KR20130123301A - 히스톤 디아세틸라아제의 저해제들로서 유용한 거대고리 화합물들 - Google Patents

히스톤 디아세틸라아제의 저해제들로서 유용한 거대고리 화합물들 Download PDF

Info

Publication number
KR20130123301A
KR20130123301A KR1020127033908A KR20127033908A KR20130123301A KR 20130123301 A KR20130123301 A KR 20130123301A KR 1020127033908 A KR1020127033908 A KR 1020127033908A KR 20127033908 A KR20127033908 A KR 20127033908A KR 20130123301 A KR20130123301 A KR 20130123301A
Authority
KR
South Korea
Prior art keywords
cycloalkyl
alkyl
heterocycloalkyl
independently
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
KR1020127033908A
Other languages
English (en)
Korean (ko)
Inventor
슈에동 리우
앤드류 제이 필립스
다나 언절먼노바
크리스토퍼 지 나스베척
간 장
Original Assignee
더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 filed Critical 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트
Publication of KR20130123301A publication Critical patent/KR20130123301A/ko
Abandoned legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
KR1020127033908A 2010-05-27 2011-05-26 히스톤 디아세틸라아제의 저해제들로서 유용한 거대고리 화합물들 Abandoned KR20130123301A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34897810P 2010-05-27 2010-05-27
US61/348,978 2010-05-27
PCT/US2011/038246 WO2011150283A1 (en) 2010-05-27 2011-05-26 Macrocyclic compounds useful as inhibitors of histone deacetylases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020187018653A Division KR102028850B1 (ko) 2010-05-27 2011-05-26 히스톤 디아세틸라아제의 저해제들로서 유용한 거대고리 화합물들

Publications (1)

Publication Number Publication Date
KR20130123301A true KR20130123301A (ko) 2013-11-12

Family

ID=45004403

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020127033908A Abandoned KR20130123301A (ko) 2010-05-27 2011-05-26 히스톤 디아세틸라아제의 저해제들로서 유용한 거대고리 화합물들
KR1020187018653A Active KR102028850B1 (ko) 2010-05-27 2011-05-26 히스톤 디아세틸라아제의 저해제들로서 유용한 거대고리 화합물들

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020187018653A Active KR102028850B1 (ko) 2010-05-27 2011-05-26 히스톤 디아세틸라아제의 저해제들로서 유용한 거대고리 화합물들

Country Status (17)

Country Link
US (2) US8754050B2 (enExample)
EP (1) EP2575467B1 (enExample)
JP (1) JP5931850B2 (enExample)
KR (2) KR20130123301A (enExample)
CN (1) CN102946732B (enExample)
AU (1) AU2011258110B2 (enExample)
BR (1) BR112012030193B1 (enExample)
CA (1) CA2800958C (enExample)
DK (1) DK2575467T3 (enExample)
ES (1) ES2594500T3 (enExample)
HU (1) HUE030812T2 (enExample)
LT (1) LT2575467T (enExample)
MX (1) MX2012013507A (enExample)
PL (1) PL2575467T3 (enExample)
PT (1) PT2575467T (enExample)
RU (1) RU2565076C2 (enExample)
WO (1) WO2011150283A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170020377A (ko) * 2014-05-27 2017-02-22 온쿠레 인코포레이티드 사이클릭뎁시펩타이드의 제조 방법

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102391359B (zh) * 2011-11-17 2014-07-16 南京优科生物医药研究有限公司 组蛋白去乙酰化酶抑制剂及其合成方法和制药用途
CN103232474A (zh) * 2013-04-16 2013-08-07 中国药科大学 组蛋白去乙酰化酶抑制剂
CN106800589B (zh) * 2013-09-02 2021-01-12 李铁旦 一类环肽类化合物、其制备方法、药物组合物及用途
AU2016230008B2 (en) * 2015-03-06 2020-08-27 Colorado State University Research Foundation Synthesis and utility of new capgroup largazole analogs
AU2016229324B2 (en) 2015-03-06 2020-01-16 Colorado State University Research Foundation Method for preparing largazole analogs and uses thereof
CN105131082A (zh) * 2015-09-17 2015-12-09 广州康缔安生物科技有限公司 环肽类化合物及其应用
CN106674252B (zh) * 2015-11-11 2019-10-29 复旦大学 海洋天然产物环酯肽的氟代烯烃类似物、其制备方法和用途
CA3025045A1 (en) * 2016-05-20 2017-11-23 Onkure, Inc. Thioester prodrugs of macrocycles as inhibitors of histone deacetylases
CN107286223B (zh) * 2017-07-17 2019-12-20 湖北大学 一种用于检测组蛋白位点乙酰化的重组蛋白及其应用
CN111269245B (zh) * 2018-12-04 2021-08-27 杭州百新生物医药科技有限公司 一种环状氨基嘧啶衍生物及其抑制激酶的活性和用途
US20220017520A1 (en) * 2018-12-19 2022-01-20 Keythera (Suzhou) Pharmaceuticals Co. Ltd. Macrocyclic compound as cdk inhibitor, preparation method therefor, and use thereof in medicine
EP3941457A4 (en) * 2019-03-21 2023-04-26 Merck Sharp & Dohme LLC HISTONE-DEACETYLASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF HIV INFECTION
KR102436309B1 (ko) * 2020-05-26 2022-08-25 연세대학교 산학협력단 암의 예방 또는 치료용 약학적 조성물
US12227522B2 (en) 2020-12-21 2025-02-18 Colorado State University Research Foundation Synthesis of structural analogs of largazole and associated compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8920304D0 (en) 1989-09-08 1989-10-25 Fujisawa Pharmaceutical Co Fr901375 substance and preparation thereof
CA2497281A1 (en) * 2002-08-30 2004-03-11 Yamanouchi Pharmaceutical Co., Ltd. Novel depsipeptide compound
CN1711086A (zh) * 2002-11-12 2005-12-21 爱尔康公司 用于治疗眼的退化性疾病的组蛋白脱乙酰酶抑制剂
US20060128660A1 (en) * 2004-12-10 2006-06-15 Wisconsin Alumni Research Foundation FK228 analogs and methods of making and using the same
WO2008062201A1 (en) * 2006-11-22 2008-05-29 Karus Therapeutics Limited Depsipeptides and their therapeutic use
GB0623388D0 (en) * 2006-11-23 2007-01-03 Univ Southampton Chemical compounds
GB0715750D0 (en) * 2007-08-13 2007-09-19 Karus Therapeutics Ltd Chemical compounds
AU2009234398B2 (en) * 2008-04-11 2015-01-22 University Of Florida Research Foundation, Inc. Macrocyclic compounds and methods of treatment
WO2010009334A1 (en) * 2008-07-17 2010-01-21 Colorado State University Research Foundation Method for preparing largazole analogs and uses thereof
CN102391359B (zh) * 2011-11-17 2014-07-16 南京优科生物医药研究有限公司 组蛋白去乙酰化酶抑制剂及其合成方法和制药用途

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170020377A (ko) * 2014-05-27 2017-02-22 온쿠레 인코포레이티드 사이클릭뎁시펩타이드의 제조 방법
KR20220029761A (ko) * 2014-05-27 2022-03-08 온쿠레 인코포레이티드 사이클릭뎁시펩타이드의 제조 방법

Also Published As

Publication number Publication date
RU2565076C2 (ru) 2015-10-20
US20130203681A1 (en) 2013-08-08
CN102946732A (zh) 2013-02-27
BR112012030193B1 (pt) 2020-11-17
ES2594500T3 (es) 2016-12-20
PT2575467T (pt) 2016-10-14
AU2011258110A1 (en) 2013-01-10
AU2011258110B2 (en) 2015-07-16
BR112012030193A2 (pt) 2015-09-29
CA2800958C (en) 2018-09-04
EP2575467B1 (en) 2016-07-06
LT2575467T (lt) 2017-01-10
CN102946732B (zh) 2014-11-26
DK2575467T3 (en) 2016-09-26
EP2575467A1 (en) 2013-04-10
JP5931850B2 (ja) 2016-06-08
RU2012157293A (ru) 2014-07-10
EP2575467A4 (en) 2014-10-15
PL2575467T3 (pl) 2017-10-31
US20150010541A1 (en) 2015-01-08
HUE030812T2 (en) 2017-05-29
KR102028850B1 (ko) 2019-10-04
US9422340B2 (en) 2016-08-23
WO2011150283A1 (en) 2011-12-01
MX2012013507A (es) 2013-03-12
JP2013528182A (ja) 2013-07-08
CA2800958A1 (en) 2011-12-01
KR20180081153A (ko) 2018-07-13
US8754050B2 (en) 2014-06-17
HK1181613A1 (en) 2013-11-15

Similar Documents

Publication Publication Date Title
KR102028850B1 (ko) 히스톤 디아세틸라아제의 저해제들로서 유용한 거대고리 화합물들
JP4274946B2 (ja) ヒストン脱アセチル化酵素阻害剤およびその製造方法
JP2023139183A (ja) ヒストンデアセチラーゼの阻害剤としての大環状分子のチオエステルプロドラッグ
Class et al. Patent application title: Macrocyclic Compounds Useful as Inhibitors of Histone Deacetylases Inventors: Xuedong Liu (Niwot, CO, US) Andrew J. Phillips (Guilford, CT, US) Dana Ungermannova (Houston, TX, US) Christopher G. Nasveschuk (Stoneham, MA, US) Christopher G. Nasveschuk (Stoneham, MA, US) Gan Zhang (Niwot, CO, US) Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO
HK1181613B (en) Macrocyclic compounds useful as inhibitors of histone deacetylases
CN119816328A (zh) 多肽偶联物、包含所述多肽偶联物的药物组合物及其用途
HK40031377A (en) Thioester prodrugs of macrocycles as inhibitors of histone deacetylases

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20121226

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20160428

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20170501

Patent event code: PE09021S01D

E90F Notification of reason for final refusal
PE0902 Notice of grounds for rejection

Comment text: Final Notice of Reason for Refusal

Patent event date: 20171010

Patent event code: PE09021S02D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20180402

PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20180629

PC1904 Unpaid initial registration fee