KR20130005982A - Patch fabricating method - Google Patents

Abstract

PURPOSE: A method for manufacturing a patch is provided to minimize drug loss, to reduce manufacturing cost, and to enable users to easily handle drug disposal. CONSTITUTION: A method for manufacturing a patch comprises: a step of applying a drug on the surface of a drug film(112) which is unwound from a first unwinding roll(110) in one direction and forming a drug layer(116); a step of passing a laminated film with a release film(118) through upper and lower pressing rolls(122,124); a step of slitting the laminated film by a plurality of ring-shaped slitting blade in a longitudinal direction while passing the laminated film through upper and lower first cutting rolls; a step of winding the slit laminated film to a plurality of first winding rolls; a step of separating the release film of the slit film unwound from a winding roll; a step of passing the slit film through upper and lower second slitting rolls; a step of cutting the slit film by a plurality of linear slitting blades in a width direction; and a step of adhering the cut unit film onto an adhesion layer of a peripheral film.

Description

Patch Fabricating Method

The present invention relates to a method for manufacturing a patch, and more particularly, to a patch manufacturing method that can reduce the occurrence of scrap while minimizing the loss of the drug as an active substance, and can easily manage the disposal of expensive drugs.

In recent years, patches, which are drugs for the administration of drugs to the skin or from the mucous membranes, have been important as a means of administering drugs to patients. And make it possible to continuously administer a constant, controlled amount over a long period of time.

Patches that enable transdermal administration of drugs are generally classified into a matrix type in which the drug is dispersed in the adhesive layer and a reservoir type in which the drug storage layer is provided. The matrix patch is an impermeable additive which is applied with an adhesive on one side. It includes, wherein the pressure-sensitive adhesive includes a drug which is the active material for transdermal administration.

When the matrix patch is applied to the skin, the active substance is released from the pressure-sensitive adhesive and penetrates into the skin to obtain a therapeutic effect.

However, such a conventional patch has a problem of loading a sufficient amount of active material in the adhesive and a large drug loss in patch manufacture.

That is, Republic of Korea Patent Publication No. 10-1998-0050580 (published on September 15, 1999) discloses by applying a drug to the release film strip, and drying, the flexible film is continuously bonded with the dried release film strip, stretch film and release film Disclosed is a method of manufacturing a disc roll for preparing a drug transdermal administration material by winding a disc strip bonded to a strip.

In addition, Korean Patent Publication No. 10-1998-050583 (published on September 15, 1999) discloses a roll-shaped disc made of a release film, a drug and a stretch film release liner, and a roll-shaped adhesive tape made of a stretch film, a pressure-sensitive adhesive and a release liner. Disclosed is a device for preparing a transdermal drug delivery through a process of mutual processing and bonding to a predetermined shape while removing the release liner through a series of processes.

However, these conventional prior art allows the upper and lower left and right sides to allow sufficient space for each film layer in the process of uniformly cutting the peeling layer coated with the drug layer to a predetermined size using cutting means such as a cutting roller. Loss of drugs inevitably occurs because the area must be secured.

In addition, the scrap of the film layer including the residual drug layer after cutting is disposed of together with the drug, and if the drug to be disposed of as scrap is expensive, it not only acts as a cause of raising the manufacturing cost required to manufacture the patch, In the case of waste disposal regulations such as drugs, they have to be strictly managed, which added to the management cost.

Accordingly, the present invention is to solve the above problems, the object of which is to reduce the occurrence of scrap while minimizing the loss of the drug as the active material, to provide a patch manufacturing method that can easily perform the disposal of expensive drugs I would like to.

The present invention as a specific means for achieving the above object, the step of forming a drug layer by applying the drug on the surface of the drug film released in one direction from the first unrolling roll; Passing a laminated film having a release film released in one direction from a second unrolling roll on a surface of the drug layer between upper and lower pressure rolls; The lamination by a plurality of ring-shaped slitting blades provided on the outer circumferential surface of any one of the upper and lower first cutting rolls while passing the laminated film between the upper and lower first cutting rolls provided at the rear of the upper and lower pressing rolls. Cutting the film in the longitudinal direction; Winding each of the plurality of divided laminated films split in the longitudinal direction by the plurality of ring-shaped slitting blades onto a plurality of first winding rolls; After separating the release film of the divided film released from any one of the plurality of first winding rolls of the roll, and then passing the split film between the upper and lower second cutting rolls of any one of the upper and lower second cutting rolls Cutting the split film in the width direction by a plurality of straight slitting blades provided on an outer circumferential surface; And attaching the unit film cut in the width direction by the plurality of linear slitting blades to the adhesive layer of the peripheral film. It provides a patch manufacturing method comprising a.

Preferably, the drug layer is formed on the drug film and then the drug film is passed through a dryer to dry the drug layer before attaching the release film.

Preferably, the step of cutting the divided film in the width direction is to separate the release film laminated on the upper surface of the divided film before the split film enters between the upper and lower second cutting rolls, the separated release film It is wound up in a 2nd winding roll.

 Preferably, the step of cutting the divided film in the width direction is formed through the plurality of adsorption holes on the outer surface, adsorb the cut unit film to the second cutting roll connected to the first vacuum suction line, the adsorbed unit The film penetrates through the plurality of adsorption holes on the outer surface, and falls to be absorbed by the outer surface of the upper rotating hole connected to the second vacuum suction line.

More preferably, the adsorption force provided through the adsorption hole of the upper rotary roll connected to the second vacuum suction line is set relatively larger than the adsorption force provided through the adsorption hole of the lower second cutting roll connected to the first vacuum suction line. do.

Preferably, the step of attaching the unit film to the adhesive layer of the peripheral film, the peripheral film to remove the peripheral release film at the inlet side of the upper and lower rotary roll enters between the upper and lower rotary roll.

Preferably, the method further comprises the step of packaging a patch cut to a certain size the peripheral film to which the unit film is attached.

 More preferably, the unit film is bonded to the peripheral film bonded at regular intervals between the upper and lower packaging film and the roll gap of the upper and lower third cutting roll which rotates in engagement with each other, and the upper and lower A patch is manufactured by cutting a peripheral film having upper and lower packaging films laminated on upper and lower surfaces by a rectangular cutting groove size by a plurality of rectangular cutting grooves provided on an outer circumferential surface of any one of the three cutting rolls. .

More preferably, the scrap wound by the plurality of rectangular cutting grooves to form the rectangular perforated portion is wound on the fourth winding roll.

According to the present invention, a laminated film made of a drug film coated with a drug layer on the upper surface is cut in the longitudinal direction by a plurality of ring-shaped slitting blades provided on the outer circumferential surface of any one of the upper and lower first cutting rolls. A plurality of straight slitting blades are wound on the first winding roll with a split film and provided on the outer circumferential surface of any one of the upper and lower second cutting rolls to divide the split film released from any one of the plurality of first winding rolls. By cutting in the width direction by the widthwise direction, and the unit film cut in the width direction can be attached to the adhesive layer of the peripheral film to minimize the loss of the drug, the first cut and the second cut active material of the scrap containing the drug It is possible to reduce manufacturing costs, reduce manufacturing costs, increase yields, and easily manage waste disposal of drugs that are waste management targets. .

1 is a schematic diagram showing a process of winding the laminated film cut in the longitudinal direction in the patch manufacturing method according to an embodiment of the present invention.
Figure 2 is a schematic diagram showing a process of cutting and wrapping the laminated film divided in the width direction in the patch manufacturing method according to an embodiment of the present invention.
Figure 3 is a block diagram showing a process for cutting the laminated film in the longitudinal direction in another patch manufacturing method in an embodiment of the present invention.
Figure 4 is a block diagram showing a process of cutting the laminated film in the width direction in another patch manufacturing method in an embodiment of the present invention.
5 is a block diagram illustrating a process of perforating and packing a peripheral film with a unit film in another patch manufacturing method according to an embodiment of the present invention.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT Hereinafter, the present invention will be described in detail with reference to preferred embodiments and accompanying drawings, which will be easily understood by those skilled in the art. As those skilled in the art would realize, the described embodiments may be modified in various different ways, all without departing from the spirit or scope of the present invention.

In the patch manufacturing method according to a preferred embodiment of the present invention, as shown in Fig. 1 and 2, first to apply a drug to the surface of the drug film to form a drug layer, the drug film 112 is the first unrolling roll Drug film 112 that is released in one direction (right in the drawing) from 110, and the drug which is an active substance discharged by a predetermined amount from the applicator 114 provided at the exit side of the first unwinding roll 110 in one direction It is applied to the surface of the) to form a drug layer 116.

Then, the drug layer 116 applied to the surface of the drug film 112 is passed by the dryer 115 provided on the exit side of the applicator 114 by the heat source provided inside the dryer 115. To dry.

Subsequently, in order to cover the drug layer 116 applied on the surface of the drug film 112, the upper and lower presses of the release film 118 released in one direction from the second unwinding roll 120 rotate in engagement with each other. When the drug layer 116 is applied together with the drug film 112 coated on the surface between the rolls 122 and 124, the laminated film 1 having the drug layer 116 interposed between the drug film 112 and the release film 118 is provided. ) Is supplied to the upper and lower first cutting rolls 132 and 134 through the upper and lower pressure rolls 122 and 124.

At this time, the pressing roll of any one of the upper and lower pressing rolls 122 and 124 is preferably provided to be able to adjust the upper and lower positions on the roll support on which the left and right ends of the pressing roll are assembled so as to adjust the pressing force by adjusting the roll gap.

A pinch roll 126 is provided between the second unrolling roll 120 and the upper press roll 122 to adjust the tension of the release film 118.

In addition, the step of cutting the laminated film (1) in the longitudinal direction, as shown in Figure 1 and 3, the upper, lower pressing rolls 122, 124 provided in the rear, the lower first cutting rolls (132, 134) When the laminated film 1 passes between the roll gaps of the sheet), the plurality of ring-shaped slitting blades 133 are provided on the outer circumferential surface of any one of the upper and lower first cutting rolls 132 and 134. Thus, the laminated film 1 is continuously cut in the longitudinal direction so as to be converted into a plurality of divided laminated films 2 having a predetermined width.

Here, the upper and lower first cutting rolls 132 and 134 adjust the roll gap of any one of the upper and lower first cutting rolls as in the upper and lower pressing rolls 122 and 124 to adjust the film cutting depth. It is preferable that the upper and lower positions of the first and second cutting rolls can be adjusted to the roll support.

And, the ring-shaped slitting blade 133 is shown and described as being provided in the circumferential direction on the outer circumferential surface of the upper first cutting roll 132, but is not limited to this, the lower first cutting roll 134 or the upper, lower It may be provided in one cutting roll (132, 134).

After being cut into a plurality of divided laminated films 2 while passing through the roll gaps of the upper and lower first cutting rolls 132 and 134, the divided films are guided to the plurality of first winding rolls 136 and the first winding rolls 136. ) Is wound in the form of a roll on the outer peripheral surface of each.

On the other hand, the step of cutting the split film 2 in the width direction first proceeds by unwinding the split film 2 wound on any one of the plurality of first winding rolls 136 winding roll 136 in one direction .

Then, the release film 118 laminated on the upper surface of the split film 2 released from the first winding roll 136 is separated from the front, which is the mouth side of the upper and lower second cutting rolls 142 and 144, and is separated. The release film 118 is wound around the second winding roll 146.

Here, the release film 118 is separated from the drug layer 116 by the release film separating means 148 provided on the front side of the second cutting roll 141.

When the release film 118 is separated into the roll gap between the upper and lower second cutting rolls 142 and 144, the drug layer 116 and the drug film 112 stacked on the drug film 112 enter and pass. The cutting film 2 is cut in the width direction by a plurality of straight slitting blades 145 installed on the outer circumferential surface of any one of the lower second cutting rolls 142 and 144 in the direction perpendicular to the film advancing direction. The unit film is prepared.

At this time, the second cutting roll 144 on which the linear slitting blade 145 is mounted is formed to penetrate through a plurality of adsorption holes 144a on the outer surface to adsorb the cut unit film, and the adsorption holes 144a. It is connected to the first vacuum suction line 149 to provide a suction force through).

Subsequently, as shown in FIGS. 2 and 4, the unit film 3 cut in the width direction by the plurality of linear slitting blades 145 is attached to the adhesive layer of the peripheral film 155. do.

The unit film 3 is dropped to the upper surface of the upper rotary roll 152 of the upper and lower rotary rolls 152 and 154 to rotate in the interlocking direction, the upper rotary roll 152 in which the unit film 3 falls The second vacuum suction line 159 and the inner space of the body is connected, and the peripheral film 155 by the vacuum suction force of the unit film (3) dropped by forming a plurality of adsorption holes (152a) through the outer peripheral surface It can be transported between the roll gap entered.

Here, the suction force provided through the adsorption hole 152a of the upper rotary roll 152 connected to the second vacuum suction line 159 is the lower second cutting roll 144 connected to the first vacuum suction line 149. Since the relatively larger than the adsorption force provided through the adsorption holes 144a, the unit film cut in the width direction from the lower second cutting roll 144 to the upper rotary roll 152 can be smoothly transferred.

The lower second cutting roll 144 and the upper rotary roll 152 are rotated in opposite directions without being engaged with each other, and are provided with different outer diameters and rotated at different rotational speeds so as to rotate the lower second cutting roll 144. The unit film separated from the outer circumferential surface of the roll 144 is placed at a predetermined interval on the adhesive layer of the peripheral film with the drug layer as the upper layer and the drug film as the lower layer.

In addition, the peripheral film 155 is released in one direction from the third unrolling roll 151, the release film 156 laminated on the unwinding peripheral film 155 is between the upper and lower rotary rolls (152, 154) Before entering, it is separated from the adhesive layer by the release film separating means 157 provided on the front side of the lower rotating hole 154, and then wound in a roll form by the third winding roll 158 to be post-processed.

 Successively, the upper and lower packaging films (161, 163) are laminated on the upper and lower portions of the peripheral film 155 attached to the center of the width of the unit film (3) and cut to a predetermined size to patch the packaging film laminated It will be prepared.

That is, as shown in Figures 2 and 5, the unit film 3 is rotated in the direction in which the peripheral film 155 disposed at regular intervals at the center of the width and interlocking with the upper and lower packaging films. When passing between the roll gaps of the upper and lower third cutting rolls (162 and 164), a plurality of rectangular cutting grooves (162a) provided on the outer circumferential surface of any one of the upper and lower third cutting rolls (162 and 134). The upper and lower packaging films 161 and 163 are laminated on the upper and lower surfaces by the peripheral film 155 to be cut into rectangular cut grooves, and then drop the patch having the upper and lower films attached thereto.

In addition, the scrap 169 cut by the plurality of rectangular cutting grooves 162a to form a rectangular perforated portion is wound on the fourth winding roll 168 in the form of a roll and then processed.

In addition, the upper and lower packaging films 161 and 163 are released in one direction from the upper and lower unrolling rolls 165 and 166 to enter between upper and lower third cutting rolls 162 and 164 into which the peripheral film 155 enters.

While the present invention has been described in connection with what is presently considered to be practical exemplary embodiments, it is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, Do.

110: first unrolling roll 112: drug film
114: applicator 115: dryer
116: drug layer 118: release film
120: second unrolling roll 122,124: upper, lower pressure roll
132,134: upper and lower first cutting roll 133: ring-type slitting blade
136: first winding roll 142,144: upper and lower second cutting roll
145: straight slitting blade 152,154: upper and lower rotating holes
155: peripheral film 156: peripheral release film
161,163: upper and lower packaging film 162,164: upper and lower third cutting roll

Claims (9)

Forming a drug layer by applying a drug to the surface of the drug film that is released in one direction from the first unrolling roll;
Passing a laminated film having a release film released in one direction from a second unrolling roll on a surface of the drug layer between upper and lower pressure rolls;
The lamination by a plurality of ring-shaped slitting blades provided on the outer circumferential surface of any one of the upper and lower first cutting rolls while passing the laminated film between the upper and lower first cutting rolls provided at the rear of the upper and lower pressing rolls. Cutting the film in the longitudinal direction;
Winding each of the plurality of divided laminated films split in the longitudinal direction by the plurality of ring-shaped slitting blades onto a plurality of first winding rolls;
After separating the release film of the divided film to be released from any one of the plurality of first winding rolls of the plurality of winding rolls, the upper and lower second cutting rolls while passing the split film between any one of the upper and lower second cutting rolls Cutting the split film in the width direction by a plurality of straight slitting blades provided on an outer circumferential surface; And
Attaching the unit film cut in the width direction by the plurality of linear slitting blades to the adhesive layer of the peripheral film; Patch manufacturing method comprising a. The method of claim 1,
Forming the drug layer on the drug film and then attaching the drug film through the dryer before attaching the release film, the patch manufacturing method characterized in that for drying the drug layer. The method of claim 1,
The cutting of the divided film in the width direction may include separating the release film stacked on the upper surface of the divided film before the split film enters between the upper and lower second cutting rolls, and winding the separated release film into a second winding. The patch manufacturing method characterized by winding up on a roll. The method of claim 1,
Cutting the split film in the width direction may include penetrating a plurality of adsorption holes on the outer surface, adsorbing the cut unit film to a second cutting roll connected to the first vacuum suction line, and the adsorbed unit film is external Forming a plurality of adsorption holes through the surface, the patch manufacturing method characterized in that the drop so as to be adsorbed on the outer surface of the upper rotary hole connected to the second vacuum suction line. 5. The method of claim 4,
The adsorption force provided through the adsorption hole of the upper rotary roll connected to the second vacuum suction line is set to be relatively greater than the adsorption force provided through the adsorption hole of the lower second cutting roll connected to the first vacuum suction line. Patch manufacturing method. The method of claim 1,
The step of attaching the unit film to the adhesive layer of the peripheral film is a patch manufacturing method characterized in that the peripheral film is removed from the upper and lower rotary rolls, the peripheral film is removed between the upper and lower rotary rolls. The method of claim 1,
The patch manufacturing method characterized in that it further comprises the step of packaging a patch cut to a certain size peripheral film attached to the unit film. The method of claim 7, wherein
Peripheral film bonded to the unit film at a predetermined interval is supplied between the upper and lower packaging film between the roll gap of the upper and lower third cutting roll rotated in engagement with each other, the upper and lower of the third cutting roll The method of manufacturing a patch, characterized in that for cutting the peripheral film of the upper and lower packaging film laminated on the upper and lower surfaces by a plurality of rectangular cutting grooves provided on the outer peripheral surface of any one of the third cutting roll to the size of the rectangular cutting groove. 9. The method of claim 8,
The method for manufacturing a patch, characterized in that the scrap is cut by the plurality of rectangular cutting grooves to form a rectangular perforated portion on a fourth winding roll.

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