CN219540345U

CN219540345U - Sample collection container, centrifugal component and sample analyzer

Info

Publication number: CN219540345U
Application number: CN202320239723.1U
Authority: CN
Inventors: 方忠启; 廖闽
Original assignee: Shenzhen Dymind Biotechnology Co Ltd
Current assignee: Shenzhen Dymind Biotechnology Co Ltd
Priority date: 2023-01-30
Filing date: 2023-01-30
Publication date: 2023-08-18
Anticipated expiration: 2033-01-30

Abstract

The utility model discloses a sample collection container, a centrifugal component and a sample analyzer, wherein the sample collection container comprises a sample collection tube; the sample collection tube comprises an outer tube body and a sample storage tube suspended in the outer tube body; the top opening of the outer tube body forms a sampling port, and a sample scraping sheet extending outwards is arranged on the sampling port; the sample storage tube comprises a cone tube section, a middle tube section and an inclined tube section which are connected in sequence in the axial direction; the top of the inclined surface pipe section is connected with the included angle of the inner surface of the upper end of the outer pipe body and is communicated with the sampling port of the outer pipe body; the interior space of the cone pipe section forms a sample storage cavity. Compared with the traditional blood sampling operation, the sample collection container provided by the utility model is more rapid to use, and disposable consumables can be reduced.

Description

Sample collection container, centrifugal component and sample analyzer

Technical Field

The utility model relates to the technical field of medical instruments, in particular to a sample collection container, a centrifugal component and a sample analyzer.

Background

Venous blood and peripheral blood are clinical blood test specimens. Along with the continuous development and increasing perfection of modernization, micro-quantization and convenience of the inspection medical technology, the application of peripheral blood is also becoming wider and wider. Because children have poor autonomous cooperation compliance and fine blood vessels, in the venous blood sample collection process, compared with adults, the success rate of blood collection is low, and the complication occurrence rate is higher, the peripheral blood collection has an indispensable position in pediatric clinical work. Compared with venous blood, the peripheral blood has more influencing factors, such as irregular operation in the acquisition process, which easily causes variation or inaccuracy of detection results, so that the convenient and quick trace blood collection tube can bring great convenience to patients and medical staff, and can improve the quality of peripheral blood specimen inspection.

Common peripheral blood sampling modes are: the skin is pierced with a tip hemostix (usually a sharp needle or blade), then a disposable hollow glass or plastic pipette with a quantitative indicator is used, the pipette is allowed to flow into the tube by siphoning blood, and the blood sample in the pipette is added dropwise to the beaker or microtube to be tested. However, the above blood sampling method has the following drawbacks: complicated operation, inconvenience and high disposable consumable consumption.

Disclosure of Invention

The utility model aims to solve the technical problem of providing a sample collection container which is rapid in sampling operation, a centrifugal component for centrifugal treatment of the sample collection container and a sample analyzer for detection of the sample collection container.

The technical scheme adopted for solving the technical problems is as follows: providing a sample collection container comprising a sample collection tube; the sample collection tube comprises a transparent or semitransparent outer tube body and a sample storage tube suspended in the outer tube body;

the top opening of the outer tube body forms a sampling port, and a sample scraping sheet extending outwards is arranged on the sampling port;

the sample storage tube comprises a cone tube section, a middle tube section and an inclined tube section which are connected in sequence in the axial direction; the top of the inclined surface pipe section is connected with the included angle of the inner surface of the upper end of the outer pipe body and is communicated with the sampling port of the outer pipe body; the interior space of the cone pipe section forms a sample storage cavity.

Preferably, the bottom of the outer tube body is open, and a space between the inner surface of the outer tube body and the outer surface of the sample storage tube communicates with the external environment through the open bottom.

Preferably, the inner diameter of the inclined tube section gradually decreases from the end to which the outer tube body is connected to the end to which the intermediate tube section is connected.

Preferably, the outer surface of the taper pipe section is provided with at least one scale mark for indicating the volume; the scale marks are formed by annular bulges arranged on the outer surface of the taper pipe section.

Preferably, the outer surface of the taper pipe section is provided with three scale marks for indicating different volumes;

the three scale marks are positioned at the upper end of the taper pipe section, connected with the middle pipe section, and sequentially distributed at intervals along the axial direction of the taper pipe section.

Preferably, the sample collection container further comprises a cap which seals against the top of the sample collection tube to close the sample port.

Preferably, the cap is provided with a sampling hole communicated with the sample storage tube.

Preferably, a sealing layer which extends radially to isolate the sampling hole and can be pierced by the sampling needle is arranged in the sampling hole.

Preferably, an annular wall surrounding the sampling hole is arranged in the cap, and an annular space is reserved between the annular wall and the inner peripheral wall surface of the cap;

the top of the outer tube body is inserted into the annular space of the cap, and the outer wall surface of the annular wall is tightly matched with the top inner surface of the outer tube body;

the outer surface of the upper end of the outer tube body is provided with a convex annular enclosing wall; the end face of the cap facing the sample collection tube abuts against the annular surrounding wall.

The utility model also provides a centrifuge assembly for loading a sample collection container as described in any one of the preceding claims; the sample collection container contains a sample to be tested;

the centrifugal component is used for carrying out centrifugal treatment on the sample collection container so as to obtain a layered sample to be tested after centrifugation.

The present utility model also provides a sample analyzer comprising:

a sample loading assembly comprising at least one detent for placement of the sample collection container of any of the above;

the sample sucking assembly is used for controlling the sample sucking needle to downwards extend to the sample collecting container so as to suck the sample to be detected in the sample collecting container;

the detection component is used for detecting the sample to be detected to obtain a detection result of the sample to be detected;

the sample loading assembly, the sample absorbing assembly and the detection assembly are arranged at intervals, and the sample loading assembly is positioned on the movement path of the sample absorbing needle of the sample absorbing assembly.

Preferably, a fixed upright post is arranged in the positioning groove, the fixed upright post is inserted into the outer tube body of the sample collection container, and the outer surface of the fixed upright post is attached to the inner surface of the outer tube body so as to improve the capacitance change value of the sample liquid level in the sample storage tube.

Preferably, the sample analyzer further comprises: a scheduling component and a centrifugation component;

the dispatching assembly is used for dispatching the sample collection container to the centrifugal assembly;

Preferably, the sample analyzer is an immunoassay analyzer, and the sample analyzer further comprises:

the incubation assembly is used for carrying out incubation treatment on liquid loaded by the reaction cup, wherein the liquid comprises the sample to be detected and the reagent sucked by the sample sucking assembly;

the magnetic separation component is used for performing magnetic separation treatment on the sample to be detected after incubation treatment;

the detection component is used for detecting the sample to be detected after the magnetic separation treatment.

The utility model has the beneficial effects that: the sample collection container is through scraping the segmentation setting of sample wafer and stock pipe on the outer body, can realize in order to scrape blood sampling's mode, and the blood sample flows into the taper pipe section through the slope of the inclined plane pipeline section of sampling pipe in automatically, compares traditional blood sampling operation and uses swiftly to can reduce disposable consumptive material and use.

The sample collection container is suitable for single-sample handheld test and full-automatic instrument batch sample rack mode test.

Drawings

The utility model will be further described with reference to the accompanying drawings and examples, in which:

FIG. 1 is a schematic exploded view of a sample collection container according to an embodiment of the present utility model;

FIG. 2 is a schematic axial cross-sectional view of a sample collection container according to an embodiment of the present utility model;

FIG. 3 is a schematic view of the sample collection tube of FIG. 2;

FIG. 4 is a schematic view of the structure of a sample collection container on a sample rack according to an embodiment of the present utility model;

fig. 5 is a block diagram of a sample analyzer according to an embodiment of the present utility model.

Detailed Description

For a clearer understanding of technical features, objects and effects of the present utility model, a detailed description of embodiments of the present utility model will be made with reference to the accompanying drawings.

As shown in fig. 1-3, a sample collection container in accordance with an embodiment of the present utility model may include a sample collection tube 10 and a cap 20 that fits over sample collection tube 10.

The sample collection tube 10 includes an outer tube 11 and a sample storage tube 12 suspended in the outer tube 11. The sampling tube 12 is used for storing a sampled sample (such as a blood sample) 30, and the outer tube 11 is located at the periphery of the sampling tube 12, so as to play a supporting role. To facilitate the observation of the condition of the sample storage tube 11, such as the sample storage amount, the outer tube body 11 is provided to be transparent or translucent.

Specifically, the outer tube 11 is a tube body having opposite end portions open. Taking the sample collection tube 10 in fig. 2 as an example, the upward end of the outer tube 11 is the top and the downward end is the bottom. The top opening of the outer tube 11 forms a sampling port 110, and the sampling port 110 is provided with a sample scraping sheet 111 extending outwards; the sampling tube 12 is connected below the sampling port 110 within the outer tube 11. In sampling, for example, a blood sample is scraped and collected by the scraping sheet 111 into the sample tube 12.

The wiper blade 111 may be in the form of a plate having an arc-shaped protrusion in a direction parallel to the axial direction of the outer tubular body 11.

The bottom of the outer tube 11 is opened so that a space between the inner surface of the outer tube 11 and the outer surface of the sampling tube 12 can communicate with the external environment through the opened bottom. For example, in the warm bath, the warm liquid can enter and fill the space between the outer tube 11 and the sample storage tube 12, so that the sample storage tube 12 can be sufficiently contacted with the warm liquid, and the warm bath effect can be improved.

In the outer tube 11, the axial direction of the sample storage tube 12 is parallel to the axial direction of the outer tube 11, and the central axis of the sample storage tube 12 is located on the central axis of the outer tube 11, i.e., both are coaxially arranged. The sampling tube 12 and the outer tube 11 can be integrally formed.

In the present utility model, the sample storage tube 12 includes a taper tube segment 121, a middle tube segment 122, and a bevel tube segment 123 that are connected in this order in the axial direction. The top of the inclined tube section 123 far away from the middle tube section 122 is connected with the inner surface of the upper end of the outer tube 11, and is communicated with the sampling port 110 of the outer tube 11. The intermediate pipe section 122 and the taper pipe section 121 are connected in sequence below the bevel pipe section 123.

The inclined surface pipe section 123 is a pipe section structure with a trapezoid longitudinal section, the inner surface and the outer surface of the inclined surface pipe section 123 are inclined surfaces which are inclined relative to the central axis of the inclined surface pipe section 123, the inclined surface pipe section 123 is connected with the outer pipe body 11 at one end with a larger diameter, and the middle pipe section 122 is connected at one end with a smaller diameter, namely: the inner diameter of the beveled pipe section 123 gradually decreases from the end where the outer pipe body 11 is connected to the end where the intermediate pipe section 122 is connected.

The inner surface of the inclined surface pipe section 123 can play a role in guiding the sample, and the sample collected by the sampling port 110 enters the middle pipe section 122 along the inner surface of the inclined surface pipe section 123 and finally falls into the cone pipe section 121.

The intermediate pipe section 122 is connected below the beveled pipe section 123, and the outer surface of the intermediate pipe section 122 is connected to the outer surface of the beveled pipe section 123 at an angle, preferably at an obtuse angle.

The intermediate pipe section 122 may be a straight pipe having a uniform inner diameter, which may have an inner diameter (or outer diameter) comparable to the smaller inner diameter (or outer diameter) end of the beveled pipe section 123. Alternatively, the intermediate pipe section 122 may be a pipe section having a smaller inner diameter, and the inclined pipe section 123 may be connected to the end having a larger inner diameter, and the taper pipe section 121 may be connected to the end having a smaller inner diameter.

The cone section 121 is connected below the intermediate section 122 and also forms the closed end of the sampling tube 12. The internal space of the cone pipe section 121 forms a sample storage cavity 120, and the sample storage cavity 120 has a certain depth and small volume, and is suitable for collecting and storing samples with small required storage quantity.

The outer surface of the cone pipe section 121 is provided with at least one scale mark 124 for indicating the volume, and the scale mark 124 can be observed through the outer pipe body 11, so that the sampling volume can be conveniently observed in the sampling process.

To meet the different sample volume requirements of the sample, the outer surface of the cone segment 121 may be provided with three graduation marks 124 for indicating the different volumes. Three graduation marks 124 are positioned at the upper end of the taper pipe section 121 connected with the middle pipe section 122 and are sequentially arranged at intervals along the axial direction of the taper pipe section 121, and different volumes are represented by the arrangement of different heights on the taper pipe section 121. In an alternative arrangement, three graduation marks 124 may correspond to sample volume heights of 80ul, 100ul, and 120ul, respectively.

Preferably, in this embodiment, as shown in fig. 2 and 3, the graduation marks 124 are formed by annular protrusions provided on the outer surface of the taper pipe section 121. The annular protrusion may further be colored to be more clearly visible through the outer tubular body 11.

The height of the annular bulge is 0.05 mm-0.1 mm.

Referring to fig. 1 and 2, cap 20 seals against the top of sample collection tube 10, closing sampling port 110, preventing dust from falling into sample tube 12 and spillage of the sample therein.

To facilitate pre-detection sampling, the cap 20 is provided with sampling holes 200, and the sampling holes 200 penetrate opposite sides of the cap 20 and are communicated with the sampling tube 12 through the sampling ports 110. In sampling, a sampling needle is inserted from the sampling hole 200 into the sampling tube 12 to suck the sample in the taper tube segment 121.

Further, a sealing layer 201 extending radially to block the sampling hole 200 is disposed in the sampling hole 200, and the sealing layer 201 can be pierced by a sampling needle. After sampling is completed, sample collection tube 10 closes its sampling port 110 by the engagement of cap 20 on top of sample collection tube 10, as well as the sample within sample tube 12. During sampling, the sampling needle pierces the sealing layer 201 and then enters the sample storage tube 12, so that the sample in the sample storage tube 12 can be sucked.

The sealing layer 201 may be integrally formed in the cap 20 and made of the same material as the cap 20. The sealing layer 201 omits the arrangement of the rubber plug on the cap 20, and further reduces the plug-in operation of the rubber plug. It will be appreciated that, to facilitate piercing of the sampling needle, the seal 201 need not be provided too thickly, but need only be sufficient to seal the sampling aperture 200 and be able to be pierced by the sampling needle with normal downward movement of the sampling force.

In addition, in the present embodiment, an annular wall 202 surrounding the sampling hole 200 is provided in the cap 20, and an annular space 203 is left between the annular wall 202 and the inner peripheral wall surface of the cap 20 for sealing the cap 20 on the sample collection tube 10; the outer surface of the upper end of the outer tube 11 is provided with a protruding annular surrounding wall 112.

When the cap 20 is matched with the sample collection tube 10, the top of the outer tube body 11 is inserted into the annular space 203 of the cap 20, the outer wall surface of the annular wall 202 is tightly matched with the inner surface of the top of the outer tube body 11, the end surface of the cap 20, which faces the sample collection tube 10, is abutted on the annular surrounding wall 112, the tight fit of the cap 20 on the top of the sample collection tube 10 is realized, and the sample leakage is prevented.

The sample collection container is suitable for single-sample handheld test, batch sample rack mode test of a full-automatic instrument, and centrifugal treatment to obtain a sample to be tested after centrifugal layering.

As shown in fig. 4, the sample collection tube 10 of the sample collection container is shown in a resting position on the sample holder 40. Wherein at least one detent 400 is provided on the sample holder 40, and the sample collection container is placed with its sample collection tube 10 in the detent 400. The depth of the detent 400 is parallel to the axial direction of the sample collection container.

In the embodiment shown in fig. 4, a plurality of side-by-side positioning slots 400 are provided on the sample holder 40, and a sample collection container can be placed in each positioning slot 400.

In other embodiments, multiple detents 400 on the sample rack 40 may form multiple rows to hold more sample collection containers.

Further, referring to fig. 2 and 4, a fixing post (not shown) may be disposed in each positioning slot 400. After the sample collection container is placed in the positioning groove 400, the fixing upright post is inserted into the outer tube 11 of the sample collection container, and the outer surface of the fixing upright post is attached to the inner surface of the outer tube 11, so that the capacitance change value of the sample liquid level in the sample collection tube 12 is improved, and the accuracy of liquid level detection is further improved. The fixed upright is preferably a metal post.

The sample collection container can also be matched with anticoagulant or non-anticoagulant and the like to meet various detection requirements.

Furthermore, the sample collection container can be used for a sample analyzer to realize automatic detection of samples. Referring to fig. 5, in one embodiment of a sample analyzer, the sample analyzer may include a sample loading assembly 1, a sample absorbing assembly 2, and a detection assembly 3.

Wherein the sample loading assembly 1 is used for loading a sample collection container; the sample sucking assembly 2 is used for controlling the sample sucking needle to downwards extend to the sample collecting container so as to suck the sample to be detected in the sample collecting container; the detection component 3 is used for detecting a sample to be detected so as to obtain a detection result of the sample to be detected.

For loading the sample collection container, the sample loading assembly includes at least one detent for receiving the sample collection container. Alternatively, the sample loading assembly includes a sample rack 40 as shown in FIG. 4. The positioning slot 400 on the sample rack 40 is the positioning slot of the sample loading assembly.

In the sample analyzer, the sample loading assembly 1, the detection assembly 3 and the sample absorbing assembly 2 are arranged at intervals therein. The sample loading assembly 1 is located on the moving route of the sample sucking assembly 2, the detection assembly 3 can also be located on the moving route of the sample sucking assembly 2, so that the sample sucking needle is controlled by the sample sampling assembly 2 to move to the station where the sample loading assembly 1 is located, the sample collecting container is probed downwards to suck the sample to be detected, the sample sucking needle after sucking the sample to be detected is controlled to move to the station where the detection assembly 3 is located, and the sample to be detected is detected through the detection assembly. Or the detection component 3 is not required to be positioned on a motion route of the sample suction component 2, the sampling component 2 controls the sample suction needle to descend until the sample collection container sucks the sample to be detected, then the sample is injected into the detection container, and the detection container is scheduled to the detection component 3 for detection through the scheduling component; or, the sampling assembly 2 controls the sample sucking needle to descend until the sample collecting container sucks the sample to be detected, and then the sample to be detected is transferred to the detection assembly through the liquid path for detection.

The detection assembly may comprise an optical detection device or the like.

According to the detection requirement, the sample to be detected in the sample collection container can be a layered sample after centrifugal treatment or a collected whole blood sample.

The sample analyzer may further comprise a dispatch assembly and a centrifugation assembly, depending on the sample to be tested requiring centrifugation for re-detection. The dispatching component is used for dispatching the sample collection container to the centrifugal component; the centrifugal component is used for carrying out centrifugal treatment on the sample collection container so as to obtain a layered sample to be tested after centrifugation. The sample collection container after centrifugal treatment is placed to the sample loading assembly 1 by the scheduling assembly, the sampling assembly 2 controls the sample suction needle to move and then to descend until the sample collection container sucks the sample to be detected, and finally the sample to be detected is detected by the detection assembly 3.

The dispatch assembly may be configured with a robotic arm or the like.

When the sample analyzer is an immunoassay analyzer, it further comprises an incubation component and a magnetic separation component.

The incubation component is used for carrying out incubation treatment on liquid loaded by the reaction cup, and the liquid comprises a sample to be detected and a reagent which are sucked by the sample sucking component. In this regard, the sampling assembly 2 controls the sample suction needle to move to the sample collection container to suck the sample to be tested and the sucked reagent, and then the sucked reagent is injected into the reaction cup.

The magnetic separation component is used for carrying out magnetic separation treatment on the sample to be detected after incubation treatment; the sample to be detected after the magnetic separation treatment is detected by the detection component 3.

The sample absorbing assembly 2, the detecting assembly 3, the dispatching assembly, the incubating assembly and the magnetic separating assembly can be realized by adopting the prior art, for example, the incubating assembly can comprise a reaction disk for accommodating a reaction cup and providing an incubation environment, and the magnetic separating assembly can comprise a magnetic separating disk, a liquid injecting mechanism and the like, which are not described herein.

The foregoing description is only illustrative of the present utility model and is not intended to limit the scope of the utility model, and all equivalent structures or equivalent processes or direct or indirect application in other related technical fields are included in the scope of the present utility model.

Claims

1. A sample collection container comprising a sample collection tube; the sample collection tube comprises a transparent or semitransparent outer tube body and a sample storage tube suspended in the outer tube body;

2. The sample collection container of claim 1, wherein the bottom of the outer tube is open and the space between the inner surface of the outer tube and the outer surface of the sample storage tube communicates with the external environment through the open bottom.

3. The sample acquisition container of claim 1, wherein the inner diameter of the beveled tube segment tapers from the end to which the outer tube body is connected to the end to which the intermediate tube segment is connected.

4. The sample collection container of claim 1, wherein the outer surface of the cone segment is provided with at least one graduation mark for indicating volume; the scale marks are formed by annular bulges arranged on the outer surface of the taper pipe section.

5. The sample collection container of claim 4, wherein the exterior surface of the cone segment is provided with three graduation marks for indicating different volumes;

6. The sample collection container of any one of claims 1-5, further comprising a cap that seals against the top of the sample collection tube, closing the sampling port.

7. The sample collection container of claim 6, wherein the cap is provided with a sampling aperture in communication with the vial.

8. The sample collection container of claim 7, wherein a seal is disposed in the sampling aperture that extends radially to isolate the sampling aperture and is penetrable by a sampling needle.

9. The sample collection container of claim 7, wherein an annular wall surrounding the sampling aperture is provided within the cap, the annular wall being spaced apart from an inner peripheral wall surface of the cap by an annular space;

10. A centrifuge assembly for loading a sample collection container according to any one of claims 1 to 9; the sample collection container contains a sample to be tested;

11. A sample analyzer, comprising:

a sample loading assembly comprising at least one detent for receiving therein a sample collection container according to any one of claims 1-9;

12. The sample analyzer of claim 11, wherein a fixed column is disposed in the positioning slot, the fixed column is inserted into the outer tube of the sample collection container, and an outer surface of the fixed column is attached to an inner surface of the outer tube, so as to increase a capacitance change value of a sample liquid level in the sample storage tube.

13. The sample analyzer of claim 11, further comprising: a scheduling component and a centrifugation component;

14. The sample analyzer of claim 11, wherein the sample analyzer is an immunoassay analyzer, the sample analyzer further comprising: