A Granted JPS6319556A (en) | 1986-07-11 | 1986-07-11 | Analyzing vessel |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6319556A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2006011393A1 (en) * | 2004-07-29 | 2008-05-01 | 松下電器産業株式会社 | Analysis device, analysis disk, and analysis system including them |
| JP2008145420A (en) * | 2006-12-11 | 2008-06-26 | Samsung Electronics Co Ltd | Component separation device and component separation method |
| JP2017514145A (en) * | 2014-03-21 | 2017-06-01 | デーベーエス・システム・ソシエテ・アノニム | Devices and methods for separating fluid mixtures such as blood |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53132074U (en) * | 1977-03-26 | 1978-10-19 | ||
| JPS53132073U (en) * | 1977-03-26 | 1978-10-19 |
-
1986
- 1986-07-11 JP JP16326886A patent/JPS6319556A/en active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53132074U (en) * | 1977-03-26 | 1978-10-19 | ||
| JPS53132073U (en) * | 1977-03-26 | 1978-10-19 |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2006011393A1 (en) * | 2004-07-29 | 2008-05-01 | 松下電器産業株式会社 | Analysis device, analysis disk, and analysis system including them |
| JP4665902B2 (en) * | 2004-07-29 | 2011-04-06 | パナソニック株式会社 | Analysis device, analysis disk, and analysis system including them |
| JP2008145420A (en) * | 2006-12-11 | 2008-06-26 | Samsung Electronics Co Ltd | Component separation device and component separation method |
| JP2017514145A (en) * | 2014-03-21 | 2017-06-01 | デーベーエス・システム・ソシエテ・アノニム | Devices and methods for separating fluid mixtures such as blood |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0545186B2 (en) | 1993-07-08 |
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