KR20130059249A - Mixture used to strengthen immunity - Google Patents

Abstract

PURPOSE: A mixture which is used for enhancing immunity by extracting wild ginseng, Codonopsis pilosulae radix, Astraglaus membranaceus BUNGE, and Gatrodia elata Blume using 50-90% alcohol is provided to prevent aging, to improve memory, to reduce blood pressure, and to enhance fatigue recovery and immunity. CONSTITUTION: A mixture which is used for enhancing immunity comprises: a step of weighing wild ginseng, Codonopsis pilosulae radix, Astraglaus membranaceus BUNGE, and Gatrodia elata Blume, pulverizing and mixing in a weight ratio of 0.2-10:5-250:5-250:1.5-75; a step of dipping the ingredients in 50-90 wt% of alcohol for 6-10 hours; a step of extracting for 2-3 hours three times; and a step of concentrating by reduced pressure and freeze-drying at -25 deg. C.

Description

Mixture used to strengthen immunity

The present invention relates to the field of health foods and pharmaceuticals, and more particularly to a mixture used to increase immunity.

Ginseng is the dried root of ginseng, a plant of the family Arboraceae. In Part 1 of the People's Republic of China, Ginseng defines “cultivated as raw ginseng” and “wild thing as wild ginseng”. Ginseng is a perennial herb, 30-70cm high, raw root is flesh, and many side roots are extended below and stem is on the top, and the root is the same length or shorter than the stem. Wild ginseng grows in nature and has no artificial interference, so the shape is diverse and the shape is different. Some of them have a human "person" shape, some of which have a cylinder or spindle shape, and have many fine roots. Its distinctive features are clearly distinguished from cultivated ginseng. Wild ginseng has a long underground diameter outcrop, especially one to three times longer than the root of root, and only one tenth of the root diameter of cultivated ginseng. The discovery of wild ginseng has a history of 4,000 years from now, and the efficacy of ginseng in China's first pharmacological book, "Nong-Nong Herba", is known as "補 五臟, 安 精神, 定 魂魄, 止 驚悸, 除 邪氣, 明目, 開心 益.智, 久服 輕身 延年 (Ginseng is mainly to protect the five intestines, to stabilize the mind, stop the alert (驚悸), brighten the eyes, make the head wise and prolonged life if taken for a long time. " Wild ginseng is a rarer medicinal herb widely used in the treatment of various diseases.It is used for fatigue recovery, constitution improvement, replenishment of human body, improvement of circulation, cardiovascular function, cardiovascular circulation, myocardial nutrition, myocardial contractility, and myocarditis and coronary artery. Lowers the incidence of cardiovascular diseases such as sclerosis and myocardial infarction.

Chinese herbal medicine ginseng is a dry root of perennial herbaceous plants of Korean herbaceous perennial herbaceous ginseng, digested sugar ginseng, Cheondangsam, and various plants belonging to the family.潞 黨 蔘), Mundangsam (汶 黨 蔘), Bansamsam (대), ginseng (臺 蔘), Seoncho-geun (仙草 根), also called leaf leaf (葉子 菜). Dangsam is a plant belonging to about 40 species in the world, there are 39 species in China, medicinal 21 species, four varieties, Shanxi, Shaanxi, Gansu, Sichuan, Yunnan ), Guizhou, Hubei, Henan, Inner Mongolia, and Northeast. Dangsam is a traditional medicine commonly used in China. In ancient times, it was a product of sangsam in the equivalent of Shanxi. It has a taste and flatness.氣: to relieve spleen (를) and swelling down (비), dry nasal lungs (健脾 益肺: to strengthen the spleen (脾) and benefits the lungs) has the efficacy of Mainly non-inflammation weakening (기? 弱) and Giheyangyangheo (병: pathological condition in which both the functional decline due to eminence and the loss of tissue organs due to blood loss), the armed force (體 倦 無力: body This fatigue and powerless symptoms, heat exhaustion (內熱 消渴: symptoms of heat exhaustion (몸) symptoms in the body) to treat the symptoms. In modern medical research, Ginseng contains a variety of sugars, phenols, sterols, gasoline, Baikallein glycosides, saponins, and trace bioalkali to enhance immunity, dilate blood vessels, lower blood pressure, improve circulation, and improve hematopoietic function. In addition, chemotherapy and radiation therapy have been shown to have an increasing effect on the reduction of white blood cells. However, those who have a lot of heat (gas: stagnated and stagnant) and who have a lot of heat are forbidden to take it. It is not good to take sleeping.

Astragalus is a dry root of soybean and herbaceous plants, Mongolian Astragalus and Capsicum Astragalus. Astragalus is distributed in Inner Mongolia, Shanxi, Gamsu, Heilongjiang, etc., and is a national third-class protected plant. Astragalus is aesthetic sensation (味甘 性?: Sweet and mild temper) and bogus mark (補氣 固 表: symptom caused by lack of compactness due to lack of crisis), dihydrogen species (利 水 消腫: smooth urination to sink the swelling), takduk baechu (托 毒 排膿: using a drug that supplements the blood donated by regular support to push out the venom to discharge the pus inside), Efficacy as a muscle root (生 筋: makes muscle), and mainly deprivation of energy (氣? 乏力: a feeling of weakness and lack of strength throughout the body) and food defecation (食 少 便:: eating too little to stool This symptom is mild), mid-lowering (中 氣 下陷: a disease that usually occurs in the stomach), guttatalang (久瀉 脫肛: the condition that the anal is out due to long diarrhea), hemostatic bulge (便血 崩漏) : Abnormal blood bleeding from female genitals with bloody stool)表 虛 自汗: Lack of energy, the skin's defense function is not strong, sweating on its own, Gi Hui swelling (氣虛 水 증상: symptom of swollen body, swollen body) Boils do not heal), ulceral congestion (久? 不 斂: old and not sore open), haejugeuljeol (血虛 黄 hyeolhaeseo symptoms yellowing face), heat exhaustion (內熱 消渴: due to heat Small thirst), chronic nephritis proteinuria, diabetes and other conditions. Medicinal Astragalus has a history of more than 2000 years, and in modern medical research, Astragalus contains a variety of trace elements such as saponins, sucrose, polysaccharides, various amino acids, folic acid and selenium, zinc and copper to enhance gas immune function, It has been shown to have liver protection, diuresis, anti-aging, stimulation resistance, lowering blood pressure and extensive antibacterial activity. However, pathogenic humidity is due to stagnant flow of fluid due to gas loss due to surface fibrosis (Table: skin is fraudulent) and gaseous humidity tank. To further impede blood flow) Food stagnation (indigestion), early onggi (癰 疽 初起: strong morale during the process of scabies, weak swelling and coming out), or Yin and Yang are not balanced due to symptoms such as ulceration and ulcers (Yeumyang port, etc.). All patients who are unable to wander are prohibited from taking it.

Chunma is a dried tuber of egg and perennial herbaceous plant, Cheonma, which contains red antler, guinea pigs, shincho, poisonous leaves, It is also known as erypium, Jeongpungcho, Haengchocho, Dokyo, Jagocho, and weeping cow. Wild horses are distributed in Sichuan, Guizhou, Yunnan, Shaanxi, Hubei, Gansu, Anhui, Hanam, Gangseo, Hunan, Guangxi, Jilin, and Liaoning. The Yunnan communication is good, and after the move, it is collected from Cheongmyeong before the next year (good Dongma is good), washed immediately and dried at low temperature inside the pan. Cheonma is a famous Chinese herb and has been used as medicine for more than 2,000 years. It has aesthetic taste (sweet and flat nature), bohe (補) and plain food (平肝 熄風: soy sauce). To maintain the energy of the body to stop the abnormal wind (wind) made in the body), Geopungjeong (祛風 定 驚: to remove the wind (驚) to remove the 경) is effective, mainly dizziness, body Paralysis, children's race, epilepsy, hypertension, nervous breakdown, tetanus, windy rain ratio (風 寒濕 痺: Wind, cold, wet) caused by the overlap of the three stages (,), due to the ear Treat diarrhea and other conditions. In modern medical research, Cheonma has been shown to have significant therapeutic effects in vascular neurotic headaches and concussion sequelae, with high amounts of cheonmaso, vanillin, proteins, amino acids and trace elements.

The present invention first provides a mixture used to increase immunity, the mixture is obtained by the following method.

(1) Wild ginseng, Dangsam, Astragalus, and Cheonma are weighed, weighed and weighed from 100 to 200, and mixed. : We assume 1.5-75.

(2) The medicine powder mixture is soaked in alcohol at 50 to 90% by weight, which is 5 to 10 times the weight of the raw material, for 6 to 10 hours.

(3) Three times of rounds of extraction should be 2-3 hours each time.

(4) After the extraction was completed, the extracts were combined, concentrated under reduced pressure, and subjected to vacuum freeze drying at -25 ° C to obtain the desired mixture.

Here, the preferable weight ratios of wild ginseng, sugar ginseng, Astragalus and Cheonma are 1-4: 25-100: 25-100: 7.5-30.

More preferable weight ratio is 2: 50: 50: 15.

The wild ginseng, Dangsam, Astragalus, Cheonma can be obtained by purchasing in the market.

The present invention also provides a method for preparing the mixture and includes the following steps.

(1) Weigh wild ginseng, red ginseng, Astragalus and Cheonma, weigh each and weigh 100-200 throats and mix.

(2) The medicine powder mixture is soaked in alcohol at 50 to 90% by weight, which is 5 to 10 times the weight of the raw material, for 6 to 10 hours.

(3) Three times of rounds of extraction should be 2-3 hours each time.

(4) After the extraction was completed, the extracts were combined, concentrated under reduced pressure, and subjected to vacuum freeze drying at -25 ° C to obtain the desired mixture.

The resulting mixture can be prepared as a health food or drug in various formulations as an active ingredient and is used to enhance the immune system of the human body.

Here, the health food or medicine can be prepared as a dosage form includes capsules, tablets, granules, drinks, thickening agents, pills and the like formulation. Such formulations may be prepared by methods known to those skilled in the art.

Health foods or pharmaceuticals may be added with other medicinal supplements when formulated into preparations such as diluents, binders, flavoring agents, solubilizers, disintegrants, lubricants, colorants and the like.

The health food prepared using the mixture of the present invention delays aging, enhances memory, lowers blood pressure, grows consonants (신: 滋陰 補腎) and replenishes renal (補益). Efficacy), fatigue recovery, and immunity to increase the effect, wild ginseng, ginseng, Astragalus, Cheonma each alcohol extract is superior.

Example 1

According to the weight ratio of 0.2: 5: 5: 1.5, weighing 20g, 500g, 500g, and 150g of wild ginseng, sugar ginseng, astragalus, and cheonma, respectively, are powdered into a mixture of 100 to 200 medicinal powder, 5850g 90% alcohol After soaking in 6 hours, extract 3 times and make 2 hours each time. After the third round extraction, the extracts were combined, concentrated under reduced pressure, and the concentrate was subjected to vacuum freeze drying at -25 ° C to obtain the desired mixture.

Example 2

According to the weight ratio of 2: 50: 50: 15, weigh 100g, 2500g, 2500g, and 750g of wild ginseng, red ginseng, astragalus, and cheonma respectively on a scale, and then powder them with a mixture of 100 to 200 medicinal powders. After soaking in a container with a lid for 10 hours using a three-stage extraction to 3 times each time. After three rounds of extraction, the extracts are combined, concentrated under reduced pressure, and the concentrate is subjected to vacuum lyophilization at -25 ° C to obtain the desired mixture, thereby preparing a tablet according to a method known to those skilled in the art.

Example 3

According to the weight ratio of 6: 200: 150: 65, wild ginseng, red ginseng, astragalus, and cheonma were weighed, weighed 60g, 2000g, 1500g, and 650g, respectively, weighed on a scale, and then powdered into a mixture of 100 to 200 necks. After 8 hours soaking in% alcohol, extract 3 times. It is 2.5 hours each time. After the third round extraction, the extracts are combined and concentrated under reduced pressure, and the concentrate is subjected to vacuum freeze drying at -25 ° C to obtain a desired mixture. The granules are prepared according to a method known to those skilled in the art.

Example 4

According to the weight ratio of 3: 70: 60: 20, wild ginseng, red ginseng, astragalus and cheonma were weighed and weighed 30g, 700g, 600g and 200g, respectively, and powdered into 100 ~ 200 medicinal powder mixtures. 9180g 60% alcohol After soaking in for 7 hours, extract 3 times and make 2 hours each time. After the third round extraction, the extracts were combined, concentrated under reduced pressure, and the concentrate was subjected to vacuum freeze drying at -25 ° C to obtain the desired mixture.

Example 5

According to the weight ratio of 4: 100: 100: 30, wild ginseng, red ginseng, astragalus, and cheonma were weighed and weighed 40g, 1000g, 1000g, and 300g, respectively, and powdered into 100 ~ 200 medicinal powder mixtures. After soaking in for 9 hours, extract 3 times. It is 3 hours each time. After the third round extraction, the extracts were combined, concentrated under reduced pressure, and the concentrate was subjected to vacuum freeze drying at -25 ° C to obtain the desired mixture.

Example 6

According to the weight ratio of 8: 180: 170: 45, wild ginseng, red ginseng, astragalus, and cheonma were weighed and weighed 80g, 1800g, 1700g, and 450g, respectively, and powdered into 100 ~ 200 medicinal powder mixtures. After soaking in for 7 hours, extract 3 times and make 2.5 hours each time. After the third round extraction, the extracts were combined, concentrated under reduced pressure, and the concentrate was subjected to vacuum freeze drying at -25 ° C to obtain the desired mixture.

Example 7

Experimental method: 60 Kunming mice (half male and female, about 8 weeks old, about 25 ~ 30g) were randomly divided into 6 groups on average (see Table 1 for specific grouping method). Eight weeks after the injection, observe the effect on each group's immune system. Observational indicators are the spleen index and the thymus index, and the increase of both helps to increase immunity.

Military Organization Method: Control group 0.9% physiological saline of the same volume Of Mixture The mixture extracted in Example 2 4mgkg-1d-1 Wild Samgun Mixture extracted only wild ginseng by the method of Example 2 1mgkg-1d-1 Dangsam-gun Mixture extracted only ginseng according to the method of Example 2 4mgkg-1d-1 Hwanggi-gun Mixture extracted only Astragalus according to the method of Example 2 4mgkg-1d-1 Cheonma-gun Mixture extracted only cheonma according to the method of Example 2 2mgkg-1d-1

  Comparison of different bronchial indices of each group of mice Group Spleen Index (%) Thymus index (%) Weight （g） Control group 3.89 ± 0.091 2.57 ± 0.073 29.6 ± 0.41 Mixture 4.25 ± 0.078 ** 2.92 ± 0.068 ** 29.1 ± 0.38 Wild Samgun 4.12 ± 0.072 * 2.82 ± 0.064 * 29.5 ± 0.62 Dangsam-gun 4.04 ± 0.068 # 2.77 ± 0.076 # 30.1 ± 0.47 Hwanggi-gun 4.06 ± 0.064 # 2.74 ± 0.059 # 29.3 ± 0.53 Cheonma-gun 3.87 ± 0.083 ## 2.59 ± 0.065 ## 29.7 ± 0.38

Note: Spleen index = spleen weight / weight, thymus index = thymus weight / weight

* Indicates P <0.05, ** indicates P <0.01 when compared with the control group, # indicates P <0.05 and ## indicates P <0.01 when compared with the mixture group.

As can be seen from Table 2, the mixture group and wild ginseng group significantly increased the spleen index and thymus index compared to the control group, and the mixture group compared with the sugar sam group, Hwanggi group and cheonma group. There is a significant increase in the index value, and there is no significant difference between the mixture group and wild ginseng group, but the mixture group tends to be superior to the wild ginseng group. It shows that wild ginseng, Dangsam, Astragalus, Cheonma together, explains that there is a certain harmonic effect.

Claims (4)

(1) Wild ginseng, Dangsam, Astragalus and Cheonma are weighed and weighed into 100 to 200 pieces, mixed with 100 to 200 necks, where the weight ratio of wild ginseng, Dangsam, Astragalus and Cheonma is 0.2 to 10: 5 to 250: 5 to 250: 1.5-75,
(2) the medicine powder mixture is immersed in an alcohol of 50-90% weight ratio of 5 to 10 times the weight of the raw material for 6 to 10 hours,
(3) Extract the stream three times each time for 2-3 hours,
(4) After the extraction is completed, the extract is combined and concentrated under reduced pressure, and the mixture is used to increase the immunity, characterized in that prepared by the method of obtaining a desired mixture by vacuum freeze-drying to -25 ℃. The method of claim 1,
The wild ginseng, Dangsam, Astragalus, Cheonma weight ratio of 1 to 4:25 to 100: 25 to 100: 7.5 to 30, the mixture used to increase the immunity. The method of claim 1,
The weight ratio of the wild ginseng, sugar ginseng, Astragalus, Cheonma is 2: 50: 50: 15, the mixture used to enhance the immunity. (1) Wild ginseng, Dangsam, Astragalus and Cheonma are weighed and weighed into 100 to 200 pieces, mixed with 100 to 200 necks, where the weight ratio of wild ginseng, Dangsam, Astragalus and Cheonma is 0.2 to 10: 5 to 250: 5 to 250 ： 1.5 to 75,
(2) the medicine powder mixture is immersed in an alcohol of 50 to 90% weight ratio of 5 to 10 times the weight of the raw material for 6 to 10 hours,
(3) Extract 3 times of flows each time for 2-3 hours,
(4) a method for producing a mixture according to any one of claims 1 to 3, wherein the extraction is completed, the extracts are concentrated under reduced pressure, and the concentrate is vacuum-lyophilized to -25 ° C to obtain a mixture. .