KR20130099812A - 황반 부종을 치료하기 위한 약학적 조성물 - Google Patents
황반 부종을 치료하기 위한 약학적 조성물 Download PDFInfo
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- KR20130099812A KR20130099812A KR1020127029562A KR20127029562A KR20130099812A KR 20130099812 A KR20130099812 A KR 20130099812A KR 1020127029562 A KR1020127029562 A KR 1020127029562A KR 20127029562 A KR20127029562 A KR 20127029562A KR 20130099812 A KR20130099812 A KR 20130099812A
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- composition
- hydroxy
- alkyl
- fatty acid
- carbon atoms
- Prior art date
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- 125000000217 alkyl group Chemical group 0.000 claims description 55
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 41
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- 125000005907 alkyl ester group Chemical group 0.000 description 4
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 4
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- 159000000001 potassium salts Chemical class 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical class CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 125000003072 pyrazolidinyl group Chemical group 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000002098 pyridazinyl group Chemical group 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
- 125000005493 quinolyl group Chemical group 0.000 description 1
- 238000011555 rabbit model Methods 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 229910000077 silane Inorganic materials 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 235000019337 sorbitan trioleate Nutrition 0.000 description 1
- 229960000391 sorbitan trioleate Drugs 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000003206 sterilizing agent Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000002511 suppository base Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 150000005621 tetraalkylammonium salts Chemical class 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 239000012929 tonicity agent Substances 0.000 description 1
- 229940113006 travatan Drugs 0.000 description 1
- 229960002368 travoprost Drugs 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- RYYVLZVUVIJVGH-UHFFFAOYSA-N trimethylxanthine Natural products CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- TVHAZVBUYQMHBC-SNHXEXRGSA-N unoprostone Chemical compound CCCCCCCC(=O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O TVHAZVBUYQMHBC-SNHXEXRGSA-N 0.000 description 1
- 239000006216 vaginal suppository Substances 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 229920001567 vinyl ester resin Polymers 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 229940002639 xalatan Drugs 0.000 description 1
- 125000005023 xylyl group Chemical group 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32333810P | 2010-04-12 | 2010-04-12 | |
| US32334210P | 2010-04-12 | 2010-04-12 | |
| US61/323,338 | 2010-04-12 | ||
| US61/323,342 | 2010-04-12 | ||
| US32681110P | 2010-04-22 | 2010-04-22 | |
| US61/326,811 | 2010-04-22 | ||
| US36294510P | 2010-07-09 | 2010-07-09 | |
| US61/362,945 | 2010-07-09 | ||
| US40823710P | 2010-10-29 | 2010-10-29 | |
| US61/408,237 | 2010-10-29 | ||
| PCT/JP2011/059474 WO2011129457A1 (en) | 2010-04-12 | 2011-04-12 | Pharmaceutical composition for treating macular edema |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20130099812A true KR20130099812A (ko) | 2013-09-06 |
Family
ID=44798822
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020127029449A Withdrawn KR20130050939A (ko) | 2010-04-12 | 2011-04-12 | 망막 질환의 치료 방법 및 이를 위한 안과용 조성물 |
| KR1020127029562A Withdrawn KR20130099812A (ko) | 2010-04-12 | 2011-04-12 | 황반 부종을 치료하기 위한 약학적 조성물 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020127029449A Withdrawn KR20130050939A (ko) | 2010-04-12 | 2011-04-12 | 망막 질환의 치료 방법 및 이를 위한 안과용 조성물 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20110275715A1 (enExample) |
| EP (2) | EP2558103A4 (enExample) |
| JP (3) | JP5686819B2 (enExample) |
| KR (2) | KR20130050939A (enExample) |
| CN (2) | CN102933217A (enExample) |
| AR (1) | AR080888A1 (enExample) |
| CA (2) | CA2795720A1 (enExample) |
| TW (2) | TW201204366A (enExample) |
| WO (2) | WO2011129461A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120096555A (ko) | 2009-11-27 | 2012-08-30 | 가부시키가이샤 아루떼꾸 우에노 | 안구 건조증 및/또는 각결막 장해의 처치에 유용한 약제의 스크리닝 방법 및 그 방법에 의해 얻어진 의약 조성물 |
| JP2014510709A (ja) * | 2011-04-12 | 2014-05-01 | 株式会社アールテック・ウエノ | 眼科用水性組成物 |
| US20150037422A1 (en) * | 2012-02-22 | 2015-02-05 | Trustees Of Tufts College | Compositions and methods for ocular delivery of a therapeutic agent |
| WO2018036498A1 (en) * | 2016-08-24 | 2018-03-01 | National Institute Of Biological Sciences, Beijing | Entacapone-related compounds to treat macular degeneration |
| EP3946467A1 (en) * | 2019-04-03 | 2022-02-09 | REGENXBIO Inc. | Gene therapy for eye pathologies |
| WO2021087399A1 (en) * | 2019-10-30 | 2021-05-06 | Perfuse Therapeutics, Inc. | Treatment of ocular diseases using endothelin receptor antagonists |
| BR112022015579A2 (pt) | 2020-02-06 | 2022-10-11 | Perfuse Therapeutics Inc | Composições para tratamento de doenças oculares |
| JP2024515826A (ja) | 2021-04-30 | 2024-04-10 | パフューズ セラピューティクス， インコーポレイテッド | 眼疾患の処置のための薬学的組成物および硝子体内薬物送達システム |
| EP4366831A4 (en) | 2021-07-09 | 2025-06-11 | Aligos Therapeutics, Inc. | ANTI-VIRAL COMPOUNDS |
| US12065428B2 (en) | 2021-09-17 | 2024-08-20 | Aligos Therapeutics, Inc. | Anti-viral compounds |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6545036B2 (en) * | 2000-01-18 | 2003-04-08 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
| PE20020146A1 (es) * | 2000-07-13 | 2002-03-31 | Upjohn Co | Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2) |
| WO2003020283A2 (en) * | 2001-08-29 | 2003-03-13 | Novartis Ag | Method for treating diabetic retinopathy |
| KR20120005052A (ko) * | 2003-08-21 | 2012-01-13 | 수캄포 아게 | 안과용 조성물 |
| US20050119262A1 (en) * | 2003-08-21 | 2005-06-02 | Pharmacia Corporation | Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent |
| EP1848541A4 (en) * | 2005-02-07 | 2013-01-16 | Pharmalight Inc | METHOD AND DEVICE FOR THE OPHTHALMIC ADMINISTRATION OF PHARMACEUTICAL ACTIVE SUBSTANCES |
| US20100087540A1 (en) * | 2008-10-07 | 2010-04-08 | R-Tech Ueno, Ltd. | Pharmaceutical composition |
-
2011
- 2011-04-12 KR KR1020127029449A patent/KR20130050939A/ko not_active Withdrawn
- 2011-04-12 EP EP11768976.0A patent/EP2558103A4/en not_active Withdrawn
- 2011-04-12 AR ARP110101238A patent/AR080888A1/es unknown
- 2011-04-12 CA CA2795720A patent/CA2795720A1/en not_active Abandoned
- 2011-04-12 TW TW100112738A patent/TW201204366A/zh unknown
- 2011-04-12 CN CN201180028968XA patent/CN102933217A/zh active Pending
- 2011-04-12 CA CA2795723A patent/CA2795723A1/en not_active Abandoned
- 2011-04-12 EP EP11768978.6A patent/EP2558104A4/en not_active Withdrawn
- 2011-04-12 US US13/084,927 patent/US20110275715A1/en not_active Abandoned
- 2011-04-12 KR KR1020127029562A patent/KR20130099812A/ko not_active Withdrawn
- 2011-04-12 US US13/084,982 patent/US20110275711A1/en not_active Abandoned
- 2011-04-12 CN CN2011800290140A patent/CN102946883A/zh active Pending
- 2011-04-12 WO PCT/JP2011/059479 patent/WO2011129461A1/en not_active Ceased
- 2011-04-12 WO PCT/JP2011/059474 patent/WO2011129457A1/en not_active Ceased
- 2011-04-12 JP JP2012547193A patent/JP5686819B2/ja not_active Expired - Fee Related
- 2011-04-12 TW TW100112624A patent/TW201141486A/zh unknown
- 2011-04-12 JP JP2012544363A patent/JP5878128B2/ja active Active
-
2015
- 2015-09-30 JP JP2015194346A patent/JP2016026182A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN102946883A (zh) | 2013-02-27 |
| WO2011129457A1 (en) | 2011-10-20 |
| JP5686819B2 (ja) | 2015-03-18 |
| TW201204366A (en) | 2012-02-01 |
| EP2558103A1 (en) | 2013-02-20 |
| CA2795720A1 (en) | 2011-10-20 |
| EP2558103A4 (en) | 2013-09-25 |
| US20110275715A1 (en) | 2011-11-10 |
| US20110275711A1 (en) | 2011-11-10 |
| JP2013528563A (ja) | 2013-07-11 |
| JP2016026182A (ja) | 2016-02-12 |
| EP2558104A4 (en) | 2013-12-11 |
| EP2558104A1 (en) | 2013-02-20 |
| JP2013523601A (ja) | 2013-06-17 |
| CN102933217A (zh) | 2013-02-13 |
| WO2011129461A1 (en) | 2011-10-20 |
| JP5878128B2 (ja) | 2016-03-08 |
| KR20130050939A (ko) | 2013-05-16 |
| TW201141486A (en) | 2011-12-01 |
| AR080888A1 (es) | 2012-05-16 |
| CA2795723A1 (en) | 2011-10-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20121112 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |