KR20120138066A - Natural oriental herb medicine composite for treatment of atopy and acne and the manufacturing method thereof - Google Patents

Abstract

PURPOSE: A natural oriental medicinal crude drug composition and a method for preparing the same are provided to suppress histamine and cytokine and to prevent inflammation and secondary infection. CONSTITUTION: A natural oriental medicinal crude drug for treating atopy and acne contains: a Rehmanniae Radix fermentation extract prepared by fermenting Rehmanniae Radix at 35 Deg.C. for 3 months and extracting; a Rehmanniae Radix fermentation extract prepared by fermenting at 35 Deg.C. for 3 months and extracting; a garlic fermentation extract prepared by fermenting garlic at 35 Deg.C. for 3 months and extracting; and a Chinese matrimony vine fermentation extract prepared by fermenting Chinese matrimony vine at 35 Deg.C. for 3 months and extracting. [Reference numerals] (AA) Age; (BB) Before application; (CC) After application; (DD,EE) One year old female; (FF,GG) 26-Mar-11; (HH,II) 2 weeks later; (JJ,KK) 09-Apr-11

Description

Natural oriental herb medicine composite for treatment of atopy and acne and the manufacturing method

The present invention relates to a natural herbal herbal composition and a method of manufacturing the same, and more particularly, to atopic and acne-improving natural herbal herbal composition and a method for producing the same that can simultaneously treat atopy and acne.

Atopy is a contact antigen, a specific antigen introduced through house dust mites, animal epithelium, pollen, cockroaches, fungi, physical stimuli, microorganisms, mental factors, allergic family history, food intake, effects of living and the environment, missing skin layers, etc. Specific IgE, produced by repeated exposure to, binds to mast cell receptors and induces hypersensitivity type I allergic inflammatory reactions. The mechanism is a disease that causes severe itching, skin dryness, erythema, exudate and recurrent chronic allergic eczema by rapidly increasing histamine release, leukotrienes, prostagladin, etc. due to eosinophil infiltration and degranulation of mast cells. The role of chemical mediators in hypersensitivity type I allergic reactions is as follows.

histamine and leukotrienes are known to cause epithelial injury, leukocytosis and activation, neurostimulation, smooth muscle contraction, and hypervascular permeability.

-prostagladin is a leukocyte suppuration and activation, neurostimulation, smooth muscle contraction, vascular permeability

As a chemical medium, monocytes, macrophages, and T cells are introduced into the dermis of atopic dermatitis. Produces IL-2, IFN-γ, and TNF-β in Th1 lymphocytes of cell-mediated inflammatory response, resulting in cytotoxic, delayed-type hypersensitivity and macrophage activity. Th2 lymphocytes secrete cytokines such as IL-4, IL-5, IL-6, IL-9, IL-10, and IL-13 to stimulate the growth of antibody-producing B cells and stimulate the production of antibodies such as IgE and IgG1 Involved in antigen-antibody reactions. Macrophages secrete cytokines such as IL-1, IL-8, and TNF-α, resulting in repetitive symptoms of severe itching in atopic dermatitis, accompanied by damage to the skin barrier or inflammatory reactions of secondary infections, and increased skin thickness. Tae-tae-hwa appears.

Treatment of atopic dermatitis is a popular method of protecting the skin: popular therapies that reduce pruritus on the skin, treatment for dermatitis and identification and removal of triggers. Treatment can be expected to alleviate the symptoms mainly with the use of antihistamines, topical or systemic steroids, but in some cases untreated treatments can occur. Moreover, continuous use of steroids causes side effects such as skin atrophy.

Basic treatments include analysis and removal of exacerbation factors, topical steroids, and topical calcineurin inhibitors (tacrolimus, pimecrolimus) .Ancillary treatments include antihistamines, skin infection control agents, and phototherapy, while immunosuppressive drugs include systemic steroids and cyclosporine. , Mycophenolate mofetil, and Omalizumab and Efalizumab.

However, topical steroids are thin in the skin, and in the elderly and children, steroids may cause skin atrophy, face and chest steroids, inhibiting pituitary-adrenal contraction, delaying growth, anthropogenic Cushing syndrome, osteoporosis, avascular necrosis, and drug interactions. , Side effects such as decreased immune response, growth disorders, immunosuppressive agents such as elevated blood pressure, increased BUN and uric acid, hypertension, headache, hydration, abnormal sensations, nausea, hyperlipidemia, purulent rash, and biological agents Has been reported to cause side effects such as worsening of skin symptoms, staphylococcal infections, herpes infections.

The social life of atopic dermatitis patients affects not only emotions, companionship, learning and play, but also changes in their appearance in the qualitative part of the patient's life, resulting in self-esteem, disability of life and psychiatric disorders, which greatly affects family relationships. Atopic patients, especially those with severe itching, are unable to sleep well at night, lack of confidence in the body, emotional anxiety and sensitivity compared to normal children, difficult to express dissatisfaction, act as a barrier to childhood growth, and especially in boys More often, puberty is considered suicide, and bacterial and viral fungal infections continue to occur, sometimes requiring hospitalization due to severe eczema and bacterial infections.

Acne, on the other hand, is an inflammatory disease of the skin and hair follicles, but usually occurs in puberty. However, in adults in their 20s and 40s, sebaceous glands develop in the face and chest.

Acne triggers include:

First, the production and secretion of Androgen male hormone before and after puberty increases sebaceous gland proliferation and sebum secretion. Androgen is a generic term for the steroid group of C19, which is produced by testosterone, Androstenedione (AD), dehydroepiandrosterone (DHEA) and the adrenal cortex, androstenedione (AD) and dehydroepiandrosterone (DHEA), which are secreted by the testes, males testicles, females adrenal gland Secreted by the ovary Testosterone is converted to Dihydrotestosterone (DHT) by the catalysis of the 5α-reductase enzyme, and DHT is more potent androgen than Testosterone. Dihydrotestosterone (DHT) and Testosterone hormones are known to stimulate the growth of sebaceous gland cells. It is an oral medication that suppresses it. Anti-androgen therapy is used for women, but it can cause systemic side effects.

Second, the peroxisome proliferator activated receptor of nuclear receptors, which play an important role in adipocyte differentiation, is also expressed in sebaceous gland cells, increasing sebum production.

Third, Corticotrophin releasing hormone is a stress hormone released by the hypothalamus that inhibits the function of the skin barrier and acts to increase the levels of cytokines IL-6 and IL-8 or worsen acne in sebaceous gland cells.

Fourth, Insulin like growth factor I (IGF-Ⅰ), a type of peptide hormone, is known to be a factor in sebum production due to elevated serum levels in adolescent women.

Fifth, Histamine is a substance secreted from mast cells in hypersensitivity reactions and is known to act on sebum production. It can be induced by antihistamines.

These causes promote the increase of sebum secretion and sebum volume, thickening the keratin of the pores wall to prevent the sebum is discharged smoothly to cause acne. Indirect causes include stress, lack of sleep, drinking, food, and cosmetics.When stressed, steroid hormones and androgens are secreted together, alcohol acts to exacerbate inflammation, and oil-rich cosmetics can block pores. It makes acne worse. Acne occurs as a complex circle, and currently, drug treatment such as hyperkeratosis, acne bacterium suppression, and inflammatory reaction suppression is carried out.Any problem of treating and improving acne is inhibiting sebum production, inhibiting acne bacteria and secondary skin infections. , Suppression of hyperkeratosis in the hair follicle wall.

Direct causes of acne include Androgen male hormone production and secretion, other hormones and histamine. Indirect factors include stress, lack of sleep, drinking, food, and the use of inappropriate cosmetics.

As a result, sebum secretion and epidermal epithelial cells increase, the entrance of the hair follicles is closed, the sebum is stagnated in the hair follicles, and inflammation occurs. Sclerosis, papule formation, pustules and nodules are formed.

 In this process, the action of microorganisms is a factor that causes purulent inflammation. In general, acne is caused by Propionibacterium acnes, but the type of microorganism that causes acne inflammation is “C” in university dermatology. Microbial Investigation of Acne Patients Admitted to Dermatology at “C” University Hospital as Presented in the Study of Bacteria Culture and Antibiotic Susceptibility in Acne Patients, Journal of Korean Dermatology 2005; 43 (7): 871-875 The result is shown as follows.

In 38 patients with acne, 3 acne rashes and 41 patients, “C” university hospital dermatology, the proportions and proportions of acne-inflammation microorganisms were 8 in Propionibacterium acnes (19.5%) and 8 in Staphylococcus epidermidis (19.5). %), 5 patients with P. acnes & S. epidermidis infection (12.2%), 2 patients with Staphylococcus aureus (4.9%), 2 patients with P. acnes & S. aureus (4.9%) Two S. capitis infections (4.9%) and two Enterobactor aerogenes (4.9%). Acne inflammatory microorganisms are not only caused by acne bacteria, but Staphylococcus bacteria also cause purulent inflammation of acne. It is shown.

Acne treatments include oral antibiotics and retinoids, application of external medications, blemishes, and chemical peels.In addition, antibiotics such as tetracycline, clindamycin, and erythromycin are used to treat acne, but they cause side effects or long-term antibiotic resistance. The therapeutic effect may decrease.

As a development trend for the treatment of acne, it is mainly used for anti-Bacteria preparations which are useful for skin cleansing effect, inhibiting excessive secretion of male hormone, excessive sebum control effect, propionibacterium acnes and bacteria and fungi. In recent years, interest in natural products known for antibacterial and anti-inflammatory activity has increased, and bee venom, bamboo salt, green tea, eosungcho, pine pollen, rooibos, tea tree oil, plum, wolfberry, aloe, papaya, willow, chitosan and phytosphingosine As a mixed preparation, development of acne treatments, herbal compositions, and the like have been used.

In terms of quality of life, acne sufferers suffer more mental stress in women in their 30s and 40s, more often in women, older, chronic acne symptoms than men.

Therefore, there is a need for a method capable of effectively treating atopy and acne without side effects.

An object of the present invention is a natural herbal herbal composition for improving atopy and acne which can improve atopy and acne at the same time by using six kinds of compositions such as red ginseng, ripening sulfur, garlic, wolfberry, black soybean, and aloe extract as raw materials. In providing.

In addition, an object of the present invention is to develop a cosmetic that can improve atopy and acne at the same time by using six kinds of compositions such as red ginseng, sperm sucrose, garlic, wolfberry, black soybean, aloe extract, and natural lotion type formulations. To provide a natural herbal herbal composition for improving atopy and acne to improve skin absorption and moisturization by using a vegetable oil, water-soluble herbal herbal extract and olive emulsifying wax, which is a natural emulsifier, to enhance skin affinity and moisturization. have.

In addition, an object of the present invention is to develop a cosmetic that can improve atopy and acne at the same time by using six kinds of compositions such as red ginseng, succinct hwang, garlic, wolfberry, black soybean, aloe extract, as a supplement to promote skin cell metabolism The present invention provides a natural herbal herbal composition for improving atopy and acne without adding a vitamin C, riboflavin, and pyridoxine, and using paraben-based chemical preservatives to reduce side effects on sensitive skin.

In order to achieve the above object, natural herbal herbal composition for atopic dermatitis and acne improvement according to the present invention, after the sterilization treatment of Sukji sulfur, fermented extract of Sukji sulfur extracted by fermentation for 3 months at 35 ℃; After sterilizing the ginseng, fermented extract extracted by fermentation for 3 months at 35 ℃; After washing the garlic, the garlic fermented extract extracted by fermentation for 3 months at 35 ℃; After sterilization of the wolfberry, fermented extract extracting fermented for 3 months at 35 ℃; Black beans fermented extract extracted by fermentation at 35 ℃ for 3 months after sterilization; And after sterilizing the washed aloe, pulverized in a sol state to prepare a liquid state, and then filtered uniform aloe extract; including, the ripening sulfur fermentation extract, red ginseng fermentation extract, garlic fermentation extract, wolfberry fermentation The extract, black soybean fermented extract and aloe extract is characterized in that the secondary fermentation for at least 3 months at 20 to 30 ℃.

In order to achieve the above object, the method for producing atopy and acne improved natural herbal herbal composition according to the present invention, after sterilization of Sukji sulfur, red ginseng, garlic, wolfberry and black soybeans, fermented for 3 months at 35 ℃ extraction Preparing a primary herbal fermented extract; Sterilizing the washed aloe, pulverizing it into a sol state to prepare a liquid state, and then preparing an aloe gel extract to produce a filtered uniform liquid aloe extract; And a step of preparing the second herbal fermentation extract for fermenting the fermented extract for two months or more at 30 ° C. by mixing the first fermented sukji sulfur fermentation extract, gooseberry fermentation extract, garlic fermentation extract, goji berry fermentation extract, black soybean fermentation extract and aloe gel extract. It characterized by including;

Natural herbal herbal composition for improving atopy and acne according to the present invention and a method for producing the same have the following effects.

First, it is effective to suppress the chemical mediator (histamine, cytokine) produced by the hypersensitivity reaction type I of atopy using natural substances.

Second, it uses natural substances to inhibit DHT, Testosterone hormone, which proliferates sebum cells of acne.

Third, there is an effect of suppressing the production of lipids involved in the sebum of acne using natural substances.

Fourth, there is an effect of using a natural antimicrobial agent to suppress the inflammatory response and secondary infection of atopy and acne.

Fifth, it is effective to suppress the formation of atopic dermatitis and acne hyperkeratosis using natural substances.

Sixth, using an activated natural substance is effective to regenerate cells damaged by atopy and acne.

Seventh, it is effective to protect the damaged skin barrier of atopy and acne by using moisturizing functional natural substances.

1 to 3 is a view showing the clinical results for atopic patients in accordance with an embodiment of the present invention.
4 and 5 is a view showing the clinical results for acne patients according to an embodiment of the present invention.
Figure 6 is a view showing the antimicrobial test results for natural herbal herbal extracts according to an embodiment of the present invention.

Looking at a preferred embodiment of the present invention together with the accompanying drawings as follows, when it is determined that the detailed description of the known art or configuration related to the present invention may unnecessarily obscure the subject matter of the present invention The detailed description will be omitted, and the following terms are terms defined in consideration of functions in the present invention, which may vary according to the intention or custom of the user or operator, and the definitions thereof are natural herbal medicines for improving atopy and acne. It should be made based on the contents throughout the specification to describe the composition and its preparation method.

First, the differences and commonalities between atopy and acne inflammatory response are as follows. The difference between the two inflammatory reactions is atopic dermatitis induced by hypersensitivity type I, and acne is a dermatitis that develops with excessive sebaceous gland with hormones such as Androgen. In addition, atopic dermatitis is caused by inflammation of the secondary bacterial infection due to damage to the skin barrier due to itching of the skin, acne is formed by pulp formation and papule growth of the sebaceous glands, inflammation occurs.

On the other hand, atopic and acne cause different, but the mechanism of the inflammatory response in the human body is similar, it can be seen in the form of dermatitis. Therefore, in the present invention, by adding a herbal herbal ingredients for other differences between the hypersensitivity response inhibitors of atopy and the hormonal properties of acne, by applying the herbal herbal ingredients that can suppress the inflammatory response in common to act as a major cause of skin problems We propose cosmetics for improving atopy and acne. In order to meet this object, it is preferable that the herbal herbal medicine according to the present invention fulfills five functions.

First, it is a natural substance that inhibits chemical mediators (histamine, cytokine) produced by type I hypersensitivity reactions.

Second, natural substances that inhibit DHT, Testosterone hormone, which proliferate acne sebaceous cells.

Third, natural substances that inhibit the production of lipids involved in the sebum of acne.

Fourth, natural antimicrobial substances that inhibit the inflammatory response and secondary infection of atopy and acne.

Fifth, natural substances by inhibiting the formation of atopic dermatitis and cellular hyperkeratosis of acne.

Sixth, activated natural substances to regenerate cells damaged by atopy and acne.

Seventh, moisturizing functional natural substances that can protect the damaged skin barrier of atopy and acne.

Hereinafter, the components and features of the natural herbal herbal composition for improving atopy and acne according to a preferred embodiment of the present invention will be described.

According to the present invention, the natural herbal herbal composition for improving atopy and acne is made from six kinds of compositions such as red ginseng, succinct hwang, garlic, wolfberry, black soybean, and aloe extract in consideration of the properties described above. Manufactures acne improvement cosmetics. In addition, the formulation of the lotion type (type) uses olive emulsified wax, a natural emulsifier, to promote skin cell metabolism to complete skin absorption and moisturization by increasing the affinity between natural vegetable oils, water-soluble herbal herbal extracts and skin lipid components. Vitamin C, riboflavin, pyridoxine, and other vitamins were added as supplements, and paraben-based chemical preservatives were not used to reduce side effects on sensitive skin.

On the other hand, conventional atopy for improving troubles, acne cosmetics are N-stearoyl- phytosphingosine, ceramide, root extract, moisturizer, seaweed extract, deep sea water, corn polysaccharide, grape seed oil, allantoin, chemical emulsifier, petroleum compound, synthetic polymer, Chemicals such as phytosphingosine, aromatic oils, organic extracts, oatmeal, chemical preservatives (methylparaben, propylparaben, butylparaben) and moisturizers do not have specific effects on atopy and acne. It may be composed of chemicals and cause side effects.In addition, products that use preservatives in some products may cause secondary infection due to microbial contamination, and products that use paraben-based chemical preservatives may cause May cause side effects, which can be very effective in treating atopic dermatitis and acne A situation that can not help, itching of the skin, the skin is minimal protection features such as damaged skin regeneration has not merely not help improve eczema and acne as a product focused on skin hydration.

Therefore, the present invention improves the shortcomings of the existing products as described above, and proposes a natural herbal herbal composition that can alleviate and improve atopic and acne skin diseases, the composition is ripening yellow fermented extract, high samsam fermented extract, garlic fermented extract, Fermented Gojija extract, black soybean fermented extract, aloe extract and the like.

On the other hand, the extract using the chemical process method using an organic solvent extraction method such as ethanol, methanol, propylene glycol, etc. as a conventional method of extraction has a small amount of harmful chemical residues, causing irritation and damage to the skin, changes and reduction of functional substances In this invention, the natural fermentation extraction method is used as a microbial fermentation method that can prevent the loss and change of functional materials.

At this time, the strain used for fermentation uses 'Saccharomyces.spp', and the fermented microorganism extract component is stabilized by fermentation with 5 ~ 10% amount as a nutrient source of the strain and the fermentation microorganism produces low-molecular substances. The conversion to increase the absorbency to trouble skin and increase the effective functionality.

In addition, in the fermentation process, the fermenter is sterilized by spraying 70% alcohol to remove unnecessary microorganisms harmful to fermentation. After the disinfection is completed, the heated extract and the extraction foil of each raw material are added together to introduce a complete fermentation extraction process at a temperature of 25 ~ 37 ℃ at room temperature to extract the maximum complete components in a small amount of raw materials.

Meanwhile, the fermentation process uses a secondary fermentation method for at least three months to achieve homogenization of the herbal components by mixing the fermented herbal medicines in a large fermenter after three months of primary fermentation for each raw material.

At this time, a high-pressure sterilization method is used for 15 minutes at 121 ℃ 15 pound pressure as a method for removing the alcohol component produced in the fermentation process and killing the large-grown Saccharomyces.spp. In addition, by removing the fine particles of the killed Saccharomyces.spp and fermented extract using a negative pressure 'micro pore membrane filter' method.

In addition, the olive emulsifying wax added to the formulation is used as a natural emulsifier for homogenizing the fat-soluble component and the water-soluble component of the fermented extract, and also emulsifies the lipid component of the fat-soluble skin to increase the skin penetration of the active ingredient. In addition, vitamin C, riboflavin, pyridoxine, and other vitamins are added as a promoter of cell activity and metabolism of skin epithelial cells, and natural vegetable oils that are easily absorbed as skin moisturizers and skin protection agents are used.

Hereinafter, each component and each manufacturing step of the atopy and acne treatment agent according to the present invention described above will be described in more detail.

First herbal fermented extract preparation

1. Manufacture of Sookjihwang Fermented Extract

Sukjiwang contains catapol, rehmannin, aucubin, rehmannioside (A, B, C, D), leonuride, monomeltittoside, dihydrocatalpol, amino acid, and other trace elements.

In agreement, Sooji Hwang is said to be warm and have a sweet and bitter taste. Sukjiwang replenishes the blood and blackens the hair, fills the bone marrow and makes the muscles healthy. He also said that it strengthens bones, replenishes weaknesses, makes blood flow through, improves energy, and keeps ears and eyes healthy. The growth-promoting effect of Sukjiwang used for the treatment of cardiovascular and neurological diseases through the treatment of damaged spinal cord axon was verified.

In addition, succinate sulfur has a physiological activity such as reduction of lipid components such as total cholesterol and triglyceride, antioxidant activity such as increased glutathione peroxidase activity, decreased serum peroxide content, and increased super oxide dismutase activity in relation to anti-aging.

-Sukjihwang 1st fermentation extract manufacturing process

① Washing: Wash 75 ~ 150g of Sukji sulfur with water to remove impurities.

② Sterilization process: After heating and extracting sterilized sulfuric acid in 100 ℃ water for 10 minutes, it is cooled to room temperature.

③ Fermentation process: The fermenter is sprayed with 70% alcohol and disinfected. 1 kg of water, sterilized sujihwang and extract are added together, fermented with 5-10% of the fermenter, and then inoculated with Saccharomyces.spp strain.

④ 1st fermentation temperature and period: Extract fermentation 3 months at 35 ℃.

2. Preparation of the First Fermented Extract of Ginseng

Ginseng is an alkaloid compound that contains matrine, matrin N-oxide, allomatrine, isomatrine, sophoranol, sophoranol N-oxide, sophoramine, N-methylcytisine, anagyrine, batifoline, and phytoestrogen. Consists of such isoflvones compounds and inhibits the activity of Androgen.

In addition, ginseng relieves histamine activity in allergic hypersensitivity reactions, inhibits cytokine activity such as IL-8, TNF-α and IL-6, and inhibits activity such as β-hexosaminidase to alleviate dermatitis such as eczema and skin itching. . In addition, the anti-inflammatory effect of 5-lipoxygenase and inducible nitric oxide synthase (iNOS), flavonoid saponin compounds, is anti-inflammatory.

-Ginseng Fermented Extract Manufacturing Process

① Washing: Wash ginseng 75 ~ 200g with water to remove impurities.

② Sterilization process: The washed ginseng is extracted and sterilized by heating for 10 minutes in 100 ℃ water and cooled to room temperature.

③ Fermentation process: The fermenter is sprayed with 70% alcohol and disinfected. 1 kg of water and sterilized gourdaceae extract are added to the fermenter together. After fermentation with 5 ~ 10%, inoculate Saccharomyces.spp strain.

④ 1st fermentation temperature and period: Extract fermentation 3 months at 35 ℃.

3. Garlic primary fermentation extract manufacturing

Garlic contains alliin, allicin, ajoene, scordinin, fructooligosaccharide, allithiamine and essential oils such as citral, geraniol, linanol, and α-β-phellandrene, as well as diallyl sulfide and diallyl which are different sulfur atoms. disulfide, diallyl trisulfide, diallyl tetrasulfide and garlic vitamin B1 (altyamine).

The antibacterial activity of garlic is that allicin and ajoene inhibit antimicrobial activity by inhibiting and delaying lipid synthesis and DNA synthesis in fungi such as Candida albicans, Aspergillus fumigatus, Histoplasma capsulatum and Aspergillus niger. Also, organic sulfur compounds such as diallyl sulfide, diallyl disulfide, Diallyl trisulfide, diallyl tetrasulfide, etc. have more antimicrobial activity against methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia and more.

In addition, garlic is effective in protecting blood vessel endothelial cells, antioxidant activity, and anticancer activity by reducing triglyceride, cholesterol lowering effect, thrombolytic action, and capillary blood circulation improvement, and lipid peroxidation effect. It acts to reduce. In addition, by expanding the peripheral blood vessels of the skin has a physiological activity that facilitates blood circulation.

-Garlic Fermented Extract Manufacturing Process

① Washing: Wash 100 ~ 200g of garlic in water to remove impurities and grind to 1-2mm size.

② Fermentation process: The fermenter is sprayed with 70% alcohol and disinfected. 1 kg of water and washed garlic are added to the fermenter, and 5 ~ 10% is added to the fermenter to inoculate Saccharomyces.spp strain.

③ 1st fermentation temperature and period: Extract fermentation 3 months at 35 ℃.

4. Preparation of Gojija Primary Fermentation Extract

Wolfberry contains betaine, rutin, diosgenin, physalien, zeaxanthin, uracil, β-sitosterol, palmitic acid, linolenic acid, cornin, morrnoniside, loganin, tanin, saponin, ascorbic acid, mineral, amino acid.

Goji has the effect of inhibiting DHT content and activity, which acts as a powerful Androgen hormone, and has anti-aging and detoxification effects by enhancing cellular immunity. In addition, there is a cell regeneration function, collagen synthesis, capillary strengthening action, there is a physiological activity such as cholesterol reduction, antioxidant activity in the blood.

In oriental medicine, it is used as a tonic and antipyretic. Improves eyesight, prevents adult diseases such as diabetes, improves lung and kidney function, hematopoietic, cholesterol lowering, anti-fatty liver, lowering blood pressure, lowering blood sugar, promoting growth, and anticancer. , Beaxanthin, carotene, thiamine, vitamin A, B1, B2, C and the like. The effects of goji berries goji are used for backache as chronic hepatitis, cirrhosis, tonic, antipyretic. Gugijaroot skin is called Jigolpi (地骨皮) is used as an antipyretic such as beef, chills, etc. in Chinese medicine. In the Xinong main menarche, written about 1800 years ago in the Hanhan period, it contains a Chinese medicine, a poisonous ginseng, and a goji berry. 『Bonchogyeong』 has been introduced that it takes a long time to harden the musculature, lighten the body, so that it does not grow old and does not burn hot and cold. In civilian use, we use it as a goji or goji

-Gojija Fermented Extract Manufacturing Process

① Washing: Wash 100 ~ 150g of wolfberry in water to remove impurities.

② Sterilization Process: After washing and sterilizing the heated wolfberry in 100 ℃ water for 10 minutes, cool it to room temperature.

③ Fermentation process: The fermenter is sprayed with 70% alcohol and disinfected. 1 kg of water, sterilized goji and extract are added together, and fermented with 5-10% of the fermenter. Inoculate Saccharomyces.spp strain.

④ 1st fermentation temperature and period: Extract fermentation 3 months at 35 ℃.

5. Preparation of Black Bean Primary Fermentation Extract

Black soybean contains ingredients such as isoflavine, stachyrose, raffinose, sucrose, saponin, phytic acid, essential amino acid, unsaturated fatty acid linoleic acid, oleic acid, palmitic acid, vitamin E and protein. Therefore, the plant estrogen effect, cholesterol lowering, chronic disease prevention, immune function enhancement function, there is a physiological activity such as lowering lipid oxidation reaction, antioxidant effect, promoting blood circulation. On the other hand, the herb is recorded on the efficacy of black soybeans, "controls the kidneys, eliminates edema, activates blood circulation and releases the poison of all drugs."

-Black bean fermented extract manufacturing process

① Washing and crushing: Wash 60 ~ 100g of black soybeans in water to remove impurities, dry moisture, and crush into 1 ~ 2mm size.

② sterilization process: The black soybeans are extracted and sterilized by heating for 10 minutes in 100 ℃ water and cooled to room temperature.

③ Fermentation process: The fermenter is sprayed with 70% alcohol and disinfected. 1 kg of water and sterilized black soybeans and extracts are added together, and fermented with 5-10% of the fermenter, and then inoculated with Saccharomyces.spp strain. .

④ 1st fermentation temperature and period: Extract fermentation 3 months at 35 ℃.

6. Aloe Gel Extract Preparation

Aloe is a perennial herbaceous tropical plant of the genus Lily and Aloe, and has recently been demonstrated pharmacological and physiologically active effects such as anthraquinone derivatives such as aloetin, alprogen, acemannan, aloeurcin, and alomitin. It is good at promoting healing, preventing burns, preventing rheumatism, anti-inflammatory, anti-cancer, antihistamine, immunomodulatory, and other treatments. It also has excellent wound healing effect by enzymatically degrading bradykinin.

In addition, as an bacteriostatic action, anthraquinone derivatives such as aloetin have an inhibitory effect on Pseudomonas aeruginosa, ringworm, Mycobacterium tuberculosis, etc. In addition, alprogen has an inhibitory effect on allergic reactions, acemannan has an effect on strengthening the immune system, aloeurcin has an effect on healing ulcers, and allomitin has an anticancer effect, mannose, glucose, various amino acids, Lipids, minerals, etc. act as a moisturizer.

-Aloe Extract Manufacturing Process

① Washing and peeling: After washing aloe leaves with water, peel and soak only gel component in water for 1 hour.

② Sterilization process: The cleaned aloe gel is heated and sterilized in 100 ℃ water for 10 minutes, and then pulverized the gel in a sol state with a grinder to prepare a liquid state.

③ 5 to remove the fiber by filtration with a micro filter (filter) to prepare aloe extract of a uniform liquid.

④ The liquid aloe extract is heated to add 1kg to the preparation of the second herbal fermented extract.

In the above, the method for preparing primary herbal fermentation extracts for herbal ingredients such as sukji sulfur, red ginseng, garlic, wolfberry, black soybean, and aloe gel was described. Next, the secondary fermentation manufacturing method for the first fermented herbal extract.

Secondary Herbal Fermentation Extract Preparation

In order to achieve the component homogenization of the first fermented herbal extract as described above, the secondary fermentation process is further processed.

1. Second fermentation process

① Fermenter is sprayed with 70% alcohol and sterilized, and 6 kinds of primary fermentation products such as Sukjihwang fermentation extract, red ginseng fermentation extract, garlic fermentation extract, wolfberry fermentation extract, black soybean fermentation extract, and aloe extract are put into a large fermenter. Mix.

② Second fermentation temperature and period: Extract fermentation for 3 months or longer at 20 ~ 30 ℃.

2. Sterilization and Alcohol Removal Process

① Sterilization process and alcohol component removal process: After separating the supernatant of the fermentation extract, the solution is autoclaved at 121 ℃ 15 pounds pressure for 15 minutes to kill Saccharomyces.spp, produced during the fermentation process and present in the fermentation broth Eliminate alcohol and volatile organic components.

3. Purification Process

In order to increase the efficiency of the 'micro pore membrane filter', the filter is first separated by a 5μ filter and a second filtration process is introduced as a final purification process.

① First purification process: Sterilized fermented extract is left in the 4 ℃ freezer for more than 3 days to precipitate solids in the form of particles. In order to separate the clear supernatant from the solid, the supernatant is transferred to another vessel using a siphon phenomenon, and the residue is combined with the vessel by removing the solid particles using a 5 μ filter and filtering the extra herbal extract.

② Secondary purification process: Purify fermented extract by removing dead Saccharomyces.spp and fine impurities using 'micro pore membrane filter'.

In the above, the method for preparing atopic and acne treatments using six herbal ingredients according to the present invention has been described. The content for the lotion-type therapeutic formulation using the prepared composition is shown in Table 1 below, and the content of these components can be changed according to the needs of the manufacturer.

Composition constituting atopy, acne improvement lotion Content (% by weight) Purified water 45 Five kinds of herbal extracts 30 vegetable oil 20 Tocopherol One Natural emulsifiers 4 vitamin a very small amount Neutralization reaction product a very small amount system 100

clinical Example

<Measurement of improvement effect on atopic patients>

SCORAD investigation before and after the use of herbal herbal lotion formulations in atopic patients.The lotion preparation made with natural herbal herbal extracts was applied to 10 patients with atopic dermatitis 2 ~ 3 times a day in the morning for 4 weeks before sleeping. Atopic improvement effect experiment was conducted. Experimental results are shown in Figures 1 to 3.

On the other hand, the survey of each evaluation index is a question that is used in SCORAD INDEX as shown in <Table 2> and <Table 3>, and the degree of feeling felt before and after using the herbal herbal lotion formulation, The experimental results are shown in the following <Table 4> and FIGS.

Symptom Degree of lesion Intensity criteria ). Total points: 18 points 0 (none) 1 (mild) 2 (middle) 3 (severe) Erythema / darkening Edema / Paperosis Tick / Skin abrasion Taesun dry

Symptom Subjective sign. Total score: 20 points Evaluate based on status in last 3 days Pruritus
(Itching) No itching at all 0 Scratching during unconsciousness (does not interfere with life) 1-3 Pleasant enough to disturb your life (not all day long) 4 to 6 Pruritus that interferes with life most of the time 7-9 Severe itching due to itching 10 Sleep disorder No sleep disorders at all 0 A slight feeling of literacy that does not disturb sleep 1-3 I sometimes sleep because of my pruritus 4 to 6 2 or more times per night 7-9 Rarely sleep due to itching 10

Table 2 shows the extent of lesion as SCORAD INDEX, Table 3 shows subjective symptoms.

The test results of ten subjects based on the evaluation criteria are shown in Table 4 below.

Subject age Side Effect Pruritus Sleep
obstacle Erythema edema Water abrasion Taesun dry end part I'm after I'm after I'm after I'm after I'm after I'm after I'm after I'm after One One X O 3 0 5 0 2 0 One 0 0 0 One 0 0 0 0 0 2 3 X O 3 0 5 0 2 0 One 0 0 0 One 0 0 0 0 0 3 12 X O 5 0 6 One 2 0 2 0 0 0 2 0 One 0 One 0 4 16 X O 3 0 3 0 One 0 2 0 0 0 2 0 0 0 One 0 5 17 X O 6 One 5 0 2 One 3 0 One 0 2 0 One 0 One 0 6 22 X O 3 0 3 0 2 0 2 0 0 0 One 0 0 0 0 0 7 27 X O 10 One 10 One 3 0 3 0 3 0 3 0 3 One 3 0 8 36 X O 5 0 5 0 2 One 2 0 0 0 2 0 0 0 0 0 9 45 X O 6 One 6 0 3 0 3 0 One 0 3 One One 0 One 0 10 58 X O 4 0 3 0 2 0 One 0 0 0 One 0 0 0 0 0 commandment) 0 10 3 10 2 10 2 10 0 3 0 10 One 4 One 6 0

In Table 4, the results of subjects 1 and 3 reflect the opinions of parents.

The results of the application for 4 weeks show very positive effects in <Table 4>. The pruritic effect of the unconscious unscrupulously improves so that only 10 to 3 people remain mildly, and the sleep disorder does not interfere with sleep, so only 10 to 2 people remain mildly improving. Erythema has an improvement effect of only 2 out of 10 people, mild edema is effective in 0 out of 10 people, effusion is effective in 0 out of 3 people, and scratches are mild in 1 out of 10 people. It was found to have an improvement effect, and Taesunhwa showed an improvement effect so that only one person out of four remained mild, and the drying effect was improved to zero out of six people. In addition, by using only natural extracts, such as herbal medicines and natural preservatives, no side effects were observed in all 10 people, and also restores skin damage due to inflammation and exfoliation effect.

<Measurement of Acne Improvement on Acne Patients>

1. Antimicrobial Test on Natural Herbal Extracts

The pathogens of acne were 8 cases of propionibacterium acnes (19.5%), Staphylococcus epidermidis, as suggested in the study of bacterial culture and antibiotic sensitivity in acne patients, Korean Journal of Dermatology 2005; 43 (7): 871-875. 8 patients (19.5%), 5 P. acnes & S. epidermidis infections (12.2%), 2 Staphylococcus aureus (4.9%), 2 P. acnes & S. aureus infections (4.9%) ) Two patients (4.9%) were infected with P. acnes & S. capitis and two patients (4.9%) with Enterobactor aerogenes, and antibiotics are a problem that occurs when long-term antibiotic therapy is used to treat acne patients. It is called tolerance.

The status of antibiotic-resistant bacteria published in this study reported that Staphylococcus epidermidis had antibiotic resistance rates of Erythromycin (35.7%), clindamycin (21.4%), and tetracycline (50.0%) as antibiotic-resistant bacteria. According to the report, Propionibacterium acnes is highly susceptible to antibiotics, while Staphylococcus epidermidis has high antibiotic resistance, suggesting that antibiotic therapy is necessary for acne treatment.

In the antimicrobial test of the herbal herbal extracts according to the present invention, except for Propionibacterium acnes, which has little antibiotic resistance in acne causing bacteria, antimicrobial experiments were performed for acne causing bacteria that may exhibit antibiotic resistance.

Strain used in the experiment was used for the experiments to obtain the strain isolated from the 'H' Dermatological acne of hospital patients, the strain is a strain, such as the Gram-positive bacteria Staphylococcus epidermidis, Staphylococcus aureus, and Gram negative rods of Enterobactor aerogenes 10 ⁸ Inoculated in Muller Hinton plate medium at a concentration of cfu / mL.

The antimicrobial test was performed by injecting antibiotics Vancomycin disk and Oxacillin disk to confirm that they were 8mm disk and antibiotic resistant strains in Muller Hinton plate medium inoculated with 10 ⁸ cfu / mL of each bacterium. After incubation in the incubator for 18 hours, an antimicrobial test was performed, and the test results were shown in FIG. 6.

Antimicrobial test results against natural herbal extracts showed that Oxacillin antibiotics were resistant to Enterobactor aerogenes of Gram-positive cocci, Gram-positive bacteria known as antibiotic-resistant bacteria, and Enterobactor aerogenes of Gram-negative bacilli, while Vancomycin antibiotics were sensitive. More natural herbal herbal extracts have shown strong antimicrobial activity.

2. Experiment of herbal herbal lotion formulation for acne patients

1) Lotion formulations prepared with herbal extract lotion formulations of natural extracts should be applied to 10 facial acne patients with skin types of 5 psoriasis and 5 oily eyes 2 ~ 3 times a day in the morning for 4 weeks before going to bed. The acne improvement effect experiment was performed, and the experimental results are shown in the following <Table 5> and FIGS. 4 and 5.

Subject age Acne types Turnover
(%) One 20 papule
(Acne germs multiply, an inflammatory reaction progresses, erythema forms, pain begins, and red sores are called papules) 80 2 22 60 3 24 70 4 17 pustule
(Inflammation progresses and the formation of white blood cells is called purulent acne. 70 5 19 60 6 21 70 7 22 60 8 24 80 9 25 70 10 27 nodule
(When purulent acne progresses and the pustules expand into the surrounding tissues and deep tissues in the skin, causing more inflammation, a rash develops, called a nodule.) 80

Table 5 shows the improvement effect before and after the use of herbal herbal lotion formulation for each acne type. Referring to the result of applying the herbal extract lotion formulation of natural extract for 4 weeks with reference to <Table 5>, three papules have an effect of 60-80% improvement, six pustules of 60-80% There was an improvement effect, and one nodule state showed an improvement effect of 80%. There was an overall improvement effect regardless of the skin type, and there was also an effect of restoring skin damage caused by inflammation and exfoliation effect.

As described above, various substitutions, modifications, and changes can be made by those skilled in the art without departing from the technical spirit of the present invention, and thus, the embodiments and the accompanying drawings are limited. It doesn't happen.

Claims (9)

In the natural herbal herbal composition for atopic and acne improvement,
Sukji sulfur fermented extract extracted by fermentation for three months after the sterilization of succinct;
After sterilizing the ginseng, fermented extract extracted by fermentation for 3 months at 35 ℃;
After washing the garlic, the garlic fermented extract extracted by fermentation for 3 months at 35 ℃;
After sterilization of the wolfberry, fermented extract extracting fermented for 3 months at 35 ℃;
Black beans fermented extract extracted by fermentation at 35 ℃ for 3 months after sterilization; And
After sterilizing the washed aloe, pulverized in a sol state to prepare a liquid state, and then filtered and filtered aloe aloe liquid; includes,
Natural herbal medicine for improving atopic dermatitis and acne, characterized in that the fermented extract of Sukji Hwang extract, Gosam fermentation extract, garlic fermentation extract, goji berry fermentation extract, black soybean fermentation extract and aloe extract and fermented at 20 to 30 ℃ for 2 months or more Herbal composition.
The method of claim 1, wherein the aloe extract,
5 Herbal herbal medicine composition for improving atopy and acne, characterized in that to remove the fiber by filtration with a micro filter.
The method of claim 1, wherein the fermentation extract of each fermentation method,
A raw herbal composition for improving atopy and acne, characterized in that the fermentation tank with each sterilized raw material is added to the fermenter and added with 5 to 10% by weight, followed by inoculation with Saccharomyces.spp strain.
2. The composition of claim 1,
Herbal herbal composition for improving atopy and acne, characterized in that it further comprises any one or more selected from vegetable oils, tocopherols, natural emulsifiers and vitamins.
In the method of manufacturing a natural herbal herbal composition for atopic and acne improvement,
After the sterilization treatment of Sookjihwang, gosam, garlic, wolfberry and black soybeans, the first herbal fermented extract manufacturing step of extracting by fermentation for 3 months at 35 ℃;
Sterilizing the washed aloe, pulverizing it into a sol state to prepare a liquid state, and then preparing an aloe gel extract to produce a filtered uniform liquid aloe extract; And
A step of preparing a second herbal fermentation extract for fermenting the first fermented extract of Sookji sulfur, fermented ginseng fermented extract, garlic fermented extract, goji berry fermented extract, black soybean fermented extract and aloe gel extract and fermented at 30 ° C. for at least 3 months; Method for producing a herbal herbal composition for improving atopy and acne, characterized in that it comprises a.
The method of claim 5, wherein the aloe extract,
Removing the fiber by filtration with a micro-filter 5; Method of producing a natural herbal herbal composition for improving atopy and acne, characterized in that it further comprises.
According to claim 5, The primary herbal fermentation extract manufacturing step,
Washing each raw material to remove impurities;
Sterilizing the washed raw materials and then cooling them at room temperature; And
The sterilized raw materials are added to the fermenter together with water, and added to 5 to 10% by weight, inoculated and fermented with Saccharomyces.spp strains. Natural herbal herbal medicine for improving atopy and acne, comprising: Method of Preparation of the Composition.
According to claim 5, The secondary herbal fermentation extract manufacturing step,
Adding each of the primary fermentation extracts to a fermenter and mixing them;
Removing the microorganism from the fermented extract of the second fermentation and removing the alcohol component; And
Purifying the fermented extract by filtration with a filter; Method of producing a natural herbal herbal composition for improving atopy and acne, characterized in that it further comprises.
The method of claim 8, wherein the purification step,
Leaving the sterilized fermentation extract in a 4 ° C. refrigerator for at least 3 days to precipitate solids in the form of particles by the action of gravity;
Transferring the supernatant to another vessel by using a siphon phenomenon to separate the clear supernatant from the solid, and removing the solid particles using a 5 μ filter on the residue and filtering the excess herbal extract to combine the separation solution into the vessel; And
Purifying the fermentation extract by removing the dead microorganisms and fine impurities using a micro pore membrane filter; Method of producing a herbal herbal composition for improving atopy and acne, characterized in that it comprises a.

Images