KR20130083915A - Gpr119 조절제로서의 4-(5-시아노-피라졸-1-일)-피페리딘 유도체 - Google Patents
Gpr119 조절제로서의 4-(5-시아노-피라졸-1-일)-피페리딘 유도체 Download PDFInfo
- Publication number
- KR20130083915A KR20130083915A KR1020137013064A KR20137013064A KR20130083915A KR 20130083915 A KR20130083915 A KR 20130083915A KR 1020137013064 A KR1020137013064 A KR 1020137013064A KR 20137013064 A KR20137013064 A KR 20137013064A KR 20130083915 A KR20130083915 A KR 20130083915A
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- cyano
- carboxylate
- pyrazol
- piperidine
- Prior art date
Links
- HZHVNRRMSFVLSH-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1NN)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1NN)=O HZHVNRRMSFVLSH-UHFFFAOYSA-N 0.000 description 1
- OXJHOZLEMKDECM-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1[n]1ncc(CO)c1C#N)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1[n]1ncc(CO)c1C#N)=O OXJHOZLEMKDECM-UHFFFAOYSA-N 0.000 description 1
- PRBNKVOYFVGRLP-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1[n]1ncc(COc(c(F)c2)ccc2C#N)c1C#N)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1[n]1ncc(COc(c(F)c2)ccc2C#N)c1C#N)=O PRBNKVOYFVGRLP-UHFFFAOYSA-N 0.000 description 1
- RQYZQBGMXOPWKY-UHFFFAOYSA-N CC(C)(C)OC(N(CCC1NN)CC1O)=O Chemical compound CC(C)(C)OC(N(CCC1NN)CC1O)=O RQYZQBGMXOPWKY-UHFFFAOYSA-N 0.000 description 1
- NRUPMGFWLSKYCT-IRXDYDNUSA-N CC(C)(C)OC(N(CC[C@@H]1[n]2ncc(COc3c(C)nccc3)c2C#N)C[C@@H]1F)=O Chemical compound CC(C)(C)OC(N(CC[C@@H]1[n]2ncc(COc3c(C)nccc3)c2C#N)C[C@@H]1F)=O NRUPMGFWLSKYCT-IRXDYDNUSA-N 0.000 description 1
- ZTRQYTYHPJMVDZ-UHFFFAOYSA-N CC(C)OC(N(CC1)CCC1[n]1ncc(COc(c(C#N)c2)ccc2F)c1C#N)=O Chemical compound CC(C)OC(N(CC1)CCC1[n]1ncc(COc(c(C#N)c2)ccc2F)c1C#N)=O ZTRQYTYHPJMVDZ-UHFFFAOYSA-N 0.000 description 1
- WDCVWDNIINRGKG-UHFFFAOYSA-N CC(C)OC(N(CC1)CCC1[n]1ncc(COc(ccc(F)c2)c2F)c1C#N)=O Chemical compound CC(C)OC(N(CC1)CCC1[n]1ncc(COc(ccc(F)c2)c2F)c1C#N)=O WDCVWDNIINRGKG-UHFFFAOYSA-N 0.000 description 1
- SIZTWPADYPGDSN-UHFFFAOYSA-N CC(C)OC(N(CC1)CCC1[n]1ncc(COc2ccccc2C)c1C#N)=O Chemical compound CC(C)OC(N(CC1)CCC1[n]1ncc(COc2ccccc2C)c1C#N)=O SIZTWPADYPGDSN-UHFFFAOYSA-N 0.000 description 1
- KUXPLCHIQOWADQ-UHFFFAOYSA-N CC(c(c(F)c1)ccc1S(C)(=O)=O)=C Chemical compound CC(c(c(F)c1)ccc1S(C)(=O)=O)=C KUXPLCHIQOWADQ-UHFFFAOYSA-N 0.000 description 1
- KLSLUQZBAVDFHO-UHFFFAOYSA-N CC1(CC1)OC(N(CC1)CCC1[n]1ncc(COC(CC2)CCN2S(C)(=O)=O)c1C#N)=O Chemical compound CC1(CC1)OC(N(CC1)CCC1[n]1ncc(COC(CC2)CCN2S(C)(=O)=O)c1C#N)=O KLSLUQZBAVDFHO-UHFFFAOYSA-N 0.000 description 1
- FTDIZKGIIMWHFF-UHFFFAOYSA-N CC1(CC1)OC(N(CC1)CCC1[n]1ncc(COc(cccc2F)c2F)c1C#N)=O Chemical compound CC1(CC1)OC(N(CC1)CCC1[n]1ncc(COc(cccc2F)c2F)c1C#N)=O FTDIZKGIIMWHFF-UHFFFAOYSA-N 0.000 description 1
- NEFQIPKACPCKJC-DLBZAZTESA-N CC1(CC1)OC(N(CC[C@H]1[n]2ncc(COc3c(C)nccc3)c2C#N)C[C@@H]1F)=O Chemical compound CC1(CC1)OC(N(CC[C@H]1[n]2ncc(COc3c(C)nccc3)c2C#N)C[C@@H]1F)=O NEFQIPKACPCKJC-DLBZAZTESA-N 0.000 description 1
- SFWORIUDBFNINU-UHFFFAOYSA-N CCc1cnc(N(CC2)CCC2[n]2ncc(COc(c(F)c3)ccc3C#N)c2C#N)nc1 Chemical compound CCc1cnc(N(CC2)CCC2[n]2ncc(COc(c(F)c3)ccc3C#N)c2C#N)nc1 SFWORIUDBFNINU-UHFFFAOYSA-N 0.000 description 1
- VNGFHIKHZBKLRB-UHFFFAOYSA-N CCc1cnc(N(CC2)CCC2[n]2ncc(COc(c(F)c3)ccc3C(N(C)C)=O)c2C#N)nc1 Chemical compound CCc1cnc(N(CC2)CCC2[n]2ncc(COc(c(F)c3)ccc3C(N(C)C)=O)c2C#N)nc1 VNGFHIKHZBKLRB-UHFFFAOYSA-N 0.000 description 1
- OQVNGKRWXJDCCM-UHFFFAOYSA-N C[Si](C)(C)OCC[n]1nnc(-c(cc2)cc(F)c2O)n1 Chemical compound C[Si](C)(C)OCC[n]1nnc(-c(cc2)cc(F)c2O)n1 OQVNGKRWXJDCCM-UHFFFAOYSA-N 0.000 description 1
- SHAPDKYVJFGHSO-GXTWGEPZSA-N Cc1c(N(C2)Cc3c2cn[n]3C)ncnc1O[C@H](CCNC1)[C@H]1F Chemical compound Cc1c(N(C2)Cc3c2cn[n]3C)ncnc1O[C@H](CCNC1)[C@H]1F SHAPDKYVJFGHSO-GXTWGEPZSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41644110P | 2010-11-23 | 2010-11-23 | |
| US61/416,441 | 2010-11-23 | ||
| PCT/IB2011/054996 WO2012069948A1 (en) | 2010-11-23 | 2011-11-09 | 4- (5-cyano-pyrazol-1-yl) -piperidine derivatives as gpr 119 modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20130083915A true KR20130083915A (ko) | 2013-07-23 |
Family
ID=45418722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137013064A KR20130083915A (ko) | 2010-11-23 | 2011-11-09 | Gpr119 조절제로서의 4-(5-시아노-피라졸-1-일)-피페리딘 유도체 |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP2643310A1 (ja) |
| JP (1) | JP2013543885A (ja) |
| KR (1) | KR20130083915A (ja) |
| CN (1) | CN103298801A (ja) |
| AP (1) | AP2013006809A0 (ja) |
| AR (1) | AR088121A1 (ja) |
| AU (1) | AU2011333427A1 (ja) |
| BR (1) | BR112013011865A2 (ja) |
| CA (1) | CA2814231A1 (ja) |
| CL (1) | CL2013001054A1 (ja) |
| CO (1) | CO6801716A2 (ja) |
| CR (1) | CR20130139A (ja) |
| CU (1) | CU20130059A7 (ja) |
| DO (1) | DOP2013000102A (ja) |
| EA (1) | EA201370118A1 (ja) |
| EC (1) | ECSP13012630A (ja) |
| GT (1) | GT201300135A (ja) |
| MA (1) | MA34805B1 (ja) |
| MX (1) | MX2013004083A (ja) |
| NI (1) | NI201300044A (ja) |
| PE (1) | PE20140409A1 (ja) |
| SG (1) | SG189830A1 (ja) |
| TW (1) | TWI433843B (ja) |
| UY (1) | UY33742A (ja) |
| WO (1) | WO2012069948A1 (ja) |
| ZA (1) | ZA201302362B (ja) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6463631B2 (ja) | 2011-06-09 | 2019-02-06 | ライゼン・ファーマシューティカルズ・エスアー | Ｇｐｒ−１１９のモジュレータとしての新規化合物 |
| CN104780915A (zh) | 2012-07-11 | 2015-07-15 | 埃尔舍利克斯治疗公司 | 包含他汀、双胍和用于减小心脏代谢风险的其它药剂的组合物 |
| JP2017119628A (ja) * | 2014-05-09 | 2017-07-06 | 日産化学工業株式会社 | 置換アゾール化合物及び糖尿病治療薬 |
| CN104610151A (zh) * | 2015-02-13 | 2015-05-13 | 佛山市赛维斯医药科技有限公司 | 含酰肼和烷氧苯类结构的化合物、其制备方法及用途 |
| CN104592120A (zh) * | 2015-02-13 | 2015-05-06 | 佛山市赛维斯医药科技有限公司 | 一种环丙基酰肼和甲氧苯类gpr119激动剂、制备方法及其用途 |
| CN104892517A (zh) * | 2015-02-13 | 2015-09-09 | 佛山市赛维斯医药科技有限公司 | 酰肼类化合物、其制备方法及用途 |
| WO2017140771A1 (en) | 2016-02-18 | 2017-08-24 | Syngenta Participations Ag | Pesticidally active pyrazole derivatives |
| CN106631992B (zh) * | 2017-01-05 | 2019-01-18 | 桑迪亚医药技术（上海）有限责任公司 | 一种4-氧-3,4-二氢-2h-吡啶-1-甲酸叔丁酯的合成方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5489997B2 (ja) * | 2007-07-19 | 2014-05-14 | シマベイ セラピューティクス， インコーポレーテッド | 糖尿病および代謝疾患の治療のためのＲＵＰ３またはＧＰＲｌ１９受容体のアゴニストとしてのＮ−アザ環状置換ピロール、ピラゾール、イミダゾール、トリアゾールおよびテトラゾール誘導体 |
| CA2719507C (en) * | 2008-03-31 | 2018-03-27 | Metabolex, Inc. | Oxymethylene aryl compounds and uses thereof |
| BRPI1014636A2 (pt) * | 2009-06-05 | 2016-04-05 | Pfizer | moduladores de gpr 119 |
-
2011
- 2011-11-09 BR BR112013011865A patent/BR112013011865A2/pt not_active IP Right Cessation
- 2011-11-09 CA CA2814231A patent/CA2814231A1/en not_active Abandoned
- 2011-11-09 MA MA35928A patent/MA34805B1/fr unknown
- 2011-11-09 AU AU2011333427A patent/AU2011333427A1/en not_active Abandoned
- 2011-11-09 EA EA201370118A patent/EA201370118A1/ru unknown
- 2011-11-09 JP JP2013540458A patent/JP2013543885A/ja active Pending
- 2011-11-09 EP EP11802149.2A patent/EP2643310A1/en not_active Withdrawn
- 2011-11-09 WO PCT/IB2011/054996 patent/WO2012069948A1/en active Application Filing
- 2011-11-09 PE PE2013001058A patent/PE20140409A1/es not_active Application Discontinuation
- 2011-11-09 SG SG2013023189A patent/SG189830A1/en unknown
- 2011-11-09 KR KR1020137013064A patent/KR20130083915A/ko not_active Application Discontinuation
- 2011-11-09 MX MX2013004083A patent/MX2013004083A/es unknown
- 2011-11-09 CN CN2011800550665A patent/CN103298801A/zh active Pending
- 2011-11-09 AP AP2013006809A patent/AP2013006809A0/xx unknown
- 2011-11-21 UY UY0001033742A patent/UY33742A/es unknown
- 2011-11-22 TW TW100142804A patent/TWI433843B/zh not_active IP Right Cessation
- 2011-11-22 AR ARP110104351A patent/AR088121A1/es not_active Application Discontinuation
-
2013
- 2013-03-22 CR CR20130139A patent/CR20130139A/es unknown
- 2013-04-02 ZA ZA2013/02362A patent/ZA201302362B/en unknown
- 2013-04-16 CL CL2013001054A patent/CL2013001054A1/es unknown
- 2013-04-23 CU CU2013000059A patent/CU20130059A7/es unknown
- 2013-05-09 DO DO2013000102A patent/DOP2013000102A/es unknown
- 2013-05-13 NI NI201300044A patent/NI201300044A/es unknown
- 2013-05-20 EC ECSP13012630 patent/ECSP13012630A/es unknown
- 2013-05-21 GT GT201300135A patent/GT201300135A/es unknown
- 2013-05-23 CO CO13127143A patent/CO6801716A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TWI433843B (zh) | 2014-04-11 |
| CA2814231A1 (en) | 2012-05-31 |
| AR088121A1 (es) | 2014-05-14 |
| DOP2013000102A (es) | 2013-07-15 |
| CR20130139A (es) | 2013-06-28 |
| CO6801716A2 (es) | 2013-11-29 |
| JP2013543885A (ja) | 2013-12-09 |
| NI201300044A (es) | 2013-08-01 |
| AP2013006809A0 (en) | 2013-04-30 |
| MX2013004083A (es) | 2013-06-13 |
| EP2643310A1 (en) | 2013-10-02 |
| CN103298801A (zh) | 2013-09-11 |
| CL2013001054A1 (es) | 2013-09-27 |
| ZA201302362B (en) | 2014-06-25 |
| CU20130059A7 (es) | 2013-06-28 |
| TW201300373A (zh) | 2013-01-01 |
| EA201370118A1 (ru) | 2013-12-30 |
| PE20140409A1 (es) | 2014-03-23 |
| SG189830A1 (en) | 2013-06-28 |
| MA34805B1 (fr) | 2014-01-02 |
| GT201300135A (es) | 2015-02-19 |
| AU2011333427A1 (en) | 2013-04-11 |
| BR112013011865A2 (pt) | 2016-08-23 |
| WO2012069948A1 (en) | 2012-05-31 |
| ECSP13012630A (es) | 2013-07-31 |
| UY33742A (es) | 2012-06-29 |
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| E601 | Decision to refuse application |