KR20140053819A - 방사선요법용 177루테튬-표지 봄베신 유사체 - Google Patents

방사선요법용 177루테튬-표지 봄베신 유사체 Download PDF

Info

Publication number
KR20140053819A
KR20140053819A KR1020137016242A KR20137016242A KR20140053819A KR 20140053819 A KR20140053819 A KR 20140053819A KR 1020137016242 A KR1020137016242 A KR 1020137016242A KR 20137016242 A KR20137016242 A KR 20137016242A KR 20140053819 A KR20140053819 A KR 20140053819A
Authority
KR
South Korea
Prior art keywords
phe
gly
compound
seq
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020137016242A
Other languages
English (en)
Korean (ko)
Inventor
산드라 보르코우스키
로살바 만시
헬무트 메케
Original Assignee
피라말 이미징 에스에이
우니베르지테츠스피탈 바젤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 피라말 이미징 에스에이, 우니베르지테츠스피탈 바젤 filed Critical 피라말 이미징 에스에이
Publication of KR20140053819A publication Critical patent/KR20140053819A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13—Labelling of peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Radiation-Therapy Devices (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020137016242A 2010-11-22 2011-11-21 방사선요법용 177루테튬-표지 봄베신 유사체 Ceased KR20140053819A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10075743.4 2010-11-22
EP10075743 2010-11-22
PCT/EP2011/070553 WO2012069410A1 (en) 2010-11-22 2011-11-21 177lutetium-labeled bombesin analogs for radiotherapy

Publications (1)

Publication Number Publication Date
KR20140053819A true KR20140053819A (ko) 2014-05-08

Family

ID=45001762

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020137016242A Ceased KR20140053819A (ko) 2010-11-22 2011-11-21 방사선요법용 177루테튬-표지 봄베신 유사체

Country Status (16)

Country Link
US (1) US20140023585A1 (enExample)
EP (1) EP2643024A1 (enExample)
JP (1) JP2014500262A (enExample)
KR (1) KR20140053819A (enExample)
CN (1) CN103476434A (enExample)
AU (1) AU2011333948A1 (enExample)
BR (1) BR112013012503A2 (enExample)
CA (1) CA2818694A1 (enExample)
EA (1) EA026443B1 (enExample)
IL (1) IL226498A0 (enExample)
IN (1) IN2013MN01188A (enExample)
MX (1) MX2013005697A (enExample)
NZ (1) NZ610740A (enExample)
PH (1) PH12013501018A1 (enExample)
SG (1) SG190371A1 (enExample)
WO (1) WO2012069410A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2100900A1 (en) * 2008-03-07 2009-09-16 Universitätsspital Basel Bombesin analog peptide antagonist conjugates
PL2900279T3 (pl) 2012-09-25 2020-05-18 Advanced Accelerator Applications Usa, Inc. Antagonisty grpr do wykrywania, diagnostyki i leczenia raka grpr-pozytywnego
CN106039327A (zh) * 2016-06-14 2016-10-26 宁波益格爱生物科技有限公司 一种grpr靶向性分子探针及其制备方法
US20190358351A1 (en) * 2016-11-17 2019-11-28 Minerva Imaging Aps 177-lu labeled active site inhibited factor vii
US20250339567A1 (en) * 2019-12-19 2025-11-06 Technische Universität München Compounds with improved pharmacokinetics for imaging and therapy of cancer
EP4282439A1 (en) * 2022-05-23 2023-11-29 Erasmus University Rotterdam Medical Center Radioisotope labeled sstr2-agonists with linkers
CN117919452A (zh) * 2023-03-09 2024-04-26 中国科学院宁波材料技术与工程研究所 一种亚细胞器主动靶向成像探针及其制备方法
WO2025119203A1 (zh) * 2023-12-05 2025-06-12 烟台蓝纳成生物技术有限公司 一种异二聚体放射性核素偶联药物、制备及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2100900A1 (en) * 2008-03-07 2009-09-16 Universitätsspital Basel Bombesin analog peptide antagonist conjugates

Also Published As

Publication number Publication date
US20140023585A1 (en) 2014-01-23
EA201300611A1 (ru) 2014-04-30
CA2818694A1 (en) 2012-05-31
NZ610740A (en) 2015-08-28
PH12013501018A1 (en) 2017-08-23
IN2013MN01188A (enExample) 2015-07-10
BR112013012503A2 (pt) 2016-11-08
CN103476434A (zh) 2013-12-25
IL226498A0 (en) 2013-07-31
WO2012069410A1 (en) 2012-05-31
JP2014500262A (ja) 2014-01-09
EA026443B1 (ru) 2017-04-28
MX2013005697A (es) 2014-08-01
AU2011333948A1 (en) 2013-06-06
SG190371A1 (en) 2013-06-28
EP2643024A1 (en) 2013-10-02

Similar Documents

Publication Publication Date Title
RU2523531C2 (ru) Конъюгаты антагониста пептида аналога бомбезина
KR20140053819A (ko) 방사선요법용 177루테튬-표지 봄베신 유사체
WO2019075583A1 (en) NOVEL RADIOMETAL BINDING COMPOUNDS FOR THE DIAGNOSIS OR TREATMENT OF CANCER EXPRESSING A PROSTATE-SPECIFIC MEMBRANE ANTIGEN
AU2019273132A1 (en) Radiolabeled melanocortin 1 receptor-specific alpha-melanocyte-stimulating hormone analogues for imaging or therapy
JP2020522557A (ja) 診断及び治療のための、改善された薬物動態及びコレシストキニン−２受容体（ｃｃｋ２ｒ）への標的化
CN114364690A (zh) 用于诊断和治疗的新型放射性标记的cxcr4靶向化合物
ES2651334T3 (es) Péptidos marcados con tecnecio
Bugaj et al. Radiotherapeutic efficacy of 153Sm-CMDTPA-Tyr3-octreotate in tumor-bearing rats☆
CN116472068A (zh) 治疗性放射性标记的缀合物及其在疗法中的用途
CA2464002C (en) Pacap compositions and methods for tumor imaging and therapy
US20230270893A1 (en) Gallium-labeled gastrin analogue and use in a method of imaging cckb-receptor-positive tumors or cancers
KR20230078690A (ko) 가스트린 방출 펩타이드 수용체 길항제를 포함하는 접합체 또는 이의 염 및 이의 용도
KR20220118464A (ko) 암의 영상화 및 치료법을 위한 개선된 약동학을 갖는 화합물
HK1192487A (en) 177 lutetium-labeled bombesin analogs for radiotherapy
KR101658206B1 (ko) 전립선암의 진단 및 치료를 위한 가스트린유리펩티드수용체 길항서열 기반의 신규한 봄베신 유도체 화합물
US9827338B2 (en) GRP-R agonistic 177-lutetium-labeled bombesin derivatives for diagnosis and treatment of prostate cancer
WO2024245421A1 (en) Radioligands for targeting cell surface receptors and uses thereof
JP2005068046A (ja) ソマトスタチンアナログ誘導体およびその利用
CN119072485A (zh) 用于羟基磷灰石靶向显像和治疗的缀合物、组合物和方法
RU2821944C2 (ru) Антагонисты grpr для обнаружения, диагностики и лечения grpr-позитивного онкологического заболевания
Pinto Organometallic Complexes of Tc I and Re I for Radiometalation of Biologically Active Peptides
AU2002342104A1 (en) PACAP compositions and methods for tumor imaging and therapy

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20130621

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20161121

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20180503

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20180720

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20180503

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I