KR20140018725A - Composition for improving condition of hair and scalp containing extract of soybean pod - Google Patents

Abstract

The present invention relates to a composition for preventing hair loss, promoting hair growth, and protecting scalp containing an extract of soybean pods as an effective component. The composition contains 0.001-10 wt% of extract of soybean pods for the total amount of the composition. The composition reduces the stimulation on scalp.

Description

Composition for improving condition of hair and scalp containing extract of soybean pod}

The present invention relates to a composition for preventing hair loss or promoting hair growth or scalp protection comprising a bean pod extract.

Hair loss is a problem that occurs through natural processes or is chemically promoted through the use of certain therapeutic drugs designed to alleviate symptoms such as cancer. This hair loss involves the lack of hair regrowth that causes partial or complete baldness.

Recently, as more modern people have alopecia due to environmental pollution, stress, diet, fatigue, and incorrect eating habits, interest in substances that can improve them is increasing. In order to prevent hair loss and promote hair growth, it has been a challenge in the art to find a material that can protect the scalp.

The present inventors have confirmed that the composition containing the bean pod extract has hair loss prevention or wool promotion or scalp protection effect and completed the present invention.

Fathke et al., "Wnt signaling induces epithelial differentiation during cutaneous wound healing", BMC Cell Biology 2006, 7: 4

It is an object of the present invention to provide a composition comprising a natural extract that can be used to prevent hair loss or promote hair growth or protect the scalp.

In order to achieve the above object, the present invention provides a composition for preventing hair loss or promoting wool comprising the bean pod extract as an active ingredient.

The present invention also provides a composition for protecting the scalp comprising a bean pod extract as an active ingredient.

The composition of the present invention can relieve skin irritation, relieve itching and reduce dandruff, thereby protecting the scalp. In addition, the composition of the present invention can proliferate all hair follicles and act as an opener of potassium ion channels, thereby promoting wool and preventing hair loss. In particular, the composition of the present invention shows a better effect than soybean extract in preventing hair loss or promoting wool or protecting the scalp. The compositions of the present invention also contain very little irritation to organisms, including extracts of natural origin obtained from natural products.

In the present specification, 'bean' is not limited in kind. In the composition which is one aspect of the present invention, specifically, the soybean of the present specification is selected from the group consisting of frosted, seomoktae, heuktae, chungtae, yellow, hedge bean, kidney bean, zebra kidney bean, red bean, soybean, bean sprout bean and soybean It may include any one or more, but is not limited thereto.

In the present specification, the 'bean pod' means a shell containing the bean, that is, the shell surrounding the bean.

In the present specification, 'bean pod extract' is, for example, in the extraction process, washed and dried bean pods or powdered soybean pod powder in water or an organic solvent, extracted and deposited, and then filtered through filter cloth and centrifugation. The residue and the filtrate are separated, and the filtrate is concentrated under reduced pressure to obtain a bean pod extract. The organic solvent usable in the present invention may be selected from ethanol, methanol, butanol, ether, ethyl acetate, chloroform or a mixed solvent of these organic solvents and water, and considering the safety of the raw material, preferably water or 30 to 70% concentration. Ethanol is used. After obtaining the extract using a solvent in the above can be obtained by cooling, heating and filtration at room temperature in a conventional manner known in the art to obtain a liquid, or may further evaporate the solvent, spray drying or freeze drying, but The present invention is not limited thereto, and any method generally used in the art may be used without limitation.

The present invention relates to a hair loss preventing or wool promoting composition comprising a bean pod extract as an active ingredient in one aspect.

In the present specification, "hair" is a general term for body hair and hair, and may also be described as hair. The hair includes both human and animal hair.

As used herein, "hair promotion" means not only promoting the production of new hair, but also allowing existing hair to grow thick and healthy.

Specifically, in the composition of one aspect of the present invention, the composition may relieve skin irritation, reduce dandruff and relieve skin itching to prevent hair loss or promote wool. The composition may also prevent hair loss or promote wool by activating the potassium ion channel to propagate all hair follicle cells or as an opener of potassium ion channels.

In another aspect, the present invention relates to a scalp protective composition comprising a bean pod extract as an active ingredient.

Specifically, in the composition which is one aspect of the present invention, the composition can relieve skin irritation, especially skin itching, and reduce dandruff. Therefore, the composition can be usefully used for the treatment of diseases such as atopic dermatitis, psoriasis accompanied by itching of the skin.

In one aspect of the present invention, the composition may comprise 0.001 to 10% by weight of the bean pod extract based on the total weight of the composition.

If the content of the bean pod extract is less than 0.001% by weight based on the total weight of the composition, the hair loss prevention or wool promoting effect or the scalp protection effect is insignificant, and when the content exceeds 10% by weight, there is no apparent increase in the content increase. In view of the above, the composition of the present invention, 0.005 to 9.5% by weight, 0.01 to 9% by weight, 0.03 to 8.5% by weight, 0.05 to 8% by weight, 0.07 to 7.5% by weight, 0.09 to the total weight of the composition It may include 7% by weight, 0.1 to 6.5% by weight, 0.3 to 6% by weight, 0.5 to 5.5% by weight or 0.7 to 5% by weight of the bean pod extract.

In the composition of one aspect of the invention, the soybean is Seoritae ( Glycin max MERR), Seomoktae (Seomoktae, Rhynchosia Nolubilis ), Black soybean, Glycine max (L.) Merr.), Cheongtae (blue bean, Glycime) max MERR), yellow bean, Glycime max MERR), field bean, Vicia faba ), Kidney bean ( Phaseolus) vulgaris , pinto bean, Phaseolus vulgaris L.), small red bean, Vigna angularis ), Soybeans (small black bean, Phaseolus angularis WF WIGHT.), Sprouting bean, Glycine max (L.) Merr.) and soybean ( Glycine) max ) and any one or more selected from the group consisting of.

In a composition which is one aspect of the present invention, the composition may relieve scalp irritation.

In a composition of one aspect of the present invention, the composition may reduce dandruff.

In one aspect of the invention, the composition comprises a cosmetic composition.

Specifically, the cosmetic composition of the present invention may have a conventional formulation, for example, it may be formulated as a shampoo, rinse, hair tonic, pomade, hair treatment, hair lotion and the like. The hair cosmetic composition of each of these formulations may contain a variety of ingredients that are formulated into conventional hair cosmetic compositions according to the various formulations described above or as appropriate for the end purpose, and the types and amounts of these components can be easily selected by those skilled in the art. have.

When the composition according to the present invention is formulated in the form of cosmetics, in the form of softening cream, astringent makeup, nutrition cream, eye cream, nutrition cream, massage cream, cleansing cream, cleansing foam, cleansing water, powder, essence or pack It may be formulated as, and the formulation is not particularly limited. In addition, the composition according to the present invention can also be used as a lubricant, an organic solvent, a solubilizer, a thickening agent, a gelling agent, a softening agent, an antioxidant, a suspending agent, a stabilizer, a foaming agent, a fragrance, The active ingredient may be combined with any other ingredients commonly used in cosmetics, such as ionic emulsifiers, fillers, sequestering agents, chelating agents, preservatives, vitamins, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, And may contain adjuvants commonly used in the same cosmetic or dermatological fields. Such adjuvants are introduced in amounts commonly used in the cosmetics or dermatological fields. In addition, the composition of the present invention may contain a skin absorption promoting substance to increase the skin improving effect.

The cosmetic composition according to the present invention may contain, in addition to the above-mentioned substances, other ingredients which can give a synergistic effect to the main effect, so long as they do not impair the main effect. The cosmetic composition according to the present invention may further comprise a moisturizing agent, an emollient agent, an ultraviolet absorber, an antiseptic, a bactericide, an antioxidant, a pH adjuster, an organic and inorganic pigment, a fragrance, a cold agent or a limiting agent. The blending amount of the above components can be easily selected by those skilled in the art within the range that does not impair the object and effect of the present invention, the blending amount may be 0.01 to 5% by weight, specifically 0.01 to 3% by weight based on the total weight of the composition. have.

In one aspect of the invention, the composition comprises a pharmaceutical composition.

When the composition according to the present invention is applied to medicines, it may be formulated into an oral or parenteral dosage form in the form of solid, semi-solid or liquid by adding an inorganic or organic carrier to the composition as an active ingredient.

Examples of the agent for oral administration include tablets, pills, granules, capsules, powders, fine granules, powders, emulsions, syrups and pellets. In addition, preparations for parenteral administration include injections, drops, ointments, lotions, sprays, suspensions, emulsions, suppositories, patches, and the like. In order to formulate the active ingredient of the present invention, it can be easily formulated according to the conventional method. Surfactants, excipients, coloring agents, spices, preservatives, stabilizers, buffering agents, suspending agents and other adjuvants can be suitably used.

The pharmaceutical composition according to the present invention may be administered orally, parenterally, rectally, topically, transdermally, intravenously, intramuscularly, intraperitoneally, subcutaneously and the like.

The effective ingredients of the pharmaceutical composition of the present invention will vary depending on the age, sex, weight, pathological condition and severity of the subject to be treated, administration route or judgment of the prescriber. Determination of the amount of application based on these factors is within the level of ordinary skill in the art and its daily dose is, for example, from 0.1 mg / kg / day to 100 mg / kg / day, more specifically from 5 mg / kg / day to 50 mg / / Day, but is not limited thereto.

In one aspect of the invention, the composition comprises a health food composition.

The composition according to the invention provides various types of food additives or functional foods comprising. Fermented milk, cheese, yogurt, juice, probiotic, tablets, granules, drinks, caramels, diet bars and the like containing the composition, and can be processed into conventional tea leaf form or tea bags and dietary supplements. And other various food additives.

In one embodiment, the composition may contain other ingredients and the like that can give a synergistic effect to the main effect within a range that does not impair the main effect of the present invention. For example, additives such as perfume, coloring agent, bactericide, antioxidant, preservative, moisturizing agent, thickening agent, inorganic salt, emulsifier and synthetic polymer substance may be further added for improvement of physical properties. In addition, supplementary ingredients such as water soluble vitamins, oil soluble vitamins, polymer peptides, polymer polysaccharides and seaweed extract may be further included. The above components may be mixed and selected without difficulty by those skilled in the art depending on the purpose of formulation or use, and the amount thereof may be selected within a range that does not impair the objects and effects of the present invention. For example, the addition amount of the above components may be in the range of 0.01 to 5% by weight, more specifically 0.01 to 3% by weight, based on the total weight of the composition.

The composition according to the present invention may be in various forms such as a solution, an emulsion, a viscous mixture, a tablet, a powder, etc., and may be administered by various methods such as simple drinking, injection administration, spraying or squeezing.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are only for illustrating the present invention and that the scope of the present invention is not construed as being limited by these embodiments.

[ Manufacturing example  1] Preparation of Bean Pod Extract

1.5 kg of bean pods were pulverized with a blender, and 7 L of an 80% ethanol aqueous solution was added thereto, followed by extraction under reflux three times, followed by immersion at 15 ° C. for 1 day. Thereafter, the residue and the filtrate were separated through filter cloth filtration and centrifugation. The separated filtrate was concentrated under reduced pressure to obtain 252 g of bean pod extracts.

[ Comparative Example  1] Preparation of Soybean Extract

1.5 kg of beans were pulverized with a blender, and 7 L of an 80% ethanol aqueous solution was added thereto, followed by extraction under reflux three times, followed by immersion at 15 ° C. for 1 day. Thereafter, the residue and the filtrate were separated through filter cloth filtration and centrifugation. The separated filtrate was concentrated under reduced pressure to obtain 343 g of a soybean extract.

[ Example  1 to 4 and Comparative Example  2, 3] Preparation of Shampoo

To prepare a shampoo in the component and composition ratio shown in Table 1.

Specifically, the surfactant and ethylene glycol distearate are added to purified water, heated to 80 ° C., uniformly dissolved, and then slowly cooled to 40 ° C. under stirring, and the bean pod extract according to the present invention is added to the mixture. A preservative, a viscosity modifier, a fragrance, and a hair conditioner were added and mixed, followed by cooling to room temperature under stirring.

ingredient Example 1 Example 2 Example 3 Example 4 Comparative Example 2 Comparative Example 3 Ammonium Lauryl Sulfate 10 10 10 10 10 10 Polyoxyethylene lauryl ammonium sulfate 5 5 5 5 5 5 Cocoamidopropylbetaine 2 2 2 2 2 2 Ethylene Glycol Distearate 1.5 1.5 1.5 1.5 1.5 1.5 Cocoyl Monoethanolamide 0.8 0.8 0.8 0.8 0.8 0.8 Bean pod extract 1.0 2.0 3.0 5.0 - - Bean extract - - - - 5.0 - Polyquaternium-10 0.2 0.2 0.2 0.2 0.2 0.2 Blue No. 1 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 Yellow No. 4 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 Methylparaben 0.1 0.1 0.1 0.1 0.1 0.1 Spices 0.8 0.8 0.8 0.8 0.8 0.8 Citric acid 0.1 0.1 0.1 0.1 0.1 0.1 Dimethicone 1.0 1.0 1.0 1.0 1.0 1.0 water to 100 to 100 to 100 to 100 to 100 to 100

[ Test Example  1] Stimulation relief efficacy test

MEST method using a mouse was applied to evaluate the stimulation relaxation effect by shampoo stimulation, and the test method was as follows.

A 6-week-old BALB / c mouse was purchased and the test system was constructed with a 10-day quarantine and adaptation period. Hair was removed from the abdomen of the rat, and 2.5% paraphenylenediamine (PPD) was applied for 3-5 days. After a week of rest, the shampoo was applied to the rats' ears and wiped off after 30 minutes. After having a rest period of one week again, the compositions of Examples 1 to 4 and Comparative Examples 2 and 3 were applied twice at an hourly interval. The shampoo was applied again and after 24 hours, the above Examples 1 to 4 and Comparative Examples 2 and 3 were applied twice. After 24 hours, the weight of the ear was measured, and the weight of the pathological tissue was measured by H & E staining. The measurement results are shown in Table 2 below.

Ear weight (mg) Ear thickness (μm) Example 1 9.83 ± 0.91 277.42 ± 24.52 Example 2 9.61 ± 0.84 253.24 ± 22.61 Example 3 9.22 ± 0.99 249.98 ± 24.32 Example 4 8.16 ± 1.65 238.54 ± 29.85 Comparative Example 2 12.90 ± 1.04 431.13 ± 5.473 Comparative Example 3 14.90 ± 1.609 454.26 ± 11.583

As can be seen in Table 2, when the pretreatment with the compositions of Examples 1 to 4 according to the present invention it was confirmed that the ear weight and ear thickness significantly decreased. In addition, when treated with the compositions of Examples 1 to 4 compared to Comparative Example 2 was able to confirm a more excellent effect. It can be seen that the composition for improving hair and scalp condition according to the present invention has an effect of relieving inflammation caused by shampoo.

[ Test Example  2] Antidandruff  evaluation

The antidandruff force of Examples 1 to 4 and Comparative Examples 2 and 3 were measured and compared. At this time, the test strain is dandruff Pytirosporum Ovale ( Pityrosporum) Ovalae (ATCC 12078)) was used. Antibacterial activity was measured by the skin disk diffusion method. The skin disc diffusion method (SDDM) is a method that is closest to a consumer's habit of use, and is a method of measuring antimicrobial activity on guinea pig skin similar to human skin. Specifically, after peeling off the guinea pig skin (70% ethanol treatment) to uniformly dry by using a ethanol, the cut skin disk was used to cut to a certain size. The sterilized skin discs were soaked in dilute shampoo solution for 3 minutes and then washed with running water. Then, the skin disk was placed on a solid medium inoculated with the test bacteria and then cultured. After incubation, the relative antimicrobial activity was measured by measuring the size of the clear zone in which the growth of bacteria was suppressed. The experimental results are shown in Table 3 below as average values of the results of three measurements.

division Inhibitor size (mm) Example 1 Example 2 Example 3 Example 4 Comparative Example 2 Comparative Example 3 Dandruff inhibitor ring size 3.2 3.5 4.5 4.9 1.1 0

Looking at Table 3, in the case of Comparative Example 3 containing no bean pod extract, there is no dandruff reduction effect, but in the case of Examples 1 to 4 containing the bean pod extract effectively reduced dandruff. In addition, compared to Comparative Example 2 Examples 1 to 4 it was found that even more excellent dandruff reduction effect.

[ Test Example  3] dandruff reduction effect test

72 men aged 19-35 years old who had a lot of dandruff were selected to use the shampoos of Examples 1 to 4 and Comparative Examples 2 and 3 in six groups of 12 people for one month as follows. Was measured.

Trituration with a normal shampoo before the start of the test, and collected the dandruff accumulated for 2 days after the tricycle, the weight of the collected dandruff and trituration once every two days with the shampoo of each of Examples 1 to 4 and Comparative Examples 2 and 3 The weight of the dandruff accumulated for 2 days was compared and evaluated. At this time, the accumulated dandruff was collected directly from the scalp with a vacuum suction device, to obtain a rate of dandruff reduction based on Equation 1 below and the results are shown in Table 4 below.

[Equation 1]

Example 1 Example 2 Example 3 Example 4 Comparative Example 2 Comparative Example 3 Dandruff reduction rate
(%) 56.18 74.66 78.65 84.74 6.74 0.7 71.3 60.59 82.32 86.42 8.55 -0.5 54.6 72.98 64.79 92.93 6.55 -1.1 54.29 63.63 86.73 79.91 6.51 1.5 62.27 55.55 83.79 73.71 7.47 2.2 71.93 68.15 75.29 86.42 8.63 1.3 52.61 63.11 69.3 78.96 6.31 6.3 71.19 66.05 66.57 79.07 8.54 3.6 55.97 67.52 78.96 89.78 6.71 3.3 63.11 59.64 82.53 90.41 7.57 4.6 64.47 69.83 78.12 84.42 7.73 3.7 54.39 73.92 70.14 79.49 6.52 4.2 medium 61.03 66.30 76.43 83.86 7.32 2.48 SD 7.36 6.03 7.20 5.71 0.88 2.19

As can be seen in Table 4, Examples 1 to 4 containing the bean pod extract can be seen to exhibit an excellent anti-dandruff effect. In addition, it can be seen that it shows a more excellent anti-dandruff effect compared to Comparative Example 2 containing soy extract.

[ Test Example  4] Scalp Itching Prevention Test

72 men and women aged 25-45 who feel severely itching scalp were divided into 6 groups of 12 people, and the shampoos of Examples 4 and Comparative Examples 2 and 3 were used once every 3 days for 2 weeks. The anti-itch effect was evaluated through the following evaluation criteria and the results are shown in Table 5 below.

[Evaluation standard]

Very good-5 points

Excellent-4 points

Normal-3 points

Poor-2 points

Very bad-1 point

division Example 1 Example 2 Example 3 Example 4 Comparative Example 2 Comparative Example 3 Itching effect of scalp 3.3 3.5 4.1 4.8 2.5 2.3

As can be seen in Table 5, it can be seen that the case of Examples 1 to 4 containing the bean pod extract showed a better effect in preventing scalp itch. In addition, it can be seen that compared to Comparative Example 2 containing soybean extract exhibits a superior scalp itching effect.

[ Test Example  5] hair follicles Dairy cattle  Cell proliferation effect

The keratin proteins that make up hair are produced in hair root keratinocytes, which are differentiated from dermal papilla cells. In order to evaluate the activity of the dermal papilla cells of the composition, a rat immortalized dermal papilla cell (DP6) cell line was used in the present invention (Wendy Filsell, Journal of Cell Science 107, 1761-1772 (1994)). This dermal papilla cell line was cultured by microdissection from the hair roots of male PVG rat whiskers and cultured with DMEM (Dulbecco's modified Eagle's medium, Gibco BRL, Gaithersburg, MD, USA) was incubated for 24 hours in an incubator maintained at 5% CO2, 37 ℃. DP6 was placed in a 96 well plate and incubated in a 37 ° C. incubator for 24 hours, and then the bean pod extracts were treated at concentrations of 10 ppm, 50 ppm and 100 ppm, respectively. After 24 hours of drug treatment, cell proliferation was measured using the WST-1 kit (Roche). The results are shown in Table 6 below.

division Cell proliferation (%) Untreated Control 100 Bean pod extract (10ppm) 112 Bean pod extract (50ppm) 127 Bean pod extract (100ppm) 148 Soybean Extract (10 ppm) 101 Soybean Extract (50 ppm) 105 Soybean Extract (100 ppm) 112

As can be seen in Table 6, when the bean pod extract is treated, the growth of the dermal papilla cells increases, which can be confirmed to increase significantly in a concentration-dependent manner. In addition, the proliferative effect of the dermal papilla cells can be confirmed more than when the soy extract was treated.

[ Test Example  6] Evaluation of the effect of increasing potassium ion channel activity

Minoxidil, a hair loss treatment agent, is known as a potential mitochondrial potassium ion channel opener and is a representative drug used to treat androgenetic hair loss. In order to evaluate the mechanism of minoxidil, the treatment of toltamide (SIGMA AlDRICH, T0891), which blocks KATP channels, in fibroblasts constituting the dermis of the scalp, inhibits cell proliferation, and opens potassium ion channels to restore cell proliferation. Test method was used.

In order to evaluate the function of the composition as a KATP channel opener, in the present invention, a mouse embryonic fibroblast cell line (NIH3T3) cell line was used. The cell line is a cell line in which the fibroblast cell line isolated from NIH Swiss mouse embryo was naturally immortalized by 3T3 protocol. The cell line was incubated in DMEM (Gibco BRL, Gaithersburg, MD, USA) containing 10% FBS for 24 hours in an incubator maintained at 5 ° C. CO 2, 37 ° C. NIH3T3 was placed in a 96-well plate and incubated in a 37 ° C. incubator for 24 hours, followed by 2.5 mM tolbutamide treatment. After 48 hours of drug treatment, cell proliferation was measured using the WST-1 kit (Roche). The results are shown in Table 7 below.

division Cell proliferation (%) Untreated Control (Control) 100 Minoxidil 133 Bean pod extract (10ppm) 114 Bean pod extract (50ppm) 123 Bean pod extract (100ppm) 135 Soybean Extract (10 ppm) 102 Soybean Extract (50 ppm) 105 Soybean Extract (100 ppm) 106

As can be seen in Table 7, the treatment of soybean pod extract recovers the growth of fibroblasts, the cell proliferation ability can be seen by increasing the concentration-dependent increase of the treated soybean pod extract, and treated with 100ppm soybean pod extract In one case it can be seen that the growth of fibroblasts to minoxidil levels. In addition, when treated with soybean pod extract compared to the case of the soybean extract it was confirmed that the better proliferation of fibroblasts.

[ Example  5 and Comparative Example  4, 5]

To prepare a composition of the cream formulation in a conventional manner according to the composition of Table 8 (unit: wt%).

Compounding ingredient Example 5 Comparative Example 4 Comparative Example 5 Labrafac 23 23 23 Tween 80 10.5 10.5 10.5 Glycerol monostearate 4.0 4.0 4.0 Stearic acid 7.0 7.0 7.0 Cetyl alcohol 2.0 2.0 2.0 Propylene glycol 9.0 9.0 9.0 Glycerol Monooleate 3.5 3.5 3.5 Bean pod extract One - - Bean extract - One - water 40 40 41

[ Test Example  7] Wool Effect of Soybean Pod Extract

After the hair on the back of the ICR mouse was depilated with a hair remover, hair was completely removed using a hair removal cream (beet cream). The skin inflammation was induced for 3 days by applying 200 μl once daily to the skin with 1% DNCB for the other 2 groups except the control group (normal group). By inducing skin inflammation in this manner to set the stress conditions in the skin to reduce the growth of the hair to the maximum, and to evaluate the hair regeneration efficacy of the composition of the present invention, Example 5 and Comparative Example 2 containing the bean pod extract , 3 creams were treated, and hair length was measured according to the treatment days and compared with the control group. The results are shown in Table 9 below.

Days of Treatment (Days) Hair length (cm) Example 5 Treatment Comparative Example 4 Treatment Comparative Example 5 Treatment 0 0.1 0.1 0.1 6 0.2 0.1 0.1 9 0.5 0.2 0.1 12 0.9 0.3 0.1

Referring to Table 9, the length of the hair of the group treated with the cream formulation of Example 5 showed a statistically significant difference (p <0.01) compared to the group treated with the cream substrates of Comparative Examples 4 and 5, and the number of treatment days In the case of day 12, the length was increased to about 0.9 cm, and the cream base of Example 5 was treated in comparison with the group treated with the cream base of Comparative Examples 4 and 5 containing no bean pod extract. You can see that the hair is longer.

It is determined that the bean pod extract promotes hair regeneration even under the condition of inhibiting hair regeneration formed under skin stress, and it can be seen that the bean pod extract has a regenerating function for hair that has been bald under stress. In addition, it can be seen that the bean pod extract has a better regeneration function for hair loss compared to the soybean extract.

Hereinafter, the formulation examples of the composition according to the present invention, but the pharmaceutical composition and cosmetic composition is applicable to a variety of formulations, which is intended to explain in detail only, not intended to limit the present invention.

[Formulation Example 1] Soft capsule

Soybean pod extract 150 mg, palm oil 2 mg, palm hardened oil 8 mg, lead 4 mg and lecithin 6 mg were mixed and 400 mg per capsule was prepared according to a conventional method to prepare a soft capsule.

[Formulation Example 2] Tablets

Bean pod extract 150 mg, glucose 100 mg, red ginseng extract 50 mg, starch 96 mg and magnesium stearate 4 mg were mixed and 30 mg of ethanol was added to form granules, and then dried at 60 ° C. using a tablet press. Tableting.

[Formulation Example 3] Granules

Soybean pod extract 150 mg, glucose 100 mg, red ginseng extract 50 mg and starch 600 mg were mixed and granules were formed by adding 100 mg of 30% ethanol, dried at 60 ° C. to form granules, and then filled into sachets. The final weight of the contents was 1 g.

[Example 4] Drinks

Bean pod extract 150 mg, glucose 10 g, red ginseng extract 50 mg, citric acid 2 g and purified water 187.8 g was mixed and filled with a bottle. The final dose of the contents was 200 ml.

[Formulation Example 5] Preparation of health food

Bean pod extract ............................. 1000 mg

Vitamin mixture

Vitamin A Acetate ......... 70 μg

Vitamin E ............................................ 1.0 mg

Vitamin B1 ........................................... 0.13 mg

Vitamin B2 .......................................... 0.15 mg

Vitamin B6 ......................................... 0.5 mg

Vitamin B12 ......................... 0.2 μg

Vitamin C ............................................. 10 mg

Biotin ... 10 ㎍

Nicotinic acid amide .................................. 1.7 mg

Folic acid ................................................. ..... 50 μg

Calcium pantothenate .................................... 0.5 mg

Mineral mixture

Ferrous Sulfate ......................................... 1.75 mg

Zinc oxide ............................................ 0.82 mg

Magnesium carbonate ...................................... 25.3 mg

Potassium Phosphate ......................................... 15 mg

Secondary calcium phosphate ...................................... 55 mg

Potassium citrate ............................................ 90 mg

Calcium carbonate .............................................. 100 mg

Magnesium chloride ..................................... 24.8 mg

Although the composition ratio of the above-mentioned vitamin and mineral mixture is comparatively mixed with a composition suitable for health food as a preferred embodiment, the compounding ratio may be arbitrarily modified, and the above ingredients are mixed according to a conventional method for producing healthy foods , Granules can be prepared and used in the manufacture of health food compositions according to conventional methods.

Preparation Example 6 Preparation of Healthy Drinks

Bean pod extract .................. 1000 mg

Citric acid ................................................. ... 1000 mg

oligosaccharide................................................. .... 100 g

Plum concentrate ................................................ ..... 2 g

Taurine ................................................. ........... 1 g

Purified water was added to the mixture to complete 900 ml

The above components were mixed according to a conventional health drink manufacturing method, and the mixture was heated at 85 DEG C for about 1 hour with stirring, and the solution thus prepared was filtered to obtain a sterilized 2-liter container, which was sealed and sterilized, &Lt; / RTI &gt;

Although the composition ratio is mixed with a component suitable for a favorite beverage in a preferred embodiment, the compounding ratio may be arbitrarily modified according to regional and ethnic preferences such as demand hierarchy, demand country, and use purpose. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.

[Formulation Example 1] Softening lotion (skin lotion)

Compounding ingredient Content (% by weight) Bean pod extract 0.1 glycerin 3.0 Butylene glycol 2.0 Propylene glycol 2.0 Carboxyvinyl polymer 0.1 Phage-12 nonylphenyl ether 0.2 Polysorbate 80 0.4 ethanol 10.0 Triethanolamine 0.1 Preservative, coloring, fragrance Suitable amount Purified water Balance

[Formulation Example 2] Nutritional lotion (Milk lotion)

Compounding ingredient Content (% by weight) Bean pod extract 0.1 glycerin 3.0 Butylene glycol 3.0 Propylene glycol 3.0 Carboxyvinyl polymer 0.1 Wax 4.0 Polysorbate 60 1.5 Caprylic / capric triglyceride 5.0 Squalane 5.0 Sorbitacecequioleate 1.5 Liquid paraffin 0.5 Cetearyl alcohol 1.0 Triethanolamine 0.2 Preservative, coloring, fragrance Suitable amount Purified water Balance

[Formulation Example 3] Nourishing cream

Compounding ingredient Content (% by weight) Bean pod extract 0.1 glycerin 3.0 Butylene glycol 3.0 Liquid paraffin 7.0 Beta Glucan 7.0 Carbomer 0.1 Caprylic / capric triglyceride 3.0 Squalane 5.0 Cetearyl glucoside 1.5 Sorbitan stearate 0.4 Polysorbate 60 1.2 Triethanolamine 0.1 Preservative, coloring, fragrance Suitable amount Purified water Balance

[Formulation Example 4] Massage cream

Compounding ingredient Content (% by weight) Bean Pod Extract 0.1 glycerin 8.0 Butylene glycol 4.0 Liquid paraffin 45.0 Beta Glucan 7.0 Carbomer 0.1 Caprylic / capric triglyceride 3.0 Wax 4.0 Cetearyl glucoside 1.5 Sesquioleic acid sorbitan 0.9 Vaseline 3.0 paraffin 1.5 Preservative, coloring, fragrance Suitable amount Purified water Balance

[Formulation Example 5] Pack

Compounding ingredient Content (% by weight) Bean pod extract 0.1 glycerin 4.0 Polyvinyl alcohol 15.0 Hyaluronic acid extract 5.0 Beta Glucan 7.0 Allantoin 0.1 Nonyl phenyl ether 0.4 Polysorbate 60 1.2 Ethanol preservative 6.0 Good Preservative, coloring, fragrance Suitable amount Purified water Balance

[Formulation Example 6] ointment

Compounding ingredient Content (% by weight) Bean pod extract 0.1 glycerin 8.0 Butylene glycol 4.0 Liquid paraffin 15.0 Beta Glucan 7.0 Carbomer 0.1 Caprylic / capric triglyceride 3.0 Squalane 1.0 Cetearyl glucoside 1.5 Sorbitan stearate 0.4 Cetearyl alcohol 1.0 Wax 4.0 Preservative, coloring, fragrance Suitable amount Purified water Balance

Formulation Example 7 Shampoo

Compounding ingredient Content (% by weight) Ammonium Lauryl Sulfate 10 Polyoxyethylene lauryl ammonium sulfate 5 Cocoamidopropylbetaine 2 Ethylene Glycol Distearate 1.5 Cocoyl Monoethanolamide 0.8 Bean pod extract 5.0 Polyquaternium-10 0.2 Blue No. 1 0.0002 Yellow No. 4 0.0001 Methylparaben 0.1 Spices 0.8 Citric acid 0.1 Dimethicone 1.0 water to 100

While the present invention has been particularly shown and described with reference to specific embodiments thereof, those skilled in the art will readily appreciate that many modifications are possible in the exemplary embodiments without materially departing from the novel teachings and advantages of this invention. something to do. Accordingly, the actual scope of the present invention will be defined by the appended claims and their equivalents.

Claims (9)

Hair loss prevention or wool promotion composition comprising soybean pod extract as an active ingredient. Scalp protection composition comprising soybean pod extract as an active ingredient. The composition of claim 1 or 2, wherein the composition comprises from 0.001 to 10% by weight of bean pod extract based on the total weight of the composition. According to claim 1 or 2, wherein the soybean (Seoritae, Glycin max MERR), Seomoktae ( Rhynchosia Nolubilis ), Black soybean, Glycine max (L.) Merr.), Cheongtae (blue bean, Glycime) max MERR), yellow bean, Glycime max MERR), field bean, Vicia faba ), Kidney bean ( Phaseolus) vulgaris , pinto bean, Phaseolus vulgaris L.), small red bean, Vigna angularis ), Soybeans (small black bean, Phaseolus angularis WF WIGHT.), Sprouting bean, Glycine max (L.) Merr.) and soybean ( Glycine) max ) any one or more composition selected from the group consisting of. The composition of claim 1 or 2, wherein the composition alleviates scalp irritation. The composition of claim 1 or 2, wherein the composition reduces dandruff. The composition of claim 1 or 2, wherein the composition is a cosmetic composition. The composition of claim 1 or 2, wherein the composition is a pharmaceutical composition. The composition of claim 1 or 2, wherein the composition is a health food composition.