KR20130110163A - 트리아졸로피라진 유도체들 - Google Patents
트리아졸로피라진 유도체들 Download PDFInfo
- Publication number
- KR20130110163A KR20130110163A KR20137007843A KR20137007843A KR20130110163A KR 20130110163 A KR20130110163 A KR 20130110163A KR 20137007843 A KR20137007843 A KR 20137007843A KR 20137007843 A KR20137007843 A KR 20137007843A KR 20130110163 A KR20130110163 A KR 20130110163A
- Authority
- KR
- South Korea
- Prior art keywords
- phenyl
- het
- triazolo
- substituted
- pyrazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- Chemical & Material Sciences (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10008927 | 2010-08-27 | ||
| EP10008927.5 | 2010-08-27 | ||
| PCT/EP2011/003830 WO2012025186A1 (en) | 2010-08-27 | 2011-07-29 | Triazolopyrazine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20130110163A true KR20130110163A (ko) | 2013-10-08 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| KR20137007843A Withdrawn KR20130110163A (ko) | 2010-08-27 | 2011-07-29 | 트리아졸로피라진 유도체들 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9023851B2 (https=) |
| EP (1) | EP2609098B1 (https=) |
| JP (1) | JP5951610B2 (https=) |
| KR (1) | KR20130110163A (https=) |
| CN (1) | CN103068828B (https=) |
| AR (1) | AR082726A1 (https=) |
| AU (1) | AU2011295440B2 (https=) |
| BR (1) | BR112013004517A2 (https=) |
| CA (1) | CA2809331C (https=) |
| EA (1) | EA201300282A1 (https=) |
| ES (1) | ES2614128T3 (https=) |
| IL (1) | IL224869A (https=) |
| MX (1) | MX2013002198A (https=) |
| SG (1) | SG188296A1 (https=) |
| WO (1) | WO2012025186A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2863723C (en) * | 2012-02-21 | 2020-09-22 | Carl Deutsch | 8-substituted 2-amino-[1,2,4]triazolo[1,5-a]pyrazines as syk tryrosine kinase inhibitors and gcn2 serin kinase inhibitors |
| WO2013131609A1 (en) * | 2012-03-07 | 2013-09-12 | Merck Patent Gmbh | Triazolopyrazine derivatives |
| CN104704129A (zh) | 2012-07-24 | 2015-06-10 | 药品循环公司 | 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变 |
| RU2015117950A (ru) * | 2012-10-26 | 2016-12-20 | Ф. Хоффманн-Ля Рош Аг | 3,4-дизамещенный 1н-пиразол и 4,5-дизамещенный тиазол в качестве ингибиторов тирозинкиназы syk |
| AU2014224975B2 (en) * | 2013-03-05 | 2017-09-14 | Merck Patent Gmbh | Triazolo(4,5-d)pyrimidine derivatives for the treatment of diseases such as cancer |
| AU2014224976B2 (en) * | 2013-03-05 | 2017-09-28 | Merck Patent Gmbh | 9-(aryl or heteroaryl)-2-(pyrazolyl, pyrrolidinyl or cyclopentyl)aminopurine derivatives as anticancer agents |
| CN105164136B (zh) * | 2013-05-06 | 2017-12-22 | 默克专利股份公司 | 作为激酶抑制剂的大环化合物 |
| US10821178B2 (en) | 2013-07-29 | 2020-11-03 | Board Of Regents Of The University Of Nebraska | Methods of treating biofilm infections comprising administering inhibitors of myeloid-derived suppressor cells |
| US9856263B2 (en) | 2014-04-28 | 2018-01-02 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine D1 ligands |
| KR101756934B1 (ko) | 2014-07-08 | 2017-07-12 | 연세대학교 산학협력단 | 피롤로[1,2-a]피라진 유도체, 이의 약학적으로 허용가능한 염, 이들 화합물의 제조방법 및 이를 유효성분으로 함유하는 골다공증 치료 또는 예방용 약학조성물 |
| SMT202100573T1 (it) | 2016-12-22 | 2021-11-12 | Calithera Biosciences Inc | Composizioni e metodi per l'inibizione dell'attivita' dell'arginasi |
| BR122023024273A2 (pt) | 2018-02-27 | 2024-02-20 | Incyte Corporation | Compostos imidazopirimidinas e triazolopirimidinas, seus usos, método para inibir uma atividade de um receptor de adenosina e composição farmacêutica dos mesmos |
| WO2019222677A1 (en) | 2018-05-18 | 2019-11-21 | Incyte Corporation | Fused pyrimidine derivatives as a2a / a2b inhibitors |
| GEP20237548B (en) | 2018-07-05 | 2023-10-10 | Incyte Corp | Fused pyrazine derivatives as a2a /a2b inhibitors |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| US20220143049A1 (en) | 2019-03-21 | 2022-05-12 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| TW202202498A (zh) * | 2020-07-01 | 2022-01-16 | 大陸商四川海思科製藥有限公司 | 一種並環雜環衍生物及其在醫藥上的應用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2596830A1 (en) * | 2005-02-03 | 2006-09-14 | Vertex Pharmaceuticals Incorporated | Pyrrolopyrimidines useful as inhibitors of protein kinase |
| JP4652906B2 (ja) * | 2005-06-30 | 2011-03-16 | 富士夫 宮脇 | 振動型マイクロインジェクション装置 |
| MX2008009557A (es) * | 2006-01-27 | 2009-01-07 | Shanghai Hengrui Pharm Co Ltd | Inhibidores de la cinasa de proteina de la pirrolo [3,2-c] piridin-4-ona-2-indolinona. |
| US7982033B2 (en) * | 2006-11-03 | 2011-07-19 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| WO2008118823A2 (en) | 2007-03-26 | 2008-10-02 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| GB0719803D0 (en) | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| SG2014015085A (en) | 2008-04-16 | 2014-06-27 | Portola Pharm Inc | 2,6-diamino-pyrimidin-5-yl-carboxamides as syk or jak kinases inhibitors |
| EP2288260A4 (en) | 2008-06-20 | 2013-10-23 | Genentech Inc | TRIAZOLOPYRIDINE-JAK HEMMER COMPOUNDS AND METHOD |
| BRPI0909945A2 (pt) | 2008-06-20 | 2015-07-28 | Genentech Inc | "composto, composição farmacêutica, método para tratar ou atenuar a gravidade de uma doença ou condição responsiva à inibição da atividade jak2 quinase em um paciente, kit para o tratamento de uma doença ou distúrbio responsivo à inibição da jak quinase" |
| WO2010010184A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | [1, 2, 4] triazolo [1, 5-a] pyridines as jak inhibitors |
| WO2010010188A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases. |
| WO2010010189A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases |
| TWI453207B (zh) * | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| CN102459258B (zh) * | 2009-06-05 | 2015-11-25 | 赛福伦公司 | 1,2,4-三唑并[1,5a]吡啶衍生物的制备和用途 |
| BR112012017310A2 (pt) * | 2010-01-15 | 2016-04-19 | Janssen Pharmaceuticals Inc | derivados de triazol substituídos como moduladores de gama secretase |
| US20110190269A1 (en) | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
-
2011
- 2011-07-29 WO PCT/EP2011/003830 patent/WO2012025186A1/en not_active Ceased
- 2011-07-29 JP JP2013526335A patent/JP5951610B2/ja not_active Expired - Fee Related
- 2011-07-29 BR BR112013004517A patent/BR112013004517A2/pt not_active Application Discontinuation
- 2011-07-29 EP EP11738630.0A patent/EP2609098B1/en not_active Not-in-force
- 2011-07-29 US US13/819,120 patent/US9023851B2/en active Active
- 2011-07-29 ES ES11738630.0T patent/ES2614128T3/es active Active
- 2011-07-29 AU AU2011295440A patent/AU2011295440B2/en not_active Ceased
- 2011-07-29 EA EA201300282A patent/EA201300282A1/ru unknown
- 2011-07-29 CA CA2809331A patent/CA2809331C/en not_active Expired - Fee Related
- 2011-07-29 KR KR20137007843A patent/KR20130110163A/ko not_active Withdrawn
- 2011-07-29 SG SG2013014006A patent/SG188296A1/en unknown
- 2011-07-29 MX MX2013002198A patent/MX2013002198A/es not_active Application Discontinuation
- 2011-07-29 CN CN201180041643.5A patent/CN103068828B/zh not_active Expired - Fee Related
- 2011-08-26 AR ARP110103111 patent/AR082726A1/es unknown
-
2013
- 2013-02-21 IL IL224869A patent/IL224869A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BR112013004517A2 (pt) | 2016-06-07 |
| AR082726A1 (es) | 2012-12-26 |
| JP2013538214A (ja) | 2013-10-10 |
| MX2013002198A (es) | 2013-03-18 |
| AU2011295440A1 (en) | 2013-04-11 |
| ES2614128T3 (es) | 2017-05-29 |
| US9023851B2 (en) | 2015-05-05 |
| IL224869A (en) | 2016-06-30 |
| JP5951610B2 (ja) | 2016-07-13 |
| SG188296A1 (en) | 2013-04-30 |
| EP2609098B1 (en) | 2016-07-13 |
| EP2609098A1 (en) | 2013-07-03 |
| EA201300282A1 (ru) | 2013-08-30 |
| CN103068828A (zh) | 2013-04-24 |
| CA2809331A1 (en) | 2012-03-01 |
| WO2012025186A1 (en) | 2012-03-01 |
| CA2809331C (en) | 2018-09-25 |
| US20130225568A1 (en) | 2013-08-29 |
| CN103068828B (zh) | 2015-09-09 |
| AU2011295440B2 (en) | 2015-06-11 |
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Patent event date: 20130327 Patent event code: PA01051R01D Comment text: International Patent Application |
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