KR100262698B1 - Method of manufacturing medical patch for percutaneous administration and apparatus for making the same - Google Patents

Abstract

The present invention relates to a method and apparatus for producing a drug transdermal patch, more specifically, a release film (1) + drug (3) + elastic film (polyurethane) (4) Release the release roll (release liner) or the release film (1) + drug (3) + elastic film (polyurethane) (4) the original roll through a series of processes The film 1, the drug layer 3, and the stretchable film 4 are cut, half-die cut, and die-cut into a predetermined shape, thereby providing excellent elasticity, antifouling property, sustainability of drug, and warning of adhesion. The present invention relates to a method for producing a drug transdermal agent of a predetermined shape and an apparatus for manufacturing the same. Apparatus for producing a drug transdermal drug according to the present invention is a device for manufacturing a drug transdermal drug disclosed in the applicant's first domestic patent application No. 96-69415 and the second stretchable film layer (7) + adhesive (adopted in the same method) 6) The process of removing the release liner 5 'of the adhesive tape roll by omitting the adhesive tape roll 20 composed of the release liner 5', the temporary and main pressure of the original roll of the adhesive tape roll 20 The entire process is greatly shortened by eliminating the attaching process, the half die cutting of the second stretchable film of the adhesive tape roll, and the remaining scrap removing process formed during the half die cutting process of the second stretchable film of the adhesive tape roll. There is an advantage that the configuration of the manufacturing apparatus can be greatly simplified and there is an advantage that can reduce the production cost of the transdermal drug delivery.

Description

Method for manufacturing drug transdermal agent and apparatus therefor

The present invention relates to an apparatus for preparing a drug transdermal drug, and specifically, a predetermined portion of the release film is unwound while unrolling a disc in roll form consisting of a release film + drug + stretchable film or a release film + drug + stretchable film + release liner. For example, the center part is cut along the longitudinal direction, and the drug + stretchable film laminated thereon is half-cut to a predetermined shape and punched out, and the punched drug + stretchable film is concentrically contained. The present invention relates to a method for manufacturing a drug transdermal agent by die-cutting a release film in the shape of and a manufacturing apparatus thereof.

Analgesic and anti-inflammatory drug pyroxicam effective for acute pain and acute gout of rheumatoid arthritis, osteoarthritis, musculoskeletal disorders has a strong therapeutic effect upon oral administration, but gastrointestinal disorders and digestive effects following oral administration It is known to cause side effects such as ulcers.

In order to solve this problem, the inventors of the Korean Patent Application No. 93-32006 dated December 31, 1993, the substrate layer consisting of an active ingredient, a tacky polymer material and an absorbent protection agent containing pyroxicam and a non-permeable affixed thereon There has been disclosed a transdermal administration system consisting of a release film attached to the back layer and under the substrate layer so as to be peeled off. The invention of this patent application No. 93-32006 mainly relates to the composition of the drug absorbent and absorption accelerator in the substrate layer. The focus is on the invention.

On the other hand, the drug transdermal administration system is primarily of the composition of the substrate layer containing the drug, but also physical properties of the product as important as the composition of the substrate layer to obtain the desired effect when the product is attached to the affected area.

That is, it should be firmly attached to the joints of knees and elbows while maintaining elasticity, not to fall even during bathing or showering, to prevent contamination from the outside, and to have no external loss of medicinal components. In addition, it is preferable that the thin and small shape is selectively round or oval as possible to selectively attach to each affected area. Conventionally, a product having a structure in which a drug is laminated on a nonwoven fabric or a fabric cannot satisfy the above requirement.

An example of a transdermal administration agent capable of satisfactorily satisfying the above physical requirements while considering the composition of a substrate layer containing a drug to be used is an apparatus disclosed in Korean Patent Application No. 69415 dated December 21, 1996 of the present applicant. Some have been manufactured. FIG. 9A shows a plane of the transdermal agent prepared by the apparatus disclosed in the above-mentioned Korean Patent Application No. 96-69415, and FIG. 9B shows a cross section taken along the line a-a of FIG. 9A. In FIG. 9A and FIG. 9B, reference numeral 1 denotes a release material that is peeled off when the product P is attached to the affected part, and a film coated with silicon on a resin such as paper or polyethylene terephthalate (PET) (hereinafter referred to as a release film). ), And a first stretchable film layer 4 made of a material such as drug layer 3, PU (polyurethane), polyethylene terephthalate (PET) or styrene iso-styrene (SIS), is laminated thereon, and an adhesive layer ( 6) and a secondary stretchable film layer 7 made of a material such as PU (polyurethane), PET (polyethylene terephthalate) or SIS (styrene iso-styrene) are sequentially stacked.

The drug transdermal drug having the above structure is a release film (1) + drug layer (3) + primary stretchable film layer (4) + disclosed in another Korean patent application No. 69412 dated December 21, 1996 of the present applicant The secondary stretchable film layer 7 + adhesive 6 + release having a cross section separately prepared by a disc roll 10 consisting of a release liner 5 (see FIGS. 10A and 10B) and another process. A half die cut method of partial incision, mutual adhesion, punching, die cut, and adsorption is performed to remove the release liners through a series of processes. It is made through a continuous process such as discharge, the specific manufacturing process is disclosed in detail in the applicant's domestic patent application No. 96-69415.

By the way, the cross-sectional structure of the drug transdermal drug according to the domestic patent application No. 96-69415, as described above (see Fig. 9b), the release film (1), drug layer (3), primary stretch film layer (4) ), The pressure-sensitive adhesive layer 6 and the secondary stretchable film layer 7 are laminated in this order, and in this structure, the pressure-sensitive adhesive layer 6 is substantially the same material as the primary stretchable film layer 4 and 2. In addition to mutually bonding the primary elastic film layer (7) and the drug transdermal agent when the patch is applied to the skin is applied to a slightly larger area than the drug layer to have an adhesive force to the skin. The two layers of stretchable film layers 4 and 7 were found to be capable of meeting the above-mentioned physical requirements of the drug transdermal drug even when composed of a single stretchable film layer. For example, the pressure-sensitive adhesive layer (6) and the second stretchable film layer 7 are omitted, i.e., the second stretchable film layer 7 + adhesive (6) employed in the drug transdermal drug production process disclosed in the above-mentioned patent application 96-69415. When omission of the adhesive tape roll consisting of the + release liner, the manufacturing process of the drug transdermal administration agent can be greatly shortened, the manufacturing apparatus can be simplified, and the production cost can be greatly reduced. In this case, the externally exposed film layer 7 in the transdermal agent disclosed in Korean Patent Application No. 96-69415 is replaced with the stretchable film layer 4 exposed to the outside in the present invention, and drug transdermal administration. The adhesion to the skin when using the agent is achieved by the adhesive contained in the drug layer.

The present invention is a method and apparatus for manufacturing a drug transdermal drug disclosed in the applicant's domestic patent application No. 96-69415, only one stretchable film (4) instead of two layers of stretchable film layer (4) (7) An object of the present invention is to provide a method for producing a transdermal drug and a device for producing the same.

Still another object of the present invention is a pressure-sensitive adhesive consisting of a secondary stretchable film layer (7) + adhesive (6) + release liner in the method and manufacturing apparatus for drug transdermal administration disclosed in the applicant's domestic patent application No. 96-69415 By eliminating the tape roll, the manufacturing process of the drug transdermal drug administration can be greatly shortened, and the manufacturing apparatus can be simplified to increase the productivity and to lower the production cost of the product.

Still other objects and effects of the present invention will be apparent from the configurations and effects of the present invention described below.

1a and 1b are respectively a plan view and a-a cross-sectional view of a drug transdermal agent prepared by the device according to the present invention.

Figures 2a and 2b are respectively a perspective view and a cross-sectional view taken along line b-b of a disc roll used as a raw material when preparing the drug transdermal drug administration by the device according to the present invention.

Figure 3 is a view schematically showing the entire manufacturing process of the drug transdermal administration according to the present invention.

Figures 4a to 4h is a planar and longitudinal cross-sectional view so as to know the planar shape of the strip or residual scrap and its lamination structure in each step in the overall manufacturing process of the drug transdermal administration according to the present invention shown in Figure 3 Figure is a diagram.

Figure 5 is a front view showing the whole of the device for producing a drug transdermal administration.

Figure 6 is an enlarged view of the main portion of the manufacturing apparatus of the drug transdermal drug administration according to the present invention (VI enlarged view of Figure 5).

FIG. 7 is a perspective view of the inner portion of FIG. 6. FIG.

8 is a cross-sectional view of the main die roller and the vacuum pad roller.

9A and 9B are a plan view and a cross-sectional view along a-a line of the drug transdermal administration agent manufactured by the apparatus disclosed in Korean Patent Application No. 96-69415 of the applicant, respectively.

10A and 10B are a perspective view and a cross-sectional view, respectively, of a disc roll for preparing a transdermal drug administration prepared by the apparatus disclosed in the applicant's first domestic patent application No. 96-69412.

Explanation of reference numerals for main parts

1: Release film 2: Incision

3: drug layer 4: (primary) stretchable film layer

5,: release liner layer 6: adhesive layer

7: secondary stretchable film layer 10: disc roll

12: original roll unwinding roller (first unwinding roller)

14, 14 ': Dividing die roller (first half die cutting roller)

16: Remaining scrap of drug layer + primary stretch film layer (second half die cutting remaining scrap)

18: first workpiece 30: second workpiece

40, 41: delivery roller 44: release film allocation device

50: main unit 52: second half die cutting roller

52A: Large diameter 52B: Small diameter

59: die cutting roller 60: main die roller

62: conveyor 66: remaining scrap winding roller

76: scrap temporary winding roller 86: residual film scrap

90: vacuum pad roller 93: vacuum suction hole

100: frame TC1, TC2: tension controller

P: Products

Hereinafter will be described in detail with reference to the accompanying drawings, an apparatus for preparing a drug transdermal administration according to the present invention.

Figure 3 is a schematic view of the entire manufacturing process of the product using the drug transdermal drug production device according to the present invention, Figures 4a to 4h are strips or residual at each step in the product manufacturing process according to the present invention shown in FIG. The plane and cross section are shown in order to know the shape of the plane and cross section of the scrap and its lamination structure. Referring to these drawings, the overall manufacturing process of the product using the apparatus according to the present invention will be described as follows. In FIG. 3, the X axis represents the progress of the process, and the a, b, c, d, e, f, g and h of FIG. 3 are respectively 4A, 4B, 4C, 4D, 4E, 4F, and FIG. 4G and FIG. 4H.

(First step)

Release roll (10) or release film (1) + chemical layer (3) + stretchable film layer (4) of release film (1) + chemical layer (3) + stretchable film layer (4) + release liner layer (5) ) And unwinding the disc roll 10 made of) by the first unwinding roller 12 (see FIGS. 3 and 4A and 4B).

In the above step, when the original roll 10 is composed of the release film (1) + chemical layer (3) + stretchable film layer (4) + release liner layer (for example, the applicant's domestic patent application No. In the case of the disc roll disclosed in 96-69412), when the disc roll is continuously unwound, the release liner layer 5 is peeled off from the release film and wound on a separate winding roller 64, and the disc roll is a release film. (1) + chemical layer (3) + stretch film layer (4) (e.g., another patent application filed by the applicant as the same as the present application) In the case of the disc roll disclosed in the production method and the manufacturing method thereof), there is no release liner to be removed, so the disc roll is unwound continuously.

(Second stage)

Only the release film 1 is half die cut by passing the unrolled, unreleased, roll of the release liner between a pair of half die cutting rollers 14 and 14 '. ) To form an incision 2 in at least one or more places continuously in the longitudinal direction thereof (see FIGS. 3 and 4C).

The product produced by the device according to the present invention is a release film (1) and the drug layer (3) or the stretchable film layer (4) is only a few tens of micrometers in thickness and the overall laminated thickness is very thin, the release film (1) If a proper incision is not formed in the), it becomes very inconvenient when the release film 1 is peeled off in order to attach the product P to the affected part. Therefore, the second step is a step for forming such an incision 2 in the release film, leaving the drug layer and the stretched film layer 4 stacked thereon, leaving only the release film 1 in its longitudinal direction. Therefore, the incision is continuously made by a half die cut method.

(Third step)

The drug layer 3 and the stretchable film layer 4 laminated on the upper surface of the release film while adsorbing and moving the release film 1 of the disc roll passed through the second step on the surface of the main die roller on the main die roller 60. In order to remove the residue scrap 16 of the drug layer and the stretchable film layer from the release film by half-cutting (second half-cutting) at a time in a predetermined shape, such as an ellipse or a circle, and remaining on the release film. Winding the residue scrap into the roller 66 (see FIGS. 3 and 4D, 4E).

As a result of the third step, an elliptic or circular drug layer and a stretchable film layer 4 of the same size and same shape superimposed thereon are laminated on the release film strip having the incision 2 formed through the second step. The formed first workpiece 18 is adsorbed on the surface of the main die roller 60 of the vacuum adsorption drum method and starts to move along its circumferential surface.

(Fourth step)

The drug layer 3 when the first workpiece 18 formed by the third step process is adsorbed on the surface of the main die roller 60 of the vacuum adsorption drum method and moved by a predetermined length along the circumferential surface thereof. And a shape of the drug layer and the stretchable film layer while the release film 1 is concentrically formed in a predetermined shape, for example, the drug layer and the stretchable film layer at a position where the stretchable film layer 4 remains. Die cutting into a slightly larger ellipse or round or square shape, and forming a second workpiece (finished product before packaging) 30 by winding and removing the remaining scrap 26 of the resulting release film (FIG. 3 and 4f, 4g).

According to the fourth step, an ellipse, a circular or square shaped release film 1 + an ellipse or a circular drug layer 3 + an ellipse or a circular shape are formed on the main die roller with an incision 2 formed at the center thereof. Each finished product P of the drug transdermal agent, which is laminated with the stretchable film layer 4, is adsorbed on the main die roller and transported continuously according to the rotation of the main die roller. The second workpiece 30 manufactured by the above step forms a finished product (P) before packaging.

(Step 5)

Adsorbing the second workpiece from the surface of the main die roller (60) by a vacuum pad roller (90) in which vacuum suction pads are formed at equal intervals in the circumferential direction and moving them onto the conveyor (62).

The entire manufacturing process of the drug transdermal administration product according to the present invention comprises the above steps.

Figure 5 is a front view showing the overall configuration of the apparatus for producing a drug transdermal drug administration according to the present invention. Referring to the configuration of each of the devices shown in Figure 5 in accordance with the above-described manufacturing process sequence as follows.

Reference numeral 100 denotes a frame of the apparatus for manufacturing a drug transdermal drug administration according to the present invention, which is movable with a jack and is preferably made of SS material.

Reference numeral 12 denotes a disc unwinding shaft for unwinding the disc roll 10, which is biaxially fixed and arranged in two rows at the top and bottom ends. The two-row arrangement configuration is for releasing the preliminary disc roll wound on the other without stopping the operation of the disc when the disc roll 10 wound on any one unwinding shaft is released. This is the configuration for improving productivity. Although not shown, the unwinding shaft 12 is provided with an axial fine adjustment device, a manual brake, a disc reduction alarm, and a cutting detection device.

Reference numerals 40 and 40 'denote a pair of disc roll feeding rollers to always deliver a fixed quantity by decelerating the speed of the feeding roller by the displacement amount of the dancer roller 42 with a balancer. The dancer roller 42 has a constant weight by the balance weight, and always sends the disc strip toward the die roller 60 at a constant tension regardless of the disc shaft diameter.

Reference numeral 44 denotes a drainage device for continuously cutting only the release film 1 of the disc roll 10 into a predetermined shape, for example, a wave. 14 ') (first half die cutting roller), the release film 1 is half die cut (first half die cut) in a wave form continuously in the longitudinal direction.

Reference numeral 50 denotes a main unit of the apparatus for manufacturing a product according to the present invention on the release film 1 while the disc roll is sucked and transported on the surface of the main die roller 60 by the unit. The drug layer 3 and the stretchable film layer 4 are successively half die cut (second half die cut) into an ellipse or a circular shape, and the half die cut drug layer and the stretchable film layer remain at the positions. The second processed body is formed by punching, ie die cutting, into a rectangle containing a predetermined shape, for example, the drug layer (elastic film layer) concentrically with the release film. And the remaining release film scrap produced by the die cutting by winding up and removing the finished product, and then vacuum-adsorbing the finished product from the surface of the main die roller 60 by the vacuum pad roller 90 to convey the conveyor 62. Perform a series of processes such as discharging up.

In the present invention, the term "half die cutting" means that the cutting of the die having a laminated structure of two or more layers is performed only with a specific shape such as kiss cutting or the like in a predetermined shape (ie, partial cutting). The half die cutting roller refers to a roller device in which a kiss cutting blade is formed on a circumferential surface in order to perform such half die cutting. Die cutting means cutting or punching the entire layer of the strip into a predetermined shape. A die cutting roller uses a roller device having a die cutting blade formed on a circumferential surface to perform such die cutting. it means.

A second half die cutting roller 52 for half die cutting the drug layer 3 and the stretchable film layer 4 of the disc roll into an ellipse or a circular shape, and a die cutting roller 59 for punching the entire (release film). In each circumferential surface of), a plurality of elliptical, circular or square shaped kiss cutting or die cutting blades are placed at equal intervals in the circumferential direction, and a specific example of this configuration is the second half die cutting roller 52. A well-illustrated perspective view of FIG. 7 is shown.

On the other hand, a plurality of vacuum suction holes 93 are formed on the surface of the main die roller 60 to vacuum-release the release film 1 of the disc roll on the surface during the second half die cutting and die cutting. Transfer it.

As shown in FIG. 8, the vacuum pad roller 90 for adsorbing and discharging the product P from the surface of the main die roller 60 has a die cut product as a roller having a rubber sucker attached to its outer circumferential surface. Adsorbed from the surface of the die roller 60 is transferred to the conveyor (62).

When the disc roll 10 described above is composed of only the release film 1 + the drug layer 3 + the stretchable film layer 4, for example, it is the disc roll disclosed in another patent application filed by the applicant as the same as the present application. In this case, the release liner winding shaft shown at 64 in Fig. 5 is an unnecessary element because the release liner has been removed in advance, but the original roll is a release film (1) + chemical layer (3) + elastic film layer (4) + In the case of the release liner 5, for example, a disc roll according to the applicant's prior patent application 96-69412, the release liner 5 should be removed when the disc roll is unwound. 64) is essential. The release liner winding shaft 64 is a single-axis fixed type with one end fixed pivotably and the other end free. The release liner is suitably powered by the powder clutch and the tension tension controller (TC1) regardless of its winding diameter. This winding shaft 64 is equipped with an alarm device for informing the state of the full winding when winding up.

In FIG. 5, reference numeral 66 denotes a single axis fixed and powder clutch, similar to the release liner layer winding shaft 64 of the disc roll, as a residual shaft 16 winding shaft of the drug layer and the stretchable film layer generated during the second half die cutting. With a tension controller TC2, the coil is wound with a constant force regardless of the diameter of the scrap.

FIG. 6 is an enlarged view of part VI of FIG. 5 showing the main unit 50 according to the present invention, and FIG. 7 shows the configuration of the second half die cutting roller 52 and the die cutting roller 59. FIG. (These are the same structures) is a view showing a perspective view of the second half die cutting roller 52 (the lower part of FIG. 6) by way of example, Figure 8 is the main die roller 60 and the vacuum pad roller 90 ) Is a cross-sectional view showing a vent hole 61 and a vacuum suction hole 93 for vacuum suction.

As can be seen from these figures, the second half die cutting roller 52 has a large diameter portion 52a formed at both ends, a small diameter portion 52b formed between the large diameter portion, and the table on the outer circumferential surface of the small diameter portion. A plurality of elliptical or circular or square kiss cutting blades 52c, which are placed at a height slightly lower than the step height of the neck portion and the small diameter portion, are provided, and the surface of the main die roller 60 has a plurality of vacuum suction holes. (93) is formed so that the disk strip is adsorbed on the surface of the main die roller 60 during the second half die cutting process and the die cutting process by the die cutting roller 59 and transferred by the rotation of the main die roller. Each strip die cutting roller and die cutting roller are sequentially passed through each space formed by the step between the large diameter portion and the small diameter portion of the above-mentioned half die cutting roller and die cutting roller. By a blade (not shown) ipseol each small diameter is cut half-die cutting and die.

Next, the whole operation process of the manufacturing apparatus of the drug transdermal administration agent which was demonstrated above is demonstrated.

The disc roll 10 from which the release liner 5 is removed, which is released from the first winding roller 12 while the feeding speed is constantly adjusted by the pair of feeding rollers 40 and 41, has a pair of cutting dies. Only the release film 1 is continuously cut in the longitudinal direction while passing through the rollers 14 and 14 '(first half die cutting).

Subsequently, the first half-die cut disc rolls are adsorbed on the surface of the main die roller 60 and moved along the surface thereof, and a plurality of ellipses or circles placed at circumferential equal intervals of the second half die-cut roller 52 The drug cutting layer (3c) and the stretchable film layer (4) is half-die-cut by the kiss cutting blade (52c) of the first workpiece 18, and the resulting drug layer and scrap of the stretchable film layer ( 16) is removed from the original roll by being wound by the winding roller 66.

The first workpiece 18 adsorbed on the surface of the main die roller 60 and moved a little further along the surface thereof is circumferentially spaced on the circumferential surface having the same structure as the second half die cutting roller 52 described above. The entire strip is die cut by a die cutting roller 59 formed by inserting a plurality of rectangular die cutting blades, thereby completing a product as shown in FIG. 1A (FIG. 4H), each of which is circumferentially equally spaced. By the suction action of the vacuum pad roller 90 in which the rubber sucker is formed, the rubber sucker is sucked from the surface of the main die roller and transferred onto the conveyor 62. Products transferred onto the conveyor are shipped after inspection and packaging.

The drug transdermal administration prepared by the manufacturing process and apparatus according to the present invention as described in detail above is sufficiently equipped with the above-described physical requirements as a product, while maintaining the elasticity in the joints such as knees and elbows It is firmly attached for a long time (at least 48 hours), not only falls in the bath or shower, but also prevents contamination from the outside and there is no external loss of medicinal ingredients.

Apparatus and method for manufacturing a drug transdermal drug according to the present invention is a second stretchable film layer (7) adopted in the drug transdermal drug preparation device and the method of manufacturing disclosed in the applicant's first domestic patent application No. 96-69415 ) Omitting the adhesive tape roll consisting of the adhesive (6) and the release liner, thus removing the release liner of the adhesive tape roll, temporary and main pressure applying process to the original roll of the adhesive tape roll, and adhesive tape roll Half-cutting process of the second stretchable film 7 and the process of removing the remaining scrap formed during the half-diecutting process of the second stretchable film of the adhesive tape roll are omitted, thereby greatly reducing the overall process. There is an advantage that the configuration of the manufacturing apparatus can be greatly simplified. The present invention can significantly reduce the production cost of the product (P) in connection with this advantage it is possible to supply a superior product to the consumer at a lower price.

Claims (5)

1. Release roll (10) or release film (1) + chemical layer (3) + stretchable film layer of release film (1) + chemical layer (3) + stretchable film layer (4) + release liner layer (5) A first step of continuously unwinding the disc roll (10) made of (4) by the first unwinding roller (12); By passing the unwound disc roll between a pair of half die cut rollers 14 and 14 ', only the release film 1 is half die cut (first half die cutting) and then in the longitudinal direction thereof. A second step of continuously forming the incision 2 at at least one location; Simultaneously half die cutting (second half die cutting) the drug layer 3 and the stretchable film layer 4 stacked on the release film 1 of the disc roll in a predetermined shape, and the drug layer and the stretchable film produced at this time. Winding the scrap to remove residual scrap (16) of the layer; The strip laminated with the release film (1) + predetermined drug layer (3) + predetermined stretchable film layer (4) formed by the above-described third step is released at different positions of the main die roller (60). A fourth step of winding the film 1 continuously into a predetermined shape to make a finished product for transdermal administration and winding up and removing the residual release film 26 generated at this time; And a fifth step of adsorbing the finished product of the transdermal agent by the vacuum pad roller (90) from the main die roller and moving it onto the conveyor (62). The disc roll according to claim 1, wherein in the first step, when the disc roll 10 is composed of the release film 1, the chemical layer 3, the stretchable film layer 4, and the release liner layer 5, the disc roll is continuous. The method of manufacturing a transdermal drug administration, characterized in that it further comprises the step of winding the release liner layer (5) removed from the original roll when unwinding. The drug of claim 1, wherein the shape of the second half die cutting is an ellipse or a circle, and the die cutting shape is a shape that encloses the half die cut drug layer in a concentric manner. Method for the preparation of transdermal administration agents. A first unwinding roller 12 which unwinds the original roll 10 made of the release film 1, the chemical layer 3, the stretchable film layer 4, the release liner layer 5; A winding roller 64 winding the release liner layer 5 peeled off from the original roll; A pair of first half die cutting rollers (14, 14 ') for half die cutting only the release film (1) of the unwound disc roll in a longitudinal direction; Kiss cutting blades of a plurality of predetermined shapes at equal intervals on the circumferential surface for simultaneously half-cutting the drug layer 3 and the stretchable film layer 4 laminated on the release film 1 of the disc roll to a predetermined shape ( A second half die cutting roller 52 on which 52c) is placed; A roller (66) for winding the scrap to remove residual scrap (16) of the drug layer and the stretchable film layer caused by the second half die cutting; The strip laminated with the release film (1) + the predetermined shape half-cut the drug layer (3) and the stretchable film layer (4) is a half-die cut drug layer (3) and the stretchable film layer (4) of the predetermined shape A plurality of die cutting blades are placed at equal intervals on the circumferential surface to die-cut the release film 1 into a predetermined shape so as to surround the inside concentrically. A die cutting roller 59; A winding roller for winding and removing the residual release film 26 generated during the die cutting; The second half of the drug layer and the stretchable film layer formed on the upper surface of the release film being vacuum-sorption-moving, and a plurality of vacuum suction holes are formed on the outer circumferential surface to adsorb and transport the release film of the disc roll. Half-cutting action of die cutting roller 52 and die-cutting action of die-cutting roller 59 to strip of drug film 3 and elastic film layer half-die cut into release film 1 + predetermined shape. A main die roller 60 for performing the step; And a vacuum pad roller (90) having a plurality of rubber adsorption boards on the outer circumferential surface for absorbing the finished product of the transdermal agent from the main die roller and moving onto the conveyor. A first unwinding roller 12 which unwinds the original roll 10 made of the release film 1, the chemical layer 3, and the stretchable film layer 4; A pair of first half die cutting rollers (14, 14 ') for half die cutting only the release film (1) of the unwound disc roll in a longitudinal direction; Kiss cutting blades of a plurality of predetermined shapes at equal intervals on the circumferential surface for simultaneously half-cutting the drug layer 3 and the stretchable film layer 4 laminated on the release film 1 of the disc roll to a predetermined shape ( A second half die cutting roller 52 on which 52c) is placed; A roller (66) for winding the scrap to remove residual scrap (16) of the drug layer and the stretchable film layer caused by the second half die cutting; The strip laminated with the release film (1) + the predetermined shape half-cut the drug layer (3) and the stretchable film layer (4) is a half-die cut drug layer (3) and the stretchable film layer (4) of the predetermined shape A plurality of die cutting blades are placed at equal intervals on the circumferential surface to die-cut the release film 1 into a predetermined shape so as to surround the inside concentrically. A die cutting roller 59; A winding roller 95 for winding up and removing the residual release film 26 generated during the die cutting; The second half of the drug layer and the stretchable film layer formed on the upper surface of the release film being vacuum-sorption-moving, and a plurality of vacuum suction holes are formed on the outer circumferential surface to adsorb and transport the release film of the disc roll. Half-cutting action of die cutting roller 52 and die-cutting action of die-cutting roller 59 to strip of drug film 3 and elastic film layer half-die cut into release film 1 + predetermined shape. A main die roller 60 for performing the step; And a vacuum pad roller (90) having a plurality of rubber adsorption boards on the outer circumferential surface for absorbing the finished product of the transdermal agent from the main die roller and moving onto the conveyor.