JP4316234B2 - Diet food - Google Patents
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Description
【０００１】
【発明の属する技術分野】
本発明は、ダイエット用の食品組成物に関する。
【０００２】
【従来の技術】
近年栄養状態の変化、食生活の変化、運動の慢性的不足などの種々の社会的要因が重なって、肥満或いは過剰のカロリー摂取が大きな社会的問題となってきている。この様なカロリーの過剰摂取、それによって起こる肥満は、糖尿病、高脂血症、シンドロームＸ等の原因となって、これらの成人病へ発展していくことが懸念されており、保健行政の観点からも重大な課題となっている。この様な社会情勢を背景として、肥満を予防する為の種々の方策が考え出されている。例えば、グルコマンナンなどの非消化性のゲル組成物を食前に投与し、物理的に食事量を制限する方法、１−デオキシノジリマイシン等のα−グルコシダーゼ阻害剤を投与して、糖質の消化を抑制して、カロリーの過剰摂取を抑制する方法やキトサンやギムネマ・シルベスタの抽出物などを利用して糖質の吸収を阻害し、カロリーの過剰摂取を抑制する方法などが知られている(特開平６−１８１７０２、特開２０００−２８１５８３、特開２００１−１０３９２８)。しかしながら、これらにおいて決定的なものが登場していない理由としては、ダイエットの継続性が困難であることが挙げられる。即ち、何れの素材においても、カロリーの過剰摂取効果は認められるにもかかわらず、実効が現れるまで継続的に摂取できないことが、効を奏さない理由といえる。言い換えれば、ダイエット用の食品において、その摂取継続性を維持する手段の開発が望まれていた。
【０００３】
一方、カルシウムについては、既にストレスを緩和する作用を有することが知られており(特開平７−３０８１４７、特開２０００−７５７３、特開２００２−１１９２５０)、かかるカルシウムの内、乳清中に存在する、乳清カルシウムが特に吸収、生体利用性に優れることは知られている(特開２００１−９５４８８)。しかしながら、その摂取の継続性を改善する目的で、ダイエット用の食品に含有させることは全く知られていない。従って、１）α−グルコシダーゼ阻害剤と２）ストレス緩和剤とを含有する食品組成物が、その摂取継続性と、カロリーの過剰摂取抑制に優れることは全く知られていない。
【０００４】
【発明が解決しようとする課題】
本発明は、この様な状況下為されたものであり、α−グルコシダーゼ阻害剤を含有するダイエット用の食品組成物に於いて、その摂取の継続性を改善する技術を提供することを課題とする。
【０００５】
【課題の解決手段】
本発明者らは、この様な状況に鑑みて、α−グルコシダーゼ阻害剤を含有するダイエット用の食品組成物に於いて、その摂取の継続性を改善する手段を求めて、鋭意研究努力を重ねた結果、ダイエット用の食品組成物の摂取の継続を阻害しているのが、ダイエットを実行しているという認識のストレスであり、該ストレスを緩和することにより継続性が維持できることを見出した。即ち、１）α−グルコシダーゼ阻害剤と２）ストレス緩和剤とを含有する食品組成物が、ダイエット用の食品として好適な性質を有していることを見出し、発明を完成させるに至った。即ち、本発明は、以下に示す技術に関するものである。（１）１）α−グルコシダーゼ阻害剤として桑の葉及び桑の葉からのアルコール及び／又は水による抽出エキスと２）ストレス緩和剤としてカルシウムとを含有することを特徴とする、ダイエット用の食品組成物であって、桑の葉の乾燥物を食品組成物全量に対して１５〜２０質量％、及び桑の葉からのアルコール及び／又は水による抽出エキスを食品組成物全量に対して２０〜３０質量％含有することを特徴とする、食品組成物。
（２）カルシウムが、乳清カルシウムであることを特徴とする、（１）に記載のダイエット用の食品組成物。
（３）更に、非消化性素材としてキトサンを含有することを特徴とする、（１）又は（２）に記載のダイエット用の食品組成物。
（４）更に、非消化性素材としてマルチトール及び／又は結晶セルロースを含有することを特徴とする、（１）〜（３）の何れかに記載のダイエット用の食品組成物。
【０００６】
【発明の実施の形態】
（１）本発明の食品組成物の必須成分であるα−グルコシダーゼ阻害剤
本発明の食品組成物は、α−グルコシダーゼ阻害剤として桑の葉及び桑の葉エキスを含有することを特徴とする。α−グルコシダーゼ阻害剤は食物中の糖質がブドウ糖に分解される過程を阻害することにより、血糖値の急激な上昇を抑制する。その結果、血糖値の上昇がゆるやかになることでインスリンの分泌量も減少し、脂肪細胞での脂肪の合成量が減少し肥満を予防あるいは改善できる。α−グルコシダーゼ阻害物質としては、例えば１−デオキシノジリマイシンが挙げられ、１−デオキシノジリマイシンは桑葉等に含まれている。即ち、桑の葉及び桑の葉エキスを本発明のα−グルコシダーゼ阻害剤として用いる。ここでエキスとは、植物体の一部又は全部を溶剤で抽出した抽出物、該抽出物から溶剤を除去した溶媒除去物、抽出物乃至は溶媒除去物を分画精製した分画物の総称を意味する。抽出物としては、極性の高い溶剤によって抽出された抽出物の溶剤除去物が特に好ましく例示できる。極性の高い溶剤としては、ジエチルエーテル、イソプロピルエーテル、テトラヒドロフランなどのエーテル類、塩化メチレン、クロロホルムなどのハロゲン化炭化水素類、酢酸エチル、蟻酸メチルなどのエステル類、アセトンやメチルエチルケトン等のケトン類、アセトニトリルなどのニトリル類、１，３−ブタンジオール、エタノール、イソプロピルアルコールなどのアルコール類、水などが好ましく例示できる。これらの内では、アルコール及び／又は水が特に好ましい。抽出は、植物体に対して１〜１０重量倍の溶剤を加え、室温であれば数日間、沸点付近の温度であれば数時間浸漬すればよい。抽出後は、必要に応じて、減圧濃縮などして溶剤を除去することが好ましい。以下にエキスの製造例を示す。
【０００７】
＜製造例１＞
桑の葉の乾燥物１ｋｇに、５０％エタノール水溶液１０ｌを加え、３時間加熱還流した。室温まで反応液を冷却した後、濾過により不溶物を取り除き、減圧濃縮した後、水１ｌを加え、分散させた後、凍結乾燥し、エキス(アモルファス)を３７ｇ得た。又、不溶物を乾燥し、重量を量ったところ、９５３ｇあった。
【０００８】
本発明の食品組成物に於いて、α−グルコシダーゼ阻害剤としては、乾燥物を含む桑の葉及び桑の葉エキスの両方を組み合わせて含有する。本発明の食品組成物に於いては、桑の葉エキスを２０〜３０質量％と、桑の葉の乾燥物を１５〜２０質量％とを含有する。この様な形態に於いては有効成分が、段階的に放出される為、有効成分の生体利用性が高まる為と、有効成分以外の部分が非消化素材として有用に働く為である。また、この様な配合量において、α−グルコシダーゼ阻害活性が有効に発揮される為である。
【０００９】
（２）本発明の食品組成物の必須成分であるストレス緩和剤
本発明の食品組成物はストレス緩和剤としてカルシウムを含有することを特徴とする。本発明においてストレス緩和剤は、ダイエット行為に付随して、ダイエット行為者に誘起されるストレスを緩和し、ダイエット行為が中断されるのを防ぐ作用を有する。ダイエット行為が維持されることにより、α−グルコシダーゼ阻害剤の本来の作用が発揮される。ストレス緩和剤としてのカルシウムとしては、乳清カルシウムが特に好適に例示できる。この様な乳清カルシウムとしては、既に市販されているものがあり、この様な市販品を利用することが出来る。好ましい市販品としては、例えば、株式会社ヘルスウェイ社から販売されている「食用乳清カルシウム」が好適に例示できる。かかるストレス緩和剤としてのカルシウムの好ましい含有量は、食品組成物全量に対して、１〜１０質量％が好ましい。これは少なすぎるとストレスが緩和されきれずダイエット行為が中断される場合があり、多すぎても効果が頭打ちになり、処方の自由度を阻害する場合があるからである。
【００１０】
（３）本発明の食品組成物の好ましい成分である非消化性素材
本発明の食品組成物は好ましい形態に於いて、非消化性素材を好ましい成分として含有する。該非消化性素材としては、人間の消化管において消化されないものであれば特段の限定なく適用でき、例えば、キチン、キトサン、マルチトールの様な還元麦芽糖、異性化転化糖、結晶セルロース、ペクチン等のオリゴ糖等が例示できる。このうち、キチン、キトサンは甲殻類の甲殻を抽出、精製することにより得ることが出来る。マルチトールは、麦芽糖を水素添加し、還元することにより得ることが出来る。これらの非消化性成分は既に食品原料として市販されているものが存在し、それらを利用することが出来る。好ましい市販品としては、キトサンである、「キトサンＦＭ−８０」（甲陽ケミカル株式会社製）、マルチトールである「アマルティーＭＲ−５０」（東和化成工業株式会社製）、「マビット」（林原株式会社）、結晶セルロースである「ビバピュール（ＶＩＶＡＰＵＲ）」（リバソン株式会社販売）、「アビセル」（旭化成工業株式会社製）等が好ましく例示できる。又、桑の葉又は桑の葉の乾燥物などのセルロースなどの不溶成分は非消化性素材に分類される。これらの非消化性素材は、本発明の食品組成物に於いて、物理的に腸壁をコートし、糖質の吸収を抑制する効果と、満腹感を催させる作用を有する。本発明の食品組成物において、かかる非消化性素材は唯一種を含有することも出来るし、二種以上組み合わせて含有することも出来る。本発明の食品組成物に於ける非消化性素材の好ましい含有量は、食品組成物全量に対して、総量で、３０〜６０質量％である。これらの内、好ましい形態は、少なくともキトサンを含有する形態であり、更に好ましくは、キトサン、マルチトール及び結晶セルロースを含有する形態である。かかる場合に於けるキトサンの好ましい含有量は、１〜５質量％であり、マルチトールの好ましい含有量は、１５〜３０質量％であり、結晶セルロースの好ましい含有量は、１０〜２０質量％である。これは少なすぎると糖質の吸収を抑制する効果と、満腹感誘起効果などの効果を奏さない場合があり、多すぎると１−デオキシノジリマイシンやカルシウムなどの吸収を阻害する場合があるからである。前記の如くに非消化性素材を組み合わせて用いることにより、有効成分の吸収阻害を最大限抑えて、糖質の吸収を抑制する効果と、満腹感誘起効果を奏させることが可能である。
【００１１】
（４）本発明の食品組成物
本発明の食品組成物は、前記必須成分と好ましい成分とを含有することを特徴とする。本発明の食品組成物は、飴、ガム、焼き菓子などの菓子やソーセージ、ハム、はんぺん、インスタントラーメン等の総菜などの通常の食品や、健康維持や健康促進を目的とする、錠剤や顆粒剤、カプセル剤形式の健康食品或いは特定保健用食品などが好ましく例示できる。このうち、健康維持や健康促進を目的とする、錠剤や顆粒剤、カプセル剤形式の健康食品或いは特定保健用食品が特に好ましい。これは、本発明の食品の効果が、糖質の消化を阻害し、血糖値の急激な上昇が抑制し、その結果、血糖値の上昇がゆるやかになることでインスリンの分泌量も減少し、脂肪細胞での脂肪の合成量が減少し肥満を予防あるいは改善する作用を発揮する。従って、本発明の食品組成物は、食事の直前、具体的には食前３０分以内に予め摂取しておくことが好ましい。用途も血糖値上昇抑制、カロリーの過剰摂取抑制の意味でのダイエット用として用いられる。本発明の食品組成物は、ダイエットの際に生じる、ストレスを緩和し、ダイエットが中断されるのを防ぐ作用を有する。本発明の食品組成物では、前記の必須成分、好ましい成分以外に、通常食品組成物で使用される任意成分を含有することが出来る。かかる任意成分としては、例えば、結合剤、被覆剤、崩壊剤、糖衣剤、カプセル剤、矯味矯臭剤、着色剤、安定化剤、分散剤などが好ましく例示できる。本発明の食品組成物は、前記必須成分、好ましい成分、任意成分を常法に従って処理することにより、製造することが出来る。
【００１２】
【実施例】
以下に、実施例を挙げて、本発明について更に詳細に説明を加えるが、本発明が、かかる実施例にのみ限定されないことは言うまでもない。
【００１３】
＜実施例１＞
下記に示す処方に従って、本発明の食品組成物（健康食品）を作製した。即ち、処方成分をフローコーターに仕込み、流動層造粒を行い、４０℃で送風乾燥し、顆粒を得た。この顆粒を打錠し、２２０ｍｇの錠剤として、本発明の食品組成物１を得た。
製造例１の桑の葉エキス ２５ 質量部
桑の葉の乾燥・粉砕物 １８ 質量部
キトサン ４ 質量部
マルチトール ２１ 質量部
結晶セルロース １８ 質量部
ヒドロキシプロピルセルロース ４ 質量部
ショ糖脂肪酸エステル ５ 質量部
乳清カルシウム ５ 質量部
【００１４】
＜参考例１＞
下記に示す処方に従って、参考例の食品組成物(健康食品)を作製した。即ち、処方成分をフローコーターに仕込み、流動層造粒を行い、４０℃で送風乾燥し、顆粒を得た。この顆粒を打錠し、２２０ｍｇの錠剤として、食品組成物２を得た。
製造例１の桑の葉エキス ３３ 質量部
キトサン ４ 質量部
マルチトール ２１ 質量部
結晶セルロース １８ 質量部
ヒドロキシプロピルセルロース ４ 質量部
ショ糖脂肪酸エステル ５ 質量部
乳清カルシウム ５ 質量部
【００１５】
＜試験例１＞
実施例１、参考例１の食品組成物１、２を用いて、血糖値に対する作用を調べた。即ち、肥満に悩むパネラー１群５名を用い、５０ｇのショ糖の摂取後の血糖値の変化を調べた。１群はショ糖の投与のみで食品組成物は投与せず(対照群)、１群はショ糖投与の２０分前に食品組成物１を２錠投与し(食品組成物１前投与群)、１群はショ糖投与の２０分前に食品組成物２を２錠投与し(食品組成物２前投与群)、残る１群はショ糖投与の直後に食品組成物１を２錠投与した(食品組成物１後投与群)。ショ糖は１８０ｍｌの温水に溶かして投与した。実験直前及びショ糖投与後３０分に採血し、血糖値(ｍｇ／ｄｌ)を測定した。結果を表１に示す。これより、本発明の食品組成物は、食事前に投与することにより、糖質の消化、吸収を抑制し、肥満を防止する作用を有することがわかる。又、α−グルコシダーゼ阻害剤として、桑の葉エキスと桑の葉の乾燥、粉砕物の両方を含有する形態が好ましいこともわかる。
【００１６】
【表１】
＜実施例２＞
下記に示す処方に従って、本発明の食品組成物(健康食品)を作製した。即ち、処方成分をフローコーターに仕込み、流動層造粒を行い、４０℃で送風乾燥し、顆粒を得た。この顆粒を打錠し、２２０ｍｇの錠剤として、本発明の食品組成物３を得た。試験例１と同様の評価を行ったところ、直前の血糖値が９９±１０ｍｇ／ｄｌであり、３０分後の血糖値が、１３７±２１ｍｇ／ｄｌであった。この結果と試験例１の結果を比較すると、非消化性素材として、キトサン、マルチトール及び結晶セルロースを含有する形態が好ましいことがわかる。
製造例１の桑の葉エキス ２５ 質量部
桑の葉の乾燥・粉砕物 １８ 質量部
キトサン ４３ 質量部
ヒドロキシプロピルセルロース ４ 質量部
ショ糖脂肪酸エステル ５ 質量部
乳清カルシウム ５ 質量部
【００１８】
＜試験例２＞
食品組成物１と食品組成物１の乳清カルシウムを結晶セルロースに置換した、比較例１とを用いて、肥満に悩むヒトをパネラーとして、（１群５名）ダイエット使用テストを行った。テストは５週間行い、一日３回食事前３０分にサンプルを２錠服用してもらった。又、服用忘れもチェックしてもらった。試験開始時と終了時に体重を測定してもらった。結果を、試験開始時の平均体重、試験終了時の平均体重、服用忘れ回数として表２示す。これより、本発明の食品組成物１では、体重減少が認められたのに、比較例の群では認められないことがわかる。この原因としては、本発明の食品組成物１では、殆ど服用忘れがないのに、比較例１では５０％を越えている為であると考えられる。これは、乳清カルシウムを配合することにより、本発明の食品組成物１ではストレスが緩和され、自然体でダイエットが出来るのに比し、比較例１では、被験者がダイエットのストレスを感じる為、服用忘れが起こるものと思われる。
（比較例１）
製造例１の桑の葉エキス ２５ 質量部
桑の葉の乾燥・粉砕物 １８ 質量部
キトサン ４ 質量部
マルチトール ２１ 質量部
結晶セルロース ２３ 質量部
ヒドロキシプロピルセルロース ４ 質量部
ショ糖脂肪酸エステル ５ 質量部
製法）処方成分をフローコーターに仕込み、流動層造粒を行い、４０℃で送風乾燥し、顆粒を得た。この顆粒を打錠し、２２０ｍｇの錠剤として、比較例１の食品組成物を得た。
【００１９】
【表２】
【発明の効果】
本発明によれば、α−グルコシダーゼ阻害剤を含有するダイエット用の食品組成物に於いて、その摂取の継続性を改善する技術を提供することができる。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a food composition for diet.
[0002]
[Prior art]
In recent years, various social factors such as changes in nutritional status, changes in dietary habits, and chronic lack of exercise overlap, and obesity or excessive caloric intake has become a major social problem. There is a concern that such excessive caloric intake and obesity caused by it may cause diabetes, hyperlipidemia, syndrome X, etc., and develop into these adult diseases. It has become a serious issue. Various measures for preventing obesity have been devised against the background of such social circumstances. For example, a non-digestible gel composition such as glucomannan is administered before a meal to physically limit the amount of meal , or an α-glucosidase inhibitor such as 1-deoxynojirimycin is administered to digest a carbohydrate. to suppress, by using, for example, overdose suppressing method and chitosan and Gymnema sylvestre extract calories inhibit the absorption of carbohydrates, is that known a method of suppressing the excessive intake of calories ( JP-A-6-181702, JP-A-2000-28183, JP-A-2001-103928 ). However, the reason why no definitive thing has appeared in these is that the continuity of the diet is difficult. That is, it can be said that, in any material, although the effect of excessive intake of calories is recognized, it is not effective that it cannot be continuously ingested until it becomes effective. In other words, it has been desired to develop means for maintaining the continuity of intake in diet foods.
[0003]
On the other hand, the calcium, Ri you already been known to have an effect to relax the stress (JP-A 7-308147, JP-2000-7573, JP-2002-119250), of such calcium in whey present, whey calcium, especially absorption, is excellent in bioavailability that is known (JP-2001-95488). However, it is not known at all to be contained in diet foods for the purpose of improving the continuity of the intake. Therefore, it is not known at all that a food composition containing 1) an α-glucosidase inhibitor and 2) a stress relieving agent is excellent in continuity of intake and suppression of excessive intake of calories.
[0004]
[Problems to be solved by the invention]
The present invention has been made under such circumstances, and an object of the present invention is to provide a technique for improving the continuity of intake in a food composition for diets containing an α-glucosidase inhibitor. To do.
[0005]
[Means for solving problems]
In view of such circumstances, the present inventors have intensively researched for a means for improving the continuity of intake in a food composition for diets containing an α-glucosidase inhibitor. As a result, it was found that the continuation of intake of the dietary food composition is a stress of recognition that the diet is being executed, and the continuity can be maintained by alleviating the stress. That is, the present inventors have found that a food composition containing 1) an α-glucosidase inhibitor and 2) a stress relieving agent has suitable properties as a food for diet, and has completed the invention. That is, this invention relates to the technique shown below. (1) 1) Food for diet, comprising as an α-glucosidase inhibitor an extract from mulberry leaves and alcohol and / or water from mulberry leaves, and 2) calcium as a stress relieving agent A composition comprising 15 to 20% by weight of a dried product of mulberry leaves based on the total amount of the food composition, and 20 to 20% of an extract extracted from alcohol and / or water from the mulberry leaves based on the total amount of the food composition A food composition comprising 30% by mass.
(2) The food composition for diet according to (1), wherein the calcium is whey calcium.
(3) The food composition for diet according to (1) or (2), further comprising chitosan as a non-digestible material.
(4) The food composition for diet according to any one of (1) to (3), further comprising maltitol and / or crystalline cellulose as a non-digestible material.
[0006]
DETAILED DESCRIPTION OF THE INVENTION
(1) α-Glucosidase inhibitor which is an essential component of the food composition of the present invention The food composition of the present invention is characterized by containing mulberry leaves and mulberry leaf extract as α-glucosidase inhibitors. An α-glucosidase inhibitor inhibits a rapid increase in blood glucose level by inhibiting the process of breaking down carbohydrates in food into glucose. As a result, the increase in blood glucose level is moderated, so that the amount of insulin secreted is also reduced, the amount of fat synthesized in fat cells is reduced, and obesity can be prevented or improved. The α- glucosidase inhibitor, such as 1-deoxynojirimycin Maishi emissions are listed et al is, 1-deoxynojirimycin is included in mulberry leaves and the like. Immediate Chi, used in the mulberry leaves and mulberry leaves equi scan and α- glucosidase inhibitor of the present invention. Extract and is here, extract some or all extracted with a solvent of the plant, the solvent removed substance by removing the solvent from the extract, the extract or the fractions prepared by fractionation purified solvent removed substance Means generic name. As the extract, a solvent-removed product of the extract extracted with a highly polar solvent can be particularly preferably exemplified. Examples of highly polar solvents include ethers such as diethyl ether, isopropyl ether and tetrahydrofuran, halogenated hydrocarbons such as methylene chloride and chloroform, esters such as ethyl acetate and methyl formate, ketones such as acetone and methyl ethyl ketone, acetonitrile Preferred examples include nitriles such as 1,3-butanediol, alcohols such as ethanol and isopropyl alcohol, and water. Among these, alcohol and / or water are particularly preferable. Extraction may be performed by adding 1 to 10 times the weight of the solvent to the plant body and immersing for several days at room temperature and for several hours at a temperature near the boiling point. After extraction, it is preferable to remove the solvent by vacuum concentration or the like, if necessary. The production example of the extract is shown below.
[0007]
<Production Example 1>
To 1 kg of dried mulberry leaves, 10 l of a 50% ethanol aqueous solution was added and heated to reflux for 3 hours. After cooling the reaction solution to room temperature, insolubles were removed by filtration and concentrated under reduced pressure. Then, 1 l of water was added and dispersed, and then lyophilized to obtain 37 g of extract (amorphous) . The insoluble material was dried and weighed to find 953 g.
[0008]
In the food composition of the present invention, the α- glucosidase inhibitor, it contains a combination of both mulberry leaves and mulberry leaf extract containing dry matter. The food composition of the present invention contains 20 to 30% by mass of mulberry leaf extract and 15 to 20% by mass of dried mulberry leaf . Active ingredient In such form of this is, because it is stepwise release, and for bioavailability of the active ingredient increases, is because the portion other than the active ingredient acts useful as non-digestible material. Further, in the amount such as this, it is because α- glucosidase inhibiting activity is effectively exhibited.
[0009]
(2) Stress relieving agent which is an essential component of the food composition of the present invention The food composition of the present invention is characterized by containing calcium as a stress relieving agent. In the present invention, the stress relieving agent has a function of relieving stress induced by a diet actant and preventing the diet act from being interrupted in association with the diet act. By maintaining the diet action, the original action of the α-glucosidase inhibitor is exhibited. As calcium as the stress relieving agent , whey calcium can be particularly preferably exemplified. As such whey calcium, there is one already marketed, and such a commercial product can be used. Preferable examples of commercially available products include “edible whey calcium” sold by Healthway, Inc. The preferable content of calcium as the stress relieving agent is preferably 1 to 10% by mass with respect to the total amount of the food composition. This is because if the amount is too small, the stress cannot be alleviated and the dieting action may be interrupted. If the amount is too large, the effect will reach its peak and the prescription freedom may be hindered.
[0010]
(3) Non-digestible material which is a preferred component of the food composition of the present invention In a preferred form, the food composition of the present invention contains a non-digestible material as a preferred component. The non-digestible material can be applied without particular limitation as long as it is not digested in the human digestive tract, such as reduced maltose such as chitin, chitosan, maltitol, isomerized invert sugar, crystalline cellulose, pectin, etc. Examples include oligosaccharides. Of these, chitin and chitosan can be obtained by extracting and purifying crustacean shells. Maltitol can be obtained by hydrogenating maltose and reducing it. Some of these non-digestible components are already commercially available as food materials, and they can be used. Preferable commercially available products include chitosan “chitosan FM-80” (manufactured by Koyo Chemical Co., Ltd.), maltitol “Amarty MR-50” (manufactured by Towa Kasei Kogyo Co., Ltd.), “mabit” (Hayashibara Co., Ltd.) Company), “Vivapur” (sold by Ribason Co., Ltd.) and “Avicel” (manufactured by Asahi Kasei Kogyo Co., Ltd.), which are crystalline cellulose, can be preferably exemplified. Further, the insoluble component such as dry matter of which cellulose mulberry leaves or mulberry leaves are classified as non-digestible material. In the food composition of the present invention, these non-digestible materials have an effect of physically coating the intestinal wall to suppress the absorption of carbohydrates and a feeling of fullness. In the food composition of the present invention, such a non-digestible material can contain a single species, or can be contained in combination of two or more. The preferred content of at indigestible material in the food composition of the present invention is to provide a food composition the total amount, in total, Ru 3 0-60% by mass. Of these, preferred forms are forms containing at least chitosan emissions, more preferably form containing chitosan, maltitol and crystalline cellulose. In such a case, the preferred content of chitosan is 1-5% by mass, the preferred content of maltitol is 15-30% by mass, and the preferred content of crystalline cellulose is 10-20% by mass. is there. This is because if the amount is too small, the effect of suppressing carbohydrate absorption and the effect of inducing satiety may not be achieved. If the amount is too large, the absorption of 1-deoxynojirimycin or calcium may be inhibited. is there. By using a combination of non-digestible materials as described above, it is possible to suppress the absorption of the active ingredient to the maximum, suppress the carbohydrate absorption, and achieve a satiety-inducing effect.
[0011]
(4) Food composition of this invention The food composition of this invention contains the said essential component and a preferable component, It is characterized by the above-mentioned. The food composition of the present invention is a normal food such as sweets such as candy, gum, baked confectionery, sausages, ham, hampen, instant ramen, etc., and tablets and granules for the purpose of maintaining health and promoting health. Preferred examples include capsule-type health foods and foods for specified health use. Of these, health foods in the form of tablets, granules, capsules or foods for specified health use for the purpose of maintaining health and promoting health are particularly preferred. This is because the effect of the food of the present invention inhibits the digestion of carbohydrates, suppresses a rapid increase in blood glucose level, and as a result, the increase in blood glucose level becomes gradual, thereby reducing the amount of insulin secreted, Reduces the amount of fat synthesized in adipocytes and exerts an effect of preventing or improving obesity. Therefore, the food composition of the present invention is preferably taken in advance immediately before a meal, specifically within 30 minutes before a meal. The use is also used for diet in the sense of suppressing blood sugar level elevation and excessive intake of calories . The food composition of this invention has the effect | action which relieve | moderates the stress which arises at the time of a diet, and prevents a diet being interrupted. In the food composition of the present invention, in addition to the above essential components and preferred components, optional components usually used in food compositions can be contained. Preferred examples of such optional components include binders, coating agents, disintegrants, sugar coatings, capsules, flavoring agents, coloring agents, stabilizers, and dispersing agents. The food composition of this invention can be manufactured by processing the said essential component, a preferable component, and an arbitrary component in accordance with a conventional method.
[0012]
【Example】
Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to such examples.
[0013]
<Example 1>
According to the prescription shown below, the food composition (health food) of the present invention was prepared . That is, prescription ingredients were charged into a flow coater, fluidized bed granulation was performed, and air drying was performed at 40 ° C. to obtain granules. This granule was tableted to obtain a food composition 1 of the present invention as a 220 mg tablet.
Mulberry leaf extract of Production Example 1 25 parts by weight Dried and ground product of mulberry leaves 18 parts by weight chitosan 4 parts by weight maltitol 21 parts by weight crystalline cellulose 18 parts by weight hydroxypropyl cellulose 4 parts by weight sucrose fatty acid ester 5 parts by weight milk Purified calcium 5 parts by mass [0014]
< Reference Example 1 >
Follow the formulations shown below were prepared food composition in the reference example (health food). That is, prescription ingredients were charged into a flow coater, fluidized bed granulation was performed, and air drying was performed at 40 ° C. to obtain granules. The granules were tableted by a tablet of 220 mg, to obtain a food composition 2.
Mulberry leaf extract of Production Example 1 33 parts by weight chitosan 4 parts by weight maltitol 21 parts by weight crystalline cellulose 18 parts by weight hydroxypropyl cellulose 4 parts by weight sucrose fatty acid ester 5 parts by weight whey calcium 5 parts by weight
<Test Example 1>
Using the food compositions 1 and 2 of Example 1 and Reference Example 1, the effect on blood glucose level was examined. That is, 5 panelists suffering from obesity were examined for changes in blood glucose level after ingestion of 50 g of sucrose. Group 1 is administered only sucrose and not food composition (control group), Group 1 is administered 2 tablets of food composition 1 20 minutes before sucrose administration (food composition 1 pre-administration group) One group administered 2 tablets of food composition 2 20 minutes before sucrose administration (food composition 2 pre-administration group), and the remaining group administered 2 tablets of food composition 1 immediately after sucrose administration (Food composition 1 post-administration group). Sucrose was administered after being dissolved in 180 ml of warm water. Blood was collected immediately before the experiment and 30 minutes after sucrose administration, and the blood glucose level (mg / dl) was measured. The results are shown in Table 1. From this, it can be seen that the food composition of the present invention has the action of inhibiting digestion and absorption of carbohydrates and preventing obesity when administered before meals. Also, alpha-glucosidase as an inhibitor, dry mulberry flies Kiss mulberry leaves, it can also be seen the preferred form containing both the granulated material.
[0016]
[Table 1]
<Example 2 >
A food composition (health food) of the present invention was prepared according to the formulation shown below. That is, prescription ingredients were charged into a flow coater, fluidized bed granulation was performed, and air drying was performed at 40 ° C. to obtain granules. This granule was tableted to obtain a food composition 3 of the present invention as a 220 mg tablet. When the same evaluation as in Test Example 1 was performed, the blood glucose level immediately before was 99 ± 10 mg / dl, and the blood glucose level after 30 minutes was 137 ± 21 mg / dl. When this result is compared with the result of Test Example 1, it can be seen that a form containing chitosan, maltitol and crystalline cellulose is preferable as the non-digestible material.
Mulberry leaf extract of Production Example 1 25 parts by weight Dried and pulverized mulberry leaves 18 parts by weight chitosan 43 parts by weight hydroxypropylcellulose 4 parts by weight sucrose fatty acid ester 5 parts by weight whey calcium 5 parts by weight
<Test Example 2>
A diet use test was conducted using food composition 1 and Comparative Example 1 in which whey calcium in food composition 1 was replaced with crystalline cellulose, with humans suffering from obesity as panelists (5 people per group). The test was conducted for 5 weeks, and 2 samples were taken 3 times a day 30 minutes before meals. They also checked for missed doses. They were weighed at the start and end of the study. The results are shown in Table 2 as the average weight at the start of the test, the average weight at the end of the test, and the number of missed doses. From this, it can be seen that in the food composition 1 of the present invention, weight loss was observed but not in the group of comparative examples. This is probably because the food composition 1 of the present invention almost never forgot to be taken, but the comparative example 1 exceeded 50%. This is because, by adding whey calcium, the food composition 1 of the present invention is less stressed and can be dieted naturally, whereas in Comparative Example 1, the subject feels the stress of dieting. It seems that forgetting happens.
(Comparative Example 1)
Mulberry leaf extract of Production Example 1 25 parts by weight Dried and pulverized mulberry leaves 18 parts by weight chitosan 4 parts by weight maltitol 21 parts by weight crystalline cellulose 23 parts by weight hydroxypropylcellulose 4 parts by weight sucrose fatty acid ester 5 parts by weight ) The formulation components were charged into a flow coater, fluidized bed granulated, and blown dry at 40 ° C. to obtain granules. The granules were tableted to obtain a food composition of Comparative Example 1 as 220 mg tablets.
[0019]
[Table 2]
【The invention's effect】
ADVANTAGE OF THE INVENTION According to this invention, the technique which improves the continuation of the intake can be provided in the food composition for diet containing an alpha-glucosidase inhibitor.
Claims (4)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002383336A JP4316234B2 (en) | 2002-12-17 | 2002-12-17 | Diet food |
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| Application Number | Priority Date | Filing Date | Title |
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| JP2002383336A JP4316234B2 (en) | 2002-12-17 | 2002-12-17 | Diet food |
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| JP2004194635A JP2004194635A (en) | 2004-07-15 |
| JP2004194635A5 JP2004194635A5 (en) | 2005-12-15 |
| JP4316234B2 true JP4316234B2 (en) | 2009-08-19 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101326002B1 (en) | 2012-02-02 | 2013-11-07 | 배용석 | Composition for use of reducing and controlling blood glucose for improving diabetes |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008535919A (en) * | 2005-04-11 | 2008-09-04 | ユニバーシティ オブ テネシー リサーチ ファウンデーション | Stable milk ingredients that are effective in reducing fat |
| JP2009249315A (en) | 2008-04-03 | 2009-10-29 | Fujifilm Corp | Mineral absorption promoter, and iron deficiency anemia-ameliorating agent or food composition |
| CN102018766B (en) | 2009-09-16 | 2013-03-06 | 博仲盛景医药技术（北京）有限公司 | Plant extractive, extraction method and application thereof as well as composite comprising same |
| JP5752359B2 (en) * | 2010-02-25 | 2015-07-22 | 富士フイルム株式会社 | Weight gain inhibiting composition and food containing the same |
| JP2011057707A (en) * | 2010-12-21 | 2011-03-24 | Nagasakiken Koritsu Daigaku Hojin | Composition for suppressing blood glucose level increase, food for suppressing blood glucose level increase, and composition for inhibiting disaccharide hydrolase activity |
| ITUB20153328A1 (en) * | 2015-09-01 | 2017-03-01 | Akademy Pharma S R L | NUTRACEUTICAL COMPOUND AGAINST THE SYMPTOMS OF THE MENOPAUSE |
| JP2019127439A (en) * | 2018-01-22 | 2019-08-01 | 株式会社お茶村 | Supplement comprising morus alba leaves |
| JP6638123B1 (en) * | 2019-05-29 | 2020-01-29 | サントリーホールディングス株式会社 | Beverage containing 1-deoxynojirimycin |
| JP2023074085A (en) * | 2021-11-17 | 2023-05-29 | 小林製薬株式会社 | Oral composition containing processed mulberry leaf |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR101326002B1 (en) | 2012-02-02 | 2013-11-07 | 배용석 | Composition for use of reducing and controlling blood glucose for improving diabetes |
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