KR20130089361A - Composition for use of reducing and controlling blood glucose for improving diabetes - Google Patents

Abstract

PURPOSE: A composition for reducing and controlling blood glucose is provided to prevent and cure an inflammation of the cells, which enhance glucose absorption in small intestine and glucose storage and consumption in liver and secret insulin, and surrounding cells, thereby preventing the apoptosis of insulin-secreting cells. CONSTITUTION: A composition or food for reducing and controlling blood glucose includes a free fatty acid reduction component, an anti-inflammatory drug, an antibiotic, an antioxidant, and a glucosidase inhibition component. The free fatty acid reduction component is lecithin. The anti-inflammatory drug is coixenolide or glycyrrhizin. The antibiotic is decanoyl acetaldehyde.

Description

Composition for use of reducing and controlling blood glucose for improving diabetes}

The present invention relates to a composition or food for lowering and controlling blood sugar. More specifically, the present invention enhances cell death of insulin secreting cells by enhancing sugar absorption in the small intestine, and storage and consumption of sugar in the liver, and preventing and treating inflammation of cells secreting insulin and / or its surrounding cells. A composition or foodstuff that prevents and lowers and controls blood sugar.

Diabetes is a type of metabolic disease, such as a lack of insulin secretion or normal function. Symptoms of diabetes are characterized by high blood sugar, which increases the concentration of glucose in the blood, and these high blood sugar is known to release glucose from the urine and cause various complications.

This type of diabetes is divided into type 1 and type 2, type 1 diabetes is also called 'child diabetes', which is a disease caused by not producing any insulin.

Unlike type 1 diabetes, type 2 diabetes refers to a disease caused by a relatively low amount of insulin production ability. Type 2 diabetes is characterized by a lack of insulin resistance, ie insulin function that lowers blood sugar, so that cells do not burn glucose effectively.

It has been known that environmental factors such as high calorie, high fat, high protein diet, lack of exercise, and stress due to westernization of diet have a significant effect on the onset of type 2 diabetes. It is actively underway.

Republic of Korea Patent No. 10-1027413, the existing diabetic improved food pointed out that the texture is a problem, and the low glycemic index (GI) by mixing a low-glycemic (GI) germ brown rice, calico barley, while having a glycemic control effect This good mixed grain composition is disclosed.

In another prior art, the Republic of Korea Patent No. 10-1083358, containing the mushroom extract extracts inhibiting the rapid rise of blood glucose after meals by inhibiting the activity of glucosidase and α-amylase that antagonizes insulin Disclosed are yogurt and tofu.

As described above, the prior art related to the composition for improving type 2 diabetes is known, which lowers the glycemic index of the composition to reduce the rise in blood sugar, or inhibits the action of enzymes such as glucosidase to suppress rapid blood sugar rise. Most of them work. However, these prior arts are only passive methods of lowering the level of newly ingested and absorbed sugar in the body, and do not address the problem of insulin deficiency or insulin function that causes diabetes.

Therefore, there is an urgent need for a composition that directly participates in insulin secreting cells and / or mechanisms thereof, after ingestion of food, rather than indirectly lowering its sugar levels, thereby preventing and improving insulin secretion and function.

Republic of Korea Patent Publication B1 No. 10-1027413 (August 11, 2011) Republic of Korea Patent Publication B1 No. 10-1083358 (August 15, 2011)

In order to solve the above-mentioned problems, the present inventors have focused on the fact that the inflammation of the cells secreting insulin and thus cell death may increase blood sugar and contribute to the development and development of symptoms of type 2 diabetes. By preventing and treating inflammation, the inventors have invented a composition that lowers and appropriately regulates blood sugar.

Specifically, an object of the present invention is to provide a composition or food for lowering and controlling blood glucose, which contains a naturally occurring free fatty acid (FFA) reducing component, an anti-inflammatory agent, an antibiotic, an antioxidant, and a glucosidase inhibitory component. do.

One aspect of the present invention provides a composition or food for lowering and controlling blood glucose, which contains a free fatty acid (FFA) reducing component, an anti-inflammatory agent, an antibiotic, an antioxidant, and a glucosidase inhibitory component.

According to another aspect of the present invention, the free fatty acid reducing component is lecithin (Lecithin), provides a composition or food for lowering and controlling blood sugar.

According to another aspect of the present invention, the anti-inflammatory agent is Coixenolide (Gixenolide) or glycyrrhizin (Glycyrrhizin), provides a composition or food for lowering and controlling blood sugar.

According to another aspect of the present invention, the antibiotic agent is decanoiacetaldehyde (Decanoilacetaldehyde), provides a composition or food for lowering and controlling blood sugar.

According to another aspect of the present invention, the antioxidant provides a composition or food for lowering and controlling blood sugar, which is at least one selected from the group consisting of catechin, polyphenol, and quercitrin. .

According to another aspect of the present invention, the glucosidase inhibitory component is 1-deoxynojirimycin, which provides a composition or food for reducing blood sugar and regulating it.

According to another aspect of the present invention, the free fatty acid reduction component, anti-inflammatory agent, antibiotics, antioxidants and glucosidase inhibitory components are derived from natural materials, provides a composition or food for lowering and controlling blood sugar.

According to another aspect of the present invention,

a) said free fatty acid reducing component is lecithin derived from soybean;

b) said anti-inflammatory agent is coicenolide derived from yulmu or glycyrrhizin derived from licorice;

c) the antibiotic is decanoyl acetaldehyde derived from fish herb;

d) the antioxidant is at least one member selected from the group consisting of catechins derived from green tea, polyphenols derived from mulberry leaves, and quercitrin derived from fish herb;

e) The glucosidase inhibitory component is 1-deoxy nozirimycin derived from mulberry leaves;

Provided is a composition or food for reducing blood sugar and regulating it.

According to another aspect of the present invention, the composition further comprises a non-digestable dietary fiber (Undigestable dietary fiber), provides a composition or food for blood sugar lowering and control.

According to another aspect of the present invention, the non-digestible dietary fiber is Inulin, which provides a composition or food for lowering and controlling blood sugar.

According to another aspect of the present invention, the inulin is derived from pork potato (Jerusalem artichoke), provides a composition or food for lowering and controlling blood sugar.

According to another aspect of the present invention, there is provided a composition or food for reducing blood sugar and regulating it, containing soybeans, yulmu, green tea, eochocho, mulberry leaves, pork potatoes and licorice.

According to another embodiment of the present invention, with respect to 100 parts by weight of beans, 15 to 60 parts by weight of green tea, 0.1 to 15 parts by weight of green tea, 0.1 to 20 parts by weight of green tea, 1 to 25 parts by weight of mulberry leaves, 1 to 25 of pork potatoes Provided are compositions or foods for lowering and controlling blood sugar, containing 1 part by weight and 1 to 25 parts by weight of licorice.

According to another aspect of the present invention, there is provided a meal replacement composition for lowering blood sugar and adjusting the composition or food.

The composition or food for lowering and regulating blood glucose of the present invention enhances insulin secretion by enhancing the absorption of sugar in the small intestine, the storage and consumption of sugar in the liver, and preventing and treating inflammation of cells secreting insulin and / or its surrounding cells. It shows the effect of preventing cell death of cells.

In addition, the present invention exhibits the effect of lowering and controlling blood glucose, further preventing and improving diabetes.

In addition, according to one aspect of the present invention, there is an advantage that is made of a component derived from a natural material without the addition of artificial chemicals, does not cause excessive irritation to the human body when ingested.

In addition, according to one aspect of the present invention, by containing a variety of nutrients and components that have a blood sugar lowering and regulating efficacy, as well as further comprising dietary fiber that eliminates fasting to this benefit that can be utilized as a meal replacement for weight control have.

In addition, according to one aspect of the present invention, by providing a meal replacement composition that is mixed by milling the components having a blood sugar lowering and regulating efficacy as it is, there is an advantage to manage the blood sugar while easily ingested in daily life.

Hereinafter, the present invention will be described in more detail. Those skilled in the art will appreciate that various modifications, additions and substitutions are possible, without departing from the scope and spirit of the invention as disclosed in the accompanying claims.

The present invention prevents cell death of insulin secreting cells and lowers blood sugar by enhancing the uptake of sugars in the small intestine and the storage and consumption of sugars in the liver and preventing and treating inflammation of insulin secreting cells and / or their surrounding cells. And to compositions or foods that are controlled and controlled.

More specifically, the present invention relates to compositions or foods that prevent and treat inflammation of β-cells and / or surrounding cells involved in insulin secretion.

β-cells, together with α-cells and δ-cells, form the islet cells and are responsible for insulin secretion. Inflammation of these β-cells leads to apoptosis, which causes insulin secretion mechanisms not to work normally, leading to diabetes or worsening.

The inventors of the present invention focus on restoring and strengthening not only the pancreas but also the functions of the liver and small intestine involved in the blood glucose absorption, storage and consumption mechanisms in order to prevent cell death of the above-described insulin secreting cells.

A composition for lowering and controlling blood glucose has been developed that contains a free fatty acid (FFA) reducing component, an anti-inflammatory agent, an antibiotic, an antioxidant, and a glucosidase inhibitory component.

Free Fatty Acid (FFA) refers to lipids that are broken down by triglycerides accumulated in adipocytes and are included in fatty acids in the blood.

Increasing these free fatty acids increases the intracellular content of fatty acid metabolites such as diacylglycerol (DAG), fatty acid acyl-CoA, ceramide, and the like. Serine / Threonine phosphorylation is induced on the receptor substrates IRS-1 and IRS-2 to interfere with the signaling system between insulin and receptor. This disruption of signal transduction between insulin-receptors results in lower insulin sensitivity in the body, leading to insulin resistance.

When the insulin resistance is intensified, the function of insulin in the body is lowered, thereby excessively stimulating β-cells to promote insulin secretion, which results in hyperinsulinmia, which further intensifies insulin resistance. It is expected to be. As a result, β-cells are repeatedly stimulated to induce inflammation and, in more severe cases, to apoptosis, ultimately leading to a decrease in insulin production or discontinuation of secretion.

The present invention provides a composition or food for reducing blood sugar and regulating a blood sugar containing a free fatty acid reducing component in order to lower the body content of free fatty acids, which is one of the substances causing such a mechanism.

The free fatty acid reducing component used in the present invention means having a function of inhibiting or reducing the production of free fatty acids in the body.

The free fatty acid reduction component used in the present invention may preferably be a component derived from a natural material, more preferably lecithin.

The lecithin may be preferably derived from soybeans.

Soy beans that can be used in the present invention is a one-year-old plant belonging to the dicotyledonous rosemary legume family, rich in protein, lecithin and dietary fiber, and has been used in various ways in our diet since ancient times.

Soybeans contain a lot of blood-cleaning ingredients, such as lecithin, saponin, and isoflavones. Specifically, lecithin prevents LDL cholesterol from accumulating in blood vessels and inhibits or reduces the production of free fatty acids in the body. Saponins act to prevent the oxidation of unsaturated fatty acids. Isoflavones work similar to the female hormone estrogen to prevent the deposition of unnecessary triglycerides in the blood vessels.

In addition, soy contains about 42% by weight of protein, which is a source that can provide high protein in place of meat, but also contains soluble dietary fiber that is soluble in blood that is not contained in meat foods, as well as carbohydrates and fats. It contains all of the minerals, minerals, and vitamins, making it an excellent food product with six even distributions of nutritional physiology.

The protein in soy is a vegetable protein that reduces fasting, improves satiety, and is low in calories compared to protein.

The fat content of soybeans includes the three essential fatty acids, linoleic acid, linoleic acid and arachidonic acid, which form the basis for prostaglandin.

The prostaglandins are a kind of topical hormone, a physiologically active substance, which expands blood vessels, decreases arterial pressure, inhibits excessive cholesterol synthesis, inhibits inflammation, activates T-lymphocytes, inhibits proliferation of abnormal cells, inhibits platelet aggregation, and promotes metabolism of body fat. It is an important substance that regulates various actions in the body, such as suppressing excessive secretion of gastric juice, inhibiting hardening of organ muscles, or preventing aging.

Vitamins contained in soybeans include vitamin B group, vitamin E, vitamin A, and vitamin K. Minerals contained in soybeans include calcium, phosphoric acid, and manganese.

In addition, the beans contain antioxidants that remove free radicals, improve blood circulation and lower cholesterol levels.

The soybean used in the present invention may be contained preferably 40 to 80 parts by weight, and more preferably 50 to 70 parts by weight, based on 100 parts by weight of the blood sugar lowering and controlling composition. Within the above content range, a sufficient free fatty acid reduction effect can be obtained, and further, there is an advantage of obtaining excellent physiological activity.

The present invention provides a composition or food for lowering and regulating blood glucose containing an anti-inflammatory agent for preventing and treating inflammation of insulin secreting cells and / or surrounding cells thereof.

Anti-inflammatory agents used in the present invention means to function to inhibit or eliminate inflammation.

The anti-inflammatory agents used in the present invention may preferably be components derived from natural materials.

The anti-inflammatory agent used in the present invention may be more preferably Coixenolide or Glycyrrhizin.

The coixenolide may be preferably derived from yulmu.

Coix lachryma - jobi there is . mayuen ) is an annual plant belonging to the monocotyledonous rice plant, which has a high protein content and reduces fasting, and has been used as a sulfur crop since ancient times.

Yulmu is made up of starch, protein and fat.

Coixenolide contained in Yulmu is known as an anti-tumor substance and is known to be excellent in anti-inflammatory action. In addition, it is known to be involved in lowering blood pressure and lowering blood sugar.

The yulmu used in the present invention may be contained preferably 5 to 45 parts by weight, more preferably 10 to 30 parts by weight with respect to 100 parts by weight of the blood sugar lowering and control composition. A sufficient anti-inflammatory effect can be obtained within the above content range, and further, blood pressure lowering and blood sugar lowering effects can be obtained.

The glycyrrhizin may be preferably derived from licorice.

Licorice ( Glycyrrhiza uralensis ) is a perennial plant belonging to the dicotyledon rose rosaceae, which is known to remove inflammation and detoxify the body.

More specifically, licorice acts to relieve inflammation by components such as glycyrrhizin, and lowers the acidity in the stomach to suppress the secretion of gastric juice, thereby suppressing the formation of ulcers such as gastric ulcer or duodenal ulcer. Therefore, it is effectively used for the treatment of digestive diseases.

In addition, glycyrrhizine contained in licorice is effective in the treatment of hepatitis because it inhibits the progression of cirrhosis and prevents liver tissue damage, thereby protecting the liver function, and is effective in the treatment and storage of blood sugar in the liver. It has the effect of strengthening and restoring function.

In addition, licorice has a cholesterol-lowering effect, thereby preventing atherosclerosis.

Meanwhile, flavonoid oil contained in licorice is known to contain a large amount of antioxidants, which not only promotes body fat removal but also significantly helps in weight control.

The licorice used in the present invention may be contained preferably 0.1 to 20 parts by weight, more preferably 1 to 10 parts by weight based on 100 parts by weight of the blood sugar lowering and control composition. A sufficient anti-inflammatory effect can be obtained within the above content range, and cholesterol lowering and / or body fat removing effect can be obtained.

Antibiotics (Anti-biotics) used in the present invention means to function to inhibit or inhibit the development and life functions of bacteria or other microorganisms.

The antibiotic used in the present invention may preferably be a component derived from a natural material, more preferably, decanoiacetaldehyde.

The decanoyl acetaldehyde may be preferably derived from fish herb.

Eochocho ( Houttuynia cordata ) is a perennial plant of more than three hundred years old dicotyledonous plant, which is known to have excellent detoxification and anti-inflammatory effects.

Eoseongcho also works to clear the blood. More specifically, isoquercitrin and quercitrin contained in eoseongcho to expand the capillaries to promote the blood transport of capillaries, blood circulation and the resulting metabolism is active to clear the blood It has the effect of getting rid of toxins.

The fish herb used in the present invention may be contained in an amount of preferably 0.1 to 15 parts by weight, more preferably 0.5 to 10 parts by weight with respect to 100 parts by weight of the blood sugar lowering and controlling composition. A sufficient antimicrobial effect can be obtained within the above content range, and blood circulation and thus metabolism can be smoothed.

Antioxidant (Antioxidant) used in the present invention means inhibiting the aging or functional impairment of cells, tissues, organs, etc. by the action of free radicals.

Antioxidants used in the present invention may preferably be components derived from natural materials.

The antioxidant used in the present invention may be more preferably selected from the group consisting of catechin (Cathechin), polyphenol (Polyphenol) and quercitrin (Quercitrin). These can be used individually or in mixture of 2 or more.

The catechins usable in the present invention may be preferably derived from green tea.

Green tea is a nearly zero calorie food containing catechin, caffeine, vitamin C, free amino acids, and polyphenols.

Green tea has the effect of decomposing glycogen accumulated in the body due to excessive intake of food, promoting metabolism, reducing weight, inhibiting fat accumulation, and promoting burning of fat as an energy source when ingested. Therefore, the utilization as a food for weight control is excellent.

Catechin contained in green tea is excellent in antioxidant function and anti-aging function, and acts to suppress rapid blood sugar rise by delaying digestion and absorption of sugar. In addition, the action of inhibiting the accumulation of cholesterol, neutral lipids, and the like, and has the effect of preventing cardiovascular diseases associated with diabetes.

The green tea used in the present invention may be contained in an amount of more than 0 to 10 parts by weight, and more preferably 0.01 to 5 parts by weight, based on 100 parts by weight of the blood sugar lowering and controlling composition. A sufficient antioxidant effect can be obtained within the above content range, and a delay in digestion and / or body fat accumulation can be obtained.

The polyphenols usable in the present invention may preferably be derived from mulberry leaves.

Mulberry leaves contain abundant antioxidants of polyphenols and are excellent in antioxidant activity.As described later, a mulberry leaf inhibitor contains a glycolytic enzyme inhibitor called deoxynojirimycin, which leads to rapid blood sugar elevation after meals. It has the effect of suppressing.

In addition, mulberry leaves contain cholesterol-lowering ingredients, and contains a lot of dietary fiber to activate the bowel function and slow down the rate of digestion of sugar in the stomach and intestines.

Mulberry leaves are high-protein foods that contain more protein than soybeans after plants, and are rich in more than 50 minerals, including calcium and iron.

The mulberry leaf used in the present invention may be preferably contained in 0.1 to 20 parts by weight, more preferably 1 to 15 parts by weight with respect to 100 parts by weight of the blood sugar lowering and control composition. A sufficient antioxidant effect can be obtained within the content range, and an effect of suppressing a sharp rise in blood sugar after eating can be obtained.

Quercitrin usable in the present invention may preferably be derived from fish herb.

The quercitrin is effective in lowering cholesterol levels, clearing blood, and expanding capillaries, thereby preventing and improving cardiovascular diseases.

Glucosydase inhibitory component used in the present invention means a component that inhibits and interferes with the enzymatic activity of glucosidase.

The glucosidase inhibitory component used in the present invention may preferably be a component derived from natural materials, and more preferably 1-deoxynojirimycin.

The 1-deoxy nojirimycin used in the present invention may be preferably derived from mulberry leaves.

The 1-deoxy nozirimycin exhibits the effect of inhibiting the activity of glucosidase and thus inhibiting and delaying the absorption of sugar occurring in the small intestine.

According to still another aspect of the present invention, there is provided a composition or food for lowering and controlling blood glucose, further comprising non-digestible dietary fiber in the composition.

The non-digestible dietary fiber usable in the present invention may preferably be derived from natural materials, more preferably Inulin.

The inulin usable in the present invention is preferably pork potato (Jerusalem artichoke, scientific name: Helianthus tuberosus ).

Pork potato is a perennial plant belonging to the dicotyledonous asteraceae, which contains a large amount of inulin, a kind of storage polysaccharide, in colloidal form.

Inulin in the pork potato is hydrolyzed by an enzyme called inulinase. However, because inulinase is not secreted in the human body, inulin is relatively well soluble in water, but inulin is not hydrolyzed in the body, so it is not absorbed into the body and is mostly discharged out of the body.

Therefore, the pork potato containing a large amount of inulin has high utilization as a food for weight control as a dietary fiber that completely eliminates fasting while having very low calories.

The pork potato that can be used in the present invention may be contained preferably 0.1 to 20 parts by weight, more preferably 1 to 10 parts by weight with respect to 100 parts by weight of the blood sugar lowering and control composition. The non-digestible dietary fiber is sufficiently provided within the above content range to obtain a weight control effect due to the intake of low calorie foods.

According to another aspect of the present invention, there is provided a composition or food for reducing blood sugar and regulating, containing soybeans, yulmu, green tea, eochocho, mulberry leaves, pork potatoes and licorice.

In the composition or food, based on 100 parts by weight of the soybeans, the yulmu may preferably be 15 to 60 parts by weight, more preferably 25 to 50 parts by weight.

In the composition or food, based on 100 parts by weight of the soybeans, the green tea may be preferably 0.1 to 15 parts by weight, more preferably 0.5 to 10 parts by weight.

In the composition or food, based on 100 parts by weight of the soybeans, the fish paste may be 0.1 to 20 parts by weight, more preferably 1 to 15 parts by weight.

In the composition or food, based on 100 parts by weight of the beans, the mulberry leaf may be preferably 1 to 25 parts by weight, more preferably 1 to 15 parts by weight.

In the composition or food, based on 100 parts by weight of the soybeans, the pork potato may preferably be 1 to 25 parts by weight, more preferably 1 to 15 parts by weight.

In the composition or food, based on 100 parts by weight of the soybeans, the licorice may be 1 to 25 parts by weight, more preferably 1 to 15 parts by weight.

The blood sugar lowering and control composition or the formulation of food of the present invention is not particularly limited and may be prepared in an ingestible form commonly used in the art.

Non-limiting examples of the blood sugar lowering and regulating composition or food formulation of the present invention, powder or granule form, liquid form, solid form and the like.

The blood sugar lowering and control composition or food of the present invention may be prepared more preferably in powder form.

The blood sugar lowering and regulating composition of the present invention may be more preferably used as a meal substitute, and the term "meal substitute" refers to a food prepared and processed to substitute food by appropriately subtracting nutrients necessary for the human body. it means.

Non-limiting examples of meal replacement composition formulations include powder, liquid, paste, flake or solid form, and more preferably in powder form.

Hereinafter, the present invention will be described in more detail by describing Examples. However, the following embodiments are only examples of the present invention and should not be construed as limiting the scope of the present invention. Furthermore, various modifications and variations can be made to embodiments of the present invention by those skilled in the art.

Example  One

Preparation of Meal Replacement Powder Containing Composition for Lowering and Adjusting Blood Sugar

1) Commercial soybeans and yulmu were obtained, roasted and milled, and the weight composition ratio of the beans: yulmu was mixed at 5: 2 to prepare a first sample.

2) Commercially available green tea, eosungcho and mulberry leaves were obtained and milled, and a second sample was prepared by mixing the weight composition ratio of green tea: eoseongcho: mulberry leaves in a 1: 3: 6 mixture.

3) Commercially available pork potatoes and licorice were obtained and milled, and the weight composition ratio of pork potato: licorice was mixed at 1: 1 to prepare a third sample.

The first sample: the second sample: the third sample was mixed so that the weight composition ratio is 10: 1: 1 to prepare a meal replacement powder for blood sugar lowering and control.

Example  2

Blood Glucose Determination after Ingestion of Hypoglycemic and Control Meal Replacements

In order to measure the effect of suppressing the rapid blood sugar rise of the meal substitute prepared in Example 1, the following clinical trials were conducted.

Thirty diabetic outpatient patients at Asan Medical Center were divided into two groups. In the first group (25 patients), 30 g of the meal replacement powder prepared in Example 1 was placed in 400 ml of water and stirred to dissolve well. In the second group (5 persons), 30 g of ordinary wheat flour (ingredients: brown rice, barley, non-glutinous rice, jade powder, white peach, chestnut, carrot, glutinous rice, black sesame, wheat and tea); 400 ml of water was added and stirred to dissolve well.

Each patient twice daily (for breakfast and at 4 pm), the meal replacement Or they took 6 weeks of flour, and lunch and dinner were not particularly limited.

After 6 weeks, fasting blood sugar and postprandial blood sugar of 25 patients taking the meal replacement meal and 5 patients taking wheat flour were measured, and the average value was calculated, and the change in the blood glucose level was compared with the respective average value before taking the meal. It was.

The measurement results are shown in Table 1 below.

Fasting Blood Sugar (mg / dL) Postprandial Blood Sugar (mg / dL) Before taking After 6 weeks Blood sugar change Before taking After 6 weeks Blood sugar change Example 1 177.63 152.25 25.38 reduction 264.67 204.92 59.75 reduction mixed grain powder 150.25 166.5 16.25 increase 238.5 237.5 1 decrease

As shown in Table 1, when the hypoglycemic and control meal replacement formulas according to Example 1 were taken for 6 weeks, fasting blood glucose was reduced by 25.38 mg / dL than before, and blood glucose after meals was 59.75 mg than before. / dL was found to be significantly reduced.

On the other hand, when taking normal wheat flour on the market, fasting blood sugar increased by 16.25 mg / dL rather than before, and in the case of postprandial blood sugar, 1 mg / dL decreased compared to before taking it, confirming that almost no improvement in hyperglycemia was achieved. Could.

Example  3

After taking a hypoglycemic and control meal replacement Glycated blood  Pigment measurement

In order to measure the glycated hemoglobin (HbA1c) level change after ingestion of the meal substitute prepared in Example 1, a clinical trial was conducted by the same method as in Example 2.

The measurement results for the glycated hemoglobin level measured before and 6 weeks after taking the meal replacement meal or wheat flour are shown in Table 2 below.

Glycated hemoglobin level (%) Before taking After 6 weeks Changes in glycated hemoglobin level Example 1 9.15 8.7 0.45 reduction mixed grain powder 7.4 7.4 0

As shown in Table 2, when taking the blood sugar lowering and control meal replacement formula according to Example 1 for 6 weeks, the reduction rate of 5% compared to the glycated hemoglobin level before taking. On the other hand, intake of wheat flour did not show any difference from the glycated hemoglobin level before taking.

Claims (14)

A composition or food for lowering and regulating blood glucose, comprising a free fatty acid (FFA) reducing component, an anti-inflammatory agent, an antibiotic, an antioxidant, and a glucosidase inhibitory component. According to claim 1, wherein the free fatty acid reducing component is lecithin (Lecithin), blood sugar lowering and control composition or food. According to claim 1, wherein the anti-inflammatory agent Coixenolide (Coixenolide) or glycyrrhizin (Glycyrrhizin), the composition or food for blood sugar lowering and control. According to claim 1, wherein the antibiotic is decanoyl acetaldehyde (Decanoilacetaldehyde), blood sugar lowering and control composition or food. According to claim 1, wherein the antioxidant is catechin (Cathechin), polyphenol (Polyphenol) and quercitrin (Quercitrin) is one or more selected from the group consisting of, blood sugar lowering and control composition or food. According to claim 1, wherein the glucosidase inhibitory component is 1-deoxynojirimycin (1-Deoxynojirimycin), blood sugar lowering and control composition or food. The composition or food for lowering and regulating blood glucose according to any one of claims 1 to 6, wherein the free fatty acid reducing component, anti-inflammatory agent, antibiotic, antioxidant and glucosidase inhibitory component is derived from natural materials. 7. The method according to any one of claims 1 to 6,
a) said free fatty acid reducing component is lecithin derived from soybean;
b) said anti-inflammatory agent is coicenolide derived from yulmu or glycyrrhizin derived from licorice;
c) the antibiotic is decanoyl acetaldehyde derived from fish herb;
d) the antioxidant is at least one selected from the group consisting of catechins derived from green tea, polyphenols derived from mulberry leaves, and quercitrin derived from fish herb;
e) The glucosidase inhibitory component is 1-deoxy nozirimycin derived from mulberry leaves;
Characterized in that, blood sugar lowering and regulating composition or food. The composition or food for lowering and regulating blood sugar according to any one of claims 1 to 6, further comprising Undigestable dietary fiber. The composition or food for lowering and regulating blood glucose of claim 9, wherein the non-digestible dietary fiber is Inulin. The composition or food for lowering and regulating blood glucose of claim 10, wherein the inulin is derived from pork potato (Jerusalem artichoke). A composition or food for reducing blood sugar and regulating it, containing soybeans, yulmu, green tea, eochocho, mulberry leaves, pork potatoes and licorice. According to claim 12, To 100 parts by weight of the beans, 15 to 60 parts by weight, green tea 0.1 to 15 parts by weight, 0.1 to 20 parts by weight of eoseongcho, 1 to 25 parts by weight of mulberry leaves, 1 to 25 parts by weight of pork potatoes and 1 to 25 parts by weight of licorice, blood sugar lowering and control composition or food. A meal substitute composition for lowering blood sugar and regulating it, comprising the composition or food according to claim 1.